Uehara Hisanori 上原久典

… Alternative Names

UEHARA Hisanori 上原久典

上原久典ウエハラヒサノリ

Less

Researcher Number	30263809
Other IDs
External Links
Affiliation (Current)	2025: 徳島大学, 病院, 教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 徳島大学, 病院, 教授 2015: 徳島大学, 大学院医歯薬学研究部, 准教授 2007: The University of Tokushima, Institute of Health Biosciences, Graduate School, associate professor 2006: 徳島大学, 大学院ヘルスバイオサイエンス研究科, 助教授 2001: 徳島大学, 医学部, 助教授 2000: 徳島大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Experimental pathology / Experimental pathology Except Principal Investigator Basic Section 56030:Urology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Tumor therapeutics
Keywords	Principal Investigator 骨転移 / prostate cancer / 前立腺癌 / LSR / FABP4 / 肥満 / bone metastasis / bone marrow-derived stromal cells / 骨髄間質細胞 / 前立線癌 / 転移関連遺伝子 / 前立腺 … More Except Principal Investigator … More 尿路上皮癌 / 個別化医療 / 鶏卵 / PDX / mutant p53 / EGFR / TP53変異 / p53変異 / DDX31 / 膀胱癌 / 腎癌 / 免疫チェックポイント阻害薬 / AIH / ICSI / TESE / sperm analysis / 精子 / 精子無力症 / 男性不妊症 / LED / 薬剤スクリーニング / 薬剤耐性 / 泌尿器癌 / CAM / 腎細胞癌 / シグナルクロストーク / GGCT / グルタミン酸代謝 / メタボローム / がん / PGE2受容体 Less

RCC Precision Medicine Project using PDX models
- Principal Investigator
  
  高橋正幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  The University of Tokushima
Mutant p53 - Cancer Immunology Research from the DDX31 axis
- Principal Investigator
  
  大豆本圭
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  The University of Tokushima
Development of Next Generation "Light" Fertility Treatment Using LEDs
- Principal Investigator
  
  KUSUHARA Yoshito
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokushima
Development of a next-generation patient-derived cancer model using chicken eggs and establishment of a drug screening method
- Principal Investigator
  
  KANAYAMA Hiroomi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokushima
A novel signaling crosstalk between prostaglandin E2 receptors and IGF-1 receptor as a possible molecular target for antitumor therapy
- Principal Investigator
  
  TAKAHASHI Tetsuyuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Musashino University
Role of fatty acid binding protein 4 (FABP4) as an exogenous ligand, on growth of prostate cancer cellsPrincipal Investigator
- Principal Investigator
  
  UEHARA Hisanori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokushima
Trial of inhibition of prostate cancer cell growth in the bone using bone marrow-derived stem cellsPrincipal Investigator
- Principal Investigator
  
  UEHARA Hisanori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokushima
ヌードマウス前立腺内および骨内におけるヒト前立腺癌細胞の転移関連遺伝子発現の比較Principal Investigator
- Principal Investigator
  
  上原久典
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokushima

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2007

All Journal Article Presentation

[Journal Article] 当院における患者由来PDXモデルを用いた取り組み-個別化医療を目指して-2023
- Author(s)
  大豆本圭、高橋正幸、宇都義浩、上原久典
- Journal Title
  
  泌尿器科外科
  
  Volume: 36 Pages: 906-908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08736
[Journal Article] Insulin receptor expression to predict resistance to axitinib and elucidation of the underlying molecular mechanism in metastatic renal cell carcinoma2023
- Author(s)
  Takahashi Masayuki、Daizumoto Kei、Fukawa Tomoya、Fukuhara Yayoi、Bando Yoshimi、Kowada Minoru、Dondoo Tsogt-Ochir、Sasaki Yutaro、Tomida Ryotaro、Ueno Yoshiteru、Tsuda Megumi、Kusuhara Yoshito、Yamaguchi Kunihisa、Yamamoto Yasuyo、Uehara Hisanori、Kanayama Hiroomi
- Journal Title
  
