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Kagabu Masahiro  利部 正裕

Researcher Number 30382609
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-0926-1015
Affiliation (Current) 2025: 岩手医科大学, 医学部, 特任准教授
Affiliation (based on the past Project Information) *help 2023 – 2025: 岩手医科大学, 医学部, 特任准教授
2020 – 2022: 岩手医科大学, 医学部, 講師
2018 – 2019: 岩手医科大学, 医学部, 特任講師
2016 – 2017: 岩手医科大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology
Except Principal Investigator
Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology
Keywords
Principal Investigator
腫瘍浸潤リンパ球 / 腫瘍溶解性ヘルペスウイルス / 腫瘍免疫 / 腫瘍溶解性ウイルス / 子宮癌肉腫 / ウイルス療法 / 腫瘍免疫学 / 婦人科腫瘍学 / T細胞共刺激分子 / 子宮頸がん … More / 卵巣がん / 免疫チェックポイント阻害薬 / 子宮頸癌 / 卵巣癌 … More
Except Principal Investigator
卵巣癌 / 明細胞癌 / 子宮体癌 / バイオマーカー / 卵巣明細胞癌 / HSP / p53abn / MDSC / リンパ球 / 腫瘍微小環境 / マウスモデル / 局所免疫 / 漿液性癌 / NEFH / 治療標的 / KANK1 / 卵巣がん / シスプラチン / Aurora kinase A Less
  • Research Projects

    (8 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (28 People)
  •  免疫チェックポイント阻害薬抵抗性子宮頸がんに対するウイルス療法の開発Principal Investigator

    • Principal Investigator
      利部 正裕
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Iwate Medical University
  •  Integrating precision medicine for p53abn endometrial cancer

    • Principal Investigator
      馬場 長
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Iwate Medical University
  •  卵巣明細胞癌に対するHSF1経路を標的とした新規治療法の開発

    • Principal Investigator
      板持 広明
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Iwate Medical University
  •  子宮癌肉腫に対する免疫逃避改善を誘導するウイルス療法の開発Principal Investigator

    • Principal Investigator
      利部 正裕
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Iwate Medical University
  •  Development of tumor-host integrative therapies to overcome the refractory nature of uterine serous carcinoma

    • Principal Investigator
      Baba Tsukasa
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Iwate Medical University
  •  The NEFH pathway may be a novel therapeutic target for ovarian clear cell carcinoma

    • Principal Investigator
      ITAMOCHI Hiroaki
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Iwate Medical University
  •  The KANK1 pathway may be a novel therapeutic target for ovarian clear cell carcinoma

    • Principal Investigator
      ITAMOCHI Hiroaki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Iwate Medical University
  •  Development of new viral therapy for improvement of immune escape mechanism in ovarian cancerPrincipal Investigator

    • Principal Investigator
      Kagabu Masahiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Iwate Medical University

All 2024 2023 2022 2021 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] A single-institution retrospective exploratory analysis on the effectiveness and safety of lenvatinib plus pembrolizumab for advanced endometrial cancer: insights from ProMisE molecular classification system2024

    • Author(s)
      Chiba Yohei、Kagabu Masahiro、Osakabe Mitsumasa、Ito Rikako、Sato Sho、Takatori Eriko、Kaido Yoshitaka、Nagasawa Takayuki、Shoji Tadahiro、Yanagawa Naoki、Baba Tsukasa
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 54 Issue: 4 Pages: 424-433

    • DOI

      10.1093/jjco/hyad192

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09548
  • [Journal Article] SLFN11 is a <i>BRCA</i> Independent Biomarker for the Response to Platinum-Based Chemotherapy in High-Grade Serous Ovarian Cancer and Clear Cell Ovarian Carcinoma2023

    • Author(s)
      Akashi Hidehiko、Yachida Nozomi、Ueda Haruka、Yamaguchi Manako、Yamawaki Kaoru、Tamura Ryo、Suda Kazuaki、Ishiguro Tatsuya、Adachi Sosuke、Nagase Yoshikazu、Ueda Yutaka、Ueda Masashi、Abiko Kaoru、Kagabu Masahiro、Baba Tsukasa、Nakaoka Hirofumi、Enomoto Takayuki、Murai Junko、Yoshihara Kosuke
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 23 Issue: 1 Pages: 106-116

    • DOI

      10.1158/1535-7163.mct-23-0257

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16431, KAKENHI-PROJECT-22K09635, KAKENHI-PROJECT-23K08794, KAKENHI-PROJECT-23K08859, KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-21K16810, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K27447, KAKENHI-PROJECT-23K27459
  • [Journal Article] Ovarian serous borderline tumors with recurrent or extraovarian lesions: a Japanese, retrospective, multi-institutional, population-based study2023

