KIMURA Ken-ichi 木村賢一

Researcher Number	30344625
Other IDs	https://orcid.org/0000-0002-4344-2525
Affiliation (Current)	2025: 岩手大学, 農学部, 嘱託教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 岩手大学, 農学部, 教授 2010 – 2011: 岩手大学, 農学部, 教授 2009: Iwate University, 農学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 38040:Bioorganic chemistry-related / Applied biochemistry Except Principal Investigator Basic Section 08030:Family and consumer sciences, and culture and living-related / Basic Section 38030:Applied biochemistry-related / Applied biochemistry
Keywords	Principal Investigator Kuji amber / Saccharomyces cerevisiae / C2C12　cells / H4IIE cells / Spirolactone / Chemical space / アッセイ系 / 単離精製 / 抗アレルギー / ユビキチンリガーゼ … More / 中国撫順産琥珀 / コーパル / RBL-2H3細胞 / rsp5A401E株 / kujigamberol / 遺伝子変異酵母株 / 久慈産琥珀 / Chemical Bioligy / mutant yeast / seco-kujigamberol / Chemiical Biology / Social implementation / Anti-allergy / Spanish amber / Mutant yeast / seco-Kujigamberol / Kujigamberol / Benzophomopsin A / Anthracobic acid / Eremoxylarine / isothiocyanate / benzophomopsin A / anthracobic acid A / eremoxylarin A / phenotype / Ca^<2+>-signal transduction / calcineurin / GSK-3β / pisiferdiol / falcarindiol / 9-(Methylsulfinyl) hexyl isothocyanate / bemzophomopsin A / Ca^<2+>-signaling / Saccharomyces cerevisiae (zds1Δerg3Δpdr1/3Δ) … More Except Principal Investigator allantopyrone A / シグナル伝達 / isopanduratin A / ICAM-1 / HIF-1α / NF-κB / バイオプローブ / 低酸素応答 / 炎症性サイトカイン / 健康機能性 / 化学分類 / 成分育種 / 山菜 / フキ属 / ポリアセチレン化合物 / ウコギ科植物 / セリ科植物 / 糖新生 / インスリン / GSK-3β / 機能性物質 / Falcarindiol / アシアチン酸 / Eomesodermin / トリテルペノイド / IKK-16 / α-conidendrin / Allantopyrone A / Kujigamberol / Cucurbitacin B / Isopanduratin A / Ostruthin / IFN-γ / TNF-α / RelB / RelA / LTβ / TNFレセプター1 / キナクリン / オイデスマン誘導体 / 薬理学 / 生理活性 / asiatic acid / 4-hydroxypanduratin A / 4-O-methylascochlorin / kujigamberol / 糖鎖修飾 / 情報伝達 Less

Integrated study on amber's unique chemical space and diverse biological activitiesPrincipal Investigator
- Principal Investigator
  
  木村賢一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Iwate University
Design of functionality and safety by molecular bleeding in Petasites japonicus
- Principal Investigator
  
  上杉祥太
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Iwate Biotechnology Research Center
食材ポリアセチレン化合物による肝細胞エネルギー代謝制御機構の統合的解析
- Principal Investigator
  
  吉田潤
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Iwate Medical University
Integrated analysis of chemical reaction products in Cretaceous amber and their biological activityPrincipal Investigator
- Principal Investigator
  
  KIMURA Ken-ichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Iwate University
Molecular mechanisms of bioprobes targeting inflammatory reaction and hypoxic respose
- Principal Investigator
  
  TAKAO KATAOKA
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Kyoto Institute of Technology
Elucidation of molecular mechanisms of bioprobes on signaling pathways of inflammatory responses and hypoxic responses
- Principal Investigator
  
  KATAOKA Takao
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Kyoto Institute of Technology
Studies on molecular targets of new biological compounds having activity against the mutant yeast involving calcium signalingPrincipal Investigator
- Principal Investigator
  
  KIMURA Ken-ichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Iwate University

