Mihara Kazuo 三原一雄

… Alternative Names

三原一雄ミハラカズオ

MIHARA Kazuo 三原一雄

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Researcher Number	30302029
Other IDs
Affiliation (Current)	2025: 琉球大学, 医学(系)研究科(研究院), 客員研究員
Affiliation (based on the past Project Information) *help	2020 – 2021: 琉球大学, 医学(系)研究科(研究院), 客員研究員 2013 – 2019: 琉球大学, 医学(系)研究科(研究院), 准教授 2010: 琉球大学, 医学研究科, 准教授 2009 – 2010: 国立大学法人琉球大学, 医学部, 准教授 2007 – 2008: 琉球大学, 医学部, 准教授 2004 – 2006: 琉球大学, 医学部, 助教授 2000 – 2002: 弘前大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science / Psychiatric science Except Principal Investigator Psychiatric science / Psychiatric science
Keywords	Principal Investigator 遅発性ジストニア / 統合失調症 / サイトカイン / 腫瘍壊死因子 / 治療反応性 / TNF-α / UGT2B7 / 遺伝子多型 / UGT / 血漿濃度 … More / ラモトリギン / 難治性うつ病性障害 / 臨床反応 / 受容体遺伝子多型 / 抗精神病薬 / Dopamine D2 受容体 / cytochrome P4502D6 / 遺伝的多型性 / ドーパミン受容体 / 神経遮断薬悪性症候群 … More Except Principal Investigator -141C Del / 抑うつ性混合状態 / 抗精神病薬 / Ins遺伝子多型 / -141 Del / TaqI A遺伝子多型 / ドーパミン受容体 / 治療抵抗性うつ病 / CYP2D6 / 神経免疫 / 神経生理 / 脆弱な反応・応答性 / 探索的因子分析 / DMX-5 / 混合性特徴 / 混合うつ病 / 破壊的感情/行動 / DMX-12 / うつ病エピソード / 脆弱な応答性 / 内発的な不安定さ / スクリーニング / 若年 / 双極性 / 重症度 / 破壊的な感情/行動 / 定量的評価 / treatment-resistance / hyperprolactinemia / neuroleptic malignant syndrome / anxiety-depression symptoms / positive symptoms / Ins polymorphism / TaqI A polymorphism / dopamine D2 receptor / 錐体外路症状 / 抗ドーパミン作用 / 精神分裂病症状 / TaqIA遺伝子多型性 / プロラクチン反応 / CYP2D6 genotype / Carbamazepine / Risperidone / 定型抗精神病薬 / 治療抵抗性 / 高プロラクチン血症 / 神経遮断薬悪性症候群 / 不安-抑うつ症状 / 陽性症状 / 気質 / 遺伝子多型 / 薬物動態 / 光トポグラフィー / 電気痙攣療法 / 自閉症スペクトラム障害 / 薬物相互作用 / エスシタロプラム / パロキセチン / アリピプラゾール / 因子分析 / 量的評価 / 混合病像 / 至適投与量 / 血漿濃度 / バルプロ酸 / 治療抵抗性気分障害 / 自殺リスク / 自閉スペクトラム症 / 有効血漿濃度 / ラモトリギン / 難治性気分障害 / ノルアドレナリン / セロトニン / うつ病 / 治療反応性 / 治療脱落例 / TCI / SASS / mianserin / paroxetine / 治療前危険因子 / 思春期症例 / GAF / MADRS / lamotrigine / genotyping / *10アレル / aripiprazole / 循環気質 / soft bipolarity / TEMPS-A/MPT / 病前気質 / 自殺関連事象 / 気分安定薬 / 抗うつ薬 / 遺伝多型 / 気質性格因子 / うつ病性障害 Less

Elucidation of the pathophysiology and the treatment strategy of refractory depressive disorder from the viewpoint of tumor necrosis factorPrincipal Investigator
- Principal Investigator
  
