Yamazaki Naoki 山崎直毅

… Alternative Names

YAMAZAKI Naoki 山崎直毅

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Researcher Number	30277264
Other IDs
External Links
Affiliation (Current)	2025: 医療創生大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2007: いわき明星大学, 薬学部, 准教授 1996 – 2006: 東京薬科大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Chemical pharmacy / Chemical pharmacy Except Principal Investigator Chemical pharmacy / Science and Engineering
Keywords	Principal Investigator 海洋アルカロイド / marine sponge / (1S,4S,8aR)-stellettamide C / (-)-stellettamide B / (+)-stellettamide A / 抗腫瘍活性 / anti-Bredt iminium ion / anti tumor activities / intramolecular reductive amination / hydrogenation of bridge head iminium ion … More / N, O-acetalization / cross-coupling reaction / macrocyclization / madangamine / marine alkaloid / Rubottom酸化 / 環状N, O-アセタール / マダガミン / 閉環メタセシス / 2-アザビシクロノナン / 環状N,O-アセタール / 還元的アミノ化 / 天然物化学 / 分子内還元的アミノ化 / 橋頭位水素化 / N, O-アセタール / クロスカップリング / マクロ環化 / マダンガミン / nitrogen containing natural products / ( R )-2-(1-aminoethyl)phenol / antifungal activity / calmodulin inhibitor / A^<1,3> strain / 抗菌作用 / RNA切断活性 / 不斉アリル化 / 四級窒素 / 全合成 / 含窒素天然物 / (R)-2-(1-aminoethyl)phenol / 抗真菌活性 / カルモジュリン阻害活性 / Xestosponigia ingens / 橋頭位イミニウム / 2-azatricyclo[3.3.1]nonane / 海洋性アルカロイド / madangamine A / アザトリシクロ化合物 / 橋頭位アルキル化 / 免疫抑制薬 / 2-azabicyclo[3.3.1]nonane / 5-azatricyclo[6.3.1.0^<1,5>]dodecane / FR901483 / 抗HIV / イソキノリン / Grignard試薬 / ベンゾキノリジジンアルカロイド / ジエチルアルミニウムクロリド / (+)-O-メチルサイコトリン / (+)-サイコトリン … More Except Principal Investigator 不斉合成 / ヤドクガエルアルカロイド / エピバチジン / binding affinity / nicotinic acetylcholine receptor / internitrogen distance / oxaspirocyclic analogues / non-opioidal analgesic agent / epibatidine / Dendrobatid alkaloid / ヘテロディールス-アルダー反応 / スピロ化合物 / 非麻薬性鎮痛薬 / 配座固定アナログ / 結合親和性 / ニコチン性アセチルコリン受容体 / 窒素原子間距離 / オキサスピロアナログ / 非オピオイド性鎮痛薬 / palladium-catalyzed carbonylation / exocyclic alkenyl group / asymmetric synthesis / pumiliotoxin 225F / pumiliotoxin A / poison-dart alkaloids / プミリオトキシン 229F / パラジウム触媒カルボニル化反応 / 環外アルケニル基 / プミリオトキシン225F / プミリオトキシンA / intramolecular hetero Diels-Alder reaction / chiral acylnitroso compound / chiral hydroxamic acid / cytotoxicity against human cancer cell lines / decahydroquinoline / tunicate / marine alkaloids / lepadins A,B,C / 不斉反応 / π-スタッキング相互作用 / ヘテロDiels-Alder反応 / 8-ナフチルメントール / アシルニトロソ化合物 / 非オピオイド性鎮痛作用 / 矢毒蛙アルカロイド / 分子内ヘテロディールズ・アルダー反応 / 分子内へテロディールズ・アルダー反応 / キラルアシルニトロソ化合物 / キラルヒドロキサム酸 / ヒト腫瘍細胞増殖抑制活性 / デカヒドロキノリン / 群体ホヤ / 海産アルカロイド / レパジンA,B,C / ベンゾビシクロ[3.2.1]オクタン / 分子内Friedel-Crafts反応 / セファロサイクリジンA / ハイイヌガヤ / アズレノ[5,6-b]フラノン / エンインメタセシス / [3.3]シグマトロピー転位 / ヘデラシンB / ヘデラシンA / カキドオシ / オクタヒドロアズレノ[5.6-b]フラノン / ヘデラシンA及びB / 抗腫瘍性アルカロイド / セイヨウカキドオシ / アザビシクロ[3.3.1]ノナン / N.O-アセタール化 / マダンガミンA Less

多環式含窒素分子骨格構築法の開発と生体機能アルカロイドの合成
- Principal Investigator
  
  AOYAGI Sakae, KIBAYASHI Chihiro
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo University of Pharmacy and Life Science
Synthetic Studies of the Marine Alkaloids, Madangamines with Anti Tumor ActivitiesPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Naoki
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Sciences
Enantioselective Total Synthesis of Marine Alkaloids StellettamidesPrincipal Investigator
- Principal Investigator
  
  YAMAZAK Inaoki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Synthesis of Conformationally Constrained Analogues of Epibatidine and Development of Non-opioidal Analgesics
- Principal Investigator
  
  KIBAYASHI Chihiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
含窒素五環性骨格を有する抗腫瘍活性物質マダンガミンAの全合成研究Principal Investigator
- Principal Investigator
  
  山崎直毅
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Asymmetric Synthesis of Poison-Dart Alkaloids Pumiliotoxins
- Principal Investigator
  
