Ogiwara Ikuo 荻原郁夫

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OGIWARA Ikuo 荻原郁夫

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Researcher Number	30373286
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 日本医科大学, 医学部, 准教授 2015 – 2017: 日本医科大学, 医学部, 准教授 2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 副チームリーダー 2013: 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 2008 – 2012: The Institute of Physical and Chemical Research, 神経遺伝研究チーム, 研究員 2007: The Institute of Physical and Chemical Research, 神経遺伝研究チーム, 研究員 2004 – 2006: 独立行政法人理化学研究所, 神経遺伝研究チーム, 研究員
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Psychiatric science Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Keywords	Principal Investigator てんかん / 脳・神経 / 電位依存性ナトリウムチャネル / 神経科学 / ナトリウムチャネル遺伝子 / 脳神経疾患 / 興奮性神経細胞 / てんかん性脳症 / 抑制性神経細胞 / 疾患プロテオーム … More / 自閉症 / タンパク複合体 / タンパク質複合体 / ナトリウムチャネル / 自閉症スペクトラム障害 / 知的障害 / トランスレーショナルリサーチ / 精神発達障害 / インターニューロン … More Except Principal Investigator てんかん / GEFS+ / SMEI / SCN2A / 神経作動薬 / 根治薬 / チャネル / けいれん / ハイスループットスクリーニング / 創薬 / ハイスルーブットスクリーニング / 遺伝子改変動物 / iPS細胞 / Patch-clamp analysis / Nonsense mutation / Genes / Sodium channel / Epilepsy / GEFS_+ / パッチクランプ法 / ナンセンス変異 / 遺伝子 / ナトリウムチャネル Less

Establishment of a practical pipeline to develop drugs for intractable epilepsies based on their uncovered molecular pathomechanisms
- Principal Investigator
  
  廣瀬伸一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Fukuoka University
Protein-protein interactions as potential therapeutic targets for epileptic encephalopathyPrincipal Investigator
- Principal Investigator
  
  荻原郁夫
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nippon Medical School
Fundamental Research for an Innovative Drug Discovery Based on the Molecular Pathomechanisms of Refractory Epilepsy Using a Multidimensional Approach.
- Principal Investigator
  
  Hirose Shinichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Fukuoka University
Proteins interacting with Nav1.1 may be potential therapeutic targets for epilepsyPrincipal Investigator
- Principal Investigator
  
  Ogiwara Ikuo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nippon Medical School
Analysis of interacting-partners of Nav1.1 in premature mouse brainPrincipal Investigator
- Principal Investigator
  
  OGIWARA Ikuo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Nippon Medical School
Molecular pathophysiology of neurodevelopmental disorders associated with mutations in the genes encoding voltage-gated sodium channelsPrincipal Investigator
- Principal Investigator
  
  OGIWARA Ikuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nippon Medical School
  The Institute of Physical and Chemical Research
Molecular pathology of neurodevelopmental disorders associated with mutations of voltage-gated sodium channel genePrincipal Investigator
- Principal Investigator
  
  OGIWARA Ikuo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Institute of Physical and Chemical Research
Molecular pathology of epilepsy associated with mutations of voltage-gated sodium channel genePrincipal Investigator
- Principal Investigator
  
  OGIWARA Ikuo
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Institute of Physical and Chemical Research
Molecular pathology of epilepsy associated with mutations of voltage-gated sodium channel genePrincipal Investigator
- Principal Investigator
  
  OGIWARA Ikuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Institute of Physical and Chemical Research
ナトリウムチャネル遺伝子変異によって引き起こされるてんかん発病機序の解明Principal Investigator
- Principal Investigator
  
  荻原郁夫
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Institute of Physical and Chemical Research
Investigation of the pathology for epileptic sodium channelopathy
- Principal Investigator
  
  YAMAKAWA Kazuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  RIKEN

[Journal Article] Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons2021
- Author(s)
  Yamagata Tetsushi、Ogiwara Ikuo、Tatsukawa Tetsuya、Otsuka Yuka、Mazaki Emi、Inoue Ikuyo、Tokonami Natsuko、Hibi Yurina、Itohara Shigeyoshi、Yamakawa Kazuhiro
- Journal Title
  
