Nakayama Toshiyuki 中山敏幸

… Alternative Names

中山敏幸ナカヤマトシユキ

NAKAYAMA Toshiyuki 中山敏幸

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Researcher Number	30284673
Other IDs
External Links
Affiliation (Current)	2023: 産業医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2021: 産業医科大学, 医学部, 教授 2008: Nagasaki University, 大学院・医歯薬学総合研究科・原研病理, 准教授 2007 – 2008: Nagasaki University, Graduate School of Biomedical Sciences, Associate Professor 2006: Nagasaki University, Graduate School of Biomedical Sciences, Atomic Bomb Disease Institute, Tumor and Diagnostic Pathology, Associate Professor, 大学院医歯薬学総合研究科, 准教授 2006: 長崎大学, 大学院医歯薬学総合研究科, 助教授 … More 2006: 長崎大学, 大学院医歯薬学総合研究科, 講師 2003 – 2005: Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 講師 2001 – 2002: 長崎大学, 医学部, 講師 1997: 長崎大, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Experimental pathology / Human pathology Except Principal Investigator Eating habits / Human pathology / Basic Section 59040:Nutrition science and health science-related / Human pathology
Keywords	Principal Investigator Tie / アンギオポエチン / Differentiation / Invasion / Angiopoietin / Colorectal cancer / 分化度 / 浸潤 / 大腸癌 / Tie-2 … More / Ang-2 / Ang-1 / GIST / TIE受容体 / TIE 受容体 / 胃腸管間質腫瘍 / MMP-9 / MMP-3 / ラット / Western Blot / ISH / MMP-1 / Antisense / 免疫染色 / 再生 / 潰瘍 / Ets-1 … More Except Principal Investigator 水素ガス / 腸内細菌 / 難消化性糖質 / 腸内細菌由来水素ガス / 発症遅延 / 重症化遅延 / BMI / H.Pylori / Ghrelin / IGF-1 / レプチン / グレリン / DOHaD / 発生・分化 / 胎仔 / 葉酸 / 腸内細菌由来代謝産物 / 生体内水素ガス分布 / 難消化吸収性糖質 / プレバイオティクス / 疾病発症遅延 / 老化 / 肝障害 / 抗酸化能 / プレバイオティックス / 疾病発症予防 / 抗酸化作用 / THRB / Non-SP cell / SP cell / Cancer stem cell / セネッセンス / 放射線抵抗性 / NF-kB / c-Ab1 / SP細胞分画 / 放射線感受性 / non-SP分画 / SP分画 / がん幹細胞 / IGF-I / Growth hormon / Appetite / Gastritis / Gastretomy / H. Pylori / ガストリン / 萎縮性胃炎 / Growth Hormone / Leptin / Gastric cancer / 胃がん / 成長ホルモン / 胃切除後症候群 Less

Effect of the hydrogen produced by the intestinal microbes in pregnant mother on the regulation of the embryonic and fetal development
- Principal Investigator
  
  中村禎子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Jumonji University
The study on the effects on the health status by the hydrogen gas produced from the fermentation of nondigestible saccharide by the intestinal microbes and its related mechanisms
- Principal Investigator
  
  NAKAMURA Sadako
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Jumonji University
Correlation among the delaying effect on the onset of diseases and hydrogen produced from intestinal microbes by intake of nondigestible saccharide
- Principal Investigator
  
  Nakamura Sadako
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Jumonji University
Expression and role of Angiopoietin family and Tie receptors in Gastrointestinal stromal tumor (GIST)Principal Investigator
- Principal Investigator
  
  NAKAYAMA Toshiyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagasaki University
Patho-physiological Analysis of Radio-resistant Cancer Stem Cells
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagasaki University
The expression of Angiopoietin and Tie receptor in colorectal cancer and its roles in proliferation and invasionPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Toshiyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
Molecular pathological analysis of the ghrelin expression in H. Pylori associated diseases.
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagasaki University
Molecular Pathological Study on the dynamics of Ghrelin in patients with gastric diseases
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagasaki University
潰瘍修復時の血管新生と再生上皮誘導に関わるEts-1転写因子の分子病態Principal Investigator
- Principal Investigator
  
  中山敏幸
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
ヒト胃癌細胞におけるEts−1前癌遺伝子発現の検討Principal Investigator
- Principal Investigator
  
  中山敏幸
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University

All 2019 2018 2017 2015 2008 2007 2006 2004 Other

All Journal Article Presentation

[Journal Article] Expression Patterns of Angiopoietin-1, -2, and Tie-2 Receptor in Ulcerative Colitis Support Involvement of the Angiopoietin/ Tie Pathway in the Progression of Ulcerative Colitis2008
- Author(s)
  Yoshizaki A, Nakayama T, Naito S, Sekine I
- Journal Title
  
