KURODA Itaru 黒田格

Researcher Number	30402051
Affiliation (based on the past Project Information) *help	2014: 山梨大学, 総合研究部, 医学研究員 2011: 山梨大学, 大学院・医学工学総合研究部, 医学研究員 2007 – 2008: 山梨大学, 医学部・附属病院, 医員 2005 – 2008: University of Yamanashi, University of Yamanashi Hospital, Medical Staff, 医学部附属病院, 医員
Review Section/Research Field	Except Principal Investigator Pediatrics / Biological Sciences
Keywords	Except Principal Investigator 白血病 / 細胞傷害因子 / 移植片対白血病効果 / TRAIL / 小胞体ストレス / 造血幹細胞移植 / 17;19転座 / アポトーシス / Ph1-positive leukemia / T-cell leukemia … More / 11q23 rearranged leukemia / GVL effect / endoplasmic reticulum-stress / cytotoxic ligands / apoptosis / leukemia / Fas / 同種造血幹細胞移植 / Ph1陽性白血病 / T細胞型急性リンパ性白血病 / 11q23転座型白血病 / BCR-ABL / Slug遺伝子 / 17 ; 19転座 / 転写因子 / 細胞死 / E2A-HLF / 細胞障害因子 / DR5受容体 / DR4 Less

Research for clinical application of cytotoxic ligands for graft-versus-leukemia effect against childhood leukemia
- Principal Investigator
  
  INUKAI Takeshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Clinical significance of cytotoxic factor-mediated graft-versus-leukemia effect against high-risk childhood leukemia
- Principal Investigator
  
  INUKAI Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Involvement of Slug transcription factor, a human homolog of ces-1 of C. elegans, in the regulation of apoptotic cell death of leukemia cells
- Principal Investigator
  
  INUKAI Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
細胞傷害因子の移植片対白血病効果における意義と臨床応用に向けた研究
- Principal Investigator
  
  INUKAI Takeshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
Anti-leukemic activity of cytotoxic ligands against poor-prognostic childhood leukemia
- Principal Investigator
  
  INUKAI Takeshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi

All 2013 2012 2011 2010 2009 2007 2006 2004 Other

All Journal Article Presentation

[Journal Article] BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia.2013
- Author(s)
  Kuroda I
- Journal Title
  
  Oncogene
  
  Volume: 32 Issue: 13 Pages: 1670-1681
- DOI
  10.1038/onc.2012.186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-24591544
[Journal Article] Endoplasmic reticulum stress inducers, but not imatinib, sensitize Philadelphia chromosome-positive leukemia cells to TRAIL-mediated apoptosis2011
- Author(s)
  Zhang X, Inukai T, Akahane K, Hirose K, Kuroda I, et al
- Journal Title
  
  Leuk Res
  
  Volume: 35 Pages: 940-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591356
[Journal Article] Resistance of T-cell acute lymphoblastic leukemia totumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis2010
- Author(s)
  Akahane K, Inukai T, Hirose K, Kuroda I, et al
- Journal Title
  
  Exp Hematol
  
  Volume: 38 Pages: 885-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591356
[Journal Article] Little impact of donor/recipient major mismatch for neutrophil-specific antigen NA2 on neutrophil recovery after allogeneic SCT2009
- Author(s)
  Inukai T, Goi K, Tezuka T, Uno K, Nemoto A, Takahashi K, Sato H, Akahane K, Hirose K, Honna H, Kuroda I, Kagami K, Nakamoto K, Taniguchi K, Nakazawa S, Sugita K.
- Journal Title
  
  Bone Marrow Transplant 43
  
  Pages: 229-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591246
[Journal Article] Fms-like tyrosine kinase 3 ligand stimulation induces MLL-rearranged leukemia cells into quiescence resistant to antileukemic agents2007
- Author(s)
  Furuichi Y, Goi K, Inukai T, Sato H, Nemoto A, Takahashi K, Akahane K, Hirose K, Honna H, Kuroda I, Zhang X, Kagami K, Hayashi Y, Harigaya K, Nakazawa S, Sugita K.
- Journal Title
  
  Cancer Res 67(29)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591246
[Journal Article] Revision of the cytological diagnosis of CNS relapse into aseptic meningitis in a patient with TEL-AMLI-positive acute lymphoblastic leukaemia by FISH analysis of mononuclear cells in cerebrospinal fluid2007
- Author(s)
  Inukai T, Akahane K, Kuroda I, Honna H, Sugita K, ら
- Journal Title
  