    • Author(s)
      Baba Tsukasa、Koshiyama Masafumi、Kagabu Masahiro、Mikami Yoshiki、Minamiguchi Sachiko、Moritani Suzuko、Ishikawa Mitsuya、Okamoto Aikou、Terao Yasuhisa、Nakanishi Toru、Katabuchi Hidetaka、Tokunaga Hideki、Satoh Toyomi、Konishi Ikuo、Yaegashi Nobuo
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 28 Issue: 10 Pages: 1411-1420

    • DOI

      10.1007/s10147-023-02393-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09548
  • [Journal Article] A Phase II Study of S-1 plus Oxaliplatin for Patients with Recurrent Non-Squamous Cell Carcinoma of the Uterine Cervix (Tohoku Gynecologic Cancer Unit: TGCU206 Study)2023

    • Author(s)
      Nagasawa Takayuki、Shoji Tadahiro、Takatori Eriko、Kaido Yoshitaka、Kagabu Masahiro、Shimizu Dai、Shigeto Tatsuhiko、Baba Tsukasa、Sugiyama Toru、Yokoyama Yoshihito
    • Journal Title

      Cancers

      Volume: 15 Issue: 21 Pages: 5201-5201

    • DOI

      10.3390/cancers15215201

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09548
  • [Journal Article] Efficacy and Safety of Platinum-based Chemotherapy with Bevacizumab Followed by Bevacizumab Maintenance for Recurrent Ovarian, Fallopian Tube or Primary Peritoneal Cancer During PARP Inhibitor Therapy: A Multicenter Retrospective Study.2023

    • Author(s)
      Abe M, Shoji T, Chiba Y, Takatori E, Kaido Y, Nagasawa T, Kagabu M, Takahashi F, Aida T, Baba T.
    • Journal Title

      Anticancer Res

      Volume: 43(3) Issue: 3 Pages: 1265-1272

    • DOI

      10.21873/anticanres.16273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09548
  • [Journal Article] Treatment of HPV-related uterine cervical cancer with a third-generation oncolytic herpes simplex virus in combination with an immune checkpoint inhibitor.2023

    • Author(s)
      Kagabu M, Yoshino N, Murakami K, Kawamura H, Sasaki Y, Muraki Y, Baba T.
    • Journal Title

      Int J Mol Sci.

      Volume: 24(3) Issue: 3 Pages: 1988-1988

    • DOI

      10.3390/ijms24031988

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08511, KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-22K09602
  • [Journal Article] Comparison of treatment outcomes between first-line chemotherapy with or without bevacizumab for advanced ovarian, fallopian tube, and primary peritoneal cancer (Tohoku gynecologic cancer unit: TGCU-RS001 study)2022

    • Author(s)
      Takatori E, Nagasawa T, Kagabu M, Baba T, Shigeto T, Matsumura Y, Shimizu D, Terada Y, Seino M, Ohta T, Nagase S, Shigeta S, Tokunaga H, Shimada M, Kaiho-Sakuma M, Furukawa S, Soeda S, Watanabe T, Takahashi F, Yokoyama Y.
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 27 Issue: 12 Pages: 1874-1880

    • DOI

      10.1007/s10147-022-02246-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09531, KAKENHI-PROJECT-21K09548
  • [Journal Article] Sentinel node navigation surgery in cervical cancer: a systematic review and metaanalysis.2022

    • Author(s)
      Chiyoda T, Yoshihara K, Kagabu M, Nagase S, Katabuchi H, Mikami M, Tabata T, Hirashima Y, Kobayashi Y, Kaneuchi M, Tokunaga H, Baba T
    • Journal Title

      Int J Clin Oncol.

      Volume: 27(8) Issue: 8 Pages: 1247-1255

    • DOI

      10.1007/s10147-022-02178-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-22K09635, KAKENHI-PROJECT-22H04923
  • [Journal Article] Efficacy and Safety of Platinum Rechallenge in Patients With Platinum-resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer: A Multicenter Retrospective Study.2022

    • Author(s)
      Tatsuki S, Shoji T, Abe M, Tomabechi H, Takatori E, Kaido Y, Nagasawa T, Kagabu M, Aida T, Baba T.
    • Journal Title

      Anticancer Res.

