MITSUYOSHI Hironori 光吉博則

Researcher Number	30363972
Other IDs
Affiliation (based on the past Project Information) *help	2014: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2012 – 2013: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Gastroenterology
Keywords	Principal Investigator NASH / NLRP3 / inflammasome / 非アルコール性脂肪性肝疾患

Analysis of dysregulated lipid and iron metabolisms in patients with nonalcoholic fatty liver diseasePrincipal Investigator
- Principal Investigator
  
  MITSUYOSHI Hironori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high-fat diet fed mice2015
- Author(s)
  Yamaguchi K, Nishimura T, Ishiba H, Seko Y, Okajima A, Fujii H, Tochiki N, Umemura A, Moriguchi M, Sumida Y, Mitsuyoshi H, Yasui K, Minami M, Okanoue T, Itoh Y
- Journal Title
  
  Liver Int
  
  Volume: 35 Issue: 2 Pages: 550-61
- DOI
  10.1111/liv.12645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590990
[Journal Article] Effect of PNPLA3 rs738409 variant (I148M) on hepatic steatosis, necroinflammation, and fibrosis in Japanese patients with chronic hepatitis C2014
- Author(s)
  Yasui K, Kawaguchi T, Shima T, Mitsuyoshi H, Seki K, Sendo R, Mizuno M, Itoh Y, Matsuda F, Okanoue T
- Journal Title
  
  J Gastroenterol
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590990
[Journal Article] The 'donations for decreased ALT (D4D)' prosocial behavior incentive scheme for NAFLD patients2014
- Author(s)
  Sumida Y, Yoshikawa T, Tanaka S, Taketani H, Kanemasa K, Nishimura T, Yamaguchi K, Mitsuyoshi H, Yasui K, Minami M, Naito Y, Itoh Y
- Journal Title
  
  Public Health
  
  Volume: 36 Issue: 4 Pages: 629-34
- DOI
  10.1093/pubmed/fdt098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590990
[Journal Article] Predictors of malignancies and overall mortality in Japanese patients with biopsy-proven non-alcoholic fatty liver disease2014
- Author(s)
  Seko Y, Sumida Y, Tanaka S, Taketani H, Kanemasa K, Ishiba H, Okajima A, Nishimura T, Yamaguchi K, Moriguchi M, Mitsuyoshi H, Yasui K, Minami M, Itoh Y
- Journal Title
  
  Hepatol Res
  
  Volume: - Issue: 7 Pages: 728-738
- DOI
  10.1111/hepr.12407
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590990, KAKENHI-PROJECT-15K09017
[Journal Article] Serum alanine aminotransferase predicts the histological course of non-alcoholic steatohepatitis in Japanese patients2014
- Author(s)
  Seko Y, Sumida Y, Tanaka S, Mori K, Taketani H, Ishiba H, Hara T, Okajima A, Yamaguchi K, Moriguchi M, Mitsuyoshi H, Kanemsa K, Yasui K, Minami M, Imai S, Itoh Y
- Journal Title
  
  Hepatol Res
  
  Volume: - Issue: 10
- DOI
  10.1111/hepr.12456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590990
[Journal Article] Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma.2014
- Author(s)
  Dohi O, Yasui K, Gen Y, Takada H, Endo M, Tsuji K, Konishi C, Yamada N, Mitsuyoshi H, Naito Y, Tanaka S, Arii S, Yoshikawa T.
- Journal Title
  
  Int J Oncol,
  
  Volume: 42(2) Issue: 2 Pages: 411-418
- DOI
  10.3892/ijo.2012.1724
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130005, KAKENHI-PROJECT-22249050, KAKENHI-PROJECT-23590470, KAKENHI-PROJECT-24590990, KAKENHI-PROJECT-25253081
[Journal Article] Lower levels of insulin-like growth factor-1 standard deviation score are associated with histological severity of non-alcoholic fatty liver disease2014
- Author(s)
  Sumida Y, Yonei Y, Tanaka S, Mori K, Kanemasa K, Imai S, Taketani H, Hara T, Seko Y, Ishiba H, Okajima A, Yamaguchi K, Moriguchi M, Mitsuyoshi H, Yasui K, Minami M, Itoh
- Journal Title
  
  Hepatol Res
  
  Volume: - Issue: 7 Pages: 1-11
- DOI
  10.1111/hepr.12408
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590990, KAKENHI-PROJECT-26350917
[Journal Article] The 'donations fordecreased ALT (D4D)' prosocial behavior incentive scheme for NAFLD patients.2014
- Author(s)
  Sumida Y, Yoshikawa T, Tanaka S, Taketani H, Kanemasa K, Nishimura T,　Yamaguchi K, Mitsuyoshi H, Yasui K, Minami M, Naito Y, Itoh Y.
- Journal Title
  
  J　Public Health
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590990
[Journal Article] Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C.2013
- Author(s)
  Mitsuyoshi H, Yasui K, Yamaguchi K, Minami M, Okanoue T, Itoh Y.
- Journal Title
  
