Ito Yukako 伊藤由佳子

… Alternative Names

ITO Yukako 伊藤由佳子

YOSHIKAWA Yukako 吉川由佳子

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Researcher Number	30278444
Other IDs
External Links
Affiliation (Current)	2025: 京都薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2012 – 2024: 京都薬科大学, 薬学部, 講師 2007: Kyoto Pharmaceutical University, Department of Pharmacokinetics, Post-doctoral research fellow 2004 – 2006: 京都薬科大学, 薬学部, 助手 2002: Kyoto Pharmaceutical University Department of Pharmacokinetics Associate Professor, 薬物動態, 助手 2002: 京都薬科大学, 薬物動態学, 助手 … More 2001: 京都薬科大学, 薬物動態学教室, 助手 1998 – 2001: 京都薬科大学, 薬学部, 助手 1995: Kyoto Pharmaceutical University, Department of pharmaceutics, Assistant, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator 応用薬理学・医療系薬学 / 医薬分子機能学 / Microdevices/Nanodevices / Nanomaterials/Nanobioscience
Keywords	Principal Investigator PK/PD / PK-PD / 血中循環腫瘍細胞 / リキッドバイオプシー / 膵癌 / バイオマーカー / 癌化学療法 / circulating tumor cell / CTC / ＰＫ／ＰＤ … More / 大腸がん / 個別化医療 / 抗がん剤 / 膵癌化学療法 / ＦＯＬＦＩＲＩＮＯＸ / すい臓がん / 同所移植 / ＰＫ／ＰＤ解析 / 末しょう神経障害 / がん化学療法 / 末梢神経障害 / オキサリプラチン / PK/PD解析 / ５－FU / 抗癌剤 / ５－ＦＵ / 大腸癌 / 個別医療 / DDS / 薬物動態 … More Except Principal Investigator DDS / 蛋白薬 / LC-MS-MS / bioavailability / Labrasol / experimental animals / skin / absorption / percutaneous / insulin / Microneedles / 徐放性マイクロニードル / 安全性 / 生理学的有効性 / 血糖降下作用 / 含量 / 安定性 / 動物実験 / 経皮吸収 / 高分子薬 / ペプチド / マイクロニードル / インスリン / rat / absorption enhancer / erythropoietin / protein drug / carrier / absorption enhancing / oral DDS / Carbon nanaotubes / インターフェロン / ラット / 吸収促進剤 / エリスロポエチン / キャリヤー / 吸収促進 / 経口DDS / カーボンナノチューブ / Pharmacokinetics / Bioavailability / Gentamicin / Vancomycin / Vitamine E TPGS / Glycopeptides / 腸管排泄機構 / 低バイオアベイラビリティ / 自己乳化型製剤 / ゲンタマイシン / pharmacokinetics / gentamicin / vancomycin / vitamin E TPGS / glycopeptides / protection / microsphere capsule / colonic delivery / ulcerative colitis / ellagic acid / polyphenol / 抗酸化作用 / モノクロラミン胃損傷 / 炎症性病変 / 保護効果 / 圧感応性カプセル / 大腸デリバリー / 潰瘍性大腸炎 / エラグ酸 / ポリフェノール / Transport / Caco-2 cells / Carboplatin / Cisplatin / anti-cancer drug / 低吸収性制癌剤 / Caco-2細胞 / 輸送 / Caco-2 細胞 / カルボプラチン / シスプラチン / 制癌剤 / Bioadhesive / Lymphatic tissue / Liposome / Molecular level Modification / Immunosuppressant / Cyclospor in A / リンパ系組織 / リポソーム / マイクロスフェア / 生体粘着性 / リンパ組織 / リポゾーム / 分子修飾 / 免疫抑制剤 / シクロスポリンA / マイクロ・ナノデバイス / 免疫学 / 薬学 / マイクロアレイ / 感染症 / マイクロナノデバイス / マイクロファブリケーション Less

Clinical feasibility of multidisciplinary treatment algorithm with circulating tumor cells for pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  伊藤由佳子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kyoto Pharmaceutical University
Practical utility of liquid biopsy for management of pancreatic cancer chemotherapyPrincipal Investigator
- Principal Investigator
  
  Ito Yukako
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kyoto Pharmaceutical University
Liquid biopsy for management of pancreatic cancer chemotherapyPrincipal Investigator
- Principal Investigator
  
  Ito Yukako
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kyoto Pharmaceutical University
Novel systmen for predicting adverse effect of neuropathy in oxaliplatin based chemotherapyPrincipal Investigator
- Principal Investigator
  
  Ito Yukako
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Novel monitoring system of fluoropyrimidines for personalized therapy based on PK/PD modeling using dihydropyrimidine dehydrogenase activity as a biomarker of predicting efficacy and side-effects.Principal Investigator
- Principal Investigator
  
  ITO Yukako
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Microneedle skin vaccine
- Principal Investigator
  
  TAKADA Kanji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Microdevices/Nanodevices
- Research Institution
  Kyoto Pharmaceutical University
Insulin microneedle DDS
- Principal Investigator
  
  TAKADA Kanji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Microdevices/Nanodevices
- Research Institution
  Kyoto Pharmaceutical University
Application of carbon nanotubes to DDS carrier
- Principal Investigator
  
  TAKADA Kanji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nanomaterials/Nanobioscience
- Research Institution
  Kyoto Pharmaceutical University
Evaluation and improvement for poor bioavailability of aminoglycosides in the intestinal tract after oral administration
- Principal Investigator
  
  HAKADA Kanji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Department of Pharmacokinetics, Kyoto Pharmaceutical University
Protection against dextran sulfate sodium-induced colitis by microsheres of polyphenol (ellagic acid)
- Principal Investigator
  
  TAKEUCHI Koji
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyoto Pharmaceutical University
Absorption mechanism of low bioavailability anti-cancer drug
- Principal Investigator
  
  TAKADA Kanji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyoto Pharmaceutical University
Enhanced Efficacy of Immunosuppressant by Modification at Molecular Level
- Principal Investigator
  
  TAKADA Kanji
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kyoto Pharmaceutical University

[Book] 実践薬物速度論第2版2023
- Author(s)
  栄田敏之、西川元也 (編著)・栄田敏之、西川元也、伊藤由佳子、草森浩輔、河渕真治（著者）
- Total Pages
  130
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-21K06679
[Book] Handbook of Pharmaceutical Biotechnology, Chapter 6.3."Pharma cokinetics"ed by Shayne Cox Gad.2007
- Author(s)
  Nobuhito Shibata, Yukako Ito and Kanji Takada
- Publisher
  Wiley-Interscience
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Book] Handbook of Pharmaceutical Biotechnology, Chapter 6.3."Pharmacokinetics"ed by Shayne Cox Gad2007
- Author(s)
  Nobuhito Shibata, Yukako Ito and Kanji Takada
- Publisher
  Wiley-Interscience
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Pharmacokinetic-toxicodynamic Modeling to Elucidate the Involvement of Dorsal Root Ganglion Neuron in Oxaliplatin-induced Peripheral Neuropathy2024
- Author(s)
  TSUKUSHI YASUHITO、KOBUCHI SHINJI、ITO YUKAKO、SAKAEDA TOSHIYUKI
- Journal Title
  
  Anticancer Research
  
  Volume: 44 Issue: 2 Pages: 575-584
- DOI
  10.21873/anticanres.16846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
[Journal Article] A Pharmacokinetic-Pharmacodynamic Model Predicts Uracil-tegafur Effect on Tumor Shrinkage and Myelosuppression in a Colorectal Cancer Rat Model2023
- Author(s)
  KOBUCHI SHINJI、TSUDA MOTOI、OKAMURA MAKI、NAKAMURA TAKANORI、ITO YUKAKO
- Journal Title
  
  Anticancer Research
  
  Volume: 43 Issue: 3 Pages: 1121-1130
- DOI
  10.21873/anticanres.16257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
[Journal Article] Mobilization of Circulating Tumor Cells after Short- and Long-Term FOLFIRINOX and GEM/nab-PTX Chemotherapy in Xenograft Mouse Models of Human Pancreatic Cancer.2023
- Author(s)
  Yukako Ito , Shinji Kobuchi, Amiri Kawakita, Kazuki Tosaka, Yume Matsunaga, Shoma Yoshioka, Shizuka Jonan, Kikuko Amagase, Katsunori Hashimoto, Mitsuro Kanda, Takuya Saito and Hayao Nakanishi
- Journal Title
  
  Cancers
  
  Volume: Nov 20;15(22) Issue: 22 Pages: 5482-5482
- DOI
  10.3390/cancers15225482
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15532, KAKENHI-PROJECT-21K06679
[Journal Article] Pharmacokinetic evaluation of oxaliplatin combined with S-1 (SOX) chemotherapy in a rat model of colorectal cancer with acute kidney injury: predictive renal biomarkers for dose optimisation2023
- Author(s)
  Tanaka Takumi、Kobuchi Shinji、Ito Yukako、Sakaeda Toshiyuki
- Journal Title
  
