Miyoshi Hiroyuki 三好弘之

… Alternative Names

三好弘之ミヨシヒロユキ

MIYOSHI Hiroyuki 三好弘之

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Researcher Number	30362479
Other IDs	https://orcid.org/0000-0001-7400-0714
Affiliation (Current)	2024: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2022: 京都大学, 医学研究科, 准教授 2019 – 2020: 京都大学, 医学研究科, 准教授 2018: 京都大学, 産官学連携本部, 特任准教授 2009: 京都大学, 医学研究科, 助教 2006 – 2007: 京都大学, 医学研究科, 助教 2003 – 2006: 京都大学, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 49030:Experimental pathology-related / Experimental pathology Except Principal Investigator Biological Sciences / Pathological medical chemistry
Keywords	Principal Investigator スフェロイド / LKB1 / マーカー遺伝子 / 分化 / 幹細胞 / 大腸がん / Wnt / がん幹細胞 / 癌幹細胞 / 組織幹細胞 … More / スフェロイド培養 / エピジェネティクス / Microarray / Mouse / Kinase / Hepatocellular carcinoma / マイクロアレイ / マウス / キナーゼ / 肝臓癌 … More Except Principal Investigator COX-2 / マイクロアレイ / 病理学 / 癌 / トランスジェニックマウス / APC / 間質細胞 / Apc / Lkb1 / 血管新生 / LKB1 / CXCR3 / ケモカイン / 転移 / LKB 1 / Pathology / Cancer / Transgenic mouse / Stromal cells / Prostaglandin / EP2 / PGE_2 / cPLA2 / ポリープ / β-catenin / Smad2 / ノックアウトマウス / 肝癌 / 大腸癌 / TGF-βシグナル / 線維芽細胞 / Fhit / プロスタグランジン / Notch / 細胞・組織 / 分子腫瘍学 / MMP7 / mTORC1 / 遺伝子改変マウス / シグナル伝達 / 炎症 / mPGES / LYVE-1 / リンパ管新生 / B16F10 / mTOR / Cdx2 / プロテオミクス / マクロファージ / 染色体不安定性 / Wnt / CDX2 / CCL9 / CCR1 / 同所移植 / 浸潤 Less

大腸上皮の分化指標に基づく大腸がん予後予測新規因子の解明Principal Investigator
- Principal Investigator
  
  三好弘之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyoto University
Investigation of epigenetic modifications that specify tissue identity of adult epithelial cellsPrincipal Investigator
- Principal Investigator
  
  Miyoshi Hiroyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kyoto University
Studies on digestive cancer metastasis using mouse models
- Principal Investigator
  
  TAKETO Makoto
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
The mechanisms of preneoplastic nodule formation in the liver by loss of LKB1Principal Investigator
- Principal Investigator
  
  MIYOSHI Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto University
Epitehial-stromal interactions and molecularly targeted therapy
- Principal Investigator
  
  TAKETO Makoto
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
消化器癌の転移機構とその治療の研究
- Principal Investigator
  
  TAKETO Makoto
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Kyoto University
Epithelium-stroma interactions in carcinogenesis
- Principal Investigator
  
  TAKETO Makoto Mark
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  KYOTO UNIVERSITY

All 2023 2020 2018 2010 2009 2007 2006 2005 2002

All Journal Article Presentation

[Journal Article] Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy2020
- Author(s)
  Yamamoto Takehito、Miyoshi Hiroyuki、Kakizaki Fumihiko、Maekawa Hisatsugu、Yamaura Tadayoshi、Morimoto Tomonori、Katayama Toshiro、Kawada Kenji、Sakai Yoshiharu、Taketo M. Mark
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 8 Pages: 2010-2010
- DOI
  10.3390/cancers12082010
- NAID
  120006888015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02639
[Journal Article] M. CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium.2010
- Author(s)
  Kakizaki, F., Aoki, K., Miyoshi, H., Carrasco, N., Aoki, M., Taketo, M.
- Journal Title
  
  Gastroenterology 138
  
  Pages: 627-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016032
[Journal Article] Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb 1+/-mice.2009
- Author(s)
  Miyoshi, H., et al.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 2046-2053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016032
[Journal Article] Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1 mice.2009
- Author(s)
  Miyoshi, H., Deguchi, A., Nakau, M., Kojima, Y., Mori, A., Oshima, M., Aoki, M., Taketo, M.M.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 2046-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016032
[Journal Article] SMAD4-deficient intestinal tumors recruit CCR1+-myeloid cells that help invasion.2007
- Author(s)
  Kitamura, T., Kometani, K., Hashida, H., Matsunaga, A., Miyoshi, H., Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., Minato, M., Taketo, M.M.
- Journal Title
  
