Adachi Noritaka 足立典隆

… Alternative Names

ADACHI Noritaka 足立典隆

Less

Researcher Number	30264675
Other IDs
Affiliation (Current)	2022: 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授
Affiliation (based on the past Project Information) *help	2013 – 2022: 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 2015: 横浜市立大学, 生命ナノシステム科学研究科, 教授 2012: 横浜市立大学, 生命ナノシステム研究科, 教授 2010 – 2012: 横浜市立大学, 生命ナノシステム科学研究科, 教授 2009: Yokohama City University, 生命ナノシステム科学研究科, 准教授 … More 2007 – 2008: Yokohama City University, International Graduate School of Arts and Sciences, Associate Professor 2006: 横浜市立大学, 木原生物学研究所, 準教授 1998 – 2005: 横浜市立大学, 木原生物学研究所, 助手 2004: Yokohama City University, Kihara Institute for Biological Research, Dev. Mol. Cell Genetics, Assistant Professor, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Biological pharmacy / Biological pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields / Applied genomics / System genome science / Medium-sized Section 63:Environmental analyses and evaluation and related fields Except Principal Investigator Biological Sciences / Molecular biology / Hematology / Risk sciences of radiation and chemicals
Keywords	Principal Investigator ジーンターゲティング / トポイソメラーゼ / エンドジョイニング / DNA鎖切断 / 非相同組換え / DNA修復 / Nalm-6 / ノックアウト / 遺伝子ノックアウト / DT40 … More / ランダムインテグレーション / ヒト遺伝子 / 逆遺伝学的解析 / ゲノム改変 / ゲノム編集 / 細胞増殖 / プロモーター / NF-Y / アセチル化 / 細胞周期 / DNAライゲース / Ku / FEN-1 / DNAトポイソメラーゼ / DNA ligase / 塩基除去修復 / トポイソラーゼ / 化学療法 / DNA損傷 / p53 / TDP1 / DNA損傷応答 / 逆遺伝的解析 / DNA鎖切断修復 / 組換え / NDA鎖切断 / ゲノム切断修復 / クロマチン構造 / ランダム挿入 / FACS解析 / ジーンターゲティンク / 非相同組換之 / DNA strand break / DNA repair / end-ioining / random integration / gene targeting / nonhomologous recombination / ヒトゲノム / ゲノム修復 / 非相同末端連結 / DNAポリメラーゼ / NHEJ / 組換え修復 / DNA切断 / ゲノム編集細胞 / 生体環境 / 組換え修復 / 遺伝子発現 / がん … More Except Principal Investigator ヒト細胞 / ジーンターゲティング / ブルーム症候群 / 非相同的末端連結 / BLM / DNAリガーゼIV / KU70 / がん / 塩基除去修復 / FEN1 / 癌 / Ku70 / ノックアウト細胞 / APRT遺伝子 / 突然変異 / 有糸分裂組換え / 条件致死変異株 / エピジェネティックメモリー / ヒストンH3.3 / 細胞分化 / マクロファージ / 網羅的解析 / 国際情報交流 / 米国 / 転写 / DNAポリメラーゼβ / TEN1 / ニワトリDT40細胞 / 組換え能 / 薬剤感受性 / 塩基除去修復活性 / シーンターゲティング / 非相同組換え / 相同組換え / BER活性 / Base excision repair / DNA polymerase beta / chicken DT40 cell / Gene targeting / knockout cell / Short-patch BER / Long-patch BER / 遺伝学 / 遺伝子 / ゲノム / 修復 / 遺伝子破壊株 / 組換え修復 / 遺伝子相互作用 / ゲノム不安定性 / genetics / gene / cancer / genome / repair / DNA repair / NHEJ / DNA-PKcs / DNA依存性プロテインキナーゼ / 非相同末端連結 Less

条件的遺伝子発現系の理論的構築による新規DNA修復欠損がん診断・治療戦略の開発Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Yokohama City University
生体環境からみたゲノム組換え修復に関する包括的理解Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Yokohama City University
Efficient suppression of random DNA integrationPrincipal Investigator
- Principal Investigator
  
  Adachi Noritaka
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Yokohama City University
Development of high-efficiency gene targeting technologiesPrincipal Investigator
- Principal Investigator
  
  Noritaka Adachi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  System genome science
- Research Institution
  Yokohama City University
Genes that enable high-efficiency gene disruption in human cellsPrincipal Investigator
- Principal Investigator
  
  Adachi Noritaka
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama City University
Role of DNA-PKcs in neurogenesis
- Principal Investigator
  
  Kurosawa Aya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Yokohama City University
Development and applications of high-efficiency gene targeting in human cellsPrincipal Investigator
- Principal Investigator
  
  ADACHI NORITAKA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied genomics
- Research Institution
  Yokohama City University
Analysis of human genes that enable high-efficiency gene targetingPrincipal Investigator
- Principal Investigator
  
