Nobe Koji 野部浩司

… Alternative Names

野部浩司ノベコウジ

NOBE KOJI 野部浩司

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Researcher Number	30276612
Other IDs
External Links
Affiliation (Current)	2025: 昭和大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 昭和大学, 薬学部, 教授 2015 – 2018: 昭和大学, 薬学部, 教授 2012 – 2014: 城西大学, 薬学部, 准教授 2009 – 2011: Showa University, 薬学部, 助教 2002 – 2004: 昭和大学, 薬学部, 助手 1996: 昭和大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology / Biological pharmacy / 応用薬理学・医療系薬学 Except Principal Investigator Basic Section 53040:Nephrology-related / Basic Section 48020:Physiology-related / Applied health science / Applied health science
Keywords	Principal Investigator 糖尿病 / インスリン / 血管平滑筋 / アドレナリン受容体 / 血圧 / rho A / 血管内皮細胞 / 高血圧症 / 収縮反応 / 微小血管 … More / 末梢抵抗血管 / 収縮 / 腎動脈 / 血管 / 腎症 / 高血糖 / 腎血管障害 / 微小血管障害 / 糖尿病性腎症 / 合併症 / 創傷治 / 非筋収縮 / コラーゲン / 線維芽細胞 / 創傷治癒 / 平滑筋 / 細胞内情報伝達系 / プロテインキナーゼC / ジアシルグリセロール … More Except Principal Investigator DHA / EPA / n-3系多価不飽和脂肪酸 / 血管内皮細胞 / 糖尿病合併症 / 脂肪酸 / エイコサペンタエン酸 / 血管内皮機能 / 抗酸化作用 / 抗炎症作用 / SMTPs / 糖尿病性腎症 / KOマウス / 骨格筋 / 心臓 / 骨格筋細胞 / 心筋細胞 / CHP3 / 血管内皮機能障害 / 低酸素トレーニング / n-3系多可不飽和脂肪酸 / 糖尿病 / パルミトオレイン酸 / 一酸化窒素 / ２型糖尿病 / 血管弛緩反応 / 血管収縮反応 Less

真菌由来天然物を用いた糖尿病性腎症の新たな治療戦略の構築
- Principal Investigator
  
  柴田佳太
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Showa University
Role of CHP3 in heart failure induced by diabetes
- Principal Investigator
  
  Kobayashi Soushi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Showa University
The investigations of the effects of fatty acids consumption or direct administration on the functions of cardiovascular system.
- Principal Investigator
  
  Keizo Kasono
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Josai University
Mechanisms of insulin treatment-induced hypertension in diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  Nobe Koji
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Showa University
  Josai University
The investigations of the effects of fatty acids administration on the functions of aorta
- Principal Investigator
  
  KASONO KEIZO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Josai University
Studies of micro-vascular dysfunctions in diabetic complications.Principal Investigator
- Principal Investigator
  
  NOBE KOJI
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Josai University
  Showa University
創傷治癒における線維芽細胞収縮機構の解明〜三次元培養細胞モデルを用いた新しいアプローチによる検討〜Principal Investigator
- Principal Investigator
  
  野部浩司
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
ジアシルグリセロールキナーゼ活性化の解析およびその糖尿病への関与に関する研究Principal Investigator
- Principal Investigator
  