  British Journal of Cancer
  
  Volume: 129 Issue: 3 Pages: 521-530
- DOI
  10.1038/s41416-023-02325-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06613, KAKENHI-PROJECT-23K08736, KAKENHI-PROJECT-23K08758
[Journal Article] 当院における患者由来PDXモデルを用いた取り組み-個別化医療を目指して-2023
- Author(s)
  大豆本圭、高橋正幸、宇都義浩、上原久典
- Journal Title
  
  泌尿器科外科
  
  Volume: 36 Pages: 906-908
- Open Access
- Data Source
  KAKENHI-PROJECT-23K08758
[Journal Article] 鶏卵を用いた次世代患者由来がんモデルの開発2020
- Author(s)
  大豆本圭、金山博臣、上原久典、宇都義浩
- Journal Title
  
  Medical　Science Digest
  
  Volume: 46 Pages: 59-61
- Data Source
  KAKENHI-PROJECT-19K22689
[Journal Article] Adipose tissue:Critical contributor to the development of prostate cancer2018
- Author(s)
  Hisanori Uehara, Tomoko Kobayashi, Minoru Matsumoto, Shunsuke Watanabe, Akiko Yoneda, and Yoshimi Bando
- Journal Title
  
  J. Med. Invest.
  
  Volume: 65 Issue: 1.2 Pages: 9-17
- DOI
  10.2152/jmi.65.9
- NAID
  130006575624
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08403
[Journal Article] Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.2017
- Author(s)
  Watanabe S, Takahashi T, Ogawa H, Uehara H, Tsunematsu T, Baba H, Morimoto Y, Tsuneyama K.
- Journal Title
  
  Metab Syndr Relat Disord.
  
  Volume: 15(4) Issue: 4 Pages: 170-177
- DOI
  10.1089/met.2016.0114
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15098, KAKENHI-PROJECT-15K15740, KAKENHI-PROJECT-15K06873
[Journal Article] Histopathological characteristics of glutamine synthetase-positive hepatic tumor lesion in a mouse model of spontaneous metabolic syndrome (TSOD mouse).2016
- Author(s)
  Tetsuyuki Takahashi, Takeshi Nishida, Hayato Baba, Hideki Hatta, Johji Imura, Mitsuko Sutoh, Syunji Toyohara, Ryoji Hokao, Syunsuke Watanabe, Hirohisa Ogawa, Hisanori Uehara, Koichi Tsuneyama.
- Journal Title
  
  Mol. Clin. Oncol.
  