  Mihara Kazuo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  University of the Ryukyus
Quantification and biological backgrounds of depressive mixed state
- Principal Investigator
  
  Kondo Tsuyoshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  University of the Ryukyus
Development of rational treatment strategy for refractory mood disorders
- Principal Investigator
  
  Kondo Tsuyoshi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  University of the Ryukyus
Development of treatment algorithm for depressive disorders using genetic and biological markers
- Principal Investigator
  
  KONDO Tsuyoshi
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  University of the Ryukyus
統合失調症難治化の遺伝的要因の解明Principal Investigator
- Principal Investigator
  
  三原一雄
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  University of the Ryukyus
神経遮断薬悪性症候群の病態と遺伝的素因の解明Principal Investigator
- Principal Investigator
  
  三原一雄
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hirosaki University
Study on clinical implication of dopamine and serotonin receptor polymorphisms as pharmacodynamic markers for neuroleptic response
- Principal Investigator
  
  KONDO Tsuyoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Hirosaki University

All 2022 2020 2019 2018 2017 2016 2015 2014 2013 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] UGT2B7 372A>G Polymorphism is related to a Therapeutic Response to Lamotrigine Augmentation Therapy in Depressed Patients Who Did Not Respond to Adequate Treatment: A Preliminary Study2022
- Author(s)
  Shoko Kagawa, Kazuo Mihara, Takeshi Suzuki, Goyo Nagai, Akifumi Nakamura, Kenji Nemoto, Tsuyoshi Kondo
- Journal Title
  
  Systematic Review in Pharmacology
  
  Volume: 13(3) Pages: 261-264
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07607
[Journal Article] A High Plasma Lamotrigine Concentration at Week 2 as a Risk Factor for Lamotrigine-Related Rash.2020
- Author(s)
  Suzuki Takeshi, Mihara Kazuo, Nagai Goyo, Kagawa Shoko, Nakamura Akifumi, Nemoto Kenji, Kondo Tsuyoshi
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: － Issue: 4 Pages: 631-635
- DOI
  10.1097/ftd.0000000000000733
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10311, KAKENHI-PROJECT-18K07607
[Journal Article] Relationship Between UGT1A4 and UGT2B7 Polymorphisms and the Steady-State Plasma Concentrations of Lamotrigine in Patients With Treatment-Resistant Depressive Disorder Receiving Lamotrigine as Augmentation Therapy2019
- Author(s)
  Suzuki Takeshi、Mihara Kazuo、Nagai Goyo、Kagawa Shoko、Nakamura Akifumi、Nemoto Kenji、Kondo Tsuyoshi
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 41 Issue: 1 Pages: 86-90
- DOI
  10.1097/ftd.0000000000000577
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10311, KAKENHI-PROJECT-18K07607
[Journal Article] A Partial Response at Week 4 Can Predict Subsequent Outcome during Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder: A Preliminary Study2018
- Author(s)
  Nagai Goyo、Mihara Kazuo、Kagawa Shoko、Nakamura Akifumi、Suzuki Takeshi、Nemoto Kenji、Kondo Tsuyoshi
- Journal Title
  
  Neuropsychobiology
  
  Volume: 76 Issue: 4 Pages: 187-192
- DOI
  10.1159/000489967
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10311, KAKENHI-PROJECT-18K07607
[Journal Article] Both serum brain-derived neurotrophic factor and interleukin-6 levels are not associated with therapeutic response to lamotrigine augmentation therapy in treatment-resistant depressive disorder2017
- Author(s)
  Kagawa S, Mihara K, Suzuki T, Nagai G, Nakamura A, Nemoto K, Kondo T
- Journal Title
  
