HASHIMOTO Masahito 橋本雅仁

Researcher Number	30333537
Other IDs
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Affiliation (Current)	2025: 鹿児島大学, 理工学域工学系, 教授
Affiliation (based on the past Project Information) *help	2015 – 2019: 鹿児島大学, 理工学域工学系, 教授 2015: 鹿児島大学, 工学部, 教授 2015: 鹿児島大学, 理工学研究科, 准教授 2014: 鹿児島大学, 理工学研究科, 教授 2011 – 2013: 鹿児島大学, 理工学研究科, 准教授 … More 2007 – 2008: Kagoshima University, 大学院・理工学研究科, 准教授 2005 – 2006: 鹿児島大学, 大学院理工学研究科, 助教授 2004 – 2005: 鹿児島大学, 大学院・理工学研究科, 助教授 2001 – 2003: 朝日大学, 歯学部, 助手 Less
Review Section/Research Field	Principal Investigator Living organism molecular science / Biomolecular chemistry / Morphological basic dentistry Except Principal Investigator Morphological basic dentistry / Bacteriology (including mycology) / Living organism molecular science / Morphological basic dentistry
Keywords	Principal Investigator 自然免疫 / リポ多糖 / 質量分析 / 乳酸菌 / 外膜小胞 / 酢酸菌 / 構造解析 / 微生物 / 発酵食品 / アレルギー … More / 一酸化窒素 / 菌体外多糖 / リポオリゴ糖 / Mesorhizobium loti / 根粒菌 / ミヤコグサ / マメ科植物 / 分離・精製 / Staphylococcus aureus / ペプチドグリカン / リポタイコ酸 / TLR / Pamps / グラム陽性菌 / 歯周炎 / 歯周病 / リピドA / 複合糖質 / 病原因子 / 内毒素 / 歯肉炎 / Prevotella intermedia / 口腔細菌 … More Except Principal Investigator 腸内細菌 / Bacteroides / 免疫沈降 / Protein G / 表層分子 / Prevotella / 菌叢解析 / 腸内細菌科細菌 / IgG結合細菌 / IgG / 潰瘍性大腸炎 / 歯周病細菌 / リポ多糖 / 歯周病関連細菌 / neutralizing antibody / separation and purification / lipoarabinomannan / lipopeptide / lipoprotein / lipoteichoic acid / innate immunity / Gram-positive bacteria / 活性中和抗体 / 分離・精製 / リポアラビノマンナン / リポペプチド / リポプロテイン / リポタイコ酸 / 自然免疫 / グラム陽性菌 / Cytokine / Immunobiological activity / Periodontal disease / Toll-like receptor / Human gingival eptithelial cell / Outer membrane / Treponema medium / Oral treponema / ヒト歯肉上皮細胞 / 菌体表層タンパク質 / 複合糖質画分 / 細胞応答 / サイトカイン / 菌体成分 / Toll様受容体 / 歯肉上皮細胞 / 口腔スピロヘータ / LPS / ＬＰＳ / 細菌 / 歯周病 / 偽膜性大腸炎 / 多糖 / 感染防御 / 共生 / 構造解析 / 莢膜 / Clostridium / 莢膜多糖 / 糖代謝 / 溶菌 / 毒素 / Clostridium difficile / 腸管内常在菌 Less

Analysis of the gut microbe-derived molecular pattern recognized by the serum IgG of ulcerative colitis patients
- Principal Investigator
  
  KUWAHARARA TOMOMI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Kagawa University
Complete analysis of the composition and biosynthesis mechanism of specific O-polysaccharides present in a periodontal pathogen's LPS
- Principal Investigator
  
  SHOJI Mikio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Nagasaki University
Elucidation of immunomodulatory effects of probiotic bacterial componentsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Masahito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Kagoshima University
Role of the sugar metabolism of resident microbiota in the gut homeostasis
- Principal Investigator
  
  KUWAHARA Tomomi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Kagawa University
Biogenesis of sugar moiety of anionic lipopolysaccharide associated with CTD proteins
- Principal Investigator
  