  Xenobiotica
  
  Volume: 53 Issue: 10-11 Pages: 613-620
- DOI
  10.1080/00498254.2023.2283736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
[Journal Article] Translational PK-PD/TD modeling of antitumor effects and peripheral neuropathy in gemcitabine and nab-paclitaxel chemotherapy from xenograft mice to patients for optimal dose and schedule2023
- Author(s)
  Kobuchi Shinji、Morita Atsuko、Jonan Shizuka、Amagase Kikuko、Ito Yukako
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: 93 Issue: 4 Pages: 365-379
- DOI
  10.1007/s00280-023-04625-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
[Journal Article] Comparing the pharmacokinetics and organ/tissue distribution of anti-methicillin-resistant <i>Staphylococcus aureus</i> agents using a rat model of sepsis2022
- Author(s)
  Kobuchi Shinji、Kanda Naoya、Okumi Taichi、Kano Yuma、Tachi Himawari、Ito Yukako、Sakaeda Toshiyuki
- Journal Title
  
  Xenobiotica
  
  Volume: 52 Issue: 6 Pages: 583-590
- DOI
  10.1080/00498254.2022.2098201
- Data Source
  KAKENHI-PROJECT-21K06679
[Journal Article] Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats2022
- Author(s)
  Kobuchi Shinji、Matsui Megumi、Ito Yukako
- Journal Title
  
  Xenobiotica
  
  Volume: 52 Issue: 7 Pages: 697-706
- DOI
  10.1080/00498254.2022.2142696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
[Journal Article] Assessment of Drug?drug Interaction and Optimization in Capecitabine and Irinotecan Combination Regimen using a Physiologically Based Pharmacokinetic Model2022
- Author(s)
  Sakai Shuhei、Kobuchi Shinji、Ito Yukako、Sakaeda Toshiyuki
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 111 Issue: 5 Pages: 1522-1530
- DOI
  10.1016/j.xphs.2021.12.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
[Journal Article] Population Pharmacokinetic Model-Based Evaluation of Intact Oxaliplatin in Rats with Acute Kidney Injury2021
- Author(s)
  Kobuchi Shinji、Kai Miyu、Ito Yukako
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 24 Pages: 6382-6382
- DOI
  10.3390/cancers13246382
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06679, KAKENHI-PROJECT-21K06720
[Journal Article] A Physiologically Based Pharmacokinetic-Pharmacodynamic Model for Capecitabine in Colorectal Cancer Rats: Simulation of Antitumor Efficacy at Various Administration Schedules2021
- Author(s)
  Sakai Shuhei、Kobuchi Shinji、Ito Yukako、Sakaeda Toshiyuki
- Journal Title
  
  European Journal of Drug Metabolism and Pharmacokinetics
  
  Volume: 46 Issue: 2 Pages: 301-315
- DOI
  10.1007/s13318-021-00674-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14963, KAKENHI-PROJECT-21K06679
[Journal Article] Assessment of pharmacokinetic variations of capecitabine after multiple administration in rats: a physiologically based pharmacokinetic model2020
- Author(s)
  Sakai Shuhei、Kobuchi Shinji、Ito Yukako、Sakaeda Toshiyuki
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: 85 Issue: 5 Pages: 869-880
- DOI
  10.1007/s00280-020-04057-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06765, KAKENHI-PROJECT-18K14963
[Journal Article] Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy2020
- Author(s)
  Kobuchi Shinji、Shimizu Risa、Ito Yukako
- Journal Title
  
  Pharmaceutics
  
  Volume: 12 Issue: 2 Pages: 125-125
- DOI
  10.3390/pharmaceutics12020125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14963, KAKENHI-PROJECT-18K06765
[Journal Article] Effect of intact oxaliplatin in plasma on a cold allodynia after multiple administrations in colorectal cancer model rats.2020
- Author(s)
  Yukako Ito, Shinji Kobuchi, Mako Takesada, Miki Morimoto.
- Journal Title
  
  Ann. Palliat. Med.,
  
  Volume: 9(5) Issue: 5 Pages: 3000-3006
- DOI
  10.21037/apm-20-542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06765, KAKENHI-PROJECT-18K14963
[Journal Article] Cytology-based Detection of Circulating Tumour Cells in Human Pancreatic Cancer Xenograft Models With KRAS Mutation2020
- Author(s)
  ITO YUKAKO、INOUE ERIKO、MATSUI YUKI、KOBUCHI SHINJI、MOYAMA CHIAMI、AMAGASE KIKUKO、YOSHIMURA MAYUMI、IKEHARA YUZURU、NAKATA SUSUMU、NAKANISHI HAYAO
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 12 Pages: 6781-6789
- DOI
  10.21873/anticanres.14701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07682, KAKENHI-PROJECT-18K06692, KAKENHI-PROJECT-18K06765
[Journal Article] Population Pharmacokinetic Model-Based Evaluation of Circadian Variations in Plasma 5-Fluorouracil Concentrations During Long-Term Infusion in Rats: A Comparison With Oral Anticancer Prodrugs2020
- Author(s)
  Kobuchi Shinji、Matsumura Eisuke、Ito Yukako、Sakaeda Toshiyuki
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: - Issue: 7 Pages: 2356-2361
- DOI
  10.1016/j.xphs.2020.04.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14963, KAKENHI-PROJECT-18K06765
[Journal Article] Assessment of oxaliplatin-induced chronic neuropathy and anticancer efficacy through pharmacokinetic and toxicodynamic evaluation of a rat model of colorectal cancer.2019
- Author(s)
  1)Yukako Ito, Shinji Kobuchi, Waki Takesada, Chiharu Takahashi.
- Journal Title
  
  Anticancer Res.
  
  Volume: 39 Issue: 8 Pages: 4207-4213
- DOI
  10.21873/anticanres.13581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06765, KAKENHI-PROJECT-18K14963
[Journal Article] Mechanism-based pharmacokinetic?pharmacodynamic (PK/PD) modeling and simulation of oxaliplatin for hematological toxicity in rats2019
- Author(s)
  Kobuchi Shinji、Katsuyama Yosuke、Ito Yukako
- Journal Title
  
  Xenobiotica
  
  Volume: in press Issue: 2 Pages: 146-153
- DOI
  10.1080/00498254.2019.1601790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06765, KAKENHI-PROJECT-18K14963
[Journal Article] Association between the pharmacokinetics of capecitabine and the plasma dihydrouracil to uracil ratio in rat: A surrogate biomarker for dihydropyrimidine dehydrogenase activity2019
- Author(s)
  Kobuchi Shinji、Akutagawa Mako、Ito Yukako、Sakaeda Toshiyuki
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 40 Issue: 1 Pages: 44-48
- DOI
  10.1002/bdd.2168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14963, KAKENHI-PROJECT-18K06765
[Journal Article] Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats.2018
- Author(s)
  Shinji Kobuchi, Yukiko Yazaki, Yukako Ito, and Toshiyuki Sakaeda
- Journal Title
  
  Eur. J. Pharm. Sci.
  
  Volume: 112 Pages: 152-158
- DOI
  10.1016/j.ejps.2017.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18937, KAKENHI-PROJECT-18K06765
[Journal Article] Pharmacokinetic and toxicodynamic evaluation of oxaliplatin-induced neuropathy and hematological toxicity in rats.2018
- Author(s)
  Yukako Ito, Shinji Kobuchi, Risa Shimizu, Yosuke Katsuyama:
- Journal Title
  
  Cancer Chemother. Pharmacol.,
  
  Volume: 81(1): Issue: 1 Pages: 155-161
- DOI
  10.1007/s00280-017-3485-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08085, KAKENHI-PROJECT-15K18937, KAKENHI-PROJECT-18K06765
[Journal Article] Circadian variations in the pharmacokinetics of the oral anticancer agent tegafur-uracil (UFT) and its metabolites in rats2018
- Author(s)
  Kobuchi Shinji、Ito Yukako、Takamatsu Daiki、Sakaeda Toshiyuki
- Journal Title
  
  European Journal of Pharmaceutical Sciences
  
  Volume: 123 Pages: 452-458
- DOI
  10.1016/j.ejps.2018.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06765, KAKENHI-PROJECT-18K14963
[Journal Article] Dissolving microneedles for enhanced local delivery of capsaicin to rat skin tissue.2017
- Author(s)
  Ito Y, Kobuchi S, Inoue G, Kakumu E, Aoki M, Sakaeda T, Takada K.
- Journal Title
  
  J Drug Target.
  
