Miyashita Tomoharu 宮下知治

… Alternative Names

Tomoharu Miyashita 宮下知治

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Researcher Number	30397210
Other IDs
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Affiliation (Current)	2025: 金沢大学, 医学系, 協力研究員
Affiliation (based on the past Project Information) *help	2024: 金沢大学, 医学系, 協力研究員 2022 – 2023: 金沢大学, がん進展制御研究所, 研究協力員 2020 – 2021: 金沢医科大学, 医学部, 准教授 2019 – 2020: 金沢大学, 医学系, 協力研究員 2019: 金沢大学, 附属病院, 講師 … More 2016 – 2018: 金沢大学, 附属病院, 助教 2015: 金沢大学, 医学系, 助教 2014: 金沢大学, 医学系, 特任助教 2014: 金沢大学, 大学病院, 特任助教 2013: 金沢大学, 大学病院, 医員 Less
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related / Biomedical engineering/Biomaterial science and engineering / General surgery
Keywords	Principal Investigator がん微小環境 / 逆流性食道炎 / 食道発癌 / GSK 3β / 化学予防 / がん幹細胞 / 細胞老化 / 治療抵抗性 / がん関連線維芽細胞 / 膵癌 … More / STAT3 / がん悪性形質 / GSK3β / 癌 / メトホルミン / エピジェネティック / Valpronic acid / 腫瘍微小環境 … More Except Principal Investigator 大腸がん / 糖代謝改変 / 癌 / 上皮間葉転換 / 血小板 / 膵癌 / がん幹細胞形質 / がん幹細胞性 / 腫瘍浸潤 / 治療獲得耐性 / 膵がん / 分子標的薬 / タイトジャンクション / 食道自然発癌モデル / 食道発癌 / Claudin18.2 / 細胞核分裂 / 微小環境 / 間質 / Podoplanin / 血管外血小板 / SASP / 細胞老化 / 核膜孔複合体 / 核移送 / β-カテニン / 生体制御・治療 / 酸化ストレス応答因子 / 細胞周期阻害因子 / 幹細胞制御因子 / がん幹細胞 / 浸潤・転移 / 細胞死 / G タンパク質共役受容体 / Gタンパク質共役受容体 / 転移 / 浸潤 / 遊走 / 悪性腫瘍 / リノール酸 / 酸化遊離脂肪酸 / G2A / 治療 / 病態 / 好中球 / 肝類同閉塞症候群 / 抗癌剤 / 肝類洞変則症候群 / 化学療法 / モノクロタリン / シロスタゾール / veno-occlusive disease / 肝類洞閉塞症候群 / 上皮-間葉転換 / 化学療法抵抗性 / 乳癌 / 自然免疫 / MICA / 自然免疫機構 / Valpronic acid / Gemcitabine / MICA/B / 免疫逃避機構 / 術前化学療法 Less

Elucidation of the Esophageal Carcinogenesis Mechanism Centered on Claudin18.2 and Development of Novel Therapeutic Strategies
- Principal Investigator
  
  稲木紀幸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanazawa University
治療抵抗性膵癌のがん幹細胞性とがん関連性線維芽細胞老化を統御する分子経路の解明Principal Investigator
- Principal Investigator
  
  宮下知治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanazawa University
Exploration of the molecular pathways interconnecting malignant phenotypes in therapy-resistant pancreatic cancer toward development of new strategy against therapy resistance
- Principal Investigator
  
  源利成
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanazawa University
Inhibitor of GSK3beta impedes the development of reflux-induced esophageal cancerPrincipal Investigator
- Principal Investigator
  
  Miyashita Tomoharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanazawa University
  Kanazawa Medical University
Investigation of molecular pathways linking aberrant glucose metabolism and mitotic process in colorectal cancer and its application to development of cancer therapy
- Principal Investigator
  
  Minamoto Toshinari
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanazawa University
THE INFLUENCE OF SENESCENT STROMA ON PDAC
- Principal Investigator
  
  Ohta Tetsuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Alarm signal by dead cells activated progressive properties of tumor cells.
- Principal Investigator
  
  KISHIMOTO Koji
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  The University of Tokushima
Antitumor Effects of Metformin Due to Regulation of the Immunosuppressive Tumor MicroenvironmentPrincipal Investigator
- Principal Investigator
  
  Miyashita Tomoharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Elucidation of pathophysiology of Sinusoidal Obstruction Syndrome and development of new prevention and treatment methods
- Principal Investigator
  
