AKIYAMA MASASHI 秋山正志

… Alternative Names

AKIYAMA Masashi 秋山正志

秋山正志アキヤママサシ

Less

Researcher Number	30298179
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2015 – 2022: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2012 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 室長 2010 – 2011: National Cardiovascular Center Research Institute, 分子病態部, 室長 2009: 国立循環器病センター研究所, 病因部, 室長 … More 2009: National Cardiovascular Center Research Institute, 病因部, 室長 2008: National Cardiovascular Center Research Institute, 病因部, 室長 1999: 早稲田大学, 人間科学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Structural biochemistry / General physiology Except Principal Investigator Hematology / Biological Sciences
Keywords	Principal Investigator ADAMTS13 / VWF / Siglec / クリアランス機構 / 結晶構造 / 好酸球 / extracellular tarp / EETosis / 血小板 / 好中球 … More / SIGLEC / プラスミノゲン / Siglecファミリー / Ashwell-Morell受容体 / LRP1 / 蛋白質 / クリアランス受容体 / プロテインS / ずり応力 / 酵素動力学 / von Willebrand因子 / エクソサイト / P475S遺伝子多型 / 分子認識及び相互作用 … More Except Principal Investigator プロテインS / 遺伝子変異 / 凝固制御因子 / 静脈血栓症 / 血栓性血小板減少性紫斑病 / ADAMTS13 / 静脈血栓塞栓症 / 血小板 / 血栓症 / フォンビルブランド因子 / 血小板凝集 / 血小板血栓 / 視交叉上核 / PACAP / 末梢時計 / 時計遺伝子 / 体内時計 / サーカディアンリズム / 変異体 / 静脈血栓症、 / 血栓性素因 / 経口避妊薬 / 日本人の血栓症 / ノックインマウス / プラスミノーゲン / 抗凝固機構 / フォンビルランド因子 / 遺伝子多型 / マウスモデル / 遺伝子 / 凝固 / 脳梗塞 / プロテアーゼ / 結晶解析 / 組み換え体 / 立体構造解析 / プロラアーゼ / ストレス / メラトニン / 8-OH DPAT / グルタミン酸 / カルモジュリン / カルシウム / NMDA / 同調 / GRP / ペプチド / 光同調 / 概日リズム / 自律神経失調症 / 交感神経系 / 協調運動 / VIP / 培養細胞 / 小脳 / 脳時計 / ホメオスターシス / 肝臓 / 大脳皮質 Less

NETosis・EETosis同時検出系を用いた特異的阻害薬の同定とin vivo効果の検証Principal Investigator
- Principal Investigator
  
  秋山正志
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Cardiovascular Center Research Institute
血小板リガンドとSiglecの相互作用による好中球・単球の血栓形成促進機構の解明Principal Investigator
- Principal Investigator
  
  秋山正志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Cardiovascular Center Research Institute
Regulation of NETs formation by VWF and ADAMTS13 binding to neutrophil SiglecsPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Masashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Cardiovascular Center Research Institute
Clearance mechanism of ADAMTS13Principal Investigator
- Principal Investigator
  
  Akiyama Masashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  National Cardiovascular Center Research Institute
Studies on thrombotic risk of protein S K196E mutation
- Principal Investigator
  
  Miyata Toshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Analysis of molecular pathogenesis of thrombosis in Japanese using mice with genetic mutations in anticoagulation/fibrinolytic factors
- Principal Investigator
  
  Banno Fumiaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Thrombotic phenotypes of two antithrombotic factors, protein S and ADAMTS13
- Principal Investigator
  
  MIYATA TOSHIYUKI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Crystal structure analysis for the pathogenesis of thrombosisPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Masashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
ADAMTS13の基質認識・切断に対する細胞外環境の効果
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
Thrombosis due to dysfunction of anticoagulant activity and strategy for prevention of thrombosis
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.Principal Investigator
- Principal Investigator
  
  AKIYAMA Masashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
体内時計階層構造システムから見た生体恒常性維持機構
- Principal Investigator
  
  柴田重信
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Waseda University
時計遺伝子発現による体内時計生理機構の解明
- Principal Investigator
  
  柴田重信
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Waseda University

[Journal Article] Siglec-5 and Siglec-14 mediate the endocytosis of ADAMTS132022
- Author(s)
  Masashi Akiyama, Yuka Eura, Koichi Kokame
- Journal Title
  