  ADACHI Noritaka
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama City University
ゲノム切断修復におけるクロマチン構造の役割Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Epigenetic marking by histone variant H3.3 during myeloid cell differentiation
- Principal Investigator
  
  TAMURA Tomohiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Yokohama City University
GeneticanalysisofDNAstrandbreakrepairinhumancelIsPrincipal Investigator
- Principal Investigator
  
  ADACHI Noritaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama City University
ヒト遺伝子ノックアウトシステムの効率化と疾患遺伝子機能解析への応用Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
ヒト染色体DNA切断とその修復機構Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
ヒトDNA鎖切断修復の逆遺伝学的解析と医療への応用Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
ヒト染色体DNA切断とその修復機構Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Genetic studies on the interaction between base excision repair and recombinational repair using human gene knockout cells
- Principal Investigator
  
  KOYAMA Hideki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
Analysis of DNA strand break repair using human knockout cellsPrincipal Investigator
- Principal Investigator
  
  ADACHI Noritaka
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama City University
ヒト遺伝子の系統的な機能解析に向けた高効率ジーンターゲティング系の開発
- Principal Investigator
  
  小山秀機
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
ヒトプレB細胞よりBLM破壊株の作製とその非相同組換え能の解析
- Principal Investigator
  
  小山秀機
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
トポイソメラーゼ阻害剤によるゲノム損傷の修復におけるDNA鎖切断修復機構の役割Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
動物細胞のDNA鎖切断修復と非相同組換えに関する逆遺伝学的解析Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama City University
ヒトプレB細胞よりBLM破壊株の作製とそ非相同的末端連結能の解析
- Principal Investigator
  
  KOYAMA Hideki
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Studies of base excision repair in cell mutants deficient. in either DNA polymerase, or flap endonuclease-1 or both, generated from chicken DT40 cells.
- Principal Investigator
  
  KOYAMA Hideki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University, Kihara Institute for Biological Research
DT40細胞を用いた非相同組換え機構の遺伝的解析Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama City University
ニワトリDT40細胞を用いた非相同組換え機構の遺伝的解析Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama City University
DNAトポイソメラーゼIIαの生理的機能と発現制御機構Principal Investigator
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama City University

[Journal Article] Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells2021
- Author(s)
  Suzuki Tetsuya、Sassa Akira、Gruz Petr、Gupta Ramesh C.、Johnson Francis、Adachi Noritaka、Nohmi Takehiko
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 100 Pages: 103052-103052
- DOI
  10.1016/j.dnarep.2021.103052
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12339, KAKENHI-PROJECT-19H01151
[Journal Article] Complex genetic interactions between DNA polymerase β and the NHEJ ligase.2020
- Author(s)
  Kurosawa A, Kuboshima H, Adachi N.
- Journal Title
  
  FEBS Journal
  
  Volume: 287 Pages: 377-385
- DOI
  10.1111/febs.15012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01151, KAKENHI-PROJECT-18K19407
[Journal Article] Dynamic behavior of DNA topoisomerase IIβ in response to DNA double-strand breaks2018
- Author(s)
  Morotomi-Yano K, Saito S, Adachi N, Yano KI.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 10344-10344
- DOI
  10.1038/s41598-018-28690-6
- NAID
  120006697280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19407, KAKENHI-PROJECT-16K01363
[Journal Article] TBP-like protein (TLP) disrupts the p53-MDM2 interaction and induces long-lasting p53 activation.2017
- Author(s)
  Maeda R., Tamashira H., Takano K., Takahashi H., Suzuki H., Saito S., Hojima W., Adachi N., U ra K ., E ndo T . and *Tam ura T.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Pages: 3201-3212
- DOI
  10.1074/jbc.m116.763318
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01345, KAKENHI-PROJECT-15H04323, KAKENHI-PROJECT-15H04348, KAKENHI-PROJECT-15J02670, KAKENHI-PROJECT-16J04091, KAKENHI-PROJECT-26440045
[Journal Article] Dual loss of human POLQ and LIG4 abolishes random integration.2017
- Author(s)
  Saito S, Maeda R, Adachi N.
- Journal Title
  
  Nature Commun.
  
  Volume: 8
- DOI
  10.1038/ncomms16112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04323
[Journal Article] Mechanistic basis for increased human gene targeting by promoterless vectors: roles of homology arms and Rad54 paralogs.2017
- Author(s)
  Saito S, Kurosawa A, Adachi N.
- Journal Title
  
  FEBS J.
  
  Volume: 284 Pages: 2748-2763
- DOI
  10.1111/febs.14137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04323
[Journal Article] Non-homologous DNA end joining and alternative pathways to double-strand break repair.2017
- Author(s)
  Chang HHY, Pannunzio NR, Adachi N, Lieber MR.
- Journal Title
  
  Nature Rev. Mol. Cell Biol.
  