  Tajima Hidehiro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Investigation of biological basis of GSK3beta-targeted therapy and its translation to colorectal cancer treatment
- Principal Investigator
  
  MINAMOTO Toshinari
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Identification and functional analysis of nuclear pore complex components that function to transport beta-catenin between cytoplasm and nucleus
- Principal Investigator
  
  Minamoto Toshinari
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Elucidation of metastatic mechanism of breast cancer cells by the extravascular platelet aggregation and new therapeutic development
- Principal Investigator
  
  INOKUCHI MASAFUMI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kanazawa University
Impact of inflammation-metaplasia-adenocarcinoma sequence and inflammatory microenvironment in esophageal carcinogenesis using surgical rat modelsPrincipal Investigator
- Principal Investigator
  
  Tomoharu Miyashita
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Low-dose gemcitabine induces major histocompatibility complex class I-related chain A/B expression and enhances an antitumor innate immune response in pancreatic cancer.
- Principal Investigator
  
  Ohta Tetsuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Glycogen synthase kinase 3β: the nexus of chemoresistance, invasive capacity, and cancer stemness in pancreatic cancer2024
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Osamu Takeuchi, Takeo Shimasaki, Tomoharu Miyashita, Toshinari Minamoto
- Journal Title
  
  Cancer Drug Resist .
  
  Volume: 7 Pages: 4-4
- DOI
  10.20517/cdr.2023.84
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07227, KAKENHI-PROJECT-23K24403
[Journal Article] GSK3β を基軸とする食道発がん機構の解明と新規治療戦略の開発2022
- Author(s)
  宮下知治、源利成、高村博之
- Journal Title
  
  Medical Science Digest
  
  Volume: 48 Pages: 61-63
- Data Source
  KAKENHI-PROJECT-20K09100
[Journal Article] Glycogen synthase kinase-3β participates in acquired resistance to gemcitabine in pancreatic cancer2020
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Dilireba Bolidong, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 12 Pages: 4405-4416
- DOI
  10.1111/cas.14668
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07710, KAKENHI-PROJECT-19H03727
[Journal Article] Potential therapeutic effect of targeting glycogen synthase kinase 3β in esophageal squamous cell carcinoma2020
- Author(s)
  Dilireba Bolidong, Takahiro Domoto, Masahiro Uehara, Hemragul Sabit, Tomoyuki Okumura, Yoshio Endo, Mitsutoshi Nakada, Itasu Ninomiya, Tomoharu Miyashita, Richard W Wong, Toshinari Minamoto
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 11807-11807
- DOI
  10.1038/s41598-020-68713-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07710, KAKENHI-PROJECT-19H03727
[Journal Article] Preventive effect of oral hangeshashinto (TJ-14) on the development of reflux-induced esophageal cancer2018
- Author(s)
  Miyashita T, Kono T, Matsui D, Yamazaki Y, Sadatomi D, Fujitsuka N, Nakanuma S, Okamoto K, Makino I, Kinoshita J, Nakamura K, Oyama K, Tajima H, Takamura H, Ninomiya I, Fushida S, Mukaisho K, Harmon JW, Ohta T
- Journal Title
  
  Surgery
  
  Volume: 164 Issue: 1 Pages: 49-55
- DOI
  10.1016/j.surg.2018.02.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10493
[Journal Article] 膵がんの増殖，浸潤と治療不応性を繋ぐ治療標的GSK3β．2017
- Author(s)
  島崎猛夫，堂本貴寛，宮下知治，中田光俊，元雄良治，太田哲生，源利成．
- Journal Title
  
  肝胆膵
  
  Volume: 75 Pages: 769-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04928
[Journal Article] Biological basis and clinical trial of glycogen synthase kinase-3β-targeted therapy by drug repositioning for glioblastoma2016
- Author(s)
  Furuta T, Sabit H, Yu D, Miyashita K, Kinoshita M, Uchiyama N, Hayashi Y, Hayashi Y, Minamoto T, Nakada M
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 14 Pages: 22811-22824
- DOI
  10.18632/oncotarget.15206
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293322, KAKENHI-PROJECT-15K19957, KAKENHI-PROJECT-16K10751, KAKENHI-PROJECT-15K10295, KAKENHI-PROJECT-16K15645, KAKENHI-PROJECT-15H04928
[Journal Article] Ischemia reperfusion-facilitated sinusoidal endothelial cell injury in liver transplantation and the resulting impact of extravasated platelet aggregation2016
- Author(s)
  Tomoharu Miyashita
- Journal Title
  
