AKAHORI Masakazu 赤堀正和

… Alternative Names

赤堀正和アカホリマサカズ

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Researcher Number	30343544
Affiliation (based on the past Project Information) *help	2013 – 2014: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員 2011: 独立行政法人国立病院機構東京医療センター(臨床研究センター), 分子細胞生物学研究部, 流動研究員 2011: 独立行政法人国立病院機構東京医療センター臨床研究センター, 分子細胞生物学研究部, 研究員 2010: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員 2008 – 2009: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 流動研究員 … More 2006: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 視覚研究部細胞分子生物学研究室, 流動研究員 2005: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 視覚研究部細胞分子生物学研究室, 研究員 2004: 慈恵医大, 医学部, 助手 2002 – 2003: 東京慈恵会医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Ophthalmology / Endocrinology
Keywords	Principal Investigator 細胞・組織 / 動物 / 遺伝子 / 網膜 / 遺伝性疾患 / エクソーム解析 / モデル動物 / OPTN / 緑内障モデル動物 / 開放隅角緑内障 … More / 糖尿病 / SKG-II-SF細胞 / インスリン産生細胞 / ES細胞 Less

遺伝性網膜疾患におけるエクソームシーケンスを用いた網羅的遺伝子解析法の確立Principal Investigator
- Principal Investigator
  
  赤堀正和
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
Establish model animal for AMD and Analysis of pathogenic mechanism of AMDPrincipal Investigator
- Principal Investigator
  
  AKAHORI Masakazu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  独立行政法人国立病院機構東京医療センター(臨床研究センター)
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
Overexpression of HtrA1 leads to retinal abnormality in micePrincipal Investigator
- Principal Investigator
  
  AKAHORI Masakazu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
OPTN変異による正常眼圧緑内症の発症機序の解明Principal Investigator
- Principal Investigator
  
  赤堀正和
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
ES細胞からインスリン産生細胞への新しい分化誘導法の開発Principal Investigator
- Principal Investigator
  
  赤堀正和
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Jikei University School of Medicine

All 2014 2013 2011 2010 2009 2006

All Journal Article Presentation Book

[Book] Retina Medicine2014
- Author(s)
  赤堀正和、岩田岳
- Total Pages
  4
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-25462744
[Journal Article] Novel C8orf37 Mutations in Patients with Early-onset Retinal Dystrophy, Macular Atrophy, Cataracts, and High Myopia.2014
- Author(s)
  Katagiri S, Hayashi T, Yoshitake K, Akahori M, Ikeo K, Gekka T, Tsuneoka H, Iwata T.
- Journal Title
  
  Ophthalmic Genetics
  
  Volume: 12 Pages: 1-8
- DOI
  10.3109/13816810.2014.949380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462744, KAKENHI-PROJECT-25462738
[Journal Article] Whole-exome sequencing identifies a novel ALMS1 mutation (p.Q2051X) in two Japanese brothers with Alström syndrome.2014
- Author(s)
  Katagiri S, Yoshitake K, Akahori M, Hayashi T, Furuno M, Nishino J, Ikeo K, Tsuneoka H, Iwata T.
- Journal Title
  
  Molecular Vision
  
  Volume: 19 Pages: 2393-2406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462744
[Journal Article] Autosomal recessive cone-rod dystrophy associated with compound heterozygous mutations in the EYS gene.2014
- Author(s)
  Katagiri S, Akahori M, Hayashi T, Yoshitake K, Gekka T, Ikeo K, Tsuneoka H, Iwata T.
- Journal Title
  
  Doc Ophthalmol.
  
  Volume: 128(3) Issue: 3 Pages: 211-217
- DOI
  10.1007/s10633-014-9435-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370098, KAKENHI-PROJECT-25462738, KAKENHI-PROJECT-25462744
[Journal Article] Lack of association of LOXL1 gene variants in Japanese patients with central retinal vein occlusion without clinically detectable pseudoexfoliation material deposits.2014
- Author(s)
  Tanito M, Hara K, Akahori M, Harata A, Itabashi T, Takai Y, Kaidzu S, Ohira A, Iwata T.
- Journal Title
  
  Acta Ophthalmologica
  
  Volume: 印刷確定 Issue: 3
- DOI
  10.1111/aos.12534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462744, KAKENHI-PROJECT-26293377, KAKENHI-PROJECT-26670762
[Journal Article] Whole exome analysis identifies frequent CNGA1 mutations in Japanese population with autosomal recessive retinitis pigmentosa2014
- Author(s)
  Katagiri S, Akahori M, Sergeev Y, Yoshitake K, Ikeo K, Furuno M, Hayashi T, Kondo M, Ueno S, Tsunoda K, Shinoda K, Kuniyoshi K, Tsurusaki Y, Matsumoto N, Tsuneoka H, Iwata T.
- Journal Title
  