  Histopathology 50
  
  Pages: 947-949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18015020
[Journal Article] Revision of the cytological diagnosis of CNS relapse into aseptic meningitis in a patient with TEL-AML1-positive acute lymphoblastic leukaemia by FISH analysis of mononuclear cells in cerebrospinal fluid.2007
- Author(s)
  Inukai T, Akahane K, Kuroda I, Honna H, Sugita K, ら
- Journal Title
  
  Histopathology 50
  
  Pages: 947-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591246
[Journal Article] Fms-like Tyrosine Kinase 3 Ligand Stimulation Induces MLL-Rearranged Leukemia Cells into Quiescence Resistant to Antileukemic Agents.2007
- Author(s)
  Furuichi Y, Inukai T, Akahane K, Honna H, Kuroda I, Sugita K, ら
- Journal Title
  
  Cancer Res. 67
  
  Pages: 9852-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591246
[Journal Article] Revision of the cytological diagnosis of CNS relapse into aseptic meningitis in a patient with TEL-AML1-positive acute lymphoblastic leukaemia by FISH analysis of mononuclear cells in cerebrospinal fluid2007
- Author(s)
  Inukai T, Akahane K, Nemoto A, Kuroda I, Noguchi S, Hirose K, Honna H, Goi K, Kondo T, Iwasa S, Murata S, Kato R, Nakazawa S, Sugita K.
- Journal Title
  
  Histopathology 50(7)
  
  Pages: 947-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591246
[Journal Article] Fms-like Tyrosine Kinase 3 Ligand Stimulation Induces MLL-Rearranged Leukemia Cells into Quiescence Resistant to Antileukemic Agents2007
- Author(s)
  Furuichi Y, Inukai T, Akahane K, Honna H, Kuroda I, Sugita K, ら
- Journal Title
  
  Cancer Res. 67
  
  Pages: 9852-9861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18015020
[Journal Article] Natural pregnancy and delivery after allogeneic bone marrow transplantation in a Fanconi anaemia patient.2006
- Author(s)
  Goi K, Sugita K, Nakamura M, Inukai T, Honna H, Hirose K, Kuroda I, Hoshi K, Nakazawa S
- Journal Title
  
  British Journal of Haematology 135
  
  Pages: 410-411
- Data Source
  KAKENHI-PROJECT-18015020
[Journal Article] Non-T-cell-depleted HLA haploidentical stem cell transplantation based on feto-maternal microchimerism in pediatric patients with advanced malignancies.2004
- Author(s)
  Yoshihara T, Morimoto A, Inukai T, Kuroda H, Ishida H, Sugita K, Goi K, Imamura T, Todo S, Maruya E, Saji H, Nakazawa S, Imashuku S.
- Journal Title
  
  Bone Marrow Transplant. 34(4)
  
  Pages: 373-375
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591017
[Journal Article] Oncogenic fusion E2A-HLF sensitize t(17 ; 19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors
- Author(s)
  Zhang X, Inukai T, Hirose K, Akahane K, Kuroda I, et al
- Journal Title
  
  Leukemia
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591356
[Journal Article] BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand(TRAIL) in Philadelphia chromosome-positive leukemia
- Author(s)
  Kuroda I, Inukai T, Akahane K, Hirose K, et al
- Journal Title
  
  Oncogene
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591356
[Presentation] 骨髄低酸素環境におけるPh+白血病細胞の抗がん剤耐性とHIF-1αの関与2013
- Author(s)
  黒田格, 犬飼岳史ら
- Organizer
  第55回日本小児血液・がん学会学術集会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-24591544
[Presentation] BCR-ABL regulates death receptor expression for TRAIL in Ph+ leukemia2012
- Author(s)
  Kuroda Itaru, Inukai Takeshi, Kikuchi Jiro, Furukawa Yusuke, et al.
- Organizer
  日本血液学会
- Place of Presentation
  京都国際会館（京都市）
- Data Source
  KAKENHI-PROJECT-24591544
[Presentation] TRAIL-sensitivity of Ph-positive leukemia cells in low oxygen environment corresponding to bone marrow2012
- Author(s)
  Somazu Shinpei, Kuroda Itaru, Watanabe Atushi, Inukai Takeshi, et al
- Organizer
  日本小児血液・がん学会学術集会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-24591544
[Presentation] BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand(TRAIL) inPhiladelphia chromosome-positive leukemia2011
- Author(s)
  Kuroda I, Inukai T, Akahane K, HiroseK, et al
- Organizer
  53th American Society of Hematology Annual Meeting
- Place of Presentation
  San Diego
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-21591356
[Presentation] BCR-ABL Regulates Death Receptor Expression for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Philadelphia Chromosome-Positive Leukemia2011
- Author(s)
  Kuroda I, Inukai T, et al
- Organizer
  アメリカ血液学会
- Place of Presentation
  サンディェゴ国際会議場(アメリカ合衆国)
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-21591356
[Presentation] T細胞型急性リンパ性白血病のTRAIL耐性へのTRAIL受容体DR4/DR5遺伝子のメチル化とプロモーター活性の関与2009
- Author(s)
  赤羽弘資,犬飼岳史,廣瀬衣子,黒田格, ほか
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21591356
[Presentation] BCR-ABLはPh1陽性白血病細胞のTRAILに対するdeath受容体の発現に関与する2009
- Author(s)
  黒田格,犬飼岳史,張暁春,廣瀬衣子,赤羽弘資, ほか
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21591356
[Presentation] Philadelphia染色体陽性白血病細胞におけるImatinibによる小胞体ストレス誘導作用とTRAIL感受性の検討2009
- Author(s)
  張暁春,犬飼岳史,黒田格,赤羽弘資,廣瀬衣子, ほか
- Organizer
  第51回日本小児血液学会総会
- Place of Presentation
  幕張
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21591356

