Kukimoto Mutsuko 柊元睦子

… Alternative Names

柊元睦子クキモトムツコ

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Researcher Number	30321756
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級技師
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級技師 2022 – 2023: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級技師 2018 – 2021: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 2017: 国立研究開発法人理化学研究所, その他, 研究員 2015 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 上級研究員
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Transformative Research Areas, Section (III) / Basic Section 43030:Functional biochemistry-related / Structural biochemistry Except Principal Investigator General pharmacology
Keywords	Principal Investigator Gタンパク質 / Rho / GEF / DOCK / Rac / 細胞骨格 / クライオ電子顕微鏡 / シグナル伝達 / X線結晶構造解析 / 細胞骨格制御 … More / X戦結晶構造解析 / SPR / 細胞運動 / ELMO / X線結晶解析 / 結晶構造解析 / 低分子量Gタンパク質 / グアニンヌクレオチド交換因子 / Rhoファミリー … More Except Principal Investigator タンパク質相互作用解析 / タンパク質構造解析 / 薬理学 / 受容体・シグナル伝達系 / タンパク質相互作用 / G12/13 / RhoGTPase / 三量体Gタンパク質 / 受容体　シグナル伝達系 / シグナル伝達 / RhoA / 3量体Gタンパク質 / クライオ電子顕微鏡 / X線結晶構造解析 / RhoGEF / G12／13 / Gタンパク質 / 細胞情報伝達 Less

細胞形態形成におけるRhoGEFの多量体化および複合体形成の役割Principal Investigator
- Principal Investigator
  
  柊元睦子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Analysis of intracellular molecular conformational dynamics in cytoskeletal regulatory signalingPrincipal Investigator
- Principal Investigator
  
  柊元睦子
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of the structural basis of proteins that regulate cell motilityPrincipal Investigator
- Principal Investigator
  
  Kukimoto Niino
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Structure and analysis of Ga13-RhoGEF signaling mechanism
- Principal Investigator
  
  Kozasa Tohru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama College of Pharmacy
Elucidation of regulatory mechanism of RhoGEF by multidomains cooperationPrincipal Investigator
- Principal Investigator
  
  Kukimoto Mutsuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2021 2017

All Journal Article Presentation

[Journal Article] Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor2023
- Author(s)
  Kukimoto-Niino M, Ihara K, Mishima-Tsumagari C, Inoue M, Fukui Y, Yokoyama S, Shirouzu M
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 653 Pages: 12-20
- DOI
  10.1016/j.bbrc.2023.02.054
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22H05551
[Journal Article] Structural insights into the small GTPase specificity of the DOCK guanine nucleotide exchange factors2021
- Author(s)
  Kukimoto-Niino Mutsuko、Ihara Kentaro、Murayama Kazutaka、Shirouzu Mikako
- Journal Title
  
  Current Opinion in Structural Biology
  
  Volume: 71 Pages: 249-258
- DOI
  10.1016/j.sbi.2021.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06575
[Journal Article] A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK82021
- Author(s)
  Sakurai Tetsuya、Kukimoto-Niino Mutsuko、Kunimura Kazufumi、Yamane Nana、Sakata Daiji、Aihara Ryosuke、Yasuda Tomoharu、Yokoyama Shigeyuki、Shirouzu Mikako、Fukui Yoshinori、Uruno Takehito
- Journal Title
  
  Life Science Alliance
  
  Volume: 4 Issue: 4 Pages: e202000873-e202000873
- DOI
  10.26508/lsa.202000873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06575, KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-19K22538, KAKENHI-PROJECT-19H00983, KAKENHI-PROJECT-21H02751, KAKENHI-PROJECT-18H02406
[Journal Article] Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex2021
- Author(s)
  Kukimoto-Niino Mutsuko、Katsura Kazushige、Kaushik Rahul、Ehara Haruhiko、Yokoyama Takeshi、Uchikubo-Kamo Tomomi、Nakagawa Reiko、Mishima-Tsumagari Chiemi、Yonemochi Mayumi、Ikeda Mariko、Hanada Kazuharu、Zhang Kam Y. J.、Shirouzu Mikako
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 30
- DOI
  10.1126/sciadv.abg3147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06575
[Journal Article] Targeting Ras-driven cancer cell survival and invasion through selective inhibition of DOCK12017
- Author(s)
  Tajiri H, Uruno T, Shirai T, Takaya D, Matsunaga S, Setoyama D, Watanabe M, Kukimoto-Niino M, Oisaki K, Ushijima M, Sanematsu F, Honma T, Terada T, Oki E, Shirasawa S, Maehara Y, Kang D, Cote J-F, Yokoyama S, Kanai M, Fukui Y
- Journal Title
  
  Cell Reports
  
  Volume: 19 Issue: 5 Pages: 969-980
- DOI
  10.1016/j.celrep.2017.04.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430115, KAKENHI-PROJECT-15K06987, KAKENHI-PROJECT-16K08627, KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-17H01550
[Presentation] 細胞骨格制御シグナル伝達におけるDOCK複合体の分子構造動態2023
- Author(s)
  柊元（新野）睦子
- Organizer
  日本生化学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H05551
[Presentation] クライオ電子顕微鏡によるDOCK5細胞骨格制御分子複合体の動的構造解析2023
- Author(s)
  柊元睦子
- Organizer
  日本蛋白質科学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H05551

1. Kozasa Tohru (70202059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 村山和隆 (40400452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 宇留野武人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kukimoto Mutsuko 柊元 睦子

柊元 睦子 クキモト ムツコ

Research Projects

Research Products

Co-Researchers

細胞形態形成におけるRhoGEFの多量体化および複合体形成の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of intracellular molecular conformational dynamics in cytoskeletal regulatory signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the structural basis of proteins that regulate cell motilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure and analysis of Ga13-RhoGEF signaling mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of regulatory mechanism of RhoGEF by multidomains cooperationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural insights into the small GTPase specificity of the DOCK guanine nucleotide exchange factors2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK82021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting Ras-driven cancer cell survival and invasion through selective inhibition of DOCK12017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 細胞骨格制御シグナル伝達におけるDOCK複合体の分子構造動態2023

Author(s)

Organizer

Data Source

[Presentation] クライオ電子顕微鏡によるDOCK5細胞骨格制御分子複合体の動的構造解析2023

Author(s)

Organizer

Data Source

Kukimoto Mutsuko 柊元睦子

柊元睦子クキモトムツコ