  Volume: 18 Pages: 495-506
- DOI
  10.1038/nrm.2017.48
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04323
[Journal Article] Dual loss of human POLQ and LIG4 abolishes random integration2017
- Author(s)
  Saito S, Maeda R, Adachi N.
- Journal Title
  
  Nat. Commun.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04323
[Journal Article] Advances in the Development of Gene-Targeting Vectors to Increase the Efficiency of Genetic Modification2016
- Author(s)
  Saito S, Adachi N.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 39 Issue: 1 Pages: 25-32
- DOI
  10.1248/bpb.b15-00701
- NAID
  130005116505
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04323, KAKENHI-PROJECT-26670031
[Journal Article] Mutations in XRCC4 cause primordial dwarfism without causing immunodeficiency.2016
- Author(s)
  Saito S, Kurosawa A, Adachi N.
- Journal Title
  
  J. Hum. Genet.
  
  Volume: 印刷中 Pages: 679-685
- DOI
  10.1038/jhg.2016.46
- NAID
  40020923702
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04323
[Journal Article] Construction and applications of exon-trapping gene-targeting vectors with a novel strategy for negative selection.2015
- Author(s)
  Saito S, Ura K, Kodama M, Adachi N.
- Journal Title
  
  BMC Res. Notes
  
  Volume: 8 Pages: 278-278
- DOI
  10.1186/s13104-015-1241-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04323, KAKENHI-PROJECT-26670031
[Journal Article] Role for Artemis nuclease in the repair of radiation-induced DNA double strand breaks by alternative end joining.2015
- Author(s)
  Moscariello M, Wieloch R, Kurosawa A, Li F, Adachi N, Mladenov E, Iliakis G.
- Journal Title
  
  DNA Repair
  
  Volume: 31 Pages: 29-40
- DOI
  10.1016/j.dnarep.2015.04.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24310149
[Journal Article] Role for Artemis nuclease in the repair of radiation-induced DNA double strand breaks by alternative end joining.2015
- Author(s)
  Moscariello M, Wieloch R, Kurosawa A, Li F, Adachi N, Mladenov E, Iliakis G.
- Journal Title
  
  DNA Repair
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670031
[Journal Article] Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells2015
- Author(s)
  Ishii T, Hayakawa H, Sekiguchi T, Adachi N, Sekiguchi M.
- Journal Title
  
  ree Radical Biology and Medicine
  
  Volume: 79 Pages: 109-116
- DOI
  10.1016/j.freeradbiomed.2014.11.018
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24310149, KAKENHI-PROJECT-24570160, KAKENHI-PROJECT-26340040, KAKENHI-PROJECT-26670031
[Journal Article] Analysis of the role of homology arms in gene-targeting vectors in human cells.2014
- Author(s)
  Ishii A, Kurosawa A, Saito S, Adachi N.
- Journal Title
  
  PLoS ONE
  
  Volume: 9
- DOI
  10.1371/journal.pone.0108236
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24310149, KAKENHI-PROJECT-26670031
[Journal Article] In vivo evidence that phenylalanine l7l acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase kappa2014
- Author(s)
  A. Sassa, T. Suzuki, Y. Kanemaru, N. Niimi, H. Fujimoto, A. Katafuchi, P. Gruz, M. Yasui, R.C. Gupta, F. Johnson, T. Ohta, M. Honma, N. Adachi and T. Nohmi
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 15 Pages: 21-28
- DOI
  10.1016/j.dnarep.2013.12.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22241016, KAKENHI-PROJECT-24659035, KAKENHI-PROJECT-25281022, KAKENHI-PROJECT-25340044
[Journal Article] C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin2013
- Author(s)
  Liu S, Liu X, Kamdar RP, Wanotayan R, Sharma MK, Adachi N, Matsumoto Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 439 Pages: 173-178
- DOI
  10.1016/j.bbrc.2013.08.068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390290, KAKENHI-PROJECT-24659035
[Journal Article] DNA ligase IV and Artemis act cooperatively to suppress homologous recombination in human cells: Implications for DNA double-strand break repair.2013
- Author(s)
  Kurosawa A, Saito S, So S, Hashimoto M, Iwabuchi K, Watabe H, Adachi N.
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- DOI
  10.1371/journal.pone.0072253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310041, KAKENHI-PROJECT-23510067, KAKENHI-PROJECT-24310149, KAKENHI-PROJECT-24651056, KAKENHI-PROJECT-24659035
[Journal Article] Both CpG methylation and AID are required for the fragility of the human Bcl-2 major breakpoint region: Implications for the timing of the breaks in the t(14;18)2013
- Author(s)
  N. Adachi, et al.
- Journal Title
  
