Tateyama Michihiro 立山充博

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TATEYAMA Michihiro 立山充博

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Researcher Number	30276472
Other IDs
Affiliation (Current)	2025: 生理学研究所, 分子細胞生理研究領域, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 生理学研究所, 分子細胞生理研究領域, 准教授 2015 – 2019: 生理学研究所, 分子細胞生理研究領域, 准教授 2006 – 2014: 生理学研究所, 分子生理研究系, 准教授 2005: 生理学研究所, 分子生理研究系, 助教授 1996 – 1998: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General physiology / Basic Section 48020:Physiology-related / Biological Sciences Except Principal Investigator General physiology / General physiology
Keywords	Principal Investigator FRET / Gタンパク質共役型受容体 / G蛋白質共役型受容体 / 代謝型グルタミン酸受容体 / 電気生理学 / GPRC / 膜電位依存性 / マルチシグナリング / 細胞内cAMP濃度 / 細胞内Ca^<2+>濃度 … More / 光クロスリンク / 光クロスリンク反応 / THIKチャネル / ゲーティング / K2P / カリウムチャネル / 非天然アミノ酸 / THIK-1 / イオンチャネル / mechanism / Unnatural amino acid / THIK channel / 構造機能連関 / ゲーティング電流記録 / 膜電位固定下蛍光強度計測 / 代謝型プリン受容体P2Y1R / 電位依存性 / 構造変化 / receptor / kinetics / imaging / G protein / GPCR / Gタンパク質 / G蛋白質 / 分子・細胞生理学 / 一分子FRET / 一分子蛍光 … More Except Principal Investigator 心筋 / Signal transduction / Protein / Biomolecule / Neuroscience / Physiology / シグナル伝達 / 蛋白質 / 生体分子 / 神経科学 / 生理学 / beta-subunit / antisence / BAY K 8644 / isoproterenol / phoisphorylation / gating process / single channel / Ca^<2+> channel / Caアゴニスト / Ca培玩薬 / カルシウム / マンガン / アンチセンス / ベータサブユニット / リン酸化 / パッチクランプ / カルシウムチャネル / La^<3+> / 脱分極 / K^+濃度 / 電気的穿孔 / エレクトロポレーション / 不整脈 / ランタン / 過分極 / リゾリン脂質 / 細胞膜 Less

The distal C-tail of THIK channel regulates the channel gatingPrincipal Investigator
- Principal Investigator
  
  Tateyama Michihiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Institute for Physiological Sciences
Analyses of voltage dependent strucutural changes in the metabotropic purinergic receptor P2Y1RPrincipal Investigator
- Principal Investigator
  
  TATEYAMA MICHIHIRO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
Analysis of the voltage dependence of Gq coupled receptorsPrincipal Investigator
- Principal Investigator
  
  MICHIHIRO TATEYAMA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
High time resolution FRET analysis of the activation of G proteinPrincipal Investigator
- Principal Investigator
  
  TATEYAMA Michihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
Quantitative analyses of G protein activation by the single molecule imagingPrincipal Investigator
- Principal Investigator
  
  TATEYAMA Michihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
Molecular identification and functional analysis of a caffeine receptor on the plasma membrane.
- Principal Investigator
  
  KUBO Yoshihiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
代謝型グルタミン酸受容体C末端領域によるシグナル伝達制御機構の解明Principal Investigator
- Principal Investigator
  
  立山充博
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
代謝型受容体活性化機構の一分子FRETによる可視化Principal Investigator
- Principal Investigator
  
  立山充博
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  National Institute for Physiological Sciences
心筋における電気的膜穿孔による電流誘発に関する研究
- Principal Investigator
  
  OCHI Rikuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Juntendo University
Study on mechanism of modulation of cardiac L-type Ca^<2+> channel by phosphorylation and Ca^<2+>
- Principal Investigator
  
  OCHI Rikuo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Juntendo Universitv School of Medicine

[Book] Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition, Structural rearrangement and functional relation of the metabotropic glutamate receptor2009
- Author(s)
  Kubo Y., Tateyama M
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors2023
- Author(s)
  Tateyama M. and Kubo Y
- Journal Title
  
