Shimono Kazumi 下野和実

… Alternative Names

SHIMONO Kazumi 下野和実

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Researcher Number	30415187
Other IDs
Affiliation (Current)	2025: 崇城大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 崇城大学, 薬学部, 教授 2012 – 2013: 東邦大学, 薬学部, 准教授 2008 – 2011: Matsuyama University, 薬学部, 助教 2007: The Institute of Physical and Chemical Research, タンパク質基盤研究グループ, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Physical pharmacy / Biophysics
Keywords	Principal Investigator 多剤排出輸送担体 / 等温滴定型熱量計 / 水分子 / 多剤認識 / エントロピー / トランスポーター / 合理的医薬品設計 / 疎水性相互作用 / 脱水和エントロピー / エンタルピーエントロピー補償則 … More / 多剤認識機構 / YdgR / EmrE / alternative access model / 無細胞タンパク質合成系 / 薬物輸送担体 / 熱力学量 / プロトン/オリゴペプチド輸送担体 / 相互作用エネルギー / 分子認識 / 薬物輸送 / 非天然アミノ酸導入 / 部位特異的ラベル / フォールディング / バクテリオロドプシン / リボソーム / 光誘起プロトン移動 / 界面活性剤 / キサントロドプシン / リポソーム / 無細胞タンパク質合成 / 光受容膜タンパク質 / ロドプシン / フォトサイクル / 脂質二重膜 / ステロイド系界面活性剤 / 大量発現 / 膜タンパク質 Less

Basic research on thermodynamics-based drug design of multi drug efflux transporter inhibitorsPrincipal Investigator
- Principal Investigator
  
  Shimono Kazumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Sojo University
Thermodynamics-based mechanism for the regulation of substrate binding affinity of proton coupled drug transportersPrincipal Investigator
- Principal Investigator
  
  SHIMONO Kazumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Toho University
  Matsuyama University
Development of Expression System for Photoreceptor Using Cell-free Protein Synthesis and Application of Its system for Their Functional AnalysisPrincipal Investigator
- Principal Investigator
  
  SHIMONO Kazumi
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Matsuyama University
  The Institute of Physical and Chemical Research

All 2022 2021 2020 2019 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book Patent

[Book] オプトジェネティックスー光工学と遺伝学による行動制御技術の最前線―2013
- Author(s)
  下野和実
- Total Pages
  288
- Publisher
  株式会社エヌティーエス
- Data Source
  KAKENHI-PROJECT-23790060
[Book] オプトジェネティックスー光工学と遺伝学による行動制御技術の最前線—;第1編第2章第1節"調製困難なロドプシン類の機能的大量合成法"2013
- Author(s)
  下野和実
- Total Pages
  324
- Publisher
  株式会社エヌティーエス
- Data Source
  KAKENHI-PROJECT-23790060
[Book] Photo-induced proton transfers of microbial rhodopsins. Molecular Photochemistry - Various Aspects2012
- Author(s)
  Kikukawa, T., Tamogami, J., Shimono, K., Demura, M., Nara, T., Kamo, N
- Total Pages
  282
- Publisher
  Book edited by Dr. Satyen Saha(DOI; 10.5772/34105)
- Data Source
  KAKENHI-PROJECT-23790060
[Book] Molecular Photochemistry - Various Aspects (Book edited by Dr. Satyen Saha) Chapter 5 "Photo-induced proton transfers of microbial rhodopsins."2012
- Author(s)
  Kikukawa, T., Tamogami, J., Shimono, K., Demura, M., Nara, T., Kamo, N.
- Publisher
  Intech
- Data Source
  KAKENHI-PROJECT-23790060
[Journal Article] Estimation of the Diffusion Coefficients of Small Molecules by Diffusion Measurements with Agar-gel and Theoretical Molecular Modeling2022
- Author(s)
  Miyamoto Shuichi、Shimono Kazumi
- Journal Title
  