  NAKAYAMA Koji
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Nagasaki University
Separation and functional analysis of allergy inhibitor in fermented foodsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Masahito
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kagoshima University
Studies on rhizobacterial components and their plant immune responsesPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Masahito
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kagoshima University
Structural and functional elucidation of novel immunobiologically active high molecular weight glycoconjugatos from bacterial cell surface
- Principal Investigator
  
  SUDA Yasuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kagoshima University
グラム陽性菌由来自然免疫活性化物質の化学構造に関する研究Principal Investigator
- Principal Investigator
  
  橋本雅仁
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kagoshima University
歯周病原細菌の菌体表層複合糖質の構造学的・免疫分子生物学的研究Principal Investigator
- Principal Investigator
  
  橋本雅仁
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Asahi University
Molecular biological properties of oral treponemes and their outer membrane extracts
- Principal Investigator
  
  OGAWA Tomohiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Asahi University

All 2017 2016 2013 2008 2007 2006 Other

All Journal Article Presentation Patent

[Journal Article] TLR2-stimulating contaminants in glycoconjugate fractons prepared from Bacteroides fragilis.2017
- Author(s)
  Hashimoto M, Waki J, Nakayama-Imaohji H, Ozono M, Hashiguchi S, Kuwahara T.
- Journal Title
  
  Innate Immun
  
  Volume: 23 Issue: 5 Pages: 449-458
- DOI
  10.1177/1753425917714313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08833, KAKENHI-PROJECT-15K00822
[Journal Article] Counterselection employing mutated pheS for markerless genetic deletion in Bacteroides species2016
- Author(s)
  Kino Y, Nakayama-Imaohji H, Fujita M, Tada A, Yoneda S, Murakami K, Hashimoto M, Hayashi T, Okazaki K, Kuwahara T.
- Journal Title
  
  Anaerobe
  
  Volume: 42 Pages: 81-88
- DOI
  10.1016/j.anaerobe.2016.09.004
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460530, KAKENHI-PROJECT-15K00822
[Journal Article] Characterization of a Novel d-Glycero-d-talo-oct-2-ulosonic acid-substituted Lipid A Moiety in the Lipopolysaccharide Produced by the Acetic Acid Bacterium Acetobacter pasteurianus NBRC 3283.2016
- Author(s)
  Hashimoto, M., Ozono, M., Furuyashiki, M., Baba, R., Hashiguchi, S., Suda, Y., Fukase, K., Fujimoto, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 40 Pages: 21184-21194
- DOI
  10.1074/jbc.m116.751271
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05836, KAKENHI-PROJECT-16H01885, KAKENHI-PROJECT-26282211, KAKENHI-PROJECT-26350961
[Journal Article] Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu).2013
- Author(s)
  Hashimoto M, Obara K, Ozono M, Furuyashiki M, Ikeda T, Suda Y, Fukase K, Fujimoto Y, Shigehisa H
- Journal Title
  
  J. Biosci. Bioeng.
  
  Volume: 116 Issue: 6 Pages: 688-696
- DOI
  10.1016/j.jbiosc.2013.05.029
- NAID
  110009687832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510259
[Journal Article] Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu)2013
- Author(s)
  Hashimoto M, Obara K, Ozono M, Furuyashiki M, Ikeda T, Suda Y, Fukase K, Fujimoto Y, Shigehisa H
- Journal Title
  
  J. Biosci. Bioeng
  
  Volume: 116(6) Pages: 688-696
- NAID
  110009687832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510259
[Journal Article] Evidence of immunostimulating lipoprotein co-existing in natural lipoteichoic acid fraction.2007
- Author(s)
  Masahito Hashimoto et al.
- Journal Title
  
  Infection and Immunity 75-4
  
  Pages: 1926-1932
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510179
[Journal Article] Evidence of immunostimulating lipoprotein co-existing in natural lipoteichoic acid fraction.2007
- Author(s)
  Masahito Hashimoto et al.
- Journal Title
  
