Fujita Nobuyuki 藤田順之

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藤田順之フジタノブユキ

FUJITA Nobuyuki 藤田順之

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Researcher Number	30348685
Affiliation (Current)	2025: 藤田医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023: 藤田医科大学, 医学部, 教授 2019 – 2021: 藤田医科大学, 医学部, 教授 2017: 慶應義塾大学, 医学部, 助教 2016 – 2017: 慶應義塾大学, 医学部(信濃町), 講師 2013 – 2015: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Keywords	Principal Investigator 髄核 / 椎間板変性 / 椎間板 / 黄色靭帯 / 腰部脊柱管狭窄症 / 酸化ストレス / 黄色靭帯肥厚 / 脊椎 / 炎症 / 変性 … More / 慢性炎症 / ヒアルロン酸 / 脊索腫 / FSTL1 / JAK/STAT / 小胞体ストレス / 細胞株 / 繊維輪 / PHD / Sox9 / Syndecan4 / HIF-1alpha / 腰椎変性疾患 Less

Molecular mechanisms of ligamentum flavum hypertrophy in lumbar spinal canal stenosis patientsPrincipal Investigator
- Principal Investigator
  
  藤田順之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Fujita Health University
Development of novel treatment for intervertebral disc degenerationPrincipal Investigator
- Principal Investigator
  
  Fujita Nobuyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Fujita Health University
Tissue homeostasis of intervertebral discPrincipal Investigator
- Principal Investigator
  
  Fujita Nobuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Analysis of molecular mechanisms maintaining homeostasis of intervertebal disc and leading to degenerationPrincipal Investigator
- Principal Investigator
  
  FUJITA Nobuyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020 2019 2017 2016 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] Potential Involvement of Oxidative Stress in Ligamentum Flavum Hypertrophy2023
- Author(s)
  Ito K, Kise H, Suzuki S, Nagai S, Hachiya K, Takeda H, Kawabata S, Ikeda D, Takubo K, Kaneko S, Fujita N.
- Journal Title
  
  J Clin Med
  
  Volume: 12 Issue: 3 Pages: 808-808
- DOI
  10.3390/jcm12030808
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-23K08661, KAKENHI-PROJECT-20K18041
[Journal Article] Impact of oxidized LDL/LOX-1 system on ligamentum flavum hypertrophy2022
- Author(s)
  Nagai S, Hachiya K, Takeda H, Ikeda D, Kawabata S, Watanabe K, Kaneko S, Fujita N.
- Journal Title
  
  J Orthop Sci .
  
  Volume: - Issue: 3 Pages: 669-676
- DOI
  10.1016/j.jos.2022.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09634
[Journal Article] Efficacy of hyaluronic acid on intervertebral disc inflammation: An in vitro study using notochordal cell lines and human disc cells2021
- Author(s)
  Yamamoto T, Suzuki S, Fujii T, Mima Y, Watanabe K, Matsumoto M, Nakamura M, Fujita N
- Journal Title
  
  J Orthop Res
  
  Volume: - Issue: 10 Pages: 2197-2208
- DOI
  10.1002/jor.24933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09634
[Journal Article] The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration.2017
- Author(s)
  T. Fujii, N. Fujita, S. Suzuki, K. Watanabe, T. Tsuji, K. Ishii, T. Takaki, K. Umezawa, T. Miyamoto, K. Horiuchi, M. Matsumoto, M. Nakamura
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: - Issue: 5 Pages: 1334-1345
- DOI
  10.1002/jor.23787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-15K10420
[Journal Article] Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration.2017
- Author(s)
  Suzuki S, Fujita N, Fujii T, Watanabe K, Yagi M, Tsuji T, Ishii K, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M.
- Journal Title
  
  Spine (Phila Pa 1976)
  
  Volume: 42 Issue: 14 Pages: E817-E824
- DOI
  10.1097/brs.0000000000001982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10420
[Journal Article] Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration2016
- Author(s)
  Suzuki S, Fujita N, Fujii T, Watanabe K, Yagi M, Tsuji T, Ishii K, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M
- Journal Title
  
  Spine
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10420
[Journal Article] Chordoma-derived cell line U-CH1-N recapitulates the biological properties of notochordal nucleus pulposus cells2016
- Author(s)
  Fujita N, Suzuki S, Watanabe K, Ishii K, Watanabe R, Shimoda M, Takubo K, Tsuji T, Toyama Y, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M
- Journal Title
  
  J Orthop Res
  
  Volume: ３４ Issue: 8 Pages: 1341-50
- DOI
  10.1002/jor.23320
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10420
[Journal Article] HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells2014
- Author(s)
  Fujita N, Hirose Y, Tran CM, Chiba K, Miyamoto T, Toyama Y, Shapiro IM, Risbud MV.
- Journal Title
  
  FASEB J.
  