  European Surgery
  
  Volume: 48 Issue: 2 Pages: 92-98
- DOI
  10.1007/s10353-015-0363-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10158
[Journal Article] Platelets surrounding primary tumor cells are related to chemoresistance.2016
- Author(s)
  Ishikawa S, Miyashita T, Inokuchi M, Itas u Ninomiya, A. Karim Ahmed, John W. Harman, Sachio Fushida and Tetsuo Ohta
- Journal Title
  
  Oncol Rep.
  
  Volume: 36(2) Issue: 2 Pages: 787-794
- DOI
  10.3892/or.2016.4898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461943
[Journal Article] Low-dose gemcitabine induces major histicompatibility complex class Ⅰ-related chain A/B expression and enhances an antitumorinnate immune response in pancreatic cancer.2015
- Author(s)
  Miyashita T, et al.
- Journal Title
  
  Clin Exp Med
  
  Volume: EPub Issue: 1 Pages: 1-13
- DOI
  10.1007/s10238-015-0394-x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04928, KAKENHI-PROJECT-25462106, KAKENHI-PROJECT-25462107
[Journal Article] Metastasis-promoting role of extravasated platelet activation in tumor.2015
- Author(s)
  Miyashita T, et al.
- Journal Title
  
  J Surg Res
  
  Volume: 193 Issue: 1 Pages: 289-293
- DOI
  10.1016/j.jss.2014.07.037
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04928
[Journal Article] Ischemia reperfusion-facilitated sinusoidal endothelial cell injury in liver transplantation and the resulting impact of extravasated platelet aggregation2015
- Author(s)
  Miyashita T, et al.
- Journal Title
  
  Eur Surg
  
  Volume: Epub
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04928
[Journal Article] Impact of histone deacetylase 1 and metastasis-associated gene 1 expression in esophageal carcinogenesis2014
- Author(s)
  7.Miyashita T, Tajima H, Munemoto M, Shah F, Harmon J.W, Watanabe T, Shoji M, Okamoto K, Nakanuma S, Sakai S, Kinoshita J, Makino I, Nakamura K< Hayashi H, Oyama K, Inokuchi M, Nakagawara H, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Mukaisho K, Fujimur T.
- Journal Title
  
  Oncology Letters
  
  Volume: 8 Issue: 2 Pages: 758-764
- DOI
  10.3892/ol.2014.2176
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462016
[Journal Article] Impact of inflammation-metaplasia-adenocarcinoma sequence and inflammatory microenvironment in esophageal carcinogenesis using surgical rat models.2014
- Author(s)
  Miyashita T, Tajima H, Shah FA, Oshima M, Makino I, Nakagawara H, Kitagawa H, Fujimura T, Harmon JW, Ohta T.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 21 Issue: 6 Pages: 2012-2019
- DOI
  10.1245/s10434-014-3537-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462016
[Journal Article] Impact of Inflammation-Metaplasia-Adenocarcinoma Sequence and Inflammatory Microenvironment in Esophageal Carcinogenesis Using Surgical Rat Models2014
- Author(s)
  Miyashita T, Tajima H, Shah FA, Oshima M, Makino I, Nakagawara H, Kitagawa H, Fujimura T, Harmon JW, Ohta T.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462016
[Journal Article] 膵癌における免疫化学療法の可能性2013
- Author(s)
  宮下知治、田島秀浩、正司政寿、中沼伸一、酒井清祥、林　泰寛、中川原寿俊、高村博之、北川裕久、太田哲生
- Journal Title
  