  bioRxiv
  
  Volume: 2021 Pages: 437794-437794
- DOI
  10.1101/2021.03.31.437794
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08284
[Journal Article] CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice2020
- Author(s)
  Yamagata Tetsushi、Raveau Matthieu、Kobayashi Kenta、Miyamoto Hiroyuki、Tatsukawa Tetsuya、Ogiwara Ikuo、Itohara Shigeyoshi、Hensch Takao K.、Yamakawa Kazuhiro
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 141 Pages: 104954-104954
- DOI
  10.1016/j.nbd.2020.104954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08284, KAKENHI-PROJECT-18K07577
[Journal Article] Involvement of the C‐terminal domain in cell surface localization and G‐protein coupling of mGluR62020
- Author(s)
  Rai Dilip、Akagi Takumi、Shimohata Atsushi、Ishii Toshiyuki、Gangi Mie、Maruyama Takuma、Wada‐Kiyama Yuko、Ogiwara Ikuo、Kaneda Makoto
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: － Issue: 4 Pages: 837-848
- DOI
  10.1111/jnc.15217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08284, KAKENHI-PROJECT-20K09836, KAKENHI-PROJECT-19K09939, KAKENHI-PROJECT-20H03845
[Journal Article] Impaired cortico-striatal excitatory transmission triggers epilepsy2019
- Author(s)
  Miyamoto Hiroyuki、Tatsukawa Tetsuya、Shimohata Atsushi、Yamagata Tetsushi、Suzuki Toshimitsu、Amano Kenji、Mazaki Emi、Raveau Matthieu、Ogiwara Ikuo、Oba-Asaka Atsuko、Hensch Takao K.、Itohara Shigeyoshi、Sakimura Kenji、Kobayashi Kenta、Kobayashi Kazuto、Yamakawa Kazuhiro
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1917-1917
- DOI
  10.1038/s41467-019-09954-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-18K06535, KAKENHI-PROJECT-18K07577, KAKENHI-PROJECT-19K08284, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02545
[Journal Article] Impairments in social novelty recognition and spatial memory in mice with conditional deletion of Scn1a in parvalbumin-expressing cells.2018
- Author(s)
  Tatsukawa T, Ogiwara I, Mazaki E, Shimohata A, Yamakawa K.
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 112 Pages: 24-34
- DOI
  10.1016/j.nbd.2018.01.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15564
[Journal Article] Dravet syndrome pathophysiology: lessons from mouse models2017
- Author(s)
  Ogiwara, I.
- Journal Title
  
  Annual Report of the Japan Epilepsy Research Foundation
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-16K15564
[Journal Article] Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.2017
- Author(s)
  Yamagata T, Ogiwara I, Mazaki E, Yanagawa Y, Yamakawa K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 491 Issue: 4 Pages: 1070-1076
- DOI
  10.1016/j.bbrc.2017.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15564
[Journal Article] Generation of transgenic mouse lines that express the green fluorescent protein under the control of the Scn1a promoters.2017
- Author(s)
  Ogiwara I, Tatsukawa T, Mazaki E, Yamakawa K.
- Journal Title
  
  Annual Report of the Japan Epilepsy Research Foundation
  
  Volume: 28 Pages: 47-54
- Data Source
  KAKENHI-PROJECT-16K15564
[Journal Article] Dravet syndrome pathophysiology: lessons from mouse models.2017
- Author(s)
  Ogiwara I.
- Journal Title
  
  Annual Report of the Japan Epilepsy Research Foundation
  
  Volume: 28 Pages: 11-20
- Data Source
  KAKENHI-PROJECT-16K15564
[Journal Article] Generation of transgenic mouse lines that express the green fluorescent protein under the control of the Scn1a promoters2017
- Author(s)
  Ogiwara, I., Tatsukawa, T., Mazaki, E., Yamakawa, K.
- Journal Title
  
  Annual Report of the Japan Epilepsy Research Foundation
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-16K15564
[Journal Article] Transplantation of medial ganglionic eminence derived GABAergic interneurons in Dravet syndrome model mice2016
- Author(s)
  Tatsukawa, T., Ogiwara, I., Mazaki, E., Yamakawa, K.
- Journal Title
  
  Annual Report of the Japan Epilepsy Research Foundation
  
  Volume: 27 Pages: 93-100
- Data Source
  KAKENHI-PROJECT-16K15564
[Journal Article] Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.2014
- Author(s)
  Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N.
- Journal Title
  
  Nat Commun.
  
  Volume: 5 Issue: 1 Pages: 5525-5525
- DOI
  10.1038/ncomms6525
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23115101, KAKENHI-PROJECT-24500468, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-24700307, KAKENHI-PROJECT-24770195, KAKENHI-PROJECT-25461572, KAKENHI-PLANNED-26112006, KAKENHI-PROJECT-26860143
[Journal Article] Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.2013
- Author(s)
  Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S, Yamakawa K.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 22 Issue: 23 Pages: 4784-4804
- DOI
  10.1093/hmg/ddt331
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22115009, KAKENHI-PROJECT-24621012, KAKENHI-PROJECT-25461572
[Journal Article] Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment.2013
- Author(s)
  Ito S, Ogiwara I, Yamada K, Miyamoto H, Hensch TK, Osawa M, Yamakawa K.
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 49 Pages: 29-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791202
[Journal Article] Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome2013
- Author(s)
  Auerbach DS, Jones J, Clawson BC, Offord J, Lenk GM, Ogiwara I, Yamakawa K, Meisler MH, Parent JM, Isom LL
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 10 Pages: e77843-e77843
- DOI
  10.1371/journal.pone.0077843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461572
[Journal Article] Different degrees of loss of function between GEFS+ and SMEI Na_v1.1 missense mutants at the same residue induced by rescuable folding defects.2012
- Author(s)
  Sugiura Y, Ogiwara I, Hoshi A, Yamakawa K, Ugawa Y
- Journal Title
  
  Epilepsia
  
  Volume: 53(6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791202
[Journal Article] A homozygous mutation of voltage-gated sodium channel β_I gene SCN1B in a patient with Dravet syndrome.2012
- Author(s)
  Ogiwara I, Nakayama T, Yamagata T, Ohtani H, Mazaki M, Tsuchiya S, Inoue Y, Yamakawa K
- Journal Title
  