  Mol. Cell. Biol
  
  Volume: 33 Pages: 947-957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310149
[Journal Article] Repair of accidental DNA double-strand breaks in the human genome and its relevance to vector DNA integration2013
- Author(s)
  Adachi N,Saito S,Kurosawa A
- Journal Title
  
  Gene Technology
  
  Volume: 3
- DOI
  10.4172/2329-6682.1000e107
- Data Source
  KAKENHI-PROJECT-24659035
[Journal Article] Generation and use of genetically modified human cell lines : a promising approach for in vitro toxicology studies2013
- Author(s)
  Adachi N
- Journal Title
  
  J Clinic Toxicol
  
  Volume: 3(5) Pages: 45-45
- DOI
  10.4172/2161-0495.s1.009
- Data Source
  KAKENHI-PROJECT-24659035
[Journal Article] Interference in DNA replication can cause mitotic chromosomal breakage unassociated with doublestrand breaks.2013
- Author(s)
  Fujita Mari, Sasanuma H, Kimiyo N. Yamamoto Harada H, Kurosawa A, Adachi N, Omura M, Hiraoka M, Takeda S, Hirota K.
- Journal Title
  
  PLOS ONE
  
  Volume: 8 Pages: 60043-60043
- DOI
  10.1371/journal.pone.0060043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06811, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23659152, KAKENHI-PUBLICLY-24114509, KAKENHI-PROJECT-24659035, KAKENHI-PROJECT-25281021
[Journal Article] Restoration of mismatch repair functions in human cell line Nalm-6, which has high efficiency for gene targeting.2013
- Author(s)
  Adachi N. et al.
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659035
[Journal Article] Endogenous factors causative of spontaneous DNA damage that leads to random integration in human cells2013
- Author(s)
  N. Adachi et al.
- Journal Title
  
  Gene Technology
  
  Volume: 2 Pages: 105-105
- DOI
  10.4172/2329-6682.1000105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310149, KAKENHI-PROJECT-24659035
[Journal Article] Restoration of mismatch repair functions in human cell line nalm-6, which has high efficiency for gene targeting2013
- Author(s)
  T. Suzuki, A. Ukai, M. Honma, N. Adachi and T. Nohmi
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0061189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241016, KAKENHI-PROJECT-24659035
[Journal Article] Both CpG methylation and AID are required for the fragility of the human Bcl-2 major breakpoint region : Implications for the timing of the breaks in the t(l4;l8)2013
- Author(s)
  Cui X,Lu Z,Kurosawa A,Klemm L,Bagshaw A,Tsai A,Gemmell N,Muschen M,Adachi N,Hsieh CL,Lieber MR
- Journal Title
  
  Mol Cell Biol
  
  Volume: 33(5) Pages: 947-57
- DOI
  10.1128/mcb.01436-12
- Data Source
  KAKENHI-PROJECT-24659035
[Journal Article] Model for MLL translocations in therapy-related leukemia involving topoisomerase IIbeta mediated DNA strand breaks and gene proximity2012
- Author(s)
  Cowell IG,Sondka Z,Smith K,Lee KC,Manville CM,Sidorczuk-Lesthuruge M,Rance HA,Padget K,]ackson GH,Adachi N,Austin CA
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 109(23) Pages: 8989-94
- DOI
  10.1073/pnas.1204406109
- Data Source
  KAKENHI-PROJECT-24659035
[Journal Article] The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation2012
- Author(s)
  Kohzaki M
- Journal Title
  
  Carcinogenesis
  
  Volume: 33 Pages: 1203-10
- DOI
  10.1093/carcin/bgs149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-24659035
[Journal Article] Nucleofection-based gene targeting in human pre-B cells2012
- Author(s)
  Kurosawa A, Adachi N
- Journal Title
  
  Gene
  
  Volume: 492 Pages: 305-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Nucleofection-based gene targeting in human pre-B cells2012
- Author(s)
  Kurosawa, A., Adachi, N.
- Journal Title
  
  Gene
  
  Volume: 492 Pages: 305-308
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23131511
[Journal Article] The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation2012
- Author(s)
  Adachi N., et al
- Journal Title
  
  Carcinogenesis
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Artemis C-terminal region facilitates efficient V(D)] recombination through its interaction with both DNA Ligase IV and DNA-PKcs2012
- Author(s)
  N. Adachi, et al.
- Journal Title
  
  J Exp Med
  
  Volume: 209 Pages: 955-63
- DOI
  10.1084/jem.20111437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310149, KAKENHI-PROJECT-24659035
[Journal Article] LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs2012
- Author(s)
  Adachi N., et al
- Journal Title
  
  PLoS Pathogens
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Impaired cell adhesion, apoptosis, and signaling in WASP genedisrupted Nalm-6 pie-B cells and recovery of cell adhesion using a transducible form of WASp2012
- Author(s)
  Sate R, Iiizumi S, Kim ES, Honda F, Lee SK, Adachi N, Koyama H, Mizutani S, Morie T.
- Journal Title
  
