NIIMURA FUMIO 新村文男

… Alternative Names

NIIMURA Fumio 新村文男

新村文男ニイムラフミオ

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Researcher Number	30282750
Other IDs
Affiliation (Current)	2025: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2010 – 2019: 東海大学, 医学部, 准教授 2014: 東海大学, 医学部・小児科学, 准教授 2008: 東海大学, 医学部, 准教授 2003 – 2007: 東海大学, 医学部, 講師 1997 – 1998: 東京医科歯科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics Except Principal Investigator Kidney internal medicine
Keywords	Principal Investigator Nrf2 / Keap1 / 抗酸化防御機構 / 酸化ストレス / Cre-loxPシステム / conditional gene targeting / 近位尿細管 / コンディショナルターゲティング / シクロスポリン / 腎障害 … More / 急性腎障害 / 尿管結紮モデル / angiotensin receptor / proximal tubule / Cre loxP system / intrarenal renin-angiotensin system / angiotensinogen / conditional targetting / AT1受容体 / Cre loxP システム / アンジオテンシノーゲン / アンジオテンシン受容体 / Cre loxPシステム / 組織レニン・アンジオテンシン系 / アンジオテンシノーゲ / Cre-loxシステム / 水腎症 / 先天性腎尿路異常 / 間質繊維化 / 糸球体硬化 / 分子生物学 / 遺伝子解析 / スプライシング異常 / ロウ症候群 … More Except Principal Investigator 糸球体硬化症 / 慢性腎不全 / ポドサイト / Megalin / ノックアウトマウス / 糸球体上皮細胞 / トランスジェニックマウス / megalin / Angiotensin II / actinin / chronic renal failure / angiotensin / HIV-1 associated nephropathy / transgenic mice / glomerular sclerosis / podocyte / 糖尿病腎症 / アンジオテンシン / アクチニン / アンギオテンシン / HIV-1関連腎症 / AngiotensinII / 腎間質線維化 / ネフローゼ症候群 / Magalin / Angiotensinogen / AngiotensinⅡ / コンディショナル・ターゲッティング / SV40T / VEGF / Cre-loxPシステム / GIV-1 / キメラマウス / SV40 / 蛋白尿 / レニン・アンギオテンシン / 細胞周期 Less

Kidney specific local activation of Nrf2 and its effects on renal injury in micePrincipal Investigator
- Principal Investigator
  
  NIIMURA Fumio
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokai University
Effect of genetic inactivation of Keap1 on the kidney morphogenesis in micePrincipal Investigator
- Principal Investigator
  
  NIIMURA Fumio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokai University
Involvement of antioxidant defense mechanisms in the pathogenesis of renal damagePrincipal Investigator
- Principal Investigator
  
  NIIMURA Fumio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokai University
Mechanisms of progression of chronic kidney disease
- Principal Investigator
  
  MATSUSAKA Taiji
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokai University
glomerular sclerosis
- Principal Investigator
  
  ICHIKAWA Iekuni
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokai University
Functional role for intrarenal renin-angiotensin system in blood pressure control and progression of renal injuryPrincipal Investigator
- Principal Investigator
  
  NIIMURA Fumio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokai University
Study of renal diseases caused by podocyte injury
- Principal Investigator
  
  MATSUSAKA Taiji
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokai University
ロウ症候群(眼脳腎症候群)における責任遺伝子OCRL-1の異常とその生理的機能Principal Investigator
- Principal Investigator
  
  新村文男
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Medical and Dental University

All 2015 2014 2013 2012 2011 2008 2006 2005 2004

All Journal Article Presentation

[Journal Article] Unilateral ureteral obstruction attenuates intrarenal angiotensin Ⅱgeneration induced by podocyte injury.2015
- Author(s)
  Okabe M,Miyazaki Y,Niimura F,Pastan I,Nishiyama A,Yokoo T,Ichikawa I,Matsusaka T.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 308・8 Issue: 8 Pages: F932-F937
- DOI
  10.1152/ajprenal.00444.2014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22249033, KAKENHI-PROJECT-23249047, KAKENHI-PROJECT-26461241
[Journal Article] Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis.2014
- Author(s)
  Namba T, Takabatake Y, Kimura T, Takahashi A, Yamamoto T, Matsuda J, Kitamura H, Niimura F, Matsusaka T, Iwatani H, Matsui I, Kaimori J, Kioka H, Isaka Y, Rakugi H.
- Journal Title
  
  J Am Soc Nephrol.
  