  Epilepsia
  
  Volume: 53(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791202
[Journal Article] Different degrees of loss of function between GEFS+ and SMEI Nav1.1 missense mutants at the same residue induced by rescuable folding defects.2012
- Author(s)
  Sugiura, Y., Ogiwara, I., Hoshi, A., Yamakawa, K., Ugawa Y.
- Journal Title
  
  Epilepsia
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791202
[Journal Article] Efficacy of stiripentol in a mouse model of severe myoclonic epilepsy in infancy.2012
- Author(s)
  Cao D, Ohtani H, Ogiwara I, Ohtani S, Takahashi Y, Yamakawa K, Inoue Y
- Journal Title
  
  Epilepsia
  
  Volume: 53(7) Pages: 1140-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791202
[Journal Article] Efficacy of stiripentol in a mouse model of severe myoclonic epilepsy in infancy.2012
- Author(s)
  Cao, D., Ohtani, H., Ogiwara, I., Ohtani, S., Takahashi, Y., Yamakawa, K., Inoue, Y.
- Journal Title
  
  Epilepsia
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791202
[Journal Article] A homozygous mutation of voltage-gated sodium channel βI gene SCN1B in a patient with Dravet syndrome.2012
- Author(s)
  Ogiwara I
- Journal Title
  
  Epilepsia
  
  Volume: 53 Issue: 12
- DOI
  10.1111/epi.12040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791202
[Journal Article] Analysis of pharmacological effects of 2-deoxy glucose in Scn1a mutant mice.2011
- Author(s)
  Ogiwara I, Mazaki E, Inoue I, Yamakawa K
- Journal Title
  
  Annual Report of the Japan Epilepsy Research Foundation.
  
  Volume: 22 Pages: 25-30
- Data Source
  KAKENHI-PROJECT-23791202
[Journal Article] Acute encephalopathy in a patient with Dravet syndrome.2011
- Author(s)
  Tsuji M, Mazaki E, Ogiwara I, Wada T, Iai M, Okumura A, Yamashita S, Yamakawa K, Osaka H
- Journal Title
  
  Neuropediatrics
  
  Volume: 42 Issue: 02 Pages: 78-81
- DOI
  10.1055/s-0031-1279725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591264, KAKENHI-PROJECT-23591518, KAKENHI-PROJECT-23791202
[Journal Article] Deletions of SCN1A 5' genomic region with promoter activity in Dravet syndrome.2010
- Author(s)
  Nakayama T, Ogiwara I(共筆頭著者), Ito K, Kaneda M, Mazaki E, Osaka H, Ohtani H, Inoue Y, Fujiwara T, Uematsu M, Haginoya K, Tsuchiya S, Yamakawa K.
- Journal Title
  
  Human Mutation 31(7)
  
  Pages: 820-829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791020
[Journal Article] De novo mutations of voltage-gated sodium channel α_<II> gene SCN2Z in intractable epilepsies2009
- Author(s)
  Ogiwara, I.
- Journal Title
  
  Neurology 73
  
  Pages: 1046-1053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791020
[Journal Article] De novo mutations of voltage-gated sodium channel αII gene SCN2A in intractable epilepsies.2009
- Author(s)
  Ogiwara I, Ito K, Sawaishi Y, Osaka H, Mazaki E, Inoue I, Montal M, Hashikawa T, Shike T, Fujiwara T, Inoue Y, Kaneda M, Yamakawa K.
- Journal Title
  
  Neurology 73(13)
  
  Pages: 1046-1053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791020
[Journal Article] Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying anScn1a gene mutation2007
- Author(s)
  Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N,. Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa, Y., Obata, K., Furuichi, T., Hensch, T. K., Yamakawa, K
- Journal Title
  
  Journal of Neuroscience 27(22)
  
  Pages: 5903-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790747
[Journal Article] Patients with a sodium channel alpha 1 gene mutation show wide phenotypic variation2007
- Author(s)
  Osaka, H., Ogiwara, I., Mazaki, E., Okamura, N., Yamashita, S., Iai, M., Yamada, M., Kurosawa, K., Iwamoto, H., Yasui-Furukori, N., Kaneko, S., Fujiwara, T., Inoue, Y., Yamakawa, K
- Journal Title
  
  Epilepsy Research 75(1)
  
  Pages: 46-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790747
[Journal Article] Navl. 1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scnlagene mntation.2007
- Author(s)
  Ogiwara, I.
- Journal Title
  
  Journal of Neuroscience 27
  
  Pages: 5903-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790747
[Journal Article] A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline2005
- Author(s)
  Rhodes T.H., Vanoye C.G., Ohmori I., Ogiwara I., Yamakawa K., George A.L.Jr.
- Journal Title
  
  Journal of Physiology 569
  
  Pages: 433-445
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591068
[Journal Article] てんかんの責任遺伝子(イオンチャネルを中心に)
- Author(s)
  荻原郁夫
- Journal Title
  
