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Ogiwara Ikuo  荻原 郁夫

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OGIWARA Ikuo  荻原 郁夫

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Researcher Number 30373286
Other IDs
Affiliation (Current) 2025: 日本医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 日本医科大学, 医学部, 准教授
2015 – 2017: 日本医科大学, 医学部, 准教授
2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 副チームリーダー
2013: 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員
2008 – 2012: The Institute of Physical and Chemical Research, 神経遺伝研究チーム, 研究員
2007: The Institute of Physical and Chemical Research, 神経遺伝研究チーム, 研究員
2004 – 2006: 独立行政法人理化学研究所, 神経遺伝研究チーム, 研究員
Review Section/Research Field
Principal Investigator
Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Psychiatric science
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Keywords
Principal Investigator
てんかん / 脳・神経 / 電位依存性ナトリウムチャネル / 神経科学 / ナトリウムチャネル遺伝子 / 脳神経疾患 / 興奮性神経細胞 / てんかん性脳症 / 抑制性神経細胞 / 疾患プロテオーム … More / 自閉症 / タンパク複合体 / タンパク質複合体 / ナトリウムチャネル / 自閉症スペクトラム障害 / 知的障害 / トランスレーショナルリサーチ / 精神発達障害 / インターニューロン … More
Except Principal Investigator
てんかん / GEFS+ / SMEI / SCN2A / 神経作動薬 / 根治薬 / チャネル / けいれん / ハイスループットスクリーニング / 創薬 / ハイスルーブットスクリーニング / 遺伝子改変動物 / iPS細胞 / Patch-clamp analysis / Nonsense mutation / Genes / Sodium channel / Epilepsy / GEFS_+ / パッチクランプ法 / ナンセンス変異 / 遺伝子 / ナトリウムチャネル Less
  • Research Projects

    (11 results)
  • Research Products

    (113 results)
  • Co-Researchers

    (16 People)
  •  Establishment of a practical pipeline to develop drugs for intractable epilepsies based on their uncovered molecular pathomechanisms

    • Principal Investigator
      廣瀬 伸一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Fukuoka University
  •  Protein-protein interactions as potential therapeutic targets for epileptic encephalopathyPrincipal Investigator

    • Principal Investigator
      荻原 郁夫
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nippon Medical School
  •  Fundamental Research for an Innovative Drug Discovery Based on the Molecular Pathomechanisms of Refractory Epilepsy Using a Multidimensional Approach.

    • Principal Investigator
      Hirose Shinichi
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Fukuoka University
  •  Proteins interacting with Nav1.1 may be potential therapeutic targets for epilepsyPrincipal Investigator

    • Principal Investigator
      Ogiwara Ikuo
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nippon Medical School
  •  Analysis of interacting-partners of Nav1.1 in premature mouse brainPrincipal Investigator

    • Principal Investigator
      OGIWARA Ikuo
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Psychiatric science
    • Research Institution
      Nippon Medical School
  •  Molecular pathophysiology of neurodevelopmental disorders associated with mutations in the genes encoding voltage-gated sodium channelsPrincipal Investigator

    • Principal Investigator
      OGIWARA Ikuo
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nippon Medical School
      The Institute of Physical and Chemical Research
  •  Molecular pathology of neurodevelopmental disorders associated with mutations of voltage-gated sodium channel genePrincipal Investigator

    • Principal Investigator
      OGIWARA Ikuo
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Molecular pathology of epilepsy associated with mutations of voltage-gated sodium channel genePrincipal Investigator

    • Principal Investigator
      OGIWARA Ikuo
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Molecular pathology of epilepsy associated with mutations of voltage-gated sodium channel genePrincipal Investigator

    • Principal Investigator
      OGIWARA Ikuo
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Institute of Physical and Chemical Research
  •  ナトリウムチャネル遺伝子変異によって引き起こされるてんかん発病機序の解明Principal Investigator

    • Principal Investigator
      荻原 郁夫
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Investigation of the pathology for epileptic sodium channelopathy

    • Principal Investigator
      YAMAKAWA Kazuhiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      RIKEN

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 Other

All Journal Article Presentation

  • [Journal Article] Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons2021

    • Author(s)
      Yamagata Tetsushi、Ogiwara Ikuo、Tatsukawa Tetsuya、Otsuka Yuka、Mazaki Emi、Inoue Ikuyo、Tokonami Natsuko、Hibi Yurina、Itohara Shigeyoshi、Yamakawa Kazuhiro
    • Journal Title

      bioRxiv

      Volume: 2021 Pages: 437794-437794

    • DOI

      10.1101/2021.03.31.437794

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Journal Article] CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice2020

    • Author(s)
      Yamagata Tetsushi、Raveau Matthieu、Kobayashi Kenta、Miyamoto Hiroyuki、Tatsukawa Tetsuya、Ogiwara Ikuo、Itohara Shigeyoshi、Hensch Takao K.、Yamakawa Kazuhiro
    • Journal Title

