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NAGAYAMA Yuji  永山 雄二

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Researcher Number 30274632
Other IDs
External Links
Affiliation (Current) 2025: 長崎大学, 原爆後障害医療研究所, 名誉教授
Affiliation (based on the past Project Information) *help 2012 – 2022: 長崎大学, 原爆後障害医療研究所, 教授
2012: 長崎大学, 医歯薬学総合研究科, 教授
2010 – 2011: Nagasaki University, 大学院・医歯薬学総合研究科, 教授
2008 – 2010: Nagasaki University, 医歯(薬)学総合研究科, 教授
2007: Nagasaki University, Graduate School of Biomedical Sciences, Professor … More
2006: 長崎大学, 大学院・医師薬学総合研究科, 教授
2006: Nagasaki University, Graduate School of Biomedical Sciences, Department of Medical Gene Technology, Atomic Bomb Disease Institute, professor, 大学院医歯薬学総合研究科, 教授
2003 – 2005: Nagasaki University, Graduate School of Biomedical Sciences Atomic Bomb Disease Institute Department of Medical Gene Technology, Professor, 大学院・医歯薬学総合研究科, 教授
2002: 長崎大学, 医歯薬学総合研究科, 助教授
2002: 長崎大学, 大学院・医歯薬学総合研究科, 助教授
2002: Nagasaki University, Graduate School of Biomedical and Sciences associate professor, 大学院・医歯薬総合研究科, 助教授
2000 – 2001: 長崎大学, 医学部, 助教授
1997 – 1998: 長崎大学, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
Endocrinology / Endocrinology / Basic Section 54040:Metabolism and endocrinology-related / 内分泌・代謝学
Except Principal Investigator
Plastic surgery / Basic Section 54040:Metabolism and endocrinology-related / Risk sciences of radiation and chemicals / Gastroenterology / Plastic surgery / General pharmacology / Endocrinology / Metabolomics
Keywords
Principal Investigator
バセドウ病 / TSH受容体 / アデノウイルス / マウスモデル / 甲状腺 / 自己免疫 / Graves' disease / adenovirus / サイトカイン / 甲状腺刺激ホルモン受容体 … More / thyrotropin receptor / 甲状腺自己免疫 / キナーゼ阻害剤 / 逆作動薬 / 遺伝子改変 / インバースアゴニスト / オートファジー / 甲状腺がん / autoantibody / regulatory T cells / thyroid autoimmunity / Autoantibody / TSH receptor / Thyroid autoimmunity / サトカイン / 自己抗体 / replication-competent adenovirus / Gene therapy / Thyroid carcinoma / p53 / 増殖型アデノウイルス / 増殖型アデノウィルス / 遺伝子治療 / 甲状腺癌 / subunit structure / glycosylation / acylation / post-translational modification / 免疫沈降法 / サブユニット構造 / 糖鎖 / アシル化 / 翻訳後修飾 / 国際情報交換、ドイツ / 国際情報交換:ドイツ:アメリカ / 橋本病 … More
Except Principal Investigator
ヒト間葉系幹細胞 / オートファジー / 甲状腺 / 放射線 / GITRL / PC61 / clinical application / human mesenchymal stem cells / 臨床応用 / サイトカイン / 血管新生 / vascular endothelial growth factor / MCP-1 / 癌 / PKCシグナル伝達経路 / 細胞死 / PKCシグナル伝達回路 / DNA二重鎖切断 / 酸化ストレス / 甲状腺ホルモン / TSH / アポトーシス / 発癌 / 内部被ばく / ジスルフィド結合 / RET/PTC / UV / 活性酸素種 / DNA損傷 / 発がん / ROS / cyclophosphamide / hepatoma / effector T cells(Teff) / regulatory T cells(Treg) / サイクロフォスファミド / 肝癌 / エフェクターT細胞 / 制御性T細胞 / facial bone growth / vessel and nerve regeneration / bone maturation marker / life-style oriented diseases / congenital anomaly / tissue regeneration and healing / human bone marrow-derived mesenchvmal stem cells / transfection / 膜性骨 / 頭蓋顔面骨 / 頭蓋顔面 / 成長期顔面骨 / 血管・神経再生 / 骨成熟マーカー / 生活習慣病 / 先天奇形 / 組織再生と治癒 / ヒト骨髄由来間葉系幹細胞 / トランスフェクション / fibroproliferative disease / cellular interaction / proliferation and differentiation / trans-differentiation / differentiation lineage / ヌードラット / 間葉系マーカー / 骨髄由来幹細胞 / 上皮転換 / 瘢痕の質 / 分子機構 / 臨床評価 / 水分量 / 骨髄間葉系幹細胞 / 創傷治癒 / 線維過剰 / 細胞相関 / 増殖と分化 / 超越分化 / 分化系列 / bone transcription factor / improvement of blood flow / angiogenesis / osteogenic cytokines / オステオカルシン / アルカリフォスファターゼ / 転写因子 / 骨マーカー / 移植床血行 / 血管柄付結合織膜弁 / 骨髄由来間葉系幹細胞 / 異所性骨 / 骨転写調節 / 血流改善 / 骨形成サイトカイン / mesenchymal to epithelial differentiation / cutaneous wound healing / mesenchymal stem cell / flap survival / signal transduction / keloid / 骨再生 / ケロイド / 細胞内情報伝達 / 分子生物学 / ATF-2 リン酸化 / TGF-β / IGF-1 / 初期増殖 / 幹細胞 / サイトカイン受容体操作 / 皮弁延長 / ATF-2リン酸化 / p38 / TGF-. / シグナル伝達 / 過剰創傷治癒 / hippocampus CA1 neurons / blood-brain barrier / endothelin receptor / endothelin / microglia / ischemia-related neuronal death / 脳血液関門 / 海馬CAI神経細胞 / vascular endothdial growth factor / 脳血液関門(BBB) / エンドセリン受容体 / エンドセリン / ミクログリア / 虚血性神経細胞死 / 癌-間質微小環境相互作用 / aldehyde dehydrogenase / 上皮間葉移行 / 微小環境 / 癌幹細胞 / 甲状腺癌 / 膵島自己抗原 / インスリンペプチド / poly:IC / poly I:C / 発症予防 / polyI : C / 経鼻免疫 / インスリン / NODマウス / 1型糖尿病 Less
  • Research Projects

    (18 results)
  • Research Products

    (164 results)
  • Co-Researchers

    (35 People)
  •  Autophagy regulatory mechanisms in thyroid and significance for carcinogenesis

    • Principal Investigator
      Kurashige Tomomi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Nagasaki University
  •  Studies on thyorid cancer pathogenesis using mouse modelsPrincipal Investigator

    • Principal Investigator
      NAGAYAMA Yuji
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Nagasaki University
  •  Elucidation of pathogenic mechanism of internal radiation-induced thyroid cancer

    • Principal Investigator
      KURASHIGE Tomomi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      Nagasaki University
  •  Studies on thyroid autoimmunity: anti-mouse TSH receptor immune response and central tolerance in micePrincipal Investigator

    • Principal Investigator
      NAGAYAMA Yuji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Nagasaki University
  •  Studies on thyroid autoimmunity: anti-TSHR immune response and tolerance in micePrincipal Investigator

    • Principal Investigator
      NAGAYAMA Yuji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Nagasaki University
  •  Cancer stem cells and cancer microenvironment in thyroid cancer

    • Principal Investigator
      YASUI Kazuaki
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Endocrinology
    • Research Institution
      Nagasaki University
  •  Development of treatment for the inhibition of type 1 diabetes

    • Principal Investigator
      ABIRU Norio
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Nagasaki University
  •  Studies on the pathogenesis of autoimmune thyroid diseases : using genetically-engineered micePrincipal Investigator

    • Principal Investigator
      NAGAYAMA Yuji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Nagasaki University
  •  Craniofecial bone reganeration by mesenchymal stem cells of the craniofacial origin

    • Principal Investigator
      HIRANO Akiyoshi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Plastic surgery
    • Research Institution
      Nagasaki University
  •  Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cells

    • Principal Investigator
      NAKAO Kazuhiko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagasaki University
  •  Studies on the pathogenesis of Graves' disease and new treatment using our recently established mouse model.Principal Investigator

