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AKIYAMA MASASHI  秋山 正志

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AKIYAMA Masashi  秋山 正志

秋山 正志  アキヤマ マサシ

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Researcher Number 30298179
Other IDs
Affiliation (Current) 2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
Affiliation (based on the past Project Information) *help 2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
2015 – 2022: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
2012 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 室長
2010 – 2011: National Cardiovascular Center Research Institute, 分子病態部, 室長
2009: 国立循環器病センター研究所, 病因部, 室長 … More
2009: National Cardiovascular Center Research Institute, 病因部, 室長
2008: National Cardiovascular Center Research Institute, 病因部, 室長
1999: 早稲田大学, 人間科学部, 助手 Less
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related / Structural biochemistry / General physiology
Except Principal Investigator
Hematology / Biological Sciences
Keywords
Principal Investigator
ADAMTS13 / VWF / Siglec / クリアランス機構 / 結晶構造 / 好酸球 / extracellular tarp / EETosis / 血小板 / 好中球 … More / SIGLEC / プラスミノゲン / Siglecファミリー / Ashwell-Morell受容体 / LRP1 / 蛋白質 / クリアランス受容体 / プロテインS / ずり応力 / 酵素動力学 / von Willebrand因子 / エクソサイト / P475S遺伝子多型 / 分子認識及び相互作用 … More
Except Principal Investigator
プロテインS / 遺伝子変異 / 凝固制御因子 / 静脈血栓症 / 血栓性血小板減少性紫斑病 / ADAMTS13 / 静脈血栓塞栓症 / 血小板 / 血栓症 / フォンビルブランド因子 / 血小板凝集 / 血小板血栓 / 視交叉上核 / PACAP / 末梢時計 / 時計遺伝子 / 体内時計 / サーカディアンリズム / 変異体 / 静脈血栓症、 / 血栓性素因 / 経口避妊薬 / 日本人の血栓症 / ノックインマウス / プラスミノーゲン / 抗凝固機構 / フォンビルランド因子 / 遺伝子多型 / マウスモデル / 遺伝子 / 凝固 / 脳梗塞 / プロテアーゼ / 結晶解析 / 組み換え体 / 立体構造解析 / プロラアーゼ / ストレス / メラトニン / 8-OH DPAT / グルタミン酸 / カルモジュリン / カルシウム / NMDA / 同調 / GRP / ペプチド / 光同調 / 概日リズム / 自律神経失調症 / 交感神経系 / 協調運動 / VIP / 培養細胞 / 小脳 / 脳時計 / ホメオスターシス / 肝臓 / 大脳皮質 Less
  • Research Projects

    (13 results)
  • Research Products

    (76 results)
  • Co-Researchers

    (22 People)
  •  NETosis・EETosis同時検出系を用いた特異的阻害薬の同定とin vivo効果の検証Principal Investigator

    • Principal Investigator
      秋山 正志
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  血小板リガンドとSiglecの相互作用による好中球・単球の血栓形成促進機構の解明Principal Investigator

    • Principal Investigator
      秋山 正志
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Regulation of NETs formation by VWF and ADAMTS13 binding to neutrophil SiglecsPrincipal Investigator

    • Principal Investigator
      AKIYAMA Masashi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Clearance mechanism of ADAMTS13Principal Investigator

    • Principal Investigator
      Akiyama Masashi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Studies on thrombotic risk of protein S K196E mutation

    • Principal Investigator
      Miyata Toshiyuki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Analysis of molecular pathogenesis of thrombosis in Japanese using mice with genetic mutations in anticoagulation/fibrinolytic factors

    • Principal Investigator
      Banno Fumiaki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Thrombotic phenotypes of two antithrombotic factors, protein S and ADAMTS13

    • Principal Investigator
      MIYATA TOSHIYUKI
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Crystal structure analysis for the pathogenesis of thrombosisPrincipal Investigator

    • Principal Investigator
      AKIYAMA Masashi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  ADAMTS13の基質認識・切断に対する細胞外環境の効果

    • Principal Investigator
      MIYATA Toshiyuki
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Thrombosis due to dysfunction of anticoagulant activity and strategy for prevention of thrombosis

    • Principal Investigator
      MIYATA Toshiyuki
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.Principal Investigator