  Volume: 25 Issue: 5 Pages: 420-424
- DOI
  10.1080/1061186x.2016.1266650
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08085
[Journal Article] Dissolving Microneedles as Skin Allergy Test Device2017
- Author(s)
  Ito Y, Matsumoto K, Osakama N, Yoshioka R, Kobuchi S, Sakaeda T, Takada K.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 4 Pages: 531-534
- DOI
  10.1248/bpb.b16-00768
- NAID
  130005530138
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08085
[Journal Article] Effects of a bolus injection of 5-fluorouracil on dihydropyrimidine dehydrogenase activity in rats receiving continuous infusion of 5-fluorouracil.2016
- Author(s)
  Shinji Kobuchi, Asuka Hayashi, Mayu Taniguchi, Yukako Ito, Takao Tamura and Toshiyuki Sakaeda
- Journal Title
  
  Cancer Chemother. Pharmacol.,
  
  Volume: 78 Issue: 3 Pages: 517-523
- DOI
  10.1007/s00280-016-3105-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08085, KAKENHI-PROJECT-15K18937
[Journal Article] Population pharmacokinetic-pharmacodynamic modeling of 5-fluorouracil for toxicities in rats2016
- Author(s)
  Shinji Kobuchi, Yukako Ito, and Toshiyuki Sakaeda
- Journal Title
  
  Eur. J. Drug Metab. Pharmacokinet.
  
  Volume: 印刷中 Issue: 4 Pages: 707-718
- DOI
  10.1007/s13318-016-0389-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18937, KAKENHI-PROJECT-15K08085
[Journal Article] Population pharmacokinetic modelling and simulation of 5-fluorouracil incorporating a circadian rhythm in rats.2016
- Author(s)
  Kobuchi S, Ito Y, Nakano Y, and Sakaeda T.
- Journal Title
  
  Xenobiotica
  
  Volume: 46 Issue: 7 Pages: 597-604
- DOI
  10.3109/00498254.2015.1100767
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18937, KAKENHI-PROJECT-15K08085
[Journal Article] Five years molecular remission with an increase of WT1-specific CTLs after cessation of WT1 peptide vaccination in a patient with CML.2016
- Author(s)
  Narita M, Masuko M, Takahashi M
- Journal Title
  
  Int J Med Sci
  
  Volume: 13 Issue: 4 Pages: 0-0
- DOI
  10.7150/ijms.13601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591385, KAKENHI-PROJECT-15K08085
[Journal Article] Population pharmacokinetic-pharmacodynamic (PK-PD) modeling of 5-fluorouracil (5-FU) for myelosuppression in rats: predicting the whole time course of alterations of blood cell counts after the administration of various doses of 5-FU2015
- Author(s)
  Yukako Ito, Shinji Kobuchi, Taro Hayakawa, Asako Nishimura, Nobuhito Shibata, and Toshiyuki Sakaeda:
- Journal Title
  
  Drug Metab. Rev
  
  Volume: 47（Ｓ１） Pages: 239-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08085
[Journal Article] Semi-physiological pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation of 5-fluorouracil for thrombocytopenia in rats.2015
- Author(s)
  1)Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Asako Nishimura, Nobuhito Shibata, Kanji Takada, and Toshiyuki Sakaeda:
- Journal Title
  
  Xenobiotica
  
  Volume: 45 Pages: 19-28
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08085
[Journal Article] Semi-physiological pharmacokinetic–pharmacodynamic modeling and simulation of 5-fluorouracil for the whole time course of alterations in leukocyte, neutrophil, and lymphocyte counts in rats.2014
- Author(s)
  Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Shota Kuwano, Akiko Baba, Kota Shinohara, Asako Nishimura, Nobuhito Shibata, and Kanji Takada:
- Journal Title
  
  Xenobiotica,
  
  Volume: 44 Issue: 1 Pages: 804-818
- DOI
  10.3109/00498254.2014.943335
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590223
[Journal Article] Pharmacokinetic–pharmacodynamic (PK-PD) modeling and simulation of 5-fluorouracil for erythropenia in rats.2014
- Author(s)
  Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Asako Nishimura, Nobuhito Shibata, Kanji Takada, and Toshiyuki Sakaeda
- Journal Title
  
  J. Pharmacol. Toxicol. Methods
  
  Volume: 70, Issue: 2 Pages: 134-144
- DOI
  10.1016/j.vascn.2014.07.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590223
[Journal Article] Prolonged hypoglycemic effects obtained by two-layered dissolving microneedles containing insulin glargine2014
- Author(s)
  Yukako Ito, Shinji Kobuchi, Yutaro Takemura, Miki Aoki, Marina Haruna, Toshiyuki Sakaeda, Kanji Takada
- Journal Title
  
  J. Drug Del. Sci. Tech.
  
  Volume: 24, Pages: 601-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590223
[Journal Article] Application of dissolving microneedles to glucose monitoring through dermal interstitial fluid2014
- Author(s)
  Yukako Ito, Mayu Taniguchi, Asuka Hayashi, Miku Anai, Shinya Morita, Emi Ko, Naoko Yoshimoto, Yasuhiro Yoshi, Shinji Kobuchi, Toshiyuki Sakaeda, Kanji Takada: .
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 37, Pages: 1776-1781
- NAID
  130004703897
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590223
[Journal Article] Semi-physiological pharmacokinetic-pharmacodynamic modeling and simulation of 5-fluorouracil for the whole time course of alterations in leukocyte, neutrophil and lymphocyte counts in rats.2014
- Author(s)
  Kobuchi S1, Ito Y, Hayakawa T, Kuwano S, Baba A, Shinohara K, Nishimura A, Shibata N, Takada K.
- Journal Title
  
  Xenobiotica
  
  Volume: 44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590223
[Journal Article] Pharmacokinetic/Pharmacodynamic modeling of 5-fluorouracil by using a biomarker to predict tumor growth in a rat model of colorectal cancer.2013
- Author(s)
  Kobuchi S, Ito Y, Okada K, Imoto K, Kuwano S, Takada K.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 102 Issue: 6 Pages: 2056-67
- DOI
  10.1002/jps.23547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590223
[Journal Article] Pre-therapeutic Assessment of Plasma Dihydrouracil/Uracil Ratio for Predicting the Pharmacokinetic Parameters of 5-Fluorouracil and Tumor Growth in a Rat Model of Colorectal Cancer2013
- Author(s)
  Kobuchi S, Ito Y, Okada K, Imoto K, Kuwano S, Takada K.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 36 Issue: 6 Pages: 907-916
- DOI
  10.1248/bpb.b12-00819
- NAID
  130003361454
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590223
[Journal Article] Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats.2013
- Author(s)
  Kobuchi S, Ito Y, Okada K, Imoto K, Takada K.
- Journal Title
  
  Eur J Drug Metab Pharmacokinet.
  
  Volume: 38 Issue: 3 Pages: 171-181
- DOI
  10.1007/s13318-012-0114-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590223
[Journal Article] Pre-therapeutic assessment of plasma dihydrouracil/uracil ratio for predicting the pharmacokinetic parameters of 5-fluorouracil and tumor growth in a rat model of colorectal cancer.2013
- Author(s)
  8） Shinji Kobuchi, Yukako Ito, Kae Okada, Kazuki Imoto, Shota Kuwano, Kanji Takada
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 36 Pages: 907-16
- NAID
  130003361454
- Data Source
  KAKENHI-PROJECT-24590223
[Journal Article] High percutaneous bioavailability of granisetron by dissolving microneedles.2012
- Author(s)
  Asuka Ikejiri, Yukako Ito and Kanji Takada
- Journal Title
  
  J. Drug. Deliv. Sci. Technol.
  
  Volume: 22 Pages: 500-504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Two- and three-layered Dissolving Microneedles for Transcutaneous Delivery of Model. Vaccine Antigen in Rats.2012
- Author(s)
  Asuka Ikejiri, Seishiro Naito, Yukako Ito and Kanji Takada
- Journal Title
  
  J. Biomaterials. Nanobiotech.
  
  Volume: 3 Pages: 325-334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Transdermal Insulin application system with dissolving microneedles.2012
- Author(s)
  Yukako Ito, Takuya Nakhigashi, NaokoYoshimoto, Yuriko Ueda, Noriyuki Hamasaki, and Kanji Takada
- Journal Title
  
  Diabetes. Technol. Ther.
  
  Volume: 14 Pages: 891-899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Effect of lipophilicity on the bioavailability of drugs after percutaneous administration by dissolving microneedles.2012
- Author(s)
  Ito Y, Yoshimura M, Tanaka T and Takada K.
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 15 Pages: 145-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Transdermal Insulin application system with dissolving microneedle.2012
- Author(s)
  Yukako Ito
- Journal Title
  
  Diabetes Technol. Ther.
  
