Hashimoto Naozumi 橋本直純

… Alternative Names

HASHIMOTO Naozumi 橋本直純

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Researcher Number	30378020
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 藤田医科大学, 医学部, 教授 2020 – 2021: 名古屋大学, 医学系研究科, 准教授 2014 – 2016: 名古屋大学, 医学部附属病院, 講師 2012 – 2014: 名古屋大学, 医学部附属病院, 病院講師 2007 – 2012: Nagoya University, 医学部附属病院, 助教 … More 2011: 名古屋大学, 医学系研究科, 助教 2008: Nagoya University, 医学部・附属病院, 助教 2006: 名古屋大学, 大学院医学系研究科, COE研究員 2005: 名古屋大学, 大学院・医学系研究科, COE研究員 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related / Medium-sized Section 53:Organ-based internal medicine and related fields Except Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related / Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator 線維芽細胞 / 肺線維症 / 上皮間葉系移行 / 微小環境 / PTEN / 血管内皮細胞 / 呼吸器病学 / 再生医療 / 線維症 / 診断 … More / 人工知能 / マイクロCT / 金ナノ粒子 / 上皮細胞 / 細胞内導入デリバリーシステム / 分子細胞尾呼吸器学 / Lung Cancer / Fibrosis / TGFbe-ta / TGFbeta / 肺癌 / 低酸素 / 血管内皮間葉系細胞転換 / 移植・再生医療 / 細胞・組織 / 移植・再生医 / 再生医学 / 形質転換 / 骨髄幹細胞 … More Except Principal Investigator 肺癌 / 肺線維症 / EMT / 上皮間葉系細胞転換 / セクレトーム / 細胞系統解析 / 間葉系細胞 / マクロファージ / ミトコンドリア / DAMPS / 急性増悪 / ミトコンドリアDNA / 好酸球性肺疾患 / アレルギー性肺疾患 / 2型炎症 / 2型自然リンパ球 / 好塩基球 / 肺傷害 / 再生医療 / 肺構成細胞 / 上皮間葉系移行 / 組織微小環境 / PTEN / 低酸素 / 肺の再生 / リンパ節転移 / 呼吸器内科 / 内科 / VEGF / HIF1α / リンパ節 / 肺がん / 呼吸器病学 / 上皮細胞接着分子 / 癌転移 / Twist遺伝子 / ZEB1 / EMT関連遺伝子 / マイクロフルイディクス / 循環血液中癌細胞 / ルイス肺癌 / アポトーシス / 血管内皮細胞 / 癌の転移 / Notch受容体 Less

革新技術を融合した繰り返し実施可能な閉塞性細気管支炎に対する非侵襲診断法の確立Principal Investigator
- Principal Investigator
  
  橋本直純
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Fujita Health University
identification of its origin, cell-fate, and mechanisms of novel antifibrotic cell population in the lung
- Principal Investigator
  
  阪本考司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nagoya University
好塩基球を介した2型炎症調節機構の解明ーアレルギー性・好酸球性肺疾患と肺恒常性
- Principal Investigator
  
  若原恵子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Nagoya University
間質性肺炎急性増悪病態における新規病的微小環境因子・ミトコンドリアＤＮＡの役割
- Principal Investigator
  
  阪本考司
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nagoya University
Immune-pathological diagnostic artificial intelligence development research for pulmonary fibrosis using fibrotic foci-specific enhanced micro-CTPrincipal Investigator
- Principal Investigator
  
  Hashimoto Naozumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Fujita Health University
  Nagoya University
The development of new therapy for pulmonary fibrosis by using exogenous protein delivery system mimicked biological mechanismPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO NAOZUMI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University
New therapeutic strategy targeting phosphorylation sites of the PTEN C-terminus for lung epithelial/endothelial-mesenchymal transitionPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Naozumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University
Molecular Target of Regenerative Pulmonary Medicine for Chronic Obstructive Pulmonary Disease
- Principal Investigator
  
  HASEGAWA Yoshinori
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University
Exploration of new therapy and diagnosis in lymph metastasis of lung cancer based on theprofile of lymphangiogenic-related genes expression
- Principal Investigator
  
  IMAIZUMI Kazuyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Fujita Health University
  Nagoya University
Analysis of cancer metastasis using circulating tumor cells purified by micro-fluidics techniques
- Principal Investigator
  
  HASEGAWA Yoshinori
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University
The establishment of therapeutic strategy for pulmonary fibrosis and pulmonary hypertension in targeting endothelial-mesenchymal transitionPrincipal Investigator
- Principal Investigator
  
  HASHIIMO Naozumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University
Lung regenerative medicine using fibroblasts-derived stem cell line with stem cell inducing factorsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Naozumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University
上皮間葉系細胞転換(EMT)分子(NOTCH)を標的にした固形癌制御の研究
- Principal Investigator
  
  長谷川好規
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University
線維芽細胞の起源再考からの肺線維症の病態解明Principal Investigator
- Principal Investigator
  
  橋本直純
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University

[Book] 最新ガイドラインに基づく呼吸器疾患診療指針 2023-’24 　第2章「閉塞性肺疾患」閉塞性細気管支炎2022
- Author(s)
  橋本　直純、長谷川好規
- Total Pages
  472
- Publisher
  総合医学社
- ISBN
  4883789365
- Data Source
  KAKENHI-PROJECT-20K21599
[Journal Article] Cohort study to evaluate prognostic factors in idiopathic pulmonary fibrosis patients introduced to oxygen therapy2023
- Author(s)
  Kataoka K, Oda K, Takizawa H, Ogura T, Miyamoto A, Inoue Y, Akagawa S, Hashimoto S, Kishaba T, Sakamoto K, Hamada N, Kuwano K, Nakayama M, Ebina M, Enomoto N, Miyazaki Y, Atsumi K, Izumi S, Tanino Y, Ishii H, Ohnishi H, Suda T, Kondoh Y
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 13664-13664
- DOI
  10.1038/s41598-023-40508-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08202
[Journal Article] Protective role of Nrf2 in zinc oxide nanoparticles-induced lung inflammation in female mice and sexual dimorphism in susceptibility2022
- Author(s)
  Sehsah Radwa、Wu Wenting、Ichihara Sahoko、Hashimoto Naozumi、Zong Cai、Yamazaki Kyoka、Sato Harue、Itoh Ken、Yamamoto Masayuki、Elsayed Ahmed Ali、El-Bestar Soheir、Kamel Emily、Ichihara Gaku
- Journal Title
  