  Dig Dis Sci Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590353
[Journal Article] X radiation up-regulates the occurrence and the multiplicity of invasive carcinomas in the intestinal tract of Anc(min/+) mice2007
- Author(s)
  Nakayama, T., Yamazumi, K., Uemura, T., Yoshizaki, A., Yakata, Y., Matsuu-Matsuyama, M., Shichijo, K., Sekine, I
- Journal Title
  
  Radiat Res 168(4)
  
  Pages: 433-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] X radiation up-regulates the occurrence and the multiplicity of invasive carcinomas in the intestinal tract of Apc(min/+) mice.2007
- Author(s)
  Nakayama T, et. al.
- Journal Title
  
  Radiat Res 168(4)
  
  Pages: 433-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Expression of Angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma2007
- Author(s)
  Toshiyuki Nakayama
- Journal Title
  
  World Journal of Gastroenterology (Now printing)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590351
[Journal Article] Ets-1 proto-oncogene as a potential predictor for poor prognosis of lung adenocarcinoma2007
- Author(s)
  Yamaguchi, E., Nakayama, T., Nanashima, A., Matsumoto, K., Yasutake, T., Sekine, I., Nagayasu, T
- Journal Title
  
  Tbhoku J Exp Med 213(1)
  
  Pages: 41-50
- NAID
  10019861320
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] X radiation up-regulates the occurrence and the multiplicity of invasive carcinom as in the intestinal tract of Apc(min/+)mice2007
- Author(s)
  Nakayama T, et. al.
- Journal Title
  
  Radiat Res 168(4)
  
  Pages: 433-9
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Expression of Angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma.2007
- Author(s)
  中山敏幸
- Journal Title
  
  World Journal of Gastroenterology (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590351
[Journal Article] Expression of apoptotic epithelial cells in biopsy specimens of patients with colitis2007
- Author(s)
  Shichijo, K., Shin, T., Wen, CY., Nakayama, T., Nakashima, M., Kaimovich, AG., Matsuyama, M., Sekine, I
- Journal Title
  
  Dig Dis Sci 52(9)
  
  Pages: 2037-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Expression of p-STAT3 in human gastric carcinoma : significant correlation in tumour invasion and prognosis2007
- Author(s)
  Yakata, Y., Nakayama, T., Yoshizaki, A., Kusaba, T., Inoue, K., Sekine, I
- Journal Title
  
  Int J Oncol 30(2)
  
  Pages: 437-42
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] The protective effect of interleukin-11 on the cell death induced by X-ray irradiation in cultured intestinal epithelial cell2007
- Author(s)
  Uemura, T., Nakayama, T., Kusaba, T., Yakata, Y., Yamazumi, K., Matsuu-Matsuyama, M., Shichijo, K., Sekinem, I
- Journal Title
  
  J Radiat Res 48(2)
  
  Pages: 171-7
- NAID
  110006241805
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Sucralfate protects intestinal epithelial cells from radiation-induced aproptosis in rats2006
- Author(s)
  Matsuu-Matsuyama, M., Shichijo, K., Okaichi, K., Ishii, K., Wen, CY., Fukuda, E., Nakayama, T., Nakashima, M., Okumura, Y., Sekine, I
- Journal Title
  
  J Radiat Res 47(1)
  
  Pages: 1-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Expressions of sonic hedgehog, patched, smoothened and Gli-1 in human intestinal stromal tumors and their correlation with prognosis2006
- Author(s)
  Yoshizaki, A., Nakayama, T., Naito, S., Wen, CY., Sekine, T
- Journal Title
  
  World J Gastroenterol 12(35)
  
  Pages: 5687-91
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Expression of Tie-1 and 2 receptors, and angiopoietin-1, 2 and 4 in gastric carcinoma; immunohistochemical analyses and correlation with clinicopathological factors.2004
- Author(s)
  T.Nakayama, et al.
- Journal Title
  
  Histopathology 44
  
  Pages: 232-239
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590283
[Journal Article] Expression of Tie-1 and 2 receptors, and angiopoietin-1, 2 and 4 in gastric carcinoma ; immunohistochemical analyses and correlation with clinicopathological factors.2004
- Author(s)
  T.Nakayama, et al.
- Journal Title
  