      Volume: 42(9) Issue: 9 Pages: 4603-4610

    • DOI

      10.21873/anticanres.15964

    • Data Source
      KAKENHI-PROJECT-21K09548
  • [Journal Article] Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells.2022

    • Author(s)
      Mise Y, Hamanishi J, Daikoku T, Takamatsu S, Miyamoto T, Taki M, Yamanoi K, Yamaguchi K, Ukita M, Horikawa N, Abiko K, Murakami R, Furutake Y, Hosoe Y, Terakawa J, Kagabu M, Sugai T, Osakabe M, Fujiwara H, Matsumura N, Mandai M, Baba T.
    • Journal Title

      Carcinogenesis

      Volume: na Issue: 7 Pages: 647-658

    • DOI

      10.1093/carcin/bgac032

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09287, KAKENHI-PROJECT-18H02947, KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-20K16431, KAKENHI-PROJECT-21K09512, KAKENHI-PROJECT-21J15178, KAKENHI-PROJECT-20K07412
  • [Journal Article] Novel therapeutic strategies for refractory ovarian cancers: Clear cell and mucinous carcinomas.2021

    • Author(s)
      Shoji T, Tatsuki S, Abe M, Tomabechi H, Takatori E, Kaido Y, Nagasawa T, Kagabu M, Baba T, Itamochi H.
    • Journal Title

      Cancers

      Volume: 13 Issue: 23 Pages: 6120-6120

    • DOI

      10.3390/cancers13236120

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09759
  • [Journal Article] Comparison of Postoperative Adjuvant Chemotherapy and Concurrent Chemoradiotherapy for FIGO2018 Stage IIIC1 Cervical Cancer: A Retrospective Study2021

    • Author(s)
      Kagabu Masahiro、Nagasawa Takayuki、Tatsuki Shunsuke、Fukagawa Yasuko、Tomabechi Hidetoshi、Takatori Eriko、Kaido Yoshitaka、Shoji Tadahiro、Baba Tsukasa
    • Journal Title

      Medicina

      Volume: 57 Issue: 6 Pages: 548-548

    • DOI

      10.3390/medicina57060548

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09548
  • [Journal Article] Mast cells partially contribute to mucosal adjuvanticity of surfactin in mice.2018

    • Author(s)
      Yoshino N, Takeshita R, Kawamura H, Sasaki Y, Kagabu M, Sugiyama T, Muraki Y, Sato S.
    • Journal Title

      Immun Inflamm Dis.

      Volume: 6 Issue: 1 Pages: 117-127

    • DOI

      10.1002/iid3.204

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Journal Article] Critical micelle concentration and particle size determine adjuvanticity of cyclic lipopeptides2018

    • Author(s)
      Yoshino N, Takeshita R, Kawamura H, Murakami K, Sasaki Y, Sugiyama I, Sadzuka Y, Kagabu M, Sugiyama T, Muraki Y, Sato S.
    • Journal Title

      Scandinavian Journal of Immunology

      Volume: 88 Issue: 2

    • DOI

      10.1111/sji.12698

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08445, KAKENHI-PROJECT-16K15711
  • [Journal Article] The efficacy of oncolytic herpes simplex viral therapy for uterine cervical cancer2018

    • Author(s)
      Masahiro Kagabu, Naoto Yoshino, Tatsunori Saito, Yuki Miura, Ryosuke Takeshita, Kazuyuki Murakami, Hideki Kawamura, Tsukasa Baba, Toru Sugiyama
    • Journal Title

      OncoTargets and Therapy(under review)

      Volume: -

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Journal Article] 腫瘍溶解性ヘルペスウイルスとシクロホスファミドを併用した 子宮頸がん新規治療法の検討2017

    • Author(s)
      川村 英生,利部 正裕,佐々木 裕,村上 一行, 川村 花恵,池田 浩,阿保 亜希子, 吉野 直人,村木 靖,杉山 徹
    • Journal Title

      岩手医学会雑誌

      Volume: 69

    • NAID

      40021252419

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Journal Article] 腫瘍溶解性ヘルペスウイルスとシクロホスファミドを併用した 子宮頸がん新規治療法の検討2017

    • Author(s)
      川村 英生,利部 正裕,佐々木 裕,村上 一行, 川村 花恵, 池田 浩,阿保 亜希子, 吉野 直人,村木 靖,杉山 徹
    • Journal Title

      岩手医学会雑誌

      Volume: 69 Pages: 75-88

    • NAID

      40021252419

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Journal Article] 腫瘍溶解性ウイルスと免疫チェックポイント阻害剤を併用した子宮頸がんに対する新規治療法の検討2016

    • Author(s)
      村上 一行,利部 正裕,佐々木 裕,川村 花恵, 川村 英生,吉野 直人,村木 靖,杉山 徹
    • Journal Title

