Kinoshita Noriyuki 木下典行

… Alternative Names

木下典行キノシタノリユキ

KINOSHITA Noriyuki 木下典行

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Researcher Number	30300940
Other IDs
Affiliation (Current)	2025: 基礎生物学研究所, 初期発生研究部門, 准教授
Affiliation (based on the past Project Information) *help	2025: 基礎生物学研究所, 初期発生研究部門, 准教授 2021 – 2023: 基礎生物学研究所, 初期発生研究部門, 准教授 2020 – 2021: 基礎生物学研究所, 形態形成研究部門, 准教授 2006 – 2013: 基礎生物学研究所, 形態形成研究部門, 准教授 2004 – 2005: 基礎生物学研究所, 形態形成研究部門, 助教授 … More 2000 – 2001: (財)東京都医学研究機構, 東京都神経科学総合研究所・分子神経生理学研究部門, 主任研究員 1999: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 主任研究員 1998: (財)東京都神経科学総合研究所, 神経生理学研究部門, 主任研究員 Less
Review Section/Research Field	Principal Investigator Developmental biology / Basic Section 44020:Developmental biology-related / Biological Sciences / Biological Sciences / Developmental biology Except Principal Investigator Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Basic Section 44020:Developmental biology-related / Developmental biology / Developmental biology
Keywords	Principal Investigator 原腸形成 / アフリカツメガエル / 細胞接着 / Wntシグナル / ユビキチン / gastrulation / 初期発生 / プロテイン・キナーゼ / 力学応答 / タイトジャンクション … More / タンパク質リン酸化 / ZO-1 / 密着結合 / 初期胚 / プロテインキナーゼ / 上皮細胞 / 子宮 / マウス / ERK / 力学刺激 / アフリカツメガエル胚 / Wnt signaling / membrane trafficking / 膜輸送 / ubiquitin / Wnt signaling pathway / Xenopus / アクチン細胞骨格 / 細胞接着分子 / ユビキチン化 / 細胞運動 / 中胚葉 / 神経 / 発生 / GTP結合タンパク質 / 神経誘導 … More Except Principal Investigator 細胞間接着 / prickle / 原腸形成 / PKC / Wnt / アフリカツメガエル / ttv / EXT / HSPG / 着床 / 子宮 / 液-液相分離 / 液‐液相分離 / 力学刺激 / ZO-1 / spina bifida / Xenopus laevis / Archenteron formation / cell polarity / ゲノム / 遺伝子機能 / 遺伝子発現 / 細胞間相互作用 / 進化 / 再生 / 器官形成 / 初期発生 / 二分脊椎症 / 細胞極性 / Xenopus / Morphogen / Drosophila / brinker / Dpp / engrailed / EGF / FLP-FRT / Xvent2 / brk / mtv / dpp / SNP / 形態形成 / モルフォゲン / ショウジョウバエ Less

マウス胚着床における胚ー子宮相互作用を起点とした子宮上皮の組織形態変化の制御機構Principal Investigator
- Principal Investigator
  
  木下典行
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  National Institute for Basic Biology
上皮細胞が頂端面で力学的に”連結”する機構の解明
- Principal Investigator
  
  藤森俊彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  National Institute for Basic Biology
Force-dependent control of cell-to-cell adhesion through the regulation of ZO-1 phase separation
- Principal Investigator
  
  上野直人
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  National Institutes of Natural Sciences
Mechanically activated protein kinases regulate mesenchymal-epithelial transition-like reaction in early embryonic ectodermPrincipal Investigator
- Principal Investigator
  
  Kinoshita Noriyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  National Institute for Basic Biology
Ｗｎｔシグナルは細胞間接着の調節を通して脊索形成での細胞運動を制御するPrincipal Investigator
- Principal Investigator
  
  木下典行
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Basic Biology
The regulation of cell movement by the ubiquitin system.Principal Investigator
- Principal Investigator
  