  KIBAYASHI Chihiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy & Life Science
新規含窒素三環系骨格を有する免疫抑制薬FR901483の全合成研究Principal Investigator
- Principal Investigator
  
  山崎直毅
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
抗HIV活性を有する(+)-サイコトリンのキラル合成Principal Investigator
- Principal Investigator
  
  山崎直毅
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Chiral Synthesis of New Biologically Active Alkaloids Utilizing Hetero Diels-Alder Reaction
- Principal Investigator
  
  KIBAYASHI Chihiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy & Life Science

All 2008 2006 2004 2003

All Journal Article

[Journal Article] Asymmetric synthesis of stellettamides A and C2008
- Author(s)
  Naoki Yamazaki
- Journal Title
  
  Heterocycles 75
  
  Pages: 285-290
- NAID
  40015837383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073218
[Journal Article] Synthesis of the 11-Membered Ring of the Marine Alkaloids, Madangamines2006
- Author(s)
  Yoshimura, Y.; Inoue, J.; Yamazaki, N.; Aoyagi, S.; Kibayashi, C.
- Journal Title
  
  Tetrahedron Letters 47
  
  Pages: 3489-3492
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590025
[Journal Article] Synthesis of the 11-membered ring of the marine alkaloids, madangamines2006
- Author(s)
  Yoshimura, Y., Inoue, J., Yamazaki, N., Aoyagi, S., Kibayashi, C.
- Journal Title
  
  Tetrahedron Lett. 47・20
  
  Pages: 3489-3492
- Data Source
  KAKENHI-PROJECT-15590025
[Journal Article] Synthesis of the 11-Membered Ring of the Marine Alkaloids, Madangamines2006
- Author(s)
  Yoshimura, Y., Inoue, J., Yamazaki, N., Aoyagi, S., Kibayashi, C.
- Journal Title
  
  Tetrahedron Letters 47
  
  Pages: 3489-3492
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590025
[Journal Article] Synthesis of the eleven-membered ring of the marine alkaloids, madangamines2006
- Author(s)
  Y.Yoshimura, J.Inoue, N.Yamazaki, S.Aoyagi, C.Kibayashi
- Journal Title
  
  Tetrahedron Lett. 47・20
  
  Pages: 3489-3489
- Data Source
  KAKENHI-PROJECT-16073218
[Journal Article] Synthesis of the Diazatricyclic Core of the Marine Alkaloids Madangamines2004
- Author(s)
  Yamazaki, N.; Kusanagi, T.; Kibayashi, C.
- Journal Title
  
  Tetrahedron Letters 45
  
  Pages: 6509-6512
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590025
[Journal Article] Synthesis of the Diazatricyclic Core of the Marine Alkaloids Madangamines2004
- Author(s)
  Naoki Yamazaki, Takahiko Kusanagi, Chihiro Kibayashi
- Journal Title
  
  Tetrahedron Letters 45
  
  Pages: 6509-6512
- Data Source
  KAKENHI-PROJECT-15590025
[Journal Article] Synthesis of the Diazatricyclic Core of the Marine Alkaloids Madangamines2004
- Author(s)
  Yamazaki, N., Kusanagi, T., Kibayashi, C.
- Journal Title
  
  Tetrahedron Letters 45
  
  Pages: 6509-6512
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590025
[Journal Article] 環状N,O-アセタールを利用するアルカロイド合成2003
- Author(s)
  山崎直毅, 樹林千尋
- Journal Title
  
  有機合成化学協会誌 61・9
  
  Pages: 868-881
- NAID
  10011907694
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590025
[Journal Article] Alkaloid Synthesis Utilizing Cyclic N, O-Acetals2003
- Author(s)
  Yamazaki, N.; Kibayashi, C.
- Journal Title
  
  Yuki Gosei Kagaku Kyokaishi 61
  
  Pages: 868-881
- NAID
  10011907694
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590025

1. AOYAGI Sakae (30212385)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
2. KIBAYASHI Chihiro (80057330)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. ABE Hideki (00328551)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results

Yamazaki Naoki 山崎 直毅

YAMAZAKI Naoki 山崎 直毅

Research Projects

Research Products

Co-Researchers

多環式含窒素分子骨格構築法の開発と生体機能アルカロイドの合成

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthetic Studies of the Marine Alkaloids, Madangamines with Anti Tumor ActivitiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Enantioselective Total Synthesis of Marine Alkaloids StellettamidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of Conformationally Constrained Analogues of Epibatidine and Development of Non-opioidal Analgesics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

含窒素五環性骨格を有する抗腫瘍活性物質マダンガミンAの全合成研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Asymmetric Synthesis of Poison-Dart Alkaloids Pumiliotoxins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規含窒素三環系骨格を有する免疫抑制薬FR901483の全合成研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗HIV活性を有する(+)-サイコトリンのキラル合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chiral Synthesis of New Biologically Active Alkaloids Utilizing Hetero Diels-Alder Reaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Asymmetric synthesis of stellettamides A and C2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Synthesis of the 11-Membered Ring of the Marine Alkaloids, Madangamines2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis of the 11-membered ring of the marine alkaloids, madangamines2006

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of the 11-Membered Ring of the Marine Alkaloids, Madangamines2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis of the eleven-membered ring of the marine alkaloids, madangamines2006

Author(s)

Yamazaki Naoki 山崎直毅

YAMAZAKI Naoki 山崎直毅