[Book] BIOACTIVE COMPOUNDS from NATURAL SOURCES (Second Edition) Edited by Corrado Tringali, Chapter 16. Endophytic microorganisms as a source of bioactive compounds2012
- Author(s)
  Shiono, Y., Kimura, K.
- Publisher
  Taylor & Francis
- Data Source
  KAKENHI-PROJECT-21580108
[Book] 16 Endophytic microorganisms as a source of bioactive compounds, Bioactive Compounds from Natural sources (2nd Edition), Edited by Corrado Tringali, Edited by Corrado Tringali2012
- Author(s)
  Shiono, Y. and Kimura, K.
- Publisher
  Taylor & Francis
- Data Source
  KAKENHI-PROJECT-21580108
[Journal Article] 3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation2023
- Author(s)
  Usukhbayar Narandulam、Takano Yukie、Uesugi Shota、Muroi Makoto、Osada Hiroyuki、Kimura Ken-ichi
- Journal Title
  
  Free Radical Research
  
  Volume: 57 Issue: 3 Pages: 208-222
- DOI
  10.1080/10715762.2023.2229005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-23K02000, KAKENHI-PROJECT-22H04922
[Journal Article] Golden berry leaf extract containing withanolides suppresses TNF-α and IL-17 induced IL-6 expression in HeLa Cells2023
- Author(s)
  Yano A, Yuki S, Shiraishi A, Hakozaki M, Kanno Y, Kimura K, Uesugi S
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 87 Issue: 9 Pages: 972-980
- DOI
  10.1093/bbb/zbad070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K02000, KAKENHI-PROJECT-21K05433
[Journal Article] 3,6-Epidioxy-1,10-bisaboladiene and sulfasalazine synergistically induce ferroptosis-like cell death in human breast cancer cell lines2023
- Author(s)
  Usukhbayar N, Uesugi S, Kimura K
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 87 Issue: 11 Pages: 1336-1344
- DOI
  10.1093/bbb/zbad117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K02000
[Journal Article] Synthesis and structure?activity relationship of kujigamberol B, a dinorlabdane diterpenoid isolated from an ancient Kuji amber2023
- Author(s)
  Kishibata Sakura、Tanaka Kurumi、Saito Tatsuo、Kimura Ken-ichi、Yajima Arata
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: - Issue: 6 Pages: 575-583
- DOI
  10.1093/bbb/zbad027
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05467, KAKENHI-PROJECT-21K05399
[Journal Article] 微生物二次代謝産物から見いだした共有結合性化合物の多様な化学生物学的特徴2020
- Author(s)
  上杉祥太、木村賢一
- Journal Title
  
  生化学
  
  Volume: 92 Pages: 556-562
- NAID
  40022342839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02885
[Journal Article] Isolation of a spirolactone norditerpenoid as a yeast Ca^2+ signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity2019
- Author(s)
  Shimizu Eisaku、Koshino Hiroyuki、Noro Aoi、Maruyama Miku、Shimoda Nozomu、Uesugi Shota、Ohnishi Motoko、Kimura Ken-ichi
- Journal Title
  
  Fitoterapia
  
  Volume: 134 Pages: 290-296
- DOI
  10.1016/j.fitote.2019.02.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-15K01810, KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-19K14046
[Journal Article] A novel Ca2+-signal transduction inhibitor, kujigamberol C, isolated from kuji amber2019
- Author(s)
  Honoka Takahashi, Hiroyuki Koshino, Miku Maruyama, Hisao Shinden, Ken-ichi Kimura
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 83 Issue: 9 Pages: 1630-1634
- DOI
  10.1080/09168451.2019.1611410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02885
[Journal Article] Kujigamberoic acid A, a carboxylic acid derivative of kujigamberol, has potent inhibitory activity against the degranulation of RBL-2H3 cells2019
- Author(s)
  Honoka Takahashi, Nozomu Shimoda, Hiroyuki Koshino, Ken-ichi Kimura
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 83 Issue: 7 Pages: 1193-1196
- DOI
  10.1080/09168451.2019.1597616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02885
[Journal Article] Studies of novel bioprobes isolated from rare natural sources using mutant yeasts2019
- Author(s)
  Ken-ichi Kimura
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 72 Issue: 8 Pages: 579-589
- DOI
  10.1038/s41429-019-0189-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02885
[Journal Article] Kujigamberol interferes with pro-inflammatory cytokine-induced expression of and N-glycan modifications to cell adhesion molecules at different stages in human umbilical vein endothelial cells2018
- Author(s)
  Fukuhara Sayuri、Tanigaki Riho、Kimura Ken-ichi、Kataoka Takao
- Journal Title
  