  Toxicology Letters
  
  Volume: 370 Pages: 24-34
- DOI
  10.1016/j.toxlet.2022.09.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17277, KAKENHI-PROJECT-20H03935, KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-20K21725
[Journal Article] BMP3b Is a Novel Antifibrotic Molecule Regulated by Meflin in Lung Fibroblasts2022
- Author(s)
  Suzuki Atsushi、Sakamoto Koji、Nakahara Yoshio、Enomoto Atsushi、Hino Jun、Ando Akira、Inoue Masahide、Shiraki Yukihiro、Omote Norihito、Kusaka Masahiro、Fukihara Jun、Hashimoto Naozumi
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: 67 Issue: 4 Pages: 446-458
- DOI
  10.1165/rcmb.2021-0484oc
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08202, KAKENHI-PROJECT-22K18390, KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-18K15948
[Journal Article] COVID-19-Triggered Acute Exacerbation of IPF, an Underdiagnosed Clinical Entity With Two-Peaked Respiratory Failure: A Case Report and Literature Review2022
- Author(s)
  Goto Yosuke、Sakamoto Koji、Fukihara Jun、Suzuki Atsushi、Omote Norihito、Ando Akira、Shindo Yuichiro、Hashimoto Naozumi
- Journal Title
  
  Frontiers in Medicine
  
  Volume: 9 Pages: 815924-815924
- DOI
  10.3389/fmed.2022.815924
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08517, KAKENHI-PROJECT-21K08202, KAKENHI-PROJECT-18K15948
[Journal Article] A comprehensible machine learning tool to differentially diagnose idiopathic pulmonary fibrosis from other chronic interstitial lung diseases2022
- Author(s)
  Furukawa T, Oyama S, Yokota H, Kondoh Y, Kataoka K, Johkoh T, Fukuoka J, Hashimoto N,Sakamoto K, Shiratori Y, Hasegawa Y
- Journal Title
  
  Respirology
  
  Volume: 27 Issue: 9 Pages: 739-746
- DOI
  10.1111/resp.14310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-18K15948, KAKENHI-PROJECT-19K17633
[Journal Article] Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor β-induced profibrotic responses in lung fibroblasts2022
- Author(s)
  Fukihara Jun、Maiolo Suzanne、Kovac Jessica、Sakamoto Koji、Wakahara Keiko、Hashimoto Naozumi、Reynolds Paul N.
- Journal Title
  
  Experimental Lung Research
  
  Volume: 48 Issue: 1 Pages: 35-51
- DOI
  10.1080/01902148.2021.2024301
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08202, KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-18K15948
[Journal Article] Successful Treatment with High-dose Steroids for Acute Exacerbation of Idiopathic Pulmonary Fibrosis Triggered by COVID-192022
- Author(s)
  Omote Norihito、Kanemitsu Yoshihiro、Inoue Takahiro、Yonezawa Toshiyuki、Ichihashi Takuji、Shindo Yuichiro、Sakamoto Koji、Ando Akira、Suzuki Atsushi、Niimi Akio、Ito Satoru、Imaizumi Kazuyoshi、Hashimoto Naozumi
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 2 Pages: 233-236
- DOI
  10.2169/internalmedicine.8163-21
- NAID
  130008141771
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-01-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08517, KAKENHI-PROJECT-21K08202, KAKENHI-PROJECT-18K15948
[Journal Article] Oxytocin receptor is a promising therapeutic target of malignant mesothelioma2021
- Author(s)
  Oxytocin receptor is a promising therapeutic target of malignant mesothelioma. Kodama Y, Tanaka I, Sato T, Hori K, Gen S, Morise M, Matsubara D, Sato M, Sekido Y, Hashimoto N.
- Journal Title
  
  Cancer science
  
  Volume: 112 Issue: 9 Pages: 3520-3532
- DOI
  10.1111/cas.15025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22617, KAKENHI-PROJECT-19H03527, KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-20H03689
[Journal Article] Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state.2021
- Author(s)
  Omote N, Sakamoto K, Li Q, Schupp JC, Adams T, Ahangari F, Chioccioli M, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N.
- Journal Title
  
  Physiol Rep.
  
  Volume: 9 Issue: 3
- DOI
  10.14814/phy2.14727
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15948, KAKENHI-PROJECT-20K21599
[Journal Article] Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages2021
- Author(s)
  Masahide Inoue, Koji Sakamoto, Atsushi Suzuki, Shinya Nakai, Akira Ando, Yukihiko Shiraki, Yoshio Nakahara, Mika Omura, Atsushi Enomoto, Ikuhiko Nakase, Makoto Sawada, Naozumi Hashimoto
- Journal Title
  
  Particle and Fibre Toxicology
  
  Volume: 18 Issue: 1 Pages: 21-21
- DOI
  10.1186/s12989-021-00415-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20463, KAKENHI-PROJECT-21K08202, KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-18K15948
[Journal Article] Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis2021
- Author(s)
  Nakahara Y, Hashimoto N, Sakamoto K, Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y.
- Journal Title
  
  European Respiratory Journal
  
  Volume: 58 Issue: 6 Pages: 2003397-2003397
- DOI
  10.1183/13993003.03397-2020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07824, KAKENHI-PROJECT-21K08202, KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-18K15948, KAKENHI-PROJECT-20H03467
[Journal Article] Clinical burden of immune checkpoint inhibitor-induced pneumonitis2020
- Author(s)
  Sakamoto Koji、Fukihara Jun、Morise Masahiro、Hashimoto Naozumi
- Journal Title
  