  Neuropsychobiology
  
  Volume: 75 Issue: 3 Pages: 145-150
- DOI
  10.1159/000484665
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10311
[Journal Article] Prediction of an optimal dose of lamotrigine for augmentation therapy in treatment-resistant depressive disorder from plasma lamotrigine concentration at week 22016
- Author(s)
  Nakamura A, Mihara K, Nagai G, Kagawa S, Suzuki T, Nemoto K, Kondo T
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: Epub ahead Issue: 3 Pages: 379-382
- DOI
  10.1097/ftd.0000000000000279
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461736
[Journal Article] Prediction of an optimal dose of aripiprazole in the treatment of schizophrenia from plasma concentrations of aripiprazole plus its active metabolite dehydroaripiprazole at week 1.2016
- Author(s)
  Nagai G, Mihara K, Nakamura A, Nemoto K, Kagawa S, Suzuki T, Kondo T
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 39 Issue: 1 Pages: 62-65
- DOI
  10.1097/ftd.0000000000000358
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461736, KAKENHI-PROJECT-17K10311
[Journal Article] Lamotrigine augmentation therapy in a case with treatment-resistant unipolar depression that showed insufficient response to electroconvulsive therapy2016
- Author(s)
  Mihara K, Nakamura A, Nemoto K, Nagai G, Kagawa S, Suzuki T, Kondo T
- Journal Title
  
  Psychiatry Clinical Neuroscience
  
  Volume: 70 Issue: 2 Pages: 126-126
- DOI
  10.1111/pcn.12376
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461736
[Journal Article] Effects of escitalopram on plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in Japanese patients.2014
- Author(s)
  Nemoto K, Mihara K, Nakamura A, Nagai G, Kagawa S, Suzuki T, Kondo T
- Journal Title
  
  Pharmacopsychiatry
  
  Volume: 47 Issue: 03 Pages: 101-104
- DOI
  10.1055/s-0034-1372644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461736
[Journal Article] Lamotrigineの双極性障害への適応2014
- Author(s)
  中村明文，三原一雄，香川祥子，友利陽子，近藤毅
- Journal Title
  
  臨床精神薬理
  
  Volume: 17 Pages: 971-978
- Data Source
  KAKENHI-PROJECT-25461736
[Journal Article] Relationship between plasma concentrations of lamotrigine and its early therapeutic effect of lamotrigine augmentation therapy in treatment-resistant depressive disorder.2014
- Author(s)
  Kagawa S, Mihara K, Nakamura A, Nemoto K, Suzuki T, Nagai G, Kondo T
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 36 Issue: 6 Pages: 730-733
- DOI
  10.1097/ftd.0000000000000088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461736
[Journal Article] Lack of correlation between the steady-state plasma concentrations of aripiprazole and haloperidol in Japanese patients with schizophrenia.2014
- Author(s)
  Nakamura A, Mihara K, Nemoto K, Nagai G, Kagawa S, Suzuki T, Kondo T
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 36 Issue: 6 Pages: 815-818
- DOI
  10.1097/ftd.0000000000000082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461736
[Journal Article] 気質が気分障害の臨床的特徴と治療反応性に与える影響について2014
- Author(s)
  三原一雄、甲田宗良、中村明文、近藤毅
- Journal Title
  
  臨床精神薬理
  
  Volume: 17 Pages: 175-180
- Data Source
  KAKENHI-PROJECT-25461736
[Journal Article] Effects of genetic polymorphisms of CYP2D6, CYP3A5 and ABCB1 on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in Japanese patients with schizophrenia2014
- Author(s)
  Suzuki T, Mihara K, Nakamura A, Kagawa S, Nagai G, Nemoto K, Kondo T
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461736
[Journal Article] 気質が気分障害の臨床的特徴と治療反応性に与える影響について－循環気質と発揚気質に焦点を当てて－2014
- Author(s)
  三原一雄，甲田宗良，中村明文，近藤毅
- Journal Title
  
  臨床精神薬理
  
  Volume: 17 Pages: 175-180
- Data Source
  KAKENHI-PROJECT-25461736
[Journal Article] Effects of CYP2D6*10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole in Japanese patients with schizophrenia.2011
- Author(s)
  Suzuki T, Mihara K, Nakamura A, Nagai G, Kagawa S, Nemoto K, Ohta I, Arakaki G, Uno T, Kondo T
- Journal Title
  
