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YOSHITOMI Osamu  吉富 修

ORCIDConnect your ORCID iD *help
Researcher Number 30380926
Other IDs
External Links
Affiliation (Current) 2025: 長崎大学, 病院(医学系), 准教授
Affiliation (based on the past Project Information) *help 2017 – 2024: 長崎大学, 病院(医学系), 准教授
2014 – 2016: 長崎大学, 病院(医学系), 講師
2011 – 2012: 長崎大学, 大学病院, 助教
2009 – 2010: 長崎大学, 病院, 助教
2008: Nagasaki University, 大学病院, 助教
2007 – 2008: Nagasaki University, 医学部・歯学部附属病院, 助教
2006: 長崎大学, 医学部・歯学部附属病院, 助手
Review Section/Research Field
Principal Investigator
Basic Section 55060:Emergency medicine-related / Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Anesthesiology
Except Principal Investigator
Basic Section 55060:Emergency medicine-related / Anesthesiology/Resuscitation studies
Keywords
Principal Investigator
心筋スタニング / 敗血症性ショック / 再灌流性不整脈 / p38MAPK / プレコンディショニング / ホスホジエステラーゼIII阻害薬 / Rho-kinase阻害薬 / phosphodiesterase-III阻害薬 / 薬理学的プレコンディショニング / 心筋虚血再灌流障害 … More / reactive oxygen species / レミマゾラム / NLRP3インフラマソーム / ベンゾジアゼピン受容体 / 心筋虚血再灌流傷害 / 心室圧容積曲線 / カルシウムハンドリング / 敗血症性心筋症 / 敗血症性心筋障害 / アポトーシス / 心筋拡張障害 / 糖尿病治療薬 / 心筋収縮力 / 敗血症 / α2受容体作動薬 / SGLT2 阻害薬 / GLP-1受容体 / 心筋虚血 / 集中治療 / 高二酸化炭素血症 / 虚血再灌流 / 心筋虚血再灌流 / 気絶心筋 / 虚血再灌流障害 / サイトカイン / 好中球エラスターゼ阻害薬 / ボスホジエステラーゼIII阻害薬 / 水素 / 心筋梗塞サイズ / カルシウム感受性増強薬 / カテコラミン / α2-adrenergic agonist / α_2アドレナリン受容体刺激薬 / cAMP / 塩酸ランジオロール / 発作性心房細動 / ミトコンドリアATP感受性Kチャネル / Rho-kinase阻害薬、p38MAPK … More
Except Principal Investigator
P-Vループ / 心筋拡張能障害 / 敗血症性心筋症 / 敗血症 / CMKⅡ阻害薬 / CAMK Ⅱ / RyR2・リアノジン受容体 / 豚敗血症生体モデル / 心筋細胞内Ca輸送 / 敗血症性心筋障害 / SERCA2A / リアノジン受容体 / 拡張障害 / ホスホランバン / ラット / 敗血症ラットモデル / 心筋拡張障害 / SERCA2a / mPTP / PI3K-Akt / Glutaredoxin / Rho-kinase阻害薬 / ミトコンドリアATP感受性Kチャネル / PI3k-AKt / ポストコンディショニング / カルシウム感受性増強薬 / プレコンディショニング / ホスホジエステラーゼIII阻害薬 / アポトーシス / 抗酸化作用 / RISK pathway / 薬理学的ポストコンディショニング / 薬理学的プレコンディショニング / 心筋スタニング / 心筋虚血再灌流障害 Less
  • Research Projects

    (9 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (6 People)
  •  Ischemic myocardial protection strategy by regulating NLRP3 inflammasome via benzodiazepine receptorPrincipal Investigator

    • Principal Investigator
      吉富 修
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Nagasaki University
  •  RyR2を標的にした新規CAMKII阻害薬による敗血症性左室拡張機能の制御

    • Principal Investigator
      石崎 泰令
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Nagasaki University
  •  カルシウムハンドリング制御による敗血症性心筋症の治療戦略Principal Investigator

    • Principal Investigator
      吉富 修
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Nagasaki University
  •  Regulation of septic left ventricular diastolic function by a novel heart failure treatment targeting SERCA2a

    • Principal Investigator
      Ishizaki HIronori
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Nagasaki University
  •  Control of apoptosis in septic cardiomyopathy and elucidation of the role of GLP-1 receptorPrincipal Investigator