      Neurobiology of Disease

      Volume: 141 Pages: 104954-104954

    • DOI

      10.1016/j.nbd.2020.104954

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08284, KAKENHI-PROJECT-18K07577
  • [Journal Article] Involvement of the C‐terminal domain in cell surface localization and G‐protein coupling of mGluR62020

    • Author(s)
      Rai Dilip、Akagi Takumi、Shimohata Atsushi、Ishii Toshiyuki、Gangi Mie、Maruyama Takuma、Wada‐Kiyama Yuko、Ogiwara Ikuo、Kaneda Makoto
    • Journal Title

      Journal of Neurochemistry

      Volume: - Issue: 4 Pages: 837-848

    • DOI

      10.1111/jnc.15217

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08284, KAKENHI-PROJECT-20K09836, KAKENHI-PROJECT-19K09939, KAKENHI-PROJECT-20H03845
  • [Journal Article] Impaired cortico-striatal excitatory transmission triggers epilepsy2019

    • Author(s)
      Miyamoto Hiroyuki、Tatsukawa Tetsuya、Shimohata Atsushi、Yamagata Tetsushi、Suzuki Toshimitsu、Amano Kenji、Mazaki Emi、Raveau Matthieu、Ogiwara Ikuo、Oba-Asaka Atsuko、Hensch Takao K.、Itohara Shigeyoshi、Sakimura Kenji、Kobayashi Kenta、Kobayashi Kazuto、Yamakawa Kazuhiro
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1917-1917

    • DOI

      10.1038/s41467-019-09954-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-18K06535, KAKENHI-PROJECT-18K07577, KAKENHI-PROJECT-19K08284, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02545
  • [Journal Article] Impairments in social novelty recognition and spatial memory in mice with conditional deletion of Scn1a in parvalbumin-expressing cells.2018

    • Author(s)
      Tatsukawa T, Ogiwara I, Mazaki E, Shimohata A, Yamakawa K.
    • Journal Title

      Neurobiology of Disease

      Volume: 112 Pages: 24-34

    • DOI

      10.1016/j.nbd.2018.01.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Journal Article] Dravet syndrome pathophysiology: lessons from mouse models2017

    • Author(s)
      Ogiwara, I.
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation

      Volume: 印刷中

    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Journal Article] Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.2017

    • Author(s)
      Yamagata T, Ogiwara I, Mazaki E, Yanagawa Y, Yamakawa K.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 491 Issue: 4 Pages: 1070-1076

    • DOI

      10.1016/j.bbrc.2017.08.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Journal Article] Generation of transgenic mouse lines that express the green fluorescent protein under the control of the Scn1a promoters.2017

    • Author(s)
      Ogiwara I, Tatsukawa T, Mazaki E, Yamakawa K.
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation

      Volume: 28 Pages: 47-54

    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Journal Article] Dravet syndrome pathophysiology: lessons from mouse models.2017

    • Author(s)
      Ogiwara I.
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation

      Volume: 28 Pages: 11-20

    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Journal Article] Generation of transgenic mouse lines that express the green fluorescent protein under the control of the Scn1a promoters2017

    • Author(s)
      Ogiwara, I., Tatsukawa, T., Mazaki, E., Yamakawa, K.
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation

      Volume: 印刷中

    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Journal Article] Transplantation of medial ganglionic eminence derived GABAergic interneurons in Dravet syndrome model mice2016

    • Author(s)
      Tatsukawa, T., Ogiwara, I., Mazaki, E., Yamakawa, K.
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation

      Volume: 27 Pages: 93-100

    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Journal Article] Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.2014

    • Author(s)
      Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N.
    • Journal Title

      Nat Commun.

      Volume: 5 Issue: 1 Pages: 5525-5525

    • DOI

      10.1038/ncomms6525

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23115101, KAKENHI-PROJECT-24500468, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-24700307, KAKENHI-PROJECT-24770195, KAKENHI-PROJECT-25461572, KAKENHI-PLANNED-26112006, KAKENHI-PROJECT-26860143
  • [Journal Article] Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.2013

    • Author(s)
      Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S, Yamakawa K.
    • Journal Title

      Hum Mol Genet.

      Volume: 22 Issue: 23 Pages: 4784-4804

    • DOI

      10.1093/hmg/ddt331

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22115009, KAKENHI-PROJECT-24621012, KAKENHI-PROJECT-25461572
  • [Journal Article] Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment.2013

    • Author(s)
      Ito S, Ogiwara I, Yamada K, Miyamoto H, Hensch TK, Osawa M, Yamakawa K.
    • Journal Title

      Neurobiology of Disease

      Volume: 49 Pages: 29-40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Journal Article] Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome2013

    • Author(s)
      Auerbach DS, Jones J, Clawson BC, Offord J, Lenk GM, Ogiwara I, Yamakawa K, Meisler MH, Parent JM, Isom LL
    • Journal Title

      PLoS One

      Volume: 8 Issue: 10 Pages: e77843-e77843

    • DOI

      10.1371/journal.pone.0077843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Journal Article] Different degrees of loss of function between GEFS+ and SMEI Na_v1.1 missense mutants at the same residue induced by rescuable folding defects.2012

