Ohnishi Takayuki 大西隆之

… Alternative Names

OHNISHI Takayuki 大西隆之

大西隆之オオニシタカユキ

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Researcher Number	30418959
Other IDs
Affiliation (Current)	2025: 山口大学, 大学研究推進機構, 講師(特命) 2025: 京都大学, 医学研究科, 特定助教
Affiliation (based on the past Project Information) *help	2025: 山口大学, 大学研究推進機構, 講師(特命) 2023: 山口大学, 大学研究推進機構, 講師(特命) 2019 – 2022: 大阪物療大学, 保健医療学部, 助教 2012 – 2016: 公益財団法人先端医療振興財団, その他部局等, 研究員 2013: 公益財団法人先端医療振興財団, 研究員 … More 2011: 公益財団法人先端医療振興財団, 医薬品開発・支援部門, 研究員 2009: 新潟大, 医歯学系, 助教 2008: Niigata University, 医歯学系, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 55010:General surgery and pediatric surgery-related / 疼痛学 Except Principal Investigator Pathological medical chemistry
Keywords	Principal Investigator 癌幹細胞 / がん幹細胞 / シグナル伝達経路 / 乳がん / 神経科学 / 脳・神経 / シグナル伝達 Except Principal Investigator 神経細胞死 / 構造解析 / 蛋白質 … More / シグナル伝達 / 脳神経疾患 / 新規創薬ターゲット / 立体構造 / ナトリウムポンプ / 神経変性疾患 / シナプス / アミロイド / タウ / ミトコンドリア / カルシウム / 構造異常 / 認知症 Less

加齢関連可変性メチル領域のDNAメチル化を標的としたノックインマウスの解析Principal Investigator
- Principal Investigator
  
  大西隆之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Yamaguchi University
Functional analysis of KIF20B involved in microtubule dynamics and its application to novel treatment of breast cancer stem cells.Principal Investigator
- Principal Investigator
  
  Ohnishi Takayuki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Yamaguchi University
  Osaka Butsuryo University
Elucidation of a neurodegenerative mechanism induced by a new Alzheimer's disease drug target and its inhibition
- Principal Investigator
  
  Hoshi Minako
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Foundation for Biomedical Research and Innovation
A study on the molecular mechanisms of neurodegeneration induced by high-mass amyloid-beta assembly, amylospheroids (ASPD)
- Principal Investigator
  
  HOSHI Minako
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Foundation for Biomedical Research and Innovation
神経因性疼痛におけるPACAPの分子機構の解明Principal Investigator
- Principal Investigator
  
  大西隆之
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  疼痛学
- Research Institution
  Niigata University

All 2019 2015 2014 2011 2009 2008 Other

All Journal Article Presentation

[Journal Article] Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion2019
- Author(s)
  Komura Hitomi、Kakio Shota、Sasahara Tomoya、Arai Yoshie、Takino Naomi、Sato Michio、Satomura Kaori、Ohnishi Takayuki、Nabeshima Yo-ichi、Muramatsu Shin-ichi、Kii Isao、Hoshi Minako
- Journal Title
  
  iScience
  
  Volume: 13 Pages: 452-477
- DOI
  10.1016/j.isci.2019.01.018
- NAID
  120006576457
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17779, KAKENHI-PLANNED-26115004, KAKENHI-PROJECT-19K09044
[Journal Article] Na,K-ATPase 3 is a death target of Alzheimer patient amyloid-assembly2015
- Author(s)
  Ohnishi, T., et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: 112
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293075
[Journal Article] Two distinct amyloid β-protein (Aβ) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology and toxicity analyses2011
- Author(s)
  Matsumura, S., Shinoda, K., Yamada, M., Yokojima, S., Inoue, M., Ohnishi, T., Shimada, T., Kikuchi, K., Masui, D., Hashimoto, S., Sato, M., Ito, A., Akioka, M., Takagi, S., Nakamura, Y., Nemoto, K., Hasegawa, Y., Takamoto, H., Inoue, H., Nakamura, S., Nabeshima, Y., Teplow, D.B., Kinjo, M., and Hoshi, M.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 11555-11562
- Data Source
  KAKENHI-PROJECT-23390079
[Journal Article] 慢性疼痛の発生・維持機構2008
- Author(s)
  伊藤誠二, 大西隆之
- Journal Title
  
  慢性疼痛の理解と医療連携
  
  Pages: 56-57
- Data Source
  KAKENHI-PROJECT-20602014
[Journal Article] Characterization of signaling pathway for the translocation of neuronal nitric oxide synthase to the plasma membrane by PACAP.2008
- Author(s)
  T. Ohnishi., et al.
- Journal Title
  