    • Principal Investigator
      AKIYAMA Masashi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  体内時計階層構造システムから見た生体恒常性維持機構

    • Principal Investigator
      柴田 重信
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Waseda University
  •  時計遺伝子発現による体内時計生理機構の解明

    • Principal Investigator
      柴田 重信
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Waseda University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Patent

  • [Journal Article] Siglec-5 and Siglec-14 mediate the endocytosis of ADAMTS132022

    • Author(s)
      Masashi Akiyama, Yuka Eura, Koichi Kokame
    • Journal Title

      Thrombosis Research

      Volume: 219 Pages: 49-59

    • DOI

      10.1016/j.thromres.2022.09.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K08468
  • [Journal Article] Functional regulation of von Willebrand factor ameliorates acute ischemia-reperfusion kidney injury in mice2019

    • Author(s)
      Shiro Ono, Hideto Matsui, Masashi Noda, Shogo Kasuda, Noritaka Yada, Kiyomi Yoshimoto, Masashi Akiyama, Toshiyuki Miyata, Mitsuhiko Sugimoto & Kenji Nishio
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 14453-14453

    • DOI

      10.1038/s41598-019-51013-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07420, KAKENHI-PROJECT-19K08829
  • [Journal Article] ADAMTS13 の構造変化と機能発現2019

    • Author(s)
      秋山正志、小亀浩市
    • Journal Title

      Thrombosis Medicine

      Volume: 9(3) Pages: 12-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08829
  • [Journal Article] Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI2018

    • Author(s)
      Keiko Maruyama, Masashi Akiyama, Toshiyuki Miyata, Koichi Kokame
    • Journal Title

      Research and Practice in Thrombosis and Haemostasis

      Volume: 2 Issue: 4 Pages: 751-756

    • DOI

      10.1002/rth2.12152

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-17J11206, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-16K08515
  • [Journal Article] von Willebrand factor aggravates hepatic ischemia-reperfusion injury by promoting neutrophil recruitment in mice2018

    • Author(s)
      Urisono Y, Sakata A, Matsui H, Kasuda S, Ono S, Nishio K, Sho M, Okuchi K, Akiyama M, Miyata T, Nishimura S, Sugimoto M
    • Journal Title

      Thromb Haemost

      Volume: 118 Issue: 04 Pages: 700-708

    • DOI

      10.1055/s-0038-1636529

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-15K10034, KAKENHI-PROJECT-15K10990, KAKENHI-PROJECT-16K08515
  • [Journal Article] Congenital coagulation factor X deficiency: Genetic analysis of five patients and functional characterization of mutant factor X proteins.2018

    • Author(s)
      Nagaya S, Akiyama M, Murakami M, Sekiya A, Asakura H, Morishita E.
    • Journal Title

      Haemophilia

      Volume: 24(5) Issue: 5 Pages: 774-785

    • DOI

      10.1111/hae.13606

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07442, KAKENHI-PROJECT-18K09253, KAKENHI-PROJECT-16K11396, KAKENHI-PROJECT-16K08515
  • [Journal Article] Shear-induced unfolding and cleavage of VWF by ADAMTS132017

    • Author(s)
      秋山正志
    • Journal Title

      生化学

      Volume: 89 Issue: 3 Pages: 343-350

    • DOI

      10.14952/SEIKAGAKU.2017.890343

    • ISSN
      0037-1017
    • Year and Date
      2017-06-25
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08515
  • [Journal Article] HITの発症を誘導する免役複合体の構造2016

    • Author(s)
      前田琢磨, 秋山正志
    • Journal Title

      日本血栓止血学会誌

      Volume: 27 Issue: 6 Pages: 678-682

    • DOI

      10.2491/jjsth.27.678

    • NAID

      130005250288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08515
  • [Journal Article] Journal Club2016

    • Author(s)
      秋山正志、小亀浩市
    • Journal Title

      Japanese Journal of Thrombosis and Hemostasis

      Volume: 27 Issue: 3 Pages: 384-385

    • DOI

      10.2491/jjsth.27.384

    • NAID

      130005157429

    • ISSN
      0915-7441, 1880-8808
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08515
  • [Journal Article] Influence of ADAMTS13 deficiency on venous thrombosis in mice2015

