Mishima Yoshiyuki 三島義之

Researcher Number	30397864
Other IDs
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 助教
Affiliation (based on the past Project Information) *help	2018 – 2025: 島根大学, 学術研究院医学・看護学系, 助教 2017: 島根大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator 炎症性腸疾患 / 腸内細菌 / 古細菌 / 腸内細菌叢 / 腸管免疫 / 腸内微生物 / アーキア / mucosal immnology / gut microbiota / irritable bowel syndrome … More / colitis / archaea / 自然免疫 / 免疫学 / 8 / 7 / 6 / 5 / Toll like recepter / IL-10 / 制御性B細胞 / Toll like receptor / 粘膜免疫 / 制御性免疫細胞 … More Except Principal Investigator アデノシン三リン酸 / IL-10 / クローン病 / 制御性B細胞 / Ahr / Clec4a4 / 制御性好酸球 / 好酸球性胃腸炎 / Toll-like receptor 9 / Citrobacter rodentium / 感染後過敏性腸症候群 / 制御性T細胞 / 腸管粘膜透過性 / microbiome / diagnosis / tight junction / intestinal permeability / 炎症性腸疾患 / 粘膜透過性 / IBDの予後予測 / 腸粘膜透過性 / 腸粘膜バリア / アデノシン三リン酸（ATP） / P2X7受容体 / 腸管免疫 / Crohn病 / 自然免疫 / 潰瘍性大腸炎 / ATP Less

潰瘍性大腸炎の難治化形成における消化管粘膜好酸球の解析と治療応用Principal Investigator
- Principal Investigator
  
  三島義之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Shimane University
A study regarding a novel anti-inflammatory eosinophil subset on pathogenesis of eosiophilic gastroenteritis
- Principal Investigator
  
  石原俊治
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Shimane University
感染後過敏性腸症候群におけるToll様受容体9-ブラジキニン経路の解明と治療応用
- Principal Investigator
  
  古谷聡史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Shimane University
Analysis of B cell functions regulating intestinal mucosal permeability on the pathogenesis of Crohn's disease
- Principal Investigator
  
  Ishihara Shunji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Shimane University
A study for intestinal archaea in human health and diseasePrincipal Investigator
- Principal Investigator
  
  MISHIMA YOSHIYUKI
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Shimane University
A challenge study to establish early diagnosis method for inflammatory bowel diseases by utilizing revolutionary quantifying method for intestinal barrier function
- Principal Investigator
  
  Usuda Haruki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Shimane University
Elucidation of a novel mechanism leading regulatory B cells dysfunction of in Crohn's disease
- Principal Investigator
  
  Ishihara Shunji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Shimane University
A study of microbiota activated regulatory B cells in inflammatory bowel diseases.Principal Investigator
- Principal Investigator
  
  Mishima Yoshiyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shimane University