  Int J Hematol
  
  Volume: 95 Pages: 299-310
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] EDGF/pisindependent HIV-l repli cation demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs2012
- Author(s)
  Schrijvers R, De Rijck J, Demeu lemeester J, Adachi N, Vets S, Ronen K, Christ F, Bushman FD, Debyser Z, Gt jsbers R.
- Journal Title
  
  PLoS Pathog
  
  Volume: 8 Pages: 1002558-1002558
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Model for MLL translocations in therapy-related leukemia involving topoisomerase IIbeta mediated DNA strand breaks and gene proximity.2012
- Author(s)
  Adachi N. et al.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 109 Pages: 8989-8994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659035
[Journal Article] Nucleofection-based gene targeting in human pie-B cells2012
- Author(s)
  Kurosawa A, Saito S, Mort M, Adachi N.
- Journal Title
  
  Gene
  
  Volume: 492 Pages: 305-308
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Highefficiency gene tar geting in a human pie-B cell line : towards the human gene knockout project2010
- Author(s)
  Adachi N.
- Journal Title
  
  Genome Biol
  
  Volume: 11 Pages: 1-1
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Chromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors2010
- Author(s)
  Adachi, N., et al.
- Journal Title
  
  PLoS ONE 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] OGFODl, a member of the 2oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling2010
- Author(s)
  Saito K, Adachi N, Koyama H, Matsushita M.
- Journal Title
  
  FEBS Left
  
  Volume: 584 Pages: 3340-3347
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Functions and regulation of Artemis : A goddess in the maintenance of genome integrity.2010
- Author(s)
  Kurosawa A, Adachi N.
- Journal Title
  
  J.Radiat.Res.
  
  Volume: 51 Pages: 503-509
- NAID
  10026644156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] FENl functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells2010
- Author(s)
  Asagoshi K, Tana K, Chastain PD II, Adachi N, Sonoda E, Kikuchi K, Koyama H, NagataK, Kaufman DG, Takeda S, Wilson SH, Watanabe M, Swenberg JA, Nakamura J.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 8 Pages: 204-215
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Functions and regulation of Artemis : A goddess in the maintenance of genome integrity2010
- Author(s)
  Kurosawa A, Adachi N.
- Journal Title
  
  J Radiat Res
  
  Volume: 51 Pages: 503-509
- NAID
  10026644156
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Chromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors.2010
- Author(s)
  Adachi, N., et al.
- Journal Title
  
  PLoS ONE 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018022
[Journal Article] Functions and regulation of Artemis : A goddess in the maintenance of genome integrity2010
- Author(s)
  Kurosawa, A., Adachi, N.
- Journal Title
  
  J.Radiat.Res. 51(印刷中)
- NAID
  10026644156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells2010
- Author(s)
  Adachi, N., et al.
- Journal Title
  
  Mol.Cancer Res. 8
  
  Pages: 204-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] FFN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells.2010
- Author(s)
  Adachi, N., et al.
- Journal Title
  
  Mol.Cancer Res. 8
  
  Pages: 204-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20055017
[Journal Article] Functions and regulation of Artemis : A goddess in the maintenance of genome integrity.2010
- Author(s)
  Kurosawa, A., Adachi, N.
- Journal Title
  
  J.Radiat.Res. 51(印刷中)
- NAID
  10026644156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20055017
[Journal Article] Chromosomal manipulation by sitespecific recombinases and fluore scent protein-based vectors2010
- Author(s)
  Uemura M, Niwa Y, Kakazu N, Adachi N, Kinoshita K.
- Journal Title
  
  PLoS ONE
  
  Volume: 5 Pages: 9846-9846
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Loss of Bloom syndrome protein destabilizes human gene cluster architecture.2009
- Author(s)
  Adachi, N., et al.
- Journal Title
  
  Hum.Mol.Genet. 18
  
  Pages: 3417-3428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20018022
[Journal Article] Genetic evidence that the nonhomologous endjoining repair pathway is involved in LINE retro transposition2009
- Author(s)
  Suzuki J, Yamaguchi K, Kajikawa M, Ichiyanagi K, Adachi N, Koyama H, Takeda S, Okada N.
- Journal Title
  
  PLoS Genetics
  
  Volume: 5 Pages: 1000461-1000461
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Heterozygous disruption of the DNA topoisomerase I gene confers cellular resistance to camptothecin in human cells2009
- Author(s)
  Toyoda E, Kurosawa A, Fu j i i M, Adachi N.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 32 Pages: 724-727
- NAID
  110007160669
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Molecular mechanism of protein assembly on DNA double strand breaks in the nonhomologous endjoining pathway2009
- Author(s)
  Yano K, Morotomi-Yano K, Adachi N, Akiyama H.
- Journal Title
  
