Obara Keisuke 小原圭介

… Alternative Names

OBARA Keisuke 小原圭介

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Researcher Number	30419858
Other IDs
External Links
Affiliation (Current)	2025: 名古屋大学, 理学研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 名古屋大学, 理学研究科, 講師 2017 – 2021: 名古屋大学, 理学研究科, 助教 2016: 北海道大学, 薬学研究院, 助教 2011 – 2015: 北海道大学, 薬学研究科(研究院), 助教 2014: 北海道大学, 大学院薬学研究院, 助教 2012 – 2013: 北海道大学, 大学院・薬学研究院, 助教 2009 – 2010: Hokkaido University, 大学院・薬学研究院, 助教
Review Section/Research Field	Principal Investigator Functional biochemistry / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Cell biology / Functional biochemistry / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator 脂質 / センサー / 脂質非対称 / 細胞膜 / 酵母 / Rim101 / 出芽酵母 / 真菌感染症 / 生体膜 / タンパク質分解 … More / タンパク質 / ユビキチン / ユビキチン化 / シグナル伝達 / Rim21 / シグナル / yeast / lipid asymmetry / lipid / Plasma membrane / センシング / ストレス応答 / バイオセンサー / アルカリ / 情報伝達 / 非対称 / Rim / 細胞情報伝達機構 / 液胞 / 脂肪酸 / オートファゴソーム / スフィンゴ脂質 / スフィンゴ / オートファジー … More Except Principal Investigator 生体膜 / 脂質 / 脂質非対称 / スフィンゴ脂質 / 細胞膜 / シグナル伝達 / 極長鎖脂肪酸 / 脂肪酸 / 代謝 / 膜動態 / GFP / 出芽酵母 / ストレス / 生体膜、 / バイオセンサー / フロッパーゼ / ユビキチン化 / アルカリ / リン脂質 / 脂質二重層 / Rim101経路 / グリセロリン脂質 / センサー / リポソーム / エンドソーム / 皮膚バリア機能 / 小胞輪送 / 皮膚 / 小胞輸送 / ノックアウトマウス / 代謝異常 / 皮膚バリア / 3-ヒドロキシアシルCoA脱水酵素 / アシルCoA / 縮合酵素 / 脂質輸送 / ホスファチジルイノシトール / タンパク質 / 遺伝子 / 細胞内輸送 Less

細胞膜との相互作用を介した脂質非対称センシングの分子機構Principal Investigator
- Principal Investigator
  
  小原圭介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Nagoya University
Sensing mechanism and signal output of plasma membrane lipid asymmetryPrincipal Investigator
- Principal Investigator
  
  Obara Keisuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Nagoya University
Development of a lipid asymmetry biosensor that dramatically facilitates studies on biomembranes
- Principal Investigator
  
  Kamura Takumi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Nagoya University
Elucidation of sensing mechanism of lipid asymmetry and establishment of bases for its applicationPrincipal Investigator
- Principal Investigator
  
  Obara Keisuke
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagoya University
  Hokkaido University
Sensing and mending mechanism of altered lipid asymmetryPrincipal Investigator
- Principal Investigator
  
  OBARA Keisuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Elucidation of the molecular mechanism sensing lipid asymmetry and transducing the signals
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Hokkaido University
Elucidation of the synthetic mechanism, disorders, and physiological functions of very long-chain fatty acids
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Identification of the sensor molecule that senses lipid asymmetry and elucidation of the molecular mechanism of its intracellular signaling
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Hokkaido University
Sensing mechanism of lipid asymmetry and cellular responsePrincipal Investigator
- Principal Investigator
  
  OBARA Keisuke
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Analysis of the molecular mechanism of autophagosome formation from the viewpoint of lipid moleculesPrincipal Investigator
- Principal Investigator
  
  OBARA Keisuke
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Elucidation of the mechanism of intracellular phosphatidylinositol trafficking by the Phs1 family
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] 細胞膜脂質非対称の感知と細胞応答2021
- Author(s)
  小原　圭介
- Journal Title
  
  アグリバイオ
  
  Volume: 5 Pages: 43-46
- NAID
  40022494408
- Data Source
  KAKENHI-PROJECT-19K06561
[Journal Article] The Rim101 pathway mediates adaptation to external alkalization and altered lipid asymmetry: hypothesis describing the detection of distinct stresses by the Rim21 sensor protein2020
- Author(s)
  Obara K, Kamura T
- Journal Title
  
