HOSOGI Shigekuni 細木誠之

… Alternative Names

細木誠之ホソギシゲクニ

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Researcher Number	30405261
Affiliation (based on the past Project Information) *help	2014: 京都府立医科大学, 医学研究科, 助教 2011: 京都府立医科大学, 医学研究科, 助教 2008 – 2009: 京都府立医科大学, 医学研究科, 助教
Review Section/Research Field	Except Principal Investigator General physiology / Respiratory organ internal medicine
Keywords	Except Principal Investigator インスリン抵抗性 / 組織間質液 / 糖尿病 / pH / 肺水腫 / シグナリングアッセイ / アポトーシス / 肺胞上皮 / CD14 / エンドトキシン肺損傷 … More / TLR / 腎皮質集合管 / アルドステロン / 透浸圧 / ナトリウム輸送 / 高血圧 / トラッフィッキング / 浸透圧 / プロテアーゼ阻害剤 / 皮質集合管 / アルデステン / ENaC Less

Continuous pH measurement of interstitial fluid and clarification of pathogenic mechanism of insulin resistance by ISFET pH sensor
- Principal Investigator
  
  MARUNAKA Yoshinori
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Kyoto Prefectural University of Medicine
Regulation of intracellular localization of ENaC by protease
- Principal Investigator
  
  MARUNAKA Yoshinori
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Kyoto Prefectural University of Medicine
TLR gene expression in e ndotoxin-induced lung injury
- Principal Investigator
  
  IWASAKI Yoshinobu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine

All 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Other

[Journal Article] Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats2014
- Author(s)
  Yoshinori Marunaka, Kanji Yoshimoto, Wataru Aoi, Shigekuni Hosogi, Hiroshi Ikegaya
- Journal Title
  
  Molecular and Cellular Therapies
  
  Volume: 2:6 Issue: 1 Pages: 1-4
- DOI
  10.1186/2052-8426-2-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25282199, KAKENHI-PROJECT-25670111
[Journal Article] Cytosolic chloride ion is a key factor in lysosomal acidification and function of autophagy in human gastric cancer cell2014
- Author(s)
  Hosogi S, Kusuzaki K, Inui T, Wang X, MARUNAKA Y
- Journal Title
  
  J Cell Mol Med
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670111
[Journal Article] A regulatory role of K^+-Cl^- cotransporter in the cell cycle progression of breast cancer MDA-MB-231 cells.2013
- Author(s)
  Kitagawa M, Niisato N, Shiozaki A, Ohta-Fujimoto M, Hosogi S, Miyazaki H, Ichikawa D, Otsuji E, Marunaka Y.
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 539巻 Issue: 1 Pages: 92-98
- DOI
  10.1016/j.abb.2013.06.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J03299, KAKENHI-PROJECT-24590283, KAKENHI-PROJECT-25460297, KAKENHI-PROJECT-25670111
[Journal Article] Regulation of epithelial sodium transport via epithelial Na^+channel(ENaC)2011
- Author(s)
  MARUNAKA Y, Niisato N, Taruno A, Ohta M, Miyazaki H, Hosogi S, Nakajima K, Kusuzaki K, Ashihara E, Nishio K, Iwasaki Y, Nakahari T, Kubota T
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: 2011 Pages: 978196-978196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390060
[Journal Article] Regulation of epithelial sodium transport via epithelial Na^+ channel (ENaC)2011
- Author(s)
  Marunaka Y, Niisato N, Taruno A, Ohta M, Miyazaki H, Hosogi S, Nakajima K, Kusuzaki K, Ashihara E, Nishio K, Iwasaki Y, Nakahari T, Kubota T
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: 2011 Issue: 1 Pages: 978196-978196
- DOI
  10.1155/2011/978196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390060, KAKENHI-PROJECT-21590243, KAKENHI-PROJECT-22790215
[Journal Article] Photodynamic therapy with acridine orangein musculoskeletal sarcomas.2010
- Author(s)
  Matsubara T, Kusuzaki K, Matsumine A, Murata H, Marunaka Y, Hosogi S, Uchida A, Sudo A.
- Journal Title
  
  J Bone Joint Surg (Br).
  