  Infection and Immunity 75(4)
  
  Pages: 1926-1932
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510179
[Journal Article] Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components.2006
- Author(s)
  Masahito Hashimoto et al.
- Journal Title
  
  International Immunology 18
  
  Pages: 355-362
- NAID
  10020621607
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510179
[Journal Article] Not lipotcichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus.2006
- Author(s)
  Masahito Hashimoto et al.
- Journal Title
  
  The Journal of Immunology 177
  
  Pages: 3162-3169
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17510179
[Journal Article] Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus.2006
- Author(s)
  Masahito Hashimoto et al.
- Journal Title
  
  The Journal of Immunology 177
  
  Pages: 3162-3169
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17510179
[Journal Article] Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components.2006
- Author(s)
  Masahito Hashimoto et al.
- Journal Title
  
  International Immunology 18
  
  Pages: 355-362
- NAID
  10020621607
- Data Source
  KAKENHI-PROJECT-16710160
[Patent] 免疫増強剤及びその製造方法2017
- Inventor(s)
  橋本雅仁
- Industrial Property Rights Holder
  橋本雅仁
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-027138
- Filing Date
  2017-02-16
- Data Source
  KAKENHI-PROJECT-26350961
[Presentation] 酢酸菌由来外膜小胞の免疫刺激能2017
- Author(s)
  橋本雅仁、松元太一、馬場梨沙子、大薗まみ、橋口周平
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-26350961
[Presentation] 酢酸菌由来リポ多糖の構造と生物活性2017
- Author(s)
  橋本雅仁
- Organizer
  かがわ糖質バイオフォーラム複合糖質・糖鎖研究会
- Place of Presentation
  e-とぴあ・かがわ BBスクエア（香川県高松市）
- Invited
- Data Source
  KAKENHI-PROJECT-26350961
[Presentation] 酢酸菌由来リポ多糖の性質とそのリピドＡ構造2016
- Author(s)
  橋本雅仁、隅田泰生、深瀬浩一、藤本ゆかり
- Organizer
  第22回日本エンドトキシン・自然免疫研究会
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-26350961
[Presentation] L-92乳酸菌の免疫システムに及ぼす影響2013
- Author(s)
  橋本雅仁
- Organizer
  環境・生活習慣型アレルギーケアフォーラム「アトピーの現状と乳酸菌によるアトピー改善の可能性」
- Place of Presentation
  東京、品川プリンスホテルアネックスタワー5Fプリンスホール
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-23510259
[Presentation] 黒酢中に含まれる自然免疫活性化リガンドの分離2013
- Author(s)
  橋本雅仁、小原恭子、大薗まみ、古屋舗舞子、池田剛、隅田泰生、深瀬浩一、藤本ゆかり、重久浩
- Organizer
  第19回日本エンドトキシン・自然免疫研究会
- Place of Presentation
  ロイヤルオークホテルスパ&ガーガーデンズ、大津市、滋賀
- Data Source
  KAKENHI-PROJECT-23510259
[Presentation] Immunological and structural studies of components in Japanese traditional vinegar, Kurozu2013
- Author(s)
  Masahito Hashimoto
- Organizer
  Japan-Taiwan Bilateral Workshop on Nano-Science
- Place of Presentation
  Inamori Auditorium, Kagoshima Univ., Kagoshima
- Data Source
  KAKENHI-PROJECT-23510259
[Presentation] Characterization of NO-inducing polysaccharides from Mesorhizobium loti2008
- Author(s)
  Masahito Hashimoto, Keita Tsunemi, Yasuo Suda, Maki Nagata, Ken-Ichi Kucho, Mikiko Abe, Toshiki Uchiumi
- Organizer
  8th European Nitrogen Fixation Conference
- Place of Presentation
  Universitet Gent, Belgium
- Year and Date
  2008-09-01
- Data Source
  KAKENHI-PROJECT-19710188
[Presentation] Studies of NO-inducing glycoconjugates from Mesorhizobium loti2008
- Author(s)
  Masahito Hashimoto, Keita Tsunemi, Yasuo Suda, Maki Nagata, Ken-Ichi Kucho, Mikiko Abe, Toshiki Uchiumi
- Organizer
  BMB2008
- Place of Presentation
  神戸・ポートアイランド
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19710188
[Presentation] 一酸化窒素誘導性Mesorhizobium loti由来リポ多糖の研究2007
- Author(s)
  橋本雅仁,本田大士,梶山健次,隅田泰生,永田真紀,九町健一,阿部美紀子,内海俊樹
- Organizer
  第17回植物微生物研究会
- Place of Presentation
  鹿児島大学
- Year and Date
  2007-09-21
- Data Source
  KAKENHI-PROJECT-19710188
[Presentation] Characterization of NO-inducing lipopolysaccharides from Mesorhizobium loti2007
- Author(s)
  Hashimoto Masahito, Daishi Honda, Kenji Kajiyama, Yasuo Suda, Maki Nagata, Ken-ichi Kucho, Mikiko Abe, Toshiki Uchiumi
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19710188
[Presentation] Characterization of NO-inducing Iipopolysaccharides from Mesorhzobium loti.2007
- Author(s)
  橋本雅仁, 他7名
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19710188
[Presentation] L-92乳酸菌の免疫システムに及ぼす影響
- Author(s)
  橋本雅仁
- Organizer
  環境・生活習慣型アレルギーケアフォーラム
- Place of Presentation
  東京都品川区　品川プリンスホテル
- Invited
- Data Source
  KAKENHI-PROJECT-23510259
[Presentation] Immunological and structural studies of components in Japanese traditional vinegar, Kurozu
- Author(s)
  Masahito Hashimoto
- Organizer
  Japan-Taiwan Bilateral Workshop on Nano-Science 2013
- Place of Presentation
  鹿児島市　鹿児島大学
- Data Source
  KAKENHI-PROJECT-23510259
[Presentation] 黒酢中に含まれる自然免疫活性化リガンドの分離
- Author(s)
  橋本雅仁、小原恭子、大薗まみ、古屋舗舞子、池田剛、隅田泰生、深瀬浩一、藤本ゆかり、重久浩
- Organizer
  第19回日本エンドトキシン・自然免疫研究会
- Place of Presentation
  大津市　ロイヤルオークホテル
- Data Source
  KAKENHI-PROJECT-23510259