  International Immunopharmacology
  
  Volume: 62 Pages: 313-325
- DOI
  10.1016/j.intimp.2018.07.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04910
[Journal Article] Ca2+-Signal Transduction Inhibitors, Kujiol A and Kujigamberol B, Isolated from Kuji Amber Using a Mutant Yeast2018
- Author(s)
  Uchida Takeshi、Koshino Hiroyuki、Takahashi Shunya、Shimizu Eisaku、Takahashi Honoka、Yoshida Jun、Shinden Hisao、Tsujimura Maiko、Kofujita Hisayoshi、Uesugi Shota、Kimura Ken-ichi
- Journal Title
  
  Journal of Natural Products
  
  Volume: 81 Issue: 4 Pages: 1070-1074
- DOI
  10.1021/acs.jnatprod.7b00922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-15K07421, KAKENHI-PROJECT-16K16284
[Journal Article] Anti-allergy activities of Kuji amber extract and kujigamberol2018
- Author(s)
  Maruyama M., Kobayashi M., Uchida T., Shimizu E., Higashio H., Ohno M., Uesugi S., Kimura KI.
- Journal Title
  
  Fitoterapia
  
  Volume: 印刷中 Pages: 263-270
- DOI
  10.1016/j.fitote.2018.02.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K12730, KAKENHI-PROJECT-16H04910
[Journal Article] Allantopyrone A interferes with multiple components of the TNF receptor 1 complex and blocks RIP1 modifications in the TNF-α-induced signaling pathway2017
- Author(s)
  Quach Hue Tu、Tanigaki Riho、Yokoigawa Junpei、Yamada Yuriko、Niwa Masamitsu、Hirano Seiya、Shiono Yoshihito、Kimura Ken-ichi、Kataoka Takao
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 70 Issue: 9 Pages: 929-936
- DOI
  10.1038/ja.2017.74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04910
[Journal Article] Allantopyrone A activates the Keap1-Nrf2 pathway and protects from oxidative stress-induced cell death in PC12 cells2017
- Author(s)
  Shota Uesugi, Makoto Muroi, Yasumitsu Kondoh, Yoshihito Shiono, Hiroyuki Osada, Ken-ichi Kimura
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 70 Issue: 4 Pages: 429-434
- DOI
  10.1038/ja.2016.99
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15J04501, KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-17K07783, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-16H06276
[Journal Article] Yeast Ca2+-signal transduction inhibitors isolated from Dominican amber prevent the degranulation of RBL-2H3 cells through the inhibition of Ca2+-influx2016
- Author(s)
  Tomomi Abe, Miki Kobayashi, Yusuke Okawa, Tomoki Inui, Jun Yoshida, Hironori Higashio, Hisao Shinden, Shota Uesugi, Hiroyuki Koshino, Ken-ichi Kimura
- Journal Title
  
  Fitoterapia
  
  Volume: 113 Pages: 188-194
- DOI
  10.1016/j.fitote.2016.07.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-15J04501, KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-16K16284
[Journal Article] わさびとウド・セリ科野菜に含まれるGSK-3β阻害物質の2型糖尿病に関わる機能性2012
- Author(s)
  吉田潤、伊藤芳明、木村賢一
- Journal Title
  
  ニューフードインダストリー
  
  Volume: 54 Pages: 9-18
- NAID
  120005249353
- Data Source
  KAKENHI-PROJECT-21580108
[Journal Article] Glycogen synthase kinase-3 β inhibition of 6-(methylsulfinyl) hexyl isothiocyanate derived from wasabi (Wasabia Japonica Matsum)2011
- Author(s)
  Yoshida, J., Nomura, S. Nishizawa, N., Ito, Y. and Kimura, K.
- Journal Title
  