  KINOSHITA Noriyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  National Institute for Basic Biology
Role of ubiquitin system in Xenopus gastrulation movementsPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Noriyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  National Institute for Basic Biology
原腸形成過程においてWntシグナルが制御する新規ユビキチン化・分解経路Principal Investigator
- Principal Investigator
  
  木下典行
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Basic Biology
Role of membrane trafficking in Wnt signaling that regulates gastrulationPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Noriyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  National Institute for Basic Biology
Clarification of cell polarity formation mechanism in archenteron formation
- Principal Investigator
  
  UENO Naoto
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Developmental biology
- Research Institution
  National Institute for Basic Biology
Molecular and cellular analyses of the Wnt signaling pathway that regulates Xenopus gastrulationPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Noriyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  National Institute for Basic Biology
Identification of novel patterning genes in Drosophila development
- Principal Investigator
  
  TABATA Tetsuya
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  The University of tokyo
カエル初期胚を用いた機能発現法による新しい神経発生関連遺伝子の探索Principal Investigator
- Principal Investigator
  
  木下典行
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Developmental biology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
  Tokyo Metropolitan Institute for Neuroscience

All 2024 2023 2022 2021 2020 2013 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex2024
- Author(s)
  Nguyen Thanh Phuong、Otani Tetsuhisa、Tsutsumi Motosuke、Kinoshita Noriyuki、Fujiwara Sachiko、Nemoto Tomomi、Fujimori Toshihiko、Furuse Mikio
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 223 Issue: 5 Pages: 1-23
- DOI
  10.1083/jcb.202307104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06663, KAKENHI-PLANNED-21H05286, KAKENHI-PROJECT-20H05669, KAKENHI-PROJECT-21H02523
[Journal Article] Mechanical transapical coupling of endometrial epithelial cells during implantation2023
- Author(s)
  Sakurai Jun、Kinoshita Noriyuki、Otani Tetsuhisa、Koyama Hiroshi、Furuse Mikio、Fujimori Toshihiko
- Journal Title
  
  BioRxiv
  
  Volume: - Pages: 571398-571398
- DOI
  10.1101/2023.12.12.571398
- Open Access
- Data Source
  KAKENHI-PROJECT-20K06663
[Journal Article] Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to cell-cell adhesion through enhancing tight junctions2022
- Author(s)
  Kinoshita, Noriyuki Yamamoto, Takamasa S. Yasue, Naoko Takagi, Chiyo Fujimori, Toshihiko Ueno, Naoto
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 2 Pages: 103846-103846
- DOI
  10.1016/j.isci.2022.103846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06663, KAKENHI-PROJECT-16H06280
[Journal Article] Force-dependent remodeling of a tight junction protein ZO-1 is regulated by phase separation2020
- Author(s)
  Kinoshita Noriyuki、Yamamoto Takamasa S.、Yasue Naoko、Fujimori Toshihiko、Ueno Naoto
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.10.04.323436
- Open Access
- Data Source
  KAKENHI-PROJECT-20K06663
[Journal Article] Transgenic Xenopus laevis for live imaging in cell and developmental biology.2013
- Author(s)
  Takagi, C., Sakamaki, K., Morita, H., Hara, Y., Suzuki, M., Kinoshita, N. and Ueno, N.
- Journal Title
  
  Development, Growth & Differentiation
  
  Volume: 55 Issue: 4 Pages: 422-433
- DOI
  10.1111/dgd.12042
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22127007, KAKENHI-PROJECT-23570262, KAKENHI-PROJECT-23770261, KAKENHI-PROJECT-24370092, KAKENHI-PUBLICLY-23111528
[Journal Article] Wnt/PCPシグナルにおけるユビキチンシステムの役割2010
- Author(s)
  木下典行
- Journal Title
  
  医学のあゆみ
  
  Volume: 233 Pages: 978-982
- Data Source
  KAKENHI-PROJECT-20370090
[Journal Article] 脊椎動物のPCPシグナル2008
- Author(s)
  木下典行
- Journal Title
  