    • Author(s)
      Sugiura Y, Ogiwara I, Hoshi A, Yamakawa K, Ugawa Y
    • Journal Title

      Epilepsia

      Volume: 53(6)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Journal Article] A homozygous mutation of voltage-gated sodium channel β_I gene SCN1B in a patient with Dravet syndrome.2012

    • Author(s)
      Ogiwara I, Nakayama T, Yamagata T, Ohtani H, Mazaki M, Tsuchiya S, Inoue Y, Yamakawa K
    • Journal Title

      Epilepsia

      Volume: 53(12)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Journal Article] Different degrees of loss of function between GEFS+ and SMEI Nav1.1 missense mutants at the same residue induced by rescuable folding defects.2012

    • Author(s)
      Sugiura, Y., Ogiwara, I., Hoshi, A., Yamakawa, K., Ugawa Y.
    • Journal Title

      Epilepsia

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Journal Article] Efficacy of stiripentol in a mouse model of severe myoclonic epilepsy in infancy.2012

    • Author(s)
      Cao D, Ohtani H, Ogiwara I, Ohtani S, Takahashi Y, Yamakawa K, Inoue Y
    • Journal Title

      Epilepsia

      Volume: 53(7) Pages: 1140-1145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Journal Article] Efficacy of stiripentol in a mouse model of severe myoclonic epilepsy in infancy.2012

    • Author(s)
      Cao, D., Ohtani, H., Ogiwara, I., Ohtani, S., Takahashi, Y., Yamakawa, K., Inoue, Y.
    • Journal Title

      Epilepsia

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Journal Article] A homozygous mutation of voltage-gated sodium channel βI gene SCN1B in a patient with Dravet syndrome.2012

    • Author(s)
      Ogiwara I
    • Journal Title

      Epilepsia

      Volume: 53 Issue: 12

    • DOI

      10.1111/epi.12040

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Journal Article] Analysis of pharmacological effects of 2-deoxy glucose in Scn1a mutant mice.2011

    • Author(s)
      Ogiwara I, Mazaki E, Inoue I, Yamakawa K
    • Journal Title

      Annual Report of the Japan Epilepsy Research Foundation.

      Volume: 22 Pages: 25-30

    • Data Source
      KAKENHI-PROJECT-23791202
  • [Journal Article] Acute encephalopathy in a patient with Dravet syndrome.2011

    • Author(s)
      Tsuji M, Mazaki E, Ogiwara I, Wada T, Iai M, Okumura A, Yamashita S, Yamakawa K, Osaka H
    • Journal Title

      Neuropediatrics

      Volume: 42 Issue: 02 Pages: 78-81

    • DOI

      10.1055/s-0031-1279725

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591264, KAKENHI-PROJECT-23591518, KAKENHI-PROJECT-23791202
  • [Journal Article] Deletions of SCN1A 5' genomic region with promoter activity in Dravet syndrome.2010

    • Author(s)
      Nakayama T, Ogiwara I(共筆頭著者), Ito K, Kaneda M, Mazaki E, Osaka H, Ohtani H, Inoue Y, Fujiwara T, Uematsu M, Haginoya K, Tsuchiya S, Yamakawa K.
    • Journal Title

      Human Mutation 31(7)

      Pages: 820-829

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Journal Article] De novo mutations of voltage-gated sodium channel α_<II> gene SCN2Z in intractable epilepsies2009

    • Author(s)
      Ogiwara, I.
    • Journal Title

      Neurology 73

      Pages: 1046-1053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Journal Article] De novo mutations of voltage-gated sodium channel αII gene SCN2A in intractable epilepsies.2009

    • Author(s)
      Ogiwara I, Ito K, Sawaishi Y, Osaka H, Mazaki E, Inoue I, Montal M, Hashikawa T, Shike T, Fujiwara T, Inoue Y, Kaneda M, Yamakawa K.
    • Journal Title

      Neurology 73(13)

      Pages: 1046-1053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Journal Article] Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying anScn1a gene mutation2007

    • Author(s)
      Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N,. Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa, Y., Obata, K., Furuichi, T., Hensch, T. K., Yamakawa, K
    • Journal Title

      Journal of Neuroscience 27(22)

      Pages: 5903-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Journal Article] Patients with a sodium channel alpha 1 gene mutation show wide phenotypic variation2007

    • Author(s)
      Osaka, H., Ogiwara, I., Mazaki, E., Okamura, N., Yamashita, S., Iai, M., Yamada, M., Kurosawa, K., Iwamoto, H., Yasui-Furukori, N., Kaneko, S., Fujiwara, T., Inoue, Y., Yamakawa, K
    • Journal Title

      Epilepsy Research 75(1)

      Pages: 46-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Journal Article] Navl. 1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scnlagene mntation.2007

    • Author(s)
      Ogiwara, I.
    • Journal Title

      Journal of Neuroscience 27

      Pages: 5903-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Journal Article] A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline2005

    • Author(s)
      Rhodes T.H., Vanoye C.G., Ohmori I., Ogiwara I., Yamakawa K., George A.L.Jr.
    • Journal Title