  Chem-Bio Informatics Journal
  
  Volume: 22 Issue: 0 Pages: 13-20
- DOI
  10.1273/cbij.22.13
- ISSN
  1347-0442, 1347-6297
- Year and Date
  2022-04-30
- Language
  English
- Data Source
  KAKENHI-PROJECT-19K07549
[Journal Article] Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity2021
- Author(s)
  Akiko Omori, Yuki Fujisawa, Shotaro Sasaki, Kazumi Shimono, Takashi Kikukawa, Seiji Miyauchi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 5 Pages: 678-685
- DOI
  10.1248/bpb.b20-01013
- NAID
  130008033231
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-05-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06608, KAKENHI-PROJECT-18K14962, KAKENHI-PROJECT-19K07549
[Journal Article] Molecular Modeling to Estimate the Diffusion Coefficients of Drugs and Other Small Molecules2020
- Author(s)
  Miyamoto Shuichi、Shimono Kazumi
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 22 Pages: 5340-5340
- DOI
  10.3390/molecules25225340
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07549
[Journal Article] A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility2014
- Author(s)
  Sakiyama, M.　Matsuo, H.　Shimizu, S.　Chiba, T.　Nakayama, A.　Takada, Y.　Nakamura, T.　Takada, T.　Morita, E.　Naito, M.　Wakai, K.　Inoue, H.　Tatsukawa, S.　Sato, J.　Shimono, K.　Makino, T.　Satoh, T.　Suzuki, H.　Kanai, Y.　Hamajima, N.　Sakurai, Y.　Ichida, K.　Shimizu, T.　Shinomiya, N.
- Journal Title
  
  Hum Cell
  
  Volume: 27(1) Issue: 1 Pages: 1-4
- DOI
  10.1007/s13577-013-0081-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300365, KAKENHI-PROJECT-23591205, KAKENHI-PROJECT-23790060, KAKENHI-PROJECT-24390217, KAKENHI-PROJECT-25293145, KAKENHI-PROJECT-25461719, KAKENHI-PROJECT-221S0001
[Journal Article] A study of the interaction of drugs with liposomes with isothermal titration calorimetry2013
- Author(s)
  Osanai H, Ikehara T, Miyauchi S1, Shimono K, Tamogami J, Nara T, Kamo N
- Journal Title
  
  Journal of Biophysical Chemistry
  
  Volume: 4 Issue: 01 Pages: 11-21
- DOI
  10.4236/jbpc.2013.41002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590062, KAKENHI-PROJECT-23790060
[Journal Article] Thermodynamic parameters of anion binding to halorhodopsin from Natronomonas pharaonis by isothermal titration calorimetry2013
- Author(s)
  Hayashi, Saori
- Journal Title
  
  Biophysical Chemistry
  
  Volume: 172 Pages: 61-67
- DOI
  10.1016/j.bpc.2013.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049, KAKENHI-PROJECT-23510251, KAKENHI-PROJECT-23590062, KAKENHI-PROJECT-23657096, KAKENHI-PROJECT-23790060
[Journal Article] Photoinduced proton release in proteorhodopsin at low pH: The possibility of a decrease in the pKa of Asp2272012
- Author(s)
  Tamogami Jun, Kikukawa Takashi, NaraToshifumi , Shimono Kazumi, Demura Makoto, Kamo Naoki
- Journal Title
  
  Biochemistry
  
  Volume: 51巻 Issue: 46 Pages: 9290-9301
- DOI
  10.1021/bi300940p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049, KAKENHI-PROJECT-23510251, KAKENHI-PROJECT-23657096, KAKENHI-PROJECT-23790060
[Journal Article] Photochemistry of a Putative New Class of Sensory Rhodopsin (SRIII) coded by xop2 of Haloarcular marismortui2011
- Author(s)
  Nakao, Y., Kikukawa, T., Shimono, K., 他6名
- Journal Title
  