  Current Genetics
  
  Volume: 67 Issue: 2 Pages: 213-217
- DOI
  10.1007/s00294-020-01129-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06561, KAKENHI-PUBLICLY-19H04957
[Journal Article] <i>N</i>-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane2020
- Author(s)
  Obara K, Kotani T, Nakatogawa H, Kihara A, Kamura T
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 45 Issue: 1 Pages: 1-8
- DOI
  10.1247/csf.19021
- NAID
  130007784461
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06561, KAKENHI-PROJECT-19K16071, KAKENHI-PUBLICLY-19H04957, KAKENHI-PLANNED-19H05708, KAKENHI-PROJECT-17H01430, KAKENHI-PROJECT-16K07288, KAKENHI-PROJECT-18K19292
[Journal Article] Rapid turnover of transcription factor Rim101 highlights a flexible adaptation mechanism against environmental stress in Saccharomyces cerevisiae.2020
- Author(s)
  Obara K, Higuchi M, Ogura Y, Nishimura K, Kamura T
- Journal Title
  
  Genes to Cells
  
  Volume: 25 Issue: 10 Pages: 651-662
- DOI
  10.1111/gtc.12801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06561, KAKENHI-PUBLICLY-19H04957, KAKENHI-PROJECT-20H03208
[Journal Article] The Rim101 pathway contributes to ER stress adaptation through sensing the state of plasma membrane.2017
- Author(s)
  Obara K, Kihara A
- Journal Title
  
  Biochemical Journal
  
  Volume: VOL 474 Issue: 1 Pages: 51-63
- DOI
  10.1042/bcj20160580
- NAID
  120006374981
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K07288
[Journal Article] Loop 5 region is important for the activity of the long-chain base transporter Rsb1.2017
- Author(s)
  Makuta H, Obara K, Kihara A
- Journal Title
  
  Journal of Biochemistry
  
  Volume: VOL 161 Pages: 207-213
- DOI
  10.1093/jb/mvw059
- NAID
  120006401452
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K07288
[Journal Article] The C-terminal cytosolic region of Rim21 senses alterations in plasma membrane lipid composition: Insights into sensing mechanisms for plasma membrane lipid asymmetry2015
- Author(s)
  Nishino K, Obara K, and Kihara A
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 52 Pages: 30797-30805
- DOI
  10.1074/jbc.m115.674382
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440038
[Journal Article] Opt2 mediates the exposure of phospholipids during cellular adaptation to altered lipid asymmetry.2015
- Author(s)
  Yamauchi S, Obara K, Uchibori K, Kamimura A, Azumi K, and Kihara A
- Journal Title
  
  J Cell Sci
  
  Volume: 128 Pages: 61-69
- DOI
  10.1242/jcs.153890
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440038, KAKENHI-PROJECT-25650059
[Journal Article] Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries2014
- Author(s)
  Cheng J, Fujita A, Yamamoto H, Tatematsu T, Kakuta S, Obara K, Ohsumi Y, Fujimoto T.
- Journal Title
  
  Nat. Commun.
  
  Volume: 5 Issue: 1 Pages: 3207-3207
- DOI
  10.1038/ncomms4207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23000015, KAKENHI-PROJECT-23590234, KAKENHI-PROJECT-24390045, KAKENHI-PROJECT-24770182, KAKENHI-PROJECT-25440038, KAKENHI-PROJECT-25860149
[Journal Article] Signaling events of the Rim101 pathway occur at the plasma membrane in a ubiquitination-dependent manner.2014
- Author(s)
  Obara K and Kihara A
- Journal Title
  
  Mol Cell Biol
  
  Volume: 34 Issue: 18 Pages: 3525-3534
- DOI
  10.1128/mcb.00408-14
- NAID
  120005525215
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440038, KAKENHI-PROJECT-25650059
[Journal Article] Effects on vesicular transport pathways at the late endosome in cells with limited very long-chain fatty acids2013
- Author(s)
  Obara K, Kojima R, Kihara A
- Journal Title
  
  J. Lipid Res.
  
  Volume: 54 Issue: 3 Pages: 831-842
- DOI
  10.1194/jlr.m034678
- NAID
  120005228358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Unperverted synthesis of complex sphingolipids is essential for cell survival under nitrogen starvation2013
- Author(s)
  Yamagata M, Obara K, Kihara A
- Journal Title
  
  Genes Cells
  
  Volume: 18 Issue: 8 Pages: 650-659
- DOI
  10.1111/gtc.12062
- NAID
  120005367401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-25440038
[Journal Article] Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation2013
- Author(s)
  Mizutani Y, Sun H, Ohno Y, Sassa T, Wakashima T, Obara M, Yuyama K, Kihara A, Igarashi Y
- Journal Title
  
  PLos One
  
  Volume: 8 Issue: 6 Pages: e67317-e67317
- DOI
  10.1371/journal.pone.0067317
- NAID
  120005322424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] オートファジーに関わるタンパク質とその役割2013
- Author(s)
  小林孝文、小原圭介、大隅良典
- Journal Title
  
