Hara Munetsugu 原宗嗣

… Alternative Names

原宗嗣ハラムネツグ

HARA Munetsugu 原宗嗣

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Researcher Number	30389283
Other IDs
Affiliation (Current)	2025: 久留米大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 久留米大学, 医学部, 講師 2012 – 2015: 久留米大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator レット症候群 / Rett症候群 / G欠損狂犬病ウイルストレーシング法 / 三次元画像再構築 / 分化転換 / 不整脈 / 自律神経機能障害 / 心交感神経 / MeCP2 / 心臓 / グレリン

Does neurotransmitter switch of autonomic nerve lead to disturb heart-brain interaction of Rett syndrome?Principal Investigator
- Principal Investigator
  
  原宗嗣
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
The study of impaired autonomic nerve system in Rett syndrome model mice and ES/iPS cells derived from themPrincipal Investigator
- Principal Investigator
  
  HARA MUNETSUGU
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Development of a new therapy for Rett syndrome model iPS cells and mouse by recombinant GhrelinPrincipal Investigator
- Principal Investigator
  
  HARA Munetsugu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University

All 2024 2023 2022 2021 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] 日常生活から学ぶ発達障害と睡眠2024
- Author(s)
  山下裕史郎、原宗嗣、弓削康太郎、石井隆大
- Total Pages
  272
- Publisher
  診断と治療社
- ISBN
  9784787826176
- Data Source
  KAKENHI-PROJECT-21K07858
[Journal Article] Perampanel markedly improved clinical seizures in a patient with a Rett-like phenotype and 960-kb deletion on chromosome 9q34.11 including the STXBP12022
- Author(s)
  4.Yoshida S., Amamoto M., Takahashi T., Tomita I., Yuge K., Hara M., Iwama K., Matsumoto N., Matsuishi T.
- Journal Title
  
  Clin Case Rep
  
  Volume: in press Issue: 5 Pages: 1-7
- DOI
  10.1002/ccr3.5811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08198, KAKENHI-PROJECT-18K07893, KAKENHI-PROJECT-21K07858, KAKENHI-PROJECT-22K15952
[Journal Article] Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias.2015
- Author(s)
  Hara M, Takahashi T, Mistumasu C, Igata S, Takano M, Minami T, Yasukawa H, Okayama S, Nakamura K, Okabe Y, Tanaka E, Takemura G, Kosai K, Yamashita Y, Matsuishi T.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 11204-11204
- DOI
  10.1038/srep11204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461137, KAKENHI-PROJECT-25461568, KAKENHI-PROJECT-25670194, KAKENHI-PROJECT-26670292, KAKENHI-PROJECT-26860832, KAKENHI-PROJECT-24300145, KAKENHI-PROJECT-25293234
[Journal Article] Clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination.2015
- Author(s)
  Takanashi J, Shiihara T, Hasegawa T, Takayanagi M, Hara M, Okumura A, Mizuguchi M.
- Journal Title
  
  J Neurol Sci
  
  Volume: 349(1-2) Issue: 1-2 Pages: 226-228
- DOI
  10.1016/j.jns.2014.12.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860832, KAKENHI-PROJECT-24390258
[Journal Article] De novo KCNT1 mutations in early-onset epileptic encephalopathy.2015
- Author(s)
  Ohba C, Kato M, Takahashi N, Osaka H, Shiihara T, Tohyama J, Nabatame S, Azuma J, Fujii Y, Hara M, Tsurusawa R, Inoue T, Ogata R, Watanabe Y, Togashi N, Kodera H, Nakashima M, Tsurusaki Y, Miyake N, Tanaka F, Saitsu H, Matsumoto N.
- Journal Title
  
  Epilepsia
  
  Volume: 56(9) Issue: 9
- DOI
  10.1111/epi.13072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19660, KAKENHI-PROJECT-26860816, KAKENHI-PROJECT-26860832, KAKENHI-PROJECT-25293085, KAKENHI-PROJECT-25293235
[Journal Article] De novo SHANK3 mutation causes a female patient with Rett syndrome like phenotype.2015
- Author(s)
  Hara M, Ohba C, Yamashita Y, Saitsu H, Matsumoto N, Matsuishi T.
- Journal Title
  
  J Med Genet Part A
  
  Volume: 167(7) Issue: 7 Pages: 1593-1596
- DOI
  10.1002/ajmg.a.36775
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118007, KAKENHI-PROJECT-26860832
[Journal Article] Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett Syndrome2014
- Author(s)
  Hara M, Nishi Y, Yamashita Y, Hirata R, Takahashi S, Nagamitsu S, Hosoda H, Kangawa K, Kojima M, Matsuishi T
- Journal Title
  
