HANDA Setsuko 半田節子

Researcher Number	30360697
Affiliation (based on the past Project Information) *help	2010 – 2011: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 助手 2010: 地方独立行政法人東京都健康長寿医療センター, 研究所, 助手 2009: 地方独立行政法人東京都健康長寿医療センター(東京都, 助手 2009: 東邦大学, 東京都健康長寿医療センター研究所, 助手 2008: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 助手 … More 2007 – 2008: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 助手 2007: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, 東京都老人総合研究所, Research Assistant 2005 – 2006: Tokyo Metropolitan Foundation for Research on Aging And Promotion of Human Welfare, Research assistant, 東京都老人総合研究所, 助手 2004: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Research assistant, 福祉振興財団・東京都老人総合研究所, 助手 2003: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所・加齢臓器障害研究グループ, 研究助手 2003: 財団法人東京都高齢者研究, 福祉振興財団・東京都老人総合研究所・加齢臓器障害研究グループ, 研究助手 Less
Review Section/Research Field	Principal Investigator 細胞死(アポトーシス) / Human pathology / Food science Except Principal Investigator Human pathology / Experimental pathology / Respiratory organ internal medicine
Keywords	Principal Investigator SMP30 / Akt / ノックアウトマウス / 老化 / ビタミンC / gluconolactonase / vitamin C / knockout mice / liver / aging … More / apoptosis / アクチノマイシンD / TNF-α / グルコノラクトナーゼ / 肝臓 / アポトーシス / 診断薬 / プロテオーム / PAD / シトルリン化 / アルツハイマー病 / 脳・神経 / ストレス / コラーゲン / ノックアウト / 活性酸素 / 酸化ストレス / アスコルビン酸 / カルニチン … More Except Principal Investigator astrocyte / citrullinated protein / Alzheimer's disease / neurodegenerative disorder / アストロサイト / シトルリン化蛋白質 / アルツハイマー病 / 神経変性疾患 / 老化 / arginine / calcium / apoptosis / neuron / アルギニン / カルシウム / アポトーシス / ニューロン / proteome / aging / myelin basic protein / peptidylarginine deiminase / グリア細胞 / チュブリン / シトルリン / 脱イミノ化蛋白質 / 蛋白質脱イミノ化酵素 / プロテオーム / ミエリン塩基性蛋白質 / ペプチジルアルギニンデイミナーゼ / 肺疾患 / COPD / ビタミンC / 慢性閉塞性肺疾患 / 閉塞性肺疾患 Less

Pathological analysis of PAD and citrullinated proteins that triggers the onset of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  HANDA Setsuko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Pathogenesis and drug development using a mouse model of chronic obstructive pulmonary disease
- Principal Investigator
  
  ISHIGAMI Akihito
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所)
  Toho University
Influence of vitamin C deficiency exerts on aging, nervous system, energy metabolism and lipid metabolismPrincipal Investigator
- Principal Investigator
  
  HANDA Setsuko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
The elucidation of onset mechanism of Alzheimer's disease.
- Principal Investigator
  
  ISHIGAMI Akihito
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
The elucidation of the apoptosis inhibitory action of SMP30.Principal Investigator
- Principal Investigator
  
  HANDA Setsuko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  細胞死(アポトーシス)
- Research Institution
  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
Molecular pathological analysis of citrullinated proteins in the brain from neurodegenerative disorder patients.
- Principal Investigator
  
  ISHIGAMI Akihito
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology

All 2011 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Establishment and characterization of hepatocytes from an Immortomouse/SMP30/GNL knockout mouse hybrid lacking vitamin C to study vitamin C transport2011
- Author(s)
  Amano, A., Handa, S., Aigaki, T., Shigemoto, K., Maruyama, N., Ishigami, A.
- Journal Title
  
  Journal of biochemistry
  
  Volume: 150 Issue: 6 Pages: 671-678
- DOI
  10.1093/jb/mvr109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04778, KAKENHI-PROJECT-21200023, KAKENHI-PROJECT-21590974, KAKENHI-PROJECT-21591102, KAKENHI-PROJECT-23791009, KAKENHI-PROJECT-24390228
[Journal Article] カルニチン生合成系へのビタミンCの関与2009
- Author(s)
  古澤元、佐藤安訓、田中康一、井内陽子、天野晶子、岩間水輝、近藤嘉高、半田節子、村田晃、錦見盛光、後藤佐多良、丸山直記、高橋良哉、石神昭人
- Journal Title
  