1. INUKAI Takeshi (30293450)

# of Collaborated Projects: 5 results

# of Collaborated Products: 21 results
2. HIROSE Kinuko (70436880)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
3. AKAHANE Koshi (90377531)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. GOI Kumiko (70324192)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. 本名浩子 (50377537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. NEMOTO Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KURODA Itaru 黒田 格

Research Projects

Research Products

Co-Researchers

Research for clinical application of cytotoxic ligands for graft-versus-leukemia effect against childhood leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical significance of cytotoxic factor-mediated graft-versus-leukemia effect against high-risk childhood leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of Slug transcription factor, a human homolog of ces-1 of C. elegans, in the regulation of apoptotic cell death of leukemia cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞傷害因子の移植片対白血病効果における意義と臨床応用に向けた研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Anti-leukemic activity of cytotoxic ligands against poor-prognostic childhood leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endoplasmic reticulum stress inducers, but not imatinib, sensitize Philadelphia chromosome-positive leukemia cells to TRAIL-mediated apoptosis2011

Author(s)

Journal Title

Data Source

[Journal Article] Resistance of T-cell acute lymphoblastic leukemia totumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis2010

Author(s)

Journal Title

Data Source

[Journal Article] Little impact of donor/recipient major mismatch for neutrophil-specific antigen NA2 on neutrophil recovery after allogeneic SCT2009

Author(s)

Journal Title

Data Source

[Journal Article] Fms-like tyrosine kinase 3 ligand stimulation induces MLL-rearranged leukemia cells into quiescence resistant to antileukemic agents2007

Author(s)

Journal Title

Data Source

[Journal Article] Revision of the cytological diagnosis of CNS relapse into aseptic meningitis in a patient with TEL-AMLI-positive acute lymphoblastic leukaemia by FISH analysis of mononuclear cells in cerebrospinal fluid2007

Author(s)

Journal Title

Data Source

[Journal Article] Revision of the cytological diagnosis of CNS relapse into aseptic meningitis in a patient with TEL-AML1-positive acute lymphoblastic leukaemia by FISH analysis of mononuclear cells in cerebrospinal fluid.2007

Author(s)

Journal Title

Data Source

[Journal Article] Fms-like Tyrosine Kinase 3 Ligand Stimulation Induces MLL-Rearranged Leukemia Cells into Quiescence Resistant to Antileukemic Agents.2007

Author(s)

Journal Title

Data Source

[Journal Article] Revision of the cytological diagnosis of CNS relapse into aseptic meningitis in a patient with TEL-AML1-positive acute lymphoblastic leukaemia by FISH analysis of mononuclear cells in cerebrospinal fluid2007

Author(s)

Journal Title

Data Source

[Journal Article] Fms-like Tyrosine Kinase 3 Ligand Stimulation Induces MLL-Rearranged Leukemia Cells into Quiescence Resistant to Antileukemic Agents2007

Author(s)

Journal Title

Data Source

[Journal Article] Natural pregnancy and delivery after allogeneic bone marrow transplantation in a Fanconi anaemia patient.2006

Author(s)

Journal Title

Data Source

[Journal Article] Non-T-cell-depleted HLA haploidentical stem cell transplantation based on feto-maternal microchimerism in pediatric patients with advanced malignancies.2004

KURODA Itaru 黒田格