  Thrombosis Research
  
  Volume: 219 Pages: 49-59
- DOI
  10.1016/j.thromres.2022.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08468
[Journal Article] Functional regulation of von Willebrand factor ameliorates acute ischemia-reperfusion kidney injury in mice2019
- Author(s)
  Shiro Ono, Hideto Matsui, Masashi Noda, Shogo Kasuda, Noritaka Yada, Kiyomi Yoshimoto, Masashi Akiyama, Toshiyuki Miyata, Mitsuhiko Sugimoto & Kenji Nishio
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 14453-14453
- DOI
  10.1038/s41598-019-51013-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07420, KAKENHI-PROJECT-19K08829
[Journal Article] ADAMTS13 の構造変化と機能発現2019
- Author(s)
  秋山正志、小亀浩市
- Journal Title
  
  Thrombosis Medicine
  
  Volume: 9(3) Pages: 12-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08829
[Journal Article] Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI2018
- Author(s)
  Keiko Maruyama, Masashi Akiyama, Toshiyuki Miyata, Koichi Kokame
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: 2 Issue: 4 Pages: 751-756
- DOI
  10.1002/rth2.12152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-17J11206, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-16K08515
[Journal Article] von Willebrand factor aggravates hepatic ischemia-reperfusion injury by promoting neutrophil recruitment in mice2018
- Author(s)
  Urisono Y, Sakata A, Matsui H, Kasuda S, Ono S, Nishio K, Sho M, Okuchi K, Akiyama M, Miyata T, Nishimura S, Sugimoto M
- Journal Title
  
  Thromb Haemost
  
  Volume: 118 Issue: 04 Pages: 700-708
- DOI
  10.1055/s-0038-1636529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-15K10034, KAKENHI-PROJECT-15K10990, KAKENHI-PROJECT-16K08515
[Journal Article] Congenital coagulation factor X deficiency: Genetic analysis of five patients and functional characterization of mutant factor X proteins.2018
- Author(s)
  Nagaya S, Akiyama M, Murakami M, Sekiya A, Asakura H, Morishita E.
- Journal Title
  
  Haemophilia
  
  Volume: 24(5) Issue: 5 Pages: 774-785
- DOI
  10.1111/hae.13606
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07442, KAKENHI-PROJECT-18K09253, KAKENHI-PROJECT-16K11396, KAKENHI-PROJECT-16K08515
[Journal Article] Shear-induced unfolding and cleavage of VWF by ADAMTS132017
- Author(s)
  秋山正志
- Journal Title
  
  生化学
  
  Volume: 89 Issue: 3 Pages: 343-350
- DOI
  10.14952/SEIKAGAKU.2017.890343
- ISSN
  0037-1017
- Year and Date
  2017-06-25
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08515
[Journal Article] HITの発症を誘導する免役複合体の構造2016
- Author(s)
  前田琢磨, 秋山正志
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 27 Issue: 6 Pages: 678-682
- DOI
  10.2491/jjsth.27.678
- NAID
  130005250288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08515
[Journal Article] Journal Club2016
- Author(s)
  秋山正志、小亀浩市
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 27 Issue: 3 Pages: 384-385
- DOI
  10.2491/jjsth.27.384
- NAID
  130005157429
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08515
[Journal Article] Influence of ADAMTS13 deficiency on venous thrombosis in mice2015
- Author(s)
  Tashima Y, Banno F, Akiyama M, Miyata T
- Journal Title
  
  Thromb Haemost
  
  Volume: 印刷中 Issue: 07 Pages: 206-207
- DOI
  10.1160/th14-08-0656
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670454, KAKENHI-PROJECT-25860801, KAKENHI-PROJECT-25461465
[Journal Article] Influence of ADAMTS13 deficiency on venous thrombosis in mice2015
- Author(s)
  Tashima Y, Banno F, Akiyama M, Miyata T
- Journal Title
  