  Journal of Photochemistry and Photobiology B
  
  Volume: 102 Pages: 45-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] Photochemistry of a Putative New Class of Sensory Rhodopsin (SRIII) coded by xop2 of Haloarcular marismortu2011
- Author(s)
  Nakao, Y., Kikukawa,T., Shimono, K., Tamogami, J., Kimitsuki, N., Nara, T., Unno, M., Ihara, K., Kamo, N.
- Journal Title
  
  Journal of Photochemistry and Photobiology B 102
  
  Pages: 45-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] 無細胞タンパク質合成による膜タンパク質の生産2011
- Author(s)
  下野和実, 白水美香子, 横山茂之
- Journal Title
  
  生物物理 51(3)
  
  Pages: 128-129
- NAID
  10029139965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] Photochemistry of acetabularia rhodopsin II from a marine plant, Aceta bularia acetabulum2011
- Author(s)
  Kikukawa Takashi
- Journal Title
  
  Biochemistry
  
  Volume: 50 Issue: 41 Pages: 8888-8898
- DOI
  10.1021/bi2009932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049, KAKENHI-PROJECT-23510251, KAKENHI-PROJECT-23590062, KAKENHI-PROJECT-23790060
[Journal Article] Crystal structure of the Eukaryotic light-driven proton-pumping rhodopsin, Acetabularia rhodopsin II from Marine Algae2011
- Author(s)
  Wada Takashi
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 411 Issue: 5 Pages: 986-998
- DOI
  10.1016/j.jmb.2011.06.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590049, KAKENHI-PROJECT-23510251, KAKENHI-PROJECT-23790060
[Journal Article] 無細胞タンパク質合成系を活用した膜タンパク質合成方法2010
- Author(s)
  下野和実, 白水美香子, 横山茂之
- Journal Title
  
  実験医学
  
  Volume: 28(11) Pages: 1775-1780
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] 無細胞タンパク質合成系を活用した膜タンパク質合成法の開発2010
- Author(s)
  下野和実, 白水美香子, 横山茂之
- Journal Title
  
  BIO INDUSTRY
  
  Volume: 27(6) Pages: 55-63
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] 無細胞タンパク質合成系を活用した膜タンパク質合成法の開発2010
- Author(s)
  下野和実, 白水美香子, 横山茂之
- Journal Title
  
  BIOINDUSTRY 27
  
  Pages: 55-63
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] 無細胞タンパク質合成系を活用した膜タンパク質合成方法2010
- Author(s)
  下野和実, 白水美香子, 横山茂之
- Journal Title
  
  実験医学 28(11)
  
  Pages: 1775-1780
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] Production of functional bacteriorhodopsin by an Escherichia coli cell-free protein synthesis system supplemented with steroid detergent and lipid2009
- Author(s)
  Kazumi Shimono, 他6名
- Journal Title
  
  Protein Science 18
  
  Pages: 2160-2171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] Production of functional bacteriorhodopsin by an Escherichia coli cell-free protein synthesis system supplemented with steroid detergent and lipid2009
- Author(s)
  Shimono, K., Goto, M., Kikukawa, T., Miyauchi, S., Shirouzu, M., Kamo, N., Yokoyama S.
- Journal Title
  
  Protein Science 18
  
  Pages: 2160-2171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] Production of functional bacteriorhodopsin by an Escherichia coli cell-free protein synthesis system supplemented with steroid detergent and lipid2009
- Author(s)
  Kazumi Shimono, Mie Goto, Takashi Kikukawa, Seiji Miyauchi, Mikako Shirouzu, Naoki Kamo, Shigeyuki Yokoyama
- Journal Title
  
  Protein Science 18
  
  Pages: 2160-2171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] Functional overexpression of SMR-type multidrug transporter using cell-free protein synthesis system and analysis of interaction between transporter and its substrates by isothermal titration calorimetry2008
- Author(s)
  Shimono, K., Kikukawa, T., Nara, T., Someya, T., Shirouzu, M., Yokoyama, S., Miyauchi, S.
- Journal Title
  