  Histopathology 44
  
  Pages: 232-239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590283
[Presentation] Effects of newly developed dietary fiber materials on gastrointestinal morphology and function by consecutive feeding in rats.2019
- Author(s)
  Nakamura S, Kintaka Y, Tanabe K, Nakayama T, Osada S, Oku T.
- Organizer
  15th International Congress of Toxicology (IUTOX ICTXV 2019).
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00876
[Presentation] 水不溶性食物繊維の継続摂取が肥満誘発モデルラットの腎機能低下遅延と腸内細菌による発酵性へ及ぼす影響．2019
- Author(s)
  中村禎子，田辺賢一，山崎優子，金高有里，山手美沙，中山敏幸，大森瑞紀，長田早苗，奥　恒行．
- Organizer
  第10回日本安定同位体・生体ガス医学応用学会．
- Data Source
  KAKENHI-PROJECT-17K00876
[Presentation] ラットにおける希少糖継続摂取による馴化が臓器・組織、血液生化学的指標ならびに肝臓P450分子種遺伝子発現へ及ぼす影響2018
- Author(s)
  山手美沙，中村禎子，田辺賢一，長田早苗，山崎優子，倉若美咲樹，中山敏幸，志村二三夫，奥恒行．
- Organizer
  平成30年度第72回日本栄養・食糧学会学術集会
- Data Source
  KAKENHI-PROJECT-17K00876
[Presentation] ラットにおける水溶性食物繊維混合微結晶セルロースの腸内細菌による発酵性と排便促進作用．2017
- Author(s)
  山手美沙, 中村禎子, 田辺賢一, 長田早苗, 金高有里, 山崎優子，端田寛子,　倉若美咲樹，中山敏幸，奥　恒行．
- Organizer
  平成29年日本食物繊維学会．
- Data Source
  KAKENHI-PROJECT-17K00876
[Presentation] 老化促進モデルマウスSAMP8における難消化性オリゴ糖の継続摂取による脳アミロイド-β沈着の遅延に関する検証．2015
- Author(s)
  田辺賢一，山口喜勇，野口紘嗣，中村禎子，中山敏幸，奥　恒行．
- Organizer
  第30回SAM研究協議会
- Place of Presentation
  じゅうろくプラザ（岐阜市，岐阜県）
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-26350128
[Presentation] 老化促進モデルマウスSAMP8における難消化性オリゴ糖摂取による腸内フローラの改善，学習・記憶障害発症遅延ならびに脳アミロイドβ沈着との関連性の検討
- Author(s)
  中村禎子，山口喜勇，田辺賢一，中山敏幸，奥　恒行．
- Organizer
  SAM研究協議会第29回研究発表会
- Place of Presentation
  東京都老人総合研究所（東京都・東京）
- Year and Date
  2014-07-05 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-26350128

1. SEKINE Ichiro (60039922)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. NAKASHIMA Masahiro (50284683)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. OHTSURU Akira (00233198)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. Nakamura Sadako (60382438)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
5. 奥恒行 (50010096)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
6. 田辺賢一 (60585727)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
7. YAMASHITA Shunichi (30200679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TAKAMURA Noboru (30295068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MITSUTAKE Norisato (50404215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 温春陽 (80346957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 森田茂樹 (00220062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大曲勝久 (90244045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 下内章人 (80211291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 金高有里 (80420909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nakayama Toshiyuki 中山 敏幸

中山 敏幸 ナカヤマ トシユキ

NAKAYAMA Toshiyuki 中山 敏幸

Research Projects

Research Products

Co-Researchers

Effect of the hydrogen produced by the intestinal microbes in pregnant mother on the regulation of the embryonic and fetal development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study on the effects on the health status by the hydrogen gas produced from the fermentation of nondigestible saccharide by the intestinal microbes and its related mechanisms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Correlation among the delaying effect on the onset of diseases and hydrogen produced from intestinal microbes by intake of nondigestible saccharide

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression and role of Angiopoietin family and Tie receptors in Gastrointestinal stromal tumor (GIST)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Patho-physiological Analysis of Radio-resistant Cancer Stem Cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The expression of Angiopoietin and Tie receptor in colorectal cancer and its roles in proliferation and invasionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathological analysis of the ghrelin expression in H. Pylori associated diseases.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Pathological Study on the dynamics of Ghrelin in patients with gastric diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

潰瘍修復時の血管新生と再生上皮誘導に関わるEts-1転写因子の分子病態Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト胃癌細胞におけるEts−1前癌遺伝子発現の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Expression Patterns of Angiopoietin-1, -2, and Tie-2 Receptor in Ulcerative Colitis Support Involvement of the Angiopoietin/ Tie Pathway in the Progression of Ulcerative Colitis2008

Author(s)

Journal Title

Data Source

[Journal Article] X radiation up-regulates the occurrence and the multiplicity of invasive carcinomas in the intestinal tract of Anc(min/+) mice2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] X radiation up-regulates the occurrence and the multiplicity of invasive carcinomas in the intestinal tract of Apc(min/+) mice.2007

Author(s)

Journal Title

Data Source

[Journal Article] Expression of Angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma2007

Nakayama Toshiyuki 中山敏幸

中山敏幸ナカヤマトシユキ

NAKAYAMA Toshiyuki 中山敏幸