  癌と化学療法
  
  Volume: 40 Pages: 1600-1602
- Data Source
  KAKENHI-PROJECT-25462106
[Presentation] 新規GSK3β阻害剤による膵がんゲムシタビン獲得耐性の克服2023
- Author(s)
  堂本貴寛，上原将大，竹中哲，宮下知治，源利成
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] GSK3β阻害剤のゲムシタビン耐性獲得膵がんの前臨床的評価2023
- Author(s)
  堂本貴寛，上原将大，Ludimila Cavalcante，Frank Giles，宮下知治，源利成
- Organizer
  第34回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] Inhibitor of GSK3β impedes the development of reflux-induced esophageal cancer2023
- Author(s)
  Tomoharu Miyashita, Hiroyuki Takamura, Toshinari Miyamoto, John W Harmon
- Organizer
  Society of Surgical Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09100
[Presentation] 食道発癌過程におけるSTAT3/GSK3βの関与とGSK3β阻害による微小環境の変化2023
- Author(s)
  宮下知治，源利成，島崎猛夫，佐々木省三，稲木紀幸，藤村隆
- Organizer
  第34回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] ゲムシタビン耐性膵がんにおけるcyclin D2の過剰発現と治療標的としての可能性2023
- Author(s)
  上原将大，竹中哲，堂本貴寛，堀家慎一，高橋智聡，宮下知治，源利成
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] 膵がんにおけるゲムシタビン耐性克服のためのcyclin D2関連経路の標的化2023
- Author(s)
  上原将大，竹中哲，堂本貴寛，堀家慎一，高橋智聡，宮下知治，源利成
- Organizer
  第34回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] GSK3βは膵がんの獲得耐性と浸潤能，がん幹細胞性を統合する2022
- Author(s)
  堂本貴寛，上原将大，宮下知治，源利成
- Organizer
  第33回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] GSK3β は薬剤耐性獲得膵がんの悪性進展に寄与する2022
- Author(s)
  堂本貴寛，竹中哲，上原将大，古川龍彦，宮下知治，源利成
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] Glycogen synthase kinase-3β participates in acquired resistance to gemcitabine in pancreatic cancer2022
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Dilireba Bolidong, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  The 7th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] バレット食道から発癌過程での微小環境の変化とGSK3β阻害による抑制効果2022
- Author(s)
  橋本明史，宮下知治，島崎猛夫，源利成，高村博之
- Organizer
  第33回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] GSK3βは膵がんのゲムシタビン獲得耐性に寄与する2022
- Author(s)
  上原将大，堂本貴寛，ディリラバボリドン，宮下知治，源利成
- Organizer
  第31回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] GSK3β interconnects tumor invasion and stemness in pancreatic cancer acquiring resistance to gemcitabine2022
- Author(s)
  Takahiro Domoto, Masahiro Uehara, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  The 7th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24403
[Presentation] GSK3βはSTAT3の活性化を介して膵がんのゲムシタビン耐性獲得に寄与する2021
- Author(s)
  堂本貴寛，竹中哲，上原将大，ボリドンディレレバ，古川龍彦，宮下知治，源利成
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] Potential therapeutic effect of targeting glycogen syntase kinase (GSK)3β in esophageal squamous cell carcinoma (ESCC)2021
- Author(s)
  Dilireba Bolidong, Takahiro Domoto, Masahiro Uehara, Hemragul Sabit, Tomoyuki Okumura, Yoshio Endo, Mitutoshi Nakada, Tomoharu Miyashita, Richard W. Wong, Toshinari Minamoto
- Organizer
  The 10th International Conference of the International Society of Gastroenterological Carcinogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] Glycogen synthase kinase (GSK) 3β participates in acquired resistance to gemcitabine in pancreatic cancer2021
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Dilireba Bolidong, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  The 10th International Conference of the International Society of Gastroenterological Carcinogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] GSK3β interconnects the malignant properties in therapy-resistant pancreatic cancer2021
- Author(s)
  Takahiro Domoto, Masahiro Uehara, Satoshi Takenaka, Dilireba Bolidong, Tatsuhiko Furusawa, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto
- Organizer
  The 10th International Conference of the International Society of Gastroenterological Carcinogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] Glycogen synthase kinase（GSK）3βは膵がんのゲムシタビン獲得耐性に寄与する2021
- Author(s)
  上原将大，堂本貴寛，竹中哲，ディリレバ　ボリドン，竹内修，宮下知治，源利成
- Organizer
  第32回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] GSK3βは膵がんの難治性腫瘍形質を連関する2021
- Author(s)
  堂本貴寛，上原将大，竹中哲，ディリレバ　ボリドン，古川龍彦，竹内修，宮下知治、源利成
- Organizer
  第32回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] GSK3β阻害による食道扁平上皮がんの治療効果とメカニズム2021
- Author(s)
  ディリレバ　ボリドン，堂本貴寛，上原将大，アムラ　サビット，奥村知之，遠藤良夫，中田光俊，宮下知治，リチャード　ウォング，源利成
- Organizer