  Biosci. Biochem. Biotechnol
  
  Volume: 75 Pages: 136-139
- NAID
  10027897009
- Data Source
  KAKENHI-PROJECT-21580108
[Journal Article] Glycogen synthase kinase-3 β inhibition of 6(methylsulfinyl)hexyl isothiocyanate derived from wasabi(Wasabia Japonica Matsum)2011
- Author(s)
  Yoshida, J., Nomura, S.Nishizawa, N., Ito, Y., Kimura, K.
- Journal Title
  
  Biosci. Biochem. Biotechnol.
  
  Volume: 75 Pages: 136-139
- NAID
  10027897009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580108
[Journal Article] 沢わさびの抗生活習慣病特性2011
- Author(s)
  伊藤芳明、渡部達也、吉田潤、木村賢一、長澤孝志
- Journal Title
  
  ニューフードインダストリー
  
  Volume: 53 Pages: 20-24
- NAID
  120005249350
- Data Source
  KAKENHI-PROJECT-21580108
[Journal Article] 植物内生糸状菌類から創薬シード分子を探す2009
- Author(s)
  塩野義人, 木村賢一
- Journal Title
  
  化学と生物 47
  
  Pages: 390-396
- NAID
  10026435645
- Data Source
  KAKENHI-PROJECT-21580108
[Journal Article] A new benzoxepin metabolite isolated from endophytic fungus Phomopsis sp.2009
- Author(s)
  Shiono, Y., Nitto, A., Shimanuki, K., Koseki, T., Murayama, T., Miyakawa, T., Yoshida, J. and Kimura, K.
- Journal Title
  
  J. Antibiot
  
  Volume: 62 Pages: 533-535
- NAID
  10030636414
- Data Source
  KAKENHI-PROJECT-21580108
[Journal Article] A new benzoxepin metabolite isolated from endophytic fungus Phomopsis sp.2009
- Author(s)
  Y.Shiono, A.Nitto, K.Shimanuki, T.Koseki, T.Murayama, T.Miyakawa, J.Yoshida, K.Kimura
- Journal Title
  
  J.Antibiotics 62
  
  Pages: 533-535
- NAID
  10030636414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580108
[Journal Article] 植物内生糸状菌類から創薬シード分子を探す2009
- Author(s)
  塩野義人、木村賢一
- Journal Title
  