  Medical Science Digest (印刷中)
- Data Source
  KAKENHI-PROJECT-17790736
[Presentation] Intracellular C-terminal domain of mGluR6 is involved in regulating receptor subcellar localization2024
- Author(s)
  Ogiwara Ikuo, Shimohata Atsushi, Akagi Takumi, Kaneda Makoto
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K07259
[Presentation] Roles of N-linked glycosylation in mGluR6 cell surface delivery and interaction with ELFN12024
- Author(s)
  Akagi Takumi, Shimohata Atsushi, Takeda Ryota, Sakamoto Tomomi, Ogiwara Ikuo, Kaneda Makoto
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K07259
[Presentation] Analysis of interactions between voltage-gated sodium channel Nav1.1 and fibroblast growth factor homologous factor FGF122023
- Author(s)
  Ogiwara Ikuo, Yin Chengzhu , Shimohata Atsushi, Gangi Mie, Kaneda Makoto
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K07259
[Presentation] The intracellular C-terminal domain of mGluR6 works as a signal for ER retention2023
- Author(s)
  Kaneda Makoto, Shimohata Atsushi, Akagi Takumi, Ogiwara Ikuo
- Organizer
  The 10th Federation of Asian and Oceanian Physiological Societies Congress
- Data Source
  KAKENHI-PROJECT-23K07259
[Presentation] Analysis of interaction between voltage-gated sodium channel Nav1.1 and fibroblast growth factor homologous factor2022
- Author(s)
  Ogiwara, I., Yin, C., Shimohata, A., Gangi, M., Kaneda, M.
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] 代謝型グルタミン酸6型受容体の細胞膜発現におけるC末端領域の役割2021
- Author(s)
  赤木巧, Rai Dilip, 下畑充志, 石井俊行, 雁木美衣, 丸山拓真, 木山裕子, 荻原郁夫, 金田誠
- Organizer
  第98回日本生理学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] Screening of interacting proteins with voltage-gated sodium channel Nav1.12021
- Author(s)
  Ogiwara, I.
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] 自閉症モデルとしての電位依存性ナトリウムチャネルα２マウスの解析2021
- Author(s)
  荻原郁夫、立川哲也、眞崎恵美、Maurice Montal、山川　和弘
- Organizer
  第251回生理学東京談話会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] Analysis of protein candidates interacting with voltage-gated sodium channel Nav1.12021
- Author(s)
  Ogiwara, I.
- Organizer
  第98回日本生理学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] 初代培養網膜双極細胞における代謝型グルタミン酸受容体6型の細胞内局在および膜発現の解析2020
- Author(s)
  赤木巧, 下畑充志, 荻原郁夫, 金田誠
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] Involvement of the C-terminal domain in cell surface expression and G-protein coupling of mGluR62020
- Author(s)
  Shimohata A, Rai D, Akagi T, Ishii T, Gangi M, Maruyama T, Kiyama Y, Ogiwara I, Kaneda M.
- Organizer
  第97回日本生理学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] 代謝型グルタミン酸6型受容体C末端領域と相互作用するタンパク質の探索2020
- Author(s)
  下畑充志, 赤木巧, 荻原郁夫, 金田誠
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] Identification of proteins that interact with voltage-gated sodium channel Nav1.12020
- Author(s)
  Ogiwara, I.
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] Identification of binding partners of the voltage-gated sodium channel Nav1.12020
- Author(s)
  Ogiwara I.
- Organizer
  第97回日本生理学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] Membrane expression of mGluR6 transfected cultured retinal bipolar cells2020
- Author(s)
  Akagi T, Shimohata A, Ogiwara I, Kaneda M.
- Organizer
  第97回日本生理学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] Identification of proteins that interact with the voltage-gated sodium channel Nav1.12019
- Author(s)
  Ogiwara I.
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] Impaired excitatory neurotransmission in epilepsy, intellectual disability, autism and schizophrenia caused by sodium channel gene SCN2A mutations2019
- Author(s)
  Yamakawa K, Miyamoto: H, Tatsukawa T, Yamagata T, Raveau M, Ogiwara I.
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] Roles of the C-terminal domain in cell surface expression of mGluR62019
- Author(s)
  Akagi T, Dilip R, Shimohata A, Ishii T, Gangi M, Maruyama T, Ogiwara I, Kaneda M.
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] Altered hippocampal replay underlies memory impairments in SCN2A heterozygous mice2019
- Author(s)
  Middleton SJ, Kneller EM, Chen S, Ogiwara I, Yamakawa K, McHugh TJ.
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] 遺伝子変異マウスを用いたSCN2A遺伝子関連てんかんの発症機序解明2019
- Author(s)
  荻原　郁夫
- Organizer
  第7回日本医科大学包括てんかん診療ミーティング（NMS-ENM）学術集会
- Data Source
  KAKENHI-PROJECT-19K08284
[Presentation] 代謝型グルタミン酸受容体6型の極性輸送・膜発現に関わる分子機構の解析2017
- Author(s)
  赤木巧、レイディリップ、木山裕子、荻原郁夫、金田誠
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松（静岡県）浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K15564
[Presentation] SCN1A遺伝子変異マウスを用いたDravet症候群発症機序解明2017
- Author(s)
  荻原郁夫
- Organizer
  てんかん治療研究振興財団第22回研究報告会
- Place of Presentation
  千里阪急ホテル（大阪府豊中市）
- Year and Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16K15564
[Presentation] Dravet症候群発症機構解明のためのSCN1A遺伝子発現可視化マウスの開発2017
- Author(s)