  Volume: 5 Pages: 267-270
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06873
[Presentation] 鶏卵モデルを用いた免疫チェックポイント阻害剤の新規スクリーニングモデルの可能性2023
- Author(s)
  大豆本圭、宇都義浩、上原久典、西山美月、冨田諒太郎、布川朋也、高橋正幸
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08758
[Presentation] 鶏卵モデルを用いた免疫チェックポイント阻害剤の新規スクリーニングモデルの可能性2023
- Author(s)
  大豆本圭、宇都義浩、上原久典、西山美月、冨田諒太郎、布川朋也、高橋正幸
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08736
[Presentation] 射精障害に対してOnce　TESEを施行した進行性精巣腫瘍の1例2022
- Author(s)
  大豆本圭、堀克仁、角陸文哉、佐々木雄太郎、上野恵輝、冨田諒太郎、津田恵、楠原義人、布川朋也、山口邦久、山本恭代、高橋正幸、金山博臣、上原久典、新家崇義、岩佐武
- Organizer
  第110回日本泌尿器科学会四国地方会
- Data Source
  KAKENHI-PROJECT-21K19573
[Presentation] 診断に苦慮した間欠性精巣捻転の１例2022
- Author(s)
  大豆本圭、高橋正幸、堀克仁、角陸文哉、佐々木雄太郎、上野恵輝、冨田諒太郎、津田恵、楠原義人、布川朋也、山口邦久、山本恭代、金山博臣、上原久典、新家崇義
- Organizer
  第110回日本泌尿器科学会四国地方会
- Data Source
  KAKENHI-PROJECT-21K19573
[Presentation] ロボット支援前立腺全摘除術・リンパ節郭清におけるLNIの検討2021
- Author(s)
  安宅真利花、大豆本圭、尾﨑啓介、佐々木雄太郎、上野恵輝、津田恵、楠原義人、布川朋也、山本恭代、山口邦久、高橋正幸、金山博臣、上原久典
- Organizer
  西日本泌尿器科学会
- Data Source
  KAKENHI-PROJECT-21K19573
[Presentation] Micropapillary urothelial carcinomaの病態解明と新規治療法の探索2021
- Author(s)
  大豆本圭、福原弥生、上原久典、佐々木雄太郎、尾﨑啓介、上野恵輝、津田恵、楠原義人、布川朋也、山本恭代、山口邦久、高橋正幸、金山博臣
- Organizer
  泌尿器科分子細胞研究会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] 尿路上皮癌に対するDDX31/NCL相互作用阻害による抗腫瘍効果の検討2020
- Author(s)
  大豆本圭、福原弥生、布川朋也、片桐豊雅、上原久典、高橋正幸、金山博臣
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] 病勢コントロールが困難であった前立腺原発yolk sac tumor の1例2020
- Author(s)
  大豆本圭、矢野哲弘、佐々木雄太郎、尾﨑啓介、上野恵輝、津田恵、楠原義人、森英恭、布川朋也、山本恭代、山口邦久、高橋正幸、金山博臣住田智志、上原久典、宇山直人
- Organizer
  西日本泌尿器科学会四国地方会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] 発育鶏卵を用いた患者由来がんモデルの開発2020
- Author(s)
  宇都義浩、大豆本圭、福原弥生、上原久典、金山博臣
- Organizer
  日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] 発育鶏卵を用いた患者由来の腫瘍組織移植法の検討2020
- Author(s)
  小西大輔、二若真菜、藤原由莉、折村奈美、金山博臣、上原久典、大豆本圭、宇都義浩
- Organizer
  泌尿器科分子細胞研究会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] 筋層浸潤性膀胱癌の多段階進展機構の病態解明と治療標的分子の固定2020
- Author(s)
  大豆本圭、津田恵、楠原義人、森英恭、布川朋也、山本恭代、山口邦久、中逵弘能、福森知治、高橋正幸、上原久典、片桐豊雅、金山博臣
- Organizer
  日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] 当院における転移・再発をきたした乳頭状腎細胞癌の検討2020
- Author(s)
  矢野哲弘、大豆本圭、上原久典、宇山直人、佐々木雄太郎、尾﨑啓介、上野恵輝、津田恵、楠原義人、布川朋也、山本恭代、山口邦久、高橋正幸、金山博臣
- Organizer
  西日本泌尿器科学会四国地方会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] マウス皮下移植にて形態維持可能な淡明細胞型腎細胞癌細胞株の樹立2020
- Author(s)
  福原弥生、大豆本圭、布川朋也、上原久典、小和田実、福森知治、高橋正幸、金山博臣
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] 当科における患者腫瘍組織移植PDX（patient-derived xenograft)モデル作製の取り組みとMicropapillary urothelial carcinomaのPDX　modelの樹立2019
- Author(s)
  大豆本圭、福原弥生、尾﨑啓介、津田恵、楠原義人、森英恭、布川朋也、山本恭代、山口邦久、福森知治、高橋正幸、金山博臣、上原久典
- Organizer
  日本泌尿器科学学会総会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] 淡明細胞型腎細胞癌のPDC（Patient-Derived Cell)の樹立2019
- Author(s)
  福原弥生、大豆本圭、布川朋也、上原久典、小和田実、福森知治、高橋正幸、金山博臣
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] ESR1発現欠損による乳がん悪性化の分子機序の解析2018
- Author(s)
  青木寧々、青木夏美、木田ほのか、上原久典、高橋徹行、土方貴雄
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K06873
[Presentation] ESR1発現欠損による乳がん悪性化の分子機序の解析2018
- Author(s)
  71)青木寧々、青木夏美、木田ほのか、上原久典、高橋徹行、土方貴雄
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K06873
[Presentation] Hyperinsulinemia, not hyperglycemia accelerates the progression of hepatocellular carcinoma in neonatal streptozotocin induced mouse model.2017
- Author(s)
  Koichi Tsuneyama, Ryosuke Bessho, Masahiro Miki, Hayato Baba, Tetsuyuki Takahashi, Hirohisa Ogawa, Hisanori Uehara
- Organizer
  The 68th Annual Meeting of American Association for the Study of Liver Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06873
[Presentation] プロスタグランジンE2受容体シグナリング阻害は膵臓がんにおけるIGF-1受容体シグナリングを介した増殖刺激を消失させる2016
- Author(s)
  高橋徹行、上原久典、常山幸一、土方貴雄
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K06873
[Presentation] 骨における前立腺癌細胞の増殖へのlipolysis stimulated lipoprotein receptorの関与2016
- Author(s)
  上原　久典
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K08403
[Presentation] 脂肪細胞由来の FABP4 による前立腺癌細胞の骨内増殖促進2015
- Author(s)
  上原　久典、高橋　徹行
- Organizer
  第２４回日本がん転移学会学術集会・総会
- Place of Presentation
  シティプラザ大阪（大阪府大阪市中央区）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-15K08403
[Presentation] Effect of osteoprotegerin on growth of human prostate cancer cells in the bone of nude mice2007
- Author(s)
  UEHARA, Hisanori
- Organizer
  66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2007-10-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590373
[Presentation] Effect of osteoprotegerin on growth of human prostate cancer cells in the bone of nude mice2007
- Author(s)
  上原久典
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590373