  化学と生物
  
  Volume: 47 Pages: 390-396
- NAID
  10026435645
- Data Source
  KAKENHI-PROJECT-21580108
[Patent] グルコース産生抑制剤2022
- Inventor(s)
  吉田潤、木村賢一
- Industrial Property Rights Holder
  吉田潤、木村賢一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-149634
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 食用ほおずきに含まれる新規withanolide硫酸エステルの同定と生物学的役割2024
- Author(s)
  上杉祥太、越野広雪、箱崎真友佳、菅野裕子、菅原英範、鈴木瑞季、白石朗子、結城彩花、木村賢一、矢野明
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K02000
[Presentation] 久慈産琥珀から得られるspirolactone norditerpenoidの肝細胞における糖新生抑制作用2024
- Author(s)
  吉田潤、工藤唯、伊藤芳明、木村賢一
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-21K02134
[Presentation] 酵母ユビキチンリガーゼRSP5変異株を用いた久慈産琥珀由来の生物活性物質の探索2024
- Author(s)
  丹場晴也，越野広雪，野川俊彦，今井央由，高木博史，木村賢一
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] スペイン産琥珀と久慈産琥珀の生物活性物質の構造と活性の比較研究2024
- Author(s)
  笹本啓将，鈴木瑞季，越野広雪，CESAR Menor-Salvan，木村賢一
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 珪化木の遺伝子破壊酵母に対する生物活性と活性物質の同定2024
- Author(s)
  田端菜々海，木村賢一
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 遺伝子変異酵母株を用いた久慈産琥珀からの生物活性物質の単離精製と構造2023
- Author(s)
  池田はるな，越野広雪，鈴木瑞季，木村賢一
- Organizer
  日本農芸化学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 山菜由来の3,6-Epidioxy-1,10-bisaboladiene（EDBD）はフェロトーシス様細胞死を誘導する2023
- Author(s)
  Uskhbayar Narandulam、髙野侑恵、上杉祥太、室井誠、長田裕之、木村賢一
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K02000
[Presentation] RBL-2H3細胞の脱顆粒抑制活性を指標とした久慈産琥珀由来の生物活性物質の探索2023
- Author(s)
  田中来実，越野広雪，木村賢一
- Organizer
  第65回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 久慈産琥珀の化学生物学と地球化学の融合研究2023
- Author(s)
  木村賢一
- Organizer
  日本ケミカルバイオロジー学会・産学連携委員会
- Invited
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] アレルギー症状原因因子ロイコトリエンの産生を抑制する農林水産物の探索2023
- Author(s)
  箱崎真友佳、菅野裕子、結城彩花、矢野明、木村賢一、上杉祥太
- Organizer
  日本農芸化学会東北支部第158回大会
- Data Source
  KAKENHI-PROJECT-23K02000
[Presentation] 植物の化石抽出物が示すRBL-2H細胞に対する抗アレルギー活性2023
- Author(s)
  松本千里，笹本啓将，田端菜々海，Lethi Ngocanh，田中来実，木村賢一
- Organizer
  日本生化学会東北支部例会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 岩手大学大学院連合農学研究科と放射光施設ナノテラスを介したネットワークについて－植物と琥珀への利用例2023
- Author(s)
  木村賢一
- Organizer
  日本農芸化学会東北支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 遺伝子破壊酵母株を用いたウクライナ産琥珀に含まれる生物活性物質の単離精製と同定（学生優秀発表賞受賞）2023
- Author(s)
  菊池優花, 目黒紀至,　田端菜々海, 笹本啓将,　木村賢一
- Organizer
  日本農芸化学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 遺伝子変異酵母株の生育回復活性を用いた中国産琥珀に含まれる生物活性物質の単離精製と同定2022
- Author(s)
  Lethi NgocAnh，松本千里，高木博史，野川俊彦，越野広雪，木村賢一
- Organizer
  2023年日本農芸化学会（広島・Web開催）
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] マダガスカル産コーパル由来の生物活性物質の単離精製、構造解析ならびに生物活性2022
- Author(s)
  田端菜々海, 松本千里, 田中来実, 笹本啓将, 丹場晴也, 古山達貴, 越野広雪, 木村賢一
- Organizer
  日本農芸化学会北海道支部・東北支部合同大会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 酵母ユビキチンリガーゼRSP5変異株を高温ストレス下で生育を回復させる久慈産琥珀由来の生物活性物質の探索2022
- Author(s)
  丹場晴也，田中来実，高木博史，越野広雪，木村賢一
- Organizer
  2022年日本農芸化学会, 3F02-03.
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 酵母のユビキチンリガーゼRsp5変異酵母株を用いた久慈産琥珀由来の生物活性物質の探索2022
- Author(s)
  丹場晴也，田中来実，高木博史，越野広雪，木村賢一
- Organizer
  天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] Allantopyrone Aはヒト繊維肉腫HT-1080細胞においてプロテアソーム活性を阻害することによってHF-1αタンパク質を安定化する2022
- Author(s)
  奥田千遥、上田悠斗、武田賢治、塩野義人、木村賢一、片岡孝夫
- Organizer
  日本農芸化学会2022年度（令和4年度）大会
- Data Source
  KAKENHI-PROJECT-19H02885
[Presentation] Kujigamberolとその構造類縁体はIFN-γとIL-2の発現を阻害する2022
- Author(s)
  山口梨夏子、谷垣里穂、YARANGSEE Waraluk、東幸奈、木村賢一、片岡孝夫
- Organizer
  日本農芸化学会2022年度（令和4年度）大会
- Data Source
  KAKENHI-PROJECT-19H02885
[Presentation] Kujigamberol B の合成と構造活性相関（学生優秀発表賞受賞）2022
- Author(s)
  岸端咲良, 田中来実，斉藤竜男，木村賢一, 矢島新