  Volume: 25・10 Issue: 10 Pages: 2254-66
- DOI
  10.1681/asn.2013090986
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22249033, KAKENHI-PROJECT-24659416
[Journal Article] Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensinIIgeneration.2013
- Author(s)
  T Matsusaka,F Niimura,I Pastan ,A Shintani, A Nishiyama , I Ichikawa.
- Journal Title
  
  Kidney Int.
  
  Volume: - Issue: 5 Pages: 1068-1077
- DOI
  10.1038/ki.2013.453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249033, KAKENHI-PROJECT-23249047
[Journal Article] Foxc1 gene null mutation causes ectopic budding and kidney hypoplasia but not dysplasia.2013
- Author(s)
  Komaki F,Miyazaki Y, Niimura F,Mtsusaka T, Ichikawa I,Motojima M .
- Journal Title
  
  Cells Tissues Organs.
  
  Volume: 198・1 Issue: 1 Pages: 22-27
- DOI
  10.1159/000351291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249033, KAKENHI-PROJECT-23249047, KAKENHI-PROJECT-23591202, KAKENHI-PROJECT-25461234
[Journal Article] Liver Angiotensinogen Is the Primary Source of Renal Angiotensin2012
- Author(s)
  松阪泰二、新村文男、西山成、市川家國, 他
- Journal Title
  
  J.Am.Soc.Nephrology
  
  Volume: (in print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249033
[Journal Article] Liver angiotensinogen is the primary source of renal angiotensin II.2012
- Author(s)
  Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, Nishiyama A, Ichikawa I.
- Journal Title
  
  J Am Soc Nephrol.
  
  Volume: 23-7 Issue: 7 Pages: 1181-1189
- DOI
  10.1681/asn.2011121159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249033, KAKENHI-PROJECT-23249047
[Journal Article] Autophagy guards against cisplatin-induced acute kidney injury2012
- Author(s)
  高橋篤史,松阪泰二、新村文男, 他
- Journal Title
  
  Am J Pathol
  
  Volume: 180 Issue: 2 Pages: 517-525
- DOI
  10.1016/j.ajpath.2011.11.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249033, KAKENHI-PROJECT-22590890, KAKENHI-PROJECT-23247034, KAKENHI-PROJECT-24659416
[Journal Article] Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury2011
- Author(s)
  Kimura, T.
- Journal Title
  
  J.Am.Soc.Nephrol.
  
  Volume: 22 Issue: 5 Pages: 902-913
- DOI
  10.1681/asn.2010070705
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134007, KAKENHI-PROJECT-22249033
[Journal Article] The renin-angiotensin system in the development of the congenital anomalies of the kidney and urinary tract.2006
- Author(s)
  Niimura F, Kon V, Ichikawa I.
- Journal Title
  
  Curr Opin Pediatr. 18(2)
  
  Pages: 161-6
- Data Source
  KAKENHI-PROJECT-16109005
[Journal Article] 腎臓特異的、および肝臓特異的アンジオテンシノーゲン遺伝子不活化マウスの作製とその表現型の解析2006
- Author(s)
  新村文男
- Journal Title
  
  小児高血圧研究会誌 4巻・1号(in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591055
[Journal Article] Kidney-specific and liver-specific inactivation of angiotensinogen gene in mice2006
- Author(s)
  Fumio Niimura
- Journal Title
  
  Japanese Journal of Pediatric Hypertension Vol 4(1) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591055
[Journal Article] Permanent genetic tagging of podocytes : fate of injured podocytes in a mouse model of glomerular sclerosis.2005
- Author(s)
  Asano T, Niimura F, Pastan I, Fogo AB, Ichikawa I, Matsusaka T.
- Journal Title
  
  J Am Soc Nephrol. 16(8)
  
  Pages: 2257-2262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16109005
[Journal Article] Permanent genetic tagging of podocytes : fate of injured podocytes in a mouse model of glomerular sclerosis.2005
- Author(s)
  Asano T, Niimura F, Pastan I, Fogo AB, Ichikawa I, Matsusaka T.
- Journal Title
  
  J Am Soc Nephrol. 16(8)
  