    • Principal Investigator
      NAGAYAMA Yuji
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Nagasaki University
  •  Bone formation and optimal bone regeneration by using adult stem cells and endothelial progenitor cells and analysis of the molecular mechanism

    • Principal Investigator
      HIRANO Akiyoshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Plastic surgery
    • Research Institution
      Nagasaki University
  •  Bone formation and optimal bone regeneration by using adult stem cells and endothelial progenitor cells and analysis of the molecular mechanism

    • Principal Investigator
      AKITA Sadanori
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Plastic surgery
    • Research Institution
      Nagasaki University
  •  Studies on the poathogenesis of Graves' disease and new treatment using our recently established mouse model.Principal Investigator

    • Principal Investigator
      NAGAYAMA Yuji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Nagasaki University
  •  Regeneration of the wound healing sites basing on the molecular analysis and the tissue-engineered

    • Principal Investigator
      FUJII Tohru
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Plastic surgery
    • Research Institution
      NAGASAKI UNIVERSITY
  •  Evaluation of the therapeutic effect of replication-competent adenovirus on thyroid carcinomasPrincipal Investigator

    • Principal Investigator
      NAGAYAMA Yuji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Nagasaki University
  •  Microglial activation and blood-brain barrier function in ischemia-related neuronal death

    • Principal Investigator
      NIWA Masami
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      NAGASAKI UNIVERSITY
  •  Studies on structure-function of the thyrotropin receptor : molecular biological analysis of post-translational modificationsPrincipal Investigator

    • Principal Investigator
      NAGAYAMA Yuji
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Nagasaki University

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All Journal Article Presentation Book

  • [Book] Animal models of autoimmune thyroid disease. (In) Immunoendocrinology : Scientific and Clinical Aspects.2011

    • Author(s)
      Nagayama Y
    • Total Pages
      12
    • Publisher
      Humana Press
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Book] Immunoendocrinology : Scientific and Clinical Aspects.(Animal models of autoimmune thyroid disease.(In))(Eisenbarth G (ed))2011

    • Author(s)
      Nagayama Y.
    • Publisher
      Humana Press
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Book] The Proceeding for 13th International Congress of Endocrinology.2008

    • Author(s)
      Nagayama Y.
    • Publisher
      MEDIMOND INTERNATIONAL PROCEEDING
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Book] The Proceeding for 13th International Congress of Endocrinology.(Mouse models of Graves' disease)2008

    • Author(s)
      Nagayama Y.
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Characterization of metabolic reprogramming by metabolomics in the oncocytic thyroid cancer cell line XTC.UC1.2023

    • Author(s)
      Kurashige T, Shimamura M, Hamada K, Matsuse M, Mitsutake N, Nagayama Y.
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 149-160

    • DOI

      10.1038/s41598-023-27461-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07668, KAKENHI-PROJECT-19K09028
  • [Journal Article] The Effect of Long-Term Inorganic Iodine on Intrathyroidal Iodothyronine Content and Gene Expression in Mice with Graves' Hyperthyroidism2023

    • Author(s)
      Uchida Toyoyoshi、Shimamura Mika、Taka Hikari、Kaga Naoko、Miura Yoshiki、Nishida Yuya、Nagayama Yuji、Watada Hirotaka
    • Journal Title

      Thyroid

      Volume: 33 Issue: 3 Pages: 330-337

    • DOI

      10.1089/thy.2022.0496

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-19K11752
  • [Journal Article] Re-evaluation of the role of autophagy in thyroid cancer treatment2022

    • Author(s)
      Kazakova D, Shimamura M, Kurashige T, Hamada K, Nagayama Y.
    • Journal Title

      Endocr J

      Volume: 69 Issue: 7 Pages: 847-862

    • DOI

      10.1507/endocrj.EJ22-0017

    • NAID

      130008162464

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08888, KAKENHI-PROJECT-19K09028
  • [Journal Article] MIEAP and ATG5 are tumor suppressors in a mouse model of BRAFV600E-positive thyroid cancer2022

    • Author(s)
      Hamada Koichiro、Kurashige Tomomi、Shimamura Mika、Arakawa Hirofumi、Nakamura Yasuyuki、Nagayama Yuji
    • Journal Title

      Frontiers in Endocrinology

      Volume: 13 Pages: 932754-932754

    • DOI

      10.3389/fendo.2022.932754

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19412, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-20K08888, KAKENHI-PROJECT-23K24169, KAKENHI-PROJECT-19K07655
  • [Journal Article] Reprogramming of cellular metabolism and its therapeutic applications in thyroid cancer2022

    • Author(s)
      Nagayama Y, Hamada K
    • Journal Title

      Metabolites

      Volume: 12 Issue: 12 Pages: 1214-1214

    • DOI

      10.3390/metabo12121214

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Journal Article] Thyrotropin receptor antagonists and inverse agonists, and their potential application to thyroid diseases2022

    • Author(s)
      Nagayama Y, Nishihara E
    • Journal Title

      Endocr J

      Volume: 69 Issue: 11 Pages: 1285-1293

    • DOI

      10.1507/endocrj.EJ22-0391

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Journal Article] Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid2021

    • Author(s)
      Matsuyama M, Shichijo K, Matsuda K, Fujimoto N, Kondo H, Miura S, Kurashige T, Nagayama Y, Nakashima M.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 19096-19096

    • DOI

      10.1038/s41598-021-98481-z

    • NAID

      120007175565

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K10027, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-20K07424, KAKENHI-PROJECT-20K08886, KAKENHI-PROJECT-21K10399, KAKENHI-PROJECT-19KK0266
  • [Journal Article] Graves ' disease.2020

    • Author(s)
      Davies TF, Andersen S, Latif R, Nagayama Y, Barbesino G, Brito M, Eckstein AK, Green AS, Kahaly GJ.
    • Journal Title

      Nat Rev Dis Primers

      Volume: in press

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Journal Article] Acceleration of BRAFV600E-mediated thyroid carcinogenesis by TGFβ signal deficiency.2020

    • Author(s)
      Shimamura M, Kurashige T, Kuatov R, Nagayama Y.
    • Journal Title

      Endocrine

      Volume: in press Issue: 3 Pages: 571-577

    • DOI

      10.1007/s12020-020-02298-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-20K07424, KAKENHI-PROJECT-20K08886
  • [Journal Article] Re-evaluation of the effect of iodine on thyroid cell survival and function with PCCL3 and Nthy-ori 3-1 cells.2020

    • Author(s)
      Kurashige T, Shimamura M, Nagayama Y.
    • Journal Title

      Journal of Endocrine Society

      Volume: 4 (11) Issue: 11

    • DOI

      10.1210/jendso/bvaa146

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Journal Article] Autophagy and thyroid cancer.2020

    • Author(s)
      Nagayama Y
    • Journal Title

      Jounal of Cancer Metastasis and Treatment

      Volume: 7 Pages: 6-6

    • DOI

      10.20517/2394-4722.2020.114

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Journal Article] 甲状腺特異的オートファジーノックアウトマウスでは、濾胞上皮細胞死が誘導される2020

    • Author(s)
      永山 雄二 , 蔵重 智美 , 中島 康代 , 嶋村 美加 , 松山 睦美 , 中島 正洋 , 山田 正信
    • Journal Title

      日本内分泌学会雑誌

      Volume: 95 Pages: 1335-1335

    • Data Source
      KAKENHI-PROJECT-20K08888
  • [Journal Article] Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors.2020

    • Author(s)
      Mussazhanova Z, Shimamura M, Kurashige T, Ito M, Nakashima M, Nagayama Y
    • Journal Title

      Cancer Sci.