  荻原郁夫、立川哲也、真崎恵美、山川和弘
- Organizer
  てんかん治療研究振興財団第22回研究報告会
- Place of Presentation
  千里阪急ホテル（大阪府豊中市）
- Year and Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16K15564
[Presentation] Scn1a変異マウスを用いた病態研究（Dravet症候群のモデルとして）2017
- Author(s)
  荻原郁夫
- Organizer
  第51回日本てんかん学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15564
[Presentation] 電位依存性ナトリウムチャネルNav1.1と相互作用するタンパクの探索2017
- Author(s)
  荻原郁夫
- Organizer
  第51回日本てんかん学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15564
[Presentation] 線条体無髄投射神経におけるナトリウムチャネルβ4サブユニットの発現解析2015
- Author(s)
  宮崎晴子、小山文隆、井上律子、清成寛、紀嘉浩、黒澤大、荻原郁夫、山川和弘、下郡智美、服部信孝、三浦正巳、貫名信行
- Organizer
  第38回日本神経科学会大会
- Place of Presentation
  兵庫県神戸市神戸国際会議場
- Year and Date
  2015-07-29
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] 電位依存性ナトリウムチャネルNav1.2の時空間的発現パターン2015
- Author(s)
  立川哲也、荻原郁夫、宮本浩行、山形哲司、眞崎恵美、山川和弘
- Organizer
  第38回日本神経科学会大会
- Place of Presentation
  兵庫県神戸市神戸国際会議場
- Year and Date
  2015-07-29
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] パルブアルブミン陽性細胞特異的SCN1A遺伝子破壊マウスに認められた社会的行動異常と空間記憶学習障害2015
- Author(s)
  荻原郁夫、眞崎恵美、山川和弘
- Organizer
  第49回日本てんかん学会学術集会
- Place of Presentation
  長崎県長崎市長崎ブリックホール
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] Dravet症候群成因解明のためのScn1a遺伝子発現可視化マウスの解析2014
- Author(s)
  荻原郁夫、眞崎恵美、山川和弘
- Organizer
  第48回日本てんかん学会学術集会
- Place of Presentation
  京王プラザホテル（新宿）、東京
- Year and Date
  2014-10-03
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] 海馬パルブアルブミン抑制性神経細胞におけるNav1.1発現低下がけいれん発作を生じる2014
- Author(s)
  荻原郁夫、山川和弘
- Organizer
  第56回日本小児神経学会総会
- Place of Presentation
  アクトシティ浜松、浜松、静岡
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] Neuron-type-specific gene deletion reveals a previously unrecognized Nav1.1 distribution in excitatory neurons2014
- Author(s)
  Ogiwara, I., Iwasato, T., Yamagata, T., Mazaki, E., Yanagawa, Y., Tamamaki, N., Itohara, S., Yamakawa, K.
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] 電位依存性ナトリウムチャネルα2(Scn2a)遺伝子変異マウスに認められたけいれん感受性の亢進2012
- Author(s)
  荻原郁夫、中山東城、山川和弘
- Organizer
  第54回日本小児神経学会総会
- Place of Presentation
  北海道札幌市
- Year and Date
  2012-05-18
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Selective deletion of the Scn1a gene encoding voltage-gated sodium channel α1 in parvalbumin positive cells in mice triggers epileptic seizures2012
- Author(s)
  Ogiwara I, Miyamoto H, Mazaki E, Tamamaki N, Hensch TK, Yamakawa K
- Organizer
  第46回日本てんかん学会
- Place of Presentation
  東京都千代田区
- Year and Date
  2012-10-11
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Central and obstructive apnea and cardiac arrhythmia during seizures all play roles in sudden death in a Dravet syndrome mouse model2012
- Author(s)
  Horigome Y, Iizuka M, Ogiwara I, Shinba T, Takahashi Y
- Organizer
  10^<th> European congress on epileptology.
- Place of Presentation
  英国London市
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Deletion of a voltage-gated sodium channel αI, Nav1.1, in parvalbumin-positive interneurons confers epileptic seizures in mice2012
- Author(s)
  Ogiwara I, Miyamoto H, Mazaki E, Tamamaki N, Hensch TK, Yamakawa K
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] 高濃度酸素持続吸入による発作時突然死の予防‐Dravet 症候群マウスモデルを用いた検討2012
- Author(s)
  堀米ゆみ, 榛葉俊一, 飯塚眞喜一, 荻原郁夫, 高橋幸利
- Organizer
  第46回日本てんかん学会
- Place of Presentation
  東京都千代田区
- Year and Date
  2012-10-11
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Dravet 症候群モデルマウスに認められた学習障害ならびに自閉症様行動2011
- Author(s)
  荻原郁夫、伊藤進、山田一之、山川和弘
- Organizer
  第45回日本てんかん学会
- Place of Presentation
  新潟県新潟市
- Year and Date
  2011-10-07
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Deletions of SCN1A 5' genomic region with promoter activity in Dravet syndrome2011
- Author(s)
  Nakayama T, Ogiwara I, Ito K, Kaneda M, Mazaki E, Osaka H, Ohtani H, Inoue Y, Fujiwara T, Uematsu M, Haginoya K, Tsuchiya S, Yamakawa K
- Organizer
  2012 American epilepsy society's annual meeting.
- Place of Presentation
  米国Baltimore市
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Dravet症候群モデルマウスに認められた学習障害ならびに自閉症様行動2011
- Author(s)
  荻原郁夫、伊藤進、山田一之、山川和弘
- Organizer
  第45回日本てんかん学会
- Place of Presentation
  朱鷺メッセ（新潟）
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Scn1a-GFP BAC transgenic mouse lines showed predominant Nav1.1 expression in parvalbumin-positive interneurons in neocortex and hippocampus2011
- Author(s)
  Ogiwara I, Mazaki E, Itohara S, Yamakawa K
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] てんかん患者に見出された電位依存性ナトリウムチャネルβ2(SCN2B)遺伝子のミスセンス2011
- Author(s)
  山形哲司, 真崎恵美, 荻原郁夫, 井上有史, 山川和弘
- Organizer
  変異第45回日本てんかん学会
- Place of Presentation
  新潟県新潟市
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Nav1.1-haploinsufficient mice, a model for Dravet syndrome, exhibit learning impairment and autistic-like behaviors.2011
- Author(s)
  Ogiwara, I., Ito, S., Yamada, K., Yamakawa, K.
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington, D.C., USA