  実験医学
  
  Volume: 26 Pages: 374-379
- Data Source
  KAKENHI-PROJECT-20370090
[Journal Article] XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway2007
- Author(s)
  Lee RH, lioka H, Ohashi M, lemurs S, Natsume T, KINOSHITA N
- Journal Title
  
  EMBO Journal 26
  
  Pages: 3592-3606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570212
[Journal Article] Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility2007
- Author(s)
  Iioka H, Iemura S, Natsume T, KINOSHITA N
- Journal Title
  
  Nature Cell Biology 9
  
  Pages: 813-821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044043
[Journal Article] XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway2007
- Author(s)
  Lee RH, Iioka H, Ohashi M, Iemura S, Natsume T, KINOSHITA N
- Journal Title
  
  EMBO Journal 26
  
  Pages: 3592-3606
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570212
[Presentation] Regulation of collective cell migration via ZO-1 phase separation2022
- Author(s)
  HIRANO Sayuki, KINOSHITA Noriyuki, AOKI Kazuhiro , UENO Naoto
- Organizer
  日本発生生物学会
- Data Source
  KAKENHI-PROJECT-20K06663
[Presentation] Force-dependent remodeling of a tight junction protein ZO-1 is regulated by phase separation2021
- Author(s)
  Noriyuki Kinoshita, Takamasa Yamamoto, Naoko Yasue, Chiyo Takagi, Toshihiko Fujimori, and Naoto Ueno
- Organizer
  日本発生生物学会
- Data Source
  KAKENHI-PROJECT-20K06663
[Presentation] Regulation of paraxial protocadherin (PAPC) by a phosphorylation- dependent ubiquitin system is required for Xenopus early development2013
- Author(s)
  Kai M, and Kinoshita N
- Organizer
  46th annual meeting for the Japanese society of Developmental Biologists
- Place of Presentation
  島根県立産業交流会館くにびきメッセ島根県・松江市)
- Data Source
  KAKENHI-PROJECT-23570262
[Presentation] Regulation of paraxial protocadherin (PAPC) by a phosphorylation-dependent ubiquitin system is required for Xenopus early development2013
- Author(s)
  Kai M and Kinoshita N
- Organizer
  46th annual meeting for the Japanese society of Developmental Biologists
- Place of Presentation
  Shimane, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23570262
[Presentation] Prickle and β-TrCP regulate cell adhesion by controlling paraxial protocadherin activity through ubiquitination in Xenopus development2011
- Author(s)
  Kai M and KINOSHITA N
- Organizer
  Annual meeting of the Japanaese Society of Developmental Biolodists and Asia pacific Developmental Biology Network
- Place of Presentation
  沖縄コンベンションセンター（沖縄県）
- Data Source
  KAKENHI-PROJECT-23570262
[Presentation] Prickleとβ-TrCPはツメガエル初期発生においてparaxial protocadherinをユビキチン化を介して調節することにより細胞接着を制御する2011
- Author(s)
  甲斐理武,木下典行
- Organizer
  日本発生生物学会
- Place of Presentation
  沖縄コンベンションセンター
- Data Source
  KAKENHI-PROJECT-20370090
[Presentation] Prickle and β-TrCP regulate cell adhesion by controlling paraxial protocadherin activity through ubiquitination in Xenopus development.2011
- Author(s)
  木下典行、甲斐理武
- Organizer
  日本発生生物学会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-23111528
[Presentation] Prickle andβ-TrCP regulate cell adhesion by controlling paraxial protocadherin activity through ubiquitination in Xenopus development2011
- Author(s)
  Kai M and Kinoshita N
- Organizer
  44th annual meeting for the Japanese society of Developmental Biologists
- Place of Presentation
  沖縄コンベンションセンター(沖縄県・宜野湾市)
- Data Source
  KAKENHI-PROJECT-23570262
[Presentation] Dissecting biological functions of a Wnt/PCP pathway component Prickle2010
- Author(s)
  Masatake kai, Noriyuki Kinoshita
- Organizer
  The 16^<th> International Conference of the INTERNATIONAL SOCIETY OF DIFFERENTIATION
- Place of Presentation
  奈良県立公会堂
- Data Source
  KAKENHI-PROJECT-20370090
[Presentation] The ubiquitin system regulates PCP protein localizations in Xenopus embryonic cells.2010
- Author(s)
  Noriyuki Kinoshita
- Organizer
  The international conference of the Internatitonal Society of Differentiation
- Place of Presentation
  奈良県新公会堂(奈良)
- Data Source
  KAKENHI-PROJECT-20370090
[Presentation] アフリカツメガエル胚細胞においてユビキチンシステムがPCPタンパク質の局在を制御する2010
- Author(s)
  木下典行
- Organizer
  日本発生生物学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-20370090
[Presentation] The ubiquitin system regulates PCP protein localizations in Xenopus embryonic cells.2010
- Author(s)
  Noriyuki Kinoshita
- Organizer
  Annual meeting of the Japanaese Society of Developmental Biolodists
- Place of Presentation
  国立京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-20370090
[Presentation] Ubiquitin system regulates the localization of Wnt/PCP signal proteins in Xenopus embryonic cells2010
- Author(s)
  Noriyuki Kinoshita, Masatake kai
- Organizer
  The 16^<th> International Conference of the INTERNATIONAL SOCIETY OF DIFFERENTIATION
- Place of Presentation
  奈良県立公会堂
- Data Source
  KAKENHI-PROJECT-20370090
[Presentation] Wnt/PCPシグナルのユビキチン化酵素による制御2009
- Author(s)
  木下典行
- Organizer
  九州大学GCOEシンポジウム
- Place of Presentation
  九州大学医学部
- Year and Date
  2009-03-24
- Data Source
  KAKENHI-PROJECT-20370090
[Presentation] Wnt/PCPシグナル伝達のユビキチン化酵素による制御2009
- Author(s)
  木下典行
- Organizer
  九州大学GCOEシンポジウム「Wntシグナルの機能と制御」
- Place of Presentation
  九州大学医学部
- Year and Date
  2009-03-24
- Data Source
  KAKENHI-PROJECT-19044043
[Presentation] Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility2008
- Author(s)
  Noriyuki Kinoshita
- Organizer
  Santa Cruz Developmental Biology Meeting at University of California, Santa Cruz
- Place of Presentation
  アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-20370090

