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IMAI MASAKI  今井 正樹

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Imai Masaki  今井 正樹

IMAI Masaki  今井 正樹

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Researcher Number 30333363
External Links
Affiliation (Current) 2025: 国立健康危機管理研究機構, 国立国際医療研究所, 部長
2025: 東京大学, 医科学研究所, 特任研究員
Affiliation (based on the past Project Information) *help 2025: 国立研究開発法人国立国際医療研究センター, 研究所, 国際ウイルス感染症研究センター 部長
2021 – 2023: 国立研究開発法人国立国際医療研究センター, 研究所, 国際ウイルス感染症研究センター 部長
2015 – 2020: 東京大学, 医科学研究所, 准教授
2013 – 2014: 岩手大学, 農学部, 准教授
2002: 国立感染症研究所, ウイルス第3部, 研究員
2002: National Institute of Infectious Diseases, Department of Virology3, ウイルス第3部, 研究院
2001: 国立感染症研究所, ウイルス1部, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 49060:Virology-related / Basic Section 42020:Veterinary medical science-related / Veterinary medical science / Virology
Except Principal Investigator
Veterinary medical science / Virology
Keywords
Principal Investigator
インフルエンザウイルス / 鳥インフルエンザウイルス / インフルエンザ / COVID-19 / 2種混合ワクチン / 新型コロナウイルス / 感染細胞 / ヘマグルチニン (HA) / 接着 / 好中球 … More / A型インフルエンザウイルス感染 / 蛋白質 / 感染症 / ウィルス / 適応性変異 / ヒト気道上皮細胞 / 適応変異 / H7N9鳥インフルエンザウイルス / 構造安定性 / 季節性インフルエンザウイルス / 酸性pH / 熱安定性 / 感染性 / 膜融合活性 / レセプター特異性 / 安定性 / ヘマグルチニン(HA)蛋白質 … More
Except Principal Investigator
RNAseq / ジミナゼン・アセチュレート / 次世代シークエンス / クローン化 / ジミナゼン / ゲノム解析 / 次世代シークエンサー / DNAマイクロアレイ / 薬剤耐性 / ジミナゼン製剤 / Babesia gibsoni / バベシア症 / trans golgi network / type III membrane protein / cytoplasmic transport / BM2 protein / influenza B virus / 細胞内輸送 / ヌクレオカプシド複合体 / BM2蛋白 / リバースジェネティクス / トランスゴルジネットワーク / 膜蛋白 / インフルエンザBウイルス Less
  • Research Projects

    (7 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (5 People)
  •  高病原性H5N1鳥インフルエンザウイルス感染が引き起こす乳房炎の病態解明Principal Investigator

    • Principal Investigator
      今井 正樹
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      National Center for Global Health and Medicine
  •  COVID-19とインフルエンザに対する2種混合ワクチンの開発Principal Investigator

    • Principal Investigator
      今井 正樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      National Center for Global Health and Medicine
  •  Elucidation of the role of neutrophils in influenza virus infectionPrincipal Investigator

    • Principal Investigator
      IMAI MASAKI
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      National Center for Global Health and Medicine
      The University of Tokyo
  •  Studies on the mechanisms involved in the adaptation of avian influenza viruses to human upper airway epithelial cellsPrincipal Investigator

    • Principal Investigator
      Imai Masaki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Veterinary medical science
    • Research Institution
      The University of Tokyo
  •  Study on the responsible gene for the diminazene-resistant Babesia gibsoni using the DNA microarray.

    • Principal Investigator
      Yamasaki Masahiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Veterinary medical science
    • Research Institution
      Iwate University
  •  Studies on the mechanisms involved in the host range restriction of influenza A virusesPrincipal Investigator

    • Principal Investigator
      Imai Masaki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      The University of Tokyo
      Iwate University
  •  The features and functions of influenza B virus BM2 protein in the process of virus particle formation.