      Volume: 111 Issue: 8 Pages: 2814-2823

    • DOI

      10.1111/cas.14501

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-20K07424, KAKENHI-PROJECT-20K08886, KAKENHI-PROJECT-19KK0266
  • [Journal Article] Graves ' disease.2020

    • Author(s)
      Davies TF, Andersen S, Latif R, Nagayama Y, Barbesino G, Brito M, Eckstein AK, Green AS, Kahaly GJ.
    • Journal Title

      Nature Review Disease Primers

      Volume: 6 (1) Issue: 1 Pages: 52-52

    • DOI

      10.1038/s41572-020-0184-y

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Journal Article] Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice2019

    • Author(s)
      Kurashige Tomomi、Nakajima Yasuyo、Shimamura Mika、Matsuyama Mutsumi、Yamada Masanobu、Nakashima Masahiro、Nagayama Yuji
    • Journal Title

      Endocrinology

      Volume: 160 Issue: 9 Pages: 2085-2092

    • DOI

      10.1210/en.2019-00312

    • NAID

      120006988409

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-17K00554
  • [Journal Article] eterogenous nature of gene expression patterns in BRAF-like papillary thyroid carcinomas with BRAFV600E.2019

    • Author(s)
      Nagayama Y, Mishima H
    • Journal Title

      Endocrine

      Volume: 66 Issue: 3 Pages: 607-613

    • DOI

      10.1007/s12020-019-02063-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07850, KAKENHI-PROJECT-19K09028
  • [Journal Article] Long-term follow-up of a patient with sporadic non-autoimmune hyperthyroidism due to a thyrotropin receptor mutation (D619G).2018

    • Author(s)
      Nishihara E, Tsugawa M, Ozaki Y, Nagayama Y, Fukata S, Hirokawa M, Ito M, Nishikawa M, Nakamura H, Ito Y, Miyauchi A.
    • Journal Title

      AACE Clin Case Rep.

      Volume: 1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Journal Article] Intracellular redox status controls spherogenicity, an in vitro cancer stem cell marker, in thyroid cancer cell lines2018

    • Author(s)
      Shimamura Mika、Yamamoto Kazuo、Kurashige Tomomi、Nagayama Yuji
    • Journal Title

      Experimental Cell Research

      Volume: 370 Issue: 2 Pages: 699-707

    • DOI

      10.1016/j.yexcr.2018.07.036

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07235, KAKENHI-PROJECT-16K00548, KAKENHI-PROJECT-17K16167, KAKENHI-PROJECT-16H06276
  • [Journal Article] Mouse models of sporadic thyroid cancer derived from BRAFV600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels.2018

    • Author(s)
      Shimamura M, Shibusawa N, Kurashige T, Mussazhanova Z, Matsuzaki H, Nakashima M, Yamada M, Nagayama Y
    • Journal Title

      PloS one

      Volume: 13 Issue: 8 Pages: e0201365-e0201365

    • DOI

      10.1371/journal.pone.0201365

    • NAID

      120006987838

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K00548, KAKENHI-PROJECT-16K08702, KAKENHI-PROJECT-16K08714
  • [Journal Article] Radiation Related Thyroid Autoimmunity and Dysfunction.2018

    • Author(s)
      Nagayama Y
    • Journal Title

      J Radiat Res

      Volume: 印刷中

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Journal Article] バセドウ病研究の最近の進展.2017

    • Author(s)
      永山雄二
    • Journal Title

      医学のあゆみ

      Volume: 260(9) Pages: 711-715

    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Journal Article] バセドウ病と甲状腺機能異常:バセドウ病のモデル動物2017

    • Author(s)
      永山雄二
    • Journal Title

      最新医学社

      Volume: 72 (10) Pages: 38-43

    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Journal Article] N-Acetyl-L-cysteine protects thyroid cells against DNA damage induced by external and internal irradiation.2017

    • Author(s)
      Tomomi Kurashige, Mika Shimamura, Yuji Nagayama.
    • Journal Title

      Radiation and Environmental Biophysics

      Volume: 56 Issue: 4 Pages: 405-412

    • DOI

      10.1007/s00411-017-0711-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K00548, KAKENHI-PROJECT-15K09437
  • [Journal Article] Aldehyde dehydrogenase activity plays no functional role in stem cell-like properties in anaplastic thyroid cancer cell lines.2017

    • Author(s)
      Shimamura M, Kurashige T, Mitsutake N, Nagayama Y.
    • Journal Title

      Endocrine

      Volume: 55 Issue: 3 Pages: 934-943

    • DOI

      10.1007/s12020-016-1224-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-15K19535, KAKENHI-PROJECT-15K09437, KAKENHI-PROJECT-17K16167
  • [Journal Article] Targeted Foxe1 overexpression in mouse thyroid causes the development of multinodular goiter but does not promote carcinogenesis.2016

    • Author(s)
      Nikitski A, Saenko V, Shimamura M, Nakashima M, Matsuse M, Suzuki K, Rogounovitch T, Bogdanova T, Shibusawa N, Yamada M, Nagayama Y, Yamashita S, Mitsutake N
    • Journal Title

      Endocrinology

      Volume: 印刷中 Issue: 5 Pages: 2182-2195

    • DOI

      10.1210/en.2015-2066

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09438, KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293142, KAKENHI-PROJECT-15K09437, KAKENHI-PROJECT-16K08702, KAKENHI-PROJECT-16K09804, KAKENHI-PROJECT-16K09805
  • [Journal Article] Differences in quantification of DNA double-strand breaks assessed by 53BP1/γH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine.2016

    • Author(s)
      Kurashige T, Shimamura M, Nagayama Y.
    • Journal Title

      Journal of Radiation Research

      Volume: 印刷中 Issue: 3 Pages: 312-317

    • DOI

      10.1093/jrr/rrw001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26870440, KAKENHI-PROJECT-15K09437
  • [Journal Article] Cancer stem cells in the thyroid.2016

    • Author(s)
      Nagayama Y, Shimamura M, Mitsutake N.
    • Journal Title

      Frontiers in Endocrinology

      Volume: 7 Pages: 20-20

    • DOI

      10.3389/fendo.2016.00020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Journal Article] Expression of aldehyde dehydrogenase in normal and cancerous tissues of thyroids.2015

    • Author(s)
      Kurashige T, Shimamura M, Yasui K, Mitsutake N, Matsuse M, Nakashima M, Minami S, Eguchi S, Nagayama Y.
    • Journal Title

      Horm Metab Res.

      Volume: 47 (3) Issue: 03 Pages: 194-199

    • DOI

      10.1055/s-0034-1387770

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Journal Article] Animal models of Graves’ disease and Graves’ orbitopathy.2015

    • Author(s)
      Nagayama Y, Nakahara M, Abiru N.
    • Journal Title

      Curr Opin Endocrinol Diabetes Obes.

      Volume: 22 (5) Issue: 5 Pages: 381-386

    • DOI

      10.1097/med.0000000000000186

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09437, KAKENHI-PROJECT-26860708
  • [Journal Article] A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents.2015

    • Author(s)
      Nan Jia, Yuka Nakazawa, Chaowan Guo, Mayuko Shimada, Mieran Sethi, Yoshito Takahashi, Hiroshi Ueda, Yuji Nagayama, Tomoo Ogi
    • Journal Title

      Nature Protocols

      Volume: 10 Issue: 1 Pages: 12-24

    • DOI

      10.1038/nprot.2014.194

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-14F04093, KAKENHI-PROJECT-24591368, KAKENHI-PROJECT-24659533, KAKENHI-PROJECT-24681008, KAKENHI-PROJECT-24790321, KAKENHI-PROJECT-25870534, KAKENHI-PROJECT-26291005, KAKENHI-PROJECT-26461528, KAKENHI-PROJECT-15K09437
  • [Journal Article] Haploinsufficiency of interferon regulatory factor 4 strongly protects against autoimmune diabetes in non-obese diabetic mice.2015

    • Author(s)
      Akazawa S, Kobayashi K, Kuriya G, Horie I, Yu L, Yamasaki H, Okita M, Nagayama Y, Matsuyama T, Akbari M, Yui K, Kawakami A, Abiru N.
    • Journal Title

      Diabetologia

      Volume: 58 (11) Issue: 11 Pages: 2606-2614

    • DOI

      10.1007/s00125-015-3724-3

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09437, KAKENHI-PROJECT-15H05277, KAKENHI-PROJECT-15K19518, KAKENHI-PROJECT-25293101
  • [Journal Article] Cancer stem cell theory and intratumor heterogeneity in thyroid carcinogenesis.2015

    • Author(s)
      Nakashima M, Shimamura M, Yasui K, Mitsutake N, Matsuu-Matsuyama M, Matsuda K, Nagayama Y.
    • Journal Title

      J Basic Clin Med.

      Volume: 4 (1) Pages: 8-12

    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Journal Article] Cancer stem cell theory and intratumor heterogeneity in thyroid carcinogenesis.2015

    • Author(s)
      Nakashima M, Shimamura M, Yasui K, Mitsutake N, Matsuu-Matsuyama M, Matsuda K, Nagayama Y.
    • Journal Title

      J Basic Clin Med.