  ビタミン 83
  
  Pages: 287-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580156
[Journal Article] Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 cells2009
- Author(s)
  Handa, et.al.
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 1645-1648
- NAID
  130000116921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590392
[Journal Article] Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 cells2009
- Author(s)
  Handa, S., Maruyama, N. and Ishigami, A.
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 32 Pages: 1645-1648
- NAID
  130000116921
- URL
  http://dx.doi.org/10.1248/bpb.32.1645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590392
[Journal Article] Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 cells2009
- Author(s)
  Handa, S., Maruyama, N. and Ishigami, A
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 32 Pages: 1645-1648
- NAID
  130000116921
- URL
  http://dx.doi.org/10.1248/bpb.32.1645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590974
[Journal Article] Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis2009
- Author(s)
  Son, T. G., Park, H. R., Kim, S. J., Kim, K., Kim, MS., Ishigami, A., Handa, S., Maruyama, N. Chung, H. Y. and Lee, J
- Journal Title
  
  J. Neurosci. Res
  
  Volume: 87 Issue: 13 Pages: 2890-2897
- DOI
  10.1002/jnr.22122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590392, KAKENHI-PROJECT-21590974
[Journal Article] Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 cells2009
- Author(s)
  Handa, et. al.
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 1645-1648
- NAID
  130000116921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590974
[Journal Article] Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice.2008
- Author(s)
  Kondo, Y., Sasaki, T., Sato, Y., Amano, A., Iwama, M., Handa, S., Shimada, N., Fukuda, M., Akita, M., Lee, J., Jeong, KS., Maruyama, N. and Ishigami, A.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 377
  
  Pages: 291-296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580156
[Journal Article] Vitamin C is not essential for carnitine biosynthesis in vivo: Verification in vitamin C-depleted SMP30/GNL knockout mice.2008
- Author(s)
  Furusawa, H., Sato, Y., Tanaka, Y., Inai, Y., Amano, A., Iwama, M., Kondo, Y., Handa, S., Murata, A., Nishikimi, M., Goto, S., Maruyama, N., Takahashi, R. and Ishigami, A.
- Journal Title
  
  Biol. Pharm. Bull. 31
  
  Pages: 1673-1679
- NAID
  110007338150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580156
[Journal Article] Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.2008
- Author(s)
  Sato, Y., Kajiyama, S., Amano, A., Kondo, Y., Sasaki, T., Handa, S., Takahashi, R., Fukui, M., Hasegawa, G., Nakamura, N., Fujinawa, H., Mori, T., Ohta, M., Obayashi, H., Maruyama, N. and Ishigami, A.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 375
  
  Pages: 346-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580156
[Journal Article] Accelerated tubular cell senescence in SMP30 knockout mice.2006
- Author(s)
  Yumura, W., Imasawa, T., Suganuma, S., Ishigami. A., Handa, S., Kubo, S. and Maruyama, N.
- Journal Title
  
  Histol. Histopathol. 21
  
  Pages: 1151-1156
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590355
[Journal Article] Senescence Marker Protein 30 Functions as Gluconolactonase in L-Ascorbic Acid Biosynthesis and Its Knockout Mice Are Prone to Scurvy.2006
- Author(s)
  Kondo, Y., Inai, Y., Sato, Y., Handa, S., Kubo, S., Shimokado, K., Goto, S., Nishikimi, M., Maruyama, N., and Ishigami, A.
- Journal Title
  
  Proc. Nat. Acad. Sci. USA 103
  
  Pages: 5723-5728
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590355
[Journal Article] Senescence Marker Protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells.2005
- Author(s)
  Ishigami, A., Fujita, T., Inoue, H., Handa, S., Kubo, S., Kondo, Y., Maruyama, N.
- Journal Title
  
  Cell & Tissue Res. 320
  
  Pages: 243-249
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15603010
[Journal Article] Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate (DFP) in the liver.2004
- Author(s)
  Kondo, Y., Ishigami, A., Kubo, S., Handa, S.et al.
- Journal Title
  
  FEBS Lett. 570
  
  Pages: 57-62
- Data Source
  KAKENHI-PROJECT-15603010
[Journal Article] SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.2004
- Author(s)
  Ishigami, A., Kondo, Y., Nanba, R., Ohsawa, T., Handa, S.et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 315
  
  Pages: 575-580
- NAID
  40006236477
- Data Source
  KAKENHI-PROJECT-14570210
[Journal Article] SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.2004
- Author(s)
  Ishigami, A., Kondo, Y., Nanba, R., Ohsawa, T., Handa, S.et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 315
  
  Pages: 575-580
- NAID
  40006236477
- Data Source
  KAKENHI-PROJECT-15603010
[Journal Article] Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate (DFP) in the liver.2004
- Author(s)
  Kondo, Y., Ishigami, A., Kubo, S., Handa, S.et al.
- Journal Title
  