      Journal of Physiology 569

      Pages: 433-445

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591068
  • [Journal Article] てんかんの責任遺伝子(イオンチャネルを中心に)

    • Author(s)
      荻原郁夫
    • Journal Title

      Medical Science Digest (印刷中)

    • Data Source
      KAKENHI-PROJECT-17790736
  • [Presentation] Intracellular C-terminal domain of mGluR6 is involved in regulating receptor subcellar localization2024

    • Author(s)
      Ogiwara Ikuo, Shimohata Atsushi, Akagi Takumi, Kaneda Makoto
    • Organizer
      第101回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-23K07259
  • [Presentation] Roles of N-linked glycosylation in mGluR6 cell surface delivery and interaction with ELFN12024

    • Author(s)
      Akagi Takumi, Shimohata Atsushi, Takeda Ryota, Sakamoto Tomomi, Ogiwara Ikuo, Kaneda Makoto
    • Organizer
      第101回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-23K07259
  • [Presentation] Analysis of interactions between voltage-gated sodium channel Nav1.1 and fibroblast growth factor homologous factor FGF122023

    • Author(s)
      Ogiwara Ikuo, Yin Chengzhu , Shimohata Atsushi, Gangi Mie, Kaneda Makoto
    • Organizer
      第46回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-23K07259
  • [Presentation] The intracellular C-terminal domain of mGluR6 works as a signal for ER retention2023

    • Author(s)
      Kaneda Makoto, Shimohata Atsushi, Akagi Takumi, Ogiwara Ikuo
    • Organizer
      The 10th Federation of Asian and Oceanian Physiological Societies Congress
    • Data Source
      KAKENHI-PROJECT-23K07259
  • [Presentation] Analysis of interaction between voltage-gated sodium channel Nav1.1 and fibroblast growth factor homologous factor2022

    • Author(s)
      Ogiwara, I., Yin, C., Shimohata, A., Gangi, M., Kaneda, M.
    • Organizer
      第99回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] 代謝型グルタミン酸6型受容体の細胞膜発現におけるC末端領域の役割2021

    • Author(s)
      赤木 巧, Rai Dilip, 下畑 充志, 石井 俊行, 雁木 美衣, 丸山 拓真, 木山 裕子, 荻原 郁夫, 金田 誠
    • Organizer
      第98回日本生理学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] Screening of interacting proteins with voltage-gated sodium channel Nav1.12021

    • Author(s)
      Ogiwara, I.
    • Organizer
      第44回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] 自閉症モデルとしての電位依存性ナトリウムチャネルα2マウスの解析2021

    • Author(s)
      荻原郁夫、立川哲也、眞崎恵美、Maurice Montal、山川 和弘
    • Organizer
      第251回 生理学東京談話会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] Analysis of protein candidates interacting with voltage-gated sodium channel Nav1.12021

    • Author(s)
      Ogiwara, I.
    • Organizer
      第98回日本生理学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] 初代培養網膜双極細胞における代謝型グルタミン酸受容体6型の細胞内局在および膜発現の解析2020

    • Author(s)
      赤木 巧, 下畑 充志, 荻原 郁夫, 金田 誠
    • Organizer
      第43回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] Involvement of the C-terminal domain in cell surface expression and G-protein coupling of mGluR62020

    • Author(s)
      Shimohata A, Rai D, Akagi T, Ishii T, Gangi M, Maruyama T, Kiyama Y, Ogiwara I, Kaneda M.
    • Organizer
      第97回日本生理学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] 代謝型グルタミン酸6型受容体C末端領域と相互作用するタンパク質の探索2020

    • Author(s)
      下畑 充志, 赤木 巧, 荻原 郁夫, 金田 誠
    • Organizer
      第43回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] Identification of proteins that interact with voltage-gated sodium channel Nav1.12020

    • Author(s)
      Ogiwara, I.
    • Organizer
      第43回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] Identification of binding partners of the voltage-gated sodium channel Nav1.12020

    • Author(s)
      Ogiwara I.
    • Organizer
      第97回日本生理学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] Membrane expression of mGluR6 transfected cultured retinal bipolar cells2020

    • Author(s)
      Akagi T, Shimohata A, Ogiwara I, Kaneda M.
    • Organizer
      第97回日本生理学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] Identification of proteins that interact with the voltage-gated sodium channel Nav1.12019

    • Author(s)
      Ogiwara I.
    • Organizer
      第42回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] Impaired excitatory neurotransmission in epilepsy, intellectual disability, autism and schizophrenia caused by sodium channel gene SCN2A mutations2019

    • Author(s)
      Yamakawa K, Miyamoto: H, Tatsukawa T, Yamagata T, Raveau M, Ogiwara I.
    • Organizer
      第42回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] Roles of the C-terminal domain in cell surface expression of mGluR62019

    • Author(s)
      Akagi T, Dilip R, Shimohata A, Ishii T, Gangi M, Maruyama T, Ogiwara I, Kaneda M.
    • Organizer
      第42回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] Altered hippocampal replay underlies memory impairments in SCN2A heterozygous mice2019