  第32回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] GSK3β阻害による食道扁平上皮がんの治療効果とメカニズム2020
- Author(s)
  ボリドンディリレバ，堂本貴寛，上原将大，奥村知之，遠藤良夫，中田光俊，二宮致，宮下知治，ウォンリチャード，源利成
- Organizer
  第31回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] GSK3βはゲムシタビン耐性獲得膵がん細胞の幹細胞性と浸潤能に関与する2020
- Author(s)
  堂本貴寛，宮下知治，竹中哲，上原将大，ボリドンディリレバ，太田哲生，源利成
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] Glycogen synthase kinase (GSK)-3βを標的とする膵がんのゲムシタビン獲得耐性の克服2020
- Author(s)
  上原将大，堂本貴寛，竹中哲，ディリラバボリドン，島崎猛夫，宮下知治，太田哲生，源利成
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] 膵がん細胞のゲムシタビン耐性化に伴う悪性進展機構の解明とGSK3βの役割2020
- Author(s)
  堂本貴寛，宮下知治，Bolidong Dilireba，上原将大，竹中哲, 竹内修，太田哲生, 源利成
- Organizer
  29回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] GSK3βは膵がんのゲムシタビン耐性獲得に寄与する2020
- Author(s)
  上原将大，堂本貴寛，竹中哲，ディリラバボリドン，竹内修，宮下知治，源利成
- Organizer
  第31回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] 食道扁平上皮がんのGSK3β阻害は細胞周期停止とアポトーシスを誘導する．2019
- Author(s)
  ディリラバボリドン，堂本貴寛，上原将大，奥村智之，遠藤良夫，イリアピコ，宮下知治，中田光俊，源利成．
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] PANCREATIC SENESCENT STROMA INFLUENCE ON PROGNOSIS IN PDAC2019
- Author(s)
  Yuto Kitano, Tomoharu Miyashita, Tetsuo Ohta
- Organizer
  DDW2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10693
[Presentation] GSK3βは膵がんの幹細胞性，浸潤能，薬剤耐性獲得にそれぞれ連関する．2019
- Author(s)
  堂本貴寛，宮下知治，竹中哲，上原将大，太田哲夫，源利成．
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] 膵がんのゲムシタビン獲得耐性はglycogen synthase kinase (GSK)-3βに依存する．2019
- Author(s)
  上原将大，堂本貴寛，竹中哲，ディリラバ　ボリドン，ピコイリア，島崎猛夫，宮下知治，太田哲生，源利成．
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] 膵がん細胞の薬剤耐性化に伴うがん悪性形質とGSK3βの病理作用．2019
- Author(s)
  堂本貴寛, 竹中哲, 宮下知治, 上原将大, 竹内修, 太田哲生, 源利成.
- Organizer
  第28回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] 膵がん細胞のゲムシタビン耐性化においてGSK3βは幹細胞性と浸潤能を増強する．2019
- Author(s)
  堂本貴寛, 竹中哲, 宮下知治, 上原将大, 太田哲生, 源利成．
- Organizer
  第28回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19H03727
[Presentation] 酸化脂質膜受容体であるヒトG2Aは脳腫瘍細胞の上皮間葉転換様プロセスを制御する2018
- Author(s)
  岸本幸治、原口崇、清水健志、井出宗典、宮下知治、大野綾子、二川健、和泉孝志
- Organizer
  第59回日本生化学会中国四国支部例会
- Data Source
  KAKENHI-PROJECT-16K01360
[Presentation] 酸化脂質膜受容体であるヒトG2Aは脳腫瘍細胞の上皮間葉転換様プロセスを制御する2018
- Author(s)
  岸本幸治、原口崇、清水健志、井出宗則、宮下知治、大野綾子、二川健、和泉孝志
- Organizer
  第59回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-16K01360
[Presentation] バレット食道から発癌過程での微小環境の変化とGSK3β 阻害による抑制2018
- Author(s)
  宮下知治，源　利成，太田哲生
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K10493
[Presentation] ゲムシタビン獲得耐性膵がん細胞の幹細胞性と浸潤能におけるGSK3βの作用．2017
- Author(s)
  堂本貴寛，竹中哲，宮下知治，上原将大，太田哲生，源利成．
- Organizer
  第26回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] GSK3βはゲムシタビン獲得耐性膵がんの浸潤を促進する．2017
- Author(s)
  堂本貴寛，宮下知治，竹中哲，上原将大，太田哲生，源利成．
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] 膵がん治療耐性に伴う幹細胞性とGSK3β/STAT3経路の機能解析．2017
- Author(s)
  竹中哲，宮下知治，上原将大，堂本貴寛，源　利成，太田哲生．
- Organizer
  第26回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] 膜受容体G2Aはアストロサイトーマ細胞株にグリア間葉移行を誘導する2017
- Author(s)
  原口崇、清水健志、宮下知治、和泉孝志
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K01360
[Presentation] Glycogen synthase kinase (GSK)3βの食道扁平上皮がん促進作用の検討．2017
- Author(s)
  ボリドンディリレバ，堂本貴寛，奥村知之，遠藤良夫，上原将大，ピコイリア，宮下知治，源利成．
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] 膵がんのゲムシタビン耐性獲得におけるglycogen synthase kinase (GSK)-3βの役割り．2017
- Author(s)
  上原将大，堂本貴寛，竹中哲，ピコイリア，島崎猛夫，宮下知治，太田哲生，源利成．
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] Putative role of glycogen synthase kinase (GSK)-3β in acquired resistance to gemcitabine (GEM) in pancreatic cancer.2017
- Author(s)
  Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Ilya Pyko, Takeo Shimasaki, Tomoharu Miyashita, Tetsuo Ohta, Toshinari Minamoto.
- Organizer
  The 9th International Conference on the International Society of Gastroenterological Carcinogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] TJ-14による食道発癌抑制とその機序．2016
- Author(s)
  宮下知治，ほか，源利成
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜，横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] TJ-14による食道発癌抑制とその機序．2016
- Author(s)
  宮下知治，源利成，ほか
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜，横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K15493
[Presentation] Low dose gemcitabine induces major histocompatibility complex class l-related chain A/B expression and activates γδT　cell function in pancreatic cancer2015