      Volume: 4(1) Pages: 8-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Journal Article] XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency.2015

    • Author(s)
      Guo C, Nakazawa Y, Woodbine L, Bjorkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS,Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 136 (4) Issue: 4 Pages: 1007-1017

    • DOI

      10.1016/j.jaci.2015.06.007

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09437, KAKENHI-PROJECT-26461528, KAKENHI-PROJECT-14F04093, KAKENHI-PROJECT-26291005, KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-15H05333
  • [Journal Article] Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAFV600E-induced thyroid tumors in a mouse model.2014

    • Author(s)
      Orim F, Bychkov A, Shimamura M, Nakashima M, Ito M, Matsuse M, Kurashige T, Suzuki K, Saenko V, Nagayama Y, Yamashita S, Mitsutake N
    • Journal Title

      Thyroid

      Volume: 24(3) Issue: 3 Pages: 502-510

    • DOI

      10.1089/thy.2013.0038

    • NAID

      120006986647

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23510064, KAKENHI-PROJECT-23591357, KAKENHI-PROJECT-24591368, KAKENHI-PROJECT-25257508, KAKENHI-PROJECT-25460470, KAKENHI-PROJECT-25861110
  • [Journal Article] Analysis of multiple markers for cancer stem-like cells in human thyroid carcinoma cell lines.2014

    • Author(s)
      Shimamura M, Nagayama Y, Matsuse M, Yamashita S, Mitsutake N.
    • Journal Title

      Endocrine J.

      Volume: 61(15) Pages: 481-490

    • NAID

      130004443968

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Journal Article] Minor contribution of cytotoxic T lymphocyte antigen 4 and programmed cell death 1 ligand 1 in immune tolerance against mouse thyrotropin receptor in mice.2014

    • Author(s)
      Yasui J, Nakahara M, Shimamura M, Kurashige T, Yasui K, Abiru N, Kawakami A, Nagayama Y.
    • Journal Title

      Acta Med Nagasaki.

      Volume: 59(1) Pages: 13-17

    • NAID

      110009959607

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Journal Article] Disruption of transforming growth factor- signaling in thyroid follicular epithelial cells or intrathyroidal fibroblasts does not promote thyroid carcinogenesis.2014

    • Author(s)
      Shimamura M, Nakahara M, Kurashige T, Yasui K, Nakashima M, Nagayama Y.
    • Journal Title

      Endocrine J.

      Volume: 61 (3) Pages: 502-510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Journal Article] Identification of new Cockayne syndrome patients deficient in the ERCC1 and XPF/ERCC4 gene.2013

    • Author(s)
      Kashiyama K, Nakazawa Y, Shimada M, Sasaki K, Takahashi Y, Fawxett H, Lewin SO, Carr L, Yoshida K, Utani A, Hirano A, Yamashita S, Nagayama Y, Mitsutake N, Lehmann AR, Ogi T.
    • Journal Title

      Am J Hum Gnenet

      Volume: なし

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Journal Article] Genetic deletion of Granzyme B does not confer resistance to the development of spontaneous diabetes in NOD mice.2013

    • Author(s)
      Kobayashi M, Kaneko-koike C, Abiru N, Uchida T, Akazawa S, Nakamura K, Kuriya G, Satoh T, Ida H, Kawasaki E, Yamasaki H, Nagayama Y, Sasak H, Kawakami A.
    • Journal Title

      Clin Exp Immunol

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Journal Article] Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma2013

    • Author(s)
      Shimamura M, Nakahara M, Orim F, Kurashige T, Mitsutake N, Nakashima M, Kondo S, Yamada M, Taguchi R, Kimura S, Nagayama Y
    • Journal Title

      Endocrinology

      Volume: 154 Issue: 11 Pages: 4423-30

    • DOI

      10.1210/en.2013-1174

    • NAID

      120006986735

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591357, KAKENHI-PROJECT-24591368, KAKENHI-PROJECT-24790948, KAKENHI-PROJECT-25257508
  • [Journal Article] SNAIL induces epithelial-to-mesenchymal transition and cancer stem cell-like properties in aldehyde dehydroghenase-negative thyroid cancer cells2013

    • Author(s)
      Yasui K, Shimamura M, Mitsutake N, Nagayama Y
    • Journal Title

      Thyroid

      Volume: 23 Issue: 8 Pages: 989-96

    • DOI

      10.1089/thy.2012.0319

    • NAID

      120006986096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591357, KAKENHI-PROJECT-23659478, KAKENHI-PROJECT-24591368, KAKENHI-PROJECT-25257508
  • [Journal Article] Examination of Orbital Tissues in Murine Models of Graves' Disease reveals expression of UCP-1 and the TSHR in retrobulbar adipose tissues.2013

    • Author(s)
      Johnson KTM, Ziler B, Schott M, Müller M, Minich WB, Nagayama Y, Gulbins E, Eckstein AK, Berchner-Pfannschmidt U.
    • Journal Title

      Hor Metb Res

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Journal Article] Double deficiency in IL-17 and IFN-g signaling significantly suppresses the development of diabetes in the NOD mouse.2013

    • Author(s)
      Kuriya G, Abiru N, Kobayashi M, Nagayama Y, Akazawa S, Nakamura K, Sato T, Horie I, Kuwahara H, Kawasaki E, Yamasaki H, Yu L, Eisenbarth GS, Iwakura Y, Eguchi K.
    • Journal Title

      Diabetologia

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Journal Article] Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice.2012

    • Author(s)
      Nagayama Y, Nakahara M, Shimamura M, Horie I, Arima K, Abiru N.
    • Journal Title

      Clin Exp Immunol

      Volume: 168 Issue: 3 Pages: 268-273

    • DOI

      10.1111/j.1365-2249.2012.04578.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791060, KAKENHI-PROJECT-24591334, KAKENHI-PROJECT-24591368, KAKENHI-PROJECT-24790948
  • [Journal Article] Adoptive Transfer of Antithyrotropin Receptor(TSHR) Autoimmunity from TSHR Knockout Mice to Athymic Nude Mice2012

    • Author(s)
      M Nakahara, K Johnson, A Eckstein, R Taguchi, M Yamada, N Abiru, Nagayama Y.
    • Journal Title

      Endocrinology

      Volume: (4) Pages: 2034-42

    • NAID

      120006985412

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591143
  • [Journal Article] Adoptive transfer of antithyrotropin receptor (TSHR) autoimmunity from TSHR knockout mice to athymic nude mice2012

    • Author(s)
      Nakahara M, Johnson K, Eckstein A, Taguchi R, Yamada M, Abiru N, Nagayama Y.
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 4 Pages: 2034-2042

    • DOI

      10.1210/en.2011-1846

    • NAID

      120006985412

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591334, KAKENHI-PROJECT-24591368, KAKENHI-PROJECT-24790948
  • [Journal Article] B cell-targeted therapy with anti-CD20 monoclonal antibody in a mouse model of Graves' hyperthyroidism2011

    • Author(s)
      I Ueki, N Abiru, M Kobayashi, M Nakahara, T Ichikawa, K Eguchi, Y Nagayama
    • Journal Title

      Clin Exp Immunol

      Volume: 163(3) Pages: 309-317

    • NAID

      120006984774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591143
  • [Journal Article] Differential role of T helper type 17 immune response for Graves' hyperthyroidism in mice with distinct genetic backgrounds.2011

    • Author(s)
      Horie I, Abiru N, Saitoh O, Ichikawa T, Iwakura Y, Hguchi K, Nagayama Y.
    • Journal Title

      Autoimmunity

      Volume: 44 Pages: 159-165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse2011

    • Author(s)
      Satoh T, Abiru N, Kobayashi M, Zhou H, Nakamura K, Kuriya G, Nagayama Y, Kawasaki E, Yamasaki H, Yu L, Eisenbarth GS, Araki E, Mori M, Oyadomari S, Eguchi K.
    • Journal Title

      Apoptosis

      Volume: (in press)

    • NAID

      120006984789

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Distinct role of T helper Type 17 immune response for Graves' hyperthyroidism in mice with different genetic backgrounds2011

    • Author(s)
      I Horie, N Abiru, O Saitoh, T Ichikawa, Y Iwakura, K Eguchi, Y Nagayama
    • Journal Title