  Respiratory Investigation
  
  Volume: 58 Issue: 5 Pages: 305-319
- DOI
  10.1016/j.resinv.2020.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07910, KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-18K15948
[Journal Article] Serum mitochondrial DNA predicts the risk of acute exacerbation and progression of idiopathic pulmonary fibrosis2020
- Author(s)
  Sakamoto Koji、Furukawa Taiki、Yamano Yasuhiko、Kataoka Kensuke、Teramachi Ryo、Walia Anjali、Suzuki Atsushi、Inoue Masahide、Nakahara Yoshio、Ryu Changwan、Hashimoto Naozumi、Kondoh Yasuhiro
- Journal Title
  
  European Respiratory Journal
  
  Volume: 57 Issue: 1 Pages: 2001346-2001346
- DOI
  10.1183/13993003.01346-2020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21599, KAKENHI-PROJECT-18K15948
[Journal Article] Probable usual interstitial pneumonia pattern on chest CT: is it sufficient for a diagnosis of idiopathic pulmonary fibrosis?2020
- Author(s)
  Fukihara Jun、Kondoh Yasuhiro、Brown Kevin K.、Kimura Tomoki、Kataoka Kensuke、Matsuda Toshiaki、Yamano Yasuhiko、Suzuki Atsushi、Furukawa Taiki、Sumikawa Hiromitsu、Takahashi Osamu、Johkoh Takeshi、Tanaka Tomonori、Fukuoka Junya、Hashimoto Naozumi、Hasegawa Yoshinori
- Journal Title
  
  European Respiratory Journal
  
  Volume: 55 Issue: 4 Pages: 1802465-1802465
- DOI
  10.1183/13993003.02465-2018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21599
[Journal Article] Impact of thin-section computed tomography-determined combined pulmonary fibrosis and emphysema on outcomes among patients with resected lung cancer2016
- Author(s)
  Hashimoto N, Iwano S, Kawaguchi K, Fukui T, Fukumoto K, Nakamura S, Mori S, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y.
- Journal Title
  
  Ann Thorac Surg
  
  Volume: 102 Pages: 440-447
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15322
[Journal Article] Clinical impact of the lower limit of normal of FEV1/FVC on survival in lung cancer patients undergoing thoracic surgery2016
- Author(s)
  Matsuzaki A, Hashimoto N, Okachi S, Taniguchi T, Kawaguchi K, Fukui T, Wakai K, Yokoi K, Hasegawa Y.
- Journal Title
  
  Respir Investig
  
  Volume: 54 Pages: 184-192
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15322
[Journal Article] Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers2016
- Author(s)
  Kohnoh T, Hashimoto N, Ando A, Sakamoto K, Miyazaki S, Aoyama D, Kusunose M, Kimura M, Omote N, Imaizumi K, Kawabe T, Hasegawa Y.
- Journal Title
  
  Cancer Cell International
  
  Volume: 16 Pages: 33-42
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15322
[Journal Article] Antineutrophil Cytoplasmic Antibody-associated Vasculitis Superimposed on Infection-related Glomerulonephritis Secondary to Pulmonary Mycobacterium avium Complex Infection2016
- Author(s)
  Asano S, Mizuno S, Okachi S, Aso H, Wakahara K, Hashimoto N, Ito S, Kozaki Y, Katsuno T, Maruyama S, Hasegawa Y.
- Journal Title
  
  Intern Med
  
  Volume: 55 Pages: 2439-2445
- NAID
  130005262546
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15322
[Journal Article] Factors Affecting the Diagnostic Yield of Transbronchial Biopsy Using Endobronchial Ultrasonography with a Guide Sheath in Peripheral Lung Cancer2016
- Author(s)
  Okachi S, Imai N, Imaizumi K, Iwano S, Ando M, Hase T, Aso H, Morise M, Wakahara K, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y.
- Journal Title
  
  Intern Med
  
  Volume: 55 Pages: 1705-1712
- NAID
  130005161019
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15322
[Journal Article] Bronchus sign on thin-section computed tomography is a powerful predictive factor for successful transbronchial biopsy using endobronchial ultrasound with a guide sheath for small peripheral lung lesions: a retrospective observational study.2015
- Author(s)
  Minezawa T, Okamura T, Yatsuya H, Yamamoto N, Morikawa S, Yamaguchi T, Morishita M, Niwa Y, Takeyama T, Mieno Y, Hoshino T, Uozu S, Goto Y, Hayashi M, Isogai S, Matsuo M, Nakanishi T, Hashimoto N, Okazawa M, Imaizumi K.
- Journal Title
  
  BMC Medical Imaging
  
  Volume: 21 Pages: 21-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15322
[Journal Article] Risk stratification by the lower limit of normal of FEV1/FVC for postoperative outcomes in patients with COPD undergoing thoracic surgery.2015
- Author(s)
  Osuka S, Hashimoto N, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y.
- Journal Title
  
  Respir Investig
  
  Volume: 53 Issue: 3 Pages: 117-123
- DOI
  10.1016/j.resinv.2015.01.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15322
[Journal Article] Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells.2015
- Author(s)
  Kusunose M, Hashimoto N, Kimura M, Ogata R, Aoyama D, Sakamoto K, Miyazaki S, Ando A, Omote N, Imaizumi K, Kawabe T, Hasegawa Y.
- Journal Title
  
  Cancer Science
  
  Volume: 106 Issue: 12 Pages: 1693-704
- DOI
  10.1111/cas.12831
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09198, KAKENHI-PROJECT-15K15322
[Journal Article] Evaluation of emphysema using three-dimensional computed tomography: association with postoperative complications in lung cancer patients.2015
- Author(s)
  Kawakami K, Iwano S, Hashimoto N, Hasegawa Y, Naganawa S.
- Journal Title
  
  Nagoya J Med Sci
  
  Volume: 77 Pages: 113-122
- NAID
  120005549557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15322
[Journal Article] Factors secreted from dental pulp stem cells show multifaceted benefits for treating acute respiratory distress syndrome in mice.2015
- Author(s)
  Wakayama H, Hashimoto N, Matsushita Y, Matsubara K, Yamamoto N, Hasegawa Y, Ueda M, Yamamoto A
- Journal Title
  
  Cytotherapy
  
  Volume: 17 Issue: 8 Pages: 1119-1129
- DOI
  10.1016/j.jcyt.2015.04.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15322
[Journal Article] Synergistic Effect of Bolus Exposure to Zinc Oxide Nanoparticles on Bleomycin-Induced Secretion of Pro-Fibrotic Cytokines without Lasting Fibrotic Changes in Murine Lungs.2014
- Author(s)
  Wu W, Ichihara G, Hashimoto N, Hasegawa Y, Hayashi Y, Tada-Oikawa S, Suzuki Y, Chang J, Kato M, D'Alessandro-Gabazza CN, Gabazza EC, Ichihara S.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 16 Pages: 660-676
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Lobar analysis of collapsibility indices to assess functional lung volumes in COPD patients2014
- Author(s)
  Kitano M, Iwano S, Hashimoto N, Matsuo K, Hasegawa Y, Naganawa S
- Journal Title
  
  Int J Chron Obstruct Pulmon Dis.
  