  Thromb Haemost
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390250
[Journal Article] 東アジア人特有のP475S変異を持つADAMTS13の立体構造と機能解析2013
- Author(s)
  秋山正志、武田壮一、宮田敏行
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 24 Pages: 613-618
- NAID
  130003393326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390250
[Journal Article] Crystal structure and enzymatic activity of an ADAMTS-13 mutant with the East Asian-specific P475S polymorphism2013
- Author(s)
  Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 11 Pages: 1399-1406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] 東アジア人特有のP475S変異を持ADAMTS13の立体構造と機能解析2013
- Author(s)
  秋山正志、武田壮一、宮田敏行
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 24 Pages: 613-618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] Crystal structure and enzymatic activity of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism.2013
- Author(s)
  Masashi Akiyama, Daisuke Nakayama, Soichi Takeda, Koichi Kokame, Junichi Takagi, and Toshiyuki Miyata.
- Journal Title
  
  J. Thromb. Haemost.
  
  Volume: (In press) Issue: 7 Pages: 1399-1406
- DOI
  10.1111/jth.12279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23570155, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060
[Journal Article] Binding of von Willebr and factor cleaving protease ADAMTS13 to Lys-plasmin(ogen)2012
- Author(s)
  Yongchol Shin, Masashi Akiyama, Toshiyuki Miyata, et al
- Journal Title
  
  Journal of Biochemistry
  
  Volume: (in press) Issue: 3 Pages: 251-25
- DOI
  10.1093/jb/mvs066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500432, KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23570155, KAKENHI-PROJECT-24390250
[Journal Article] プラスミノーゲンの立体構造2012
- Author(s)
  秋山正志、平井秀憲、宮田敏行
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 23 Pages: 516-519
- NAID
  130002077007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction.2012
- Author(s)
  Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, and Mitsuhiko Sugimoto.
- Journal Title
  
  Thromb. Haemost.
  
  Volume: 108 Issue: 12 Pages: 1236-1238
- DOI
  10.1160/th12-09-0674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-22790923, KAKENHI-PROJECT-23570155, KAKENHI-PROJECT-23659494, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-24592744
[Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction2012
- Author(s)
  Doi M, Matsui H, Takeda H, Saito Y, Takeda M, Matsunari Y, Nishio K, Shima M, Banno F, Akiyama M, Kokame K, Miyata T, Sugimoto M.
- Journal Title
  
  Thromb Haemost
  
  Volume: 108 Pages: 1236-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] ADAMTS13研究の最先端2012
- Author(s)
  宮田敏行、小亀浩市、秋山正志、坂野史明、中山大輔、武田壮一
- Journal Title
  
  臨床血液
  
  Volume: 53 Pages: 672-679
- NAID
  130004501705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] Binding of von Willebrand factor cleaving protease ADAMTS13 to Lys-plasmin(ogen)2012
- Author(s)
  Shin Y, Akiyama M, Kokame K, Soejima K, Miyata T.
- Journal Title
  
  J Biochem
  
  Volume: 152 Pages: 251-258
- NAID
  10031166136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] ADAMTS13のフォンビルブランド因子認識機構の構造学的基盤2010
- Author(s)
  秋山正志
- Journal Title
  
  日本血栓止血学会誌第21巻、第3号
  
  Pages: 319-326
- NAID
  10026400518
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] ADAMTS13のフォンビルブランド因子認識機構の構造学的基盤2010
- Author(s)
  秋山正志
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 21 Pages: 319-326
- NAID
  10026400518
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] VWF切断酵素ADAMTS13のエキソサイト認識機構2010
- Author(s)
  秋山正志
- Journal Title
  
  生化学
  
  Volume: 82 Pages: 950-956
- NAID
  10027502769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] VWF切断酵素ADAMTS13のエキソサイト認識機構2010
- Author(s)
  秋山正志
- Journal Title
  
  生化学
  
  Volume: 82 Pages: 950-956
- NAID
  10027502769
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] VWF切断酵素ADAMTS13のエキソサイト認識機構2010
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Journal Title
  
  生化学第82巻、第10号
  
  Pages: 950-956
- NAID
  10027502769
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Journal Title
  
  Acta Crystallogr Sect F Struct Biol Cryst Commun 65(Pt7)
  
  Pages: 739-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] The dorsomedial hypothalamic nucleus is not necessary for food-anticip atory circadian rhythms of behavior, temperature or clock gene expression in mice.2009
- Author(s)
  Moriya T, Aida R, Kudo T, Akiyama M, Doi M, Hayasaka N, Nakahata N, Mistlberger R, Okamura H, Shibata S
- Journal Title
  
  Eur J Neurosci 29(7)
  
  Pages: 1447-1460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Journal Title
  
  Proc Natl Acad Sci USA 106(46):
  