      Autoimmunity

      Volume: 44(2) Pages: 159-165

    • NAID

      120006984782

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591143
  • [Journal Article] Induction of autoimmune thyroiditis by depletion of CD4+ CD25+ regulatory T cells in thyroiditis-resistant IL-17, but not interferon-gamma receptor, knockout nonobese diabetic-H2h4 mice2011

    • Author(s)
      I Horie, N Abiru, H Sakamoto, Y Iwakura, Y Nagayama
    • Journal Title

      Endocrinology

      Volume: 152(11) Pages: 4448-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591143
  • [Journal Article] B Cell-Targeted Therapy with anti-CD20 monoclonal antibody in a mouse model of Graves' Hyperthyroidism.2011

    • Author(s)
      Ueki I, Abiru N, Kobayashi M, Saitoh O, Ichikawa T, Kerley, Eguchi K, Nagayama Y.
    • Journal Title

      Clin Exp Immunol. 163(3)

      Pages: 309-317

    • NAID

      120006984774

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse2011

    • Author(s)
      T Satoh, N Abiru, N Kobayashi, H Zhou, K Nakamura, G Kuriya, H Nakamura, Y Nagayama, E Kawasaki, H Yamasaki, L Yu, GS Eisenbarth, E Araki, M Mori, S Oyadomari, K Eguchi
    • Journal Title

      Apoptosis

      Volume: 6(4) Pages: 438-48

    • NAID

      120006984789

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591143
  • [Journal Article] The effect of Regulatory T cell depletion on the spectrum of organ-specific autoimmune diseases in non-obese diabetic mice at different ages.2011

    • Author(s)
      Nakahara M, Nagayama Y, Ichikawa T, Liping Yu, George S.Eisenbarth, Abiru N.
    • Journal Title

      Autoimmunity

      Volume: (in press)

    • NAID

      120006985001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Differential role of T helper type 17 immune response for Graves' hyperthyroidism in mice with distinct genetic backgrounds.2011

    • Author(s)
      Horie I, Abiru N, Saitoh O, Ichikawa T, Iwakura Y, Eguchi K, Nagayama Y.
    • Journal Title

      Autoimmunity. 44(2)

      Pages: 159-165

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Current concentration of artificial radionuclides and estimated radiation doses around the Chernobyl Nuclear Power Plant, the Semipalatinsk Nuclear Testing Site, and in Nagasaki.2011

    • Author(s)
      Taira Y, Hayashida N, Brahmanandhan GM, Nagayama Y, Yamashita S, Takahashi J, Gutevitc A, Kozlovsky A, Urazalin M, Takamura N.
    • Journal Title

      J Radiat Res. 52(1)

      Pages: 88-95

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] B Cell-Targeted Therapy with anti-CD20 monoclonal antibody in a mouse model of Graves' Hyperthy roidism.2011

    • Author(s)
      Ueki I, Abiru N, Kobayashi M, Saitoh O, Ichikawa T, Kerley, Eguchi K, Nagayama Y.
    • Journal Title

      Clinical and Experimental Immunology

      Volume: 163 Pages: 309-317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] The effect of regulatory T-cell depletion on the spectrum of organ-specific autoimmune diseases in nonobese diabetic mice at different ages2011

    • Author(s)
      M Nakahara, Y Nagayama, T Ichikawa, L Yu, GS Eisenbarth, N Abiru
    • Journal Title

      Autoimmunity

      Volume: 44(6) Pages: 504-510

    • NAID

      120006985001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591143
  • [Journal Article] Current concentration of artificial radionuclides and estimated radiation doses around the Chernobyl Nuclear Power Plant, the Semipalatinsk Nuclear Testing Site, and in Nagasaki.2011

    • Author(s)
      Taira Y, Hayashida N, Brahmanandhan GM, Nagayama Y, Yamashita S, Takahashi J, Gutevitc A, Kozlovsky A, Urazalin M, Takamura N.
    • Journal Title

      Journal of Radiation Research

      Volume: 52 Pages: 88-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Interleukin 10 deficiency attenuates induction of anti-TSH receptor antibodies and hyperthyroidism in a mouse Graves' model2011

    • Author(s)
      I Ueki, N Abiru, K Kawagoe, Y Nagayama
    • Journal Title

      J Endocrinol

      Volume: 209(3) Pages: 353-357

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591143
  • [Journal Article] Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2^<h4> mice but are not associated with experimentally induced thyroiditis.2010

    • Author(s)
      Chen C-R, Hamidi S, Braley-Mullen H, Nagayama Y, Bresee CMS, Rapoport B, McLachlan SM.
    • Journal Title

      Endocrinology. 151(9)

      Pages: 4583-4593

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Observations on the proposed "nonclassical" model of autoimmune hypothyroidism.2010

    • Author(s)
      Nagayama Y
    • Journal Title

      Thyroid

      Volume: 20 Pages: 665-666

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice but are not associated with experimentally induced thyroiditis.2010

    • Author(s)
      Chen C-R, Hamidi S, Braley-Mullen H, Nagayama Y, Bresee CMS, Rapoport B, McLachlan SM.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 4583-4593

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Enhanced response to mouse thyrotropin (TSH) receptor immunization in TSH knockout mice.2010

    • Author(s)
      Nakahara M, Mitsutake N, Sakamoto H, Ichiakwa T, Abiru N, Chen C-R, Rapoport B, McLachlan SM, Nagayama Y.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 4047-4054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Enhanced response to mouse thyrotropin (TSH) receptor immunization in TSH knockout mice.2010

    • Author(s)
      Nakahara M, Mitsutake N, Sakamoto H, Ichiakwa T, Abiru N, Chen C-R, Rapoport B, McLachlan SM, Nagayama Y.
    • Journal Title

      Endocrinology. 151(8)

      Pages: 4047-4054

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Observations on the proposed "nonclassical" model of autoimmune hypothyroidism.2010

    • Author(s)
      Nagayama Y.
    • Journal Title

      Thyroid. 20(6)

      Pages: 665-666

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Studies in mice deficient for the Autoimmune Regulator(Aire)and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens2009

    • Author(s)
      Misharin A, Aliesky H, Nagayama Y, Rapoport B, McLachlan SM.
    • Journal Title

      Endocrinology 150

      Pages: 2948-2956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Attenuation of induced hyperthyroidism in mice by pre-treatment with thyrotropin receptor protein : diversion of thyroid stimulating antibody to non-functional antibody induction.2009

    • Author(s)
      Misharin AV, Nagayama Y, Holly A.Aliesky AH, Mizutori Y, Rapoport B, McLachlan SM.
    • Journal Title

      Endocrinology 150

      Pages: 3944-3952

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] T helper type 17 immune response plays an indispensable role for development of experimental autoimmune thyroiditis in NOD-H2^<h4> mice.2009

    • Author(s)
      Horie I, Abiru N, Nagayama Y, Saitoh O, Ichikawa T, Iwakura Y, Eguchi K.
    • Journal Title

      Endocrinology. 150(11)

      Pages: 5135-5142

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Expression of immuno-regulatory molecules on the thyrocytes protects NOD-H2^<h4> mice from developing autoimmune thyroiditis2009

    • Author(s)
      Nakahara M, Nagayama Y, Sogawa R, Saitoh O, Tone S, Abiru N.
    • Journal Title

      Endocrinology 150

      Pages: 1545-1551

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Fibroblast- mediated in vivo and in vitro growth promotion of thyroid carcinoma FTRL-Tc, not normal thyroid FRTL5, cells.2009

    • Author(s)
      Saitoh O, Mitsutake N, Nakayama T, Nagayama Y.
    • Journal Title

      Thyroid. 19(7)

      Pages: 735-742

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Fibroblast-mediated in vivo and in vitro growth promotion of thyroid carcinoma FTRL-Tc, not normal thyroid FRTL5, cells.2009

    • Author(s)
      Saitoh O, Mitsutake N, Nakayama T, Nagayama Y.
    • Journal Title

      Thyroid 19

      Pages: 735-742

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Induction of late-onset, spontaneous autoimmune thyroiditis by a single low-dose irradiation in non-obese diabetic-H2^<h4> mice.2009

    • Author(s)
      Nagayama Y, Ichikawa T, Saitoh O, Abiru N.
    • Journal Title

      J Radiat Res. 50(6)

      Pages: 573-577

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Studies in mice deficient for the Autoimmune Regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens.2009