  PLOS　ONE
  
  Volume: 18 Issue: 4 Pages: e0284962-e0284962
- DOI
  10.1371/journal.pone.0284962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06793, KAKENHI-PROJECT-23K27358
[Journal Article] Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV12023
- Author(s)
  Shogo Hori, Michihiro Tateyama, Tsuyoshi Shirai, Yoshihiro Kubo, Osamu Saitoh
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 2415-2415
- DOI
  10.1038/s41467-023-38051-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06324, KAKENHI-PROJECT-21K06793, KAKENHI-PROJECT-23K21721, KAKENHI-PROJECT-23K27358
[Journal Article] Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 32021
- Author(s)
  Hirazawa Kiichi、Tateyama Michihiro、Kubo Yoshihiro、Shimomura Takushi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 6 Pages: 101425-101425
- DOI
  10.1016/j.jbc.2021.101425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05449, KAKENHI-PROJECT-20H03424, KAKENHI-PROJECT-20K07284, KAKENHI-PROJECT-21K06793
[Journal Article] A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence2020
- Author(s)
  Shimomura Takushi、Yonekawa Yoshiki、Nagura Hitoshi、Tateyama Michihiro、Fujiyoshi Yoshinori、Irie Katsumasa
- Journal Title
  
  eLife
  
  Volume: 9 Pages: 1-21
- DOI
  10.7554/elife.52828
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-17K17795
[Journal Article] Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels.2019
- Author(s)
  Chen IS, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y
- Journal Title
  
  Br J Pharmacol
  
  Volume: 176 Issue: 17 Pages: 3161-3179
- DOI
  10.1111/bph.14717
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-18K15020
[Journal Article] Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A72019
- Author(s)
  Ishii Jun、Suzuki Atsushi、Kimura Toru、Tateyama Michihiro、Tanaka Tatsushi、Yazawa Takuya、Arimasu Yu、Chen I-Shan、Aoyama Kohei、Kubo Yoshihiro、Saitoh Shinji、Mizuno Haruo、Kamma Hiroshi
- Journal Title
  
  Communications Biology
  
  Volume: 2 Issue: 1 Pages: 1-11
- DOI
  10.1038/s42003-019-0503-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15723, KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-17K08557
[Journal Article] Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.2018
- Author(s)
  Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y.
- Journal Title
  
  Cell Rep.
  
  Volume: 22 Issue: 3 Pages: 706-721
- DOI
  10.1016/j.celrep.2017.11.102
- NAID
  120007001417
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09442, KAKENHI-PROJECT-17K00933, KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-15K09405, KAKENHI-PROJECT-16K13030, KAKENHI-PROJECT-15K16217, KAKENHI-PROJECT-16K19549, KAKENHI-PROJECT-18K19551, KAKENHI-PROJECT-16H02684, KAKENHI-PROJECT-16H05333, KAKENHI-PROJECT-17H04203, KAKENHI-PROJECT-17K09839, KAKENHI-PROJECT-20K20392, KAKENHI-PROJECT-17H05059
[Journal Article] Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain.2018
- Author(s)
  Kume S, Shimomura T, Tateyama M, Kubo Y
- Journal Title
  
  Journal of Physioloby
  
  Volume: 596 Issue: 19 Pages: 4629-4650
- DOI
  10.1113/jp276208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-17H04021
[Journal Article] SLO potassium channels antagonize premature decision making in C. elegans2018
- Author(s)
  Aoki I, Tateyama M, Shimomura T, Ihara K, Kubo Y, Nakano S, Mori I.
- Journal Title
  
  Commun Biol.
  