- Organizer
  日本農薬学会第 48 回大会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 久慈琥珀から単離された kujigamberol B の合成と構造活性相関2022
- Author(s)
  岸端咲良, 斉藤竜男，田中来実, 木村賢一, 矢島新
- Organizer
  第66回香料・テルペンおよび精油化学に関する討論会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 岩手県久慈市で産出される琥珀とジェットの生物活性と活性物質の比較分析2022
- Author(s)
  笹本啓将，松本千里，越野広雪，木村賢一
- Organizer
  2023年日本農芸化学会（広島・Web開催）
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] Elucidation of biologically active compounds from an insoluble fraction of Kuji amber.2021
- Author(s)
  J. Abe, H. Koshino, K. Oikawa, Y. Miura, S. Uesugi, M. Shirai, K. Kimura
- Organizer
  Pacifichem 2021, Dec. 17-21, 3440311.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] Analysis of functional mechanism and target molecules of ricinoleic acid derived from castor oil2021
- Author(s)
  Jun Yoshida, Yusuke Okawa, Takuya Oyama, Nozomu Shimoda, Shota Uesugi, Hiroshi Takagi, Yoshiaki Ito, Ken-ichi Kimura
- Organizer
  2021 International Chemical Congress of Pacific Basin Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K02134
[Presentation] ドイツ産琥珀と久慈産琥珀の生物活性物質の構造と活性の比較研究2021
- Author(s)
  鈴木瑞季、井上奈々、Menor-Salvan CESAR、越野広雪、木村賢一
- Organizer
  日本農芸化学会2021年度（令和3年度）大会
- Data Source
  KAKENHI-PROJECT-19H02885
[Presentation] 久慈産琥珀抽出物の不思議な生物活性の謎に迫る2021
- Author(s)
  田中来実, 及川和吉, 越野広雪，白井誠之，木村賢一
- Organizer
  日本生化学会東北支部　第87回例会・シンポジウム，5月29日（土）, p83
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 久慈産琥珀超臨界メタノール分解・抽出物からの抗アレルギー活性物質の探索2021
- Author(s)
  田中来実，阿部純平，及川和吉，越野広雪，白井誠之，木村賢一
- Organizer
  日本農芸化学会東北支部第156回大会，10月9日（土），A13，p17.
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] Bioactive properties of non-methylene-interrupted dienoic fatty acids in eukaryotic cells2021
- Author(s)
  Jun Yoshida, Shota Uesugi, Tetsuaki Kawamura, Ken-ichi Kimura, Dawei Hu, Shuang Xia, Naoki Toyooka, Masao Ohnishi, Hideki Kawashima
- Organizer
  2021 International Chemical Congress of Pacific Basin Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K02134
[Presentation] The relationship between PPM1A activation activity and the inhibition activity of degranulation in RBL-2H3 cells.2021
- Author(s)
  Y. Miura, Y. Kudo, H. Koshino, T. Kataoka, M. Ohnishi, K. Kimura
- Organizer
  Pacifichem 2021, Dec. 17-21, 3440337.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] The relationship between PPM1A activation activity and the inhibition activity of degranulation in RBL-2H3 cells2021
- Author(s)
  Yuka Miura, Yui Kudo, Hiroyuki Koshino, Takao Kataoka, Motoko Ohnishi, Ken-ichi Kimura
- Organizer
  Pacifichem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02885
[Presentation] New inhibitors of melanin production in B16 mouse melanoma cells from the methanol extract of Kuji amber.2021
- Author(s)
  J. Abe, S. Suzuki, S. Takahashi, H. Koshino, K. Kimura
- Organizer
  Pacifichem 2021, Dec. 17-21, 3440283.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] ケミカルバイオロジーによる震災復興と地方創生への挑戦!!2021
- Author(s)
  木村賢一
- Organizer
  日本農芸化学会東北支部第155回大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H02885
[Presentation] 琥珀と微生物由来の生物活性物質のPPM1A活性化作用とRBL-2H3細胞での脱顆粒抑制活性との関連性2020
- Author(s)
  三浦悠花、松尾洋孝、中島琢自、片岡孝夫、大西素子、木村賢一
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H02885
[Presentation] 久慈産琥珀に含まれるPPM1A活性化物質の構造とその機能2019
- Author(s)
  三浦悠花、野呂葵、越野広雪、片岡孝夫、大西素子、木村賢一
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H02885
[Presentation] 酵母を用いて久慈産琥珀から単離された高極性の新規抗アレルギー物質2018
- Author(s)
  阿部純平、越野広雪、下田希、高橋穂乃香、新田久男、木村賢一
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-16H04910