    • Author(s)
      Misharin A, Aliesky H, Nagayama Y, Rapoport B, McLachlan SM.
    • Journal Title

      Endocrinology. 150(6)

      Pages: 2948-2956

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Attenuation of induced hyperthyroidism in mice by pre-treatment with thyrotropin receptor protein : diversion of thyroid stimulating antibody to non-functional antibody induction.2009

    • Author(s)
      Misharin AV, Nagayama Y, Holly A. Aliesky AH, Mizutori Y, Rapoport B, McLachlan SM.
    • Journal Title

      Endocrinology. 150(8)

      Pages: 3944-3952

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] T helper type 17 immune response plays an indispensable role for development of experimental autoimmune thyroiditis in NOD-H2^<h4> mice.2009

    • Author(s)
      Horie I, Abiru N, Nagayama Y, Saitoh O, Ichikawa T, Iwakura Y, Eguchi K.
    • Journal Title

      Endocrinology 150

      Pages: 5135-5142

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Expression of immuno-regulatory molecules on the thyrocytes protects NOD-H2^<h4> mice from developing autoimmune thyroiditis.2009

    • Author(s)
      Nakahara M, Nagayama Y, Sogawa R, Saitoh O, Tone S, Abiru N.
    • Journal Title

      Endocrinology. 150(3)

      Pages: 1545-1551

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Induction of late-onset spontaneous autoimmune thyroiditis by a single low-dose irradiation in thyroiditis-prone non-obese diabetic-H2(h4)mice.2009

    • Author(s)
      Y Nagayama
    • Journal Title

      J Radiat Res(Tokyo) 50

      Pages: 573-577

    • NAID

      10025913203

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591143
  • [Journal Article] Induction of late-onset, spontaneous autoimmune thyroiditis by a single low-dose irradiation in non-obese diabetic-H2^<h4> mice.2009

    • Author(s)
      Nagayama Y, Ichikawa T, Saitoh O, Abiru N.
    • Journal Title

      Journal of Radiation Research 50

      Pages: 573-577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Role of the human A-subunit in transgenic mice that develop thyroid lymphocytic infiltration after immunization and regulatory T cell depletion.2008

    • Author(s)
      Mizutori Y, Nagayama Y, Flower D, Misharin A, Aliesky HA, Rapoport B, McLachlan SM.
    • Journal Title

      Clin Exp Immunol. 154(3)

      Pages: 305-315

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Exacerbation of autoimmune thyroiditis by a singledose of whole body irradiation in NOD-H2^<h4> mice.2008

    • Author(s)
      Nagayama Y, et al.
    • Journal Title

      Int J Radiat Biol. 84

      Pages: 761-769

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Exacerbation of autoimmune thyroiditis by a single dose of whole body irradiation in NOD-H2h4 mice.2008

    • Author(s)
      Nagayama Y, Kaminoda K, Mizutori Y, Saitoh O, Abiru N.
    • Journal Title

      Int J Radiat Biol. 84(9)

      Pages: 761-769

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Combined activation of innate and adaptive immunity with polyinosinic- polycytidylic acid and insulin B:9-23 self-peptide in the genetically susceptible NOD mouse : differential effects on insulitis and diabetes progression.2008

    • Author(s)
      Fukushima K, Kobayashi M, Nagayama Y, Satoh T, Nakahara M, Kawasaki E, Yamasaki H, Ueha S, Matsushima K, Liu E, Eisenbarth GS, Eguchi K, Abiru N.
    • Journal Title

      Biochem Biophys Res Commun. 367(4)

      Pages: 719-724

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Role of the human A-subunit in transgenic mice that develop thyroid lymphocytic infiltration after immunization and regulatory T cell depletion.2008

    • Author(s)
      Mizutori Y, Nagayama Y, et al.
    • Journal Title

      Clin Exp Immunol. 154

      Pages: 305-315

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Combined activation of innate and adaptive immunity with polyinosinic-polycytidylic acid and insulin B : 9-23 self-peptide in the genetically susceptible NOD mouse : differential effects on insulitis and diabetes progression.2008

    • Author(s)
      Fukushima K, Kobayashi M, Nagayama Y, et al.
    • Journal Title

      Biochem Biophys Res Commun. 367

      Pages: 719-724

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cells.2007

    • Author(s)
      Nagayama Y, Hase W, Motoyoshi Y, Saitoh O, Sogawa R, Nakao K.
    • Journal Title

      Oncol Rep. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cells2007

    • Author(s)
      Yuji, Nagayama, Wataru, Hase, Yasuhide, Motoyoshi, Ohki, Saitoh, Rintaroh, Sogawa, Kazuhiko, Nakao
    • Journal Title

      Oncology Reports 17(5)

      Pages: 1269-1273

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590739
  • [Journal Article] Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cells2007

    • Author(s)
      Nagayama Yuji, et. al.
    • Journal Title

      Oncology Repoets 17・5

      Pages: 1269-1273

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590739
  • [Journal Article] Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cells2007

    • Author(s)
      Nagayama Yuji, et. al.
    • Journal Title

      Oncology Reports 17・5

      Pages: 1269-1273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590739
  • [Journal Article] Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cells.2007

    • Author(s)
      Nagayama Y
    • Journal Title

      Oncology Reports (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Regulation of Graves' hyperthyroidism with naturally occurring CD4^+CD25^+ regulatory T cells in a mouse model.2006

    • Author(s)
      Saitoh O, Nagayama Y.
    • Journal Title

      Endocrinology. 147(5)

      Pages: 2417-2422

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Different mechanisms for anti-tumor effects of low- and high-dose cyclophosphamide2006

    • Author(s)
      Yasuhide, Motoyoshi, Kazuhisa, Kaminoda, Ohki, Saitoh, Keisuke, Hamasaki, Kazuhiko, Nakao, Nobuko, Ishii, Yuji, Nagayama, Katsumi, Eguchi
    • Journal Title

      Oncology Reports 16(1)

      Pages: 141-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590739
  • [Journal Article] Different mechanisms for anti-tumor effects of low-and high-dose cyclophosphamide.2006

    • Author(s)
      Motoyoshi Y, Kaminoda K, Saitoh O, Hamasaki K, Nakao K, Ishii N, Nagayama Y, Eguchi K.
    • Journal Title

      Oncol Rep. 16(1)

      Pages: 141-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] BrafV600E promotes invasiveness of thyroid cancer cells through NF-kB activation.2006

    • Author(s)
      Palona I, Namba H, Mitsutake N, Starenki D, Podtchenko A, Sediarou I, Ohtsuru A, Saenko V, Nagayama Y, Umezawa K, Yamashita S.
    • Journal Title

      Endocrinology. 147(12)

      Pages: 5699-5707

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Adenovirus coding the thyrotropin receptor A subunit improves the efficacy of dendritic cell-based mouse model of Graves' hyperthyroidism.2006

    • Author(s)
      Mizutori Y, Saitoh O, Eguchi K, Nagayama Y.
    • Journal Title

      J Autoimmun. 26(1)

      Pages: 32-36

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Animal models of Graves' hyperthyroidism.2005

    • Author(s)
      Nagayama Y.
    • Journal Title

      Endocrine Journal 52(4)

      Pages: 385-394

    • NAID

      130004769937

    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Adenovirus-mediated gene delivery of interleukin-10, but not transforming growth factor beta, ameliorates Graves' hyperthyroidism in BALB/c mice.2005

    • Author(s)
      Saitoh O, Mizutori Y, Takamura N, Kita A, Kuwahara H, Yamasaki H, Nagayama Y.
    • Journal Title

      Clin Exp Immunol. 141(3)

      Pages: 405-411

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Insight into Graves' hyperthyroidism from animal models.2005

    • Author(s)
      McLachlan SM, Nagayama Y, Rapoport B.
    • Journal Title

      Endocr Rev. 26(6)

      Pages: 800-832

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Animal models of Graves' hyperthyroidism.2005

    • Author(s)
      Nagayama Y
    • Journal Title

      Endocrine Journal 52(4)

      Pages: 385-394

    • NAID

      130004769937

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Animal models of Graves' hyperthyroidism.2005

    • Author(s)
      Nagayama Y.
    • Journal Title

      Endocrine J. 52(4)

      Pages: 385-394

    • NAID

      130004769937

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Vaccination with dendritic cells pulsed with apoptotic cells elicits effective antitumor immunity in murine hepatoma models.2005

    • Author(s)
      Hayashi T, Nakao K, Nagayama Y, Saitoh O, Ichikawa T, Ishikawa H, Hamasaki K, Eguchi K, Ishii N.
    • Journal Title

      Int J Oncol. 26(5)

      Pages: 1313-1319

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Animal model of Graves' disease.2005

    • Author(s)
      Nagayama Y.
    • Journal Title

      Acta Medica Nagasakiensia 50(6)

      Pages: 49-53

    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Animal model of Graves' disease.2005

    • Author(s)
      Nagayama Y
    • Journal Title

      Acta Medica Nagasakiensia 50(2)

      Pages: 49-53

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] Animal model of Graves' disease.2005

    • Author(s)
      Nagayama Y.
    • Journal Title

      Acta Med Nagasaki. 50(2)

      Pages: 49-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590965
  • [Journal Article] CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse.