    • Author(s)
      Middleton SJ, Kneller EM, Chen S, Ogiwara I, Yamakawa K, McHugh TJ.
    • Organizer
      第42回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] 遺伝子変異マウスを用いたSCN2A遺伝子関連てんかんの発症機序解明2019

    • Author(s)
      荻原 郁夫
    • Organizer
      第7回日本医科大学包括てんかん診療ミーティング(NMS-ENM)学術集会
    • Data Source
      KAKENHI-PROJECT-19K08284
  • [Presentation] 代謝型グルタミン酸受容体6型の極性輸送・膜発現に関わる分子機構の解析2017

    • Author(s)
      赤木巧、レイディリップ、木山裕子、荻原郁夫、金田誠
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県)浜松市
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Presentation] SCN1A遺伝子変異マウスを用いたDravet症候群発症機序解明2017

    • Author(s)
      荻原郁夫
    • Organizer
      てんかん治療研究振興財団第22回研究報告会
    • Place of Presentation
      千里阪急ホテル(大阪府豊中市)
    • Year and Date
      2017-03-03
    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Presentation] Dravet症候群発症機構解明のためのSCN1A遺伝子発現可視化マウスの開発2017

    • Author(s)
      荻原郁夫、立川哲也、真崎恵美、山川和弘
    • Organizer
      てんかん治療研究振興財団第22回研究報告会
    • Place of Presentation
      千里阪急ホテル(大阪府豊中市)
    • Year and Date
      2017-03-03
    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Presentation] Scn1a変異マウスを用いた病態研究(Dravet症候群のモデルとして)2017

    • Author(s)
      荻原郁夫
    • Organizer
      第51回日本てんかん学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Presentation] 電位依存性ナトリウムチャネルNav1.1と相互作用するタンパクの探索2017

    • Author(s)
      荻原郁夫
    • Organizer
      第51回日本てんかん学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K15564
  • [Presentation] 線条体無髄投射神経におけるナトリウムチャネルβ4サブユニットの発現解析2015

    • Author(s)
      宮崎晴子、小山文隆、井上律子、清成寛、紀嘉浩、黒澤大、荻原郁夫、山川和弘、下郡智美、服部信孝、三浦正巳、貫名信行
    • Organizer
      第38回日本神経科学会大会
    • Place of Presentation
      兵庫県神戸市神戸国際会議場
    • Year and Date
      2015-07-29
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] 電位依存性ナトリウムチャネルNav1.2の時空間的発現パターン2015

    • Author(s)
      立川哲也、荻原郁夫、宮本浩行、山形哲司、眞崎恵美、山川和弘
    • Organizer
      第38回日本神経科学会大会
    • Place of Presentation
      兵庫県神戸市神戸国際会議場
    • Year and Date
      2015-07-29
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] パルブアルブミン陽性細胞特異的SCN1A遺伝子破壊マウスに認められた社会的行動異常と空間記憶学習障害2015

    • Author(s)
      荻原郁夫、眞崎恵美、山川和弘
    • Organizer
      第49回日本てんかん学会学術集会
    • Place of Presentation
      長崎県長崎市長崎ブリックホール
    • Year and Date
      2015-10-30
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] Dravet症候群成因解明のためのScn1a遺伝子発現可視化マウスの解析2014

    • Author(s)
      荻原郁夫、眞崎恵美、山川和弘
    • Organizer
      第48回日本てんかん学会学術集会
    • Place of Presentation
      京王プラザホテル(新宿)、東京
    • Year and Date
      2014-10-03
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] 海馬パルブアルブミン抑制性神経細胞におけるNav1.1発現低下がけいれん発作を生じる2014

    • Author(s)
      荻原郁夫、山川和弘
    • Organizer
      第56回日本小児神経学会総会
    • Place of Presentation
      アクトシティ浜松、浜松、静岡
    • Year and Date
      2014-05-30
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] Neuron-type-specific gene deletion reveals a previously unrecognized Nav1.1 distribution in excitatory neurons2014

    • Author(s)
      Ogiwara, I., Iwasato, T., Yamagata, T., Mazaki, E., Yanagawa, Y., Tamamaki, N., Itohara, S., Yamakawa, K.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2014-09-12
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] 電位依存性ナトリウムチャネルα2(Scn2a)遺伝子変異マウスに認められたけいれん感受性の亢進2012

    • Author(s)
      荻原郁夫、中山東城、山川和弘
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2012-05-18
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Selective deletion of the Scn1a gene encoding voltage-gated sodium channel α1 in parvalbumin positive cells in mice triggers epileptic seizures2012

    • Author(s)
      Ogiwara I, Miyamoto H, Mazaki E, Tamamaki N, Hensch TK, Yamakawa K
    • Organizer
      第46回日本てんかん学会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2012-10-11
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Central and obstructive apnea and cardiac arrhythmia during seizures all play roles in sudden death in a Dravet syndrome mouse model2012