  Volume: 14 Pages: 891-899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Two-layered dissolving microneedles formulated with intermediate-acting insulin.2012
- Author(s)
  Yukako Ito, Muneyuki Hirono, Keizo Fukushima, Nobuyuki Sugioka and Kanji Takada
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 436 Pages: 387-393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Effect of lipophilicity on the bioavailability of drugs after percutaneous administration by dissolving microneedles.2012
- Author(s)
  Yukako Ito
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 101 Pages: 1145-1156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Antigen-loaded dissolving microneedle array as a novel tool for percutaneous vaccination.2012
- Author(s)
  Seishiro Naito, Yukako Ito, Tomoko Kiyohara, Michiyo Kataoka, Masaki Ochiai and Kanji Takada
- Journal Title
  
  Vaccine
  
  Volume: 30 Pages: 1191-1197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles2011
- Author(s)
  Yukako Ito
- Journal Title
  
  Int.J.Pharm
  
  Volume: 407 Pages: 126-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Two-layered dissolving microneedles for percutaneous delivery of sumatriptan2011
- Author(s)
  Yukako Ito
- Journal Title
  
  Drug.Dev.Ind.Pharm
  
  Volume: 37 Pages: 1387-1393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles.2011
- Author(s)
  Yukako Ito, Hiroshi Murano Noriyuki Hamasaki, Keizo Fukushima and Kanji Takada
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 407 Pages: 126-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Two-layered dissolving microneedles for percutaneous delivery ofsumatriptan.2011
- Author(s)
  Yukako Ito, Sumie Kashihara, Keizo Fukushima and Kanji Takada
- Journal Title
  
  Drug. Dev. Ind. Pharm.
  
  Volume: 37 Pages: 1387-1393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles.2011
- Author(s)
  Y.Ito
- Journal Title
  
  Int.J.Pharmaceut
  
  Volume: 407 Pages: 126-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Insulin micropilescomprising biodegradable polymers for production of a long-term hypoglycemic effect.2011
- Author(s)
  Keizo Fukushima, Yukako Ito, Masahiro Ishihata, Nobuyuki Sugioka and Kanji Takada
- Journal Title
  
  J.Drug Target.
  
  Volume: 19 Pages: 212-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Three-layered microcapsules as a long-term sustained release injection preparation.2010
- Author(s)
  Y.Ito
- Journal Title
  
  Int.J.Pharmaceut
  
  Volume: 384 Pages: 53-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Self-dissoving micropile array tips for percutaneous administration of insulin.2010
- Author(s)
  Yukako Ito, Takenao Yamazaki, Nobuyuki Sugioka and Kanji Takada
- Journal Title
  
  J. Mater. Sci: Mater. Med.
  
  Volume: 21 Pages: 835-841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Self-dissoving micropile array tips as percutaneous delivery system of protein drug.2010
- Author(s)
  Yukako Ito, Ryo Hasegawa, KeizoFukushima, Nobuyuki Sugioka and Kanji Takada
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 33 Pages: 683-690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Permeation enhancement of ascorbic acid by self-dissolving micropile array tip through rat skin.2010
- Author(s)
  Y.Ito
- Journal Title
  
  Chem.Pharm.Bull.
  
  Volume: 58 Pages: 458-463
- NAID
  130000255937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Molecular weight dependence on bioavailability of FITC-dextran after administration of self-dissolving micropile to rat skin.2010
- Author(s)
  Y.Ito
- Journal Title
  
  Drug Dev.Ind.Pharm
  
  Volume: 36 Pages: 845-851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Molecular weight dependence on bioavailability of FITC-dextran after afministration of self-dissolving micropile to rat skin. Drug. Dev.2010
- Author(s)
  Yukako Ito, Ayaka Ise, Nobuyuki Sugioka and Kanji Takada
- Journal Title
  
  Ind. Pharm.
  
  Volume: 36 Pages: 845-851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Self-dissolving microarray chip as percutaneous delivery system of protein drug.2010
- Author(s)
  Y.Ito
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 33 Pages: 683-690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Self-dissolving micropile array tips for percutaneous administration of insulin.2010
- Author(s)
  Y.Ito
- Journal Title
  
  J.Mater.Sci-Mater Med
  
  Volume: 21 Pages: 835-841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310082
[Journal Article] Antihyperglycemic effect of insulin from self-dissolving micropiles in dogs2008
- Author(s)
  Y.Ito, Y.Ohashi, A.Saeki, N.Sugioka and K.Takada
- Journal Title
  
  Chem.Pharm.Bull 56
  
  Pages: 243-246
- NAID
  110006622622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Evaluation of self-dissolving needles containing low molecular weight heparin(LMWH) in rats.2008
- Author(s)
  Y. Ito, A. Murakami, T. Maeda, N. Sugioka, K. Takada
- Journal Title
  
  Int. J. Pharmaceut. 349
  
  Pages: 124-129
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Evaluation of self-dissolving needles containing low molecular weight heparin (LMWH) in rats2008
- Author(s)
  Y.Ito, A.Murakami, T.Maeda, N.Sugioka and K.Takada
- Journal Title
  
  Int.J.Pharmaceut 349
  
  Pages: 124-129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Evaluation of self-dissolving needles containing low molecular weight heparin(LMWH)in rats2008
- Author(s)
  Y.Ito, A.Murakami, T.Maeda, N.Sugioka and K.Takada
- Journal Title
  
  Int.J.Pharmaceut. 349
  
  Pages: 124-129
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Antihyperglycemic effect of insulin from self-dissolving micropiles in dogs.2008
- Author(s)
  Y. Ito, Y. Ohashi, A. Saeki, N. Sugioka, K. Takada
- Journal Title
  
  Chem. Pharm. Bull. 56
  
  Pages: 243-246
- NAID
  110006622622
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Antihyperglycemic effect of insulin from self-dissolving micropiles in dogs2008
- Author(s)
  Y.Ito, Y.Ohashi, A.Saeki, N.Sugioka and K.Takada
- Journal Title
  
  Chem.Pharm.Bull. 56
  
  Pages: 243-246
- NAID
  110006622622
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Percutaneous absorption of interferon-α by self-dissolving micropiles2008
- Author(s)
  Y.Ito, A.Saeki, K.Shiroyama, N.Sugioka and K.Takada
- Journal Title
  
  J.Drug Target 16
  
  Pages: 243-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Handbook of Pharmaceutical Biotechnology Chapter 6.3. Pharmacokinetics2007
- Author(s)
  Nobuhito Shibata, Yukako Ito, Kanji Takada
- Journal Title
  
  Wiley-Interscience. ed by Shayne Cox Gad
  
  Pages: 757-814
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Sustained-release self-dissolving micropiles for percutaneous absorption of insulin in mice2007
- Author(s)
  Y.Ito, E.Hagiwara, A.Saeki, N.Sugioka and K.Takada
- Journal Title
  
  J.Drug Target. 15
  
  Pages: 323-356
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Pharmacokinetic and pharmacodynamic studies following percutaneous absorption of erythropoietin micropiles to rats2007
- Author(s)
  Y.Ito, K.Shiroyama, J.Yoshimitsu, Y.Ohashi, N.Sugioka and K.Takada
- Journal Title
  
  J.Control.Rel. 121
  
  Pages: 176-180
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Sustained-release self-dissolving micropiles for percutaneous absorption of insulin in mice.2007
- Author(s)
  Y. Ito, E. Hagiwara, A. Saeki, N. Sugioka, K. Takada
- Journal Title
  
  J. Drug Target. 15
  
  Pages: 323-356
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Pharmacokinetic and pharmacodynamic studies following percutaneous absorption of erythropoietin micropiles to rats2007
- Author(s)
  Y.Ito, K.Shiroyama, J.Yoshimitsu, YOhashi, N.Sugioka and K.Takada
- Journal Title
  
  J.Control.Rel. 121
  
  Pages: 176-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Sustained-release self-dissolving micropiles for percutaneous absorption of insulin in mice2007
- Author(s)
  Y.Ito, E.Hagiwara, A.Saeki, N.Sugioka and K.Takada
- Journal Title
  
  J.Drug Target 15
  
  Pages: 323-356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Pharmacokinetic and pharmacodynamic studies following percutaneous absorption of erythropoietin micropiles to rats.2007
- Author(s)
  Y. Ito, K. Shiroyama, J. Yoshimitsu, Y. Ohashi, N. Sugioka, K. Takada
- Journal Title
  
  J. Control. Rel. 121
  
  Pages: 176-180
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Feasibility of microneedles for percutaneous absorption of insulin2006
- Author(s)
  Y.Ito, E.Hagiwara, A.Saeki, N.Sugioka and K.Takada
- Journal Title
  
  Europ.J.Pharmaceut.Sci. 29
  
  Pages: 82-88
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Self-dissolving microneedles for the percutaneous absorption of EPO in mice.2006
- Author(s)
  Ito Y, Yoshimitsu J, Shiroyama K, Sugioka N, Takada K.
- Journal Title
  
  J. Drug Targeting 14(5)
  
  Pages: 255-261
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Feasibility of microneedles for percutaneous absorption of insulin.2006
- Author(s)
  Ito Y, Hagiwara E, Saeki A, Sugioka N, Takada K.
- Journal Title
  
  European J. Pharmaceutical Sciences 29(1)
  
  Pages: 82-88
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Self-dissolving microneedles for the percutaneous absorption of EPO in mice.2006
- Author(s)
  Y. Ito, J. I. Yoshimitsu, K. Shiroyama, N. Sugioka, K. Takada
- Journal Title
  