  J Radiat Res
  
  Volume: 50 Pages: 97-108
- NAID
  10025911271
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Loss of Bloom syndrome protein destabilizes human gene cluster architecture2009
- Author(s)
  Killen MW, Stults DM, Adachi N, Hanakahi L, Pierce AJ.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 18 Pages: 3417-3428
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomer ase-Ilalpha in breast cancer cells2009
- Author(s)
  Rae VA, Klein SR, Agama KK, Toyoda E, Adachi N, Pommier YG, Shacter EB.
- Journal Title
  
  Cancer Res
  
  Volume: 69 Pages: 948-957
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Topoisomerase Ilalpha inhib ition following DNA transfection greatly enhances random integration in a human pie-B lymphocyte cell line2009
- Author(s)
  Toyoda E, Kurosawa A, Kamekawa H, Adachi N.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 382 Pages: 492-496
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination.2006
- Author(s)
  Adachi, N., et. al.
- Journal Title
  
  DNA Cell Biol 25
  
  Pages: 19-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590063
[Journal Article] The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination.2006
- Author(s)
  Adachi, N. et al.
- Journal Title
  
  DNA Cell Biol. 25(1)
  
  Pages: 19-24
- Data Source
  KAKENHI-PROJECT-16790058
[Journal Article] The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination2006
- Author(s)
  Adachi, N., et. al.
- Journal Title
  
  DNA Cell Biol. 25
  
  Pages: 19-24
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590063
[Journal Article] The human pre-B cell line Nalm-6 in highly proficient in gene targeting by homologous recombination.2006
- Author(s)
  Adachi, N.
- Journal Title
  
  DNA Cell Biol. 25
  
  Pages: 19-24
- Data Source
  KAKENHI-PROJECT-18570163
[Journal Article] Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediate DNA damage.2005
- Author(s)
  Adachi, N.
- Journal Title
  
  DNA Cell Biol. 24
  
  Pages: 388-393
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage.2005
- Author(s)
  Adachi, N.et al.
- Journal Title
  
  DNA Cell Biol. (in press)
- Data Source
  KAKENHI-PROJECT-16023257
[Journal Article] Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage.2005
- Author(s)
  Adachi, N. et al.
- Journal Title
  
  DNA Cell Biol. (In press)
- Data Source
  KAKENHI-PROJECT-16790058
[Journal Article] Edivence for a role of vertebrate Rad52 in the repaire of topoisomerase II-mediated DNA damage2005
- Author(s)
  Adachi, N., Iiizumi, S., Koyama, H.
- Journal Title
  
  DNA Cell Biol. 24
  
  Pages: 388-393
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.2004
- Author(s)
  Adachi, N. et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 318
  
  Pages: 856-861
- Data Source
  KAKENHI-PROJECT-16790058
[Journal Article] Loss of nonhomologous end-joining confers camptothecin resistance in DT40 cells Implications for the repair of topoisomerase I-mediated DNA damage.2004
- Author(s)
  Adachi, N.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 37343-37348
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Loss of nonhomologous end-joining confers camptothecin resistance in DT40 cells--Implications for the repair of topoisomerase I-mediated DNA damage.2004
- Author(s)
  Adachi, N. et al.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 37343-37348
- Data Source
  KAKENHI-PROJECT-16790058
[Journal Article] Loss of nonhomologous end-joining confers camptothecin resistance in DT40 Cells. Implications for the repair of topoisomerase I-mediated DNA damage.2004
- Author(s)
  Adachi, N.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 37343-37348
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.2004
- Author(s)
  Adachi, N.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 318
  
  Pages: 856-861
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.2004
- Author(s)
  Adachi, N.
- Journal Title
  
  Biochem Biophys.Res.Commun. 318
  
  Pages: 856-861
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Loss of nonhomologous end-joining confers camptothecin resistance in DT40 cells: Implications for the repair of topoisomerase I-mediated DNA damage2004
- Author(s)
  Adachi, N., So, S., Koyama, H.
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages: 37343-37348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Loss of nonhomologous end-joining confers camptothecin resistance in DT40 cells : Implications for the repair of topoisomerase I-mediated DNA damage.2004
- Author(s)
  Adachi, N.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 37343-37348
- Data Source
  KAKENHI-PROJECT-16021247
[Journal Article] Loss of nonhomologous end-joining confers camptothecin resistance in DT40 cells--Implications for the repair of topoisomerase I-mediated DNA damage.2004
- Author(s)
  Adachi, N.et al.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 37343-37348
- Data Source
  KAKENHI-PROJECT-16023257
[Journal Article] Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.2004
- Author(s)
  Adachi, N.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 318
  
  Pages: 856-861
- Data Source
  KAKENHI-PROJECT-16012252
[Journal Article] Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage2004
- Author(s)
  Adachi, N., Iiizumi, S., So, S., Koyama, H.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 318
  
