HOSAKA Naoki 保坂直樹

… Alternative Names

保坂直樹ホサカナオキ

保阪直樹ホサカナオキ

Less

Researcher Number	30388459
Other IDs
Affiliation (Current)	2025: 関西医科大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help	2024: 関西医科大学, 医学部, 研究員 2017 – 2022: 関西医科大学, 医学部, 研究員 2011 – 2016: 関西医科大学, 医学部, 講師 2004: Kansai Medical University, Faculty of Medicine, Assistant Prof, 医学部, 講師
Review Section/Research Field	Principal Investigator Experimental pathology / Basic Section 49030:Experimental pathology-related Except Principal Investigator Laboratory medicine / Cerebral neurosurgery / Gastroenterology
Keywords	Principal Investigator 胸腺 / γδT細胞 / T細胞 / 再生 / 癌免疫療法 / CD8T細胞 / 移植 / 胸腺移植 / 骨髄移植 / 細胞融合 / 胸腺上皮細胞 … More Except Principal Investigator … More bone marrow / differentiation / transplantation / stem cell / 脂肪分解酵素 / 高血圧 / 内因性ジギタリス / HPLC / ELISA / エステラーゼ / マリノブフォトキシン / マリノブファゲニン / 内因性ジギタリス様物質 / f regeneration / flow cytometry / ischemic brain / Regeneration / regeneration / bone marroew / 神経シグナル / 腸上皮幹細胞 / 神経細胞 / 血管作動性腸管ペプチド / 小腸上皮幹細胞 / オルガノイド / 神経線維 / VIP / 神経伝達物質 / パネート細胞 / 上皮幹細胞 / 小腸 Less

Ex vivoでのCD8T細胞の誘導・増殖法の開発　-免疫チェックポイント療法の増強と制御-Principal Investigator
- Principal Investigator
  
  保坂直樹
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kansai Medical University
再生胸腺微小環境によるT細胞の誘導　　―γδT細胞の産生と悪性腫瘍への応用―Principal Investigator
- Principal Investigator
  
  保坂直樹
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kansai Medical University
Induction of T cells by regenerative thymic microenviroment and the application for therapyPrincipal Investigator
- Principal Investigator
  
  HOSAKA Naoki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kansai Medical University
Mechanism of production, secretion and hypertension in the endogenous digitalis like factors mediating lipolytic enzyme
- Principal Investigator
  
  YOSHIKA Masamichi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kansai Medical University
Treatment of cancer by a new BMT method using co-transplantation of regenerated thymusPrincipal Investigator
- Principal Investigator
  
  HOSAKA Naoki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kansai Medical University
Analysis of three dimensional architecture of thymic epithelial cells by the multicolor lineage tracing methodPrincipal Investigator
- Principal Investigator
  
  HOSAKA Naoki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kansai Medical University
Examination of neuroregulation in intestinal epithelium using stem cell differentiation-visualizing mice
- Principal Investigator
  
  HISHA Hiroko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kansai Medical University
Study for neuronal regeneration in ischemic brain using bone marrow transplantation
- Principal Investigator
  
  KAWAMOTO Keiji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kansai Medical University

All 2022 2021 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Induction of γδT cells from HSC‐enriched BMCs co‐cultured with iPSC‐derived thymic epithelial cells2021
- Author(s)
  Hosaka Naoki、Kanda Seiji、Shimono Takaki、Nishiyama Toshimasa
- Journal Title
  
  Journal of Cellular and Molecular Medicine
  
  Volume: 25 Issue: 22 Pages: 10604-10613
- DOI
  10.1111/jcmm.16993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06977
[Journal Article] 胸腺移植併用による新しいアロ造血幹細胞移植法の開発-その機構と難治性疾患への応用-2014
- Author(s)
  保坂直樹
- Journal Title
  
  日臨免疫会誌
  
  Volume: 37巻 Pages: 42-47
- NAID
  130003391982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590479
[Journal Article] New allogeneic hematopoietic stem cell transplantation method : hematopoietic stem cell transplantation plus thymus transplantation for intractable diseases2013
- Author(s)
  Hosaka N
- Journal Title
  
  Clin Dev Immunol
  
  Volume: 2013 Pages: 1-7
- DOI
  10.1155/2013/545621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590479
[Journal Article] Progressive thoracic myelopathy caused by spinal calcium pyrophosphate crystal deposition because of proximal junctional vertebral compression fracture after lumbopelvic fusion2012
- Author(s)
  Odate S, Hosaka N (4名省略)
- Journal Title
  
  Eur Spine J
  
  Volume: vol.21 Pages: 2436-2442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590479
[Journal Article] Effects of Intrabone Marrow-Bone Marrow Transplantation Plus Adult Thymus Transplantation on Survival of Mice Bearing Leukemia2012
- Author(s)
  Zhang Y, Hosaka N (5名省略)
- Journal Title
  
  Stem Cells Dev
  
  Volume: vol.219 Pages: 1441-1448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590479
[Journal Article] Poorly differentiated squamous cell carcinoma of the nipple : a unique case for marked exophytic growth, but little invasion with neuroendocrine differentiation2011
- Author(s)
  Hosaka N(5名省略)
- Journal Title
  
