Hakata Yoshiyuki 博多義之

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HAKATA Yoshiyuki 博多義之

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Researcher Number	30344500
Other IDs
Affiliation (Current)	2023: 近畿大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2014 – 2023: 近畿大学, 医学部, 講師 2009 – 2014: Kinki University, 医学部, 助教 2002 – 2004: 北海道大学, 遺伝子病制御研究所, 助手
Review Section/Research Field	Principal Investigator Virology / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Biological Sciences / Virology / Experimental pathology / Virology / Basic Section 49060:Virology-related / Basic Section 49030:Experimental pathology-related
Keywords	Principal Investigator HIV-1 / Rac2 / 感染抵抗性遺伝子 / ウイルス / 感染抵抗性因子 / HTLV-1 / RNA / 核外輸送 / Rex / CRM1 … More / 多量体化 / 発現制御 / 転写後制御 / 転写後調節 / HIV-1感染抵抗性遺伝子 / CCR5 / CCL5 / CCL3/4 / TNF / IL6 / CCL3 / CCL4 / SNPs / rac2 / 感染制御 / HIV / オートファジー / Vpr / Retrovirus / MuLV / APOBEC3 / Gag-Pol autoprocessing / Gag assembly / retrovirus … More Except Principal Investigator APOBEC3 / レトロウイルス / HTLV-1 / CRM1 / HIV / Rex / ラット / 宿主因子 / 中和抗体 / Bリンパ球 / HIV-1 / 感染抵抗性 / 遺伝子多型 / 胚中心 / 宿主遺伝子 / Rev / ヒトレトロウイルス / RNA / 輸送 / RNA輸送 / 多量体化 / 感染モデル / トランスジェニックラット / エイズワクチン / 治療法 / 個体 / 遺伝子発現 / スプライシング / 翻訳効率 / 進化 / 複製制御 / シチジンデアミナーゼ / 発現制御 / エキソン / 単一塩基多型 / 活性化 / 発がん制御 / 内在性レトロウイルス / 乳癌 / リンパ腫 / 白血病 / 体細胞高頻度突然変異 / Tリンパ球 / 胸腺 / AID / クラススイッチ / 標的細胞 / 持続感染 / TLR7 / 感染動物モデル / rat / Infection animal model / 複製阻害 / プロテアーゼ / 粒子成熟 / Gag-Pol前駆体 / 複製制限 / タンパク質相互作用 / プロセシング / マウスレトロウイルス / ウイルス / タンパク質間相互作用 / ヒト免疫不全ウイルス / ウイルスプロテアーゼ / タンパク質プロセシング / 分子間相互作用 / ゲノム編集 / ノックインマウス / 免疫組織化学 / 細胞質 / タンパク質局在 / 細胞内局在 / 骨髄 / Bリンパ腫 / 発症因子 Less

抗ウイルス遺伝子産物により誘導される細胞内ウイルスRNA分解の新機構Principal Investigator
- Principal Investigator
  
  博多義之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kindai University
Mechanisms of B-lymphomagenesis in the absence of APOBEC3 cytidine deaminase
- Principal Investigator
  
  宮澤正顯
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kindai University
Identification of host genes that regulate neutralizing antibody production upon retrovirus infections and their mechanisms of action
- Principal Investigator
  
  Miyazawa Masaaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kindai University
Designing novel protease inhibitors based on the interference of mouse APOBEC3 with retroviral Gag-Pol autocatalysis
- Principal Investigator
  
  MIYAZAWA Masaaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Kindai University
Molecular mechanism of APOBEC3-mediated inhibition on Gag-Pol autoprocessingPrincipal Investigator
- Principal Investigator
  
  HAKATA Yoshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kindai University
Autophagy regulation by HIV-1 VprPrincipal Investigator
- Principal Investigator
  
  HAKATA Yoshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kinki University
Mechanisms of regulation of host immune responses by retrovirus-restricting enzyme APOBEC3
- Principal Investigator
  
  MIYAZAWA Masaaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Kinki University
Molecular mechanism of anti-HIV-1 activity mediated by Rac2Principal Investigator
- Principal Investigator
  
  HAKATA Yoshiyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kinki University
The role of mouse APOBEC3 in the regulation of endogenous retrovirus
- Principal Investigator
  
  KAWAHARA Sachiyo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kinki University
Regulation of APOBEC3 gene expression and its transcript splicing
- Principal Investigator
  