  Volume: 1 Issue: 1 Pages: 123-123
- DOI
  10.1038/s42003-018-0124-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07267, KAKENHI-PROJECT-17K07499, KAKENHI-PROJECT-17K08557, KAKENHI-PUBLICLY-18H04693, KAKENHI-PUBLICLY-18H05123, KAKENHI-WRAPUP-18H05199, KAKENHI-PROJECT-16H02516, KAKENHI-PROJECT-17H04021
[Journal Article] Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation.2018
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 9 Pages: e0204447-e0204447
- DOI
  10.1371/journal.pone.0204447
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-17H04021
[Journal Article] Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ-independent manner and an amino acid residue at the slide helix governs the activation.2017
- Author(s)
  Chen, I.S., Tateyama, M., Fukata, Y., Uesugi, M., & Kubo, Y.
- Journal Title
  
  Journal of Physiology
  
  Volume: 595 Issue: 17 Pages: 5895-5912
- DOI
  10.1113/jp274871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-15H04279, KAKENHI-PROJECT-17H04021, KAKENHI-PROJECT-16K18999
[Journal Article] Stabilizing effects of G protein on the active conformation of adenosine A1 receptor differ depending on G protein type2016
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 788 Pages: 122-131
- DOI
  10.1016/j.ejphar.2016.06.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293044, KAKENHI-PROJECT-26460307
[Journal Article] Auto-oxidation products of epigallo-catechin gallate activate TRPA1 and TRPV1 in sensory neurons.2015
- Author(s)
  Kurogi, M., Kawai, Y., Nagatomo, K., Tateyama, M., Kubo, Y. and Saitoh, O.
- Journal Title
  
  Chemical Senses
  
  Volume: 40(1) Issue: 1 Pages: 27-46
- DOI
  10.1093/chemse/bju057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J10322, KAKENHI-PROJECT-24570170, KAKENHI-PROJECT-24700307, KAKENHI-PROJECT-26460307, KAKENHI-PROJECT-26860143
[Journal Article] FRET analysis of the activation of GPCR2014
- Author(s)
  立山充博、久保義弘
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 143 Issue: 5 Pages: 249-253
- DOI
  10.1254/fpj.143.249
- NAID
  130004827697
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-26460307
[Journal Article] Analyses of the effects of Gq protein on the activated states of the muscarinic M3 receptor and the purinergic P2Y1 receptor2013
- Author(s)
  Tateyama M and Kubo Y
- Journal Title
  
  Physiological Reports
  
  Volume: 1(5) Issue: 5
- DOI
  10.1002/phy2.134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390045, KAKENHI-PROJECT-23590270
[Journal Article] Binding of Gq protein stabilizes the activated state of the muscarinic receptor type 12013
- Author(s)
  Tateyama, M., Kubo, Y
- Journal Title
  
  Neuropharmacol.
  
  Volume: 65 Pages: 173-183
- DOI
  10.1016/j.neuropharm.2012.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590270
[Journal Article] GABA_B受容体の構造と機能2012
- Author(s)
  立山充博, 松下真一, 久保義弘
- Journal Title
  
  臨床神経科学(中外医学社)
  
  Volume: 30巻第12号 Pages: 1349-1351
- Data Source
  KAKENHI-PROJECT-23590270
[Journal Article] GABAB受容体の構造と機能2012
- Author(s)
  立山充博、松下真一、久保義弘
- Journal Title
  
  臨床神経科学
  
  Volume: 30 Pages: 1349-1351
- Data Source
  KAKENHI-PROJECT-23590270
[Journal Article] The intra-molecular activation mechanisms of the dimeric metabotropic glutamate receptor 1 differ depending on the type of G proteins2011
- Author(s)
  Tateyama, M., Kubo, Y
- Journal Title
  
  Neuropharmacol.
  
  Volume: 61 Issue: 4 Pages: 832-841
- DOI
  10.1016/j.neuropharm.2011.05.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590270
[Journal Article] G蛋白質共役型受容体の構造変化の全反射照明下FRET法による解析2010
- Author(s)
  久保義弘、立山充博
- Journal Title
  
  医学の歩み最新G蛋白質共役受容体研究
  
  Volume: 233 Pages: 699-703
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] G蛋白質共役型受容体の構造変化の全反射照明下FRET法による解析2010
- Author(s)
  久保義弘、立山充博
- Journal Title
  
  医学の歩み(医歯薬出版株式会社) 233巻第9号
  
  Pages: 699-703
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Ligand-induced rearrangements of the GABAB receptor revealed by fluorescence resonance energy transfer.2010
- Author(s)
  Matsushita S., Nakata H., Kubo Y., Tateyama M.
- Journal Title
  