    • Author(s)
      Horigome Y, Iizuka M, Ogiwara I, Shinba T, Takahashi Y
    • Organizer
      10^<th> European congress on epileptology.
    • Place of Presentation
      英国London市
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Deletion of a voltage-gated sodium channel αI, Nav1.1, in parvalbumin-positive interneurons confers epileptic seizures in mice2012

    • Author(s)
      Ogiwara I, Miyamoto H, Mazaki E, Tamamaki N, Hensch TK, Yamakawa K
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2012-09-21
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] 高濃度酸素持続吸入による発作時突然死の予防‐Dravet 症候群マウスモデルを用いた検討2012

    • Author(s)
      堀米ゆみ, 榛葉俊一, 飯塚眞喜一, 荻原郁夫, 高橋幸利
    • Organizer
      第46回日本てんかん学会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2012-10-11
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Dravet 症候群モデルマウスに認められた学習障害ならびに自閉症様行動2011

    • Author(s)
      荻原郁夫、伊藤進、山田一之、山川和弘
    • Organizer
      第45回日本てんかん学会
    • Place of Presentation
      新潟県新潟市
    • Year and Date
      2011-10-07
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Deletions of SCN1A 5' genomic region with promoter activity in Dravet syndrome2011

    • Author(s)
      Nakayama T, Ogiwara I, Ito K, Kaneda M, Mazaki E, Osaka H, Ohtani H, Inoue Y, Fujiwara T, Uematsu M, Haginoya K, Tsuchiya S, Yamakawa K
    • Organizer
      2012 American epilepsy society's annual meeting.
    • Place of Presentation
      米国Baltimore市
    • Year and Date
      2011-12-03
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Dravet症候群モデルマウスに認められた学習障害ならびに自閉症様行動2011

    • Author(s)
      荻原郁夫、伊藤進、山田一之、山川和弘
    • Organizer
      第45回日本てんかん学会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Scn1a-GFP BAC transgenic mouse lines showed predominant Nav1.1 expression in parvalbumin-positive interneurons in neocortex and hippocampus2011

    • Author(s)
      Ogiwara I, Mazaki E, Itohara S, Yamakawa K
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] てんかん患者に見出された電位依存性ナトリウムチャネルβ2(SCN2B)遺伝子のミスセンス2011

    • Author(s)
      山形哲司, 真崎恵美, 荻原郁夫, 井上有史, 山川和弘
    • Organizer
      変異第45回日本てんかん学会
    • Place of Presentation
      新潟県新潟市
    • Year and Date
      2011-10-06
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Nav1.1-haploinsufficient mice, a model for Dravet syndrome, exhibit learning impairment and autistic-like behaviors.2011

    • Author(s)
      Ogiwara, I., Ito, S., Yamada, K., Yamakawa, K.
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington, D.C., USA
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Nav1.1-haploinsufficient mice, a model for Dravet syndrome, exhibit learning impairment and autistic-like behaviors2011

    • Author(s)
      Ogiwara I, Ito S, Yamada K, Yamakawa K
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      米国Washington 特別区
    • Year and Date
      2011-11-13
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Scn1a-GFP BAC transgenic mouse lines showed predominant Nav1.1 expression in parvalbumin-positive interneurons in neocortex and hippocampus.2011

    • Author(s)
      Ogiwara, I., Mazaki, E., Itohara, S., Yamakawa, K.
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] 難治てんかんに認められたde novo電位依存性ナトリウムチャネルα2(SCN2A)遺伝子変異2010

    • Author(s)
      荻原郁夫、真崎恵美、井上育代、伊藤公一、金田誠、沢石由記夫、小坂仁、藤原建樹、井上有史、山川和弘
    • Organizer
      第44回日本てんかん学会
    • Place of Presentation
      岡山県岡山市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] 電位依存性ナトリウムチャネルβ1(SCN1B)遺伝子にホモ接合型変異を認めたDravet症候群1症例2010

    • Author(s)
      荻原郁夫
    • Organizer
      第52回日本小児神経学会総会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2010-05-21
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] Scn1a-GFP BAC transgenic mouse lines showed predominant expression of Nav1.1 in parvalbumin-positive interneurons2010

    • Author(s)
      Ogiwara I.
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2010-11-14
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] 電位依存性ナトリウムチャネルα2遺伝子とてんかん2010

    • Author(s)
      荻原郁夫、中山東城、真崎恵美、井上育代、伊藤公一、金田誠、宮本浩行、Takao K. Hensch、沢石由記夫、小坂仁、藤原建樹、井上有史、山川和弘
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      埼玉県大宮市
    • Year and Date
      2010-10-30
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] Scn1a-GFP BAC transgenic mouse lines showed predominant expression of Nav1.1 in parvalbumin-positive interneurons2010

    • Author(s)
      Ogiwara I, Tokonami N, Mazaki E,Inoue I, Yamakawa K.
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      米国San Diego市
    • Year and Date
      2010-11-14
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] Analysis of SCN1A expression using BAC transgenic mice2010