  J. Drug Target. 14
  
  Pages: 255-262
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Self-dissolving microneedles fir the percutaneous absorption of EPO in mice2006
- Author(s)
  Y.Ito, J.I.Yoshimitsu, K.Shiroyama, N.Sugioka and K.Takada
- Journal Title
  
  J.Drug Target. 14
  
  Pages: 255-262
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Feasibility of microneedles for percutaneous absorption of insulin.2006
- Author(s)
  Y. Ito, E. Hagiwara, A. Saeki, N. Sugioka, K. Takada
- Journal Title
  
  Europ. J. Pharmaceut. Sci. 29
  
  Pages: 82-88
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Journal Article] Liquid filled nanoparticles as a drug delivery tool for protein therapeutics2005
- Author(s)
  N.Venkatesan, J.Yoshimitsu, Y.Ito, N.Shibata, K.Takada
- Journal Title
  
  Biomaterials 26
  
  Pages: 7154-7163
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16310091
[Journal Article] カーボンナノチューブの経口DDSとしての利用2005
- Author(s)
  吉光, Venkatesan, 内藤, 伊藤, 芝田, 高田
- Journal Title
  
  薬剤学:日本薬剤学会創立20周年記念大会講演要旨集
  
  Pages: 226-226
- Data Source
  KAKENHI-PROJECT-16310091
[Journal Article] Liquid filled nanoparticles as a drug delivery tool for protein therapeutics2005
- Author(s)
  N.Venkatesan, J.Yoshimitsu, Y.Ito, N.Shibata, K.Takada
- Journal Title
  
  Biomaterials Vol.26
  
  Pages: 7154-7163
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16310091
[Journal Article] Liquid formulation holding nano-particlate system (LFNPS) for oral delivery of Erythropoietin (EPO).2004
- Author(s)
  K.Takada, N.Venkatesan, Y.Ito, N.Shibata, H.Ichihashi
- Journal Title
  
  Proceeding of AAPS Annual Meeting and Exposition November 10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16310091
[Journal Article] Liquid formulation holding nano-particulate system (LFNPS) for oral delivery of erythropoietin and interferon2004
- Author(s)
  K.Takada, N.Venkatesan, B.Tosh, Y.Ito, N.Shibata
- Journal Title
  
  2004 AAPS Annual Meeting and Exposition Nov.7-11
  
  Pages: 93-93
- Data Source
  KAKENHI-PROJECT-16310091
[Journal Article] Liquid formulation holding nano-particlate system (LFNPS) for oral delivery of Erythropoietin (EPO).2004
- Author(s)
  K.Takada, N.Venkatesan, Y.Ito, N.Shibata, H.Ichihashi
- Journal Title
  
  Proceeding of AAPS Annual Meeting and Exposition, November 10,2004. 2004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16310091
[Journal Article] Effect of fiber length of carbon nanotubes on the absorption of erythropoietin from rat small intestine
- Author(s)
  Y.Ito, N.Venkatesan, N.Hirako, N.Sugioka, K.Takada
- Journal Title
  
  Int. J. Pharmaceutics (submitted)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16310091
[Journal Article] Effect of fiber length of carbon nanotubes on the absorption of erythropoietin from rat small intestine
- Author(s)
  Y.Ito, N.Venkatesan, N.Hirako, N.Sugioka, K.Takada
- Journal Title
  
  Int.J.Pharmaceutics (submitted)
- Data Source
  KAKENHI-PROJECT-16310091
[Journal Article] Effect of fiber length of carbon nanotubes on the absorption of erythropoietin from rat small intestine
- Author(s)
  Y.Ito, N.Venkatesan, N.Hirako, N.Sugioka, K.Takada
- Journal Title
  