  Nat. Genet. 39
  
  Pages: 467-475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016032
[Journal Article] Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells.2007
- Author(s)
  Aoki, K., Aoki, M., Sugai, M., Harada, N., Miyoshi, H., Tsukamoto, T., Mizoshita, T., Tatematsu, M., Seno, H., Chiba, T., Oshima, M., Hsieh, C.L., Taketo, M.M.
- Journal Title
  
  Oncogene 26
  
  Pages: 3511-3520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016032
[Journal Article] Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity regulating kinases signaling.2007
- Author(s)
  Kojima, Y., Miyoshi, H., Clevers, H.C., Oshima, M., Aoki, M., Taketo, M.M.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 23532-23540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016032
[Journal Article] Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice.2006
- Author(s)
  Takeda, H., Miyoshi, H., Kojima, Y., Oshima, M., Taketo, M.M.
- Journal Title
  
  Oncogene 25
  
  Pages: 1816-1820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016032
[Journal Article] A targeted mutation of Nkd1 impairs mouse spermatogenesis.2005
- Author(s)
  Li, Q., Ishikawa, T., Miyoshi, H., Oshima, M., Taketo, M.M.
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 2831-2839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016032
[Journal Article] Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.2002
- Author(s)
  Miyoshi, H et al.
- Journal Title
  
  Cancer Research 62(8)
  
  Pages: 2261-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219203
[Journal Article] Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.2002
- Author(s)
  H.Miyoshi
- Journal Title
  
  Cancer Research 62巻・8号
  
  Pages: 2261-2266
- Data Source
  KAKENHI-PROJECT-14GS0316
[Journal Article] Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.2002
- Author(s)
  Miyoshi, H.et al.
- Journal Title
  
  Cancer Research 62・8
  
  Pages: 2261-2266
- Data Source
  KAKENHI-PROJECT-12219203
[Journal Article] Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.2002
- Author(s)
  Miyoshi, K et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the US A 99(1)
  
  Pages: 219-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219203
[Journal Article] Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.2002
- Author(s)
  Miyoshi K et al.
- Journal Title
  
  Proceeding of the National Academy of Sciences of the USA 99
  
  Pages: 219-224
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219203
[Journal Article] Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.2002
- Author(s)
  Miyoshi H et al.
- Journal Title
  
  Cancer Research 62
  
  Pages: 2261-2266
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219203
[Presentation] 患者由来消化管上皮幹細胞を用いた個別化医療開発2023
- Author(s)
  三好弘之
- Organizer
  日本生理学会　第100回記念大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07187
[Presentation] 高効率で低コストの患者由来大腸がんスフェロイド培養法2018
- Author(s)
  三好　弘之
- Organizer
  日本癌学会総会
- Data Source
  KAKENHI-PROJECT-18H02639

1. TAKETO Makoto (70281714)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. AOKI Masahiro (60362464)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. KITAMURA Takanori (10378622)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
4. OSHIMA Masanobu (40324610)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
5. SONOSHITA Masahiro (80511857)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 石川智夫 (70322162)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 高久和明 (90313121)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OSHIMA Hiroko (80362515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. DEGUCHI Atsuko (10422932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Miyoshi Hiroyuki 三好 弘之

三好 弘之 ミヨシ ヒロユキ

MIYOSHI Hiroyuki 三好 弘之

Research Projects

Research Products

Co-Researchers

大腸上皮の分化指標に基づく大腸がん予後予測新規因子の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of epigenetic modifications that specify tissue identity of adult epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on digestive cancer metastasis using mouse models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanisms of preneoplastic nodule formation in the liver by loss of LKB1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epitehial-stromal interactions and molecularly targeted therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

消化器癌の転移機構とその治療の研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Epithelium-stroma interactions in carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] M. CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium.2010

Author(s)

Journal Title

Data Source

[Journal Article] Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb 1+/-mice.2009

Author(s)

Journal Title

Data Source

[Journal Article] Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1 mice.2009

Author(s)

Journal Title

Data Source

[Journal Article] SMAD4-deficient intestinal tumors recruit CCR1+-myeloid cells that help invasion.2007

Author(s)

Journal Title

Data Source

[Journal Article] Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells.2007

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity regulating kinases signaling.2007

Author(s)

Journal Title

Data Source

[Journal Article] Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice.2006

Author(s)

Journal Title

Miyoshi Hiroyuki 三好弘之

三好弘之ミヨシヒロユキ

MIYOSHI Hiroyuki 三好弘之