All 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Low Fecal Calprotectin Predicts Histological Healing in Patients with Ulcerative Colitis with Endoscopic Remission and Leads to Prolonged Clinical Remission2022
- Author(s)
  Kawashima Kousaku、Oshima Naoki、Kishimoto Kenichi、Kataoka Masatoshi、Fukunaga Mai、Kotani Satoshi、Sonoyama Hiroki、Oka Akihiko、Mishima Yoshiyuki、Kazumori Hideaki、Ishikawa Noriyoshi、Araki Asuka、Ishihara Shunji
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: 29 Issue: 3 Pages: 359-366
- DOI
  10.1093/ibd/izac095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07961, KAKENHI-PROJECT-22K08542, KAKENHI-PROJECT-19K08907
[Journal Article] Long-lasting renal dysfunction following tacrolimus induction therapy in ulcerative colitis patients2022
- Author(s)
  Cha Na、Oshima Naoki、Kishimoto Kenichi、Kotani Satoshi、Okimoto Eiko、Yazaki Tomotaka、Sonoyama Hiroki、Oka Akihiko、Mishima Yoshiyuki、Shibagaki Kotaro、Tobita Hiroshi、Kawashima Kousaku、Ishimura Norihisa、Ishihara Shunji
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 70 Issue: 3 Pages: 297-303
- DOI
  10.3164/jcbn.21-139
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07961, KAKENHI-PROJECT-22K08542, KAKENHI-PROJECT-19K08907
[Journal Article] Intermittent Purpura Development Associated with Leukocytoclastic Vasculitis Induced by Infliximab for Crohn's Disease2021
- Author(s)
  Kishimoto Kenichi、Kawashima Kousaku、Fukunaga Mai、Kotani Satoshi、Sonoyama Hiroki、Oka Akihiko、Mishima Yoshiyuki、Oshima Naoki、Ishimura Norihisa、Ishikawa Noriyoshi、Maruyama Riruke、Ishihara Shunji
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 3 Pages: 385-389
- DOI
  10.2169/internalmedicine.5340-20
- NAID
  130007979732
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-02-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09383, KAKENHI-PROJECT-18K07971, KAKENHI-PROJECT-19K08907
[Journal Article] Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice2021
- Author(s)
  Matsumoto Kenjiro、Takata Kana、Yamada Daisuke、Usuda Haruki、Wada Koichiro、Tada Maaya、Mishima Yoshiyuki、Ishihara Shunji、Horie Syunji、Saitoh Akiyoshi、Kato Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 16276-16276
- DOI
  10.1038/s41598-021-95916-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07109, KAKENHI-PROJECT-19H04032, KAKENHI-PROJECT-21K07961
[Journal Article] Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome2021
- Author(s)
  Mishima Yoshiyuki、Ishihara Shunji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 19 Pages: 10235-10235
- DOI
  10.3390/ijms221910235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07961
[Journal Article] Differential gene expression analysis of dasatinib-induced colitis in a patient with chronic myeloid leukemia followed for 3?years: a case report2021
- Author(s)
  Oshima Naoki、Mishima Yoshiyuki、Shibagaki Kotaro、Kawashima Kousaku、Ishimura Norihisa、Ikejiri Fumiyoshi、Onishi Chie、Okada Takahiro、Inoue Masaya、Moriyama Ichiro、Suzumiya Junji、Kinoshita Yoshikazu、Ishihara Shunji
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 21 Issue: 1 Pages: 19-19
- DOI
  10.1186/s12876-020-01584-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09383, KAKENHI-PROJECT-18K07971, KAKENHI-PROJECT-19K08907
[Journal Article] Detection and Quantification of Transforming Growth Factor-β1 Produced by Murine B Cells: Pros and Cons of Different Techniques2021
- Author(s)
  Mishima Yoshiyuki、Oka Akihiko、Ishihara Shunji
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2270 Pages: 113-124
- DOI
  10.1007/978-1-0716-1237-8_7
- ISBN
  9781071612361, 9781071612378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07971
[Journal Article] Ten-year follow-up study of linear immunoglobulin A dermatosis complicated with ulcerative colitis2020
- Author(s)
  Sonoyama H, Mishima Y, Ishihara S, Oshima N, Moriyama I, Kawashima K, Chinuki Y, Morita E, Kinoshita Y
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: 13 Issue: 2 Pages: 164-169
- DOI
  10.1007/s12328-019-01047-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09383, KAKENHI-PROJECT-18K07971
[Journal Article] Molecular Mechanisms of Microbiota-Mediated Pathology in Irritable Bowel Syndrome2020
- Author(s)
  Mishima Yoshiyuki、Ishihara Shunji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 22 Pages: 8664-8664
- DOI
  10.3390/ijms21228664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07971
[Journal Article] Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10?producing regulatory B cells2019
- Author(s)
  Mishima Yoshiyuki、Oka Akihiko、Liu Bo、Herzog Jeremy W.、Eun Chang Soo、Fan Ting-Jia、Bulik-Sullivan Emily、Carroll Ian M.、Hansen Jonathan J.、Chen Liang、Wilson Justin E.、Fisher Nancy C.、Ting Jenny P.Y.、Nochi Tomonori、Wahl Angela、Garcia J. Victor、Karp Christopher L.、Sartor R. Balfour
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 129 Issue: 9 Pages: 3702-3716
- DOI
  10.1172/jci93820
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09382, KAKENHI-PROJECT-17K19882, KAKENHI-PROJECT-18H03969
[Journal Article] Interleukin-33 delays recovery of mucosal inflammation via downregulation of homeostatic ABCG5/8 in the colon2019
- Author(s)
  Mishima Yoshiyuki、Sonoyama Hiroki、Ishihara Shunji、Oshima Naoki、Moriyama Ichiro、Kawashima Kousaku、Kinoshita Yoshikazu
- Journal Title
  