  Plos One
  
  Volume: 9（9） Issue: 9 Pages: e108721-e108721
- DOI
  10.1371/journal.pone.0108721
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118007, KAKENHI-PROJECT-24249019, KAKENHI-PROJECT-25462744, KAKENHI-PROJECT-25860915, KAKENHI-PROJECT-26293377, KAKENHI-PROJECT-26462674, KAKENHI-PROJECT-26670762
[Journal Article] Stargardt disease with preserved central vision : identification of a putative novel mutation in ATP-binding cassette transporter gene2011
- Author(s)
  Fujinami K, Akahori M
- Journal Title
  
  Acta Ophthalmologica
  
  Volume: 89(3) Pages: 297-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791704
[Journal Article] Dominant mutations in RP1L1 are responsible for occult macular dystrophy2010
- Author(s)
  Akahori M, Tsunoda K
- Journal Title
  
  American Journal of Human Genetics
  
  Volume: 87(3) Pages: 424-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791704
[Journal Article] Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice2010
- Author(s)
  Chi ZL, Akahori M
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 19(13) Pages: 2606-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791704
[Journal Article] Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population.2009
- Author(s)
  Goto A, Akahori M
- Journal Title
  
  J Ocul Biol Dis Infor. 2
  
  Pages: 164-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791291
[Journal Article] Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population.2009
- Author(s)
  Goto A, Akahori M, Okamoto H, Minami M, Terauchi N, Haruhata Y, Obazawa M, Noda T, Honda M, Mizota A, Tanaka M, Hayashi T, Tanito M, Ogata N, Iwata T.
- Journal Title
  
  J Ocul Biol Dis Infor. 2(4)
  
  Pages: 64-175
- Data Source
  KAKENHI-PROJECT-20791291
[Journal Article] 正常眼圧力緑内障マウスの作製とその病理学的及び分子生物学的解析2006
- Author(s)
  岩田岳, 赤堀正和, 皆見政好, 尾羽澤実, スタニスラブトマレフ, 中矢直樹, 三宅養三
- Journal Title
  
  日本眼科学会雑誌 110巻臨増
  
  Pages: 138-138
- Data Source
  KAKENHI-PROJECT-17791267
[Presentation] 網膜疾患におけるExome解析2013
- Author(s)
  赤堀正和、岩田岳
- Organizer
  NGS現場の会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25462744
[Presentation] オカルト黄斑ジストロフィー(Occult Macular Dystrophy)の原因遺伝子解明2011
- Author(s)
  赤堀正和
- Organizer
  第115回日本眼科学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22791704
[Presentation] 加齢黄斑変性医療に必要なゲノム学を理解しよう2011
- Author(s)
  赤堀正和
- Organizer
  第65回日本臨床眼科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22791704
[Presentation] 加齢黄斑変性症およびポリープ状脈絡膜血管症における全ゲノム関連解析2010
- Author(s)
  赤堀正和その他、
- Organizer
  感覚器シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22791704
[Presentation] Association Study on AMD in Japanese Patients and Characterization of HtrAl Transgenic Mice2009
- Author(s)
  赤堀正和
- Organizer
  Association for Research in Vision and Ophthalmology 2009 Annual Meeting
- Place of Presentation
  Fort Lauderdale, US
- Year and Date
  2009-05-07
- Data Source
  KAKENHI-PROJECT-20791291

1. 池尾一穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 松本直通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKAHORI Masakazu 赤堀 正和

赤堀 正和 アカホリ マサカズ

Research Projects

Research Products

Co-Researchers

遺伝性網膜疾患におけるエクソームシーケンスを用いた網羅的遺伝子解析法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establish model animal for AMD and Analysis of pathogenic mechanism of AMDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Overexpression of HtrA1 leads to retinal abnormality in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

OPTN変異による正常眼圧緑内症の発症機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ES細胞からインスリン産生細胞への新しい分化誘導法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Retina Medicine2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Novel C8orf37 Mutations in Patients with Early-onset Retinal Dystrophy, Macular Atrophy, Cataracts, and High Myopia.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Whole-exome sequencing identifies a novel ALMS1 mutation (p.Q2051X) in two Japanese brothers with Alström syndrome.2014

Author(s)

Journal Title

Data Source

[Journal Article] Autosomal recessive cone-rod dystrophy associated with compound heterozygous mutations in the EYS gene.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lack of association of LOXL1 gene variants in Japanese patients with central retinal vein occlusion without clinically detectable pseudoexfoliation material deposits.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Whole exome analysis identifies frequent CNGA1 mutations in Japanese population with autosomal recessive retinitis pigmentosa2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stargardt disease with preserved central vision : identification of a putative novel mutation in ATP-binding cassette transporter gene2011

Author(s)

Journal Title

Data Source

[Journal Article] Dominant mutations in RP1L1 are responsible for occult macular dystrophy2010

Author(s)

Journal Title

Data Source

[Journal Article] Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice2010

Author(s)

Journal Title

Data Source

[Journal Article] Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population.2009

Author(s)

Journal Title

Data Source

AKAHORI Masakazu 赤堀正和

赤堀正和アカホリマサカズ