  Therapeutic Drug Monitorong 33
  
  Pages: 21-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591366
[Journal Article] Lamotrigine augmentation for the treatment-resistant mood disorder.2010
- Author(s)
  Kagawa S, Nemoto K, Suzuki T, Nagai G, Nakamura A, Mihara K, Kondo T
- Journal Title
  
  Clinical Neuropsychopharmacology and Therapeutics 1
  
  Pages: 35-42
- NAID
  130000405626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591366
[Journal Article] Formulations of valproate alter valproate metabolism : a single oral dose kinetic study.2009
- Author(s)
  Nagai G, Ono S, Yasui-Furukori N, Nakamura A, Mihara K, Kondo T.
- Journal Title
  
  Therapeutic Drug Monitoring 31
  
  Pages: 592-596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591366
[Journal Article] Pharmacokinetic and pharmacodynamic interactions between carbamazepine and aripiprazole in patients with schizophrenia.2009
- Author(s)
  中村明文, 三原一雄, 永井五洋, 鈴木毅, 近藤毅
- Journal Title
  
  Therapeutic Drug Monitoring 31
  
  Pages: 575-578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591366
[Journal Article] Formulations of valproate alter valproate metabolism : a single oral dose kinetic study2009
- Author(s)
  Nagai G, Ono S, Yasui-Furukori N, Nakamura A, Mihara K, Kondo T.
- Journal Title
  
  Therapeutic Drug Monitoring 31
  
  Pages: 592-596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591366
[Journal Article] Pharmacokinetic and pharmacodynamic interactions between carbamazepine and aripiprazole in patients with schizophrenia2009
- Author(s)
  Nakamura A, Mihara K, Nagai G, Suzuki T, Kondo T.
- Journal Title
  
  Therapeutic Drug Monitoring 31
  
  Pages: 575-578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591366
[Journal Article] 薬物相互作用2007
- Author(s)
  三原一雄
- Journal Title
  
  臨床精神医学 36
  
  Pages: 48-53
- Data Source
  KAKENHI-PROJECT-19591366
[Journal Article] 薬物相互作用2007
- Author(s)
  三原一雄, 中村明文, 永井五洋, 鈴木毅, 近藤毅
- Journal Title
  
  臨床精神医学 36
  
  Pages: 48-53
- Data Source
  KAKENHI-PROJECT-19591366
[Journal Article] Dopamine D2 receptor gene polymorphisms predict well the response to dopamine antagonists at therapeutic dosages in patients with schizophrenia.2007
- Author(s)
  Sakumoto N, Kondo T, Mihara K, Suzuki A, Yasui-Furukori N
- Journal Title
  
  Psychiatry Clinical Neuroscience 61
  
  Pages: 174-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591366
[Journal Article] Dopamine D2 receptor gene polymorphisms predict well the response to dopamine antagonists at therapeutic dosages in patients with schizophrenia2007
- Author(s)
  Sakumoto N, Kondo T, Mihara K, Suzuki A, Yasui-Furukori N
- Journal Title
  
