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Masaki Takao  正木 崇生

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MASAKI Takao  正木 崇生

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Researcher Number 30397913
Affiliation (Current) 2025: 広島大学, 病院(医), 教授
Affiliation (based on the past Project Information) *help 2015 – 2023: 広島大学, 病院(医), 教授
2013 – 2016: 広島大学, 大学病院, 教授
2014 – 2015: 広島大学病院, 教授
Review Section/Research Field
Principal Investigator
Basic Section 53040:Nephrology-related / Kidney internal medicine
Except Principal Investigator
Kidney internal medicine / Basic Section 53040:Nephrology-related / Gastroenterology
Keywords
Principal Investigator
間葉系幹細胞 / 抗炎症作用 / 線維化 / 再生医療 / マクロファージ / 腎線維化 / Epigenetic制御 / Na輸送体 / 免疫細胞浸潤 / 食塩感受性高血圧 … More / 生着 / 生着期間 / ステロイド / IFN-γ / 炎症細胞 / 治療効果 / 免疫抑制薬 / 老化 / ストレス誘導性老化 / 無血清培地 … More
Except Principal Investigator
線維化 / 腎線維化 / 急性腎障害 / エピジェネティクス / ヒストンバリアント / 糖尿病性腎症 / 抗炎症作用 / 虚血再灌流障害 / 腎硬化症 / 間葉系幹細胞 / DEC1 / 時計遺伝子 / マクロファージ / microRNA / TSG-6 / 細胞外小胞 / B cell lymphoma-2 / P53 / 低酸素 / survivin / p53 / 炎症細胞浸潤 / 生存率 / 心筋梗塞 / アポトーシス / ヒストン修飾 / 腎虚血再灌流障害 / 虚血再灌流 / アルドステロン / 食塩 / 上皮ナトリウムチャンネル / 食塩感受性高血圧 / ミネラルコルチコイドレセプター / エピジェネティック / HIRA / ヒストンシャペロン / H3.3 / ESKD / CKD / 高血圧 / 超音波療法 / ヒストンメチル化酵素 / ヒストンメチル化 / p16 / 老化 / Acute kidney injury / Senescence / p16INK4a / H3K4me3 / WDR5 / MLL1 / 阻害抗体 / 筋線維芽細胞 / 腎線維症 / 肝硬変 / α-smooth muscle actin / インテグリンα8β1 / 肺線維症 / TGF-β / 抗体医薬 / ノックアウトマウス / 肝線維症 / インテグリン / stellate cell / myofibroblast / integrin / antibody drug / fibrosis / 無血清培地 / 概日リズム / Na-K-ATPase / 日内変動 / CLOCK / 血圧 Less
  • Research Projects

    (13 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (15 People)
  •  間葉系幹細胞のEpigenetic制御によるNa輸送体変化を介した降圧効果Principal Investigator

    • Principal Investigator
      正木 崇生
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Hiroshima University
  •  Suppression of renal injury by extracellular vesicles from mesenchymal stem cells

    • Principal Investigator
      中島 歩
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      University of Yamanashi
  •  Effect of DEC1 on renal fibrosis and apoptosis induced by ischemia reperfusion injury

    • Principal Investigator
      Nakashima Ayumu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Hiroshima University
  •  Effect of mesenchymal stem cells on renal fibrosis: Combination with immunosuppressive therapyPrincipal Investigator

    • Principal Investigator
      Masaki Takao
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Hiroshima University
  •  Upregulation of mineralocorticoid receptor contributes to development of salt-sensitive hypertension after ischemic reperfusion injury in rats

    • Principal Investigator
      Doi Shigehiro
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Hiroshima University
  •  Supression of stress-induced senescene in kidney by transplantation of mesenchymal stem cellsPrincipal Investigator

    • Principal Investigator
      Masaki Takao
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Hiroshima University
  •  Inhibition of JMJD3 attenuate renal senescense in ischemic reperfusion mice

    • Principal Investigator
      Doi Shigehiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Hiroshima University
  •  Low-Intensity Pulsed Ultrasound Ameliorates Experimental Renal Fibrosis

    • Principal Investigator
      Nakashima Ayumu
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Hiroshima University
  •  TGF-beta promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA

    • Principal Investigator
      Kensuke Sasaki
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Hiroshima University
  •  A novel anti-integrin monoclonal antibody that attenuates mouse liver fibrosis: Mechanism of action and therapeutic application

    • Principal Investigator
      Yokosaki Yasuyuki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  Mesenchymal stem cells cultured in serum-free medium ameliorate experimental renal fibrosis.Principal Investigator