  Volume: 92(6) Pages: 760-762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390060
[Journal Article] Photodynamic therapy with acridine orange in musculoskeletal sarcomas.2010
- Author(s)
  Matsubara T, Kusuzaki K, Matsumine A, Murata H, Marunaka Y, Hosogi S, Uchida A, Sudo A.
- Journal Title
  
  J Bone Joint Surg Br.
  
  Volume: 92(6) Pages: 760-762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390060
[Journal Article] Regulation of paracellular Na^+and Cl^-conductances by hydrostatic pressure2009
- Author(s)
  Tokuda S, Niisato N, Nagai T, Taruno A, Nakajima K, Miyazaki H, Yamada T, Hosogi S, Ohta M, Nishio K, Iwasaki Y, MARUNAKA Y
- Journal Title
  
  Cell Biol Int
  
  Volume: 33 Pages: 949-956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390060
[Journal Article] Regulation of paracellular Na+ and Cl(-) conductances by hydrostatic pressure2009
- Author(s)
  Tokuda S, Niisato N, Nagai T, Taruno A, Nakajima K, Miyazaki H, Yamada T, Hosogi S, Ohta M, Nishio K, Iwasaki Y, Marunaka Y.
- Journal Title
  
  Cell Biol Int. 33(9)
  
  Pages: 949-956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390060
[Journal Article] Regulation of paracellular Na+ and Cl- conductances by hydrostatic pressure.2009
- Author(s)
  Tokuda S, Niisato N, Nagai T, Taruno A, Nakajima K, Miyazaki H, Yamada T, Hosogi S, Ohta M, Nishio K, Iwasaki Y, MARUNAKA Y.
- Journal Title
  
  Cell Biol Int 33
  
  Pages: 949-956
- Data Source
  KAKENHI-PROJECT-20390060
[Journal Article] Phase II trial of weekly gemcitabine and split-dose cisplatin for advanced non-small-cell lung cancer.2009
- Author(s)
  Hiramatsu A, Iwasaki Y, Koyama Y, Tamiya N, Hosogi S, Nakanishi M, Kohno Y, Ueda M, Arimoto T, Marunaka Y.
- Journal Title
  
  Jpn J Clin Oncol 39(12)
  
  Pages: 779-783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390060
[Journal Article] Phase II trial of weekly gemcitabine and split-dose cisplatin for advanced non-small-cell lung cancer.2009
- Author(s)
  HIRAMATSU ATSUSHI, IWASAKI YOSHINOBU, KOYAMA YASUNORI, TAMIYA NOBUYO, HOSOGI SHIGEKUNI, NAKANISHI MASAKI, KOHNO YOSHIHITO, UEDA MIKIO, ARIMOTO TAICHIRO, MARUNAKA YOSHINORI
- Journal Title
  
  Jpn J Clin Oncol 39(12)
  
  Pages: 779-783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590932
[Journal Article] Two cases of complex sleep apnea syndrome.2009
- Author(s)
  Yamada T, Arimoto T, Koyama Y, Masui A, Tamiya N, Hosogi S, Hiramatu A, Nakanishi M, Kohno Y, Ueda M, Iwasaki Y, Marunaka Y.
- Journal Title
  
  Nihon Kokyuki Gakkai Zasshi 47(9)
  
  Pages: 793-797
- NAID
  10026272278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390060
[Journal Article] Effect of inducible nitric oxide synthase on apoptosis in Candida-induced acute lung iniury.2008
- Author(s)
  HOSOGI SHIGEKUNI
- Journal Title
  
  Biomedical Research 29・5
  
  Pages: 10-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590932
[Journal Article] Effect of inducible nitric oxide synthase on apoptosis2008
- Author(s)
  HOSOGI SHIGEKUNI, IWASAKI YOSHINOBU, YAMADA TAKAHIRO, KOMATANI-TAMIYA NOBUYO, HIRAMATSU ATSUSHI, KOHNO YOSHIHITO, UEDA MIKIO, ARIMOTO TAICHIRO, MARUNAKA YOSHINORI
- Journal Title
  