  Psychiatry Clinical Neuroscience 61
  
  Pages: 174-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] 難治性うつ病性障害におけるラモトリギン強化療法の治療反応性とUGT2B7遺伝子多型との関連2019
- Author(s)
  香川祥子、鈴木　毅、永井五洋、中村明文、根本健二、三原一雄、近藤　毅
- Organizer
  第29回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-18K07607
[Presentation] Lamotrigineによる難治性うつ病性障害強化療法の治療反応性とAMPA受容体GRM2遺伝子多型との関連性について2019
- Author(s)
  村明文、永井五洋、香川祥子、鈴木毅、根本健二、三原一雄、近藤毅
- Organizer
  日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-17K10311
[Presentation] 難治性うつ病性障害におけるラモトリギン強化療法の治療反応性とUGT1A4及びUGT２B7遺伝子多型との関連2019
- Author(s)
  香川祥子、鈴木毅、永井五洋、中村明文、根本健二、三原一雄、近藤毅
- Organizer
  日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-17K10311
[Presentation] 難治性うつ病性障害に対するラモトリギン強化療法においてABCG2 C421Aがラモトリギン血漿濃度に与える影響2019
- Author(s)
  鈴木　毅、中村明文、香川祥子、永井五洋、根本健二、三原一雄、近藤　毅
- Organizer
  第29回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-18K07607
[Presentation] 難治性うつ病性障害に対するラモトリギン強化療法患者においてABCG2 C421Aがラモトリギン血漿濃度に与える影響2019
- Author(s)
  鈴木毅、永井五洋、中村明文、香川祥子、根本健二、三原一雄、近藤毅
- Organizer
  日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-17K10311
[Presentation] 難治性うつ病性障害におけるラモトリギン強化療法の治療反応性とABCG2 C421A遺伝子多型との関連2019
- Author(s)
  永井五洋、鈴木毅、香川祥子、中村明文、根本健二、三原一雄、近藤毅
- Organizer
  日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-17K10311
[Presentation] Lamotrigineによる難治性うつ病性障害強化療法の治療反応性とAMPA受容体GRM2遺伝子多型との関連性について2019
- Author(s)
  永井五洋、鈴木　毅、香川祥子、中村明文、根本健二、三原一雄、近藤　毅
- Organizer
  第29回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-18K07607
[Presentation] 難治性うつ病性障害に対するlamotrigine強化療法において、lamotrigine投与量予測に有用と考えられるnomogramの妥当性を検証する2018
- Author(s)
  中村明文、永井五洋、香川祥子、鈴木毅、根本健二、三原一雄、近藤毅
- Organizer
  第28回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-18K07607
[Presentation] 治療2週目のlamotrigine血漿濃度高値がlamotrigineによる皮疹発現と関連する2018
- Author(s)
  永井五洋、鈴木毅、香川祥子、中村明文、三原一雄、近藤毅
- Organizer
  第28回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-18K07607
[Presentation] 難治性うつ病性障害に対するlamotrigine強化療法においてlamotrigine投与量予測に有用と考えられるnomogramの妥当性を検証する2018
- Author(s)
  中村明文，永井五洋，香川祥子，鈴木毅，根本健二，三原一雄，近藤毅
- Organizer
  第28回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-17K10311
[Presentation] 治療2週目のlamotrigine血漿濃度高値がlamotrigineによる皮疹発現と関連する2018
- Author(s)
  永井五洋，鈴木毅，香川祥子，中村明文，三原一雄，近藤毅
- Organizer
  第28回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-17K10311
[Presentation] 難治性うつ病性障害におけるラモトリギン強化療法の治療反応性とUGT1A4 142T>G遺伝子多型との関連2018
- Author(s)
  香川祥子，鈴木毅，永井五洋，中村明文，根本健二，三原一雄，近藤毅
- Organizer
  第28回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-17K10311
[Presentation] 難治性うつ病性障害におけるラモトリギン強化療法の治療反応性とUGT1A4 142>G遺伝子多型との関連2018
- Author(s)
  香川祥子、鈴木毅、永井五洋、中村明文、根本健二、三原一雄、近藤毅
- Organizer
  第28回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-18K07607
[Presentation] 難治性うつ病性障害に対するラモトリギン強化療法患者においてUGT1A4 142T>GとUGT2B7 372A>G、-161C>Tがラモトリギン血漿濃度に与える影響2017
- Author(s)
  鈴木毅、中村明文、香川祥子、永井五洋、根本健二、三原一雄、近藤毅
- Organizer
  第27回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-17K10311
[Presentation] 統合失調症治療1週後のaripiprazoleと活性代謝産物血漿濃度から至適投与量を予測する2017
- Author(s)
  中村明文、永井五洋、根本健二、香川祥子、鈴木毅、三原一雄、近藤毅
- Organizer