  Volume: 28 Issue: 6 Pages: 2455-2465
- DOI
  10.1096/fj.13-243741
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25861337
[Journal Article] Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity.2013
- Author(s)
  Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 18 Pages: 12654-12666
- DOI
  10.1074/jbc.m112.448860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861337
[Journal Article] Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB2013
- Author(s)
  Tian Y, Yuan W, Fujita N, Wang J, Wang H, Shapiro IM, Risbud MV
- Journal Title
  
  Am J Pathol
  
  Volume: 182 Issue: 6 Pages: 2310-2321
- DOI
  10.1016/j.ajpath.2013.02.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861337
[Patent] 椎間板変性症に対する治療薬ＪＡＫ‐ＳＴＡＴ３阻害剤2017
- Inventor(s)
  藤田順之、鈴木悟士、松本守雄、中村雅也
- Industrial Property Rights Holder
  藤田順之、鈴木悟士、松本守雄、中村雅也
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K10420
[Patent] 小胞体ストレスを標的とする椎間板変性症対する治療薬2017
- Inventor(s)
  藤田順之、藤井武、松本守雄、中村雅也
- Industrial Property Rights Holder
  藤田順之、藤井武、松本守雄、中村雅也
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K10420
[Presentation] 黄色靭帯肥厚における酸化ストレスの関与2024
- Author(s)
  伊藤　慶、永井聡太、蜂谷　紅、武田太樹、川端　走野、池田大樹、金子慎二郎、藤田順之
- Organizer
  第53回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-23K08661
[Presentation] 黄色靭帯肥厚における酸化ストレスの関与2023
- Author(s)
  伊藤　慶、永井聡太、蜂谷　紅、武田太樹、川端　走野、池田大樹、金子慎二郎、藤田順之
- Organizer
  第38回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K08661
[Presentation] 黄色靭帯肥厚と酸化LDL/LOX-1シグナルの関係2021
- Author(s)
  永井聡太、武田太樹、池田大樹、金子慎二郎、藤田順之
- Organizer
  日本整形外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09634
[Presentation] 腰部脊柱管狭窄症の基礎と臨床2020
- Author(s)
  藤田　順之
- Organizer
  第93回日本整形外科学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09634
[Presentation] Hyaluronic acid metabolism in intervertebral disc degeneration2020
- Author(s)
  Tatsuya Yamamoto, Satoshi Suzuki, Takeshi Fujii, Yuichiro Mima, Kota Watanabe, Morio Matsumoto, Masaya Nakamura, Nobuyuki Fujita
- Organizer
  ORS Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09634
[Presentation] 椎間板変性におけるヒアルロン酸代謝2019
- Author(s)
  山本竜也、　鈴木悟士、藤井　武、美馬　雄一郎、渡辺航太、松本守雄、中村雅也、藤田順之
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19K09634
[Presentation] 椎間板変性に対する抗酸化剤の効果.2017
- Author(s)
  藤田順之
- Organizer
  第20回日本低侵襲脊椎外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K10420
[Presentation] Molecular mechanisms of intervertebral disc degeneration.2017
- Author(s)
  Fujita N.
- Organizer
  5th International Spine symposium of Four Universities
- Invited
- Data Source
  KAKENHI-PROJECT-15K10420
[Presentation] 椎間板変性に酸化ストレスが関与している2017
- Author(s)
  藤田順之
- Organizer
  第35回日本骨代謝学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K10420
[Presentation] Potential Involvement of unfolded protein response in the pathogenesis of intervertbral disc degeneration.2017
- Author(s)
  Fujita N, Fujii T.
- Organizer
  ORS PSRS 4th International Spine Research Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10420
[Presentation] 腰痛に対する抗酸化治療2017
- Author(s)
  藤田順之
- Organizer
  第25回日本腰痛学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K10420
[Presentation] Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration.2017
- Author(s)
  Fujita N, Suzuki S, Fujii T, Watanabe K, Ishii K, Tsuji T, Miyamoto T, Horiuchi K, Matsumoto M, Nakamura M.
- Organizer
  30th annual meeting of Japanese Society of Cartilage Metabolism
- Invited
- Data Source
  KAKENHI-PROJECT-15K10420
[Presentation] HIF-1-PHD2 Axis Controls Expression of Syndecan-4 in Hypoxic Nucleus Pulposus Cells of the Intervertebral Disc: Evidence of Context Dependent Function in Health and Disease2014
- Author(s)
  Nobuyuki Fujita, Yuichiro Hirose, Cassie M. Tran, Kazuhiro Chiba, Takeshi Miyamoto,Yoshiaki Toyama, Irving M. Shapiro, Makarand V. Risbud
- Organizer
  2014 ORS Annual Meeting
- Place of Presentation
  New Orleans, Louisiana
- Data Source
  KAKENHI-PROJECT-25861337
[Presentation] 椎間板髄核細胞におけるsyndecan4の発現制御メカニズムおよび機能解析2013
- Author(s)
  藤田順之,　千葉一裕,　宮本健史,　松本守雄,　戸山芳昭, Irving Shapiro, Makarand Risbud
- Organizer
  日本整形外科学会基礎学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25861337
[Presentation] Brachyury is an essential transcription factor for maintaining homeostasis in notochordal cells
- Author(s)
  N. Fujita, R. Watanabe, S. Suzuki, T. Hikata, K. Watanabe, K. Ishii, T. Miyamoto, Y. Toyama, M. Matsumoto
- Organizer
  61th Annual Meeting Orthopaedic Research Society
- Place of Presentation
  米国ラスベガス
- Year and Date
  2015-03-28 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-25861337
[Presentation] Molecular characterization of chordoma cell line U-CH1-N: Applications for intervertebral disc research
- Author(s)
  N. Fujita, N. Hosogane, K. Ishii, T. Hikata, Y. Toyama, T. Miyamoto. M. Matsumoto
- Organizer
  41th International Society for the Study of the Lumber Spine
- Place of Presentation
  韓国ソウル
- Year and Date
  2014-06-03 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-25861337
[Presentation] Follistatin-like protein 1 regulates the expression of type II collagen via BMP pathway in　notochordal cells
- Author(s)
  R. Watanabe, N. Fujita, S. Suzuki, T. Hikata, K. Watanabe, K. Ishii, T. Miyamoto, Y. Toyama, M. Matsumoto
- Organizer
  61th Annual Meeting Orthopaedic Research Society
- Place of Presentation
  米国ラスベガス
- Year and Date
  2015-03-28 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-25861337
[Presentation] Reactive oxygen species are therapeutic targets for intervertebral disc degeneration
- Author(s)
  S. Suzuki, N. Fujita, N. Hosogane, K. Ishii, R. Watanabe, T. Hikata K. Takubo, K. Watanabe, K. Horiuchi, Y. Toyama, T. Miyamoto, M. Matsumoto
- Organizer
  61th Annual Meeting Orthopaedic Research Society
- Place of Presentation
  米国ラスベガス
- Year and Date
  2015-03-28 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-25861337