  J. Neurochem. 105
  
  Pages: 2271-2285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20602014
[Presentation] Calcium-mediated neurotoxicity of high-mass amyloid-beta assembly, amylospheroids (ASPD) to mature hippocampal neurons through activation of voltage-gated calcium channels2014
- Author(s)
  Ohnishi T, Sasahara T, Komura H, Arai Y, Nishiyama T, Hoshi M
- Organizer
  Society for Neuroscience 2014
- Place of Presentation
  Washington, D.C.
- Year and Date
  2014-11-15
- Data Source
  KAKENHI-PROJECT-26293075
[Presentation] Mechanism of mature neuron-specific toxicity induced by high-mass a myloid β-protein assembly with a unique toxic structure2011
- Author(s)
  Hoshi, M., Ohnishi, T., Inoue, M., Hiroaki, H., Nabeshima, Y., Kakita, A.
- Organizer
  The 10^<th> international conference on Alzheimer's diseases
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] A new toxic target for a high-mass amyloid β-protein assembly with a unique toxic structure2011
- Author(s)
  Hoshi, M., Ohnishi, T., Inoue, M., Hiroaki, H., Nabeshima, Y., Kakita, A
- Organizer
  "International conference on Alzheimer's disease : Return to the Basics" at Annual meeting for Japanese Biochemical Societies, organized by Professors Iwata and Hoshi
- Place of Presentation
  Kyoto
- Year and Date
  2011-09-21
- Invited
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] A new toxic target for a high-mass amyloid ss-protein assembly with a unique toxic structure "International conference on Alzheimer's disease : Return to the Basics" at Annual meeting for Japanese Biochemical Societies, organized by Professors Iwata and Hoshi2011
- Author(s)
  Hoshi, M., Ohnishi, T., Inoue, M., Hiroaki, H., Nabeshima, Y., Kakita, A.
- Organizer
  Annual meeting for Japanese Biochemical Societies
- Place of Presentation
  Kyoto(オーガナイザー)(招待講演)
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] ATPによるnNOSの細胞膜への移動の分子機構の解明2009
- Author(s)
  大西隆之, 芦高恵美子, 松村伸治, 樋口宗史, 伊藤誠二
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-20602014
[Presentation] PACAPシグナル伝達を介した一酸化窒素合成酵素(nNOS)の機能調節の分子機構2008
- Author(s)
  大西隆之, 芦高恵美子, 松村伸治, 樋口宗史, 伊藤誠二
- Organizer
  第59回日本薬理学会北部会
- Place of Presentation
  仙台
- Year and Date
  2008-09-29
- Data Source
  KAKENHI-PROJECT-20602014
[Presentation] ATPによるnNOSの細胞膜への移動の分子機構の解明2008
- Author(s)
  大西隆之, 芦高恵美子, 松村伸治, 樋口宗史, 伊藤誠二
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20602014
[Presentation] アミロイドβペプチドの毒性会合体形成経路の解明
- Author(s)
  井上雅文、大西隆之、廣明秀一、菊地和也、鍋島陽一、萩原正敏、金城政孝、星美奈子
- Organizer
  第7回日本ケミカルバイオロジー学会年会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] Mechanism of mature neuron-specific toxicity induced by amylospheroids (ASPDs): analyses of the down-stream signal transduction pathways leading to the severe neurodegeneration.
- Author(s)
  T. Ohnishi T, M. Inoue, H. Komura, M. Tada, Y. Nabeshima, M. Hagiwara, A. Kakita and M. Hoshi M.
- Organizer
  Society for Neuroscience 2012
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-23390079

1. HOSHI Minako (30374010)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. INOUE Masafumi (10586655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. KAKITA Akiyoshi (80281012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 松村伸治 (70276393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 廣明秀一 (10336589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 水上洋一 (80274158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 小村仁美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohnishi Takayuki 大西 隆之

OHNISHI Takayuki 大西 隆之

大西 隆之 オオニシ タカユキ

Research Projects

Research Products

Co-Researchers

加齢関連可変性メチル領域のDNAメチル化を標的としたノックインマウスの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of KIF20B involved in microtubule dynamics and its application to novel treatment of breast cancer stem cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a neurodegenerative mechanism induced by a new Alzheimer's disease drug target and its inhibition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the molecular mechanisms of neurodegeneration induced by high-mass amyloid-beta assembly, amylospheroids (ASPD)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経因性疼痛におけるPACAPの分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Na,K-ATPase &#61537;3 is a death target of Alzheimer patient amyloid-&#61538;&#61472;assembly2015

Author(s)

Journal Title

Data Source

[Journal Article] Two distinct amyloid β-protein (Aβ) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology and toxicity analyses2011

Author(s)

Journal Title

Data Source

[Journal Article] 慢性疼痛の発生・維持機構2008

Author(s)

Journal Title

Data Source

[Journal Article] Characterization of signaling pathway for the translocation of neuronal nitric oxide synthase to the plasma membrane by PACAP.2008

Author(s)

Journal Title

Data Source

[Presentation] Calcium-mediated neurotoxicity of high-mass amyloid-beta assembly, amylospheroids (ASPD) to mature hippocampal neurons through activation of voltage-gated calcium channels2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Mechanism of mature neuron-specific toxicity induced by high-mass a myloid β-protein assembly with a unique toxic structure2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] A new toxic target for a high-mass amyloid β-protein assembly with a unique toxic structure2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] A new toxic target for a high-mass amyloid ss-protein assembly with a unique toxic structure "International conference on Alzheimer's disease : Return to the Basics" at Annual meeting for Japanese Biochemical Societies, organized by Professors Iwata and Hoshi2011

Author(s)

Organizer

Place of Presentation

Year and Date

Ohnishi Takayuki 大西隆之

OHNISHI Takayuki 大西隆之

大西隆之オオニシタカユキ

[Journal Article] Na,K-ATPase 3 is a death target of Alzheimer patient amyloid-assembly2015