  J.Biol.Chem. 285
  
  Pages: 10291-10299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Ligand-induced rearrangements of the GABAB receptor revealed by fluorescence resonance energy transfer2010
- Author(s)
  Matsushita, S., Nakata, H.Kubo, Y., Tateyama, M.
- Journal Title
  
  Journal of Biological Chemistry 285
  
  Pages: 10291-10299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer.2009
- Author(s)
  Gleitsman KR, Tateyama M., Kubo Y.
- Journal Title
  
  Am.J.Physiol.Cell Physiol. 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article]2009
- Author(s)
  Kubo, Y., Tateyama M
- Journal Title
  
  Structural rearrangement and functional relation of the metabotropic glutamate receptor. in Handbook of Neurochemistry and Molecular Neurobiology.3rd Edition(Springer)
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Regulatory role of C-terminus in the G protein coupling of the metabotropic glutamate receptor 1.2008
- Author(s)
  立山充博, 久保義弘
- Journal Title
  
  J.Neurochem. 107
  
  Pages: 1036-1046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Regulatory role of C-terminus in the G protein coupling of the metabotropic glutamate receptor 12008
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Journal of Neurochemistry 107
  
  Pages: 1036-1046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Journal Article] Coupling profile of the metabotropic glutamate receptor 1□ is regulated by the C-terminal domain.2007
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Molecular and Cellular Neuroscience 34
  
  Pages: 445-452
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Coupling profile of the metabotropic glutamate receptor 1α is regulated by the C-terminal domain2007
- Author(s)
  Tateyama M and Kubo Y
- Journal Title
  
  Molecular and Cellular Neuroscience 34
  
  Pages: 445-452
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Coupling profile of the metabotropic glutamate receptor 1□is regulated by the C-terminal domain.2007
- Author(s)
  Tateyama M, Kubo Y
- Journal Title
  
  Molecular and Cellular Neuroscience 34
  
  Pages: 445-452
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390067
[Journal Article] Coupling profile of the metabotropic glutamate receptor 1α is regulated by the C-terminal domain.2007
- Author(s)
  Tateyama, M., Kubo, Y
- Journal Title
  
  Mol. Cell. Neurosci. 34
  
  Pages: 445-442
- Data Source
  KAKENHI-PROJECT-17689010
[Journal Article] Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1α2006
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 103・4
  
  Pages: 1124-1128
- Data Source
  KAKENHI-PROJECT-17023047
[Journal Article] A carboxy terminal hydrophobic interface is critical to sodium channel function : relevance to inherited disorders.2006
- Author(s)
  Glaaser IW, Bankston JR, Liu H, Tateyama M, Kass RS
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 24015-24023
- Data Source
  KAKENHI-PROJECT-17689010
[Journal Article] Sustained β-adrenergic stimulation increased L-type Ca^<2+> channel expression in cultured quiescent ventricular myocytes.2006
- Author(s)
  Tateyama-Akuzawa, M., Tateyama, M., Ochi, R.
- Journal Title
  
  J. Physiol. Sci. 56
  
  Pages: 165-172
- NAID
  10019283392
- Data Source
  KAKENHI-PROJECT-17689010
[Journal Article] Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1α2006
- Author(s)
  Tateyama, M., Kubo, Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 103・4
  
  Pages: 1124-1128
- Data Source
  KAKENHI-PROJECT-17689010
[Journal Article] The intra-molecular activation mechanisms of the dimeric metabotropic glutamate receptor 1 differ depending on the type of G proteins.
- Author(s)
  立山充博, 久保義弘
- Journal Title
  