  Pages: 856-861
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.2004
- Author(s)
  Adachi, N.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 318
  
  Pages: 856-861
- Data Source
  KAKENHI-PROJECT-16021247
[Journal Article] Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.2004
- Author(s)
  Adachi, N.et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 318
  
  Pages: 856-861
- Data Source
  KAKENHI-PROJECT-16023257
[Journal Article] Loss of nonhomologous end-joining confers camptothecin resistance in DT40 cells : Implications for the repair of topoisomerase I-mediated DNA damage.2004
- Author(s)
  Adachi, N.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 37343-37348
- Data Source
  KAKENHI-PROJECT-16012252
[Journal Article] Genetic interactions between BLM and the nonhomologous end-joining pathway in human cells2004
- Author(s)
  So, S., Adachi, N., Lieber, M., Koyama, H.
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages: 55433-55442
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase II α2003
- Author(s)
  Akimitsu, N., Adachi, N., Hirai, H., Hossain, M.S., Hamamoto, H., Kobayashi, M., Aratani, Y.Koyama, H., Sekimizu, K.
- Journal Title
  
  Gene Cells 8
  
  Pages: 393-402
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193-Imprications for repair of topoisomerase II-mediated DNA damage2003
- Author(s)
  Adachi, N., Suzuki, H., Iizumi, S., Koyama, H.
- Journal Title
  
  J. Biol. Chem. 278
  
  Pages: 35897-35902
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Model for MLL translocations in therapyrelated leukemia involving topoisomerase Ilbeta mediated DNA strand breaks and gene proximity
- Author(s)
  DCowell IG, Sondka Z, Smith K, Lee KC, Manville CM, SidorczukLesthuruge M, Rance HA, Padget K, Jackson GH, Adachi N, Austin CA.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediate DNA damage.
- Author(s)
  Adachi, N.
- Journal Title
  
  DNA Cell Biol. (In press)
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage.
- Author(s)
  Adachi, N.
- Journal Title
  
  DNA Cell Biol. (in press)
- Data Source
  KAKENHI-PROJECT-16021247
[Journal Article] Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage.
- Author(s)
  Adachi, N.
- Journal Title
  
  DNA Cell Biol. (in press)
- Data Source
  KAKENHI-PROJECT-16012252
[Journal Article] The helicase domain and Cterminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation
- Author(s)
  Kohzaki M, Chiourea M, Versini G, Adachi N, Takeda S, Gages S, Halazonetis TD.
- Journal Title
  
  Carcinogenesis
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21590066
[Journal Article] Artemis Cterminal region facilitates efficient V(D) J recombination through its interaction with both DNA Ligase IV and DNA-PKcs
- Author(s)
  Malu S, De loannes P, Kozlov M, Greene M, Francis, D, Hanna M, Pena, J, Escalante CR, Kurosawa A, ErdjumentBromage H, Tempst P, Adachi N, Vezzoni P, Villa A, Aggarwal AK, Certes P.
- Journal Title
  