    • Principal Investigator
      MASAKI TAKAO
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Hiroshima University
  •  The role of clock genes in non-dipper hypertension

    • Principal Investigator
      Nakashima Ayumu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Hiroshima University
  •  The therapeutic effect of mesenchymal stem cells cultured under serum-free media on kidney diseases: to apply them to clinical application

    • Principal Investigator
      UENO TOSHINORI
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Hiroshima University

All 2019 2018 2017 2016 2015

All Presentation Patent

  • [Patent] 生体組織損傷の修復剤および当該修復剤の製造方法2016

    • Inventor(s)
      中島歩、正木崇生、土井盛博、吉田健、加藤幸夫、辻紘一郎
    • Industrial Property Rights Holder
      中島歩、正木崇生、土井盛博、吉田健、加藤幸夫、辻紘一郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-256779
    • Filing Date
      2016-12-28
    • Data Source
      KAKENHI-PROJECT-26461229
  • [Presentation] 間葉系幹細胞を用いた腎線維化抑制療法の開発2019

    • Author(s)
      中島歩、加藤幸夫、正木崇生
    • Organizer
      日本透析医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09699
  • [Presentation] Hypoxia-Preconditioned Mesenchymal Stem Cells Prevent AKI to CKD2019

    • Author(s)
      石内直樹、中島歩、土井盛博、金井亮、土井俊樹、正木崇生
    • Organizer
      American Society of Nephrology Kidney Week 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09699
  • [Presentation] Mesenchymal Stem Cells Cultured in IFN-γ-Containing Medium Ameliorate Experimental Renal Fibrosis2019

    • Author(s)
      金井亮、中島歩、土井盛博、石内直樹、土井俊樹、正木崇生
    • Organizer
      American Society of Nephrology Kidney Week 2019(
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09699
  • [Presentation] H3K4 Methyltransferase Inhibitor MM-102 Attenuates Renal Senescence in Ischemic Reperfusion Mice Through Reduction of p16INK4a2018

    • Author(s)
      Hironori Shimoda, Shigehiro Doi, Ayumu Nakashima, Kensuke Sasaki, Toshiki Doi, Takao Masaki
    • Organizer
      Annual Meeting of American Society of Nephrology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09618
  • [Presentation] H3K4メチル化酵素阻害剤MM-102は、p16INK4aの発現を抑制し、腎の炎症と線維化を改善する2018

    • Author(s)
      下田大紀、 土井盛博 、 土井俊樹 、 中島歩 、 正木崇生
    • Organizer
      日本腎臓学会
    • Data Source
      KAKENHI-PROJECT-16K09618
  • [Presentation] Mesenchymal stem cells cultured in serum-free medium ameliorate experimental renal fibrosis by their strong immunosuppressive effects2017

    • Author(s)
      吉田健、中島歩、土井盛博、上野敏憲、加藤幸夫、東幸仁、正木崇生
    • Organizer
      Kidney Week: American Society of Nephrology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09699
  • [Presentation] TGF-β1 promotes fibrotic gene expression through the induction of histone variant2017

    • Author(s)
      Toshihiro Shindo, Shigehiro Doi, Kensuke Sasaki, Ayumu Nakashima, Takao Masaki
    • Organizer
      ISN frontier
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19489
  • [Presentation] TGF-β1 promotes fibrotic gene expression through the induction of histone variant2017

    • Author(s)
      Toshihiro Shindo, Shigehiro Doi, Kensuke Sasaki, Ayumu Nakashima, Takao Masaki
    • Organizer
      米国腎臓学会2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19489
  • [Presentation] 時計遺伝子によるNa/K-ATPaseβ1を介した血圧日内変動の調節2015

    • Author(s)
      中島歩、正木崇生、土井盛博、東幸仁、加藤幸夫
    • Organizer
      日本腎臓学会
    • Place of Presentation
      名古屋:名古屋国際会議場
    • Year and Date
      2015-06-06
    • Data Source
      KAKENHI-PROJECT-25461248
  • 1.  Nakashima Ayumu (40448262)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 9 results
  • 2.  DOI Shigehiro (80626127)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 7 results
  • 3.  HIGASHI YUKIHITO (40346490)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 4.  Kensuke Sasaki (40770326)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 5.  KAWAMOTO TAKESHI (50224861)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  UENO TOSHINORI (50646891)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  Yokosaki Yasuyuki (80210607)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KATO YUKIO (10112062)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  茶山 一彰 (00211376)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  仙谷 和弘 (30508164)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  野間 玄督 (00379893)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  石内 直樹 (30898010)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TSUJINO KAZUYUKI
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  SHIMODA Hironori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  AIBARA Yoshiki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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