    • Author(s)
      Ogiwara I.
    • Organizer
      2010 Gordon Conference on Mechanisms of Epilepsy and Neuronal Synchronization
    • Place of Presentation
      Waterville, ME, USA
    • Year and Date
      2010-08-11
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] 難治てんかんに認められたde nova電位依存性ナトリウムチャネルα2(SCN2A)遺伝子変異2010

    • Author(s)
      荻原郁夫
    • Organizer
      第44回日本てんかん学会
    • Place of Presentation
      岡山県岡山市
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] Scn1a mice exhibit hyperactivity, autism-like behavioral deficits and learning impairments2010

    • Author(s)
      Ogiwara I, Ito S, Yamada K, Yamakawa K.
    • Organizer
      Neuro 2010
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-09-02
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] Analysis of SCN1A expression using BAC transgenic mice2010

    • Author(s)
      Ogiwara I, Tokonami N, Mazaki E, Yamakawa K.
    • Organizer
      2010 Gordon Conference on Mechanisms of Epilepsy and Neuronal Synchronization
    • Place of Presentation
      米国Waterville市
    • Year and Date
      2010-08-11
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] 電位依存性ナトリウムチャネルβ1(SCN1B)遺伝子にホモ接合型変異を認めたDravet症候群1例2010

    • Author(s)
      荻原郁夫、中山東城、芳村勝城、藤原建樹、井上有史、山川和弘
    • Organizer
      第52回日本小児神経学会総会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2010-05-21
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] Analysis of alternative promoters of voltage-gated Na^+ channelα_I gene2009

    • Author(s)
      Ogiwara I, Ito K, Mazaki E, Kaneda M, Yamakawa K.
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      米国Chicago市
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] Analysis of alternative promoters of voltage-gated Na^+ channel α_I gene2009

    • Author(s)
      荻原郁夫
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      米国 Chicago 市
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] 難治性乳幼児てんかんに認められたde novo電位依存性ナトリウムチャネルα2遺伝子変異2009

    • Author(s)
      荻原郁夫、沢石由記夫、小坂仁、藤原建樹、井上有史、山川和弘
    • Organizer
      第51回日本小児神経学会総会
    • Place of Presentation
      鳥取県米子市
    • Year and Date
      2009-05-29
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] マウス小脳プルキンエ細胞における電位依存性ナトリウムチャネルα1遺伝子の発現解析2009

    • Author(s)
      荻原郁夫、伊藤公一、真崎恵美、金田誠、山川和弘
    • Organizer
      日本人類遺伝学会第54回大会
    • Place of Presentation
      東京都港区
    • Year and Date
      2009-09-24
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] 難治性乳幼児てんかんに認められた de novo 電位依存性ナトリウムチャネルα2遺伝子変異2009

    • Author(s)
      荻原郁夫
    • Organizer
      第51回日本小児神経学会総会
    • Place of Presentation
      鳥取県米子市
    • Year and Date
      2009-05-29
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] Analysis of voltage-gated sodium channel α1 expression using BAC transgenic mice2009

    • Author(s)
      荻原郁夫
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2009-09-18
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] Analysis of voltage-gated sodium channelα1 expression using BAC transgenic mice2009

    • Author(s)
      Ogiwara I, Mazaki E, Itohara S, Yamakawa K.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2009-09-18
    • Data Source
      KAKENHI-PROJECT-21791020
  • [Presentation] Mutation analysis of the voltage-gated sodium channel alpha II gene in patients with early childhood intractable epilepsies2008

    • Author(s)
      Ogiwara, I., Ito, K., Osaka, H., Mazaki, E., Inoue, I., Fujiwara, T., Inoue, Y., Kaneda, M., Yamakawa,K.
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington, D.C
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] Voltage-gated Na+ channel α1 gene is transcribed from two widely separated promoters2008

    • Author(s)
      荻原郁夫,伊藤公一,真崎恵美,金田誠,山川和弘
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] 電位依存性ナトリウムチャネルα2遺伝子変異を認めた点頭てんかん1症例2008

    • Author(s)
      荻原郁夫、伊藤公一、真崎恵美、井上育代、四家達彦、藤原建樹、井上有史、金田誠、山川和弘
    • Organizer
      第42回日本てんかん学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] 難治性乳幼児てんかんに認められた電位依存性ナトリウムチャネルα2遺伝子変異電位2008

    • Author(s)
      荻原郁夫、伊藤公一、小坂仁、真崎恵美、井上育代、四家達彦、藤原建樹、井上有史、金田誠、山川和弘
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] 電位依存性ナトリウムチャネルα1(SCN1A)遺伝子変異とてんかん2008

    • Author(s)
      荻原郁夫、山川和弘
    • Organizer
      第50回日本小児神経学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] Navl. 1 predominantly localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in Navl. 1-deficient mice2007

    • Author(s)
      Ogiwara, I.
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] Nav1.1 predominantly localizes to axons in the developing mouse brain2007

    • Author(s)
      Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Itohara, S., Yanagawa, Y., Obata, K., Furuichi, T., Hensch, T.K., Yamakawa, K.
    • Organizer
      Neuroscience 2007
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] Epileptic seizures in mice carrying a premature stop codon in the voltage-gated sodium channel alpha 1 gene: a model for human severe myoclonic epilepsy in infancy2007