  Pages: 2257-2262
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209030
[Presentation] Nrf2はシクロスポリンにより誘導された腎の酸化ストレスを軽減する2014
- Author(s)
  新村文男
- Organizer
  日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591585
[Presentation] Nrf2はシクロスポリンにより誘導された腎の酸化ストレスを軽減する2014
- Author(s)
  新村文男、松阪泰二、坂間隆、岡本正二郎、望月博之
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-07-06
- Data Source
  KAKENHI-PROJECT-23591585
[Presentation] Nrf2はシクロスポリンにより誘導された腎の酸化ストレスを軽減する2014
- Author(s)
  新村文男、松阪泰二
- Organizer
  日本腎臓学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-07-06
- Data Source
  KAKENHI-PROJECT-22249033
[Presentation] 脂肪細胞はアンジオテンシノーゲンの血漿濃度や血圧の維持に寄与しない2013
- Author(s)
  小泉賢洋、新村文男、深川雅史、松阪泰二
- Organizer
  日本腎臓学会総会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-22249033
[Presentation] Adipocytes do　not　significantly　contribute to plasma angiotensinogen2013
- Author(s)
  Koizumi M,Niimura F,Fukagawa M,Ichikawa I,Matsusaka T
- Organizer
  国際腎臓学会ISN　　　　　(WCN　meeting 2013)
- Place of Presentation
  Hong Kong Convention and Exhibition Center (HKCEC)
- Data Source
  KAKENHI-PROJECT-22249033
[Presentation] Autophagy Protects Kidney from Diseases through the Reduction of Mitochondrial Reactive Oxygen Species2012
- Author(s)
  Yoshitsugu Takabatake, Tomonori Kimura, Atsushi Takahashi, Tomoko Namba, Takeshi Yamamoto, Jun-Ya Kaimori, Isao Matsui, Fumio Niimura, Taiji Matsusaka,4 Hiromi Rakugi, Yoshitaka Isaka.
- Organizer
  ASN meeting 2012
- Place of Presentation
  San Diegoｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ
- Data Source
  KAKENHI-PROJECT-22249033
[Presentation] Autophagy Protects Kidney from Metabolic Stress through the Maintenance of Metabolism in Mitochondria2012
- Author(s)
  Tomonori Kimura, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba, Takeshi Yamamoto, Jun-Ya Kaimori, Isao Matsui, Fumio Niimura, Taiji Matsusaka, Hiromi Rakugi, Yoshitaka Isaka.
- Organizer
  ASN meeting 2012
- Place of Presentation
  San Diegoｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ
- Data Source
  KAKENHI-PROJECT-22249033
[Presentation] Liver-, but Not Kidney-Specific Angiotensinogen Gene Knockout Abrogates the Enhancement of Renal Angiotensin II Synthesis that Follows Podocyte Injury in Progressive Glomerulosclerosis2012
- Author(s)
  Taiji Matsusaka, Fumio Niimura, Masafumi Fukagawa, Akira Nishiyama, Iekuni Ichikawa.
- Organizer
  ASN meeting 2012
- Place of Presentation
  San Diegoｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ
- Data Source
  KAKENHI-PROJECT-22249033
[Presentation] Filtered Angiotensinogen, Not Renal Renin, Determines the Renal Angiotensin II Synthesis when Podocytes Lose Their Molecular Barrier Function.2012
- Author(s)
  Fumio Niimura, Akira Nishiyama, Iekuni Ichikawa, Taiji Matsusaka.
- Organizer
  ASN meeting 2012
- Place of Presentation
  San Diegoｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ
- Data Source
  KAKENHI-PROJECT-22249033
[Presentation] Mechanism of Increased Renal Angiotensin II in Glomerular Disease2011
- Author(s)
  Matsusaka T, Niimura F, Ichikawa I, et al
- Organizer
  ASN Kidney Week
- Place of Presentation
  Philadelphiaコンベンションセンター
- Data Source
  KAKENHI-PROJECT-22249033
[Presentation] オートファジーは近位尿細管細胞のホメオスタシスを維持する2011
- Author(s)
  新村文男、松阪泰二, 他
- Organizer
  日本腎臓学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22249033
[Presentation] Angiotensinogen Is Filtered through the Glomerulus and Reabsorbed by the Proximal Tubule in Both Mice and Humans2011
- Author(s)
  Niimura F, Matsusaka T, Ichikawa I, et al
- Organizer
  ASN Kidney Week
- Place of Presentation
  Philadelphiaコンベンションセンター
- Data Source
  KAKENHI-PROJECT-22249033
[Presentation] Augmented Expression of Renal Angiotensinogen and Intrarenal Vascular Hypertrophy in Hypotensive Mice with Liver-Specific Inactivation of Angiotensinogen.2008
- Author(s)
  Niimura F, Matsusaka T, Asano T, Ichikawa I, Nishiyama A
- Organizer
  ASN Annual Meeting2008
- Place of Presentation
  米国・フィラデルフィア
- Data Source
  KAKENHI-PROJECT-16109005
[Presentation] Augmented Expression of Renal Angiotensinogen and Intrarenal Vascular Hypertrophy in Hypotensive Mice with Liver-Specific Inactivation of Angiotensinogen.2008
- Author(s)
  Niimura F, Matsusaka T, Asano T, Ichikawa I, Nishiyama A.
- Organizer
  American Society of Nephrology Renal Week 2008 Annual Meeting
- Place of Presentation
  Philadelphia.
- Data Source
  KAKENHI-PROJECT-16109005
[Presentation] Angiotensin II Receptor (ATI) Antagonist Protects Podocytes through Mechanism (s) Independent of AT1 on Podocytes2008
- Author(s)
  Matsusaka T, Niimura F, Asano T, Fogo A, Ichikawa l
- Organizer
  ASN Annual Meeting2008
- Place of Presentation
  米国・フィラデルフィア
- Data Source
  KAKENHI-PROJECT-16109005
[Presentation] Angiotensin II Receptor (ATI) Antagonist Protects Podocytes through Mechanism(s) Independent of AT1 on Podocytes.2008
- Author(s)
  Matsusaka T, Niimura F, Asano T, Fogo A, Ichikawa I.
- Organizer
  American Society of Nephrology Renal Week 2008 Annual Meeting.
- Place of Presentation
  Philadelphia.
- Data Source
  KAKENHI-PROJECT-16109005
[Presentation] ポドサイトにおけるアンジオテンシンの役割2006
- Author(s)
  浅野貴子、市川家國、新村文男、松阪泰二.
- Organizer
  第41回日本小児腎臓病学会学術集会
- Place of Presentation
  名古屋.
- Data Source
  KAKENHI-PROJECT-16109005
[Presentation] 傷害を受けたpodocyteの運命の追跡2004
- Author(s)
  浅野貴子、松阪泰二、新村文男、市川家國.
- Organizer
  第47回日本腎臓学会学術総会
- Place of Presentation
  宇都宮.
- Data Source
  KAKENHI-PROJECT-16109005