  FEBS Lett. 570
  
  Pages: 57-62
- Data Source
  KAKENHI-PROJECT-14570210
[Journal Article] Senescence Marker Protein-30 Knockout Mouse as an Aging Model.2004
- Author(s)
  Maruyama, N., Ishigami, A., Kuramoto, M., Handa, S.et al.
- Journal Title
  
  Ann.NY Acad.Sci. 1019
  
  Pages: 383-387
- Data Source
  KAKENHI-PROJECT-14570210
[Journal Article] Senescence Marker Protein-30 Knockout Mouse as an Aging Model.2004
- Author(s)
  Maruyama, N., Ishigami, A., Kuramoto.M..Handa.S.et al.
- Journal Title
  
  Ann.NY Acad.Sci. 1019
  
  Pages: 383-387
- Data Source
  KAKENHI-PROJECT-15603010
[Journal Article] Accelerated tubular cell senescence in SMP30 knockout mice.
- Author(s)
  Yumura, W, Imasawa, T., Suganuma, S., Ishigami, A., Handa, S., Kubo, S., Maruyama, N.
- Journal Title
  
  Histol.Histopathol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15603010
[Presentation] ビタミンC欠乏マウスにおける活性酸素種は増加する2011
- Author(s)
  近藤嘉高、加賀美弥生、半田節子、石神昭人、丸山直記
- Organizer
  第65回日本栄養・食糧学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590974
[Presentation] マウス肝臓におけるSMP30/GNLの組織学的加齢変化2008
- Author(s)
  半田節子、島田信子、天野晶子、福田貢、近藤嘉高、丸山直記、石神昭人
- Organizer
  第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19580156
[Presentation] ビタミン C欠乏による SVCT1および SVCT2発現調節の検討2008
- Author(s)
  天野晶子、島田信子、岩間水輝、福田貢、半田節子
- Organizer
  第60回日本ビタミン学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19580156
[Presentation] ビタミンC生合成経路で働く酵素グルコノラクトナーゼ (SMP30/GNL)の加齢変化2008
- Author(s)
  天野晶子、近藤嘉高、岩間水輝、佐藤安訓、半田節子、相垣敏郎、石神昭人
- Organizer
  第62回日本栄養・食糧学会
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-19580156
[Presentation] デジタル老化説-マウス肝臓におけるSMP30の加齢変化-.2007
- Author(s)
  半田節子, 他
- Organizer
  第30回日本基礎老化学会
- Place of Presentation
  札幌
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590355
[Presentation] デジタル老化説-マウス肝臓におけるSMP30の加齢変化-.2007
- Author(s)
  半田節子, 他
- Organizer
  第30回日本基礎老化学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19580156
[Presentation] デジタル老化説-マウス肝臓におけるSMP30の加齢変化-.2007
- Author(s)
  半田節子, 他
- Organizer
  第30回日本基礎老化学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-18590355
[Presentation] デジタル老化説-マウス肝臓におけるSMP30の加齢変化-2007
- Author(s)
  半田節子、久保幸穂、福田貢、丸山直記、石神昭人
- Organizer
  第30回日本基礎老化学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19580156

1. ISHIGAMI Akihito (50270658)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
2. MARUYAMA Naoki (00115940)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 久保幸穂 (00280769)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 浅賀宏昭 (80231877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大沢多加子 (20073017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

HANDA Setsuko 半田 節子

Research Projects

Research Products

Co-Researchers

Pathological analysis of PAD and citrullinated proteins that triggers the onset of Alzheimer's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenesis and drug development using a mouse model of chronic obstructive pulmonary disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Influence of vitamin C deficiency exerts on aging, nervous system, energy metabolism and lipid metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The elucidation of onset mechanism of Alzheimer's disease.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The elucidation of the apoptosis inhibitory action of SMP30.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathological analysis of citrullinated proteins in the brain from neurodegenerative disorder patients.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Establishment and characterization of hepatocytes from an Immortomouse/SMP30/GNL knockout mouse hybrid lacking vitamin C to study vitamin C transport2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] カルニチン生合成系へのビタミンCの関与2009

Author(s)

Journal Title

Data Source

[Journal Article] Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 cells2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 cells2009

Author(s)

Journal Title

NAID

URL

Data Source

[Journal Article] Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 cells2009

Author(s)

Journal Title

NAID

URL

Data Source

[Journal Article] Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis2009

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 cells2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice.2008

Author(s)

Journal Title

Data Source

HANDA Setsuko 半田節子