  Volume: 9 Pages: 1347-1356
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Clinical impact of prevalence and severity of COPD on the decision-making process for therapeutic management of lung cancer patients.2014
- Author(s)
  Hashimoto N, Matsuzaki A, Okada Y, Imai N, Iwano S, Wakai K, Imaizumi K, Yokoi K, Hasegawa Y.
- Journal Title
  
  BMC Pulm Med
  
  Volume: 14 Pages: 14-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury.2014
- Author(s)
  Takashima K, Matsushima M, Hashimoto K, Nose H, Sato M, Hashimoto N, Hasegawa Y, Kawabe T.
- Journal Title
  
  Respir Res.
  
  Volume: 15 Pages: 150-150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Prospective analysis of efficacy and safety of an individualized-midazolam-dosing protocol for sedation during prolonged bronchoscopy.2014
- Author(s)
  Ogawa T, Imaizumi K, Hashimoto I, Shindo Y, Imai N, Uozu S, Shimokata T, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y
- Journal Title
  
  Respir Investig
  
  Volume: 52 Issue: 3 Pages: 153-159
- DOI
  10.1016/j.resinv.2013.09.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells.2013
- Author(s)
  Aoyama D#, Hashimoto N#*, Sakamoto K, Kohnoh T, Kusunose M, Kimura M, Ogata R, Imaizumi K, Kawabe T, Hasegawa Y.
- Journal Title
  
  Plos One
  
  Volume: 8(11) Issue: 11 Pages: e81133-e81133
- DOI
  10.1371/journal.pone.0081133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Anaqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans2013
- Author(s)
  Hashimoto I, Imaizumi K, Hashimoto N, Furukawa H, Noda Y, Kawabe T, Honda T, Ogawa T, Matsuo M, Imai N, Ito S, Sato M, Kondo M, Shimokata K, Hasegawa Y
- Journal Title
  
  Respirology
  
  Volume: 18(2) Issue: 2 Pages: 340-7
- DOI
  10.1111/j.1440-1843.2012.02286.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590856, KAKENHI-PROJECT-22590857
[Journal Article] Endobronchial ultrasound transbronchial needle aspiration in older people2013
- Author(s)
  Okachi S, Imai N, Imaizumi K, Hase T,Shindo Y, Sakamoto K, Aso H, Wakahara K,Hashimoto I, Ito S, Hashimoto N, Sato M,Kondo M, Hasegawa Y.
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 13 Issue: 4 Pages: 986-992
- DOI
  10.1111/ggi.12043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] An aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans.2013
- Author(s)
  Hashimoto I, Imaizumi K, Hashimoto N,Furukawa H, Noda Y, Kawabe T, Honda T,Ogawa T, Matsuo M, Imai N, Ito S, Sato M,Kondo M, Shimokata K, Hasegawa Y.
- Journal Title
  
  Respirology
  
  Volume: 18(2) Pages: 340-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice2013
- Author(s)
  Ohno T, Okamoto M, Hara T, Hashimoto N,Imaizumi K, Matsushima M, Nishimura M,Shimokata K, Hasegawa Y, Kawabe T
- Journal Title
  
  Immunogenetics
  
  Volume: 65(1) Pages: 17-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Acute exacerbation of IPF following diagnostic bronchoalveolar lavage procedures.2012
- Author(s)
  Sakamoto K, Taniguchi H, Kondoh Y, Wakai K, Kimura T, Kataoka K, Hashimoto N,Nishiyama O, Hasegawa Y
- Journal Title
  
  Respir Med
  
  Volume: 106(3) Pages: 436-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Acute exacerbation of IPF following diagnostic broncho alveolar lavage procedures2012
- Author(s)
  Sakamoto K, Taniguchi H, Kondoh Y, Wakai K, Kimura T, Kataoka K, Hashimoto N, Nishiyama O, Hasegawa Y.
- Journal Title
  
  Respir Med
  
  Pages: 436-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells2012
- Author(s)
  Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y
- Journal Title
  
  Mol Carcinog
  
  Volume: 51 Pages: 400-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659431
[Journal Article] Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells2012
- Author(s)
  Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, Kawabe T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 417(1) Pages: 169-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury2012
- Author(s)
  Sakamoto K, Hashimoto N, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, Kusunose M, Kimura M, Kawabe T, Taniguchi H, Hasegawa Y
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659431
[Journal Article] Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells2012
- Author(s)
  Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, KawabeT.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 417(1) Pages: 169-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Inspiratory capacity as a preoperative assessment of patients undergoing thoracicsurgery2012
- Author(s)
  Matsuo M, Hashimoto N, Usami N,Imaizumi K, Wakai K, Kawabe T, Yokoi K,Hasegawa Y
- Journal Title
  
  Interact Cardiovasc Thorac Surg
  
  Volume: 14(5) Pages: 560-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Nongenomic effects of fluticasone propionate and budesonide on human airway anion secretion2012
- Author(s)
  Naozumi Hashimoto (7番目)
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 47 Pages: 645-651
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Febrile complications after endobronchial ultrasound-guided transbronchial needle aspiration for intra-pulmonary mass lesions of lung cancer-a series of 3 cases.2012
- Author(s)
  Oguri T, Imai N, Imaizumi K, Elshazley M,Hashimoto I, Hashimoto N, Hasegawa Y
- Journal Title
  
  Respir Investig
  
  Volume: 50(4) Pages: 162-165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Interstitial pneumonia and nodular regenerative hyperplasia of the liver as initial manifestations of polyarteritis nodosa2012
- Author(s)
  Tanaka I, Imaizumi K, Hashimoto I, Asai N,Yokoi T, Matsuno T, Hasegawa Y
- Journal Title
  
  Intern Med.
  
