KOYAMA NOBUYUKI 小山信之

… Alternative Names

NOBUYUKI KOYAMA 小山信之

KOYAMA Nobuyuki 小山信之

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Researcher Number	30353460
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 兼任教授 2025: 埼玉医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023: 埼玉医科大学, 医学部, 教授 2021 – 2022: 東京医科大学, 医学部, 兼任教授 2017 – 2020: 東京医科大学, 医学部, 教授 2016: 自治医科大学, 医学部, 非常勤講師 2015: 自治医科大学, 医学部, 研究員 … More 2014: 自治医科大学, 医学部, 准教授 2009 – 2011: Saitama Medical University, 医学部, 講師 2006: Saitama Medical University, Faculty of Medicine, Assistant Professor, 医学部, 講師 2004 – 2005: 東京医科歯科大学, 医学部附属病院, 助手 2003: 癌研究会, 研究員 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 非小細胞肺癌 / siRNA / 間質性肺炎 / 転移 / 間質性肺炎合併肺癌 / RNA-seq / microarray / NCI-H1299 / flow cytometry / β-catenin … More / SEMA3B / IGFBP-6 / 網羅的発現解析 / マイクロRNA / 肺癌 / 浸潤 / EZH2 / CRISPR/Cas9 / 転写制御ネットワーク / 統合解析 / ATAC-seq / 共通発症・進展経路 / 非コードRNAネットワーク / バイオマーカー / エクソソーム / lncRNA / Exosome / LncRNA / モデルマウス / 共通発症機序 / 間質性肺炎合併非小細胞肺癌 / 疾患モデルマウス / 肺線維化 / 筋線維芽細胞分化 / 上皮間葉転換 / inhibition of cell proliferation / 質量分析 / RNAi / マイクロアレイ解析 / RFMA3B / RASSF1A / Microarray analysis / Cell growth assay / Colony formation assay / FACS Calibur / Apoptosis / 細胞増殖抑制 / マイクロRNA発現 / EZH2発現 / 癌性胸膜炎 / 網羅解析 / EMT / 小細胞肺癌 / miR-4448 / 予後診断マーカー / CHIP-on-chip / Effector / ChIP-on-chip / H3K27 / 個別化医療 / ゲノムワイド / 予後予測因子 Less

Elucidation of transcriptional regulatory mechanism defining the onset and progression of lung cancer with comorbid interstitial pneumonia and its application for its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  小山信之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Saitama Medical University
Elucidation of the lncRNA-mediated mechanism underlying the onset and progression of lung cancer associated with interstitial pneumonia and development of biomarkersPrincipal Investigator
- Principal Investigator
  
  Koyama Nobuyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tokyo Medical University
Identification of microRNA underying the common pathogenic mechanism of lung cancer and interstitial pneumonia and establishment of a basis for its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  Nobuyuki Koyama
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tokyo Medical University
Identification of a factor determining invasion and metastasis in non-small cell lung cancer and its therapeutic application based on comprehensive microRNA analysisPrincipal Investigator
- Principal Investigator
  
  NOBUYUKI KOYAMA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jichi Medical University
Exploration of a prognostic biomarker for lung cancer as personalized medicine using a genome-wide approachPrincipal Investigator
- Principal Investigator
  
  KOYAMA Nobuyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Saitama Medical University
Indentification of a novel lung cancer-associated factor and elucidation of the mechanism for cancer pathology using genome and proteome analysesPrincipal Investigator
- Principal Investigator
  
  KOYAMA Nobuyuki, 臼井裕
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Saitama Medical University
  Tokyo Medical and Dental University
ゲノム・プロテオーム解析による新規肺癌関連因子の同定と癌病態機構の解明Principal Investigator
- Principal Investigator
  
  小山信之
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Japanese Foundation For Cancer Research

All 2020 2019 2018 2017 2016 2015 2014 2012 2011 2010 2009 2007 2006 Other

All Journal Article Presentation Book

[Book] Drug-Induced Lung Injury2017
- Author(s)
  Koyama N.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26461195
[Book] 気管支喘息の診断と治療〜COPD合併例を含めて〜2016
- Author(s)
  小山信之
- Total Pages
  6
- Publisher
  北足立郡市医師会
- Data Source
  KAKENHI-PROJECT-26461195
[Book] 肺癌薬物療法の進歩と支持療法2016
- Author(s)
  長井良昭、小山信之
- Total Pages
  5
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-26461195
[Book] Chapter 14 Common pathways in IPF and lung cancer. Idiopathic Pulmonary Fibrosis - Advances in Diagnostic Tools and Disease Management2015
- Author(s)
  Koyama N.
- Total Pages
  11
- Publisher
  Spiringer
- Data Source
  KAKENHI-PROJECT-26461195
[Journal Article] Serum C-reactive protein level predicts clinical outcomes in patients with non-small cell lung cancer harboring EGFR mutations.2020
- Author(s)
  Koyama N, Aoshiba K, Nakamura H.
- Journal Title
  
  Cancer Invest.
  