    • Author(s)
      Tashima Y, Banno F, Akiyama M, Miyata T
    • Journal Title

      Thromb Haemost

      Volume: 印刷中 Issue: 07 Pages: 206-207

    • DOI

      10.1160/th14-08-0656

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25670454, KAKENHI-PROJECT-25860801, KAKENHI-PROJECT-25461465
  • [Journal Article] Influence of ADAMTS13 deficiency on venous thrombosis in mice2015

    • Author(s)
      Tashima Y, Banno F, Akiyama M, Miyata T
    • Journal Title

      Thromb Haemost

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390250
  • [Journal Article] 東アジア人特有のP475S変異を持つADAMTS13の立体構造と機能解析2013

    • Author(s)
      秋山正志、武田壮一、宮田敏行
    • Journal Title

      日本血栓止血学会誌

      Volume: 24 Pages: 613-618

    • NAID

      130003393326

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390250
  • [Journal Article] Crystal structure and enzymatic activity of an ADAMTS-13 mutant with the East Asian-specific P475S polymorphism2013

    • Author(s)
      Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T.
    • Journal Title

      J Thromb Haemost

      Volume: 11 Pages: 1399-1406

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Journal Article] 東アジア人特有のP475S変異を持ADAMTS13の立体構造と機能解析2013

    • Author(s)
      秋山正志、武田壮一、宮田敏行
    • Journal Title

      日本血栓止血学会誌

      Volume: 24 Pages: 613-618

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Journal Article] Crystal structure and enzymatic activity of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism.2013

    • Author(s)
      Masashi Akiyama, Daisuke Nakayama, Soichi Takeda, Koichi Kokame, Junichi Takagi, and Toshiyuki Miyata.
    • Journal Title

      J. Thromb. Haemost.

      Volume: (In press) Issue: 7 Pages: 1399-1406

    • DOI

      10.1111/jth.12279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23570155, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060
  • [Journal Article] Binding of von Willebr and factor cleaving protease ADAMTS13 to Lys-plasmin(ogen)2012

    • Author(s)
      Yongchol Shin, Masashi Akiyama, Toshiyuki Miyata, et al
    • Journal Title

      Journal of Biochemistry

      Volume: (in press) Issue: 3 Pages: 251-25

    • DOI

      10.1093/jb/mvs066

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500432, KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23570155, KAKENHI-PROJECT-24390250
  • [Journal Article] プラスミノーゲンの立体構造2012

    • Author(s)
      秋山正志、平井秀憲、宮田敏行
    • Journal Title

      日本血栓止血学会誌

      Volume: 23 Pages: 516-519

    • NAID

      130002077007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction.2012

    • Author(s)
      Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, and Mitsuhiko Sugimoto.
    • Journal Title

      Thromb. Haemost.

      Volume: 108 Issue: 12 Pages: 1236-1238

    • DOI

      10.1160/th12-09-0674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-22790923, KAKENHI-PROJECT-23570155, KAKENHI-PROJECT-23659494, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-24592744
  • [Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction2012

    • Author(s)
      Doi M, Matsui H, Takeda H, Saito Y, Takeda M, Matsunari Y, Nishio K, Shima M, Banno F, Akiyama M, Kokame K, Miyata T, Sugimoto M.
    • Journal Title

      Thromb Haemost

      Volume: 108 Pages: 1236-1238

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Journal Article] ADAMTS13研究の最先端2012

    • Author(s)
      宮田敏行、小亀浩市、秋山正志、坂野史明、中山大輔、武田壮一
    • Journal Title

      臨床血液

      Volume: 53 Pages: 672-679

    • NAID

      130004501705

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Journal Article] Binding of von Willebrand factor cleaving protease ADAMTS13 to Lys-plasmin(ogen)2012

    • Author(s)
      Shin Y, Akiyama M, Kokame K, Soejima K, Miyata T.
    • Journal Title

      J Biochem

      Volume: 152 Pages: 251-258

    • NAID

      10031166136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Journal Article] ADAMTS13のフォンビルブランド因子認識機構の構造学的基盤2010