  Yakugaku Zasshi Journal of The Pharmaceutical Society of Japan, (Suppl.2) 128
  
  Pages: 139-140
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] A long-lived M-like state of phoborhodopsin that mimics the active state2008
- Author(s)
  Sudo, Y., Nishihori, T., Iwamoto, M., Shimono, K., Kojima, C., Kamo, N.
- Journal Title
  
  Biophysical Journal 95(2)
  
  Pages: 753-760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770136
[Journal Article] Participation of the surface structure of Pharaonis phoborhodopsin, ppR and its A149S and A149V mutants, consisting of the C-terminal alpha-helix and E-F loop, in the complex-formation with the cognate transducer pHtrII, as revealed by site-directed C-13 solid-state NMR2007
- Author(s)
  Kawamura, I., Ikeda, Y., Sudo, Y., Iwamoto, M., Shimono, K., Yamaguchi, S., Tuzi, S., Saito, H., Kamo, N., Naito, A.
- Journal Title
  
  Photochemistry and Photobiology 83(2)
  
  Pages: 339-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770136
[Patent] METHOD FOR PRODUCING MEMBRANE PROTEIN2009
- Inventor(s)
  Shigeyuki Yokoyama, Kazumi Shimono, Mikako Shirouzu, Mie Goto
- Industrial Property Rights Holder
  RIKEN
- Filing Date
  2009-05-14
- Data Source
  KAKENHI-PROJECT-19770136
[Patent] 2型ヒスタミン受容体タンパク質に結合し,かつ2型ヒスタミン受容体とヒスタミンとの結合を阻止し得るモノクローナル抗体2008
- Inventor(s)
  渡邊武,横山茂之,白水美香子,寺田貴帆,下野和実
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2008-07-24
- Data Source
  KAKENHI-PROJECT-19770136
[Patent] 膜タンパク質の製造方法2007
- Inventor(s)
  下野和実, 他3名
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Number
  2007-286899
- Filing Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] 分子動力学法による多剤排出トランスポーターEmrEの基質結合における水分子の動的解析2020
- Author(s)
  下野和実，宮本秀一
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07549
[Presentation] 大腸菌多剤排出トランスポーターEmrEにおける基質結合駆動エネルギーのpH依存的転換メカニズム2019
- Author(s)
  下野和実，染谷友美，白水美香子，横山茂之，宮本秀一，宮内正二
- Organizer
  第14回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-19K07549
[Presentation] 大腸菌多剤排出トランスポーターEmrE の基質結合における水分子の役割2019
- Author(s)
  下野和実，宮本秀一，宮内正二
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07549
[Presentation] 白金錯体抗がん薬を輸送するヒト銅トランスポーター(hCTR1)の無細胞膜タンパク質合成系を利用した大量合成2014
- Author(s)
  下野和実,水谷賢人,池本友寛,小丸明日香,染谷友美,白水美香子,横山茂之,宮内正二
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 等温滴定型熱量計による大腸菌由来多剤輸送担体EmrEの基質結合様式の解析2013
- Author(s)
  下野和実,森喜郎,奈良敏文,染谷友美,白水美香子,横山茂之,宮内正二
- Organizer
  第2回日本生物物理関東支部研究会
- Place of Presentation
  小金井,東京
- Year and Date
  2013-03-05
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] アポトーシスを誘導する核酸誘導体の濃縮型核酸輸送担体による輸送2013
- Author(s)
  下野和実,福田恭大,丸山晴美,田母神淳,紙谷浩之,奈良敏文,宮内正二
- Organizer
  第8回トランスポーター研究会年会
- Place of Presentation
  熊本
- Year and Date
  2013-06-15
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 等温滴定型熱量計による多剤輸送担体EmrEの基質結合様式の解析2013
- Author(s)
  下野和実,森喜郎,奈良敏文,染谷友美,白水美香子,横山茂之,宮内正二
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都
- Year and Date
  2013-10-29
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 無細胞膜タンパク質合成系を利用したヒト銅トランスポーター(hCtr1)の大量合成2012
- Author(s)
  下野和実,水谷賢人,横山茂之,宮内正二
- Organizer
  第7回トランスポーター研究会年会
- Place of Presentation
  京都
- Year and Date
  2012-06-09
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 無細胞タンパク質合成技術を利用した膜タンパク質の構造・機能解析2012
- Author(s)
  下野和実
- Organizer
  よこはまNMR構造生物学研究会第44回ワークショップ(招待講演)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 無細胞タンパク質合成技術を利用した膜タンパク質の構造・機能解析2012
- Author(s)
  下野和実
- Organizer
  よこはまNMR構造生物学研究会第44回ワークショップ
- Place of Presentation
  横浜
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 膜タンパク質の構造・機能研究を加速する無細胞タンパク質合成技術2011
- Author(s)
  下野和実