1. 大豆本圭 (10745516)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
2. TAKAHASHI Tetsuyuki (00403692)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. KUSUHARA Yoshito (40745684)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. 宇都義浩 (20304553)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. 高橋正幸 (50325255)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. KANAYAMA Hiroomi (10214446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
7. 岩佐武 (00707903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 福原弥生 (10632490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 渡邊明子 (70898189)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 布川朋也 (70564342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 竹本龍也 (30443899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 片桐豊雅 (60291895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 常山幸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 佐々木雄太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uehara Hisanori 上原 久典

UEHARA Hisanori 上原 久典

上原 久典 ウエハラ ヒサノリ

Research Projects

Research Products

Co-Researchers

RCC Precision Medicine Project using PDX models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mutant p53 - Cancer Immunology Research from the DDX31 axis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Next Generation "Light" Fertility Treatment Using LEDs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a next-generation patient-derived cancer model using chicken eggs and establishment of a drug screening method

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel signaling crosstalk between prostaglandin E2 receptors and IGF-1 receptor as a possible molecular target for antitumor therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of fatty acid binding protein 4 (FABP4) as an exogenous ligand, on growth of prostate cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Trial of inhibition of prostate cancer cell growth in the bone using bone marrow-derived stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヌードマウス前立腺内および骨内におけるヒト前立腺癌細胞の転移関連遺伝子発現の比較Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 当院における患者由来PDXモデルを用いた取り組み-個別化医療を目指して-2023

Author(s)

Journal Title

Data Source

[Journal Article] Insulin receptor expression to predict resistance to axitinib and elucidation of the underlying molecular mechanism in metastatic renal cell carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 当院における患者由来PDXモデルを用いた取り組み-個別化医療を目指して-2023

Author(s)

Journal Title

Data Source

[Journal Article] 鶏卵を用いた次世代患者由来がんモデルの開発2020

Author(s)

Journal Title

Data Source

[Journal Article] Adipose tissue:Critical contributor to the development of prostate cancer2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.2017

Uehara Hisanori 上原久典

UEHARA Hisanori 上原久典

上原久典ウエハラヒサノリ

[Presentation] 射精障害に対してOnce　TESEを施行した進行性精巣腫瘍の1例2022

[Presentation] 当科における患者腫瘍組織移植PDX（patient-derived xenograft)モデル作製の取り組みとMicropapillary urothelial carcinomaのPDX　modelの樹立2019