  Volume: 51(6) Pages: 635-8
- NAID
  130002061910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Non-Genomic Effects of Fluticasone Propionate and Budesonide on Human Airway Anion Secretion2012
- Author(s)
  Mizutani T, Morise M, Ito Y, Hibino Y,Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, Hasegawa Y
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 47(5) Pages: 645-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells.2012
- Author(s)
  Naozumi Hashimoto (5番目)
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 417 Pages: 169-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Acute exacerbation of IPF following diagnostic bronchoalveolar lavage procedures.2012
- Author(s)
  Naozumi Hashimoto (7番目)
- Journal Title
  
  Respir Med.
  
  Volume: 106 Pages: 436-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Acute exacerbation of IPF following diagnostic bronchoalveolar lavage procedures2012
- Author(s)
  Koji Sakamoto, Naozumi Hashimoto, 7番目
- Journal Title
  
  Respir Med
  
  Volume: 106 Pages: 436-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Inspiratory capacity as a preoperative assessment of patients undergoing thoracic surgery2012
- Author(s)
  Naozumi Hashimoto (2番目; equal contribution)
- Journal Title
  
  Interact CardioVasc Thorac Surg
  
  Volume: 14 Pages: 560-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury.2012
- Author(s)
  Naozumi Hashimoto (2番目; equal contribution)
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591162
[Journal Article] Quercetin protects against pulmonary oxidant stress via hemeoxygenase-1 induction in lung epithelial cells2012
- Author(s)
  Yuta Hayashi, Naozumi Hashimoto, 5番目
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 417 Pages: 169-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury.2012
- Author(s)
  Sakamoto K, Hashimoto N, Kondoh Y,Imaizumi K, Aoyama D, Kohnoh T,Kusunose M, Kimura M, Kawabe T,Taniguchi H, Hasegawa Y
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol
  
  Volume: 303(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 greatly attenuate bleomycine-induced lung damage2011
- Author(s)
  斎藤繁紀
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 179 Issue: 3 Pages: 1088-1094
- DOI
  10.1016/j.ajpath.2011.05.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04711, KAKENHI-PROJECT-23591382, KAKENHI-PROJECT-23659431
[Journal Article] Attenuation of TGF-ss-Stimulated Collagen Production in Fibroblasts by Quercetin-InducedHO-1.2011
- Author(s)
  Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T.
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 44(5) Pages: 614-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Capsaicinoids regulate airway anion transporters through Rhokinase- and cAMP-dependent mechanisms2011
- Author(s)
  Yoshitaka Hibino, Naozumi Hashimoto, 7番目
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 45 Pages: 684-691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Attenuation of TGF-ss-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-1.2011
- Author(s)
  Nakamura T, Matsushima M, Hayashi Y,Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 44(5) Pages: 614-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Mesenchymal Stem Cells Stably Transduced with a Dominant CCL2 Greatly Attenuate Bleomycin-Induced Mesenchymal Stem Cells Stably Transduced with a Dominant-Negative Inhibitor ofCCL2 Greatly Attenuate Bleomycin-Induced Lung Damage2011
- Author(s)
  Saito S, Nakayama T, Hashimoto N, Miyata Y, Egashira K, Nakao N, Nishiwaki S, Hasegawa M, Hasegawa Y, Naoe T.
- Journal Title
  
  Am J Pathol
  
  Volume: 179(3) Pages: 1088-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Capsaicinoids regulate airway anion transporters through Rho kinase- and cAMP-dependent mechanisms2011
- Author(s)
  Hibino Y, Morise M, Ito Y, Mizutani T, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, and Hasegawa Y
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 45(4) Pages: 684-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Involvement of the transcription factor twist in phenotype alteration throughe pithelial-mesenchymal transition in lung cancercells2011
- Author(s)
  Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.
- Journal Title
  
  Mol Carcinog
  
  Volume: E1 Issue: 5 Pages: 1-11
- DOI
  10.1002/mc.20802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987, KAKENHI-PROJECT-22590856, KAKENHI-PROJECT-22590857, KAKENHI-PROJECT-23659431
[Journal Article] Mesenchymal Stem Cells Stably Transduced with a Dominant-Negative Inhibitor of CCL2 Greatl Attenuate Bleomycin-Induced Lung Damage2011
- Author(s)
  Sigeki Saito, Naozumi Hashimoto, 3番目
- Journal Title
  
  Am J Pathol
  
  Volume: 179 Pages: 1088-1094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Attenuation of TGF-β-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-12011
- Author(s)
  Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 44(5) Issue: 5 Pages: 614-620
- DOI
  10.1165/rcmb.2010-0338oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590856, KAKENHI-PROJECT-22590857, KAKENHI-PROJECT-23659431, KAKENHI-PROJECT-23790292
[Journal Article] Mesenchymal Stem Cells Stably Transduced with a Dominant-Negative Inhibitor of CCL2 Greatly Attenuate Bleomycin-Induced Lung Damage.2011
- Author(s)
  Saito S, Nakayama T, Hashimoto N, MiyataY, Egashira K, Nakao N, Nishiwaki S, Hasegawa M, Hasegawa Y, Naoe T
- Journal Title
  
  Am J Pathol
  
  Volume: 179(3) Pages: 1088-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells.2011
- Author(s)
  Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M,Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y
- Journal Title
  
  Mol Carcinog.
  