    • Principal Investigator
      YOSHITOMI Osamu
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Nagasaki University
  •  Ischemic myocardial protection strategy by the balanced anesthesia-Examination by the cardiopulmonary resuscitation model-Principal Investigator

    • Principal Investigator
      YOSHITOMI Osamu
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Nagasaki University
  •  Elucidation of role of Rho-kinase in the post resuscitation syndromePrincipal Investigator

    • Principal Investigator
      YOSHITOMI Osamu
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Nagasaki University
  •  Conquest of myocardial ischemia reperfusion injury-Control of RISK pathway and antioxidant mechanism-

    • Principal Investigator
      SUMIKAWA Koji
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Nagasaki University
  •  Molecular mechanism of myocardial pharmacological preconditioning via activation of PI3K-Akt.Principal Investigator

    • Principal Investigator
      YOSHITOMI Osamu
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Nagasaki University

All 2021 2017 2013 2012 2011 2010 2009 2008 2007 2006

All Journal Article Presentation

  • [Journal Article] Tracheobronchial Stent Insertion Under Venovenous Extracorporeal Membrane Oxygenation in a Patient With Coronavirus Disease 20192021

    • Author(s)
      Ichinomiya Taiga、Murata Hiroaki、Sekino Motohiro、Yokoyama Haruka、Ogami-Takamura Keiko、Higashijima Ushio、Ashizawa Nobuyuki、Izumikawa Koichi、Machino Ryusuke、Matsumoto Keitaro、Nakaji Shun、Yoshitomi Osamu、Hara Tetsuya
    • Journal Title

      Journal of Cardiothoracic and Vascular Anesthesia

      Volume: - Issue: 8 Pages: 1-5

    • DOI

      10.1053/j.jvca.2021.09.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08921, KAKENHI-PROJECT-20K09220
  • [Journal Article] A case of acute coronary syndromes during operation, resulting in ventricular fibrillation.2017

    • Author(s)
      Yoshitomi O
    • Journal Title

      Acta Medica Nagasakiensia

      Volume: 61 Pages: 27-31

    • NAID

      130006247096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462363
  • [Journal Article] Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine2013

    • Author(s)
      Shibata I, Cho S, Yoshitomi O, Ureshino H, Maekawa T, Hara T, Sumikawa K
    • Journal Title

      Scand Cardiovasc J

      Volume: 47(1) Pages: 50-7

    • NAID

      120006985770

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591738
  • [Journal Article] Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine2012

    • Author(s)
      Sakai K, Cho S, Shibata I, Yoshitomi O, Maekawa T, Sumikawa K
    • Journal Title

      Scand Cardiovasc J

      Volume: 46(3) Pages: 183-9

    • NAID

      120006985409

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591738
  • [Journal Article] Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs.2012

    • Author(s)
      Osamu Yoshitomi
    • Journal Title

      Shock

      Volume: 38 Pages: 92-97

    • NAID

      120006985371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591738
  • [Journal Article] A new technique for post-pyloric feeding tube placement by palpation in lean critically ill patients2012

    • Author(s)
      Sekino M, Yoshitomi O, Nakamura T, Makita T, Sumikawa K
    • Journal Title

      Anaesth Intensive Care

      Volume: 40(1) Pages: 154-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591738
  • [Journal Article] Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs2012

    • Author(s)
      Yoshitomi O, Cho S, Hara T, Shibata I, Maekawa T, Ureshino H, Sumikawa K.
    • Journal Title

      Shock

      Volume: 38(1) Pages: 92-7

    • NAID

      120006985371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591738
  • [Journal Article] A p38 MAPK inhibitor blocks cardioprotective effect of post-ischemic administration of milrinone.2010

    • Author(s)
      Shibata I, Yoshitomi O, Sakai K, Cho S, Sumikawa K
    • Journal Title

      Anesthesiology 113

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390406
  • [Journal Article] Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine2010

    • Author(s)
      Akiyama D, Hara T, Yoshitomi O, Maekawa T, Cho S, Sumikawa K
    • Journal Title

      J Anesth

      Volume: 24(4) Pages: 575-81

    • NAID

      10026632664

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591738
  • [Journal Article] Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.2010

    • Author(s)
      Akiyama D, Hara T, Yoshitomi O, Maekawa T, Cho S, Sumikawa K
    • Journal Title

      J Anesth 24(4)