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Nav1.1-haploinsufficient mice, a model for Dravet syndrome, exhibit learning impairment and autistic-like behaviors2011
- Author(s)
  Ogiwara I, Ito S, Yamada K, Yamakawa K
- Organizer
  Neuroscience 2011
- Place of Presentation
  米国Washington 特別区
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Scn1a-GFP BAC transgenic mouse lines showed predominant Nav1.1 expression in parvalbumin-positive interneurons in neocortex and hippocampus.2011
- Author(s)
  Ogiwara, I., Mazaki, E., Itohara, S., Yamakawa, K.
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] 難治てんかんに認められたde novo電位依存性ナトリウムチャネルα2(SCN2A)遺伝子変異2010
- Author(s)
  荻原郁夫、真崎恵美、井上育代、伊藤公一、金田誠、沢石由記夫、小坂仁、藤原建樹、井上有史、山川和弘
- Organizer
  第44回日本てんかん学会
- Place of Presentation
  岡山県岡山市
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] 電位依存性ナトリウムチャネルβ1(SCN1B)遺伝子にホモ接合型変異を認めたDravet症候群1症例2010
- Author(s)
  荻原郁夫
- Organizer
  第52回日本小児神経学会総会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] Scn1a-GFP BAC transgenic mouse lines showed predominant expression of Nav1.1 in parvalbumin-positive interneurons2010
- Author(s)
  Ogiwara I.
- Organizer
  Neuroscience 2010
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] 電位依存性ナトリウムチャネルα2遺伝子とてんかん2010
- Author(s)
  荻原郁夫、中山東城、真崎恵美、井上育代、伊藤公一、金田誠、宮本浩行、Takao K. Hensch、沢石由記夫、小坂仁、藤原建樹、井上有史、山川和弘
- Organizer
  日本人類遺伝学会第55回大会
- Place of Presentation
  埼玉県大宮市
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] Scn1a-GFP BAC transgenic mouse lines showed predominant expression of Nav1.1 in parvalbumin-positive interneurons2010
- Author(s)
  Ogiwara I, Tokonami N, Mazaki E,Inoue I, Yamakawa K.
- Organizer
  Neuroscience 2010
- Place of Presentation
  米国San Diego市
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] Analysis of SCN1A expression using BAC transgenic mice2010
- Author(s)
  Ogiwara I.
- Organizer
  2010 Gordon Conference on Mechanisms of Epilepsy and Neuronal Synchronization
- Place of Presentation
  Waterville, ME, USA
- Year and Date
  2010-08-11
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] 難治てんかんに認められたde nova電位依存性ナトリウムチャネルα2(SCN2A)遺伝子変異2010
- Author(s)
  荻原郁夫
- Organizer
  第44回日本てんかん学会
- Place of Presentation
  岡山県岡山市
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] Scn1a mice exhibit hyperactivity, autism-like behavioral deficits and learning impairments2010
- Author(s)
  Ogiwara I, Ito S, Yamada K, Yamakawa K.
- Organizer
  Neuro 2010
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] Analysis of SCN1A expression using BAC transgenic mice2010
- Author(s)
  Ogiwara I, Tokonami N, Mazaki E, Yamakawa K.
- Organizer
  2010 Gordon Conference on Mechanisms of Epilepsy and Neuronal Synchronization
- Place of Presentation
  米国Waterville市
- Year and Date
  2010-08-11
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] 電位依存性ナトリウムチャネルβ1(SCN1B)遺伝子にホモ接合型変異を認めたDravet症候群1例2010
- Author(s)
  荻原郁夫、中山東城、芳村勝城、藤原建樹、井上有史、山川和弘
- Organizer
  第52回日本小児神経学会総会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] Analysis of alternative promoters of voltage-gated Na^+ channelα_I gene2009
- Author(s)
  Ogiwara I, Ito K, Mazaki E, Kaneda M, Yamakawa K.
- Organizer
  Neuroscience 2009
- Place of Presentation
  米国Chicago市
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] Analysis of alternative promoters of voltage-gated Na^+ channel α_I gene2009
- Author(s)
  荻原郁夫
- Organizer
  Neuroscience 2009
- Place of Presentation
  米国 Chicago 市
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] 難治性乳幼児てんかんに認められたde novo電位依存性ナトリウムチャネルα2遺伝子変異2009
- Author(s)
  荻原郁夫、沢石由記夫、小坂仁、藤原建樹、井上有史、山川和弘
- Organizer
  第51回日本小児神経学会総会
- Place of Presentation
  鳥取県米子市
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] マウス小脳プルキンエ細胞における電位依存性ナトリウムチャネルα1遺伝子の発現解析2009
- Author(s)
  荻原郁夫、伊藤公一、真崎恵美、金田誠、山川和弘
- Organizer
  日本人類遺伝学会第54回大会
- Place of Presentation
  東京都港区
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] 難治性乳幼児てんかんに認められた de novo 電位依存性ナトリウムチャネルα2遺伝子変異2009
- Author(s)
  荻原郁夫
- Organizer
  第51回日本小児神経学会総会
- Place of Presentation
  鳥取県米子市
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] Analysis of voltage-gated sodium channel α1 expression using BAC transgenic mice2009
- Author(s)
  荻原郁夫
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] Analysis of voltage-gated sodium channelα1 expression using BAC transgenic mice2009
- Author(s)
  Ogiwara I, Mazaki E, Itohara S, Yamakawa K.
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21791020
[Presentation] Mutation analysis of the voltage-gated sodium channel alpha II gene in patients with early childhood intractable epilepsies2008
- Author(s)
  Ogiwara, I., Ito, K., Osaka, H., Mazaki, E., Inoue, I., Fujiwara, T., Inoue, Y., Kaneda, M., Yamakawa,K.
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington, D.C