  Brain Dev
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791094
[Journal Article] serial 18FDG-PET study of a patient with SSPE who had good prognosis by combination therapy with interferon alpha and ribavirin2014
- Author(s)
  Ohya T, Yamashita Y, Shibuya I, Hara M, Nagamitsu S, Kaida H, Kurata S, Ishibashi M, Matsuishi T
- Journal Title
  
  Brain Dev
  
  Volume: in press Issue: 4 Pages: 41-45
- DOI
  10.1016/j.ejpn.2014.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791094, KAKENHI-PROJECT-25460643, KAKENHI-PROJECT-26860832
[Journal Article] serial 18FDG-PET study of a patient with SSPE who had good prognosis by combination therapy with interferon alpha and ribavirin2014
- Author(s)
  Ohya, T, Yamashita, Y, Shibuya, I, Hara, M, Nagamitsu, S, Kaida, H, Kurata, S, Ishibashi, M, Matsuishi, T
- Journal Title
  
  Eur J Pediatr Neurol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791094
[Journal Article] Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett syndrome2013
- Author(s)
  Hara M, Nishi Y, Yamashita Y, Hirata R, Takahashi S, Nagamitsu SI, Hosoda H, Kangawa K, Kojima M, Matsuishi T
- Journal Title
  
  Brain Dev
  
  Volume: 36 Issue: 9 Pages: 794-800
- DOI
  10.1016/j.braindev.2013.11.007
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22126003, KAKENHI-PROJECT-25460643, KAKENHI-PROJECT-25461570, KAKENHI-PROJECT-26860832
[Journal Article] An adult patient with mucolipidosis III alpha/beta presenting with parkinsonism2013
- Author(s)
  Hara M, Inokuchi T, Taniwaki T, Otomo T, Sakai N, Matsuishi T, Yoshino M
- Journal Title
  
  Brain Dev
  
  Volume: 35(5) Pages: 462-465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791094
[Journal Article] An adult patient with mucolipidosis III alpha/beta presenting with parkinsonism2013
- Author(s)
  Hara M, Inokuchi T, Taniwaki T, Otomo T, Sakai N, Matsuishi T, Yoshino M
- Journal Title
  
  Brain and Development
  
  Volume: 35 Issue: 5 Pages: 462-465
- DOI
  10.1016/j.braindev.2012.07.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591306, KAKENHI-PROJECT-24591531, KAKENHI-PROJECT-24791094
[Journal Article] Eyelid myoclonia with absences occurring during the clinical course of cryptogenic myoclonic epilepsy of early childhood2012
- Author(s)
  Ohya T, Yamashita Y, Shibuya I, Hara M, Nagamitsu S, Matsuishi T
- Journal Title
  
  Eur J Paediatr Neurol
  
  Volume: 16(4) Pages: 399-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791094
[Journal Article] Prefrontal brain function in children with anorexia nervosa : a near-infrared spectroscopy study2011
- Author(s)
  Nagamitsu S, Araki Y, Ioji T, Yamashita F, Ozono S, Kouno M, Iizuka C, Hara M, Shibuya I, Ohya T, Yamashita Y, Tsuda A, Kakuma T, Matsuishi T
- Journal Title
  
  Brain Dev
  
  Volume: 33(1) Pages: 35-44
- NAID
  10029560112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791094
[Journal Article] A case of clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination2011
- Author(s)
  Hara M, Mizuochi T, Kawano G, Koike T, Shibuya I, Ohya T, Ohbu K, Nagai K, Nagamitsu S, Yamashita Y, Nakayama T, Matsuishi T
- Journal Title
  
  Brain Dev
  
  Volume: 33(10) Pages: 842-4
- NAID
  10031122000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791094
[Journal Article] Eyelid myoclonia with absences occurring during the clinical course of cryptogenic myoclonic epilepsy of early childhood2011
- Author(s)
  Ohya T, Yamashita Y, …, Matsuishi T
- Journal Title
  
  Eur J Paediat Neurol
  
  Volume: 16 Issue: 4 Pages: 399-401
- DOI
  10.1016/j.ejpn.2011.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591338, KAKENHI-PROJECT-22591143, KAKENHI-PROJECT-24591531, KAKENHI-PROJECT-24791094
[Journal Article] Ghrelin levels are reduced in Rett syndrome patients with eating difficulties2011
- Author(s)
  Hara M, Nishi Y, Yamashita Y, Yoh J, Takahashi S, Nagamitsu S, Kakuma T, Hosoda H, Kangawa K, Kojima M, Matsuishi T
- Journal Title
  