  J Exp Med
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21590066
[Patent] 遺伝子ターゲティングベクター及びその利用方法2012
- Inventor(s)
  足立典隆
- Industrial Property Rights Holder
  足立典隆
- Filing Date
  2012-12-12
- Overseas
- Data Source
  KAKENHI-PROJECT-24310149
[Patent] 遺伝子ターゲティングベクター及びその利用方法2012
- Inventor(s)
  足立典隆
- Industrial Property Rights Holder
  足立典隆
- Industrial Property Rights Type
  特許
- Filing Date
  2012-12-12
- Overseas
- Data Source
  KAKENHI-PROJECT-24659035
[Patent] 遺伝子ターゲティングベクター、その作製方法及び利用方法2012
- Inventor(s)
  足立典隆
- Industrial Property Rights Holder
  足立典隆
- Industrial Property Rights Type
  特許
- Filing Date
  2012-05-24
- Overseas
- Data Source
  KAKENHI-PROJECT-24659035
[Patent] 遺伝子ターゲティングベクター, その作製方法及び利用方法2012
- Inventor(s)
  足立典隆
- Industrial Property Rights Holder
  足立典隆
- Filing Date
  2012-05-24
- Overseas
- Data Source
  KAKENHI-PROJECT-24310149
[Presentation] Functional analysis of human WHSC1 in DNA double-strand break repair2020
- Author(s)
  足立典隆、他
- Organizer
  日本環境変異原学会第49回大会
- Data Source
  KAKENHI-PROJECT-19H01151
[Presentation] DNA polymerase theta is essential for alternative end-joining2020
- Author(s)
  足立典隆、他
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01151
[Presentation] Introduction & Defining the mutation signatures of DNA polymerase θ in cancers2020
- Author(s)
  足立典隆
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01151
[Presentation] Role of Human DNA Polymerase θ at Double-Strand Breaks2018
- Author(s)
  Saito S., Adachi N.
- Organizer
  The 5th DNA polymerases meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19407
[Presentation] Regulatory role of human DNA-PKcs in DNA double-strand break repair2015
- Author(s)
  Watabe Haruka, Shinta Saito, Aya Kurosawa, Noritaka Adachi
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26740019
[Presentation] Gene knockout studies on DNA strand break repair in human cells2007
- Author(s)
  Adachi, N., et. al.
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590063
[Presentation] Gene knockout studies on DNA strand break repair in human cells2007
- Author(s)
  Adachi, N., et. al.
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590063
[Presentation] Gene knockout studies on DNA strand break repair in human cells2007
- Author(s)
  Adachi, N., et. al.
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570163
[Presentation] Gene knockout studies on DNA strand break repair in human cells2007
- Author(s)
  Adachi, N., et. al.
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570163
[Presentation] Impact of DSB repair deficiency on damage sensitivity: NHEJ negatively affects cell survival in the presence of DNA lesions that rely on homologous DNA repair2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  The Salk/Caltech conference on DNA. Replication and Genome Integrity
- Place of Presentation
  La Jolla (USA)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570163
[Presentation] Gene knockout studies on DNA double-strand break epair in human cells2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590063
[Presentation] Nonhomologous end-joining negatively affects cell survival in the presence of DNA lesions that rely on homologous DNA repair.2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  20th IUBMB Int'l and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590063
[Presentation] Nonhomologous end-joining negatively affects cell survival in the presence of DNA lesions that rely on homologous DNA repair2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  20th IUBMB Int'l and llth FAOBMB Congress
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570163
[Presentation] Gene knockout studies on DNA double-strand break repair in human cells.2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  JCA2006
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590063
[Presentation] Nonhomologous end-joining negatively affects cell survival in the resence of DNA lesions that rely on homoloous DNA repair2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  20th IUBMB Int'l Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570163
[Presentation] Gene knockout studies on DNA double-strand break repair in human cells2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  JCA2006
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570163
[Presentation] Impact of DSB repair deficiency on damage sensitivity:NHEJ negatively affects cell survival in the presence of DNA lesions that rely on homologous DNA repair2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  The Salk/Caltech conference on DNA Replication and Genome Integrity
- Place of Presentation
  La Jolla,CA,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590063
[Presentation] Impact of DSB repair deficiency on damage sensitivity: NHEJ negatively affects cell survival in the presence of DNA lesions that rely on homologous DNA repair.The Salk/Caltech conference on DNA.2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  Replication and Genome Integrity
- Place of Presentation
  La Jolla (USA)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590063
[Presentation] Gene knockout studies on DNA double-strand break repair in human cells2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570163
[Presentation] Nonhomologous end-joining negatively affects cell survival in the presence of DNA lesions that rely on homologous DNA repair2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  20th IUBMB Int'l Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590063
[Presentation] Impact of DSB repair deficiency on damage sensitivity:NHEJ negatively affects cell survival in the presence of DNA lesions that rely on homologous DNA repair2006
- Author(s)
  Adachi, N., et. al.
- Organizer
  The Salk/Caltech conference on DNA Replication and Genome Inteerity
- Place of Presentation
  La Jolla, CA, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570163

1. KOYAMA Hideki (40085626)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
2. TAMURA Tomohiko (50285144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NISHIYAMA Akira (80589664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Kurosawa Aya (70505867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. TAKANO Kazunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. IWABUCHI Kuniyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. SAJI Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. GRUZ Petr

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. Honma Masamitsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. Yasui Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. Suzuki Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. Sassa Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
13. 青田聖恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 遠藤剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 前田亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 高野晴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 松本義久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 橋本光正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 能美健彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 笹沼博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 武田俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 廣田耕志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 諸冨桂子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 関口猛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 早川浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 石井健士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 関口睦夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Adachi Noritaka 足立 典隆

ADACHI Noritaka 足立 典隆

Research Projects

Research Products

Co-Researchers

条件的遺伝子発現系の理論的構築による新規DNA修復欠損がん診断・治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生体環境からみたゲノム組換え修復に関する包括的理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Efficient suppression of random DNA integrationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of high-efficiency gene targeting technologiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genes that enable high-efficiency gene disruption in human cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of DNA-PKcs in neurogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development and applications of high-efficiency gene targeting in human cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of human genes that enable high-efficiency gene targetingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゲノム切断修復におけるクロマチン構造の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic marking by histone variant H3.3 during myeloid cell differentiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

GeneticanalysisofDNAstrandbreakrepairinhumancelIsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト遺伝子ノックアウトシステムの効率化と疾患遺伝子機能解析への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト染色体DNA切断とその修復機構Principal Investigator

Principal Investigator

Project Period (FY)

Adachi Noritaka 足立典隆

ADACHI Noritaka 足立典隆