  Volume: 38 Issue: 2 Pages: 122-129
- DOI
  10.1080/07357907.2020.1721522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09671
[Journal Article] Simultaneous metastasized primary unknown signet ring cell carcinoma of the cervical lymph node and mucoepidermoid carcinoma of the parotid gland as double cancers.2020
- Author(s)
  Miyake K, Kondo T, Koyama N, Hirano H, Wakiya M, Takeda A, Iwasawa T, Kikawada N, Hanyu K, Ogawa Y, Tsukahara K.
- Journal Title
  
  Auris Nasus Larynx.
  
  Volume: 47 Issue: 1 Pages: 163-167
- DOI
  10.1016/j.anl.2019.03.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09671
[Journal Article] Pulmonary mucoepidermoid carcinoma arising in a patient with Kartagener syndrome.2020
- Author(s)
  Nagai Y, Koyama N, Iwai Y, Tsubochi H, Hiruta M, Mizushina Y, Koyama S, Ishikawa Y, Hagiwara K
- Journal Title
  
  BMC Pulm Med.
  
  Volume: 20(1) Issue: 1 Pages: 93-93
- DOI
  10.1186/s12890-020-1133-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-17K09671, KAKENHI-PROJECT-19H03446
[Journal Article] A case of miliary tuberculosis presenting as massive hepatosplenomegaly and fatal hepatic failure.2020
- Author(s)
  Kawagoe J, Iwai Y, Kawamata G, Koyama N, Nakamura H, Aoshiba K.
- Journal Title
  
  ID Cases.
  
  Volume: 19 Pages: e00707-e00707
- DOI
  10.1016/j.idcr.2020.e00707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09671
[Journal Article] 非小細胞肺癌薬物療法の最新情報と今後の課題2019
- Author(s)
  小山信之
- Journal Title
  
  都薬雑誌
  
  Volume: 41 Pages: 4-12
- Data Source
  KAKENHI-PROJECT-17K09671
[Journal Article] Efficacy and safety of nivolumab in 100 patients with recurrent or metastatic head and neck cancer a retrospective multicenter study.2019
- Author(s)
  Okamoto I, Sato H, Kondo T, Koyama N, Fushimi C, Okada T, Miura K, Matsuki T, Yamashita T, Omura G, and Tsukahara K.
- Journal Title
  
  Acta otolaryngol
  
  Volume: 139 Issue: 10 Pages: 918-925
- DOI
  10.1080/00016489.2019.1648867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09339, KAKENHI-PROJECT-17K09671
[Journal Article] Idiopathic pulmonary fibrosis in small cell lung cancer as a predictive factor for poor clinical outcome and risk of its exacerbation.2019
- Author(s)
  Koyama N, Iwai Y, Nagai Y, Aoshiba K, Nakamura H.
- Journal Title
  
  PLOS ONE.
  
  Volume: 14 Issue: 8 Pages: e0221718-e0221718
- DOI
  10.1371/journal.pone.0221718
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09671
[Journal Article] Hypercapnic tumor microenvironment confers chemoresistance to lung cancer cells by reprograming mitochondrial metabolism in vitro.2019
- Author(s)
  Kikuchi R, Iwai Y, Tsuji T, Watanabe Y, Koyama N, Yamaguchi K, Nakamura H, Aoshiba K.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 134 Pages: 200-214
- DOI
  10.1016/j.freeradbiomed.2019.01.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09671
[Journal Article] Effectiveness of nanoparticle albumin-bound paclitaxel plus carboplatin in non-small cell lung cancer patients with malignant pleural effusion.2018
- Author(s)
  Koyama N, Watanabe Y, Iwai Y, Nagai Y, Aoshiba K, Nakamura H.
- Journal Title
  
  Neoplasma.
  