[Presentation] 久慈産と他の日本産琥珀の生物活性物質、生物活性、並びにバイオマーカーの比較2018
- Author(s)
  下田希、川村哲晃、清水栄作、植田直見、木村賢一
- Organizer
  日本農芸化学会2018年度北海道支部・東北支部合同大会
- Data Source
  KAKENHI-PROJECT-16H04910
[Presentation] Kujigamberolおよびその類縁体は炎症性サイトカイン誘導性の細胞接着因子の発現と糖鎖修飾に作用する2018
- Author(s)
  谷垣里穂、福原早友里、木村賢一、片岡孝夫
- Organizer
  2018年度日本農芸化学会関西支部大会第505回講演会
- Data Source
  KAKENHI-PROJECT-16H04910
[Presentation] 久慈産琥珀に含まれる生物活性物質の精製法の改良と新規物質の探索2017
- Author(s)
  高橋穂乃香、越野広雪、川村哲晃、清水栄作、新田久男、上杉祥太、大野美紗、木村賢一
- Organizer
  日本農芸化学会2017年度(平成29年度)大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Data Source
  KAKENHI-PROJECT-16H04910
[Presentation] 炎症性サイトカインによって誘導される細胞接着因子に対するkujigamberolの作用機序の解明2017
- Author(s)
  福原早友里、木村賢一、片岡孝夫
- Organizer
  日本農芸化学会2017年度(平成29年度)大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Data Source
  KAKENHI-PROJECT-16H04910
[Presentation] Allantopyrone A binds or crosslinks TNF receptor 1 and inhibits TNF-α-induced signaling pathway2017
- Author(s)
  Hue Tu Quach, Junpei Yokoigawa, Yoshihito Shiono, Ken-ichi Kimura, Takao Kataoka
- Organizer
  日本農芸化学会2017年度(平成29年度)大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Data Source
  KAKENHI-PROJECT-16H04910
[Presentation] サワラの球果由来PisiferdiolとCa^<2+>シグナル伝達に関わる遺伝子変異酵母株に対する生育円活性2011
- Author(s)
  油井信弘、宮川都吉、大西素子、木村賢一
- Organizer
  第55回香料・テルペンおよび精油化学に関する討論会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-21580108
[Presentation] Chemical investigation on biological active compounds from endophytic fungi2010
- Author(s)
  Y.Shiono, K.Kimura
- Organizer
  日本農芸化学会2010年度(平成22年度)大会
- Place of Presentation
  東京大学(東京)
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21580108
[Presentation] 山菜のウドとセリ科野菜に含まれるGSK-3β阻害物質falcarindiolの糖尿病に対する効果2010
- Author(s)
  吉田潤、諏訪紗央里、伊藤芳明、宮川都吉、木村賢一
- Organizer
  第15回日本フードファクター学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21580108
[Presentation] PP2C活性化物質PisiferdiolのCa^<2+>シグナル伝達に関わる遺伝子変異酵母に対する作用メカニズムの解析2010
- Author(s)
  油井信弘、宮川都吉、大西素子、木村賢一
- Organizer
  第5回日本ケミカルバイオロジー学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21580108
[Presentation] Chemical investigation on biological active compounds from endophytic fungi2010
- Author(s)
  Shiono, Y. and Kimura, K.
- Organizer
  2010年度日本農芸化学会シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21580108
[Presentation] PP2C活性化物質PisiferdiolのCa^<2+>シグナル伝達に関わる遺伝子変異酵母に対する作用メカニズムの解析2010
- Author(s)
  油井信弘、宮川都吉、大西素子、木村賢一
- Organizer
  第5回日本ケミカルバイオロジー学会
- Place of Presentation
  慶応大学(神奈川)
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-21580108
[Presentation] 山菜のウドとセリ科野菜に含まれるGSK-3β阻害物質falcarindiolの糖尿病に対する効果2010
- Author(s)
  吉田潤、諏訪紗央里、伊藤芳明、宮川都吉、木村賢一
- Organizer
  第15回日本フードファクター学会
- Place of Presentation
  仙台市民会館(宮城)
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-21580108
[Presentation] 遺伝子変異酵母を用いた新たなバイオプローブの探索とその分子標的研究2009
- Author(s)
  木村賢一
- Organizer
  いわて海洋バイオテクノロジ-研究会研究交流技術セミナー
- Place of Presentation
  釜石
- Year and Date
  2009-08-06
- Data Source
  KAKENHI-PROJECT-21580108
[Presentation] 遺伝子変異酵母を用いた新たなバイオプローブの探索とその分子標的研究2009
- Author(s)
  木村賢一
- Organizer
  いわて海洋バイオテクノロジー研究会
- Place of Presentation
  釜石マリンバイオテクノロジー研究所(岩手県)
- Year and Date
  2009-08-06
- Data Source
  KAKENHI-PROJECT-21580108
[Presentation] Ca^<2+>シグナル伝達に関わる遺伝子変異酵母の阻害剤に対する表現型と標的分子との関連性2009
- Author(s)
  吉田潤、宮川都吉、木村賢一
- Organizer
  日本ケミカルバイオロジー学会第4回年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21580108
[Presentation] サワラの球果由来PisiferdiolとCa^<2+>シグナル伝達に関わる遺伝子変異酵母株に対する生育円活性
- Author(s)
  油井信弘、宮川都吉、大西素子、木村賢一
- Organizer
  第55回香料・テルペンおよび精油化学に関する討論会
- Place of Presentation
  筑波大学
- Data Source
  KAKENHI-PROJECT-21580108