  Int J Devl Neuroscience
  
  Volume: 29(8) Pages: 899-902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] 繰り返す熱性けいれんからミオクロニー欠伸てんかんへ移行した1q44微小欠失症候群の一例．2023
- Author(s)
  原宗嗣，福井香織，高瀬隆太，渡邊順子，山下裕史朗
- Organizer
  第45回日本小児遺伝学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07858
[Presentation] West症候群における10年間の質量分析による尿中、血中メタボローム解析2023
- Author(s)
  小池敬義，山下大輔，吉塚悌子，石井隆大，弓削康太郎，原宗嗣，田代恭子，渡邊順子，山下裕史朗
- Organizer
  第65回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07858
[Presentation] 当院における結節性硬化症の画像タイプ別の検証2023
- Author(s)
  石井隆大，山下大輔，弓削康太郎，小池敬義，原宗嗣，山下裕史朗
- Organizer
  第65回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07858
[Presentation] 重度側弯があるにもかかわらず治療薬をrisdiplamからnusinersenへ戻した脊髄性筋萎縮症２型の成人例2023
- Author(s)
  弓削康太郎，山下大輔，八戸由佳子，石井隆大，小池敬義，原宗嗣，山下裕史朗
- Organizer
  第65回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07858
[Presentation] 右内斜視を契機に脳動脈瘤の診断に至った結節性硬化症の4歳男児2023
- Author(s)
  阪田健佑，山下大輔，石井隆大，弓削康太郎，小池敬義，原宗嗣，音琴哲也，森岡基浩, 山下裕史朗
- Organizer
  第65回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07858
[Presentation] 達遅延、小脳症状を認めた10歳男児2021
- Author(s)
  1.後藤康平，八戸由佳子，石井隆大，磯岡藍子，七種朋子，弓削康太郎，岡部留美子，原　宗嗣，大矢崇志，家村明子，永光信一郎，山下裕史朗
- Organizer
  第90回日本小児神経学会九州地方会
- Data Source
  KAKENHI-PROJECT-21K07858
[Presentation] 周期性嘔吐症を発症した精神遅滞, 自閉症を有する奇形症候群の1 例2013
- Author(s)
  齊木玲央, 原宗嗣, 今城透, 澁谷郁彦, 大矢崇志, 永光信一郎, 山下裕史朗, 松石豊次郎
- Organizer
  第55回日本小児神経学会学術集会
- Place of Presentation
  大分
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] 生後発達に伴うマウス脳内でのグレリン含量の変動に関する検討2013
- Author(s)
  平田留美子, 西芳寛, 御船弘治, 細田洋司, 寒川賢治, 児島将康, 田中永一郎, 原宗嗣, 山下裕史朗, 松石豊次郎
- Organizer
  第116回日本小児科学会学術総会
- Place of Presentation
  広島
- Year and Date
  2013-04-19
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] 周期性嘔吐症を発症した精神遅滞、自閉症を有する奇形症候群の1例2013
- Author(s)
  齊木玲央、原宗嗣、今城透、澁谷郁彦、大矢崇志、永光信一郎、山下裕史朗、松石豊次郎
- Organizer
  第55回日本小児神経学会学術集会
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] 脳葉切除を行った側頭葉てんかん症例における脳血流の検討2012
- Author(s)
  大矢崇志, 澁谷郁彦, 原宗嗣, 永光信一郎, 山下裕史朗, 松石豊次郎
- Organizer
  第115回日本小児科学学術集会
- Place of Presentation
  福岡
- Year and Date
  2012-04-20
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] Plasma ghrelin and serum IGF-1 in patients with Rett syndrome and its relationship to the head growth.2012
- Author(s)
  Hara M, Nishi Y, Yoh J, Takahashi S, Yamashita Y, Hosoda H, Kangawa K, Kojima M, Matsuishi T.
- Organizer
  The 12th International Child Neurology Congress and the 11th Asia and Ocesnian Congress of Child Neurology 2012
- Place of Presentation
  Brisbane, Australia
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] Plasma ghrelin and serum IGF-1 in patients with Rett syndrome and its relationship to the head growth2012
- Author(s)
  Hara M, Nishi Y, Yoh J, Takahashi S, Yamashita Y, Hosoda H, Kangawa K, Kojima M, Matsuishi T
- Organizer
  The 12th International Child Neurology Congress and the 11th Asia and Oceanian Congress of Child Neurology 2012
- Place of Presentation
  Brisbane, Australia
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] 無症候性先天性サイトメガロウイルス感染症4 例の臨床的検討2012
- Author(s)
  澁谷郁彦, 大矢崇志, 後藤憲次, 原宗嗣, 永光信一郎, 山下裕史朗, 松石豊次郎
- Organizer
  第115回日本小児科学学術集会
- Place of Presentation
  福岡
- Year and Date
  2012-04-21
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] Plasma concentration of ghrelin in patients with Rett syndrome together with their relationship to clinical manifestations2011
- Author(s)
  Nishi Y, Hara M, Matsuishi T
- Organizer
  第84回日本内分泌学会総会
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] Mecp2 遺伝子変異をもつレット症候群患者の血漿中グレリン濃度の検討2011
- Author(s)
  原宗嗣, 西芳寛, 山下裕史朗, 松石豊次郎
- Organizer
  第53回日本小児神経学会総会
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] 無症候性先天性サイトメガロウイルス感染症4例の臨床的検討
- Author(s)
  澁谷郁彦,大矢崇志,後藤憲次,原宗嗣,永光信一郎,山下裕史朗,松石豊次郎
- Organizer
  第115回日本小児科学学術集会
- Place of Presentation
  福岡、日本
- Data Source
  KAKENHI-PROJECT-24791094
[Presentation] Analysis of cardiac arrthymias and gene expression in MeCP2-null mice.
- Author(s)
  Hara M, Takahashi T, Mitsumasu C, Igata S, Takano M, Okabe Y, Tanaka E, Matsuishi T.
- Organizer
  13th Rett syndrome Symposium.
- Place of Presentation
  Chantilly, VA, USA.
- Year and Date
  2014-06-24 – 2014-06-26
- Data Source
  KAKENHI-PROJECT-26860832
[Presentation] 脳葉切除を行った側頭葉てんかん症例における脳血流の検討
- Author(s)
  大矢崇志,澁谷郁彦,原宗嗣,永光信一郎,山下裕史朗,松石豊次郎
- Organizer
  第115回日本小児科学学術集会
- Place of Presentation
  福岡、日本
- Data Source
  KAKENHI-PROJECT-24791094