  Volume: 51(5) Pages: 400-410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857
[Journal Article] Capsaicinoids regulate airway anion transporters through Rho kinaseandc AMP-dependent mechanisms2011
- Author(s)
  Hibino Y, Morise M, Ito Y, Mizutani T, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, and Hasegawa Y
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 45(4) Pages: 684-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Attenuation of TGF-ss-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-12011
- Author(s)
  Toshinobu Nakamura, Naozumi Hashimoto, 6番目
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 44 Pages: 614-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Capsaicinoids regulate airway anion transporters through Rho kinase- and cyclic AMP-dependent mechanisms2011
- Author(s)
  Hibino Y
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 45 Issue: 4 Pages: 684-691
- DOI
  10.1165/rcmb.2010-0332oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590857, KAKENHI-PROJECT-23659431
[Journal Article] Differential Th1/Th2 chemokine expression in interstitial pneumonia2010
- Author(s)
  Naozumi Hashimoto(4番目)
- Journal Title
  
  Am J Med Sci
  
  Volume: 339 Pages: 41-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis.2010
- Author(s)
  Hashimoto N, Hasegawa Y, et al.
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 43 Pages: 161-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390257
[Journal Article] Knockdown of ZEB1, a Master Epithelial-to-Mesenchymal Transition (EMT) Gene, Suppresses Anchorage-independent Cell Growth of Lung Cancer Cells2010
- Author(s)
  Naozumi Hashimoto(8番目)
- Journal Title
  
  Cancer Letters
  
  Volume: 296 Pages: 216-224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Heterologous regulation of anion transporters by menthol in human airway epithelial cells2010
- Author(s)
  Naozumi Hashimoto(6番目)
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 635 Pages: 204-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Endothelial-mesenchymal transition in bleomycin-inducedpulmonary fibrosis2010
- Author(s)
  Hashimoto N, Hasegawa Y, et al.(8人中8番目)
- Journal Title
  
  Am J Resp Cell Mol Biol
  
  Volume: 43 Pages: 161-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390257
[Journal Article] Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis2010
- Author(s)
  Naozumi Hashimoto
- Journal Title
  
  Am J Respir Cell Mol Blol
  
  Volume: 43 Pages: 161-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Erythromycin-induccd CXCR4 expression on microvascular endothelial cell2009
- Author(s)
  Naozumi Hashimoto
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model2009
- Author(s)
  Naozumi Hashimoto
- Journal Title
  
  BMC Pulm Med 9
  
  Pages: 45-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590987
[Journal Article] Up-regulation of Surfactant Protein Production in a Mouse Model of Secondary Pulmonary Alveolar Proteinosis2008
- Author(s)
  Shibasaki1 M, Hashimoto K, Okamoto M, Hayashi Y, Imaizumi1K, Hashimoto N, Ozaki N, Yokoi T, Takagi K, Hasegawa Y, Shimokata K, Kawabe T
- Journal Title
  
  Am J Respir Cell Mol Biol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590890
[Journal Article] TH1/TH2 immune response in lung fibroblasts in interstitial lung disease2008
- Author(s)
  Sumida A, Hasegawa Y, Okamoto M, Hashimoto N, Imaizumi K, Yatsuya H, Yokoi T, Takagi K, Shimokata K, Kawabe T
- Journal Title
  
  Arch Med Res 39
  
  Pages: 503-510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590890
[Journal Article] Healthcare-associated pneumonia among hospitalized patients in a Japanese community hospital2008
- Author(s)
  Shindo Y, Shinji Sato S, Maruyama E, Ohashi T, Ogawa M, Hashimoto N, Imaizumi K, Sato T, Hasegawa Y
- Journal Title
  
  Chest (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590890
[Journal Article] Successful re-treatment with gefitinib for carcinomatous meningitis as disease recurrence of non-small-cell lung cancer.2007
- Author(s)
  橋本直純
- Journal Title
  