  第27回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-17K10311
[Presentation] 広汎性発達障害における薬物療法．成人ASDの抑うつに対する薬物および非薬物性療法．2016
- Author(s)
  中村明文，三原一雄，高良聖治，近藤　毅
- Organizer
  第26回日本臨床精神神経薬理学会
- Place of Presentation
  ホルトホール大分（大分県・大分市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] Lamotrigineによる難治性うつ病性障害強化療法の治療反応性とABCB1遺伝子多型との関連性について．2016
- Author(s)
  永井五洋，鈴木毅，香川祥子，中村明文，三原一雄，近藤　毅
- Organizer
  第26回日本臨床精神神経薬理学会
- Place of Presentation
  ホルトホール大分（大分県・大分市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] 難治性うつ病性障害に対するラモトリギン強化療法患者においてUGT1A4 142T>Gがラモトリギン血漿濃度に与える影響．2016
- Author(s)
  鈴木毅，中村明文，香川祥子，永井五洋，根本健二，三原一雄，近藤　毅
- Organizer
  第26回日本臨床精神神経薬理学会
- Place of Presentation
  ホルトホール大分（大分県・大分市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] 難治性うつ病性障害におけるラモトリギン強化療法の治療反応性とMTHFR C677T遺伝子多型との関連．2016
- Author(s)
  香川祥子，根本健二，鈴木毅，永井五洋，中村明文，三原一雄，近藤　毅
- Organizer
  第26回日本臨床精神神経薬理学会
- Place of Presentation
  ホルトホール大分（大分県・大分市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] バルプロ酸による高アンモニア血症に対するカルニチン補充療法について2015
- Author(s)
  中村明文，永井五洋，鈴木毅，根本健二，香川祥子，三原一雄，福治康秀，宮里好一，久場禎三，近藤毅
- Organizer
  第25回日本臨床精神神経薬理学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] 難治性うつ病性障害に対するラモトリギン強化療法が与える血漿アミロイドβたんぱく代謝への影響について2015
- Author(s)
  鈴木毅，中村明文，香川祥子，根本健二，永井五洋，三原一雄，近藤毅
- Organizer
  第25回日本臨床精神神経薬理学会
- Place of Presentation
  京王プラザホテル　(東京都新宿区)
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] 精神科領域におけるバルプロ酸服用者の血漿アンモニアと血清カルニチン濃度について2015
- Author(s)
  中村明文，永井五洋，鈴木毅，根本健二，香川祥子，三原一雄，福治康秀，宮里好一，久場禎三，近藤毅
- Organizer
  第25回日本臨床精神神経薬理学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] 年地性うつ病性障害に対するラモトリギン強化療法の治療反応と血漿アミロイドβたんぱくとの関係2015
- Author(s)
  香川祥子，根本健二，鈴木毅，永井五洋，中村明文，三原一雄，近藤毅
- Organizer
  第25回日本臨床精神神経薬理学会
- Place of Presentation
  京王プラザホテル　（東京都新宿区)
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] CYP酵素を介した薬物相互作用2013
- Author(s)
  中村明文、三原一雄、近藤毅
- Organizer
  第43回日本臨床精神神経薬理学会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] Escitalopram併用がaripiprazoleとその活性代謝物dehydroaripiprazoleの薬物動態に与える影響について2013
- Author(s)
  中村明文、根本健二、香川祥子、永井五洋、鈴木毅、三原一雄、近藤毅
- Organizer
  第66回九州精神神経学会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] Aripiprazoleとその活性代謝産物dehydroaripiprazoleとhaloperidolの定常状態血漿濃度との関連について2013
- Author(s)
  根本健二、中村明文、永井五洋、鈴木毅、香川祥子、三原一雄、近藤毅
- Organizer
  第43回日本臨床精神神経薬理学会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] 難治性うつ病性障害におけるラモトリギン強化療法とBDNFの推移2013
- Author(s)
  香川祥子、根本健二、鈴木毅、永井五洋、中村明文、三原一雄、近藤毅
- Organizer
  第43回日本臨床精神神経薬理学会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] Aripiprazoleとdehydroaripiprazoleの定常状態血漿濃度に及ぼす種々の要因の検討2010
- Author(s)
  鈴木毅, 三原一雄, 永井五洋, 中村明文, 香川祥子, 根本健二, 宇野司, 近藤毅
- Organizer
  第20回日本臨床精神神経薬理学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] 気質傾向と難治性うつ病におけるラモトリギン強化療法の治療反応性2010
- Author(s)
  香川祥子, 根本健二, 鈴木毅, 永井五洋, 中村明文, 三原一雄, 近藤毅
- Organizer
  第20回日本臨床精神神経薬理学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] 双極スペクトラム障害(mixed depression)と診断することの意義2010
- Author(s)
  中村明文, 香川祥子, 仲本譲, 三原一雄, 近藤毅
- Organizer
  第30回日本精神科診断学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] Lamotrigine augmentation in the treatment of refractory depression.2009