1. 松本守雄 (40209656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 堀内圭輔 (30327564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 梅沢一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujita Nobuyuki 藤田 順之

藤田 順之 フジタ ノブユキ

FUJITA Nobuyuki 藤田 順之

Research Projects

Research Products

Co-Researchers

Molecular mechanisms of ligamentum flavum hypertrophy in lumbar spinal canal stenosis patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel treatment for intervertebral disc degenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tissue homeostasis of intervertebral discPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of molecular mechanisms maintaining homeostasis of intervertebal disc and leading to degenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Potential Involvement of Oxidative Stress in Ligamentum Flavum Hypertrophy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of oxidized LDL/LOX-1 system on ligamentum flavum hypertrophy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of hyaluronic acid on intervertebral disc inflammation: An in vitro study using notochordal cell lines and human disc cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration2016

Author(s)

Journal Title

Data Source

[Journal Article] Chordoma-derived cell line U-CH1-N recapitulates the biological properties of notochordal nucleus pulposus cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB2013

Author(s)

Journal Title

DOI

Data Source

[Patent] 椎間板変性症に対する治療薬ＪＡＫ‐ＳＴＡＴ３阻害剤2017

Fujita Nobuyuki 藤田順之

藤田順之フジタノブユキ

FUJITA Nobuyuki 藤田順之