  Lung Cancer 53
  
  Pages: 387-390
- Data Source
  KAKENHI-PROJECT-17790530
[Presentation] 特発性肺線維症の新規バイオマーカーミトコンドリアDNA絶対定量法の開発2023
- Author(s)
  池山賢樹、富貴原淳、阪本考司、片岡健介、古川大記、鈴木淳、日下真宏、表紀仁、橋本直純、近藤康博、石井誠
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K08202
[Presentation] mtDNA in bronchoalveolar lavage fluid is a prognostic factor for IPF and AE-IPF2023
- Author(s)
  Fukihara, J; Sakamoto, K; Furukawa, T ; Teramachi, R; Ikeyama, Y; Kataoka, K; Kondoh, Y; Hashimoto, N; Ishii, M
- Organizer
  Annual congress of the European-Respiratory-Society (ERS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08202
[Presentation] Meflin-BMP3b Axis Is a Novel Anti-Fibrotic Pathway Against TGF-βInduced Lung Fibrogenesis2022
- Author(s)
  A. Suzuki, K. Sakamoto, Y. Nakahara, A. Enomoto, J. Hino, A. Ando, M. Inoue, N. Omote, M. Kusaka, J. Fukihara, N. Hashimoto
- Organizer
  American Thoracic Society 2022 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08202
[Presentation] The PTEN protein, not lipid, phosphatase activity negatively regulate TGFβ-induced EMT in lung alveolar cells.2015
- Author(s)
  Hashimoto N, Aoyama D, Hasegawa Y
- Organizer
  The 2015 American Thoracic Society (ATS) International Conference
- Place of Presentation
  デンバー、米国
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15322
[Presentation] Modulation of Phosphorylation Sites In The PTEN C-Terminal Inhibits TGFβ-Induced EMT In Lung Cancers Via Blockade Of Translocation Of β-Catenin Into Cytoplasm”2013
- Author(s)
  Hashimoto N, Aoyama D, Hasegawa Y
- Organizer
  The 2013 American Thoracic Society (ATS) International Conference
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-24591162
[Presentation] Translocation of β-catenin into cytoplasm during TGFβ-induced EMT is negatively regulated by phosphorylation of the PTEN C-terminus in lung cancers.2013
- Author(s)
  Naozumi Hashimoto, Daisuke Aoyama, Yoshinori Hasegawa
- Organizer
  European Respiratory Society Annual Congress 2013
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24591162
[Presentation] Compensatory induction of mutated phosphorylation sites in the PTEN C-terminal suppresses tumor growth in lung cancers in vivo.2012
- Author(s)
  Naozumi Hashimoto
- Organizer
  The 2012 American Thoracic Society (ATS) International Conference
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23659431
[Presentation] Compensatory induction of mutation of phosphorylation sites in PTEN inhibits hypoxia-induced epithelial-mesenchymal transition (EMT) in epithelial cells2012
- Author(s)
  Kimura M, Hashimoto N, Kusunose M, Hasegawa Y
- Organizer
  The FASEB Summer Research Conference
- Place of Presentation
  Saxtons River, USA
- Data Source
  KAKENHI-PROJECT-23659431
[Presentation] 気管支鏡検査前スクリーニング肺機能検査は慢性閉塞性肺疾患（COPD）早期診断方法として有効性である2012
- Author(s)
  橋本直純
- Organizer
  日本呼吸器内視鏡学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590857
[Presentation] Various effect of compensatory induction of PTEN wild against TGFβ-induced epithelial-mesenchymal transition (EMT) in epithelial cells2012
- Author(s)
  Kusunose M, Hashimoto N, Kimura M, Hasegawa Y
- Organizer
  The FASEB Summer Research Conference
- Place of Presentation
  Saxtons River, USA
- Data Source
  KAKENHI-PROJECT-23659431
[Presentation] Inhibition of TGFβ-induced phenotype alterations through epithelial-mesenchymal transition (EMT) in epithelial cells by gene mutation of phosphorylation sites in PTEN2012
- Author(s)
  Hashimoto N, Kusunose M, Kimura M, Hasegawa Y
- Organizer
  The FASEB Summer Research Conference
- Place of Presentation
  Saxtons River, USA
- Data Source
  KAKENHI-PROJECT-23659431
[Presentation] Acute and persistent hypoxia differentially induces surfactant protein D modulation and epithelial-mesenchymal transition via hypoxia-inducible factor 1α and twist stimulation in acute lung injury/fibrosis2012
- Author(s)
  Naozumi Hashimoto
- Organizer
  The 2012 American Thoracic Society (ATS) International Conference
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-24591162
[Presentation] Compensatory induction of mutated phosphorylation sites in the PTEN C-terminal suppresses tumor growth in lung cancers in vivo2012
- Author(s)
  Hashimoto N, Aoyama D, Sakamoto K, Hasegawa Y
- Organizer
  The 2012 American Thoracic Society (ATS) International Conference
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23659431
[Presentation] Compensatory induction of mutated phosphorylation sites in the PTEN C-terminal suppresses tumor growth in lung cancers in vivo2012
- Author(s)
  Naozumi Hashimoto
- Organizer
  The 2012 American Thoracic Society (ATS) International Conference
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-24591162
[Presentation] Inhibition of TGFβ-induced phenotype alterations through epithelial-mesenchymal transition (EMT) in epithelial cells by gene mutation of phosphorylation sites in PTEN.2012
- Author(s)
  Naozumi Hashimoto
- Organizer
  The FASEB Summer Research Conference,
- Place of Presentation
  Saxtons River, USA
- Data Source
  KAKENHI-PROJECT-23659431
[Presentation] Spirometric inspiratory capacity is a useful preoperative assessment in patients undergoing thoracic surgery2012
- Author(s)
  Naozumi Hashimoto
- Organizer
  The 2012 American Thoracic Society (ATS) International Conference
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-24591162
[Presentation] Acute and persistent hypoxia differentially induces surfactant protein D modulation and epithelial-mesenchymal transition via hypoxia-inducible factor 1α and twist stimulation in acute lung injury/fibrosis.2012
- Author(s)
  Naozumi Hashimoto
- Organizer
  The 2012 American Thoracic Society (ATS) International Conference
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23659431
[Presentation] Acute and persistent hypoxia differentially induces surfactant protein D modulation and epithelial-mesenchymal transition via hypoxia-inducible factor 1αand twist stimulation in acute lung injury/fibrosis2012
- Author(s)
  Hashimoto N, Sakamoto K, Hasegawa Y
- Organizer
  The 2012 American Thoracic Society (ATS) International Conference
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23659431
[Presentation] A critical　involvement of chronic obstructive pulmonary disease as a preo perative risk factor in the patients with lung cancer undergoing surgical resection2011
- Author(s)
  Naozumi Hashimoto
- Organizer
  American Thoracic Society　2011
- Place of Presentation
  アメリカ、デンバー
- Year and Date
  2011-05-17
- Data Source
  KAKENHI-PROJECT-21590987
[Presentation] Inhibition of TGFbeta induced epithelial mesenchymal transition in lung cancer by modulation of PTEN c-terminal tail2011
- Author(s)
  Naozumi Hashimoto
- Organizer
  日本癌学会総会
- Place of Presentation
  日本、名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21590987
[Presentation] Modulated Expression Of Surfactant Protein D In Acute Lung Injury Might Be Associated With Epithelial-Mesenchymal Transition In Epithelial Cells.2011
- Author(s)
  Sakamoto K, Hashimoto N, Imaizumi K, Taniguchi H, Kondoh Y, Kohnoh T, Aoyama D, Ogawa T,Hasegaya Y.
- Organizer
  American Thoracic Society International Conference 2011 (ATS・2011)
- Place of Presentation
  Denver,Colorado,USA
- Data Source
  KAKENHI-PROJECT-23659431
[Presentation] Inhibition of Hypoxia-induced phenotype alterations through epithelial-mesenchymal transition(EMT) in lung cancer by gene modulation of phosphorylation sites in tumor suppressor PTEN European Respiratory Society Congress2011
- Author(s)
  Naozumi Hashimoto
- Organizer
  オランダ、アムステルダム
- Place of Presentation
  アムステルダム
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-21590987
[Presentation] A critical involvement of chronic obstructive pulmonary disease as a preoperative risk factor in the patients with lung cancer undergoing surgical resection2011
- Author(s)
  Naozumi Hashimoto
- Organizer
  American Thoracic Society 2011 International conference
- Place of Presentation
  アメリカ、デンバー
- Year and Date
  2011-05-17
- Data Source
  KAKENHI-PROJECT-21590987
[Presentation] Inhibition of TGFbeta induced epithelial mesenchymal transition in lung cancer by modulation of PTEN c-terminal tail2011
- Author(s)
  Naozumi Hashimoto
- Organizer
  日本癌学会総会
- Place of Presentation
  日本,名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21590987
[Presentation] Inhibition of Hypoxia-induced phenotype alterations through epithelial-mesenchymal transition (EMT) in lung cancer by gene modulation of phosphorylation sites in tumor suppressor PTEN2011
- Author(s)
  Naozumi Hashimoto
- Organizer
  European Respiratory Society Congress
- Place of Presentation
  オランダ、アムステルダム
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-21590987
[Presentation] Inspiratory capacity is a new preoperative risk predictor in the patients with lung cancer undergoing surgical resection2011
- Author(s)
  Naozumi Hashimoto
- Organizer
  European Respiratory Society Congress
- Place of Presentation
  オランダ、アムステルダム
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-21590987
[Presentation] Inhibition Of TGF-Beta-Induced Phenotype Alterations Through Epithelial-Mesenchymal Transition(EMT) In Lung Cancer By Gene Modulation Of Phosphorylations Sites In Tumor Suppressor Pten2011
- Author(s)
  Aoyama D, Hashimoto N, Imaizumi K, Kohnoh T, Sakamoto K, Ogawa T, Hasegaya Y.
- Organizer
  American Thoracic Society International Conference 2011 (ATS・2011)
- Place of Presentation
  Denver,Colorado,USA
- Data Source
  KAKENHI-PROJECT-23659431
[Presentation] Inspiratory capacity is a new preoperative risk predictor in the patients with lung cancer undergoing surgical resection European Respiratory Society Congress2011
- Author(s)
  Naozumi Hashimoto
- Organizer
  オランダ、アムステルダム
- Place of Presentation
  アムステルダム
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-21590987
[Presentation] A critical Involvement or chronic obstructive pulmonary disease as a preoperative risk factor in the patients with lung cancer undergoing surgical resection2011
- Author(s)
  N.Hashimoto
- Organizer
  ATS International Conference
- Place of Presentation
  Denver, Colorado USA
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22590857
[Presentation] Involvement of fibrosis-related growth factors in endothelial-mesenchymal transition2010
- Author(s)
  Naozumi Hashimoto
- Organizer
  2010 EB
- Place of Presentation
  Vermont USA
- Year and Date
  2010-08-10
- Data Source
  KAKENHI-PROJECT-21590987
[Presentation] Involvement of fibrosis-related growth factors in endothelial-mesenchymal transition2010
- Author(s)
  Naozumi Hashimoto
- Organizer
  ATS 2010 International Conference
- Place of Presentation
  New Orleans USA
- Year and Date
  2010-05-17
- Data Source
  KAKENHI-PROJECT-21590987
[Presentation] Induction of CXCR4 surface expression on microvascular endothelial cells by fourteen membered ring macrolldes.2008
- Author(s)
  Hashimoto N, et al.
- Organizer
  2008 International Conference of American Thoracic Society
- Place of Presentation
  Toronto, Canada
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-19659211
[Presentation] Comprehensive analysis of the PTEN domains on TGFβ-induced aberrant cell motility in lung alveolar/epithelial cells by using PTEN constructs with deletion mutants
- Author(s)
  Hashimoto N, Kusunose M, Aoyama　D, Kimura M, Hasegawa Y
- Organizer
  European Respiratory Society Annual Congress 2014
- Place of Presentation
  Munchen, Germany
- Year and Date
  2014-09-06 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24591162