  Laboratory Investigation
  
  Volume: 100 Issue: 3 Pages: 491-502
- DOI
  10.1038/s41374-019-0329-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09383, KAKENHI-PROJECT-18K07971
[Journal Article] Capabilities of fecal calprotectin and blood biomarkers as surrogate endoscopic markers according to ulcerative colitis disease type2019
- Author(s)
  Sonoyama Hiroki、Kawashima Kousaku、Ishihara Shunji、Kotani Satoshi、Fukuba Nobuhiko、Oka Akihiko、Kusunoki Ryusaku、Tada Yasumasa、Mishima Yoshiyuki、Oshima Naoki、Moriyama Ichiro、Yuki Takafumi、Onishi Koji、Kinoshita Yoshikazu
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 64 Issue: 3 Pages: 265-270
- DOI
  10.3164/jcbn.18-92
- NAID
  130007641427
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09383, KAKENHI-PROJECT-18K07971
[Journal Article] Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation2019
- Author(s)
  Oka Akihiko、Mishima Yoshiyuki、Liu Bo、Herzog Jeremy W.、Steinbach Erin C.、Kobayashi Taku、Plevy Scott E.、Sartor R. Balfour
- Journal Title
  
  Cells
  
  Volume: 8 Issue: 10 Pages: 1121-1121
- DOI
  10.3390/cells8101121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09382, KAKENHI-PROJECT-17K09393
[Journal Article] Capabilities of fecal calprotectin and blood biomarkers as surrogate endoscopic markers according to ulcerative colitis disease type2019
- Author(s)
  Sonoyama H, Kawashima K, Ishihara S, Kotani S, Fukuba N, Oka A, Kusunoki R, Tada Y, Mishima Y, Oshima N, Moriyama I, Yuki T, Onishi K, Kinoshita Y
- Journal Title
  
  J Clin Biochem Nutr
  
  Volume: in press
- NAID
  130007641427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07971
[Journal Article] Irritable Bowel Syndrome-Like Symptoms in Ulcerative Colitis Patients in Clinical Remission: Association with Residual Colonic Inflammation2018
- Author(s)
  Ishihara Shunji、Kawashima Kousaku、Fukuba Nobuhiko、Tada Yasumasa、Kotani Satoshi、Mishima Yoshiyuki、Oshima Naoki、Kinoshita Yoshikazu
- Journal Title
  
  Digestion
  
  Volume: 99 Issue: 1 Pages: 46-51
- DOI
  10.1159/000494412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09383, KAKENHI-PROJECT-18K07971
[Journal Article] Serum amyloid A level correlated with endoscopic findings in patients with Crohn’s disease?Possible biomarker for evaluating mucosal healing2018
- Author(s)
  Ishihara Shunji、Tada Yasumasa、Kawashima Kousaku、Kataoka Masatoshi、Sonoyama Hiroki、Yamashita Noritsugu、Oka Akihiko、Kusunoki Ryusaku、Fukuba Nobuhiko、Mishima Yoshiyuki、Oshima Naoki、Moriyama Ichiro、Yuki Takafumi、Kinoshita Yoshikazu
- Journal Title
  