- Author(s)
  香川祥子, 根本健二, 鈴木毅, 永井五洋, 中村明文, 三原一雄, 近藤毅
- Organizer
  The 1st meeting of the Asian College of Neuropsychopharma-cology
- Place of Presentation
  Kyoto
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] Lamotrigine augmentation in the treatment of refractory depression2009
- Author(s)
  Kagawa S, Nemoto K, Suzuki T, Nagai G, Nakamura A, Mihara K, Kondo T.
- Organizer
  The 1st meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] Effects of CYP2D6*10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole in Japanese patients schizophrenia.2009
- Author(s)
  Suzuki T, Mihara K, Nagai G, Nakamura A, Nemoto K, Kagawa S, Uno T, Kondo T
- Organizer
  The 1st meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] Effects of paroxetine on plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole in schizophrenic patients2009
- Author(s)
  Nemoto, K, Nakamura A, Nagai G, Kagawa S, Mihara K, Kondo T.
- Organizer
  The 1st meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] Effects of paroxetine on plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole in schizophrenic patients.2009
- Author(s)
  根本健二, 中村明文, 永井五洋, 香川祥子, 三原一雄, 近藤毅
- Organizer
  The 1st meeting of the Asian College of Neuropsychopharma-cology.
- Place of Presentation
  Kyoto
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] Effects of CYP2D6^*10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole in Japanese patients with schizophrenia2009
- Author(s)
  Suzuki T, Mihara K, Nagai G, Nakamura A, Nemoto K, Kagawa S, Uno T, Kondo T.
- Organizer
  The 1st meeting of the Asian College of Neuropsychopharmacology
- Place of Presentation
  Kyoto
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] Carbamazepine がaripiprazoleとその活性代謝物dehydroaripiprazoleの血漿濃度に与える影響2008
- Author(s)
  中村明文, 永井五洋, 三原一雄, 鈴木毅, 近藤毅
- Organizer
  第18回日本臨床精神神経薬理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] 日本人統合失調症患者においてCYP2D6遺伝型がaripiprazoleとdehydroaripiprazoleの定常状態血漿濃度に与える影響2008
- Author(s)
  鈴木毅, 三原一雄, 永井五洋, 中村明文, 宇野司, 近藤毅
- Organizer
  第18回日本臨床精神神経薬理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] アリピプラゾール上乗せ投与による薬剤性高プロラクチン血症の改善2008
- Author(s)
  永井五洋, 中村明文, 鈴木毅, 三原一雄, 近藤毅
- Organizer
  第18回日本臨床精神神経薬理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591366
[Presentation] 難治性うつ病性障害におけるラモトリギン強化療法の治療反応性とIL-6, BDNF/IL6比の関係
- Author(s)
  香川祥子, 根本健二, 鈴木毅, 永井五洋, 中村明文, 三原一雄, 近藤毅
- Organizer
  第24回日本臨床精神神経薬理学会
- Place of Presentation
  名古屋国際会議場　名古屋
- Year and Date
  2014-11-20 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] Quetiapineとlamotrigineの薬物相互作用
- Author(s)
  中村明文, 永井五洋, 鈴木毅, 根本健二, 香川祥子, 三原一雄, 近藤毅
- Organizer
  第24回日本臨床精神神経薬理学会
- Place of Presentation
  名古屋国際会議場　名古屋
- Year and Date
  2014-11-20 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25461736
[Presentation] 難治性うつ病性障害に対するlamotrigine強化療法において必要なlamotorigine投与量を予測する
- Author(s)
  永井五洋, 香川祥子, 根本健二, 鈴木毅, 中村明文, 三原一雄, 近藤毅
- Organizer
  第24回日本臨床精神神経薬理学会
- Place of Presentation
  名古屋国際会議場　名古屋
- Year and Date
  2014-11-20 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25461736