  Pages: 19274-19279
- NAID
  10026400518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.2009
- Author(s)
  Akiyama M
- Journal Title
  
  Acta Cryst 65
  
  Pages: 739-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057036
[Journal Article] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T.
- Journal Title
  
  Proc Natl Acad Sci USA 106
  
  Pages: 19274-19279
- NAID
  10026400518
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor2009
- Author(s)
  M. Akiyama, S. Takeda, K. Kokame, J. Takagi, T. Miyata
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 106 Issue: 46 Pages: 19274-19279
- DOI
  10.1073/pnas.0909755106
- NAID
  10026400518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von willebrand factor.2009
- Author(s)
  M.Akiyama, S.Takeda, K.Kokame, J.Takagi, T.Miyata
- Journal Title
  
  Proc Natl Acad Sci 106
  
  Pages: 19274-19279
- NAID
  10026400518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T.
- Journal Title
  
  Acta crystallogr Sect F 65
  
  Pages: 739-742
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von willebrand factor.2009
- Author(s)
  Akiyama M
- Journal Title
  
  Proc Natl Acad Sci 106
  
  Pages: 19274-19279
- NAID
  10026400518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057036
[Journal Article] Macrophage inhibitory cytokine MIC-1 is upregulated by short-wavelength light in cultured normal human dermal fibroblasts.2009
- Author(s)
  Akiyama M, Okano K, Fukada Y, Okano T.
- Journal Title
  
  FEBS Lett. 583
  
  Pages: 933-937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] ADAMTS13 P475S polymorphism causes a lowered enzymatic activity and urea lability in vitro.2008
- Author(s)
  Akiyama M
- Journal Title
  
  Thromb Haemost. 6
  
  Pages: 1830-1832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20057036
[Journal Article] ADAMTS13 P475S polymorphism causes a lowered enzymatic activity and urea lability in vitro.2008
- Author(s)
  Akiyama M, Kokame K, Miyata T.
- Journal Title
  