- Organizer
  東邦大学薬学部特別講演
- Place of Presentation
  船橋,千葉
- Year and Date
  2011-12-21
- Invited
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 膜タンパク質の構造・機能研究を加速する無細胞タンパク質合成技術2011
- Author(s)
  下野和実
- Organizer
  東邦大学薬学部特別講演(招待講演)
- Place of Presentation
  船橋，千葉
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 調製困難なロドプシン類の機能的大量合成法2011
- Author(s)
  下野和実
- Organizer
  特定領域研究「高次系分子科学」第１２回公開ミニシンポジウム「光受容タンパク質」(招待講演)
- Place of Presentation
  蒲郡，愛知
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 等温滴定型熱量計による大腸菌由来プロトン/オリゴペプチド共輸送担体と基質との相互作用解析2011
- Author(s)
  下野和実,浅倉祐未,宮内正二
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 調製困難なロドプシン類の機能的大量合成法2011
- Author(s)
  下野和実
- Organizer
  特定領域研究「高次系分子科学」第12回公開ミニシンポジウム「光受容タンパク質」
- Place of Presentation
  蒲郡,愛知
- Year and Date
  2011-10-26
- Invited
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] Na+/モノカルボン酸共輸送担体 (SMCT) を介して体内に蓄積する毒性化合物に対する解毒剤の検討2011
- Author(s)
  下野和実，上野裕美，駄場崎泰洋，加茂直樹，宮内正二
- Organizer
  第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 等温滴定型熱量計を用いた大腸菌由来H^+/オリゴペプチド共輸送担体(YdgR)の基質結合の熱力学的解析2011
- Author(s)
  下野和実,浅倉祐未,宮内正二
- Organizer
  第6回トランスポーター研究会
- Place of Presentation
  仙台
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] Na^+/モノカルボン酸共輸送担体(SMCT)を介して体内に蓄積する毒性化合物に対する解毒剤の検討2011
- Author(s)
  下野和実,上野裕美,駄場崎泰洋,加茂直樹,宮内正二
- Organizer
  第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高松
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 等温滴定型熱量計を用いた大腸菌由来 H+/オリゴペプチド共輸送担体（YdgR）の基質結合の熱力学的解析2011
- Author(s)
  下野和実，浅倉祐未，宮内正二
- Organizer
  第6回トランスポーター研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] Thermodynamic characterization of interaction between small multidrug resistance transporter (EmrE) and its substrate at various pHs2010
- Author(s)
  Kazumi Shimono
- Organizer
  Pharmaceutical Sciences World Congress 2010
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] 等温滴定型熱量計による多剤トランスポーターEmrEと基質との相互作用解析2010
- Author(s)
  下野和実
- Organizer
  第4回トランスポーター研究会九州部会
- Place of Presentation
  長崎
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] Thermodynamic characterization of interacrion between small multidrug resistance transporter (EmrE) and its substrate at various pHs2010
- Author(s)
  Shimono, K., Someya, T., Shirouzu, M., Yokoyama, S., Miyauchi, S.
- Organizer
  Pharmaceutical Sciences World Congress 2010
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] Thermodynamic study of pH dependence on interaction between small multidrug resistance transporter (EmrE) and its substrate2010
- Author(s)
  Shimono, K., Someya, T., Shirouzu, M., Yokoyama, S., Miyauchi, S.
- Organizer
  第48回日本生物物理学会年会
- Place of Presentation
  仙台
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] 多剤輸送担体EmrEと基質とのpH依存的相互作用変化の熱力学的特性2010
- Author(s)
  下野和実, 染谷友美, 白水美香子, 横山茂之, 宮内正二
- Organizer
  日本生物物理中国四国支部例会
- Place of Presentation
  松山
- Year and Date
  2010-05-08
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] 多剤輸送担体EmrEと基質とのpH依存的相互作用変化の熱力学的特性2010
- Author(s)
  下野和実
- Organizer
  日本生物物理中国四国支部例
- Place of Presentation
  松山
- Year and Date
  2010-05-08
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] Thermodynamic study of pH dependence on interaction between small multidrug resistance transporter (EmrE) and its substrate2010
- Author(s)
  Kazumi Shimono
- Organizer
  日本生物物理学会第48回年会
- Place of Presentation
  仙台
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] 等温滴定型熱量計による多剤輸送担体EmrEと基質との相互作用解析2010
- Author(s)
  下野和実
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] SMR型多剤排出タンパク質の無細胞大量機能発現および等温滴定型熱量計による基質との相互作用解析2009
- Author(s)
  下野和実