  Neuropharmacol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] 遠位C末端領域によるTHIK-1チャネルの活性制御2023
- Author(s)
  立山充博、久保義弘
- Organizer
  第１０１回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K06793
[Presentation] THIK-１チャネル活性化における膜貫通部位の役割2023
- Author(s)
  立山充博、久保義弘
- Organizer
  日本生理学会100回記念大会
- Data Source
  KAKENHI-PROJECT-21K06793
[Presentation] The 4th transmembrane domain of THIK-1 channel plays critical roles in the regulation of the channel activity2022
- Author(s)
  Michihiro Tateyama, Yoshihiro Kubo
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K06793
[Presentation] Gi/oおよびGq共役型受容体によるTHIK-2チャネルの活性化2020
- Author(s)
  立山充博、久保義弘
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K08557
[Presentation] Metabotropic glutamate receptor mGlu2 regulates signaling via Gq-coupled serotonergic receptor2019
- Author(s)
  Tateyama M, Kubo Y
- Organizer
  FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08557
[Presentation] 代謝型グルタミン酸受容体mGlu2とGq共役型モノアミン受容体の機能的相互作用2018
- Author(s)
  立山充博、久保義弘
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K08557
[Presentation] FRET analyses of voltage dependence of P2Y1R2017
- Author(s)
  立山充博、久保義弘
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松（静岡県浜松市）
- Data Source
  KAKENHI-PROJECT-26460307
[Presentation] Regulation of KCNK13 channel by Gi/o or Gq coupled receptors2016
- Author(s)
  立山充博、久保義弘
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  北海道・札幌市・札幌コンベンションセンタ－
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-26460307
[Presentation] Analyses of the voltage dependence and its structural determinant of the P2Y1 purinergic receptor.2016
- Author(s)
  王培冰、立山充博、久保義弘
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  北海道・札幌市・札幌コンベンションセンタ－
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-26460307
[Presentation] The Gi/o coupled muscarinic receptors form complex with the G protein gated inwardly rectifying potassium channel.2015
- Author(s)
  Tateyama M、Kubo Y
- Organizer
  8th FAOPS
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2015-11-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460307
[Presentation] The KCNK13 channel current is increased by the activation of either the Gi/o- or the Gq-coupled receptor.2015
- Author(s)
  松原美紀、立山充博、久保義弘
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PROJECT-26460307
[Presentation] The Gi/o coupled muscarinic receptors form signaling complex　with the G protein dependent inwardly rectifying potassium channe2015
- Author(s)
  立山充博、久保義弘
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PROJECT-26460307
[Presentation] The Gi/o coupled muscarinic receptors form complex with the G protein gated inwardly rectifying potassium channel for the efficient channel activation.2015
- Author(s)
  立山充博、久保義弘
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  兵庫県・神戸市・神戸国際展示場
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26460307
[Presentation] Activation efficiency of the G protein gated inwardly rectifying potassium channel depends on distance from the Gq but not Gi/o coupled receptors2014
- Author(s)
  立山充博、久保義弘
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26460307
[Presentation] FRETによる受容体活性化過程の可視化2012
- Author(s)
  立山充博、久保義弘
- Organizer
  第132回日本薬学会(招待講演)
- Place of Presentation
  北海道大学・高等教育推進機構（北海道）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] FRET analysis of G protein coupled receptors2012
- Author(s)
  立山充博, 松下真一, 久保義弘
- Organizer
  シンポジウム「イメージングより明らかにされたGタンパク質共役型受容体のダイナミクス」第134回日本薬学会年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] ホモ2量体代謝型グルタミン酸受容体1型の分子内活性化機構は、結合するGタンパク質の種類によって異なる2011
- Author(s)
  立山充博、久保義弘
- Organizer
  第84回日本生化学会大会(招待講演)
- Place of Presentation
  国立京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] m1ムスカリン受容体とGqタンパク質会合のFRET解析2011
- Author(s)
  立山充博、久保義弘
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] Ligand-induced structural rearrangements of G protein coupled receptors revealed by FRET analysis2011
- Author(s)
  立山充博、松下真一、久保義弘
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] Ligand-induced structural rearrangements of G protein coupled receptors revealed by FRET analysis2011
- Author(s)
  立山充博、松下真一、久保義弘
- Organizer
  第87回日本薬理学会大会
- Place of Presentation
  パシフィコ横浜(神奈川県)(大会は中止、紙面発表)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] The intra-molecular activation mechanisms of the dimeric metabo- tropic glutamate receptor1 differ depending on the type of the coupled G-protein2011
- Author(s)
  立山充博, 久保義弘
- Organizer
  シンポジウム「GPCRシグナル伝達の構造と機能:創薬への新たな展開」第84回日本生化学大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] FRET analysis revealed difference in the Gq coupling between m1 muscarinic receptor and metabotropic glutamate receptor12010
- Author(s)
  立山充博、久保義弘
- Organizer
  第33回日本神経科学会大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] Inter-subunit interaction regulates the multiple signaling of metabotropic glutamate receptor 1a2010
- Author(s)
  立山充博、久保義弘
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡市民文化ホール(岩手)
- Year and Date
  2010-05-11
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] Inetersubunit activation of metabotropic glutamate receptor 1a triggers Gq coupled signaling pathway, but not Gi/o one2009
- Author(s)
  立山充博、久保義弘
- Organizer
  第36回国際生理学会大会
- Place of Presentation
  京都国際会議場(京都府)
- Year and Date
  2009-07-31
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] 代謝型グルタミン酸受容体の多様なシグナリングの調節機構シンポジウム「グルタミン酸受容体の新側面」2009
- Author(s)
  立山充博、久保義弘
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] 代謝型グルタミン酸受容体2量体間の Trans 型活性化はGq応答を起こすがGi/o応答は起こさない2009
- Author(s)
  立山充博, 久保義弘
- Organizer
  日本薬理学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] 代謝型グルタミン酸受容体の多様なシグナリングの調節機構2009
- Author(s)
  立山充博、久保義弘
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] PKA依存性リン酸化による代謝型グルタミン酸受容体I型の機能修飾2008
- Author(s)
  立山充博, 久保義弘
- Organizer
  日本神経科学学会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20590224
[Presentation] FRET analyses of the stabilizing effect of Gi1 protein on the agonist-induced activated conformation of the A1aR
- Author(s)
  立山充博、久保義弘
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  国際会議場（京都府）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] 受容体活性化状態に対するGqタンパク質の作用は受容体ごとに
- Author(s)
  立山充博、久保義弘
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] Stabilizing effects of G protein on the active conformation of the adenosine receptor type 1a differ depending on the type of G protein
- Author(s)
  立山充博、久保義弘
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県）
- Data Source
  KAKENHI-PROJECT-23590270
[Presentation] Gqタンパク質はM1RおよびM3Rの活性型構造に対し安定化作用を示すがP2Y1Rでは安定化作用を示さない
- Author(s)
  立山充博、久保義弘
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-23590270