  J. Thromb. Haemost. 144
  
  Pages: 742-754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570120
[Patent] プロテインS K196E変異検出法2014
- Inventor(s)
  宮田敏行、秋山正志、丸山慶子、森下英理子
- Industrial Property Rights Holder
  国立循環器病研究センター、栄研化学株式会社、金沢大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-194080
- Filing Date
  2014-09-24
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] Protection of blood-brain barrier endothelial cells by the protein S-TAM receptor(s) axis2022
- Author(s)
  Teena Bhakuni、秋山正志、小亀浩市
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08468
[Presentation] プラスミノゲンのエンドサイトーシスに関わるSiglecsの同定および機能解析2022
- Author(s)
  秋山正志、小亀浩市
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08468
[Presentation] Protein S attenuates high glucose-indued damage in blood-brain barrier endothelial cells.2021
- Author(s)
  Teena Bhakuni, Masashi Akiyama, Koichi Kokame
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] ADAMTS13およびVWFのエンドサイトーシスに関わるSiglecsの機能解析2021
- Author(s)
  秋山正志、小亀浩市
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] 新規ADANTS13クリアランス受容体SIGLEC5およびSIGLEC14の機能解析2020
- Author(s)
  秋山正志、樋口（江浦）由佳、小亀浩市
- Organizer
  第42回日本血栓止血学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] 肝星細胞におけるADAMTS13の遺伝子発現調節2020
- Author(s)
  三島優一、秋山正志、小亀浩市
- Organizer
  第42回日本血栓止血学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] ADAMTS13クリアランス受容体としてのSIGLEC5の同定と機能解析2019
- Author(s)
  秋山正志、樋口（江浦）由佳、小亀浩市
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] シェディング酵素ADAMファミリープロテアーゼの成熟化とプロドメインによる活性制御の構造基盤2019
- Author(s)
  武田壮一、秋山正志、荒木聡彦、小亀浩市、James Pearson
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] Functional relevance of von Willebrand factor in mouse model of hepatic ischemia- reperfusion injury.2016
- Author(s)
  2)Yasuyuki Urisono, Hideto Matsui, Shogo Kasuda, Shiro Ono, Kenji Nishio, Masashi Akiyama, Toshiyuki Miyata, Kazuo Okuchi and Mitsuhiko Sugimoto
- Organizer
  58th ASH Annual Meeting & Exposition
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08515
[Presentation] Asymptomatic dysprothrombinemia (Prothtombin Himi) with p.M380T and p.R431H shows severely reduced clotting activity, moderate antithrombin resistance and severe thrombomodulin binding defect.2016
- Author(s)
  1)Eriko Morishita, Mao Takata, Fumina Taniguchi , Masashi Akiyama, Akiko Sekiya, Akira Takagi, Toshiyuki Miyata, and Tetsuhito Kojima
- Organizer
  58th ASH Annual Meeting & Exposition
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08515
[Presentation] マウス敗血症モデルによるvon Willebrand 因子－ADAMTS13軸の炎症制御機構2014
- Author(s)
  粕田承吾, 松井英人, 大野史郎, 西尾健治, 坂野史明, 秋山正志, 宮田敏行, 羽竹勝彦, 杉本充彦
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター（大阪市）
- Year and Date
  2014-05-31
- Data Source
  KAKENHI-PROJECT-25461465
[Presentation] ADAMTS13の正常な分泌にはシクロフィリンBによるプロリン残基異性化が必要である2013
- Author(s)
  小亀浩市、秋山正志、宮田敏行
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] 哺乳類細胞を用いたADAMTS13ドメインの一過性大量発現2013
- Author(s)
  平井秀憲、秋山正志、宮田敏行
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取市
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] 哺乳類細胞を用いたADAMTS13ドメインの一過性大量発現2013
- Author(s)
  平井秀憲, 秋山正志, 宮田敏行
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] ADAMTS13の正常な分泌にはシクロフィリンBによるプロリン残基異性化が必要である2013
- Author(s)
  小亀浩市, 秋山正志, 宮田敏行
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] マウス急性心筋梗塞モデルにおけるADAMTS13の心筋保護作用2013
- Author(s)
  土井政明, 松井英人, 竹田征治, 斎藤能彦, 武田麻衣子, 松成泰典, 西尾健治, 嶋緑倫, 坂野史明, 秋山正志, 小亀浩市, 宮田敏行, 杉本充彦
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] Protective role of ADAMTS13 for myocardium in mouse model of experimental myocardial infarction2012
- Author(s)
  Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, Mitsuhiko Sugimoto.
- Organizer
  54th American Society of Hematology, Annual Meeting and Exposition
- Place of Presentation
  Atlanta, USA.
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] ADAMTS13 improving the cell engraftment efficacy in mouse model of bone marrow transplantation2012
- Author(s)
  Hideto Matsui, Masaaki Doi, Yasunori Matsunari, Maiko Takeda, Kenji Nishio, Midori Shima, Kenji Soejima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, Mitsuhiko Sugimoto.
- Organizer
  54th American Society of Hematology, Annual Meeting and Exposition
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] シンポジウム6血栓止血学・血管生物学の最近の進歩、ADAMTS13研究の最先端2011
- Author(s)
  宮田敏行、小亀浩市、秋山正志、武田壮一、坂野史明
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-20390278
[Presentation] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.2010
- Author(s)
  秋山正志
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  鹿児島市
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.(受賞講演)2010
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] ADAMTS13非触媒ドメインの結晶構造解析とvon Willebrand因子に対する複数の非連続エキソサイトの同定2009
- Author(s)
  秋山正志
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-20057036
[Presentation] Crystal structre of the exosite-containing fragment of ADAMTS13.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi T, Miyata T
- Organizer
  XXII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  アメリカ・ボストン
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] ADAMTS13非触媒ドメインの結晶構造解析とvon Willebrand因子に対する複数の非連続エキソサイトの同定(ポスター)2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] ADAMTS13非触媒ドメインの結晶構造解析とvon Willebrand因子に対する複数の非連続エキソサイトの同定2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Identification of multiple discontinuous exosites of ADAMTS13.2009
- Author(s)
  Masashi Akiyama
- Organizer
  Gordon Research Conference, Matrix Metalloproteinases, Signalling Scissors In Development And Disease
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-20057036
[Presentation] X線解析によるADAMTS13の非触媒ドメインの構造決定とエキソサイトの同定(口演)2009
- Author(s)
  秋山正志.
- Organizer
  第7回血液・血管オルビス
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] X線解析によるADAMTS13の部分立体構造の決定とエキソサイトの同定2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第32回日本血栓止血学会学術総会
- Place of Presentation
  北九州市
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] X線解析によるADAMTS13の部分立体構造の決定とエキソサイトの同定(口演)2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第32回日本血栓止血学会学術集会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Crystal structure of the exosites-containing fragment ofADAMTS13. XXII Congress of The International Society on Thrombosis and Haemostasis.2009
- Author(s)
  Masashi Akiyama
- Organizer
  XXII Congress of The International Society on Thrombosis and Haemostasis.
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-20057036
[Presentation] Crystal structure of the exosites-containing fragment of ADAMTS13.(口演、Abstract Symposia)2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Organizer
  XXII Congress of the International Society on Thrombosis and Haemositasis
- Place of Presentation
  アメリカ・ボストン市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Identification of multiple discontinuous exosites of ADAMTS13.(ポスター)2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Organizer
  The MMP Gordon Research Conference 2009
- Place of Presentation
  スイス・Les Diableret市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Binding of ADAMTS13 with Lys-plasminogen2008
- Author(s)
  Toshiyuki MIYATA, Yongchol SHIN, Koichi KOKAME, Masashi AKIYAMA, Kenji SOEJIMA
- Organizer
  Gordon Research Conference, Hemostasis 2008
- Place of Presentation
  Waterville Valley Resort, USA
- Data Source
  KAKENHI-PROJECT-20390278
[Presentation] プロテインS K196E (PS徳島)変異特異的ELISA法の構築、Construction of ELISA system for specific detection of protein S K196E (PS Tokushima) mutation
- Author(s)
  Keiko Maruyama, Masashi Akiyama, Koichi Kokame, Eriko Morishita, Toshiyuki Miyata
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場、大阪府、大阪市
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] Structural basis for ADAMTS13 function.
- Author(s)
  Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemositasis
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] P475S型ADAMTS13タンパク質の部分立体構造決定」（ポスター）第84回日本生化学会大会
- Author(s)
  秋山正志、中山大輔、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] マウス急性心筋梗塞モデルにおけるADAMTS13の心筋保護作用
- Author(s)
  土井政明, 松井英人, 竹田征治, 斎藤能彦, 武田麻衣子, 松成泰典, 西尾健治, 嶋緑倫, 坂野史明, 秋山正志, 小亀浩市, 宮田敏行, 杉本充彦
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形国際ホテル（山形市）
- Data Source
  KAKENHI-PROJECT-25461465