1. KUWAHARA Tomomi (60263810)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. NAKAYAMA Koji (80150473)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SHOJI Mikio (10336175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SUDA Yasuo (70179282)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 今大路治之 (80294669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OGAWA Tomohiko (80160761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ASAI Yasuyuki (30329487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山本浩代 (50329497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 石川秀樹 (30351795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YUKITAKE Hideharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中山治之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 深瀬浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASHIMOTO Masahito 橋本 雅仁

Research Projects

Research Products

Co-Researchers

Analysis of the gut microbe-derived molecular pattern recognized by the serum IgG of ulcerative colitis patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Complete analysis of the composition and biosynthesis mechanism of specific O-polysaccharides present in a periodontal pathogen's LPS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of immunomodulatory effects of probiotic bacterial componentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of the sugar metabolism of resident microbiota in the gut homeostasis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biogenesis of sugar moiety of anionic lipopolysaccharide associated with CTD proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Separation and functional analysis of allergy inhibitor in fermented foodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on rhizobacterial components and their plant immune responsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural and functional elucidation of novel immunobiologically active high molecular weight glycoconjugatos from bacterial cell surface

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

グラム陽性菌由来自然免疫活性化物質の化学構造に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

歯周病原細菌の菌体表層複合糖質の構造学的・免疫分子生物学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biological properties of oral treponemes and their outer membrane extracts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] TLR2-stimulating contaminants in glycoconjugate fractons prepared from Bacteroides fragilis.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Counterselection employing mutated pheS for markerless genetic deletion in Bacteroides species2016

Author(s)

Journal Title

DOI

Data Source

HASHIMOTO Masahito 橋本雅仁