  Candida-induced acute lung injury 29
  
  Pages: 257-266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590932
[Journal Article] Effect of inducible nitric oxide synthase on apoptosis in Candia-inducedacute lung injury2008
- Author(s)
  Hosogi S, Iwasaki, Yamada T, Komatani-Tamiya, Hiramatsu A, Kohno Y, Ueda M, Arimoto T, MARUNAKA Y
- Journal Title
  
  Biomed. Res. 29
  
  Pages: 257-266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390060
[Presentation] Cytosolic chloride ion is a key factor in lysosomal acidification and function of autophagy in human gastric cancer cell.2014
- Author(s)
  Hosogi S, Miyazaki H, Kusuzaki K, Niisato N, MARUNAKA Y.
- Organizer
  The Physiological Society of Japan
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-25670111
[Presentation] Regulation of lysosomal pH and autophagy by cytosolic chloride ions2013
- Author(s)
  Hosogi S, MARUNAKA Y
- Organizer
  Japan-Italy Joint Symposium on "Ionic Dynamics in Normal and Tumor Tissues
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-25670111
[Presentation] What is the role of interstitial pH in diabetes mellitus? Improving action of propolis on DM symptom via pH regulation2013
- Author(s)
  MARUNAKA Y, Aoi W, Hosogi S, Niisato N, Yokoyama N, Hayata H, Miyazaki H, Kusuzaki K, Taruno A, Nomura T.
- Organizer
  The 16th International Symposium on Molecular Medicine
- Place of Presentation
  Creta Maris, Hersonissos, Crete, Greece
- Invited
- Data Source
  KAKENHI-PROJECT-25670111
[Presentation] Action of quercetin on cell Function via regulation of chloride ion transport.2013
- Author(s)
  MARUNAKA Y, Niisato N, Miyazaki H, Nakajima K, Hosogi S, Tarnu A, Yokoyama N
- Organizer
  The 13th International Conference on Functional and Medical Foods with Bioactive Compounds: Science and Practice
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-25670111
[Presentation] The mechanisms of Na^+/H^+ exchanger inhibitor on proliferation of gastric cancer cells with several pathways2012
- Author(s)
  Hosogi Shigekuni, Ohta Mariko, Nakajima Ken-ichi, Ashihara Eishi, Niisato Naomi, Marunaka Yoshinori
- Organizer
  The 89^<th> Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Matsumoto
- Data Source
  KAKENHI-PROJECT-20390060
[Presentation] An inhibitor of Na^+/H^+ exchanger (NHE), ethyl-isopropyl amiloride (EIPA), diminishes proliferation of MKN28 human gastric cancer cells by decreasing the intracellular Cl^- concentration via DIDS-sensitive pathway2011
- Author(s)
  Hosogi S, Ashihara E, Niisato N, Kusuzaki K, Marunaka Y
- Organizer
  The 2nd Symposium of the International Society for Proton Dynamics in Cancer 2011
- Place of Presentation
  Nice
- Data Source
  KAKENHI-PROJECT-20390060
[Presentation] 胃癌細胞株MKN-28細胞株のおけるNa+/H+ exchanger (NHE)阻害剤の細胞内pH・Cl-濃度の与える影響と細胞増殖抑制機構2011
- Author(s)
  細木誠之、太田麻利子、中島謙一、宮崎裕明、芦原英司、楠崎克之、新里直美、丸中良典
- Organizer
  日本生理学会第104回近畿生理学談話会
- Place of Presentation
  大阪
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-20390060
[Presentation] クロライドイオン輸送体活性化による神経突起伸長促進機構の解明2011
- Author(s)
  丸中良典、楠崎克之、新里直美、芦原英司、中島謙一、細木誠之、羽柴光起
- Organizer
  ソルト・サイエンス研究財団第23回助成研究発表会
- Place of Presentation
  東京
- Year and Date
  2011-07-19
- Data Source
  KAKENHI-PROJECT-20390060
[Presentation] Na^+/H^+ exchanger isoform 1(NHE-1)-dependent proliferation of gastric cancer cells2010
- Author(s)
  Hosogi S, Nakajima K, Miyazaki H, Niisato N, Marunaka Y.
- Organizer
  The 87^<th> Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Morioka
- Data Source
  KAKENHI-PROJECT-20390060
[Presentation] Translational research of photodynamic therapy with acridine orange which targets acidic vesicles and environment of cancer cells.2010
- Author(s)
  Kusuzaki K, Hosogi S, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Sudo A, Marunaka Y.
- Organizer
  The 1^<st> Symposium of the International Society for Proton Dynamics in Cancer.
- Place of Presentation
  Rome
- Data Source
  KAKENHI-PROJECT-20390060
[Presentation] Na^+/H^+ exchanger isoform 1 (NHE-1)-dependent proliferation of gastric cancer cells.2010
- Author(s)
  Hosogi S, Kusuzaki K, Niisato N, Marunaka Y.
- Organizer
  The 1^<st> Symposium of the International Society for Proton Dynamics in Cancer.
- Place of Presentation
  Rome
- Data Source
  KAKENHI-PROJECT-20390060
[Presentation] Morphological alterations of cell membrane during apoptosis induced by photodynamic therapy with acridine orange.2010
- Author(s)
  Kusuzaki K, Hosogi S, Ashihara E, Nakajima K, Niisato N, Marunaka Y.
- Organizer
  Membrane Symposium 2010
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20390060
[Presentation] SODIUM HYDROGEN EXCHANGER ISOFORM1 (NHE-1)-DEPENDENT PROLIFERATION OF GASTRIC CANCER CELLS.2009
- Author(s)
  Hosogi S, Takemura Y, Miyazaki H, Niisato N, Iwasaki Y, Marunaka Y.
- Organizer
  36TH INTERNATIONAL CONGRESS OF PHYSIOLOGICAL SCIENCES.
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20390060
[]