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] Voltage-gated Na+ channel α1 gene is transcribed from two widely separated promoters2008
- Author(s)
  荻原郁夫,伊藤公一,真崎恵美,金田誠,山川和弘
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] 電位依存性ナトリウムチャネルα2遺伝子変異を認めた点頭てんかん1症例2008
- Author(s)
  荻原郁夫、伊藤公一、真崎恵美、井上育代、四家達彦、藤原建樹、井上有史、金田誠、山川和弘
- Organizer
  第42回日本てんかん学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] 難治性乳幼児てんかんに認められた電位依存性ナトリウムチャネルα2遺伝子変異電位2008
- Author(s)
  荻原郁夫、伊藤公一、小坂仁、真崎恵美、井上育代、四家達彦、藤原建樹、井上有史、金田誠、山川和弘
- Organizer
  日本人類遺伝学会第53回大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] 電位依存性ナトリウムチャネルα1(SCN1A)遺伝子変異とてんかん2008
- Author(s)
  荻原郁夫、山川和弘
- Organizer
  第50回日本小児神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] Navl. 1 predominantly localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in Navl. 1-deficient mice2007
- Author(s)
  Ogiwara, I.
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] Nav1.1 predominantly localizes to axons in the developing mouse brain2007
- Author(s)
  Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Itohara, S., Yanagawa, Y., Obata, K., Furuichi, T., Hensch, T.K., Yamakawa, K.
- Organizer
  Neuroscience 2007
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] Epileptic seizures in mice carrying a premature stop codon in the voltage-gated sodium channel alpha 1 gene: a model for human severe myoclonic epilepsy in infancy2007
- Author(s)
  Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa, Y., Obata, K., Furuichi, T., Hensch, T. K., Yamakawa, K
- Organizer
  第30回日本神経科学大会サテライトシンポジウム
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] Nav1.1 predominantly localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in Nav1.1-deficient mice2007
- Author(s)
  荻原郁夫,宮本浩行,森田規之,アタポアナフィセ,真崎恵美,井上育代,柳川右千夫,小幡邦彦,ヘンシュ K. 貴雄,古市貞一,山川和弘
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] 乳児重症ミオクロニーてんかんモデルマウスにおける大脳皮質抑制性神経細胞の異常2007
- Author(s)
  荻原郁夫,森田規之,アタポアナフィセ,宮本浩行,井上育代,真崎恵美,柳川右千夫,小幡邦彦,ヘンシュ貴雄,古市貞一,山川和弘
- Organizer
  第41回日本てんかん学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] Navl. 1 predominantly localizes to axons in the developing mouse brain2007
- Author(s)
  Ogiwara, I.
- Organizer
  Neuroscience 2007
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] てんかんと電位依存性ナトリウムチャネル遺伝子変異2007
- Author(s)
  荻原郁夫、真崎恵美、井上育代、森本昌史、小坂仁、萩野谷和裕、井上有史、藤原建樹、山川和弘
- Organizer
  日本人類遺伝学会第52回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790747
[Presentation] 電位依存性ナトリウムチャネルα2（Scn2a）遺伝子変異マウスに認められたけいれん感受性の亢進
- Author(s)
  荻原郁夫
- Organizer
  第54回日本小児神経学会総会
- Place of Presentation
  北海道札幌市
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] Nav1.1 haploinsufficient excitatory and inhibitory neurons play distinct roles in the epileptic pathology in Dravet syndrome model mice
- Author(s)
  Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S, Yamakawa
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego Convention Center, San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] Heart rate variability analysis reveals altered autonomic tone in a mouse model of Dravet syndrome
- Author(s)
  Auerbach DS, Clawson BC, Ogiwara I, Yamakawa K, Meisler MH, Parent JM, Isom LL
- Organizer
  American Epilepsy Society 67th annual meeting
- Place of Presentation
  Walter E. Washington Convention Center, Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] 抑制性神経細胞のNav1.1ハプロ不全がてんかんの原因で、興奮性神経細胞のNav1.1ハプロ不全は症状を軽減する
- Author(s)
  荻原郁夫、岩里琢治、宮本浩行、岩田亮平、山形哲司、眞崎恵美、柳川右千夫、玉巻伸章、ヘンシュ貴雄、糸原重美、山川和弘
- Organizer
  第47回日本てんかん学会学術集会
- Place of Presentation
  福岡県北九州市北九州国際会議場
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] Selective deletion of the Scn1a gene encoding voltage-gated sodium channel α1 in parvalbumin positive cells in mice triggers epileptic seizures.
- Author(s)
  Ogiwara I
- Organizer
  第46回日本てんかん学会
- Place of Presentation
  東京都千代田区
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] パルブアルブミン陽性細胞を標的としたScn1a遺伝子破壊はマウスにてんかん発作と運動失調を引き起こす
- Author(s)
  荻原郁夫、山川和弘
- Organizer
  第55回日本小児神経学会総会
- Place of Presentation
  大分県大分市iichiko総合文化センター
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] Deletion of a voltage-gated sodium channel αI, Nav1.1, in parvalbumin-positive interneurons confers epileptic seizures in mice.
- Author(s)
  Ogiwara I
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-23791202
[Presentation] SCN1A遺伝子の抑制性細胞特異的ノックアウトは高致死性てんかんを生じるが、興奮性細胞特異的ノックアウトで生存率が上昇する
- Author(s)
  荻原郁夫、岩里琢治、宮本浩行、岩田亮平、山形哲司、眞崎恵美、柳川右千夫、玉巻伸章、ヘンシュ貴雄、糸原重美、山川和弘
- Organizer
  日本人類遺伝学会第58回大会
- Place of Presentation
  宮城県仙台市江陽グランドホテル
- Data Source
  KAKENHI-PROJECT-25461572
[Presentation] Nav1.1 haploinsufficient excitatory and inhibitory neurons play distinct roles in epilepsy
- Author(s)
  Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S, Yamakawa K
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  京都府京都市国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25461572