    • Author(s)
      秋山正志
    • Journal Title

      日本血栓止血学会誌 第21巻、第3号

      Pages: 319-326

    • NAID

      10026400518

    • Data Source
      KAKENHI-PROJECT-20570120
  • [Journal Article] ADAMTS13のフォンビルブランド因子認識機構の構造学的基盤2010

    • Author(s)
      秋山正志
    • Journal Title

      日本血栓止血学会誌

      Volume: 21 Pages: 319-326

    • NAID

      10026400518

    • Data Source
      KAKENHI-PROJECT-20570120
  • [Journal Article] VWF切断酵素ADAMTS13のエキソサイト認識機構2010

    • Author(s)
      秋山正志
    • Journal Title

      生化学

      Volume: 82 Pages: 950-956

    • NAID

      10027502769

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390278
  • [Journal Article] VWF切断酵素ADAMTS13のエキソサイト認識機構2010

    • Author(s)
      秋山正志
    • Journal Title

      生化学

      Volume: 82 Pages: 950-956

    • NAID

      10027502769

    • Data Source
      KAKENHI-PROJECT-20570120
  • [Journal Article] VWF切断酵素ADAMTS13のエキソサイト認識機構2010

    • Author(s)
      秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
    • Journal Title

      生化学 第82巻、第10号

      Pages: 950-956

    • NAID

      10027502769

    • Data Source
      KAKENHI-PROJECT-20570120
  • [Journal Article] Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.2009

    • Author(s)
      Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun 65(Pt7)

      Pages: 739-742

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Journal Article] The dorsomedial hypothalamic nucleus is not necessary for food-anticip atory circadian rhythms of behavior, temperature or clock gene expression in mice.2009

    • Author(s)
      Moriya T, Aida R, Kudo T, Akiyama M, Doi M, Hayasaka N, Nakahata N, Mistlberger R, Okamura H, Shibata S
    • Journal Title

      Eur J Neurosci 29(7)

      Pages: 1447-1460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Journal Article] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.2009

    • Author(s)
      Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
    • Journal Title

      Proc Natl Acad Sci USA 106(46):

      Pages: 19274-19279

    • NAID

      10026400518

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Journal Article] Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.2009

    • Author(s)
      Akiyama M
    • Journal Title

      Acta Cryst 65

      Pages: 739-742

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057036
  • [Journal Article] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.2009

    • Author(s)
      Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T.
    • Journal Title

      Proc Natl Acad Sci USA 106

      Pages: 19274-19279

    • NAID

      10026400518

    • Data Source
      KAKENHI-PROJECT-20570120
  • [Journal Article] Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor2009

    • Author(s)
      M. Akiyama, S. Takeda, K. Kokame, J. Takagi, T. Miyata
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 106 Issue: 46 Pages: 19274-19279

    • DOI

      10.1073/pnas.0909755106

    • NAID

      10026400518

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390278
  • [Journal Article] Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von willebrand factor.2009

    • Author(s)
      M.Akiyama, S.Takeda, K.Kokame, J.Takagi, T.Miyata
    • Journal Title

      Proc Natl Acad Sci 106

      Pages: 19274-19279

    • NAID

      10026400518

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390278
  • [Journal Article] Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.2009

    • Author(s)
      Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T.
    • Journal Title

      Acta crystallogr Sect F 65

      Pages: 739-742

    • Data Source
      KAKENHI-PROJECT-20570120
  • [Journal Article] Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von willebrand factor.2009

    • Author(s)
      Akiyama M
    • Journal Title

      Proc Natl Acad Sci 106

      Pages: 19274-19279

    • NAID

      10026400518

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057036
  • [Journal Article] Macrophage inhibitory cytokine MIC-1 is upregulated by short-wavelength light in cultured normal human dermal fibroblasts.2009

    • Author(s)
      Akiyama M, Okano K, Fukada Y, Okano T.
    • Journal Title

      FEBS Lett. 583

      Pages: 933-937

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Journal Article] ADAMTS13 P475S polymorphism causes a lowered enzymatic activity and urea lability in vitro.2008

    • Author(s)
      Akiyama M
    • Journal Title

      Thromb Haemost. 6

      Pages: 1830-1832

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20057036
  • [Journal Article] ADAMTS13 P475S polymorphism causes a lowered enzymatic activity and urea lability in vitro.2008