      Pages: 575-581

    • NAID

      10026632664

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390406
  • [Journal Article] The impact of administration time of milrinone, a phosphodiesterase III inhibitor, to protect swine myocardium against ischemia-reperfusion injury.2009

    • Author(s)
      Shibata I, Yoshitomi O, Maekawa T, Hara T, Cho S, Sumikawa K
    • Journal Title

      Masui 58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Journal Article] Effect of low-dose landiolol hydrochloride on atrial fibrillation after cardiovascular surgery in patients with low left ventricular function.2009

    • Author(s)
      Osamu Yoshitomi
    • Journal Title

      Masui 58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390406
  • [Journal Article] The impact of administration time of milrinone, a phosphodiesterase III inhibitor, to protect swine myocardium against ischemia-reperfusion injury.2009

    • Author(s)
      Shibata I, Yoshitomi O, Maekawa T, Hara T, Cho S, Sumikawa K
    • Journal Title

      Masui 58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390406
  • [Journal Article] Effect of low-dose landiolol hydrochloride on atrial fibrillation after cardiovascular surgery in patients with low left ventricular function.2009

    • Author(s)
      Yoshitomi O, Maekawa T, Makita T, Sumikawa K
    • Journal Title

      Masui 58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Journal Article] Effect of low-dose landiolol hydrochloride on atrial fibrillation after cardiovascular surgery in patients with low left ventricular function.2009

    • Author(s)
      Yoshitomi O, Maekawa T, Makita T, Sumikawa K
    • Journal Title

      Masui 58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390406
  • [Journal Article] Olprinone induced myocardial preconditioning is not attenuated by mitochondrial K-ATP channels antagonist.2008

    • Author(s)
      Matsumoto S, Cho S, Maekawa T, Yoshitomi O, Shibata I, Sumikawa K
    • Journal Title

      J Anesth 22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Journal Article] Inhaled hydrogen improves regional myocardial contractility after transient ischemia in swine.2008

    • Author(s)
      Sakai K, Cho S, Shibata I, Yoshitomi O, Ureshino H, Sumikawa K
    • Journal Title

      Anesthesiology 109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390406
  • [Journal Article] Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.2008

    • Author(s)
      Shibata I, Yoshitomi O, Use T, Ureshino H, Cho S Maekawa T, Hara T, Sumikawa K
    • Journal Title

      Cardiovascular Drugs and Therapy 22

      Pages: 293-298

    • NAID

      120006983692

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390406
  • [Journal Article] Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.2008

    • Author(s)
      Shibata I, Yoshitomi O, Use T, Ureshino H, Cho S, Maekawa T, Hara T, Sumikawa K
    • Journal Title

      Cardiovascular Drugs and Therapy 22

      Pages: 293-8

    • NAID

      120006983692

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Journal Article] Role of p38MAPK in the cardioprotective effect of milrinone against myocardial stunning in swine2007

    • Author(s)
      Osamu Yoshitomi
    • Journal Title

      Anesthesiology 107

    • NAID

      40021157468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390406
  • [Journal Article] Role of p38MAPK in the cardioprotective effect of milrinone against myocardial stunning in swine.2007

    • Author(s)
      Osamu Yoshitomi
    • Journal Title

      Anesthesiology 107

      Pages: 626-626

    • NAID

      40021157468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Journal Article] Role of p38 MAPK in the cardioprotective effect of milrinone against myocardial stunning in swine.2007

    • Author(s)
      Yoshitomi O, Hara T, Shibata I, Cho S, Sumikawa K
    • Journal Title

      Anesthesiology 107

    • NAID

      40021157468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Journal Article] Role of p38 MAPK in the cardioprotective effect of milrinone against myocardial stunning in swine.2007

    • Author(s)
      Yoshitomi O, Hara T, Shibata I, Cho S, Sumikawa K
    • Journal Title

      Anesthesiology 107

    • NAID

      40021157468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390406
  • [Journal Article] Cardioprotective effects of colforsin daropate hydrochloride on stunned myocardium in anesthetized pigs.2006

    • Author(s)
      Yoshitomi O, 他 4 名
    • Journal Title

      Anesthesiology 105

    • Data Source
      KAKENHI-PROJECT-18791086
  • [Journal Article] Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine.2006

    • Author(s)
      Use T, Makita T, Ureshino H, Cho S, Yoshitomi O, Akiyama D, Oshibuchi M, Hara T, Sumikawa K
    • Journal Title