1. KATAOKA Takao (20242307)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. 吉田潤 (20611007)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 伊藤芳明 (50312517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 越野広雪 (50321758)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
5. SHIONO Yoshihito (80361278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. 上杉祥太 (30795901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 室井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 斉藤竜男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 東尾浩典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIMURA Ken-ichi 木村 賢一

Research Projects

Research Products

Co-Researchers

Integrated study on amber's unique chemical space and diverse biological activitiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Design of functionality and safety by molecular bleeding in Petasites japonicus

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

食材ポリアセチレン化合物による肝細胞エネルギー代謝制御機構の統合的解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated analysis of chemical reaction products in Cretaceous amber and their biological activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of bioprobes targeting inflammatory reaction and hypoxic respose

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanisms of bioprobes on signaling pathways of inflammatory responses and hypoxic responses

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on molecular targets of new biological compounds having activity against the mutant yeast involving calcium signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] BIOACTIVE COMPOUNDS from NATURAL SOURCES (Second Edition) Edited by Corrado Tringali, Chapter 16. Endophytic microorganisms as a source of bioactive compounds2012

Author(s)

Publisher

Data Source

[Book] 16 Endophytic microorganisms as a source of bioactive compounds, Bioactive Compounds from Natural sources (2nd Edition), Edited by Corrado Tringali, Edited by Corrado Tringali2012

Author(s)

Publisher

Data Source

[Journal Article] 3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Golden berry leaf extract containing withanolides suppresses TNF-α and IL-17 induced IL-6 expression in HeLa Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 3,6-Epidioxy-1,10-bisaboladiene and sulfasalazine synergistically induce ferroptosis-like cell death in human breast cancer cell lines2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and structure?activity relationship of kujigamberol B, a dinorlabdane diterpenoid isolated from an ancient Kuji amber2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 微生物二次代謝産物から見いだした共有結合性化合物の多様な化学生物学的特徴2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Isolation of a spirolactone norditerpenoid as a yeast Ca^2+ signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity2019

KIMURA Ken-ichi 木村賢一