    • Author(s)
      Akiyama M, Kokame K, Miyata T.
    • Journal Title

      J. Thromb. Haemost. 144

      Pages: 742-754

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Patent] プロテインS K196E変異検出法2014

    • Inventor(s)
      宮田敏行、秋山正志、丸山慶子、森下英理子
    • Industrial Property Rights Holder
      国立循環器病研究センター、栄研化学株式会社、金沢大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-194080
    • Filing Date
      2014-09-24
    • Data Source
      KAKENHI-PROJECT-24390250
  • [Presentation] Protection of blood-brain barrier endothelial cells by the protein S-TAM receptor(s) axis2022

    • Author(s)
      Teena Bhakuni、秋山正志、小亀浩市
    • Organizer
      第44回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K08468
  • [Presentation] プラスミノゲンのエンドサイトーシスに関わるSiglecsの同定および機能解析2022

    • Author(s)
      秋山正志、小亀浩市
    • Organizer
      第44回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K08468
  • [Presentation] Protein S attenuates high glucose-indued damage in blood-brain barrier endothelial cells.2021

    • Author(s)
      Teena Bhakuni, Masashi Akiyama, Koichi Kokame
    • Organizer
      第43回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08829
  • [Presentation] ADAMTS13およびVWFのエンドサイトーシスに関わるSiglecsの機能解析2021

    • Author(s)
      秋山正志、小亀浩市
    • Organizer
      第43回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08829
  • [Presentation] 新規ADANTS13クリアランス受容体SIGLEC5およびSIGLEC14の機能解析2020

    • Author(s)
      秋山正志、樋口(江浦)由佳、小亀浩市
    • Organizer
      第42回日本血栓止血学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K08829
  • [Presentation] 肝星細胞におけるADAMTS13の遺伝子発現調節2020

    • Author(s)
      三島優一、秋山正志、小亀浩市
    • Organizer
      第42回日本血栓止血学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K08829
  • [Presentation] ADAMTS13クリアランス受容体としてのSIGLEC5の同定と機能解析2019

    • Author(s)
      秋山正志、樋口(江浦)由佳、小亀浩市
    • Organizer
      第41回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08829
  • [Presentation] シェディング酵素ADAMファミリープロテアーゼの成熟化とプロドメインによる活性制御の構造基盤2019

    • Author(s)
      武田壮一、秋山正志、荒木聡彦、小亀浩市、James Pearson
    • Organizer
      第41回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08829
  • [Presentation] Functional relevance of von Willebrand factor in mouse model of hepatic ischemia- reperfusion injury.2016

    • Author(s)
      2)Yasuyuki Urisono, Hideto Matsui, Shogo Kasuda, Shiro Ono, Kenji Nishio, Masashi Akiyama, Toshiyuki Miyata, Kazuo Okuchi and Mitsuhiko Sugimoto
    • Organizer
      58th ASH Annual Meeting & Exposition
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08515
  • [Presentation] Asymptomatic dysprothrombinemia (Prothtombin Himi) with p.M380T and p.R431H shows severely reduced clotting activity, moderate antithrombin resistance and severe thrombomodulin binding defect.2016

    • Author(s)
      1)Eriko Morishita, Mao Takata, Fumina Taniguchi , Masashi Akiyama, Akiko Sekiya, Akira Takagi, Toshiyuki Miyata, and Tetsuhito Kojima
    • Organizer
      58th ASH Annual Meeting & Exposition
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08515
  • [Presentation] マウス敗血症モデルによるvon Willebrand 因子-ADAMTS13軸の炎症制御機構2014

    • Author(s)
      粕田承吾, 松井英人, 大野史郎, 西尾健治, 坂野史明, 秋山正志, 宮田敏行, 羽竹勝彦, 杉本充彦
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪国際交流センター(大阪市)
    • Year and Date
      2014-05-31
    • Data Source
      KAKENHI-PROJECT-25461465
  • [Presentation] ADAMTS13の正常な分泌にはシクロフィリンBによるプロリン残基異性化が必要である2013

    • Author(s)
      小亀浩市、秋山正志、宮田敏行
    • Organizer
      第35回日本血栓止血学会学術集会
    • Place of Presentation
      山形市
    • Data Source
      KAKENHI-PROJECT-24390250
  • [Presentation] 哺乳類細胞を用いたADAMTS13ドメインの一過性大量発現2013