  Int.J.Pharmaceutics (submitted)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16310091
[Presentation] リキッドバイオプシーによる膵癌化学療法時の血中循環腫瘍細胞動態2023
- Author(s)
  松永夢, 吉岡祥眞, 上南静佳, 河渕真治, 天ヶ瀬紀久子, 中西速夫, 栄田敏之, 伊藤由佳子
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] 末梢神経障害マネジメントに向けたクロノセラピー導入XELOX療法の提案2023
- Author(s)
  竹若政国, 河渕真治, 栄田敏之, 伊藤由佳子
- Organizer
  第97回日本薬理学会年会/第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Risk factor analysis for acute kidney injury during cancer chemotherapy in colorectal cancer with AKI model rats2023
- Author(s)
  Akari Yoshimoto, Kaito Shinzatio, Takumi Tanaka, Shinji Kobuchi, Yuuki Otsuka, Kikuko Amagase, Toshiyuki Sakaeda, Yukako Ito
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] FOLFIRINOX長期治療時のモデリング＆シミュレーションアプローチによる予後予測の検討2023
- Author(s)
  登坂一樹, 川北亜実莉, 伊藤由佳子, 河渕真治, 栄田敏之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Preventive effect of omeprazole as drug repositioning strategy on onset of OIPN2023
- Author(s)
  Yasuhito Tsukushi, Shinji Kobuchi, Yukako Ito and Toshiyuki Sakaeda
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] 膵癌化学療法中の骨髄抑制予防のための用量調節の可能性2023
- Author(s)
  寺内涼音, 吉岡宏祐, 河渕真治, 栄田敏之, 伊藤由佳子
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Pharmacokinetics and biomarker analysis of SOX chemotherapy in chronic kidney disease model rats2023
- Author(s)
  Takumi Tanaka, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] 急性腎障害発症時のXELOX療法の用量調節に関する検討2023
- Author(s)
  新里海翔, 吉本朱里, 田中拓実, 河渕真治, 栄田敏之, 伊藤由佳子
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] equential detection of circulating tumor cells by liquid biopsy after long-term therapy in pancreatic cancer mice2022
- Author(s)
  Kawakita Amiri, Ito Yukako, Kobuchi Shinji, Jonan Shizuka, Amagase Kikuko, Sakaeda Toshiyuki and Nakanishi Hayao
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Explorative study for dose limiting factor in acute kidney injury during SOX treatment by population pharmacokinetic approach2022
- Author(s)
  Kouno Michi, Tanaka Takumi, Kobuchi Shinji, Sakaeda Toshiyuki, Ito Yukako
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Pharmacokinetic/toxicodynamic modeling to elucidate the roles of dorsal root ganglion neuron in oxaliplatin-induced peripheral neuropathy2022
- Author(s)
  Tsukushi Yasuhito, Kobuchi Shinji, Ito Yukako, Sakaeda Toshiyuki
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] SOX療法施行時におけるオキサリプラチンの後根神経節への移行性2022
- Author(s)
  柴田詩歩, 北本隆晃, 佐竹智規, 宇野りつ夏, 河渕真治, 伊藤由佳子, 栄田敏之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] がん診療時の急性腎障害発症によるcapecitabine体内動態の変動2022
- Author(s)
  上浦順子、河渕真治、栄田敏之、伊藤由佳子
- Organizer
  第96回日本薬理学会年会／第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] FOLFIRINOX療法の骨髄抑制に関する薬物動態／毒性薬力学的評価2022
- Author(s)
  三井和樹、水本萌、河渕真治、栄田敏之、伊藤由佳子
- Organizer
  第96回日本薬理学会年会／第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] SOX療法時の腎障害に対する至適用量の検討2022
- Author(s)
  髙田和明, 河渕真治, 伊藤由佳子, 栄田敏之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Role of uracil and dihydrouracil plasma ratio as a fluoropyrimidine-related toxicity biomarker in FOLFIRINOX treatment to pancreatic cancer model rats2022
- Author(s)
  Mizumoto Moe, Kobuchi Shinji, Sakaeda Toshiyuki, Ito Yukako
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Alternative proposal of dose reduction method of capecitabine for cancer patients with pre-existing chronic kidney disease2022
- Author(s)
  Taraki Moe, Kobuchi Shinji, Sakaeda Toshiyuki, Ito Yukako
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] 急性腎障害発症が及ぼすSOX ( S-1 + オキサリプラチン)療法の予後への影響2022
- Author(s)
  田中拓実、河渕真治、伊藤由佳子、栄田敏之
- Organizer
  第96回日本薬理学会年会／第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] SOX療法時におけるオキサリプラチンの後根神経節中への移行性と概日リズムとの関連性2022
- Author(s)
  池本生、河渕真治、栄田敏之、伊藤由佳子
- Organizer
  第96回日本薬理学会年会／第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Physiologically based pharmacokinetic model for drug-drug interaction in XELIRI regimen,2021
- Author(s)
  Sakai Shuhei; Kobuchi Shinji; Ito Yukako; Sakaeda Toshiyuki.
- Organizer
  第80回日本癌学会学術総会,横浜,2021.9.
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] SOX療法時の腎障害に対する至適用量の検討2021
- Author(s)
  髙田和明, 河渕真治, 伊藤由佳子, 栄田敏之.
- Organizer
  ,日本薬学会第142年会,愛知(オンライン開催), 2022.3.
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] 後根神経節中オキサリプラチン分布に対する日内変動の影響2021
- Author(s)
  上田竣太, 河渕真治, 伊藤由佳子, 西田健太郎, 栄田敏之.
- Organizer
  日本薬学会第141年会,広島(オンライン開催),2021. 3
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Pharmacokinetic-pharmacodynamic approach to predict paclitaxel-induced peripheral neuropathy in pancreatic cancer rats.,2021
- Author(s)
  Uno Ritsuka; Kobuchi Shinji; Ito Yukako; Sakaeda Toshiyuki.
- Organizer
  第80回日本癌学会学術総会,横浜,2021.9.
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] 母集団薬物動態解析に基づくTS-1ベース化学療法時の慢性腎障害マネジメントの検討,2021
- Author(s)
  山本彩音, 河渕真治, 伊藤由佳子, 栄田敏之.
- Organizer
  日本薬学会第141年会,広島(オンライン開催),2021.3
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Risk management of peripheral neuropathy by platinum localization in dorsal root ganglion neurons with FOLFIRINOX,2021
- Author(s)
  Kitamoto Takaaki; Kobuchi Shinji; Ito Yukako; Sakaeda Toshiyuki.
- Organizer
  第80回日本癌学会学術総会,横浜,2021.9.
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Utility of circulating tumor cells for GEM＋nab-PTX therapy in pancreatic cancer xenograft model mice,2021
- Author(s)
  Morita Atsuko; Ito Yukako; Kobuchi Shinji; Jonan Shizuka; Amagase Kikuko; Sakaeda Toshiyuki; Nakanishi Hayao.
- Organizer
  第80回日本癌学会学術総会,横浜,2021.9.
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] .FOLFIRINOX療法時の末梢神経障害リスクマネジメントに対するmodeling and simulationの利活用,2021
- Author(s)
  木村寿々奈, 河渕真治, 伊藤由佳子, 栄田敏之
- Organizer
  第42回日本臨床薬理学会学術総会,仙台,2021.12.
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] 母集団薬物動態解析によるTS-1投与後の5-fluorouracilの日内変動の評価,2021
- Author(s)
  佐竹智規, 河渕真治, 伊藤由佳子, 栄田敏之.
- Organizer
  第71回日本薬学会関西支部総会・大会,東大阪(オンライン開催),2021.10.
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] SOX療法施行時におけるオキサリプラチンの後根神経節への移行性,2021
- Author(s)
  柴田詩歩, 北本隆晃, 佐竹智規, 宇野りつ夏, 河渕真治, 伊藤由佳子, 栄田敏之.
- Organizer
  日本薬学会第142年会,愛知(オンライン開催), 2022.3.
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] FOLFIRINOX療法時の血中循環腫瘍細胞を導入した薬物動態学－薬力学的評価法の検討,2021
- Author(s)
  松居祐貴, 井上絵莉子, 伊藤由佳子, 河渕真治, 中西速夫, 栄田敏之.
- Organizer
  日本薬学会第141年会,広島(オンライン開催),2021.3
- Data Source
  KAKENHI-PROJECT-21K06679
[Presentation] Detection of circulating tumor cells in orthotopic vs. subcutaneous GFP-SUIT2 pancreatic cancer xenograft models,2020
- Author(s)
  Eriko Inoue, Yukako Ito, Shinji Kobuchi, Chiami Moyama, Susumu Nakata, Toshiyuki Sakaeda, Hayao Nakanishi,
- Organizer
  第79回日本癌学会学術総会,
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] オキサリプラチンベース化学療法時の慢性腎障害マネジメントのための母集団薬物動態的解析,2020
- Author(s)
  田中愛花，河渕真治，伊藤由佳子, 栄田敏之,
- Organizer
  第41回日本臨床薬理学会学術総会,
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] Effect of platinum accumulation in dorsal root ganglia to neurotoxicity in colorectal cancer rats treated with XELOX,2020
- Author(s)
  Yasuhito Tsukushi, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda,
- Organizer
  第79回日本癌学会学術総会,
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] 膵がんモデルラットに対するゲムシタビン・ナブパクリタキセル療法時のモデリング＆シミュレーションの有用性,2020
- Author(s)
  中村謙吾, 藤井優佳, 河渕真治, 伊藤由佳子, 栄田敏之,
- Organizer
  日本薬学会第140年会,
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] Physiologically based pharmacokinetic-pharmacodynamic model for capecitabine antitumor profile in colorectal cancer rats,2020
- Author(s)
  Shuhei Sakai, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda,
- Organizer
  第79回日本癌学会学術総会, 広島, 2020.9.
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] Physiologically based pharmacokinetic modeling of capecitabine using in vitro enzyme activity after multiple administrations in colorectal cancer rats2019
- Author(s)
  Shuhei Sakai, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda,
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] Risk comparison of fluorouracil-based regimens in myelosuppression and pharmacokinetic profiles2019
- Author(s)
  Shiho Araki, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] Effects of metabolic enzymes on the pharmacokinetics and pharmacodynamics of capecitabine in colorectal cancer rats2019
- Author(s)
  Shuhei Sakai, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] FU代謝に着目した膵癌におけるmFOLFIRINOX治療効果予測因子についての検討2019
- Author(s)
  堀口繁, 伊藤由佳子, 岡田裕之
- Organizer
  JDDW 2019 Kobe
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] 腎機能障害を有する大腸がんモデルラットにおけるオキサリプラチンの母集団薬物動態解析2019
- Author(s)
  疇地優香，河渕真治，伊藤由佳子, 栄田敏之
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] 膵がんモデルラットにおけるFOLFIRINOX療法時の骨髄抑制に関する薬物動態学的・毒性薬理学的評価2019
- Author(s)
  武井慎也, 中村俊, 河渕真治, 伊藤由佳子, 栄田敏之
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] Pharmacokinetic study of SOX (S-1 + Oxaliplatin) regimen to colorectal cancer rats with renal disorder2019
- Author(s)
  Takumi Tanaka, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] 膵癌におけるmFOLFIRINOX 治療効果予測因子についての検討2019
- Author(s)
  堀口繁, 伊藤由佳子, 岡田裕之,
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] Effect of biomarker on pharmacokinetic parameters in FOLFIRINOX treatment to pancreatic cancer model rats2019
- Author(s)
  Shun Nakamura, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] PK-TD modeling for hematologic toxicity in FOLFIRINOX treatment to pancreatic cancer model rats2019
- Author(s)
  Shinya Takei, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] Pharmacokinetic evaluation of TS-1 in renal dysfunction model rats2018
- Author(s)
  14)Mayu Furuke, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda:
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX（Kanazawa, Japan）
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] Association between plasma concentration and myelosuppression of S-1 in Colorectal cancer model rats with SOX regimen2018
- Author(s)
  11)Yuki Shimizu, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] 膵癌化学療法における治療選択バイオマーカーに関する検討2018
- Author(s)
  3)柄田佐和子、伊藤由佳子、河渕真治、堀口繁、加藤博也、白羽英則、栄田敏之
- Organizer
  日本薬学会第138年会（金沢），
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] FOLFIRINOX療法における抗癌剤の体内動態とバイオマーカーに関する検討.2018
- Author(s)
  森わかな、伊藤由佳子、河渕真治、栄田敏之
- Organizer
  日本薬学会第138年会（金沢），
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] Pharmacokinetics and pharmacodynamics of S-1 plus oxaliplatin treatment in colorectal cancer rats2018
- Author(s)
  13)Masashi Mori, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX（
- Data Source
  KAKENHI-PROJECT-18K06765
[Presentation] 膵癌化学療法における治療選択バイオマーカーに関する検討2017
- Author(s)
  柄田佐和子, 伊藤由佳子, 河渕真治, 堀口繁, 加藤博也, 白羽英則, 栄田敏之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] Preclinical and clinical studies on establishment of invasive marker of dihydropyrimidine dehydrogenase activity and its usefulness in 5-fluorouracil-based chemotherapy.2017
- Author(s)
  Yukako Ito, Shinji Kobuchi, Shigeru Horiguchi, Hironari Kato, Hidenori Shiraha, Toshiyuki Sakaeda
- Organizer
  15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 腎障害モデルラットにおける TS-1 の体内動態に関する基礎的検討2017
- Author(s)
  古家真優, 甲斐美優, 河渕真治, 伊藤由佳子, 栄田敏之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 癌化学療法における細胞間質液モニタリングの有用性に関する検討2017
- Author(s)
  徳永寛人, 鶴田弘明, 河渕真治, 伊藤由佳子, 栄田敏之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] Pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation of UFT on multiple dosing in colorectal cancer rats.2017
- Author(s)
  Motoi Tsuda, Maki Okamura, Takanori Nakamura, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 5FU代謝酵素に着目した膵癌におけるFOLFIRINOX治療効果予測因子に関する検討.2017
- Author(s)
  堀口繁、伊藤由佳子、岡田裕之
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] Ｔumoral distribution of tegafur and 5-fluorouracil after UFT administration to colorectal cancer rats.2017
- Author(s)
  Takanori Nakamura, Shinji Kobuchi, Yukako Ito, and Toshiyuki Sakaeda
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] Pharmacokinetics and toxicodynamics of oxaliplatin-induced peripheral neuropathy in colorectal cancer model rats.2017
- Author(s)
  Waki Takesada, Mako Takeda, Miki Morimoto, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] Pharmacokinetic-pharmacodynamic modeling of oxaliplatin for hematological toxicity in rats.2017