    • Principal Investigator
      ODAGIRI Takato
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      National Institute of Infectious Diseases

All 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation

  • [Journal Article] Characterization of a Feline Influenza A(H7N2) Virus2018

    • Author(s)
      Hatta M, Zhong G, Gao Y, Nakajima N, Fan S, Chiba S, Deering KM, Ito M, Imai M, 他13名
    • Journal Title

      Emerg Infect Dis

      Volume: 24 Issue: 1 Pages: 75-86

    • DOI

      10.3201/eid2401.171240

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08017, KAKENHI-PLANNED-16H06434, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429
  • [Journal Article] A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets2017

    • Author(s)
      Imai Masaki、Watanabe Tokiko et al
    • Journal Title

      Cell Host&Microbe

      Volume: 22 Issue: 5 Pages: 615-626

    • DOI

      10.1016/j.chom.2017.09.008

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08016, KAKENHI-PROJECT-16K08017, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06434
  • [Journal Article] Selection of antigenically advanced variants of seasonal influenza viruses.2016

    • Author(s)
      Li C, Hatta M, Burke DF, Ping J, Zhang Y, Ozawa M, Taft AS, Das SC, Hanson AP, Song J, Imai M, Wilker PR, Watanabe T, Watanabe S, Ito M, Iwatsuki-Horimoto K et al.
    • Journal Title

      Nat Microbiol

      Volume: 23 Issue: 6 Pages: 16058-16058

    • DOI

      10.1038/nmicrobiol.2016.58

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24590786, KAKENHI-PROJECT-16K08016, KAKENHI-PROJECT-16K08017
  • [Journal Article] Risk assessment of recent Egyptian H5N1 influenza viruses2016

    • Author(s)
      Arafa AS, Yamada S, Imai M, Watanabe T et al
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 38388-38388

    • DOI

      10.1038/srep38388

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06434, KAKENHI-PROJECT-16J07228, KAKENHI-PROJECT-24590786, KAKENHI-PROJECT-26460549, KAKENHI-PROJECT-16K08016, KAKENHI-PROJECT-16K08017
  • [Journal Article] Development of high-yield influenza A virus vaccine viruses2015

    • Author(s)
      Ping J, Lopes TJ, Nidom C, Ghedin E, Macken C, Fitch A, Imai M, Maher E, Neumann G & Kawaoka Y
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 8148-8148

    • DOI

      10.1038/ncomms9148

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460581
  • [Journal Article] Identification of Stabilizing Mutations in an H5 HA Influenza Virus Protein.2015

    • Author(s)
      Hanson A, Imai M, Hatta M, McBride R, Imai H, Taft A, Zhong G, Watanabe T, Suzuki Y, Neumann G, Paulson JC, Kawaoka Y.
    • Journal Title

      Journal of Virology

      Volume: 90 Issue: 6 Pages: 2981-2990

    • DOI

      10.1128/jvi.02790-15

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25450422, KAKENHI-PROJECT-25460581
  • [Journal Article] Circulating avian influenza viruses closely related to the 1918 virus have pandemic potential.2014

    • Author(s)
      Watanabe T, Zhong G, Russell CA, Nakajima N, Hatta M, Hanson A, McBride R, Burke DF, Takahashi K, Fukuyama S, Tomita Y, Maher EA, Watanabe S, Imai M, Neumann G, Hasegawa H, Paulson JC, Smith DJ, Kawaoka Y
    • Journal Title

      Cell Host and Microbe

      Volume: 15 Issue: 6 Pages: 692-705

    • DOI

      10.1016/j.chom.2014.05.006

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25450422, KAKENHI-PROJECT-25460581, KAKENHI-PROJECT-26460447
  • [Journal Article] Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.2014

    • Author(s)
      Fan S, Hatta M, Kim JH, Halfmann P, Imai M, Macken CA, Le MQ, Nguyen T, Neumann G, Kawaoka Y
    • Journal Title

      Nature communications

      Volume: 5 Issue: 1 Pages: 5021-5021

    • DOI

      10.1038/ncomms6021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460581
  • [Journal Article] Avian influenza virus transmission to mammals.2014

    • Author(s)
      Herfst S, Imai M, Kawaoka Y , Fouchier RA
    • Journal Title

      Current Topics in Microbiology and Immunology

      Volume: 385 Pages: 137-155

    • DOI

      10.1007/82_2014_387

    • ISBN
      9783319111544, 9783319111551
    • Data Source
      KAKENHI-PROJECT-25460581
  • [Journal Article] Selection on haemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses.2013

    • Author(s)
      Wilker PR, Dinis JM, Starrett G, Imai M, Hatta M, Nelson CW, O'Connor DH, Hughes AL, Neumann G, Kawaoka Y, Friedrich TC
    • Journal Title

      Nature communications

      Volume: 4 Issue: 1 Pages: 2636-2636

    • DOI

      10.1038/ncomms3636

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460581
  • [Journal Article] Characterization of H7N9 influenza A viruses isolated from humans.2013