- Place of Presentation
  札幌
- Year and Date
  2009-08-07
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] SMR型多剤輸送担体と基質の相互作用に伴う熱量変化2009
- Author(s)
  下野和実
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  徳島
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] SMR型多剤排出輸送担体と基質の相互作用に伴う熱量変化2009
- Author(s)
  下野和実, 他4名
- Organizer
  第47回日本生物物理学会年会
- Place of Presentation
  徳島
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] Na^+共役型モノカルボン酸輸送担体(SMCT)に対する柑橘類抽出成分の効果2009
- Author(s)
  下野和実, 他3名
- Organizer
  第4回トランスポーター研究会
- Place of Presentation
  東京
- Year and Date
  2009-05-23
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] Na+共役型モノカルボン酸輸送担体(SMCT)に対する柑橘類抽出成分の効果2009
- Author(s)
  下野和実
- Organizer
  第4回トランスポーター研究会
- Place of Presentation
  東京
- Year and Date
  2009-05-28
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] SMR型多剤排出輸送担体と基質の相互作用に伴う熱量変化2009
- Author(s)
  下野和実
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  徳島
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] Functional Overexpression of Membrane Proteins Using Cell-free Protein Synthesis System Supplemented with Steroid Detergent and Lipid2008
- Author(s)
  Kazumi Shimono
- Organizer
  Protein Island Matsuyama (PIM) International Symposium 2008
- Place of Presentation
  Matsuyama
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] Functional Overexpression of Membrane Proteins Using Cell-free Protein Synthesis System Supplemented with Steroid Detergent and Lipid2008
- Author(s)
  Kazumi Shimono
- Organizer
  Protein Island Matsuyama (PIM) International Symposium 2008
- Place of Presentation
  Matsuyama, Japan
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] Functional Overexpression of Membrane Proteins Using Cell-free Protein Synthesis System Supplemented with Steroid Detergent and Lipid2008
- Author(s)
  Kazumi Shimono, 他4名
- Organizer
  Protein Island Matsuyama (PIM) International Symposium 2008
- Place of Presentation
  松山
- Year and Date
  2008-09-26
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] SMR型多剤排出タンパク質の無細胞大量機能発現および等温滴定型熱量計による基質との相互作用解析2008
- Author(s)
  下野和実
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-08-07
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] SMR型多剤排出タンパク質の無細胞大量機能発現および等温滴定型熱量計による基質との相互作用解析2008
- Author(s)
  下野和実, 他6名
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-08-07
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] 無細胞タンパク質合成系を利用した新規膜タンパク質機能発現系の開発2007
- Author(s)
  下野和実
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-19770136
[Presentation] アポトーシスを誘導する核酸誘導体の濃縮型核酸輸送担体による輸送
- Author(s)
  下野和実，福田恭大，丸山晴美，田母神淳，紙谷浩之，奈良敏文，宮内正二
- Organizer
  第8回トランスポーター研究会年会
- Place of Presentation
  熊本大学薬学部（熊本市）
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 等温滴定型熱量計による多剤輸送担体EmrEの基質結合様式の解析
- Author(s)
  下野和実，森喜郎，奈良敏文，染谷友美，白水美香子，横山茂之，宮内正二
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  国立京都国際会館（京都市）
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 等温滴定型熱量計による大腸菌由来多剤輸送担体EmrEの基質結合様式の解析
- Author(s)
  下野和実，森喜郎，奈良敏文，染谷友美，白水美香子，横山茂之，宮内正二
- Organizer
  第２回日本生物物理関東支部研究会
- Place of Presentation
  東京農工大学小金井キャンパス(東京都)
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 白金錯体抗がん薬を輸送するヒト銅トランスポーター（hCTR1）の無細胞膜タンパク質合成系を利用した大量合成
- Author(s)
  下野和実，水谷賢人，池本友寛，小丸明日香，染谷友美，白水美香子，横山茂之，宮内正二
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館（熊本市）
- Data Source
  KAKENHI-PROJECT-23790060
[Presentation] 無細胞膜タンパク質合成系を利用したヒト銅トランスポーター（hCtr1）の大量合成
- Author(s)
  下野和実，水谷賢人，横山茂之，宮内正二
- Organizer
  第７回トランスポーター研究会年会
- Place of Presentation
  京都大学農学部(京都府)
- Data Source
  KAKENHI-PROJECT-23790060