1. KUBO Yoshihiro (80211887)

# of Collaborated Projects: 3 results

# of Collaborated Products: 38 results
2. OCHI Rikuo (10049025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NAKAJO Koichi (80390699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MASUMIYA Haruko (30286744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAITOH Osamu (60241262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 下村拓史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中田正範

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 井原邦夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 青山幸平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 藤吉好則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 入江克雅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tateyama Michihiro 立山 充博

TATEYAMA Michihiro 立山 充博

Research Projects

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Co-Researchers

The distal C-tail of THIK channel regulates the channel gatingPrincipal Investigator

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Analyses of voltage dependent strucutural changes in the metabotropic purinergic receptor P2Y1RPrincipal Investigator

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Analysis of the voltage dependence of Gq coupled receptorsPrincipal Investigator

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High time resolution FRET analysis of the activation of G proteinPrincipal Investigator

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Quantitative analyses of G protein activation by the single molecule imagingPrincipal Investigator

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Molecular identification and functional analysis of a caffeine receptor on the plasma membrane.

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代謝型グルタミン酸受容体C末端領域によるシグナル伝達制御機構の解明Principal Investigator

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代謝型受容体活性化機構の一分子FRETによる可視化Principal Investigator

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心筋における電気的膜穿孔による電流誘発に関する研究

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Study on mechanism of modulation of cardiac L-type Ca^<2+> channel by phosphorylation and Ca^<2+>

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[Book] Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition, Structural rearrangement and functional relation of the metabotropic glutamate receptor2009

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[Journal Article] Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors2023

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[Journal Article] Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV12023

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[Journal Article] Phosphoinositide regulates dynamic movement of the S4 voltage sensor in the second repeat in two-pore channel 32021

Tateyama Michihiro 立山充博

TATEYAMA Michihiro 立山充博