      岩手医学会雑誌

      Volume: 68 Pages: 113-130

    • NAID

      40020971476

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Presentation] Efficacy of combination chemotherapy and third-generation oncolytic herpes virus therapy for Cervical Cancer2023

    • Author(s)
      Masahiro Kagabu, Hideki Kawamura, Kazuyuki Murakami, Hanae Kawamura, Naoto Yoshino, Yasushi Muraki and Tsukasa Baba
    • Organizer
      International Gynecologic Cancer Society Annual Global Meeting 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09602
  • [Presentation] 子宮頸がん検診によって発見された子宮頸部腺癌の検討2018

    • Author(s)
      利部正裕
    • Organizer
      日本臨床細胞学会総会
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Presentation] 癌治療におけるCART 婦人科悪性腫瘍患者におけるCART療法2018

    • Author(s)
      利部正裕
    • Organizer
      日本アフェレシス学会学術講演会
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Presentation] 子宮頸がんに対する腫瘍溶解性ウイルスと免疫チェックポイント阻害剤を併用した新規療法の検討2017

    • Author(s)
      村上 一行,利部 正裕,佐々木 裕,川村 花恵, 川村 英生,吉野 直人,村木 靖,杉山 徹
    • Organizer
      第34回日本産婦人科感染症学会・学術集会
    • Place of Presentation
      奈良春日野国際フォーラム(奈良)
    • Year and Date
      2017-05-20
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Presentation] 子宮頸がんに対する腫瘍溶解性ウイルスと免疫チェックポイント阻害剤を併用した新規療 法の検討2017

    • Author(s)
      村上 一行,利部 正裕,佐々木 裕,川村 花恵, 川村 英生, 吉野 直人,村木 靖,杉山 徹
    • Organizer
      第34回日本産婦人科感染症学会・学術集会
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Presentation] 子宮頸がんに対する化学療法とウイルス併用療法への基礎研究2017

    • Author(s)
      川村 英生, 利部 正裕, 村上 一行, 川村 花恵, 板持 広明, 杉山 徹
    • Organizer
      第68回日本産科婦人科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Presentation] 腫瘍溶解性ウイルスと化学療法を併用した子宮頸がん新規治療法の検討2017

    • Author(s)
      川村 英生,利部 正裕,佐々木 裕,村上 一行, 川村 花恵, 池田 浩,阿保 亜希子, 吉野 直人,村木 靖,杉山 徹
    • Organizer
      第34回日本産婦人科感染症学会・学術集会
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Presentation] Aurora-A inhibition synergistically enhances cisplatin induced cytotoxicity in ovarian clear cell carcinoma cell lines.2017

    • Author(s)
      Chiba Y, Sato S, Fukagawa D, Suga Y, Kagabu M, Chiba A, Takeuchi S, Itamochi H, Sugai T, Sugiyama T.
    • Organizer
      5th Biennial Meeting of Asian Society of Gynecologic Oncology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11151
  • [Presentation] 腫瘍溶解性ウイルスと化学療法を併用した子宮頸がん新規治療法の検討2017

    • Author(s)
      川村 英生,利部 正裕,佐々木 裕,村上 一行, 川村 花恵,池田 浩,阿保 亜希子, 吉野 直人,村木 靖,杉山 徹
    • Organizer
      第34回日本産婦人科感染症学会・学術集会
    • Place of Presentation
      奈良春日野国際フォーラム(奈良)
    • Year and Date
      2017-05-20
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Presentation] 子宮頸がんに対する単純ヘルペスウイルスを用いたウイルス療法と抗がん剤併用療法における基礎研究2016

    • Author(s)
      川村 英生, 利部 正裕, 村上 一行, 佐々木 裕, 川村 花恵, 吉野 直人, 村木 靖, 杉山 徹
    • Organizer
      第64回北日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-16K15711
  • [Presentation] 子宮頸がんに対する腫瘍溶解性ウイルスと免疫チェックポイント阻害剤療法についての検討2016

    • Author(s)
      村上 一行,利部 正裕,川村 花恵,川村 英生,杉山 徹
    • Organizer
      第68回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-16K15711
  • 1.  Baba Tsukasa (60508240)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 10 results
  • 2.  ITAMOCHI Hiroaki (20314601)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 3.  永沢 崇幸 (10453309)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 4.  佐藤 誠也 (30621007)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  杉山 徹 (40162903)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 6.  小島 淳美 (60508753)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  庄子 忠宏 (00337148)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 8.  大黒 多希子 (30767249)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  濱西 潤三 (80378736)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
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  • 27.  安彦 郁
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  • 28.  村上 隆介
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