1. KOKAME Koichi (40270730)

# of Collaborated Projects: 8 results

# of Collaborated Products: 40 results
2. MIYATA Toshiyuki (90183970)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
3. TAKEDA Soichi (80332279)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
4. BANNO Fumiaki (00373514)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
5. Maruyama Keiko (30712624)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 柴田重信 (10162629)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 守屋孝洋 (80298207)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OKADA Hiromi (00426503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IMOTO Hitomi (50532230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. MATSUMOTO Sachiko (80463272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KITA Toshiyuki (70589986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SAKATA Toshiyuki (80531029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OKAMOTO Akira (10531030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 海老原史樹文 (50135331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 吉松淳 (20221674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 樋口由佳 (30443477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. FAN Xinping

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SHIN Yongchol

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. EURA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. NISHIO Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 田嶌優子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 森下英理子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKIYAMA MASASHI 秋山 正志

AKIYAMA Masashi 秋山 正志

秋山 正志 アキヤマ マサシ

Research Projects

Research Products

Co-Researchers

NETosis・EETosis同時検出系を用いた特異的阻害薬の同定とin vivo効果の検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血小板リガンドとSiglecの相互作用による好中球・単球の血栓形成促進機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of NETs formation by VWF and ADAMTS13 binding to neutrophil SiglecsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clearance mechanism of ADAMTS13Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on thrombotic risk of protein S K196E mutation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of molecular pathogenesis of thrombosis in Japanese using mice with genetic mutations in anticoagulation/fibrinolytic factors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Thrombotic phenotypes of two antithrombotic factors, protein S and ADAMTS13

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crystal structure analysis for the pathogenesis of thrombosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ADAMTS13の基質認識・切断に対する細胞外環境の効果

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Thrombosis due to dysfunction of anticoagulant activity and strategy for prevention of thrombosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

体内時計階層構造システムから見た生体恒常性維持機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

時計遺伝子発現による体内時計生理機構の解明

Principal Investigator

AKIYAMA MASASHI 秋山正志

AKIYAMA Masashi 秋山正志

秋山正志アキヤママサシ