  MIYAZAWA Masaaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Kinki University
Analysis of rac2 gene expression and its role on anti-HIV-1 restrictionPrincipal Investigator
- Principal Investigator
  
  HAKATA Yoshiyuki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kinki University
トランスジェニックラット感染モデルを用いたエイズワクチン・治療法開発
- Principal Investigator
  
  志田壽利
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
ヒトレトロウイルスのRNA輸送複合体の形成と制御
- Principal Investigator
  
  志田壽利
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
ヒトT細胞白血病ウイルスのRNA核外輸送機構の解明Principal Investigator
- Principal Investigator
  
  博多義之
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Hokkaido University
HIV/HTLV-1高感受性のヒトCRM1を発現するトランスジェニックラット
- Principal Investigator
  
  SHIDA Hisatoshi
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Construction of a transgenic rat model, which is highly sensitive to HTLV-1 infection
- Principal Investigator
  
  SHIDA Hisatoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  HOKKAIDO UNIVERSITY

All 2022 2020 2019 2018 2017 2016 2015 2014 2012 2011 2010 2009 2006

All Journal Article Presentation

[Journal Article] Distinctive high expression of antiretroviral APOBEC3 protein in mouse germinal center B cells2022
- Author(s)
  Shota Tsukimoto, Yoshiyuki Hakata, Sachiyo Tsuji-Kawahara, Takuji Enya, Tetsuo Tsukamoto, Seiya Mizuno, Satoru Takahashi, Shinichi Nakao and Masaaki Miyazawa
- Journal Title
  
  Viruses
  
  Volume: 14 Pages: 832-832
- DOI
  10.3390/v14040832
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03481
[Journal Article] Deaminase-Independent Mode of Antiretroviral Action in Human and Mouse APOBEC3 Proteins2020
- Author(s)
  Hakata Yoshiyuki、Miyazawa Masaaki
- Journal Title
  
  Microorganisms
  
  Volume: 8 Pages: 1976-1976
- DOI
  10.3390/microorganisms8121976
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03481
[Journal Article] Intracellular delivery of a peptide nucleic acid-based hybrid of an autophagy-inducing peptide with a cell-penetrating peptide.2020
- Author(s)
  Hakata Yoshiyuki、Ishikawa Suzuka、Ohtsuki Takashi、Miyazawa Masaaki、Kitamatsu Mizuki
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 18 Pages: 1978-1986
- DOI
  10.1039/c9ob02559f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03481, KAKENHI-PROJECT-18H02090
[Journal Article] Mouse APOBEC3 interferes with autocatalytic cleavage of murine leukemia virus Pr180gag-pol precursor and inhibits Pr65gag processing2019
- Author(s)
  Hakata Yoshiyuki、Li Jun、Fujino Takahiro、Tanaka Yuki、Shimizu Rie、Miyazawa Masaaki
- Journal Title
  
  PLOS Pathogens
  
  Volume: 15
- DOI
  10.1371/journal.ppat.1008173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03481
[Journal Article] A Leucine Zipper-based Peptide Hybrid Delivers Functional Nanog Protein inside the Cell Nucleus2019
- Author(s)
  Yoshiyuki Hakata, Hiroyuki Michiue, Takashi Ohtsuki, Masaaki Miyazawa and Mizuki Kitamatsu
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 29 Pages: 878-881
- DOI
  10.1016/j.bmcl.2019.02.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05199, KAKENHI-PROJECT-16K05856, KAKENHI-PROJECT-16K08821, KAKENHI-PROJECT-18K07324, KAKENHI-PROJECT-18K08944, KAKENHI-PROJECT-19H03481
[Journal Article] Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance2016
- Author(s)
  Takamura, S., H. Yagi, Y. Hakata, C. Motozono, S. R. McMaster, T. Masumoto, M. Fujisawa, T. Chikaishi, J. Komeda, J. Itoh, M. Umemura, A. Kyusai, M. Tomura, T. Nakayama, D. L. Woodland, J. E. Kohlmeier, and M. Miyazawa
- Journal Title
  
  J Exp Med.
  