    • Author(s)
      Satoh T, Abiru N, Kobayashi M, Zhou H, Nakamura K, Kuriya G, Nagayama Y, Kawasaki E, Yamasaki H, Yu L, Eisenbarth GS, Araki E, Mori M, Oyadomari S, Eguchi K.
    • Journal Title

      Apoptosis. in press.

    • NAID

      120006984789

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Journal Article] The effect of Regulatory T cell depletion on the spectrum of organ-specific autoimmune diseases in non-obese diabetic mice at different ages.

    • Author(s)
      Nakahara M, Nagayama Y, Ichikawa T, Liping Yu, George S. Eisenbarth, Abiru N.
    • Journal Title

      Autoimmunity. in press.

    • NAID

      120006985001

    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] MIEAP and ATG5 are tumor suppressors in a mouse model of thyroid cancer2022

    • Author(s)
      濵田航一郎, 蔵重智美, 嶋村美加, 荒川博文, 中村康之, 永山雄二
    • Organizer
      第6回放射線災害・医科学研究拠点 国際シンポジウム
    • Data Source
      KAKENHI-PROJECT-20K08888
  • [Presentation] MIEAP, ATG5は甲状腺がんの腫瘍抑制遺伝子である2022

    • Author(s)
      濵田航一郎, 蔵重智美, 嶋村美加, 荒川博文, 中村康之, 永山雄二
    • Organizer
      第65回日本甲状腺学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K08888
  • [Presentation] 甲状腺オンコサイトーマの病態研究-ミトコンドリア品質管理機構と甲状腺腫瘍-2022

    • Author(s)
      永山雄二
    • Organizer
      原爆後障害研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Presentation] 甲状腺オンコサイトーマにおけるmitochondria eating protein (MIEAP)の発現・機能2021

    • Author(s)
      永山雄二、Mussazhanova Zhanna、嶋村美加、中島正洋
    • Organizer
      第5回放射線災害・医科学研究拠点カンファランス
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Presentation] 三宅賞受賞記念講演:甲状腺オンコサイトーマの研究2021

    • Author(s)
      永山雄二
    • Organizer
      第64回日本甲状腺学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Presentation] 甲状腺癌マウスモデル研究2020

    • Author(s)
      永山雄二
    • Organizer
      第32回日本内分泌外科学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Presentation] Autophagy in the thyroid2019

    • Author(s)
      Nagayama Y
    • Organizer
      Asia Oceania Thyroid Association
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Presentation] Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice2019

    • Author(s)
      Yuji Nagayama, Tomomi Kurashige, Mika Shimamura, Mutsumi Matsuyama, Masahiro Nakashima.
    • Organizer
      第3回放射線災害・医科学研究拠点 国際シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K00548
  • [Presentation] Radiation-induced thyroid cancer; comparison Nagasaki/Hiroshima, Chernobyl and Fukushima.2019

    • Author(s)
      Nagayama Y
    • Organizer
      The NASHIM seminar
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09028
  • [Presentation] マウス甲状腺におけるオートファジーの役割2018

    • Author(s)
      蔵重智美、松山睦美、中島正洋、嶋村美加、永山雄二
    • Organizer
      第3回放射線災害・医科学研究拠点カンファランス
    • Data Source
      KAKENHI-PROJECT-16K00548
  • [Presentation] Thyroid cancer in Nagasaki/Hiroshima, Chernobyl and Fukushima.2017

    • Author(s)
      Nagayama Y.
    • Organizer
      The 2nd summit Italy-Japan
    • Place of Presentation
      ロベレート(イタリア)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Presentation] マウスにおいて、BRAFV600Eは単独で肺転移を伴う甲状腺癌を誘発し、PTEN欠失共存で低分化へ向かう2017

    • Author(s)
      永山雄二、嶋村美加、蔵重智美、渋沢信行、山田正信、中島正洋
    • Organizer
      第60回日本甲状腺学会
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Presentation] 放射線と甲状腺癌・最近の知見2017

    • Author(s)
      永山雄二
    • Organizer
      原子爆弾被爆者指定医療機関等医師研究会
    • Place of Presentation
      長崎県農協会館(長崎県長崎市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Presentation] Mouse Models of Sporadic Thyroid Cancer with Lung Metastasis Derived from BRAF-V600E Alone or in Combination with PTEN Loss.2017

    • Author(s)
      Nagayama Y
    • Organizer
      87th annual meeting of American thyroid association.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Presentation] Thyroid cancer stem cells do not exist.2016

    • Author(s)
      Nagayama Y.
    • Organizer
      86th annual meeting of American thyroid association.
    • Place of Presentation
      デンバー(アメリカ)
    • Year and Date
      2016-09-21
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Presentation] TSH受容体の構造と機能-四半世紀の進展2016

    • Author(s)
      永山雄二
    • Organizer
      第58回甲状腺学会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都港区)
    • Year and Date
      2016-11-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Presentation] Animal models of Graves' diseases.2015

    • Author(s)
      Nagayama Y.
    • Organizer
      The 15th International Thyroid Congress
    • Place of Presentation
      フロリダ(米国)
    • Year and Date
      2015-10-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Presentation] バセドウ病研究:マウスモデルで何がわかったか?2015

    • Author(s)
      永山雄二
    • Organizer
      第4回広島甲状腺疾患研究会
    • Place of Presentation
      オリエンタルホテル広島(広島県、広島市)
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Presentation] Comparison of Radiation Disaster Between Nagasaki, Chernobyl and Fukushima.2015

    • Author(s)
      Nagayama Y.
    • Organizer
      NASHIM symposium
    • Place of Presentation
      テグ(韓国)
    • Year and Date
      2015-09-07
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Presentation] 被爆70年間に果たした長崎大原研の役割-総括と展望2015

    • Author(s)
      永山雄二
    • Organizer
      第56回原子爆弾後障害研究会
    • Place of Presentation
      広島国際会議場(広島県、広島市)
    • Year and Date
      2015-06-07
    • Data Source
      KAKENHI-PROJECT-15K09437
  • [Presentation] バセドウ病・バセドウ病眼症のマウスモデル2014

    • Author(s)
      永山雄二
    • Organizer
      第57回日本甲状腺学会
    • Place of Presentation
      ナレッジキャピタルコングレコンベンションセンター(大阪市)
    • Year and Date
      2014-11-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Presentation] 甲状腺細胞における放射線外照射・内照射誘発DNA二重鎖切断と抗酸化剤の効果の検討2014

    • Author(s)
      永山雄二、藏重智美
    • Organizer
      第57回日本放射線影響学会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Year and Date
      2014-10-02
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Presentation] ヒト甲状腺癌幹細胞の同定におけるAldehyde dehydrogenase (ALDH) 解析の意義2013

    • Author(s)
      蔵重智美、嶋村美加、光武範吏、中島正洋、永山雄二
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      札幌市、ロイトン札幌・さっぽろ芸文館
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Presentation] ヒト甲状腺癌における癌幹細胞誘導機序としての上皮間葉移行(口頭発表)2012

    • Author(s)
      安井和明、嶋村美加、光武範吏、永山雄二
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23659478
  • [Presentation] 甲状腺特異的コンディショナるトランスジェニックマウスの腫瘍形成能の検討2012

    • Author(s)
      永山雄二、嶋村美加、光武範吏
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Presentation] Animal models of Graves' diseases.2012