- Author(s)
  Miyashita T, et al.
- Organizer
  The 61st Annual Congress of International College of Surgeons Japan Section
- Place of Presentation
  京王プラザホテル，新宿，東京
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] Gemcitabine induces major histocompatibility complex class I-related chain A/B expression, activating γδ T cell function in pancreatic cancer2015
- Author(s)
  Miyashita T, et al.
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  Walter E. Washington Convention Center, Washington DC, USA
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] The metastasis-promoting roles of extravasated platelet aggregation in pancreatic cancer and stroma2015
- Author(s)
  Miyashita T, et al.
- Organizer
  3rd International Conference of Federation of Asian Clinical Oncology (FACO)
- Place of Presentation
  京都国際会議場，京都
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-15H04928
[Presentation] Gemcitabine induces Major Histocompatibility Complex Class I-related chain A/B expression, activating γδ T cell function in pancreatic cancer2015
- Author(s)
  Miyashita　T,　 Miki　K, Harmon JW, Ali K. Ahmed ,Tajima H, Fushida S, Ohta T
- Organizer
  Digestive Disease　Week　2015
- Place of Presentation
  Washington（USA）
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462106
[Presentation] 乳癌原発巣における血小板の役割：EMT誘導と化学療法抵抗性2015
- Author(s)
  石川聡子、井口雅史、宮下知治、林　泰寛、尾山勝信、中川原寿俊、田島秀浩、高村博之、二宮　致、伏田幸夫、太田哲生
- Organizer
  第３７回日本癌局所療法研究会
- Place of Presentation
  幕張メッセ国際会議場(千葉県千葉市)
- Year and Date
  2015-07-10
- Data Source
  KAKENHI-PROJECT-26461943
[Presentation] Low dose gemcitabine induces Major Histocompatibility complex class l-related chain A/B expression and activates γδT　cell function in pancreatic cancer2015
- Author(s)
  Miyashita T, Miki K, Maekawa R, Makino I, Oyama K, Tajima H, Takamura H, Fushida S, Ahmed AK, Duncan MD, Harmon JW, Ohta T.
- Organizer
  The 61st Annual Congress of International College of Surgeons Japan Section
- Place of Presentation
  Tokyo
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462106
[Presentation] 膵癌化学療法による自然免疫誘導の可能性2013
- Author(s)
  宮下知治，岡本浩一，酒井清祥，牧野　勇，中村慶史，林泰寛，尾山勝信，中川原寿俊，田島秀浩，高村博之，二宮　致，北川裕久，伏田幸夫，藤村　隆，太田哲生
- Organizer
  第38回日本外科系連合学会学術集会
- Place of Presentation
  東京、ハイアットリージェンシー東京
- Data Source
  KAKENHI-PROJECT-25462106
[Presentation] 逆流発癌モデルを用いた発癌過程での微小環境の解明2013
- Author(s)
  宮下知治，田島秀浩，中沼伸一，牧野　勇，林　泰寛，梅田尚季，中川原寿敏，高村博之，北川裕久，藤村　隆，太田哲生
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡国際会議場(福岡市）
- Data Source
  KAKENHI-PROJECT-25462016
[Presentation] 膵癌における免疫細胞療法の新機軸を求めて-その基礎と臨床-2013
- Author(s)
  宮下知治，中沼伸一､酒井清祥，牧野　勇，林　泰寛，中川原寿俊，田島秀浩，高村博之，北川裕久，藤村　隆，三木健次，竹村公延，前川隆司，梅田尚季，太田哲生
- Organizer
  第44回日本膵臓学会大会
- Place of Presentation
  仙台、仙台国際センター
- Data Source
  KAKENHI-PROJECT-25462106
[Presentation] The inflammatory microenvironment in Duodeno-Esophageal reflux induced esophageal carcinogenesis in a sequential rat model2013
- Author(s)
  Miyashita T, Munemoto M, Furawn Ashah, John W. Harmon, Fujimura T, Matsui D, Oshima M, Ohta T.
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando (USA)
- Data Source
  KAKENHI-PROJECT-25462016
[Presentation] Platelet predominant breast cancer is a new predictor for pathological complete response to neoadjuvant chemotherapy
- Author(s)
  Satoko Ishikawa, Masafumi Inokuchi, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
- Organizer
  Sanantonio breast cancer symposium 2014
- Place of Presentation
  Henry B. Gonzalez Convention Center (San Antonio, Texas, USA)
- Year and Date
  2014-12-09 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-26461943
[Presentation] 血小板がEMT を誘導し乳癌原発巣の化学療法抵抗性と関連する
- Author(s)
  石川聡子、井口雅史、宮下知治、田島秀浩、高村博之、二宮　致、伏田幸夫、藤村　隆、太田哲生
- Organizer
  第22回日本乳癌学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-07-10 – 2014-07-12
- Data Source
  KAKENHI-PROJECT-26461943
[Presentation] Tumor cells surrounded by platelets showed EMT and chemoresistance in primary breast cancer.
- Author(s)
  石川聡子、井口雅史、宮下知治、田島秀浩、高村博之、二宮　致、伏田幸夫、藤村　隆、太田哲生
- Organizer
  第23回日本がん転移学会学術集会
- Place of Presentation
  金沢市文化ホール（石川県金沢市）
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26461943