  Volume: 65 Issue: 01 Pages: 132-139
- DOI
  10.4149/neo_2018_170206n78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09671
[Journal Article] Prognostic Factors and Efficacy of First-Line Chemotherapy in Patients with Advanced Thymic Carcinoma2018
- Author(s)
  Ko R, Shukuya T, Okuma Y, Tateishi K, Imai H, Iwasawa S, Miyauchi E, Fujiwara A, Sugiyama T, Azuma K, Muraki K, Yamasaki M, Tanaka H, Takashima Y, Soda S, Ishimoto O, Koyama N, Morita S, Kobayashi K, Nukiwa T, Takahashi K; North East Japan Study Group.
- Journal Title
  
  Oncologist
  
  Volume: unknown Issue: 10 Pages: 1210-1217
- DOI
  10.1634/theoncologist.2017-0586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09562, KAKENHI-PROJECT-17K09671, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-15K09230
[Journal Article] Pre-existing interstitial lung disease as a risk factor for pneumonitis associated with ramucirumab and paclitaxel in patients with gastric cancer: the impact of usual interstitial pneumonia2018
- Author(s)
  Koyama N, Katayanagi S, Kawachi S.
- Journal Title
  
  PLOS ONE.
  
  Volume: 13 Issue: 6 Pages: e0198886-e0198886
- DOI
  10.1371/journal.pone.0198886
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09671
[Journal Article] High incidence and early onset of nivolumab-induced pneumonitis: four case reports and literature review2018
- Author(s)
  Koyama N.、Iwase O.、Nakashima E.、Kishida K.、Kondo T.、Watanabe Y.、Takahashi H.、Umebayashi Y.、Ogawa Y.、Miura H.
- Journal Title
  
  BMC Pulmonary Medicine
  
  Volume: 18 Issue: 1 Pages: 1-7
- DOI
  10.1186/s12890-018-0592-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09671
[Journal Article] Distinct benefit of overall survival between patients with non-small cell lung cancer harboring EGFR exon 19 deletion and exon 21 L858R substitution.2017
- Author(s)
  Koyama N, Watanabe Y, Iwai Y, Kawamura R, Miwa C, Nagai Y, Hagiwara K, Koyama S.
- Journal Title
  
  Chemotherapy
  
  Volume: 62 Issue: 3 Pages: 151-8
- DOI
  10.1159/000454944
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461195
[Journal Article] Treatment and outcomes of advanced/recurrent non-small cell lung cancer harboring the EGFR T790M mutation: a retrospective observational study of 141 patients in Japan.2016
- Author(s)
  Yamane Y, Shiono A, Ishii Y, Isobe K, Miyauchi E, Kishi K, Nishino M, Sugawara S, Ko R, Koyama N, Yabuki Y, Kobayashi K.
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 46 Pages: 1135-42
- DOI
  10.1093/jjco/hyw124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461195
[Journal Article] メトトレキサート関連リンパ腫様肉芽腫症の一剖検例2016
- Author(s)
  伊藤祥子，白石守，岩井悠希，三輪千尋，渡辺恭孝，小山信之，野首光弘，賀古真一，小山信一郎
- Journal Title
  
  自治医科大学紀要
  
  Volume: 38 Pages: 65-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461195
[Journal Article] Successful alectinib treatment for a mechanically ventilated patient with ALK-positive non-small cell lung cancer.2016
- Author(s)
  Watanabe Y, Koyama N, Iwai Y, Kawamura R, Miwa C, Nagai Y, Koyama S.
- Journal Title
  
  Annals of Cancer Research and Therapy
  
  Volume: 24 Pages: 47-51
- NAID
  130005285070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461195
[Journal Article] EGFR遺伝子変異陽性進行非小細胞肺癌に対する治療戦略2016
- Author(s)
  小山信之
- Journal Title
  
  東京医科大学雑誌
  
  Volume: 74 Pages: 256-67
- NAID
  40020988214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461195
[Journal Article] Clinical and biological significance of erlotinib therapy after pemetrexed in non-small cell lung cancer with wild-type EGFR.2015
- Author(s)
  Koyama N, Suzuki M.
- Journal Title
  
  Neoplasma
  
  Volume: 62 Issue: 06 Pages: 996-1004
- DOI
  10.4149/neo_2015_121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461195
[Journal Article] 一過性肺浸潤を認めた血管内悪性リンパ腫の1例2015
- Author(s)
  川村留美、渡辺恭孝、岩井悠希、白石守、三輪千尋、小山信之、小山信一郎
- Journal Title
  
  気管支学
  
  Volume: 37 Pages: 649-55
- NAID
  110010015649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461195
[Journal Article] Enhancer of Zeste Homolog 2 Is a Novel Prognostic Biomarker in Nons mall Cell Lung Cancer2012
- Author(s)
  Huqun, Rinako Ishikawa, Jialing Zhang, Hitoshi Miyazawa, Yoshiya Goto, Yoshihiko Shimizu, Koichi Hagiwara, Nobuyuki Koyama
- Journal Title
  