1. HASEGAWA Yoshinori (20270986)

# of Collaborated Projects: 7 results

# of Collaborated Products: 36 results
2. 阪本考司 (00635633)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. 若原恵子 (00631433)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. IMAIZUMI Kazuyoshi (50362257)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
5. KONDO Masashi (00378077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SATO Mitsuo (70467281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. 中村彰太 (20612849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 古川大記 (30837654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 芳川豊史 (00452334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 猪股弥生 (90469792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 榎本篤 (20432255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 石井誠 (30317333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Miyazaki Shinichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. KAWABE Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. MATSUSHIMA Miyoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 宗才

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 森瀬昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 田中一大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 中瀬生彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 進藤有一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashimoto Naozumi 橋本 直純

HASHIMOTO Naozumi 橋本 直純

Research Projects

Research Products

Co-Researchers

革新技術を融合した繰り返し実施可能な閉塞性細気管支炎に対する非侵襲診断法の確立Principal Investigator

Principal Investigator

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identification of its origin, cell-fate, and mechanisms of novel antifibrotic cell population in the lung

Principal Investigator

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Research Institution

好塩基球を介した2型炎症調節機構の解明ーアレルギー性・好酸球性肺疾患と肺恒常性

Principal Investigator

Project Period (FY)

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Research Institution

間質性肺炎急性増悪病態における新規病的微小環境因子・ミトコンドリアＤＮＡの役割

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Immune-pathological diagnostic artificial intelligence development research for pulmonary fibrosis using fibrotic foci-specific enhanced micro-CTPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

The development of new therapy for pulmonary fibrosis by using exogenous protein delivery system mimicked biological mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

New therapeutic strategy targeting phosphorylation sites of the PTEN C-terminus for lung epithelial/endothelial-mesenchymal transitionPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Molecular Target of Regenerative Pulmonary Medicine for Chronic Obstructive Pulmonary Disease

Principal Investigator

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Exploration of new therapy and diagnosis in lymph metastasis of lung cancer based on theprofile of lymphangiogenic-related genes expression

Principal Investigator

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Research Institution

Analysis of cancer metastasis using circulating tumor cells purified by micro-fluidics techniques

Principal Investigator

Project Period (FY)

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Research Institution

The establishment of therapeutic strategy for pulmonary fibrosis and pulmonary hypertension in targeting endothelial-mesenchymal transitionPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Lung regenerative medicine using fibroblasts-derived stem cell line with stem cell inducing factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

上皮間葉系細胞転換(EMT)分子(NOTCH)を標的にした固形癌制御の研究

Principal Investigator

Project Period (FY)

Hashimoto Naozumi 橋本直純

HASHIMOTO Naozumi 橋本直純

[Book] 最新ガイドラインに基づく呼吸器疾患診療指針 2023-’24 　第2章「閉塞性肺疾患」閉塞性細気管支炎2022