    • Author(s)
      Nagayama Y.
    • Organizer
      Centennial of Hashimoto Disease
    • Place of Presentation
      Fukuoka, Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591368
  • [Presentation] Animal models of Graves' diseases.2010

    • Author(s)
      永山雄二
    • Organizer
      (symposium) International Thyroid Congress
    • Place of Presentation
      Paris, France
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Enhanced response to mouse thyrotropin (TSH) receptor immunization in TSH receptor knockout mice.2010

    • Author(s)
      Nakahara M, Nagayama Y
    • Organizer
      The 14th International Thyroid Congress
    • Place of Presentation
      Paris, France
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] 理想的な甲状腺癌マウスモデルの作製2010

    • Author(s)
      永山雄二
    • Organizer
      第53回日本甲状腺学会
    • Place of Presentation
      長崎
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] マウスバセドウ病モデルにおける免疫反応とトレランス2010

    • Author(s)
      永山雄二
    • Organizer
      第32回京都甲状腺研究会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Immunization of C57BL/6 and BALB/C with adenoviral TSHR289 casuses significant infiltration of orbital tissues with macrophages and T-lymphocytes.2010

    • Author(s)
      Johnson KT, Ziler B, Thanos M, Carpinteiro A, Schmid KW, Minich W, Gulbins E, Nagayama Y, Eckstein AK
    • Organizer
      International Thyroid Congress
    • Place of Presentation
      Paris, France
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Animal models of Graves' diseases.2010

    • Author(s)
      Nagayama Y
    • Organizer
      International Thyroid Congress
    • Place of Presentation
      Paris
    • Year and Date
      2010-09-12
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] マウス甲状腺自己免疫疾患の病態解析-免疫反応とトレランス-2010

    • Author(s)
      永山雄二
    • Organizer
      第8回1型糖尿病研究会
    • Place of Presentation
      長崎
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Human versus Mouse Thyrotropin Receptor as an Autoantigen in a Mouse Model of Graves' Hyperthyroidism.2010

    • Author(s)
      永山雄二
    • Organizer
      International Society of Endocrinology
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Age-dependent Alteration in a Spectrum of Organ-Specific Autoimmune Diseases in Nonobese Diabetic Mice.2009

    • Author(s)
      Nakahara M, Abiru N, Nagayama Y
    • Organizer
      The 91th Meeting of Endocrine Society
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] バセドウ病マウスモデルにおけるT helper 17(Th17)の病態形成への関与の検討2009

    • Author(s)
      植木郁子、阿比留教生、江口勝美、永山雄二
    • Organizer
      日本免疫学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-12-03
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] バセドウ病マウスモデルにおけるB細胞/形質細胞標的治療の基礎研究2009

    • Author(s)
      植木郁子、阿比留教生、古林正和、斉藤巨樹、江口勝美、永山雄二
    • Organizer
      日本甲状腺学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-04
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Recent advances of mouse models of autoimmune disease2009

    • Author(s)
      永山雄二
    • Organizer
      日本甲状腺学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-04
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Loss of IL-17 does not impact on the development of diabetes, but reduces the expression of insulin autoantibodies in NOD mice.2009

    • Author(s)
      Kuriya G, Abiru N, Nagayama Y, Nakamura K, Sato T, Kobayashi M, Kawasaki E, Yamasaki H, Iwakura Y, Eguchi K
    • Organizer
      IDS 10
    • Place of Presentation
      Sweden
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Granzyme B Deficiency Reduces Cyclophosphamide Induced Diabetes, But Not Spontaneous Diabetes in nonobese diabetic (NOD) mice.2009

    • Author(s)
      Kobayashi M, Kaneko C, Abiru N, Kan Nakamura, Kuriya G, Satoh T, Kawasaki E, Yamasaki H, Nagayama Y, Eguchi K
    • Organizer
      IDS 10
    • Place of Presentation
      Sweden
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Introduction of our global COE program titled "Global Strategic Center for Radiation Health Risk Control".2009

    • Author(s)
      永山雄二
    • Organizer
      5^<th> International scientific- practical conference <<ECOLOGY, RADIATION AND HEALTH>>
    • Place of Presentation
      Semipalatinsk, Kazakhstan
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Different Roles of T Helper Type 17 Immune Response in Experimental Graves' Hyperthyroidism Induced in BALB/c and NOD-H2h4 Mice.2009

    • Author(s)
      Horie I, Saitoh O, Abiru N, Nagayama Y
    • Organizer
      The 91th Meeting of Endocrine Society
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] バセドウ病マウスモデルにおけるT helper 17(Th17)の病態形成への関与の検討2009

    • Author(s)
      堀江一郎、斉藤巨樹、阿比留教生、厨源平、江口勝美、永山雄二
    • Organizer
      日本甲状腺学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] NODマウスにおけるエフェクターT細胞の標的臓器及び制御性T細胞への感受性の加齢に伴う変化2009

    • Author(s)
      中原麻美、永山雄二、阿比留教生
    • Organizer
      日本免疫学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Recent Advances in Studies on Mouse Models of Autoimmune Thyroid Disease.2009

    • Author(s)
      永山雄二
    • Organizer
      International Symposium on Molecular Thyroidology
    • Place of Presentation
      Nagoya
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Recent advances of mouse models of autoimmune disease.2009

    • Author(s)
      永山雄二
    • Organizer
      第52回日本甲状腺学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Fibroblast-Mediated Growth Promotion of Thyroid Carcinoma FRTL-Tc Cells.2009

    • Author(s)
      Saitoh O, Mitsutake N, Nagayama Y
    • Organizer
      The 91th Meeting of Endocrine Society
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Mouse models of Graves' disease.2008

    • Author(s)
      永山雄二
    • Organizer
      International Society of Endocrinology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Aire-deficiency modulates induction of TSHR antibodies and hyperthyroidism in a mouse model of Graves' disease.2008

    • Author(s)
      Misharin A, Aliesky H, Nagayama Y, Rapoport B, McLachlan SM
    • Organizer
      The 90th Meeting of Endocrine Society
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Mouse models of Graves' disease2008

    • Author(s)
      Nagayama Y.
    • Organizer
      13^<th> International Congress of Endocrinology
    • Place of Presentation
      Rio de Janeiro, Bz
    • Year and Date
      2008-11-11
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Recent advances in mouse models of Graves' hyperthyroidism (symposium).2008

    • Author(s)
      永山雄二
    • Organizer
      Korean Thyroid Meeting
    • Place of Presentation
      Gwangju, South Korea
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] 自己免疫性甲状腺疾患マウスモデルの開発と最近の新知見2008

    • Author(s)
      永山雄二
    • Organizer
      第24回甲状腺病態生理研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20591099
  • [Presentation] Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cells2007

    • Author(s)
      Yasuhide, Motoyoshi, Yuji, Nagayama, Wataru, Hase, Ohki, Saitoh, Rintaroh, Sogawa, Kazuhiko, Nakao
    • Organizer
      14th Japan-Korea Hepatitis Meetin
    • Place of Presentation
      Fukuoka, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590739
  • 1.  AKITA Sadanori (90315250)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  HIRAO Akiyoshi (90208835)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  KURASHIGE Tomomi (60568955)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 4.  嶋村 美加 (90736406)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 5.  ABIRU Norio (00380981)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 34 results
  • 6.  AKINO Kozo (60284668)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KOBAYASHI Masakazu (00380874)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  SATOH Tsuyoshi (70437896)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  KURIYA Genpei (50457579)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  NAKAMURA Kan (70530426)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  YASUI Kazuaki (30594064)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  NIWA Masami (20136641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SHIGEMATSU Kazuto (20154205)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  FUJII Tohru (60136661)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TANAKA Katsumi (70244069)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SAITOH Ohki (60380961)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 17.  FURUKAWA Mutsuhisa (20039689)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  NAKAO Kazuhiko (00264218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 19.  ICHIKAWA Tatsuki (80346949)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  浜崎 圭輔 (50333521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 21.  MATSUSE Michiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  SAENKO Vladimir
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  ROGOUNOVITCH Tatiana
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  MISHIMA Hiroyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  OGI Tomoo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  TAKA Hikari
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  KAGA Naoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  堀江 一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  中島 正洋
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 30.  山本 一男
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  光武 範吏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 32.  荒川 博文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  GUO Chaowan
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 34.  伊東 正博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  七條 和子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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