1. KONDO Tsuyoshi (40215455)

# of Collaborated Projects: 5 results

# of Collaborated Products: 66 results
2. NAKAMURA AKifumi (40381222)

# of Collaborated Projects: 2 results

# of Collaborated Products: 44 results
3. KANEKO Sunao (40106852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 甲田宗良 (50736189)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 新里輔鷹 (20838057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mihara Kazuo 三原 一雄

三原 一雄 ミハラ カズオ

MIHARA Kazuo 三原 一雄

Research Projects

Research Products

Co-Researchers

Elucidation of the pathophysiology and the treatment strategy of refractory depressive disorder from the viewpoint of tumor necrosis factorPrincipal Investigator

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Quantification and biological backgrounds of depressive mixed state

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Development of rational treatment strategy for refractory mood disorders

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Development of treatment algorithm for depressive disorders using genetic and biological markers

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統合失調症難治化の遺伝的要因の解明Principal Investigator

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神経遮断薬悪性症候群の病態と遺伝的素因の解明Principal Investigator

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Study on clinical implication of dopamine and serotonin receptor polymorphisms as pharmacodynamic markers for neuroleptic response

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[Journal Article] UGT2B7 372A>G Polymorphism is related to a Therapeutic Response to Lamotrigine Augmentation Therapy in Depressed Patients Who Did Not Respond to Adequate Treatment: A Preliminary Study2022

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Journal Title

Data Source

[Journal Article] A High Plasma Lamotrigine Concentration at Week 2 as a Risk Factor for Lamotrigine-Related Rash.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship Between UGT1A4 and UGT2B7 Polymorphisms and the Steady-State Plasma Concentrations of Lamotrigine in Patients With Treatment-Resistant Depressive Disorder Receiving Lamotrigine as Augmentation Therapy2019

Author(s)

Journal Title

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[Journal Article] A Partial Response at Week 4 Can Predict Subsequent Outcome during Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder: A Preliminary Study2018

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[Journal Article] Both serum brain-derived neurotrophic factor and interleukin-6 levels are not associated with therapeutic response to lamotrigine augmentation therapy in treatment-resistant depressive disorder2017

Author(s)

Journal Title

DOI

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[Journal Article] Prediction of an optimal dose of lamotrigine for augmentation therapy in treatment-resistant depressive disorder from plasma lamotrigine concentration at week 22016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prediction of an optimal dose of aripiprazole in the treatment of schizophrenia from plasma concentrations of aripiprazole plus its active metabolite dehydroaripiprazole at week 1.2016

Author(s)

Journal Title

Mihara Kazuo 三原一雄

三原一雄ミハラカズオ

MIHARA Kazuo 三原一雄

[Journal Article] 気質が気分障害の臨床的特徴と治療反応性に与える影響について－循環気質と発揚気質に焦点を当てて－2014