Kohyama Keisuke 神山圭介

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KOUYAMA Keisuke 神山圭介

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Researcher Number	30296553
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 教授
Affiliation (based on the past Project Information) *help	2005: Keio University, School of Medicine, Assistant Prof., 医学部, 講師 2004: 慶應義塾大学, 医学部, 専任講師 1998 – 2003: 慶應義塾大学, 医学部, 講師 1999: 慶應義塾大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Neurology / Neurology Except Principal Investigator Neurology / Biological Sciences / General physiology
Keywords	Principal Investigator アルツハイマー病 / 遺伝子ターゲティング / Early pathogenetic mechanism / Gene expression profiling / Cerebrum / Amyloid precursor protein / Disease model animals / Alzheimer's disease / ノックインマウス / 差次的発現遺伝子 … More / V642I-APP変異 / 初期発症機序 / 発現遺伝子解析 / 大脳 / アミロイド前駆体蛋白 / モデル動物 / 変異ノックインマウス / 疾患モデル動物 / 疾患モデルマウス / ノックイン / Cre-loxP / V642I点変異 / APP / G蛋白β蛋白サブユニット / 神経変性疾患 … More Except Principal Investigator RAP / LRP / 神経細胞死 / アルツハイマー病 / 神経変性疾患 / Apolipoprotein E3 / α2-macroglobullin / Neuronal Death / Apolipoprotein E4 / 細胞死抑制 / ApoE3 / α2マクログロブリン / ApoE4 / cdk3 / cdk2 / 細胞周期停止 / アポトーシス / ARF / Bax / BCL6 / CR / p53 / ik3-2 / ik3-1 / ノックイン / 遺伝子ターゲティング / アミロイド前駆体蛋白 Less

A study on the early pathogenic process of Alzheimer's disease by the analysis of the aged V642I-APP knock-in mice brainPrincipal Investigator
- Principal Investigator
  
  KOUYAMA Keisuke
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Keio University
cdk2/cdk3の新しい基質ik3遺伝子群の機能解析
- Principal Investigator
  
  松岡正明
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
アルツハイマー病初期発症機序のV642I-APP変異ノックインマウスを用いた解析Principal Investigator
- Principal Investigator
  
  神山圭介
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Keio University
新規のAPP変異ノックインマウスを用いたアルツハイマー病発症関連遺伝子の探索Principal Investigator
- Principal Investigator
  
  神山圭介
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Keio University
Elucidation of the principal mechanism for dementia and identification of anti-dementia genes through the analysis of ApoE4 neurotoxicity
- Principal Investigator
  
  NISHIMOTO Ikuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Keio University
G蛋白β遺伝子標的破壊によるアルツハイマー病の神経変性機構研究Principal Investigator
- Principal Investigator
  
  神山圭介
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Keio University
神経細胞における正常及び異常アミロイド前駆体蛋白のシグナル伝達機能の解析
- Principal Investigator
  
  紅江
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Keio University
ノックインを用いた新しい遺伝子組換え戦略によるアルツハイマー病モデルマウスの開発
- Principal Investigator
  
  福田亨
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Keio University

All 2005 2004

All Journal Article

[Journal Article] A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice.2005
- Author(s)
  Tajima H, Kawasumi M, Chiba T, Yamada M, Yamashita K, Nawa M, Kita Y, Kouyama K, Aiso S, Matsuoka M, Niikura T, Nishimoto I.
- Journal Title
  
  J Neurosci Res. 79(5)
  
  Pages: 714-723
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590846
[Journal Article] Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.2004
- Author(s)
  Kawasumi M., (他10名), Kouyama K.
- Journal Title
  
  Eur J Neurosci. 19(10)
  
  Pages: 2826-2826
- Data Source
  KAKENHI-PROJECT-16590846
[Journal Article] Targeted introduction of V6421 mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.2004
- Author(s)
  Kawasumi M, (他 10 名), Kouyama K.
- Journal Title
  
  Eur J Neurosci. 19(10)
  
  Pages: 2826-2826
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590846
[Journal Article] Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.2004
- Author(s)
  Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K
- Journal Title
  
  Eur J Neurosci. 19(10)
  
  Pages: 2826-2838
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590846

1. NISHIMOTO Ikuo (80180652)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. NIIKURA Takako (10301491)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MATSUOKA Masaaki (70222297)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MATSUDA Shuji (70296721)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 紅江 (60296720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 福田亨 (20301492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMOCHI Tadanori (80306844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kohyama Keisuke 神山 圭介

KOUYAMA Keisuke 神山 圭介

Research Projects

Research Products

Co-Researchers

A study on the early pathogenic process of Alzheimer's disease by the analysis of the aged V642I-APP knock-in mice brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

cdk2/cdk3の新しい基質ik3遺伝子群の機能解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルツハイマー病初期発症機序のV642I-APP変異ノックインマウスを用いた解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規のAPP変異ノックインマウスを用いたアルツハイマー病発症関連遺伝子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the principal mechanism for dementia and identification of anti-dementia genes through the analysis of ApoE4 neurotoxicity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

G蛋白β遺伝子標的破壊によるアルツハイマー病の神経変性機構研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経細胞における正常及び異常アミロイド前駆体蛋白のシグナル伝達機能の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ノックインを用いた新しい遺伝子組換え戦略によるアルツハイマー病モデルマウスの開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.2004

Author(s)

Journal Title

Data Source

[Journal Article] Targeted introduction of V6421 mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.2004

Author(s)

Journal Title

Description

Data Source

Kohyama Keisuke 神山圭介

KOUYAMA Keisuke 神山圭介