  Int J Hepatol
  
  Volume: Epub ahead of print Pages: 1-8
- DOI
  10.1155/2013/686420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590984, KAKENHI-PROJECT-24590990
[Journal Article] Rosuvastatin ameliorates high-fat and high-cholesterol diet-induced nonalcoholic steatohepatitis in rats2013
- Author(s)
  Okada Y, Yamaguchi K, Nakajima T, Nishikawa T, Jo M, Mitsumoto Y, Kimura H, Nishimura T, Tochiki N, Yasui K, Mitsuyoshi H, Minami M, Kagawa K, Okanoue T, Itoh Y
- Journal Title
  
  Liver Int
  
  Volume: 33 Issue: 2 Pages: 301-311
- DOI
  10.1111/liv.12033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590470, KAKENHI-PROJECT-23590984, KAKENHI-PROJECT-24590990
[Journal Article] Prediction of a favorable clinical course in hepatitis C virus carriers with persistently normal serum alanine aminotransferase levels: A long-term follow-up study2013
- Author(s)
  Nishimura T, Yamaguchi K, Fujii H, Okada Y, Yokomizo C, Niimi T, Sumida Y, Yasui K, Mitsuyoshi H, Minami M, Umemura A, Shima T, Okanoue T, Itoh Y.
- Journal Title
  
  Hepatol Res
  
  Volume: 43 Issue: 5 Pages: 557-562
- DOI
  10.1111/j.1872-034x.2012.01091.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590470, KAKENHI-PROJECT-24590990
[Journal Article] Aberrant expression of the PHF14 gene in biliary tract cancer cells.2013
- Author(s)
  Akazawa T, Yasui K, Gen Y, Yamada N, Tomie A, Dohi O, Mitsuyoshi H, Yagi N, Itoh Y, Naito Y, Yoshikawa T.
- Journal Title
  
  Oncol Lett
  
  Volume: 5 Pages: 1849-1853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590990
[Presentation] 非アルコール性脂肪性肝疾患（NAFLD）におけるInflammasomeの検討2015
- Author(s)
  光吉博則、安居幸一郎、原　祐、石破　博、岡嶋　亮、瀬古裕也、山口寛二、森口理久、角田圭雄、南　祐仁、伊藤義人
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  熊本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-24590990
[Presentation] C型肝炎におけるinflammasome活性化の検討2014
- Author(s)
  光吉博則　安居幸一郎　西村健　山口寛二　森口理久　角田圭雄　南祐仁　伊藤義人
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-24590990
[Presentation] Activation of the inflammasome is involved in the pathogenesis of chronic hepatitis C2013
- Author(s)
  Hironori Mitsuyoshi, Kohichiroh Yasui, Takeshi Nishimura, Kanji Yamaguchi, Yoshio Sumida, Masahito Minami, Yoshito Itoh
- Organizer
  American Association for the Study of Liver Diseases
- Place of Presentation
  Washinton
- Data Source
  KAKENHI-PROJECT-24590990
[Presentation] Distinctive pathogenic roles of iron deposition in hepatocytes and reticuloendothelial cells2012
- Author(s)
  Hironori Mitsuyoshi Kouichirou Yasui Kanji Yamaguchi et al.
- Organizer
  American Association for the Study of Liver diseases
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-24590990
[Presentation] C型慢性肝炎における鉄蓄積パターンの解析2012
- Author(s)
  光吉博則　安居幸一郎　山口寛二　ほか
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24590990

1. YASUI Kohichiroh (30323695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
2. MINAMI Masahito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 田中真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MITSUYOSHI Hironori 光吉 博則

Research Projects

Research Products

Co-Researchers

Analysis of dysregulated lipid and iron metabolisms in patients with nonalcoholic fatty liver diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high-fat diet fed mice2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of PNPLA3 rs738409 variant (I148M) on hepatic steatosis, necroinflammation, and fibrosis in Japanese patients with chronic hepatitis C2014

Author(s)

Journal Title

Data Source

[Journal Article] The 'donations for decreased ALT (D4D)' prosocial behavior incentive scheme for NAFLD patients2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predictors of malignancies and overall mortality in Japanese patients with biopsy-proven non-alcoholic fatty liver disease2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum alanine aminotransferase predicts the histological course of non-alcoholic steatohepatitis in Japanese patients2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lower levels of insulin-like growth factor-1 standard deviation score are associated with histological severity of non-alcoholic fatty liver disease2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The 'donations fordecreased ALT (D4D)' prosocial behavior incentive scheme for NAFLD patients.2014

Author(s)

Journal Title

Data Source

[Journal Article] Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rosuvastatin ameliorates high-fat and high-cholesterol diet-induced nonalcoholic steatohepatitis in rats2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prediction of a favorable clinical course in hepatitis C virus carriers with persistently normal serum alanine aminotransferase levels: A long-term follow-up study2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant expression of the PHF14 gene in biliary tract cancer cells.2013

Author(s)

Journal Title

Data Source

[Presentation] 非アルコール性脂肪性肝疾患（NAFLD）におけるInflammasomeの検討2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] C型肝炎におけるinflammasome活性化の検討2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Activation of the inflammasome is involved in the pathogenesis of chronic hepatitis C2013

MITSUYOSHI Hironori 光吉博則

[Presentation] C型慢性肝炎における鉄蓄積パターンの解析2012