    • Author(s)
      平井秀憲、秋山正志、宮田敏行
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      鳥取市
    • Data Source
      KAKENHI-PROJECT-24390250
  • [Presentation] 哺乳類細胞を用いたADAMTS13ドメインの一過性大量発現2013

    • Author(s)
      平井秀憲, 秋山正志, 宮田敏行
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      鳥取市
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Presentation] ADAMTS13の正常な分泌にはシクロフィリンBによるプロリン残基異性化が必要である2013

    • Author(s)
      小亀浩市, 秋山正志, 宮田敏行
    • Organizer
      第35回日本血栓止血学会学術集会
    • Place of Presentation
      山形市
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Presentation] マウス急性心筋梗塞モデルにおけるADAMTS13の心筋保護作用2013

    • Author(s)
      土井政明, 松井英人, 竹田征治, 斎藤能彦, 武田麻衣子, 松成泰典, 西尾健治, 嶋緑倫, 坂野史明, 秋山正志, 小亀浩市, 宮田敏行, 杉本充彦
    • Organizer
      第35回日本血栓止血学会学術集会
    • Place of Presentation
      山形市
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Presentation] Protective role of ADAMTS13 for myocardium in mouse model of experimental myocardial infarction2012

    • Author(s)
      Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, Mitsuhiko Sugimoto.
    • Organizer
      54th American Society of Hematology, Annual Meeting and Exposition
    • Place of Presentation
      Atlanta, USA.
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Presentation] ADAMTS13 improving the cell engraftment efficacy in mouse model of bone marrow transplantation2012

    • Author(s)
      Hideto Matsui, Masaaki Doi, Yasunori Matsunari, Maiko Takeda, Kenji Nishio, Midori Shima, Kenji Soejima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, Mitsuhiko Sugimoto.
    • Organizer
      54th American Society of Hematology, Annual Meeting and Exposition
    • Place of Presentation
      Atlanta, USA
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Presentation] シンポジウム6血栓止血学・血管生物学の最近の進歩、ADAMTS13研究の最先端2011

    • Author(s)
      宮田敏行、小亀浩市、秋山正志、武田壮一、坂野史明
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋市
    • Data Source
      KAKENHI-PROJECT-20390278
  • [Presentation] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.2010

    • Author(s)
      秋山正志
    • Organizer
      第33回日本血栓止血学会学術集会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2010-04-22
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Presentation] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.(受賞講演)2010

    • Author(s)
      秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
    • Organizer
      第33回日本血栓止血学会学術集会
    • Place of Presentation
      鹿児島市
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Presentation] ADAMTS13非触媒ドメインの結晶構造解析とvon Willebrand因子に対する複数の非連続エキソサイトの同定2009

    • Author(s)
      秋山正志
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-20057036
  • [Presentation] Crystal structre of the exosite-containing fragment of ADAMTS13.2009

    • Author(s)
      Akiyama M, Takeda S, Kokame K, Takagi T, Miyata T
    • Organizer
      XXII Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      アメリカ・ボストン
    • Year and Date
      2009-07-13
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Presentation] ADAMTS13非触媒ドメインの結晶構造解析とvon Willebrand因子に対する複数の非連続エキソサイトの同定(ポスター)2009

    • Author(s)
      秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Presentation] ADAMTS13非触媒ドメインの結晶構造解析とvon Willebrand因子に対する複数の非連続エキソサイトの同定2009

    • Author(s)
      秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
    • Organizer
      第82回 日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Presentation] Identification of multiple discontinuous exosites of ADAMTS13.2009

    • Author(s)
      Masashi Akiyama
    • Organizer
      Gordon Research Conference, Matrix Metalloproteinases, Signalling Scissors In Development And Disease
    • Place of Presentation
      Les Diablerets, Switzerland
    • Data Source
      KAKENHI-PROJECT-20057036
  • [Presentation] X線解析によるADAMTS13の非触媒ドメインの構造決定とエキソサイトの同定(口演)2009