- Author(s)
  Yosuke Katsuyama, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] オキサリプラチン誘発蓄積性末梢神経障害の発現予測に関する血漿中オキサリプラチン濃度と総白金濃度との比較2017
- Author(s)
  武田茉子、武貞和希、河渕真治、伊藤由佳子、栄田敏之
- Organizer
  第27回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] オキサリプラチン投与による骨髄抑制発現と体内動態の関連性2017
- Author(s)
  勝山陽介,　清水理紗,　河渕真治,　伊藤由佳子,　栄田敏之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] TS-1 反復投与後の体内動態と DPD 活性に関する基礎的検討2017
- Author(s)
  田野遥, 河渕真治, 伊藤由佳子, 栄田敏之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] イリノテカンの骨髄抑制に関する薬物動態学的/毒性薬力学的評価2017
- Author(s)
  森賢也、西尾夏美、河渕真治、伊藤由佳子、栄田敏之
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 腸がん化学療法における5-フルオロウラシルの血漿中濃度維持に及ぼすイリノテカンの影響.2017
- Author(s)
  西尾夏美、河渕真治、伊藤由佳子、栄田敏之
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 大腸癌モデルラットにおけるオキサリプラチン誘発急性末梢神経障害と血漿中薬物濃度に関する基礎的検討2017
- Author(s)
  森本実希, 武貞和希, 高橋千春, 武田茉子, 河渕真治, 伊藤由佳子, 栄田敏之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 大腸癌モデルラットにおけるオキサリプラチンの体内動態と蓄積性末梢神経障害の評価2017
- Author(s)
  武貞和希，清水理紗，高橋千春，武田茉子，森本実希，河渕真治，伊藤由佳子，栄田敏之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 大腸癌モデルラットにおける UFT 反復投与後の体内動態と治療効果との関係性2017
- Author(s)
  津田基, 岡村真生, 中村貴憲, 河渕真治, 伊藤由佳子, 栄田敏之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] Population pharmacokinetic-pharmacodynamic model of 5-fluorouracil for evaluation of myelosuppression and body weight loss.2017
- Author(s)
  Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda
- Organizer
  15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 大腸がんモデルラットにおけるオキサリプラチン反復投与後の抗腫瘍効果に関する薬物動態学的／薬力学的評価.2017
- Author(s)
  高橋千春、河渕真治、伊藤由佳子、栄田敏之:
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 腎障害時のオキサリプラチン体内動態に関する検討2017
- Author(s)
  甲斐美優, 古家真優, 河渕真治, 伊藤由佳子, 栄田敏之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] FOLFIRINOX療法における抗癌剤の体内動態とバイオマーカーに関する検討2017
- Author(s)
  森わかな, 伊藤由佳子, 河渕真治, 栄田敏之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] Population pharmacokinetic analysis of capecitabine for circadian variations in rats.2016
- Author(s)
  Yukiko Yazaki, Shinji Kobuchi, Yukako Ito and Toshiyuki Sakaeda:
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] カペシタビン反復投与後のカペシタビンの体内動態及び腫瘍内濃度の変動.2016
- Author(s)
  佐藤孝和、能勢祐輔、河渕真治、伊藤由佳子、栄田敏之:
- Organizer
  第1回日本臨床薬理学会近畿地方会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 母集団薬物動態解析によるカペシタビン投与後の5-fluorouracilの日内変動把握.2016
- Author(s)
  矢崎由希子、河渕真治、伊藤由佳子、栄田敏之:
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] Capecitabineの体内動態に及ぼす5-fluorouracil先行急速静脈内投与の影響.2016
- Author(s)
  芥川真子、河渕真治、伊藤由佳子、栄田敏之:
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] オキサリプラチン誘発末梢神経障害の発現リスクと血漿中体内動態との関連性2016
- Author(s)
  清水理紗、高橋千春、武貞和希、武田茉子、森本実希、河渕真治、伊藤由佳子、栄田俊之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜、神奈川
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] umoral distribution of capecitabine and 5-fluorouracil after capecitabine administration to colorectal cancer rats.2016
- Author(s)
  Yusuke Nose, Takakazu Sato, Shinji Kobuchi, Yukako Ito and Toshiyuki Sakaeda:
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] Pharmacokinetic alterations of capecitabine and 5-fluorouracil after repeated administration of capecitabine to rats with colorectal cancer.2015
- Author(s)
  Takakazu Sato, Kota Shinohara, Shinji Kobuchi, Yukako Ito, Toshiyuki Sakaeda：
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] Increase in steady-state plasma concentrations of 5-fluorouracil (5-FU) via the suppression of dihydropyrimidine dehydrogenase activity by a bolus injection of 5-FU in advance.2015
- Author(s)
  Shinji Kobuchi, Yukako Ito, Takao Tamura, and Toshiyuki Sakaeda：
- Organizer
  14th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
- Place of Presentation
  Rotterdam, Netherlands
- Year and Date
  2015-10-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] 5-fluorouracilの急速静脈内投与によるdihydropyrimidine dehydrogenase活性への影響2015
- Author(s)
  林明日香、谷口真優、河渕真治、伊藤由佳子、田村孝雄、栄田敏之：
- Organizer
  . 第36回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-15K08085
[Presentation] PK-PDモデリングによる抗がん剤投与後の血球数時間的推移2014
- Author(s)
  河渕真治、桑野翔太、馬場明子篠原康太、西村亜佐子、早川太朗、伊藤由佳子、芝田信人、高田寛治
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] 大腸癌モデルラットにおける5－フルオロウラシル連続投与時の体内動態及びバイオマーカー変動2013
- Author(s)
  河渕真治，岡田賀衣，井本一樹，桑野翔太，馬場明子，伊藤由佳子，高田寛治
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] Pharmacokinetic-Phamacodynamic (PK-PD) model with predictive biomarker to simulate colorectal tumor growth in rats after 5-fluorouracil treatment.2013
- Author(s)
  Shinji Kobuchi, Yukako Ito, Kanji Takada
- Organizer
  10th International ISSX meeting
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] Plasma dihydrouracil/uracil ratio as a predictive biomarker for the effect and pharmacokinetics of 5-fluorouracil in colorectal tumor growth.2013
- Author(s)
  Yukako Ito, Shinji Kobuchi, Kanji Takada
- Organizer
  10th International ISSX meeting
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] Pharmacokinetic-Phamacodynamic modeling of 5-fluorouracil using the time course of leukocytes and neutrophils for predicting the risk of myelosuppression in rats.2013
- Author(s)
  Shinji Kobuchi, Shota Kuwano, Akiko Baba, Kota Shinohara, Yukako Ito, Kanji Takada
- Organizer
  第28回日本薬物動態学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] PK-PD理論に基づく５－FU投与後の骨髄抑制の予測性.2013
- Author(s)
  河渕真治、桑野翔太、馬場明子、篠原康太、西村亜佐子、早川太朗、伊藤由佳子、芝田信人、高田寛治
- Organizer
  第34回日本臨床薬理学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] 大腸癌ラットにおけるバイオマーカーを用いたPK/PDモデリングによる5-FU抗腫瘍効果予測システム2012
- Author(s)
  河渕真治，岡田賀衣，井本一樹，桑野翔太，馬場明子，伊藤由佳子，高田寛治
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  沖縄コンベンションセンター
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] 大腸癌化学療法における血漿中ジヒドロウラシル/ウラシル比のバイオマーカーとしての有用性2012
- Author(s)
  河渕真治，岡田賀衣，井本一樹，桑野翔太，馬場明子，伊藤由佳子，高田寛治
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  千葉、タワーホール船堀
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] Usefulness of three-layered dissolving microneedles for skin vaccination.2012
- Author(s)
  Kanji Takada, Seoshiro Naito, Yukako Ito, Mangatt Sudhakaran S., Asuka Ikejiri
- Organizer
  第16回日本ワクチン学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22310082
[Presentation] 塩基性繊維芽細胞増殖因子(bFGF)含有マイクロニードル・アレイ・チップに関する基礎的研究.2012
- Author(s)
  高田寛治、小野一郎、伊藤由佳子、上田祐理子、松地大輝、家田和奈、櫻井紀代美
- Organizer
  第42回日本創傷治癒学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22310082
[Presentation] Transdermal insulin application system with dissolvingmicroneedles.2011
- Author(s)
  Kanji Takada, Yukako Ito
- Organizer
  11th Annual DiabetesTechnology Meeting
- Place of Presentation
  San Francisco, U.S. A.
- Data Source
  KAKENHI-PROJECT-22310082
[Presentation] Epidermal vaccination of hepatitis A using a dissolving microneedle array2011
- Author(s)
  Seishiro Naito
- Organizer
  5^<th> Vaccine ISV Annual Global Congress
- Place of Presentation
  Seattle Marriott Waterfront Hotel (Seattle, U.S.A)
- Data Source
  KAKENHI-PROJECT-22310082
[Presentation] Epidermal vaccination of hepatitis A using a dissolving microneedle array.2011
- Author(s)
  Seishiro Naito, Yukako Ito, Tomoko Kiyohara, Michiyo Kataoka, Masaki Ochiai, Kanji Takada
- Organizer
  5th Vaccine ISV Annual Global Congress
- Place of Presentation
  Seattle, U.S.A.
- Data Source
  KAKENHI-PROJECT-22310082
[Presentation] マイクロニードル投与用デバイス.2011
- Author(s)
  濱崎紀行、仲東卓也、伊藤由佳子、高田寛治
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学本郷キャンパス
- Data Source
  KAKENHI-PROJECT-22310082
[Presentation] Factors affecting the bioavailability of drugs from dissolving microneedles in rats.2010
- Author(s)
  Yukako Ito, Keizo Fukushima, Nobuyuki Sugioka and Kanji Takada
- Organizer
  First International Conference on microneedles
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-22310082
[Presentation] Dissolving microneedles for percutaneous delivery ofinsulin. European Association for the study of Diabetes2010
- Author(s)
  Kanji Takada and Yukako Ito
- Organizer
  46th Annual Meeting
- Place of Presentation
  Stockholm, Sweden
- Data Source
  KAKENHI-PROJECT-22310082
[Presentation] 自己溶解性インスリン・マイクロニードル(MN) のPK/PD解析およびグルコース負荷試験(OGTT) よる薬効評価2007
- Author(s)
  中根遥、大橋良徳、石畑雅大、落井裕也、山崎赴尚、伊藤由佳子、杉岡信幸、高田寛治、
- Organizer
  第23回日本DDS学会Ann. Meeting Jap. Soc. Drug Deliv. Sys.
- Place of Presentation
  熊本Kumamoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Presentation] 自己溶解性インスリン・マイクロニードル(MN)のPK/PD解析およびグルコース負荷試験(OGTT)よる薬効評価2007
- Author(s)
  中根遥、大橋良徳、石畑雅大、落井裕也、山崎赳尚、伊藤由佳子、杉岡信幸、高田寛治
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Presentation] Percutaneous delivery of erythropoietin(EPO) and low molecular weight heparin(LMWH) by self-dissolving microneedle(SDMIN).2006
- Author(s)
  Kanji Takada, Yukako Ito, Nobuyuki Sugioka, Aiko Murakami, Atsushi Saeki, Junichiro Yoshimitu
- Organizer
  2006 AAPS National Biotechnology Conference
- Place of Presentation
  Boston, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Presentation] エリスロポエチン・マイクロニードルDDSの設計と薬効評価.2006
- Author(s)
  城山圭司、伊藤由佳子、杉岡信幸、高田寛治、
- Organizer
  第27回日本臨床薬理学会年会Ann. Meeting Jap. Soc. Clin. Pharmacol. Ther.
- Place of Presentation
  東京Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Presentation] Percutaneous delivery of erythropoietin(EPO)and low molecular weight heparin(LMWH)by self-dissolving microneedle(SDMIN)2006
- Author(s)
  K.Takada, Y.Ito, N.Sugioka, A.Murakami, A.Saeki and J.Yoshimitu
- Organizer
  2006 AAPS National Biotechnology Conference
- Place of Presentation
  Boston,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Presentation] エリスロポエチン・マイクロニードルDDSの設計と薬効評価2006
- Author(s)
  城山圭司、伊藤由佳子、杉岡信幸、高田寛治
- Organizer
  第27回日本臨床薬理学会年会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Presentation] 低分子ヘパリン(LMWH)マイクロニードル(MN)製剤の設計と評価2006
- Author(s)
  村上愛子、前田友大、長谷川みのり、芝池知徳、伊勢彩香、伊藤由佳子、杉岡信幸、高田寛治
- Organizer
  第22回日本DDS学会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Presentation] 低分子ヘパリン(LMWH) マイクロニードル(MN) 製剤の設計と評価2006
- Author(s)
  村上愛子、前田友大、長谷川みのり、芝池知徳、伊勢彩香、伊藤由佳子、杉岡信幸、高田寛治、
- Organizer
  第22回日本DDS学会Ann. Meeting Jap. Soc. Drug Deliv. Sys.
- Place of Presentation
  東京Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Presentation] Self-dissolving microneedle(SDMIN) for percutaneous delivery of insulin(INS).2006
- Author(s)
  Kanji Takada, Yukako Ito, Nobuyuki Sugioka, Eiji Hagiwara, Yoshinori Ohashi
- Organizer
  2006 AAPS National Biotechnology ConferenCe
- Place of Presentation
  Boston, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Presentation] Self-dissolving microneedle(SDMIN)for percutaneous delivery of insulin(INS)2006
- Author(s)
  K.Takada, Y.Ito, N.Sugioka, E.Hagiwara and Y.Ohashi
- Organizer
  2006 AAPS National Biotechnology Conference
- Place of Presentation
  Boston,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18310095
[Presentation] Pharmacokinetic-pharmacodynamic (PK-PD) modeling of 5-fluorouracil (5-FU) using hepatic dihydropyrimidine dehydrogenase (DPD) activity levels for myelosuppression in rats
- Author(s)
  Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Asako Nishimura, Nobuhito Shibata, and Toshiyuki Sakaeda: .
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco, California, USA,
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] Population pharmacokinetic-pharmacodynamic (PK-PD) modeling of 5-fluorouracil (5-FU) for myelosuppression in rats: predicting the whole time course of alterations of blood cell counts after the administration of various doses of 5-FU.
- Author(s)
  Yukako Ito, Shinji Kobuchi, Taro Hayakawa, Asako Nishimura, Nobuhito Shibata, and Toshiyuki Sakaeda
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco, California, USA,
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] カペシタビン反復投与時におけるカペシタビンおよび5-FUの体内動態変動
- Author(s)
  篠原康太、河渕真治、伊藤由佳子、栄田敏之
- Organizer
  第135回日本薬学会
- Place of Presentation
  熊本
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590223
[Presentation] 5-fluorouracilの体内動態に及ぼす5-fluorouracil先行急速静脈内投与の影響.
- Author(s)
  谷口真優、林明日香、河渕真治、伊藤由佳子、田村孝雄、栄田敏之
- Organizer
  第35回日本臨床薬理学会
- Place of Presentation
  愛媛
- Year and Date
  2014-12-04 – 2014-12-06
- Data Source
  KAKENHI-PROJECT-24590223