1. 高橋知之 (20332687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 弓削康太郎 (20624472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. 松石豊次郎 (60157237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 山下裕史朗 (90211630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. ISHI Shunsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 高橋和之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 安川秀雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 鶴崎美徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 児島将康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 松本直通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 谷脇考恭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Munetsugu 原 宗嗣

原 宗嗣 ハラ ムネツグ

HARA Munetsugu 原 宗嗣

Research Projects

Research Products

Co-Researchers

Does neurotransmitter switch of autonomic nerve lead to disturb heart-brain interaction of Rett syndrome?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study of impaired autonomic nerve system in Rett syndrome model mice and ES/iPS cells derived from themPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new therapy for Rett syndrome model iPS cells and mouse by recombinant GhrelinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 日常生活から学ぶ発達障害と睡眠2024

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Perampanel markedly improved clinical seizures in a patient with a Rett-like phenotype and 960-kb deletion on chromosome 9q34.11 including the STXBP12022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] De novo KCNT1 mutations in early-onset epileptic encephalopathy.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] De novo SHANK3 mutation causes a female patient with Rett syndrome like phenotype.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett Syndrome2014

Author(s)

Journal Title

Data Source

[Journal Article] serial 18FDG-PET study of a patient with SSPE who had good prognosis by combination therapy with interferon alpha and ribavirin2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] serial 18FDG-PET study of a patient with SSPE who had good prognosis by combination therapy with interferon alpha and ribavirin2014

Author(s)

Journal Title

Data Source

[Journal Article] Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett syndrome2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An adult patient with mucolipidosis III alpha/beta presenting with parkinsonism2013

Author(s)

Journal Title

Data Source

[Journal Article] An adult patient with mucolipidosis III alpha/beta presenting with parkinsonism2013

Author(s)

Journal Title

Hara Munetsugu 原宗嗣

原宗嗣ハラムネツグ

HARA Munetsugu 原宗嗣

[Presentation] 繰り返す熱性けいれんからミオクロニー欠伸てんかんへ移行した1q44微小欠失症候群の一例．2023