  Cancer
  
  Volume: 118 Issue: 6 Pages: 1599-606
- DOI
  10.1002/cncr.26441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591001, KAKENHI-PROJECT-22659163
[Journal Article] Enhancer of Zeste Homolog 2 Is a Novel Prognostic Biomarker in Nonsmall Cell Lung Cancer2011
- Author(s)
  Huqun, Ishikawa R, Zhang J, Miyazawa H, Goto Y, Shimizu Y, Hagiwara K, and Koyama N
- Journal Title
  
  Cancer
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591001
[Journal Article] ^<18> F-fluorodeoxyglucose positron emission tomography for relapsing polychondritis as a diagnostic approach and evaluation of disease activity2009
- Author(s)
  Yokoyama T, Koyama N, Kodama K, Hagiwara K, Kanazawa M
- Journal Title
  
  BMJ Case Reports
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591001
[Journal Article] Reliability of the peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based test for epidermal growth factor receptor gene mutations integrated into the clinical practice for non-small cell lung cancers.2007
- Author(s)
  Tanaka T., Nagai Y., Miyazawa H., Koyama N., Matsuoka S., Sutani A., Huqun, Udagawa K., Murayama Y., Nagata M., Shimizu Y., Ikebuchi K., Kanazawa M., Kobayashi K., Hagiwara K.
- Journal Title
  
  Cancer Science 98
  
  Pages: 246-52
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590738
[Journal Article] The Characterization of Gefitinib Sensitivity and Adverse Events in Patients with Non1small Cell Lung Cancer2006
- Author(s)
  Koyama N., Jinn Y., Takabe K., Yoshizawa M., Usui Y., Inase N., Miyake S., Yoshizawa Y., Hagiwara K., Kanazawa M.
- Journal Title
  
  Anticancer Research 26 (6B)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590738
[Journal Article] he Characterization of Gefitinib Sensitivity and Adverse Events in Patients with Non-small Cell Lung Cancer.2006
- Author(s)
  Koyama N
- Journal Title
  
  Anticancer Research 26
  
  Pages: 4519-4525
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590738
[Journal Article] The Characterization of Gefitinib Sensitivity and Adverse Events in Patients with Non-small Cell Lung Cancer.2006
- Author(s)
  Koyama N.
- Journal Title
  
  Anticancer Research 26
  
  Pages: 4519-25
- Data Source
  KAKENHI-PROJECT-16590738
[Journal Article] Gefitinib for non-small cell lung cancer patients with epidermal growth factor receptorgene mutations screened by peptide nucleic acid-locked nucleic acid PCR damp2006
- Author(s)
  Sutani A., Nagai Y., Udagawa K., Uchida Y., Koyama N., Murayama Y., Tanaka T., Miyazawa H., Nagata M., Kanazawa M., Hagiwara K., Kobayashi K.
- Journal Title
  
  British Journal of Cancer 95
  
  Pages: 1483-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590738
[Journal Article] A surviving case of Pulmonary Cunninghamella bertholletiae infection without surgical intervention
- Author(s)
  Koyama N., Nagata M., Hagiwara K., Kanazawa M.
- Journal Title
  
  Respirology (In Press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590738
[Journal Article] A surviving case of Pulmonary Cunninghamella bertholletiae infection without surgical intervention.
- Author(s)
  Koyama N.
- Journal Title
  
  Respirology In Press
- Data Source
  KAKENHI-PROJECT-16590738
[Journal Article] The homozygosity haplotype allows a genome-wide search for the autosomal segments shared among disease patients
- Author(s)
  Miyazawa H., Kato M., Awata T., Kohda M., Iwasa H., Koyama N., Tanaka T., Huqun, Kyo S., Okazaki Y., Hagiwara K.
- Journal Title
  
  American Joural of Human Genetics (In Press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590738
[Journal Article] A surviving case of Pulmonary Cunninghamella bertholletiae infection without surgical intervention.
- Author(s)
  Koyama N
- Journal Title
  