  Volume: 213 Pages: 3057-3073
- DOI
  10.1084/jem.20160938
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01268, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-16H05199, KAKENHI-PROJECT-15K19116, KAKENHI-PROJECT-16K08409, KAKENHI-PROJECT-16K08821, KAKENHI-PROJECT-16K08850
[Journal Article] Functional polymorphisms and molecular evolution of mouse APOBEC32016
- Author(s)
  宮澤正顯，博多義之，武田英里，李君，河原佐智代
- Journal Title
  
  生化学
  
  Volume: 88 Issue: 5 Pages: 582-592
- DOI
  10.14952/SEIKAGAKU.2016.880582
- ISSN
  0037-1017
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01268, KAKENHI-PROJECT-16H05199, KAKENHI-PROJECT-16K08749
[Journal Article] A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells.2015
- Author(s)
  Hakata, Y., S. Tsuchiya, H. Michiue, T. Ohtsuki, H. Matsui, M. Miyazawa, and M. Kitamatsu
- Journal Title
  
  Chem. Commun.
  
  Volume: 51 Pages: 413-416
- DOI
  10.1039/c4cc07459a
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390116, KAKENHI-PROJECT-24390293, KAKENHI-PROJECT-24791502, KAKENHI-PROJECT-25282232, KAKENHI-PROJECT-25410181, KAKENHI-PROJECT-25460573, KAKENHI-PROJECT-25560224, KAKENHI-PUBLICLY-26107711
[Journal Article] Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest.2014
- Author(s)
  Hakata, Y., M. Miyazawa, and N. R. Landau
- Journal Title
  
  Virology Journal
  
  Volume: 11 Pages: 108-108
- DOI
  10.1186/1743-422x-11-108
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390116, KAKENHI-PROJECT-25460573
[Journal Article] Two geneticdeterminants acquired late in Mus evolution regulate the inclusion of exon5, which alters mouse APOBEC3 translation efficiency2012
- Author(s)
  Li, J., Y. Hakata, E. Takeda, Q. Liu, Y. Iwatani, C. A. Kozak, M. Miyazawa
- Journal Title
  
  PLoS Pathog
  
  Volume: 8
- DOI
  10.1371/journal.ppat.1002478
- NAID
  120006985441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390143, KAKENHI-PROJECT-21590525, KAKENHI-PROJECT-22590352, KAKENHI-PROJECT-23790510
[Journal Article] Nuclear and cytoplasmic effects of human CRM1 on HIV-1 production in rat cells.2011
- Author(s)
  Mika Nagai-Fukataki, Takashi Ohashi, Iwao Hashimoto, Tominori Kimura, Yoshiyuki Hakata, Hisatoshi Shida
- Journal Title
  
  Genes to Cells 16
  
  Pages: 203-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790450
[Journal Article] Two genetic determinants acquired late in mus evolution regulate the inclusion of exon 5,which alters mouse APOBEC3 translation efficiency2011
- Author(s)
  Li J, Hakata Y, Takeda E, Liu Q, Iwatani Y, Kozak CA, Miyazawa M
- Journal Title
  
  PLoS Pathog
  
  Volume: 8(1)
- NAID
  120006985441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590352
[Journal Article] Nuclear and cytoplasmic effects of human CRM1 on HIV-1 production in rat cells2011
- Author(s)
  Mika Nagai-Fukataki, Takashi Ohashi, Iwao Hashimoto, Tominori Kimura, Yoshiyuki Hakata, Hisatoshi Shida
- Journal Title
  
  Genes to Cells
  
  Volume: 16 Pages: 203-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790450
[Journal Article] Deaminase-Independent Inhibition of Parvoviruses by the APOBEC3A Cytidine Deaminase2009
- Author(s)
  Inigo Narvaiza, Daniel C.Linfesty, Benjamin N.Greener, Yoshiyuki Hakata, David J.Pintel, Eric Logue, Nathaniel R.Landau, Matthew D.Weitzman.
- Journal Title
  
  PLoS Pathogens 5(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790450
[Journal Article] CRM1, an RNA transporter, is a major species-specific restriction factor of human T cell leukemia virus type 1(HTLV-1)in rat cells. Microbes and Infection.2006
- Author(s)
  Zhang, X, Hakata, Y, Tanaka, Y, Shida,H.
- Journal Title
  