1. Ohta Tetsuo (40194170)

# of Collaborated Projects: 8 results

# of Collaborated Products: 18 results
2. MINAMOTO Toshinari (50239323)

# of Collaborated Projects: 7 results

# of Collaborated Products: 39 results
3. WONG Richard (30464035)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Tajima Hidehiro (00436825)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. DOMOTO Takahiro (80635540)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
6. 島崎猛夫 (50377420)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. INOKUCHI MASAFUMI (90401918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. SOGA Tomoyoshi (60338217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SEIO Kohshi (20313356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KISHIMOTO Koji (50280699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. ISHIGAKI Yasuhito (20232275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 亀村典生 (10632656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 稲木紀幸 (40436837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 高村博之 (40377396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. FURUTA Takuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. SABIT Hemragul

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 中田光俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyashita Tomoharu 宮下 知治

Tomoharu Miyashita 宮下 知治

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治療抵抗性膵癌のがん幹細胞性とがん関連性線維芽細胞老化を統御する分子経路の解明Principal Investigator

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Inhibitor of GSK3beta impedes the development of reflux-induced esophageal cancerPrincipal Investigator

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Antitumor Effects of Metformin Due to Regulation of the Immunosuppressive Tumor MicroenvironmentPrincipal Investigator

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Impact of inflammation-metaplasia-adenocarcinoma sequence and inflammatory microenvironment in esophageal carcinogenesis using surgical rat modelsPrincipal Investigator

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[Journal Article] Glycogen synthase kinase 3β: the nexus of chemoresistance, invasive capacity, and cancer stemness in pancreatic cancer2024

Miyashita Tomoharu 宮下知治

Tomoharu Miyashita 宮下知治