  野部浩司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University

All 2024 2023 2022 2016 2014 2013 2012 2010 2003 2002

All Journal Article Presentation

[Journal Article] Potent Efficacy of 3-Amino-4-hydroxy Benzoic Acid, a Small Molecule Having Anti-fibrotic Activity, in a Mouse Model of Non-alcoholic Steatohepatitis2024
- Author(s)
  Yamaguchi Tomoaki、Shibata Keita、Hasumi Keiji、Nobe Koji
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 2 Pages: 434-442
- DOI
  10.1248/bpb.b23-00771
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-02-16
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08318, KAKENHI-PROJECT-22K20897
[Journal Article] Therapeutic effects of the alkaline extract of leaves of Sasa sp. and elucidation of its mechanism in acute kidney injury2024
- Author(s)
  Sano Mizuki、Koseki Yutaro、Shibata Keita、Fujisawa Tomohiro、Nobe Koji
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 154 Issue: 3 Pages: 148-156
- DOI
  10.1016/j.jphs.2024.01.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08318
[Journal Article] SMTP-44D inhibits atherosclerotic plaque formation in apolipoprotein-E null mice partly by suppressing the AGEs-RAGE axis.2023
- Author(s)
  Terasaki, M., Shibata, K., Mori, Y., Saito, T., Matsui, T., Ohara, M., Fukui, T., Hasumi, K., Higashimoto, Y., Nobe, K., Yamagishi, S.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 24 Issue: 7 Pages: 6505-6518
- DOI
  10.3390/ijms24076505
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06136, KAKENHI-PROJECT-22K08318, KAKENHI-PROJECT-20K06475, KAKENHI-PROJECT-20K07075, KAKENHI-PROJECT-23K07732
[Journal Article] Effect of SMTP-7 on Cisplatin-Induced Nephrotoxicity in Mice2022
- Author(s)
  Hashimoto Terumasa、Shibata Keita、Hasumi Keiji、Honda Kazuo、Nobe Koji
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 12 Pages: 1832-1838
- DOI
  10.1248/bpb.b22-00620
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-12-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-22K08318
[Journal Article] SMTP-44D Exerts Antioxidant and Anti-Inflammatory Effects through Its Soluble Epoxide Hydrolase Inhibitory Action in Immortalized Mouse Schwann Cells upon High Glucose Treatment2022
- Author(s)
  Shinouchi Ryosuke、Shibata Keita、Jono Shiori、Hasumi Keiji、Nobe Koji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 9 Pages: 5187-5187
- DOI
  10.3390/ijms23095187
- Data Source
  KAKENHI-PROJECT-22K08318
[Journal Article] Effects of Fish Oil Supplement on Normobaric Hypoxic Training of the University Male Ekiden Runners2016
- Author(s)
  櫛部静二、小林　悟、竹之内康広、金　賢珠、新井尚之、野部浩司、大竹一男、白幡　晶、加園恵三
- Journal Title
  
  Journal of Lipid Nutrition
  
  Volume: 25 Issue: 1 Pages: 61-74
- DOI
  10.4010/jln.25.61
- NAID
  130005151388
- ISSN
  1343-4594, 1883-2237
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26350904
[Journal Article] 大学男子駅伝選手の常圧下低酸素環境を利用したトレーニングにおける魚油製剤摂取の効果2016
- Author(s)
  櫛部清二、小林悟、竹之内康広、金賢珠、新井尚之、野部浩司、大竹一男、白幡晶、加園恵三
- Journal Title
  
  脂質栄養学
  
  Volume: 25 Pages: 61-74
- NAID
  130005151388
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460346
[Journal Article] Two types of overcontraction are involved in intrarenal artery dysfunction in type II diabetic mouse.2014
- Author(s)
  Nobe K, Takenouchi Y, Kasono K, Hashimoto T, Honda K.
- Journal Title
  
  Journal of Pharmacology and Experimental Theruputics
  
  Volume: 351(1) Issue: 1 Pages: 77-89
- DOI
  10.1124/jpet.114.216747
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460346
[Journal Article] Adiponectin enhances calcium-dependency of mouse bladder contraction mediated by protein kinase Cα expression2013
- Author(s)
  Koji Nobe, Akiko Fujii, Kiyomi Saito, Takaharu Negoro, Yasuo Ogawa, Yasuko Nakano, Terumasa Hashimoto, Kazuo Honda
- Journal Title
  
  J. Pharmacol. Exp. Ther
  
  Volume: 345 Pages: 62-68
- Data Source
  KAKENHI-PROJECT-23500851
[Journal Article] Association between diabetes-related factors and vascular smooth muscle function in diabetic complications2013
- Author(s)
  Nobe K
- Journal Title
  
  Showa Univ. J. Pharmaceutical. Sci
  
  Volume: 3 Pages: 115-128
- NAID
  120006710988
- Data Source
  KAKENHI-PROJECT-21590290
[Journal Article] 糖尿病合併症において血管平滑筋細胞機能に影響する因子2013
- Author(s)
  野部浩司
- Journal Title
  