    • Author(s)
      Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa, Y., Obata, K., Furuichi, T., Hensch, T. K., Yamakawa, K
    • Organizer
      第30回日本神経科学大会サテライトシンポジウム
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] Nav1.1 predominantly localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in Nav1.1-deficient mice2007

    • Author(s)
      荻原郁夫,宮本浩行,森田規之,アタポアナフィセ,真崎恵美,井上育代,柳川右千夫,小幡邦彦,ヘンシュ K. 貴雄,古市貞一,山川和弘
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] 乳児重症ミオクロニーてんかんモデルマウスにおける大脳皮質抑制性神経細胞の異常2007

    • Author(s)
      荻原郁夫,森田規之,アタポアナフィセ,宮本浩行,井上育代,真崎恵美,柳川右千夫,小幡邦彦,ヘンシュ貴雄,古市貞一,山川和弘
    • Organizer
      第41回日本てんかん学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] Navl. 1 predominantly localizes to axons in the developing mouse brain2007

    • Author(s)
      Ogiwara, I.
    • Organizer
      Neuroscience 2007
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] てんかんと電位依存性ナトリウムチャネル遺伝子変異2007

    • Author(s)
      荻原郁夫、真崎恵美、井上育代、森本昌史、小坂仁、萩野谷和裕、井上有史、藤原建樹、山川和弘
    • Organizer
      日本人類遺伝学会第52回大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19790747
  • [Presentation] 電位依存性ナトリウムチャネルα2(Scn2a)遺伝子変異マウスに認められたけいれん感受性の亢進

    • Author(s)
      荻原郁夫
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      北海道札幌市
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] Nav1.1 haploinsufficient excitatory and inhibitory neurons play distinct roles in the epileptic pathology in Dravet syndrome model mice

    • Author(s)
      Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S, Yamakawa
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center, San Diego, CA, USA
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] Heart rate variability analysis reveals altered autonomic tone in a mouse model of Dravet syndrome

    • Author(s)
      Auerbach DS, Clawson BC, Ogiwara I, Yamakawa K, Meisler MH, Parent JM, Isom LL
    • Organizer
      American Epilepsy Society 67th annual meeting
    • Place of Presentation
      Walter E. Washington Convention Center, Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] 抑制性神経細胞のNav1.1ハプロ不全がてんかんの原因で、興奮性神経細胞のNav1.1ハプロ不全は症状を軽減する

    • Author(s)
      荻原郁夫、岩里琢治、宮本浩行、岩田亮平、山形哲司、眞崎恵美、柳川右千夫、玉巻伸章、ヘンシュ貴雄、糸原重美、山川和弘
    • Organizer
      第47回日本てんかん学会学術集会
    • Place of Presentation
      福岡県北九州市北九州国際会議場
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] Selective deletion of the Scn1a gene encoding voltage-gated sodium channel α1 in parvalbumin positive cells in mice triggers epileptic seizures.

    • Author(s)
      Ogiwara I
    • Organizer
      第46回日本てんかん学会
    • Place of Presentation
      東京都千代田区
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] パルブアルブミン陽性細胞を標的としたScn1a遺伝子破壊はマウスにてんかん発作と運動失調を引き起こす

    • Author(s)
      荻原郁夫、山川和弘
    • Organizer
      第55回日本小児神経学会総会
    • Place of Presentation
      大分県大分市iichiko総合文化センター
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] Deletion of a voltage-gated sodium channel αI, Nav1.1, in parvalbumin-positive interneurons confers epileptic seizures in mice.

    • Author(s)
      Ogiwara I
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      愛知県名古屋市
    • Data Source
      KAKENHI-PROJECT-23791202
  • [Presentation] SCN1A遺伝子の抑制性細胞特異的ノックアウトは高致死性てんかんを生じるが、興奮性細胞特異的ノックアウトで生存率が上昇する

    • Author(s)
      荻原郁夫、岩里琢治、宮本浩行、岩田亮平、山形哲司、眞崎恵美、柳川右千夫、玉巻伸章、ヘンシュ貴雄、糸原重美、山川和弘
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      宮城県仙台市江陽グランドホテル
    • Data Source
      KAKENHI-PROJECT-25461572
  • [Presentation] Nav1.1 haploinsufficient excitatory and inhibitory neurons play distinct roles in epilepsy

    • Author(s)
      Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S, Yamakawa K
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都府京都市国立京都国際会館
    • Data Source
      KAKENHI-PROJECT-25461572
  • 1.  Hirose Shinichi (60248515)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  YAMAKAWA Kazuhiro (30241235)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  KANEDA Makoto (30214480)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  ISHII Toshiyuki (10643140)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  AKAGI Takumi (50192878)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  石井 敦士 (90568825)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  桂林 秀太郎 (50435145)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  田中 泰圭 (50714466)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  道具 伸也 (60399186)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  MAZAKI Emi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 11.  USUI Sumiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Suzuki Chiaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  岩里 琢治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  宮崎 晴子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  貫名 信行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  小坂 仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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