  Respirology (In Press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590738
[Presentation] Updated progression free survival (PFS) and survival (OS) of a Phase I/II Study of Nedaplatin and nab-Paclitaxel for Patients with Previously Untreated Advanced Squamous Cell Lung Cancer －KRSG 1302－2019
- Author(s)
  Ohyanagi F, Nagai Y, Kasai T, Koyama N, Kobayashi K, Hoshi E, Nakayama M, Mori K.
- Organizer
  2019 World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] 癌に対するラムシルマブ/パクリタキセル併用療法に伴う薬剤性肺障害の特徴2019
- Author(s)
  小山信之、片柳創、青柴和徹、中村博幸
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] A Phase I/II Study of Nedaplatin and nab-Paclitaxel for Patients with Previously Untreated Advanced Squamous cell Lung Cancer.2019
- Author(s)
  Sugiyama T, Kasai T, Koyama N, Kobayashi K, Hoshi E, Nakayama M, Mori K.
- Organizer
  第17回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] High Level of serum C-reactive protein predicts poor outcome in EGFR-TKI-treated patients with EGFR-mutated NSCLC.2019
- Author(s)
  Koyama N
- Organizer
  第17回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] 肺癌細胞のエネルギー代謝を浪費させる新規治療薬の開発2019
- Author(s)
  岩井悠希、菊池亮太、辻隆夫、小山信之、中村博幸、青柴和徹
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] miR-4448は小細胞肺癌のEZH2による上皮間葉転換を介した腫瘍増殖機能を阻害する2019
- Author(s)
  小山信之、石川雄一、岩井悠希、青柴和徹、中村博幸、萩原弘一
- Organizer
  第60回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] Mutual negative regulation of EZH2 and miR-4448 for tumor progression via epithelial mesenchymal transition in small cell lung cancer.2019
- Author(s)
  Koyama N, Ishikawa Y, Iwai Y, Aoshiba K, Nakamura H, Hagiwara K.
- Organizer
  American Association for Cancer Research Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] Reciprocal effect of EZH2 and miR-4448 on tumor growth via epithelial mesenchymal transition in small cell lung cancer2019
- Author(s)
  Koyama N, Ishikawa Y, Aoshiba K, Nakamura H, Hagiwara K.
- Organizer
  The 78th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] 800/15-ESI-09 and HJC0197, known EPAC inhibitors, sensitize lung cancer cells to glucose starvation by uncoupling mitochondrial electron transport, leading to bioenergetics crisis.2019
- Author(s)
  Iwai Y, Kikuchi R, Nakamura H, Koyama N, Hagiwara K, Aoshiba K.
- Organizer
  American Association for Cancer Research Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] Extracellular acidosis inhibits glucose starvation-induced lung cancer cell death by suppressing overall metabolic rate.2018
- Author(s)
  Iwai Y, Kikuchi R, Watanabe Y, Koyama N, Hagiwara K, Nakamura H, Aoshiba K.
- Organizer
  American Association for Cancer Research Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] Serum levels of C-reactive protein as a predictive factor for responses to EGFR-TKIs in patients with EGFR-mutated NSCLC.2018
- Author(s)
  Koyama N.
- Organizer
  The 77th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] 胃癌に対するラムシルマブ/パクリタキセル併用療法に伴う薬剤性肺臓炎の特徴2018
- Author(s)
  小山信之、片柳創、河地茂行
- Organizer
  第16回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] EGFR遺伝子変異陽性非小細胞肺癌におけるEGFR-TKI効果予測因子としての血清CRP2018
- Author(s)
  小山信之、内田修、高橋秀暢
- Organizer
  第59回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] Clinicopathological characteristics of NSCLC patients with nivolumab-induced pneumonitis.2017
- Author(s)
  Koyama N.
- Organizer
  International Association for the Study of Lung Cancer 18th World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] 当院のニボルマブ治療による肺障害発症例における臨床病理学的特徴2017
- Author(s)
  小山信之、岩瀬理、中嶋英治、岸田功典、渡辺恭孝、高橋秀暢、三浦弘之
- Organizer
  第15回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] 当院にてニボルマブ治療による肺障害を発症した非小細胞肺癌症例の臨床病理学的特徴2017
- Author(s)
  小山信之、中嶋英治、渡辺恭孝、高橋秀暢、三浦弘之
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09671
[Presentation] 間質性肺炎合併小細胞肺癌における治療の検討2016
- Author(s)
  岩井悠希、小山信之、渡辺恭孝、三輪千尋、長井良昭、萩原弘一、小山信一郎
- Organizer
  第56回日本呼吸器学会学術講演会
- Place of Presentation
  京都市
- Year and Date
  2016-04-08
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 当院の進展型肺小細胞癌における間質性肺炎の有無の影響および予後因子の検討2016
- Author(s)
  岩井悠希、渡辺恭孝、工藤史明、三輪千尋、長井良昭、太田洋充、小山信一郎、萩原弘一、小山信之
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡市