  昭和大学薬学雑誌
  
  Volume: 3 Pages: 115-128
- NAID
  120006710988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590290
[Journal Article] Spatiotemporal dynamics of intracellular calcium in the middle cerebral artery isolated from stroke-prone spontaneously hypertensive rats2012
- Author(s)
  Terumasa Hashimoto, Mariko Kiya, Hisayuki Ohata, Takuro Miyazaki, Keita Shibata, Koji Nobe and Kazuo Honda
- Journal Title
  
  Exp. Physiol
  
  Volume: 97(2) Pages: 265-276
- Data Source
  KAKENHI-PROJECT-23500851
[Journal Article] Two distinct dysfunctions in diabetic mouse mesenteric artery contraction are caused by changes in the Rho A-Rho kinase signaling pathway2012
- Author(s)
  Koji Nobe, Terumasa Hashimoto and Kazuo Honda
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: 683(1-3) Pages: 217-225
- Data Source
  KAKENHI-PROJECT-23500851
[Journal Article] Two distinct dysfunctions in diabetic mouse mesenteric artery contraction are caused by changes in the Rho-Rho kinase pathway2012
- Author(s)
  Nobe K, Hashimoto T, Honda K
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: 683 Pages: 217-225
- Data Source
  KAKENHI-PROJECT-21590290
[Journal Article] Two distinct dysfunctions in diabetic mouse mesenteric artery contraction are caused by changes in the Rho A-Rho kinase signaling2012
- Author(s)
  Koji Nobe, Terumasa Hashimoto, Kazuo Honda
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590290
[Journal Article] Rho kinase mediates serum-induced contraction in fibroblast fibers independent of myosin LC_<20> phosphorylation.2003
- Author(s)
  Nobe, et al.
- Journal Title
  
  American Journal of Physiology 284
- Data Source
  KAKENHI-PROJECT-14771293
[Journal Article] Fibroblast fiber contraction : Role of C-and Rho kinase activation by thromboxane2003
- Author(s)
  Nobe, et al.
- Journal Title
  
  American Journal of Physiology 285
- Data Source
  KAKENHI-PROJECT-14771293
[Journal Article] 線維芽細胞による収縮反応:非筋細胞収縮の解明とその応用2002
- Author(s)
  野部浩司
- Journal Title
  