1. MATSUSAKA Taiji (50317749)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
2. ICHIKAWA Iekuni (80317768)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
3. NAGATA Michio (10192238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MOTOJIMA Masaru (80468636)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NISHIYAMA Akira (10325334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. MOCHIZUKI Hiroyuki (50270856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. CAMPBELL Duncan J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. PASTAN Ira

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 柳田素子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NIIMURA FUMIO 新村 文男

NIIMURA Fumio 新村 文男

新村 文男 ニイムラ フミオ

Research Projects

Research Products

Co-Researchers

Kidney specific local activation of Nrf2 and its effects on renal injury in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of genetic inactivation of Keap1 on the kidney morphogenesis in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of antioxidant defense mechanisms in the pathogenesis of renal damagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of progression of chronic kidney disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

glomerular sclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional role for intrarenal renin-angiotensin system in blood pressure control and progression of renal injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of renal diseases caused by podocyte injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ロウ症候群(眼脳腎症候群)における責任遺伝子OCRL-1の異常とその生理的機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Unilateral ureteral obstruction attenuates intrarenal angiotensin Ⅱgeneration induced by podocyte injury.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensinIIgeneration.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Foxc1 gene null mutation causes ectopic budding and kidney hypoplasia but not dysplasia.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liver Angiotensinogen Is the Primary Source of Renal Angiotensin2012

Author(s)

Journal Title

Data Source

[Journal Article] Liver angiotensinogen is the primary source of renal angiotensin II.2012

Author(s)

NIIMURA FUMIO 新村文男

NIIMURA Fumio 新村文男

新村文男ニイムラフミオ

[Presentation] Adipocytes do　not　significantly　contribute to plasma angiotensinogen2013