1. SHINOMIYA Nariyoshi

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# of Collaborated Products: 1 results
2. MATSUO Hirotaka

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# of Collaborated Products: 1 results
3. 宮内正二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 奈良敏文

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# of Collaborated Products: 1 results
5. 加茂直樹

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Shimono Kazumi 下野 和実

SHIMONO Kazumi 下野 和実

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Basic research on thermodynamics-based drug design of multi drug efflux transporter inhibitorsPrincipal Investigator

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Thermodynamics-based mechanism for the regulation of substrate binding affinity of proton coupled drug transportersPrincipal Investigator

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Development of Expression System for Photoreceptor Using Cell-free Protein Synthesis and Application of Its system for Their Functional AnalysisPrincipal Investigator

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[Book] オプトジェネティックスー光工学と遺伝学による行動制御技術の最前線―2013

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[Book] オプトジェネティックスー光工学と遺伝学による行動制御技術の最前線—;第1編第2章第1節"調製困難なロドプシン類の機能的大量合成法"2013

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[Book] Photo-induced proton transfers of microbial rhodopsins. Molecular Photochemistry - Various Aspects2012

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[Book] Molecular Photochemistry - Various Aspects (Book edited by Dr. Satyen Saha) Chapter 5 "Photo-induced proton transfers of microbial rhodopsins."2012

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[Journal Article] Estimation of the Diffusion Coefficients of Small Molecules by Diffusion Measurements with Agar-gel and Theoretical Molecular Modeling2022

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[Journal Article] Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity2021

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[Journal Article] Molecular Modeling to Estimate the Diffusion Coefficients of Drugs and Other Small Molecules2020

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[Journal Article] A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility2014

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[Journal Article] A study of the interaction of drugs with liposomes with isothermal titration calorimetry2013

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[Journal Article] Thermodynamic parameters of anion binding to halorhodopsin from Natronomonas pharaonis by isothermal titration calorimetry2013

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[Journal Article] Photoinduced proton release in proteorhodopsin at low pH: The possibility of a decrease in the pKa of Asp2272012

Shimono Kazumi 下野和実

SHIMONO Kazumi 下野和実