  Digestive and Liver Disease
  
  Volume: 50 Issue: 6 Pages: 553-558
- DOI
  10.1016/j.dld.2017.12.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09383, KAKENHI-PROJECT-18K07971
[Presentation] 実臨床における難治性潰瘍性大腸炎に対するウステキヌマブの治療成績2021
- Author(s)
  川島　耕作　　大嶋　直樹　　岡　　明彦　　三島　義之　　石原　俊治
- Organizer
  第115回日本消化器病学会中国支部例会
- Data Source
  KAKENHI-PROJECT-21K07961
[Presentation] 感染後過敏性腸症候群におけるTLR9の関与の検討2020
- Author(s)
  三島義之，古谷聡史，川島耕作，石原俊治
- Organizer
  第16回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-18K07971
[Presentation] 潰瘍性大腸炎の治療目標は組織学的治癒か？－長期臨床的寛解維持予測における内視鏡的完全治癒と組織学的治癒の比較検討－2020
- Author(s)
  岡　　明彦、川島　耕作、園山　浩紀、三島　義之、石原　俊治
- Organizer
  第113回日本消化器病学会中国支部例会、山口
- Data Source
  KAKENHI-PROJECT-18K07971
[Presentation] Interleukin-33 delays recovery of mucosal inflammation by down-reguation of ABCG5/8 in colon2019
- Author(s)
  Mishima Y, Sonoyama H, Ishihara S, Oshima N, Moriyama I, Kawashima K, Kinoshita Y
- Organizer
  DDW2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07971
[Presentation] pH依存型メサラジン放出調節製剤投与後に心筋炎を発症した潰瘍性大腸炎の1例.2018
- Author(s)
  川島耕作、石原俊治、加藤輝士、片岡祐俊、古谷聡史、園山浩紀、三島義之、大嶋直樹、木下芳一
- Organizer
  第9回日本炎症性腸疾患学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07971
[Presentation] 組織学的所見に基づいた臨床的寛解潰瘍性大腸炎患者における過敏性腸症候群様症状の頻度に関する検討2018
- Author(s)
  川島耕作、石原俊治、福庭暢彦、片岡祐俊、山下詔嗣、園山浩紀、多田育賢、楠龍策、三島義之、大嶋直樹、結城崇史、木下芳一
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18K07971

1. Ishihara Shunji (80263531)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
2. 岡明彦 (80600600)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. Usuda Haruki (30707667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 玉木秀幸 (00421842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 和田孝一郎 (90263467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 古谷聡史 (60839067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大嶋直樹 (10403461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 川島耕作

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
9. 松本健次郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mishima Yoshiyuki 三島 義之

Research Projects

Research Products

Co-Researchers

潰瘍性大腸炎の難治化形成における消化管粘膜好酸球の解析と治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study regarding a novel anti-inflammatory eosinophil subset on pathogenesis of eosiophilic gastroenteritis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

感染後過敏性腸症候群におけるToll様受容体9-ブラジキニン経路の解明と治療応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of B cell functions regulating intestinal mucosal permeability on the pathogenesis of Crohn's disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study for intestinal archaea in human health and diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A challenge study to establish early diagnosis method for inflammatory bowel diseases by utilizing revolutionary quantifying method for intestinal barrier function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a novel mechanism leading regulatory B cells dysfunction of in Crohn's disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study of microbiota activated regulatory B cells in inflammatory bowel diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Low Fecal Calprotectin Predicts Histological Healing in Patients with Ulcerative Colitis with Endoscopic Remission and Leads to Prolonged Clinical Remission2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-lasting renal dysfunction following tacrolimus induction therapy in ulcerative colitis patients2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Intermittent Purpura Development Associated with Leukocytoclastic Vasculitis Induced by Infliximab for Crohn&apos;s Disease2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome2021

Author(s)

Mishima Yoshiyuki 三島義之

[Journal Article] Intermittent Purpura Development Associated with Leukocytoclastic Vasculitis Induced by Infliximab for Crohn's Disease2021