      Cardiovascular Drugs and Therapy 20

      Pages: 327-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Journal Article] Cardioprotective effects of colforsin daropate hydrochloride on stunned myocardium in pigs.2006

    • Author(s)
      Yoshitomi O, Hara T, Shibata I, Akiyama D, Sumikawa K
    • Journal Title

      Anesthesiology 105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Journal Article] Fasudil-administered before or after ischemia protects stunned myocardial stunning in swine.2006

    • Author(s)
      Shibata I, Yoshitomi O, 他 3 名
    • Journal Title

      Anesthesiology 105

    • Data Source
      KAKENHI-PROJECT-18791086
  • [Journal Article] Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine.2006

    • Author(s)
      Use T, Yoshitomi O, 他 7 名
    • Journal Title

      Cardiovasc Drugs Ther 20

      Pages: 327-334

    • Data Source
      KAKENHI-PROJECT-18791086
  • [Presentation] 蘇生後心筋障害に対するデクスメデトミジンの効果―豚の心肺蘇生モデルを用いた検討―2021

    • Author(s)
      吉富 修、新谷亮祐、飛永祥平、一ノ宮大雅、原 哲也
    • Organizer
      日本循環制御医学会
    • Data Source
      KAKENHI-PROJECT-18K08921
  • [Presentation] セボフルランのコンディショニングによる肝虚血再灌流障害の軽減にはヘムオキシゲナーゼ-1が関与する2017

    • Author(s)
      白石 早紀、田中 達士、穐山 大治、柴田 伊津子、吉富 修、原 哲也
    • Organizer
      日本麻酔科学会第64回学術集会
    • Data Source
      KAKENHI-PROJECT-26462363
  • [Presentation] 心室細動を来した術中急性冠症候群の1例2012

    • Author(s)
      吉富 修
    • Organizer
      日本蘇生学会
    • Place of Presentation
      大津
    • Data Source
      KAKENHI-PROJECT-22591738
  • [Presentation] 心・大血管手術後の難治性頻脈に関わる因子について-塩酸ランジオロール使用量からの検討-2011

    • Author(s)
      吉富 修
    • Organizer
      日本集中治療医学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22591738
  • [Presentation] 血液型不適合生体肝移植後に血栓性微小血管障害(thrombotic microangiopathy: TMA)を発症した1例2010

    • Author(s)
      吉富 修
    • Organizer
      日本集中治療医学会学術集会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-22591738
  • [Presentation] 塩酸ランジオロールを使用した心・大血管手術後症例の検討2010

    • Author(s)
      吉富 修
    • Organizer
      長崎周術期管理研究会
    • Place of Presentation
      長崎
    • Data Source
      KAKENHI-PROJECT-22591738
  • [Presentation] 低心機能患者の心・大血管手術後心房細動に対する低用量塩酸ランジオロールの効果2008

    • Author(s)
      吉富修
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-08-17
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Presentation] 心筋スタニングに対するミルリノンの保護作用におけるp38MAPKの役割2007

    • Author(s)
      吉富修
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Presentation] Role of p38 MAPK in the cardioprotective effect of milrinone against myocardial stunning in swine.2007

    • Author(s)
      Yoshitomi O
    • Organizer
      ASA
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Presentation] 心筋スタニングに対するミルリノンの保護作用におけるp38MAPKの役割2007

    • Author(s)
      吉富 修
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Presentation] Cardioprotective effects of colforsin daropate hydrochloride on stunned myocardium in pigs.2006

    • Author(s)
      Yoshitomi O
    • Organizer
      ASA
    • Place of Presentation
      Chicago
    • Year and Date
      2006-10-14
    • Data Source
      KAKENHI-PROJECT-18791086
  • [Presentation] 塩酸コルホルシンダロパートの虚血前投与が心筋スタニングからの回復に与える影響2006

    • Author(s)
      吉富修
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      神戸
    • Year and Date
      2006-06-02
    • Data Source
      KAKENHI-PROJECT-18791086
  • 1.  関野 元裕 (40380927)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 2.  Ishizaki HIronori (60368941)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  SUMIKAWA Koji (60028660)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 4.  CHO Sungsam (90325655)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 5.  MIYOSHI Hiroshi (90332858)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  一ノ宮 大雅 (50404249)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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