  Microbes and Infection In Press
- Data Source
  KAKENHI-PROJECT-16017205
[Presentation] Physiological tissue and subcellular localization of APOBEC3 protein revealed by the development of FLAG knock-in mice2019
- Author(s)
  Masaaki Miyazawa, Shota Tsukimoto, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, and Yoshiyuki Hakata
- Organizer
  The 31st International Workshop on Retroviral Pathogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03481
[Presentation] Mouse APOBEC3 interferes with proteolytic autoprocessing of Gag-Pol polyprotein and inhibits Gag processing2018
- Author(s)
  Yoshiyuki Hakata, Jun Li, Takahiro Fujino, Yuki Tanaka, Rie Shimizu, and Masaaki Miyazawa
- Organizer
  Retropath 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08821
[Presentation] Mouse APOBEC3 interferes with proteolytic autoprocessing of Gag-Pol polyprotein and inhibits Gag processing.2018
- Author(s)
  Yoshiyuki Hakata, Jun Li, Takahiro Fujino, Yuki Tanaka, Rie Shimizu, and Masaaki Miyazawa
- Organizer
  The 30th International Workshop on Retroviral Pathogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05199
[Presentation] Mouse APOBEC3 disrupts proteolytic autoprocessing of retroviral Gag-Pol precursors through direct binding to the protease domain2017
- Author(s)
  Masaaki Miyazawa, Yoshiyuki Hakata, Jun Li, Takahiro Fujino, and Yuki Tanaka
- Organizer
  The 29th International Workshop on Retroviral Pathogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05199
[Presentation] HIV-1 Vpr has two distinct functions on autophagy regulation2015
- Author(s)
  博多　義之
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  Fukuoka international congress center
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25460573
[Presentation] Vpr依存的G2期停止におけるVprと宿主因子との分子間相互作用2012
- Author(s)
  博多義之
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-23790510
[Presentation] Vpr依存的G2期停止におけるVprと宿主因子との分子間相互作用2012
- Author(s)
  博多義之
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  大阪市大阪国際会議場
- Data Source
  KAKENHI-PROJECT-22590352
[Presentation] Functional consequences of mouse APOBEC3 gene polymorphisms and multiple genetic factors that influence the production of virus-neutralizing antibodies in Friend virus-infected mice2011
- Author(s)
  Miyazawa, M., S. Tsuji-Kawahara, Y. Hakata, J. Li, E. Takeda, and C. Ishihara
- Organizer
  The 23rd Workshop on Retroviral Pathogenesis
- Place of Presentation
  Montpellier, France
- Data Source
  KAKENHI-PROJECT-23790510
[Presentation] Rac2が発揮する抗HIV-1活性の分子機序2010
- Author(s)
  博多義之(発表演者)
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島県あわぎんホール
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-21790450
[Presentation] Rac2が発揮する抗HIV-1活性の分子機序2010
- Author(s)
  博多義之
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島県徳島市(あわぎんホール)
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-21790450
[Presentation] Rac2が発揮する抗HIV-1活性の分子機構2010
- Author(s)
  Hakata Y
- Organizer
  第58回日本ウイルス学会
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-22590352

1. MIYAZAWA Masaaki (60167757)

# of Collaborated Projects: 8 results

# of Collaborated Products: 16 results
2. SHIDA Hisatoshi (00144395)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. KAWAHARA Sachiyo (60297629)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. YASUDA Jiro (10282518)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKAMURA Shiki (90528564)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 山田雅巳 (10322851)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KIDOKORO Minoru (00370958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大橋貴 (10282774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 塚本徹雄 (80750223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 月本翔太 (40790762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MICHIUE Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. IWATANI Yasumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. TOMURA Michio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 松井秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 大槻高史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 北松瑞生

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 中山俊憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 本園千尋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 八木秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 辻佐智代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hakata Yoshiyuki 博多 義之

HAKATA Yoshiyuki 博多 義之

Research Projects

Research Products

Co-Researchers

抗ウイルス遺伝子産物により誘導される細胞内ウイルスRNA分解の新機構Principal Investigator

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Molecular mechanism of APOBEC3-mediated inhibition on Gag-Pol autoprocessingPrincipal Investigator

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Autophagy regulation by HIV-1 VprPrincipal Investigator

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Molecular mechanism of anti-HIV-1 activity mediated by Rac2Principal Investigator

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Analysis of rac2 gene expression and its role on anti-HIV-1 restrictionPrincipal Investigator

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ヒトT細胞白血病ウイルスのRNA核外輸送機構の解明Principal Investigator

Principal Investigator

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Research Field

Hakata Yoshiyuki 博多義之

HAKATA Yoshiyuki 博多義之