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 経気管支肺生検で診断された血管内大細胞型リンパ腫の2例2016
- Author(s)
  岩井悠希、渡辺恭孝、川村留美、三輪千尋、長井良昭、小山信之、小山信一郎、野首光弘
- Organizer
  第39回日本呼吸器内視鏡学会学術集会
- Place of Presentation
  名古屋市
- Year and Date
  2016-06-23
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] Prognostic factors in patients with advanced thymic carcinoma treated with chemotherapy: a retrospective analysis of 289 patients from NEJ023 Study.2016
- Author(s)
  Okuma Y, Ko R, Shukuya T, Tateishi K, Imai H, Miyauchi E, Fujiwara A, Sugiyama T, Azuma K, Muraki K, Yamasaki M, Tanaka H, Takashima Y, Soda S, Ishimoto O, Koyama N, Kuyama S, Murase K, Morita S, Takahashi K.
- Organizer
  The 2016 Annual Meeting of the American Society of Clinical Oncology
- Place of Presentation
  アメリカ　イリノイ州　シカゴ
- Year and Date
  2016-06-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 進行肺扁平上皮癌に対するnedaplatin+nab-paclitaxel併用第I/II相試験KRSG（関東呼吸器研究会）1302 study2016
- Author(s)
  笠井尚、森清志、小山信之、星永進、中山光男、小林国彦
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡市
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 乳癌化学療法におけるペグフィルグラスチム使用に対する後ろ向き検討2016
- Author(s)
  石川裕子、小山信之、高坂聡、天谷圭吾、柴崎ゆかり、森田春菜、吉元公一、奥山清、三坂武温、林光弘
- Organizer
  第54回日本癌治療学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-10-20
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] EGFR遺伝子変異非小細胞肺癌におけるExon1 9欠失の全生存期間延長2016
- Author(s)
  小山信之、渡辺恭孝、長井良昭、岩井悠希、川村留美、三輪千尋、工藤史明、萩原弘一、小山信一郎
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡市
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 進行非小細胞肺癌胸腹水貯留例のnab-PTXの効果の検討2016
- Author(s)
  岩井悠希、渡辺恭孝、川村留美、三輪千尋、長井良昭、萩原弘一、小山信一郎、小山信之
- Organizer
  第14回日本臨床腫瘍学会学術集会
- Place of Presentation
  神戸市
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] Effectiveness of nab-paclitaxel for malignant effusion in non-small cell lung cancer.2016
- Author(s)
  Iwai Y, Koyama N, Watanabe Y, Miwa C, Nagai Y, Koyama S.
- Organizer
  ESMO Asia 2016 Congress
- Place of Presentation
  シンガポール
- Year and Date
  2016-12-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 町田市と南町田病院における乳癌検診の現状2016
- Author(s)
  石川裕子、小山信之、後藤哲宏、佐々木健志、天谷圭吾、矢野正雄
- Organizer
  第26回日本乳癌検診学会学術総会
- Place of Presentation
  福岡県久留米市
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] Overall survival benefit in non-small cell lung cancer harboring EGFR exon 19 deletion.2016
- Author(s)
  Watanabe Y, Hagiwara K, Koyama N.
- Organizer
  The 75th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 当院における短時間少量補液(short hydration [SH])を用いたシスプラチン併用化学療法の安全性・有効性の検討2015
- Author(s)
  岩井悠希、小山信之、川村留美、三輪千尋、渡辺恭孝、長井良昭、萩原弘一、小山信一郎、鈴木栄
- Organizer
  第56回日本肺癌学会総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] EGFR遺伝子変異陽性非小細胞肺癌に対しEGFR-TKI投与後の再燃部位の検討2015
- Author(s)
  長井良昭、渡辺恭孝、岩井悠希、野村基子、川村留美、三輪千尋、小山信之、萩原弘一、小山信一郎
- Organizer
  第56回日本肺癌学会総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] Abundant expression of enhancer of zeste homolog 2 in small cell lung cancer2015
- Author(s)
  Yasutaka Watanabe, Nobuyuki Koyama, Yuki Iwai, Chihiro Miwa, Shinichiro Koyama
- Organizer
  American Association for Cancer Research Annual Meeting 2015
- Place of Presentation
  Philadelphia, PA, USA
- Year and Date
  2015-04-19
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] EGFR-TKIが投与されたEGFR遺伝子変異陽性非小細胞肺癌の再燃の検討2015
- Author(s)
  渡辺恭孝、小山信之、岩井悠希、川村留美、三輪千尋、小山信一郎
- Organizer
  第13回日本臨床腫瘍学会学術集会
- Place of Presentation
  札幌市
- Year and Date
  2015-07-18
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 人工呼吸器管理中にアレクチニブを開始し著効したALK陽性肺腺癌の1例2015
- Author(s)
  渡辺恭孝，小山信之，岩井悠希，川村留美，三輪千尋，長井良昭，萩原弘一，小山信一郎
- Organizer
  第56回日本肺癌学会総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] Relationship between expression of enhancer of EZH2 and EMT in small cell lung cancer.2015
- Author(s)
  Watanabe Y, Koyama N, Muto Y, Suzuki K, Ishikawa Y, Hagiwara K.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 当院における高齢者非小細胞肺癌に対するEGFR-TKI使用症例の検討2015
- Author(s)
  岩井悠希、渡辺恭孝、野村基子、川村留美、三輪千尋、長井良昭、小山信之、小山信一郎
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] エルロチニブによる皮膚障害対策に対する予防効果の検討2015
- Author(s)
  鈴木栄、新津京介、北弥生、小山信之、堀口久光
- Organizer
  第45回日本病院薬剤師会学術大会
- Place of Presentation
  茨城県つくば市
- Year and Date
  2015-08-01