  ファルマシア 38
  
  Pages: 784-785
- Data Source
  KAKENHI-PROJECT-14771293
[Presentation] 糖尿病神経障害モデルマウスに対する SMTP-44D の抗酸化作用および抗炎症作用メカニズム～sEH および RAGE との相互作用の検討～2024
- Author(s)
  長塚大樹, 篠内良介, 柴田佳太, 蓮見惠司, 野部浩司
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] NAFLD/NASHによる炎症性サイトカイン非依存的シトクロムP450遺伝子発現低下2024
- Author(s)
  芦野隆, 千葉莉沙子, 村田百奈美, 柴田佳太, 野部浩司, 岩倉洋一郎, 沼澤聡
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] メカニカルストレス付与による化学療法誘発性末梢神経障害モデルマウスにおけるオキシトシン発現の解析2023
- Author(s)
  渡辺佳愛子, 篠内良介, 佐々木晶子, 柴田佳太, 古林創史, 芦野隆, 辻まゆみ, 木内祐二, 野部浩司
- Organizer
  第149回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] クマザサアルカリ抽出液による急性腎障害の治療効果の解明2023
- Author(s)
  佐野瑞季, 小関優太郎, 柴田佳太, 藤澤知弘, 野部浩司
- Organizer
  第149回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] SMTP-44Dの糖尿病性腎症に対する腎保護作用に関する研究2023
- Author(s)
  粟根大揮, 佐々木隼, 柴田佳太, 蓮見惠司, 野部浩司
- Organizer
  第149回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] メカニカルストレスによる化学療法誘発性末梢神経障害モデルマウスの皮膚構造改善効果の検討2023
- Author(s)
  篠内良介, 佐々木晶子, 柴田佳太, 古林創史, 芦野隆, 高木孝士, 辻まゆみ, 木内祐二, 野部浩司
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] 糖尿病性腎症モデルマウスに対するSMTP-44Dの腎保護作用に関する研究2023
- Author(s)
  粟根大揮, 佐々木隼, 中村祐輝, 中村妃奈子, 柴田佳太, 蓮見惠司, 野部浩司
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] SMTP-44DはApoE欠損マウスの動脈硬化進展を抑制する2023
- Author(s)
  寺崎道重, 柴田佳太, 森雄作, 斎藤智美, 松井孝憲, 八島広典, 大坂直也, 藤川大輝, 高畑洋, 広村宗範, 竹鼻伸晃, 高橋範之, 江波戸彩乃, 小原信, 福井智康, 蓮見惠司, 東元祐一郎, 野部浩司, 山岸昌一
- Organizer
  第23回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] 3-Amino-4-hydroxy benzoic acid は NASH モデルにおいて肝機能および線維化を改善する2023
- Author(s)
  山口智亮, 柴田佳太, 蓮見惠司, 野部浩司
- Organizer
  第149回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] Calcineurin B homologous protein 3 facilitates the skeletal muscle development2022
- Author(s)
  古林創史、野部浩司
- Organizer
  第96回薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06774
[Presentation] Mechanisms of the Antioxidant and Anti-inflammatory of SMTP-44D through Its Soluble Epoxide Hydrolase Inhibitory Action2022
- Author(s)
  Shinouchi R, Shibata K, Hasumi K, Nobe K
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] ハンドセラピー施術と冷却法の併用によるCIPNしびれ予防改善効果とメカニズムの解明2022
- Author(s)
  佐々木晶子, 篠内良介, 柴田佳太, 古林創史, 芦野隆, 坂井信裕, 山口真帆, 佐藤ゆり絵, 細沼雅弘, 辻まゆみ, 野部浩司, 木内祐二, 垂野香苗, 中村清吾
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] Efficacy of an alkali extract of Sasa sp. in a mouse model of acute kidney injury2022
- Author(s)
  Koseki Y, Shibata K, Fujisawa T, Nobe K
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K08318
[Presentation] Effect of high extracellular glucose on fibroblast contraction in a wound healing model2016
- Author(s)
  Koji Nobe, Hiromi Nobe, Yasuhiro Takenouchi, Yang-II Fang, Terumasa Hashimoto, Keizo Kasono
- Organizer
  日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26460346
[Presentation] Distinct a1-adrenaline receptor subtypes contribute to intra- and extra-renal artery contraction in mice2012
- Author(s)
  Nobe K
- Organizer
  第85回・日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21590290
[Presentation] Alteration of mouse interlobar artery contraction in diabetic mouse model2010
- Author(s)
  Nobe K
- Organizer
  第122回・日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-21590290

1. KASONO KEIZO (90177387)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. TAKENOUCHI Yasuhiro (30582233)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. Kobayashi Soushi (50511531)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 柴田佳太 (50727328)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
5. 角田伸代 (60337483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大竹一男 (50337482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 蓮見惠司 (20208474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 寺崎道重 (90621342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MATSUI Takanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 東元祐一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 蓮見恵司

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results

Nobe Koji 野部 浩司

野部 浩司 ノベ コウジ

NOBE KOJI 野部 浩司

Research Projects

Research Products

Co-Researchers

真菌由来天然物を用いた糖尿病性腎症の新たな治療戦略の構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of CHP3 in heart failure induced by diabetes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The investigations of the effects of fatty acids consumption or direct administration on the functions of cardiovascular system.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of insulin treatment-induced hypertension in diabetes mellitusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The investigations of the effects of fatty acids administration on the functions of aorta

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of micro-vascular dysfunctions in diabetic complications.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

創傷治癒における線維芽細胞収縮機構の解明〜三次元培養細胞モデルを用いた新しいアプローチによる検討〜Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ジアシルグリセロールキナーゼ活性化の解析およびその糖尿病への関与に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Potent Efficacy of 3-Amino-4-hydroxy Benzoic Acid, a Small Molecule Having Anti-fibrotic Activity, in a Mouse Model of Non-alcoholic Steatohepatitis2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Therapeutic effects of the alkaline extract of leaves of Sasa sp. and elucidation of its mechanism in acute kidney injury2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SMTP-44D inhibits atherosclerotic plaque formation in apolipoprotein-E null mice partly by suppressing the AGEs-RAGE axis.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of SMTP-7 on Cisplatin-Induced Nephrotoxicity in Mice2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

Nobe Koji 野部浩司

野部浩司ノベコウジ

NOBE KOJI 野部浩司