  Med Mol Morphol
  
  Volume: vol.44 Pages: 174-178
- NAID
  10030463889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590479
[Presentation] 骨髄細胞からのγδT細胞の産生　-iPS細胞由来胸腺上皮細胞を用いて-2022
- Author(s)
  保坂直樹　神田靖士　下埜敬紀　西山利正
- Organizer
  第111回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K06977
[Presentation] Prolonged survival in mice with advanced tumors treated with intra-bone marrow BMT plus fetal thymus transplantation with restoration of T cell functions2013
- Author(s)
  Hosaka N
- Organizer
  第100回米国免疫学会
- Place of Presentation
  ホノルル
- Year and Date
  2013-05-05
- Data Source
  KAKENHI-PROJECT-23590479
[Presentation] 骨髄内骨髄移植と成体胸腺併用移植による白血病の治療II2013
- Author(s)
  保坂直樹
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Year and Date
  2013-06-07
- Data Source
  KAKENHI-PROJECT-23590479
[Presentation] Poorly differentiated squamous cell carcinoma of the nipple. A uniqu case for marked exophytic growth, but little invasion with neuroendocrine differentiation2012
- Author(s)
  Hosaka N
- Organizer
  The 12th Asia Society of clinical Pathology and Laboratory Medicine (ASCPaLM)
- Place of Presentation
  京都
- Year and Date
  2012-12-01
- Data Source
  KAKENHI-PROJECT-23590479
[Presentation] Effects of Allogenic Intrabone Marrow-Bone Marrow Transplantation Plus Adult Thymus Transplantation on Mice Bearing Leukemia2012
- Author(s)
  Hosaka N
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23590479
[Presentation] 胸腺移植を併用した新しい骨髄移植法の悪性腫瘍に対する効果II:胎生、新生、成体期の造血幹細胞と胸腺の比較2012
- Author(s)
  保坂直樹
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-26
- Data Source
  KAKENHI-PROJECT-23590479
[Presentation] 神経内分泌性分化と伴に著明な外方性発育を示した乳頭扁平上皮癌の１例2011
- Author(s)
  保坂直樹
- Organizer
  第１００回日本病理学会総会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-23590953
[Presentation] Effects of IBM-BMT plus Adult Thymus Transplantation on Mice bearing Leukemia2011
- Author(s)
  Hosaka N
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-23590479

1. KANDA Akira (70375244)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
2. 神田靖士 (70295799)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. 下埜敬紀 (40632625)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
4. HISHA Hiroko (90151422)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MAKI Masahiko (80297001)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. IKEHARA Susumu (90108986)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YOSHIKA Masamichi (70434834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KAWAMOTO Keiji (70077741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YOSHIMURA Kunikazu (60298891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大江知里 (40469242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 沼義博 (40208278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 安水良知 (00142753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HOSAKA Naoki 保坂 直樹

保坂 直樹 ホサカ ナオキ

保阪 直樹 ホサカ ナオキ

Research Projects

Research Products

Co-Researchers

Ex vivoでのCD8T細胞の誘導・増殖法の開発 -免疫チェックポイント療法の増強と制御-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

再生胸腺微小環境によるT細胞の誘導 ―γδT細胞の産生と悪性腫瘍への応用―Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Induction of T cells by regenerative thymic microenviroment and the application for therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of production, secretion and hypertension in the endogenous digitalis like factors mediating lipolytic enzyme

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Treatment of cancer by a new BMT method using co-transplantation of regenerated thymusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of three dimensional architecture of thymic epithelial cells by the multicolor lineage tracing methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Examination of neuroregulation in intestinal epithelium using stem cell differentiation-visualizing mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for neuronal regeneration in ischemic brain using bone marrow transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Induction of γδT cells from HSC‐enriched BMCs co‐cultured with iPSC‐derived thymic epithelial cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 胸腺移植併用による新しいアロ造血幹細胞移植法の開発-その機構と難治性疾患への応用-2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] New allogeneic hematopoietic stem cell transplantation method : hematopoietic stem cell transplantation plus thymus transplantation for intractable diseases2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Progressive thoracic myelopathy caused by spinal calcium pyrophosphate crystal deposition because of proximal junctional vertebral compression fracture after lumbopelvic fusion2012

Author(s)

Journal Title

Data Source

[Journal Article] Effects of Intrabone Marrow-Bone Marrow Transplantation Plus Adult Thymus Transplantation on Survival of Mice Bearing Leukemia2012

Author(s)

Journal Title

Data Source

[Journal Article] Poorly differentiated squamous cell carcinoma of the nipple : a unique case for marked exophytic growth, but little invasion with neuroendocrine differentiation2011

Author(s)

Journal Title

HOSAKA Naoki 保坂直樹

保坂直樹ホサカナオキ

保阪直樹ホサカナオキ

Ex vivoでのCD8T細胞の誘導・増殖法の開発　-免疫チェックポイント療法の増強と制御-Principal Investigator

再生胸腺微小環境によるT細胞の誘導　　―γδT細胞の産生と悪性腫瘍への応用―Principal Investigator

[Presentation] 骨髄細胞からのγδT細胞の産生　-iPS細胞由来胸腺上皮細胞を用いて-2022