1. MARUNAKA Yoshinori (00127036)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
2. NIISATO Naomi (00237645)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
3. MIYAZAKI Hiroaki (30360027)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. HOSOGI Shigekuni (30433254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKAJIMA Ken-ichi (40398392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. KUSUZAKI Katsuyuki (30177993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
7. ASHIHARA Eishi (70275197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. IWASAKI Yoshinobu (00203373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. ARIMOTO Taichiro (30457965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. UEDA Mikio (40457966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. HIDESHIMA Sho (10580433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山田敏樹 (10453101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. 青井渉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HOSOGI Shigekuni 細木 誠之

細木 誠之 ホソギ シゲクニ

Research Projects

Research Products

Co-Researchers

Continuous pH measurement of interstitial fluid and clarification of pathogenic mechanism of insulin resistance by ISFET pH sensor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of intracellular localization of ENaC by protease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TLR gene expression in e ndotoxin-induced lung injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytosolic chloride ion is a key factor in lysosomal acidification and function of autophagy in human gastric cancer cell2014

Author(s)

Journal Title

Data Source

[Journal Article] A regulatory role of K^+-Cl^- cotransporter in the cell cycle progression of breast cancer MDA-MB-231 cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of epithelial sodium transport via epithelial Na^+channel(ENaC)2011

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of epithelial sodium transport via epithelial Na^+ channel (ENaC)2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Photodynamic therapy with acridine orangein musculoskeletal sarcomas.2010

Author(s)

Journal Title

Data Source

[Journal Article] Photodynamic therapy with acridine orange in musculoskeletal sarcomas.2010

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of paracellular Na^+and Cl^-conductances by hydrostatic pressure2009

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of paracellular Na+ and Cl(-) conductances by hydrostatic pressure2009

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of paracellular Na+ and Cl- conductances by hydrostatic pressure.2009

Author(s)

Journal Title

Data Source

[Journal Article] Phase II trial of weekly gemcitabine and split-dose cisplatin for advanced non-small-cell lung cancer.2009

Author(s)

Journal Title

Data Source

[Journal Article] Phase II trial of weekly gemcitabine and split-dose cisplatin for advanced non-small-cell lung cancer.2009

Author(s)

Journal Title

Data Source

[Journal Article] Two cases of complex sleep apnea syndrome.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Effect of inducible nitric oxide synthase on apoptosis in Candida-induced acute lung iniury.2008

HOSOGI Shigekuni 細木誠之

細木誠之ホソギシゲクニ