1. UENO Naoto (40221105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. TABATA Tetsuya (10183865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TSUNEIZUMI Kazuhide (40280953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 藤森俊彦 (80301274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大谷哲久 (50415105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SUZUKI Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kinoshita Noriyuki 木下 典行

木下 典行 キノシタ ノリユキ

KINOSHITA Noriyuki 木下 典行

Research Projects

Research Products

Co-Researchers

マウス胚着床における胚ー子宮相互作用を起点とした子宮上皮の組織形態変化の制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

上皮細胞が頂端面で力学的に”連結”する機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Force-dependent control of cell-to-cell adhesion through the regulation of ZO-1 phase separation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanically activated protein kinases regulate mesenchymal-epithelial transition-like reaction in early embryonic ectodermPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ｗｎｔシグナルは細胞間接着の調節を通して脊索形成での細胞運動を制御するPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The regulation of cell movement by the ubiquitin system.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of ubiquitin system in Xenopus gastrulation movementsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

原腸形成過程においてWntシグナルが制御する新規ユビキチン化・分解経路Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of membrane trafficking in Wnt signaling that regulates gastrulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of cell polarity formation mechanism in archenteron formation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular and cellular analyses of the Wnt signaling pathway that regulates Xenopus gastrulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of novel patterning genes in Drosophila development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

カエル初期胚を用いた機能発現法による新しい神経発生関連遺伝子の探索Principal Investigator

Principal Investigator

Kinoshita Noriyuki 木下典行

木下典行キノシタノリユキ

KINOSHITA Noriyuki 木下典行