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 小細胞肺癌切除34症例の臨床的検討2014
- Author(s)
  渡辺恭孝、小山信之、岩井悠希、白石守、三輪千尋、坪地宏嘉、遠藤俊輔、小山信一郎
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪市
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] 小細胞肺癌切除34症例の臨床的検討2014
- Author(s)
  渡辺恭孝、小山信之、岩井悠希、白石守、川村留美、三輪千尋、坪地宏嘉、遠藤俊輔、小山信一郎
- Organizer
  第55回日本肺癌学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] EGFR gene mutation as a predicitive marker of the response to pemetrexed-based chemotherapy in non-small cell lung cancer2011
- Author(s)
  Koyama N, Ishikawa R, Miyazawa H, Hagiwara K and Kobayashi K
- Organizer
  The 102st American Association for Cancer Research Annual Meeting 2011
- Place of Presentation
  オーランド, USA
- Year and Date
  2011-04-02
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] I期非小細胞肺癌に対する予後因子としてのEZH2:発現と機能解析2011
- Author(s)
  小山信之
- Organizer
  第6回肺癌分子病態研究会
- Place of Presentation
  東京、日本(招待講演)
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] 当院における高齢者に対する気管支鏡検査の検討2011
- Author(s)
  小山信之、嶺崎祥平、前野有理、山崎進、内田由佳、加賀亜希子、岡野哲也、村山芳武、小林国彦
- Organizer
  第34回日本呼吸器内視鏡学会学術集会
- Place of Presentation
  静岡
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] I期非小細胞肺癌に対する予後因子としてのEZH2 :発現と機能解析2011
- Author(s)
  小山信之
- Organizer
  第6回肺癌分子病態研究会
- Place of Presentation
  東京
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] 悪性胸膜中皮腫におけるHYAL2 DNAプロモーター領域のメチル化解析2010
- Author(s)
  小山信之、貞方里奈子、張嘉玲、呼群、後藤義也、清水禎彦、小林国彦、石川雄一、萩原弘一
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] HYAL2 promoter methylation analysis in malignant pleural mesothelioma2010
- Author(s)
  Sadakata R, Miyazawa H, Jialing Z, Huqun, Gotoh Y, Shimizu Y, Kobayashi K, Ishikawa Y, Hagiwara K, and Koyama N
- Organizer
  第68日本癌学会学術総会
- Place of Presentation
  神奈川
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] 非小細胞肺癌症例へのPemetrexed治療に対する臨床的検討2010
- Author(s)
  小山信之、長井良昭、内田義孝、前野有理、嶺崎祥平、内田由佳、大谷秀雄、村山芳武、小林国彦
- Organizer
  第51回日本肺癌学会総会
- Place of Presentation
  広島
- Year and Date
  2010-11-03
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] 当院における再発・進行非小細胞肺癌症例に対するerlotinib治療の臨床的検討2010
- Author(s)
  内田義孝、小山信之、小宮山謙一郎、嶺崎祥平、内田由佳、宮下起幸、前野有理、大谷秀雄、村山芳武、小林国彦
- Organizer
  第51回日本肺癌学会総会
- Place of Presentation
  広島
- Year and Date
  2010-11-03
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] Hypermethylation of semaphorin 3B promoter in malignant mesothlioma2010
- Author(s)
  Koyama N, Zhang J, Sadakata R, Goto Y, Shimizu Y, Kobayashi K, Ishikawa Y, Hagiwara K
- Organizer
  The 101st American Association for Cancer ResearchAnnual Meeting 2010
- Place of Presentation
  ワシントンD. C, USA
- Year and Date
  2010-04-17
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] 悪性胸膜中皮腫のSemaphorin 3Bプロモーター領域DNAメチル化解析2009
- Author(s)
  小山信之、張嘉玲、呼群、石川雄一、小林国彦、萩原弘一
- Organizer
  第50回日本肺癌学会総会
- Place of Presentation
  東京
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] Enhancer zeste homolog(EZH)2 expression reduces the survival of the patients with non-small cell lung cancer2009
- Author(s)
  小山信之
- Organizer
  100th American Association for Cancer Research
- Place of Presentation
  Denver CO USA
- Year and Date
  2009-04-22
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] Ezh2と肺癌2009
- Author(s)
  小山信之
- Organizer
  内蒙古医学院セミナー
- Place of Presentation
  中国
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] Ezh2と肺癌2009
- Author(s)
  小山信之
- Organizer
  内蒙古医学院セミナー
- Place of Presentation
  呼和浩得内蒙古自治区中国
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] Enhancer zeste homolog(EZH) 2 expression reduces the survival of the patients with non-small cell lung cancer2009
- Author(s)
  Koyama N, Huqun
- Organizer
  100th American Association for Cancer Research
- Place of Presentation
  Denver CO USA
- Year and Date
  2009-04-22
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] 悪性胸膜中皮腫におけるSemaphorin 3Bプロモーター領域のDNAメチル化解析2009
- Author(s)
  小山信之、張嘉玲、呼群、石川雄一、小林国彦、萩原弘一
- Organizer
  第68日本癌学会学術総会
- Place of Presentation
  神奈川
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-21591001
[Presentation] 悪性胸膜中皮腫におけるSEMA3Bメチル化解析2009
- Author(s)
  小山信之、張嘉玲、呼群、石川雄一、小林国彦、萩原弘一
- Organizer
  第49回日本呼吸器学会学術講演会
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-21591001