1. TAKADA Kanji (30102106)

# of Collaborated Projects: 7 results

# of Collaborated Products: 60 results
2. SHIBATA Nobuhito (60319449)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. YASUI Hiroshi (20278443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TAKEUCHI Koji (00150798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KATO Shinichi (90281500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TANAKA Akiko (30329940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Sakaeda Toshiyuki (00304098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 33 results
8. 喜里山暁子 (00234401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 上田千晶 (20247787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 齊藤卓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 河渕真治

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
12. 高橋益広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 池原譲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ito Yukako 伊藤 由佳子

ITO Yukako 伊藤 由佳子

YOSHIKAWA Yukako 吉川 由佳子

Research Projects

Research Products

Co-Researchers

Clinical feasibility of multidisciplinary treatment algorithm with circulating tumor cells for pancreatic cancerPrincipal Investigator

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Practical utility of liquid biopsy for management of pancreatic cancer chemotherapyPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Liquid biopsy for management of pancreatic cancer chemotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel systmen for predicting adverse effect of neuropathy in oxaliplatin based chemotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Novel monitoring system of fluoropyrimidines for personalized therapy based on PK/PD modeling using dihydropyrimidine dehydrogenase activity as a biomarker of predicting efficacy and side-effects.Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Microneedle skin vaccine

Principal Investigator

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Insulin microneedle DDS

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Application of carbon nanotubes to DDS carrier

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Evaluation and improvement for poor bioavailability of aminoglycosides in the intestinal tract after oral administration

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Protection against dextran sulfate sodium-induced colitis by microsheres of polyphenol (ellagic acid)

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Absorption mechanism of low bioavailability anti-cancer drug

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Enhanced Efficacy of Immunosuppressant by Modification at Molecular Level

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[Book] 実践 薬物速度論 第2版2023

Author(s)

Ito Yukako 伊藤由佳子

ITO Yukako 伊藤由佳子

YOSHIKAWA Yukako 吉川由佳子

[Book] 実践薬物速度論第2版2023