    • Author(s)
      秋山正志.
    • Organizer
      第7回血液・血管オルビス
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Presentation] X線解析によるADAMTS13の部分立体構造の決定とエキソサイトの同定2009

    • Author(s)
      秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
    • Organizer
      第32回 日本血栓止血学会学術総会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Presentation] X線解析によるADAMTS13の部分立体構造の決定とエキソサイトの同定(口演)2009

    • Author(s)
      秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
    • Organizer
      第32回日本血栓止血学会学術集会
    • Place of Presentation
      北九州市
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Presentation] Crystal structure of the exosites-containing fragment ofADAMTS13. XXII Congress of The International Society on Thrombosis and Haemostasis.2009

    • Author(s)
      Masashi Akiyama
    • Organizer
      XXII Congress of The International Society on Thrombosis and Haemostasis.
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-20057036
  • [Presentation] Crystal structure of the exosites-containing fragment of ADAMTS13.(口演、Abstract Symposia)2009

    • Author(s)
      Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
    • Organizer
      XXII Congress of the International Society on Thrombosis and Haemositasis
    • Place of Presentation
      アメリカ・ボストン市
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Presentation] Identification of multiple discontinuous exosites of ADAMTS13.(ポスター)2009

    • Author(s)
      Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
    • Organizer
      The MMP Gordon Research Conference 2009
    • Place of Presentation
      スイス・Les Diableret市
    • Data Source
      KAKENHI-PROJECT-20570120
  • [Presentation] Binding of ADAMTS13 with Lys-plasminogen2008

    • Author(s)
      Toshiyuki MIYATA, Yongchol SHIN, Koichi KOKAME, Masashi AKIYAMA, Kenji SOEJIMA
    • Organizer
      Gordon Research Conference, Hemostasis 2008
    • Place of Presentation
      Waterville Valley Resort, USA
    • Data Source
      KAKENHI-PROJECT-20390278
  • [Presentation] プロテインS K196E (PS徳島)変異特異的ELISA法の構築、Construction of ELISA system for specific detection of protein S K196E (PS Tokushima) mutation

    • Author(s)
      Keiko Maruyama, Masashi Akiyama, Koichi Kokame, Eriko Morishita, Toshiyuki Miyata
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪府、大阪市
    • Year and Date
      2014-10-31 – 2014-11-02
    • Data Source
      KAKENHI-PROJECT-24390250
  • [Presentation] Structural basis for ADAMTS13 function.

    • Author(s)
      Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T
    • Organizer
      XXIII Congress of the International Society on Thrombosis and Haemositasis
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Presentation] P475S型ADAMTS13タンパク質の部分立体構造決定」(ポスター)第84回日本生化学会大会

    • Author(s)
      秋山正志、中山大輔、武田壮一、小亀浩市、高木淳一、宮田敏行
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-23570155
  • [Presentation] マウス急性心筋梗塞モデルにおけるADAMTS13の心筋保護作用

    • Author(s)
      土井政明, 松井英人, 竹田征治, 斎藤能彦, 武田麻衣子, 松成泰典, 西尾健治, 嶋緑倫, 坂野史明, 秋山正志, 小亀浩市, 宮田敏行, 杉本充彦
    • Organizer
      第35回日本血栓止血学会学術集会
    • Place of Presentation
      山形国際ホテル(山形市)
    • Data Source
      KAKENHI-PROJECT-25461465
  • 1.  KOKAME Koichi (40270730)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 40 results
  • 2.  MIYATA Toshiyuki (90183970)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 13 results
  • 3.  TAKEDA Soichi (80332279)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 22 results
  • 4.  BANNO Fumiaki (00373514)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 5.  Maruyama Keiko (30712624)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  柴田 重信 (10162629)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  守屋 孝洋 (80298207)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  OKADA Hiromi (00426503)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  IMOTO Hitomi (50532230)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  MATSUMOTO Sachiko (80463272)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KITA Toshiyuki (70589986)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SAKATA Toshiyuki (80531029)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  OKAMOTO Akira (10531030)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  海老原 史樹文 (50135331)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  吉松 淳 (20221674)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  樋口 由佳 (30443477)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  FAN Xinping
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  SHIN Yongchol
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  EURA Yuka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  NISHIO Kenji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  田嶌 優子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  森下 英理子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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