1. ENDOU Shunsuke (10245037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. ISHIKAWA Yuichi (80222975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. TSUBOCHI Hiroyoshi (50406055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 臼井裕 (30292965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. WATANABE Yasutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
6. 小村豪

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 小林国彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOYAMA NOBUYUKI 小山 信之

NOBUYUKI KOYAMA 小山 信之

KOYAMA Nobuyuki 小山 信之

Research Projects

Research Products

Co-Researchers

Elucidation of transcriptional regulatory mechanism defining the onset and progression of lung cancer with comorbid interstitial pneumonia and its application for its therapeutic applicationPrincipal Investigator

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Elucidation of the lncRNA-mediated mechanism underlying the onset and progression of lung cancer associated with interstitial pneumonia and development of biomarkersPrincipal Investigator

Principal Investigator

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Identification of microRNA underying the common pathogenic mechanism of lung cancer and interstitial pneumonia and establishment of a basis for its therapeutic applicationPrincipal Investigator

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Identification of a factor determining invasion and metastasis in non-small cell lung cancer and its therapeutic application based on comprehensive microRNA analysisPrincipal Investigator

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Exploration of a prognostic biomarker for lung cancer as personalized medicine using a genome-wide approachPrincipal Investigator

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Indentification of a novel lung cancer-associated factor and elucidation of the mechanism for cancer pathology using genome and proteome analysesPrincipal Investigator

Principal Investigator

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ゲノム・プロテオーム解析による新規肺癌関連因子の同定と癌病態機構の解明Principal Investigator

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Research Institution

[Book] Drug-Induced Lung Injury2017

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[Book] 気管支喘息の診断と治療&#12316;COPD合併例を含めて&#12316;2016

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[Book] 肺癌薬物療法の進歩と支持療法2016

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[Book] Chapter 14 Common pathways in IPF and lung cancer. Idiopathic Pulmonary Fibrosis - Advances in Diagnostic Tools and Disease Management2015

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[Journal Article] Serum C-reactive protein level predicts clinical outcomes in patients with non-small cell lung cancer harboring EGFR mutations.2020

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[Journal Article] Simultaneous metastasized primary unknown signet ring cell carcinoma of the cervical lymph node and mucoepidermoid carcinoma of the parotid gland as double cancers.2020

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[Journal Article] Pulmonary mucoepidermoid carcinoma arising in a patient with Kartagener syndrome.2020

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KOYAMA NOBUYUKI 小山信之

NOBUYUKI KOYAMA 小山信之

KOYAMA Nobuyuki 小山信之

[Book] 気管支喘息の診断と治療〜COPD合併例を含めて〜2016