    • Author(s)
      Watanabe T, Kiso M, Fukuyama S, Nakajima N, Imai M, Yamada S, Murakami S, Yamayoshi S, Iwatsuki-Horimoto K, Sakoda Y, Takashita E, McBride R, Noda T, Hatta M, Imai H, Zhao D, Kishida N, Shirakura M, de Vries RP, Shichinohe S, Okamatsu M, Tamura T, Tomita Y , Fujimoto N, Goto K, Katsura H, Kawakami E, Ishikawa I, Watanabe S, Ito M, Sakai-Tagawa Y, Sugita Y, Uraki R, Yamaji R, Eisfeld AJ, Zhong G, Fan S, Ping J, Maher EA, Hanson A, Uchida Y, Saito T, Ozawa M, Neumann G, Kida H, Odagiri T, Paulson JC, Hasegawa H, Tashiro M, Kawaoka Y
    • Journal Title

      Nature

      Volume: 501(7468) Issue: 7468 Pages: 551-5

    • DOI

      10.1038/nature12392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J01509, KAKENHI-PROJECT-13J02481, KAKENHI-PROJECT-23590145, KAKENHI-PROJECT-24590549, KAKENHI-PROJECT-24590786, KAKENHI-PROJECT-24658245, KAKENHI-PROJECT-25293107, KAKENHI-PROJECT-25450422, KAKENHI-PROJECT-25460581, KAKENHI-PROJECT-25670216
  • [Journal Article] Transmission of influenza A/H5N1 viruses in mammals.2013

    • Author(s)
      Imai M, Herfst S, Sorrell EM, Schrauwen EJ, Linster M, De Graaf M, Fouchier RA, Kawaoka Y
    • Journal Title

      Virus Research

      Volume: 178 Issue: 1 Pages: 15-20

    • DOI

      10.1016/j.virusres.2013.07.017

    • Data Source
      KAKENHI-PROJECT-25460581
  • [Presentation] H7N9鳥インフルエンザウイルスはヒトの間で大流行を起こすのか2019

    • Author(s)
      今井正樹
    • Organizer
      第18回東北臨床感染症研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08017
  • [Presentation] Characterization of a highly pathogenic avian H7N9 influenza virus2018

    • Author(s)
      Masaki Imai
    • Organizer
      20th International Conference on Emerging Infectious Diseases in the Pacific Rim
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08017
  • [Presentation] Characterization of a highly pathogenic avian H7N9 influenza virus2018

    • Author(s)
      Masaki Imai
    • Organizer
      IMSUT-CAS Workshop on Infectious Diseases 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08017
  • [Presentation] インフルエンザウイルスの宿主への適応戦略2017

    • Author(s)
      今井正樹、渡邉登喜子
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-19
    • Data Source
      KAKENHI-PROJECT-16K08017
  • [Presentation] 鳥インフルエンザウイルスの哺乳類間伝播機構2017

    • Author(s)
      今井正樹
    • Organizer
      第31回 インフルエンザ研究者交流の会シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08017
  • [Presentation] Evaluation of efficacy of an inactivated high growth reassortant whole-virus seasonal influenza vaccine in ferret2016

    • Author(s)
      Kishida N, Imai M, Ainai A, Saito R, Nakamura K, Kuwahara T, Fujisaki S, Takashita E, Shirakura M, Kashiwagi Y, Tashiro M, Odagiri T, Watanabe S
    • Organizer
      Options IX for the Control of Influenza
    • Place of Presentation
      米国、シカゴ
    • Year and Date
      2016-08-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08017
  • [Presentation] 空気伝播するH5インフルエンザウイルス2013

    • Author(s)
      今井正樹
    • Organizer
      第127回 宮崎大学農学部獣医学科集談会
    • Place of Presentation
      宮崎大学農学部(宮崎県宮崎市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25460581
  • [Presentation] 中国で発生した鳥インフルエンザA(H7N9)について2013

    • Author(s)
      今井正樹
    • Organizer
      第47回日本ウイルス学会北海道支部会夏季シンポジウム
    • Place of Presentation
      ホテル北乃湯(北海道奈井江町)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25460581
  • 1.  ODAGIRI Takato (80177237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  WATANABE Sinji (30332365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  Yamasaki Masahiro (40322846)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  IWATSUKI-HORIMOTO Kiyoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  渡辺 登喜子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results

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