1. Hirose Shinichi (60248515)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. YAMAKAWA Kazuhiro (30241235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. KANEDA Makoto (30214480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. ISHII Toshiyuki (10643140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. AKAGI Takumi (50192878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 石井敦士 (90568825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 桂林秀太郎 (50435145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田中泰圭 (50714466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 道具伸也 (60399186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MAZAKI Emi

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
11. USUI Sumiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Suzuki Chiaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岩里琢治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 宮崎晴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 貫名信行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 小坂仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ogiwara Ikuo 荻原 郁夫

OGIWARA Ikuo 荻原 郁夫

Research Projects

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Co-Researchers

Establishment of a practical pipeline to develop drugs for intractable epilepsies based on their uncovered molecular pathomechanisms

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Protein-protein interactions as potential therapeutic targets for epileptic encephalopathyPrincipal Investigator

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Fundamental Research for an Innovative Drug Discovery Based on the Molecular Pathomechanisms of Refractory Epilepsy Using a Multidimensional Approach.

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Proteins interacting with Nav1.1 may be potential therapeutic targets for epilepsyPrincipal Investigator

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Analysis of interacting-partners of Nav1.1 in premature mouse brainPrincipal Investigator

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Molecular pathophysiology of neurodevelopmental disorders associated with mutations in the genes encoding voltage-gated sodium channelsPrincipal Investigator

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Molecular pathology of neurodevelopmental disorders associated with mutations of voltage-gated sodium channel genePrincipal Investigator

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Molecular pathology of epilepsy associated with mutations of voltage-gated sodium channel genePrincipal Investigator

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Molecular pathology of epilepsy associated with mutations of voltage-gated sodium channel genePrincipal Investigator

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ナトリウムチャネル遺伝子変異によって引き起こされるてんかん発病機序の解明Principal Investigator

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Investigation of the pathology for epileptic sodium channelopathy

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[Journal Article] Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons2021

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[Journal Article] CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice2020

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Ogiwara Ikuo 荻原郁夫

OGIWARA Ikuo 荻原郁夫