  ファルマシア
  
  Volume: 49 Pages: 508-512
- Data Source
  KAKENHI-PROJECT-25440038
[Journal Article] Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH in Saccharomyces cerevisiae2012
- Author(s)
  Obara, K.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Issue: 46 Pages: 38473-38481
- DOI
  10.1074/jbc.m112.394205
- NAID
  120005090608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657120, KAKENHI-PROJECT-23770135, KAKENHI-PROJECT-24770182
[Journal Article] Involvement of sphingolipids in autophagy in Saccharomyces cerevisiae2011
- Author(s)
  Yamagata M, Obara K, Kihara A
- Journal Title
  
  Chem. Phys. Lipids
  
  Volume: 164 Pages: S34-S35
- DOI
  10.1016/j.chemphyslip.2011.05.110
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] PtdIns 3-kinase orchestrates autophagosome formation in yeast.2011
- Author(s)
  Obara K, Ohsumi Y
- Journal Title
  
  Journal of Lipids
  
  Pages: 1-9
- NAID
  120002989254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770129
[Journal Article] Atg14, a key player in orchestrating autophagy2011
- Author(s)
  Obara K, Ohsumi Y
- Journal Title
  
  Int.J.Cell Biol.
  
  Volume: 2011 Pages: 1-7
- DOI
  10.1155/2011/713435
- NAID
  120003878522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000015, KAKENHI-PROJECT-23770135
[Journal Article] PtdIns 3-kinase orchestrates autophagosome formation in yeast.2011
- Author(s)
  Obara K and Ohsumi Y
- Journal Title
  
  J Lipids
  
  Volume: 2011 Pages: 1-9
- DOI
  10.1155/2011/498768
- NAID
  120002989254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770135
[Journal Article] Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae2011
- Author(s)
  Yamagata M, Obara K, Kihara A
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 410 Issue: 4 Pages: 786-791
- DOI
  10.1016/j.bbrc.2011.06.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-23770135
[Presentation] 細胞膜脂質非対称と細胞外物理化学変数の関係2022
- Author(s)
  小原圭介、安田有那、嘉村巧
- Organizer
  酵母遺伝学フォーラム第55回研究報告会
- Data Source
  KAKENHI-PROJECT-19K06561
[Presentation] 細胞膜脂質非対称と細胞外物理化学変数の関係2022
- Author(s)
  小原圭介、安田有那、嘉村巧
- Organizer
  酵母遺伝学フォーラム第55回研究報告会
- Data Source
  KAKENHI-PROJECT-22K06141
[Presentation] 細胞膜脂質非対称センシング機構の解明とその応用2021
- Author(s)
  小原圭介
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06561
[Presentation] 転写因子Rim101の迅速な分解からみたストレス応答経路同士の相互作用2020
- Author(s)
  小原　圭介、樋口　舞、嘉村　巧
- Organizer
  酵母遺伝学フォーラム第53回研究報告会
- Data Source
  KAKENHI-PROJECT-19K06561
[Presentation] 脂質非対称性の感知機構から見えてきた細胞膜の新たな役割2020
- Author(s)
  小原　圭介
- Organizer
  第72回日本生物工学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06561
[Presentation] 脂質非対称性の感知機構から見えてきた細胞膜の新たな役割2020
- Author(s)
  小原圭介
- Organizer
  第72回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] 脂質非対称性の感知機構から見えてきた細胞膜の新たな役割2020
- Author(s)
  小原圭介
- Organizer
  第72回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-19K06561
[Presentation] 細胞外刺激と細胞膜脂質非対称の関係性の解析2019
- Author(s)
  安田有那、小原圭介、嘉村巧
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] Development of a biosensor for the plasma membrane lipid asymmetry.2019
- Author(s)
  Obara K, Yasuda A and Kamura T
- Organizer
  29th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] Development of a biosensor for the plasma membrane lipid asymmetry.2019
- Author(s)
  Obara K, Yasuda A and Kamura T
- Organizer
  29th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06561
[Presentation] 細胞外刺激と細胞膜脂質非対称の関係性の解析2019
- Author(s)
  安田有那、小原圭介、嘉村巧
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06561
[Presentation] ユビキチン化を介した細胞膜脂質非対称シグナリング2019
- Author(s)
  小原圭介、嘉村巧
- Organizer
  第2回ユビキチン研究会
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] 細胞膜脂質非対称バイオセンサーの開発2019
- Author(s)
  小原圭介、安田有那、嘉村巧
- Organizer
  第19回日本蛋白質学会年会・第71回日本細胞生物学会大会　合同年次大会
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] 細胞膜脂質非対称バイオセンサーの開発2019
- Author(s)
  小原圭介、安田有那、嘉村巧
- Organizer
  第19回日本蛋白質学会年会・第71回日本細胞生物学会大会　合同年次大会
- Data Source
  KAKENHI-PROJECT-18K19292
[Presentation] Development of a biosensor for the plasma membrane lipid asymmetry.2019
- Author(s)
  Obara K, Yasuda A and Kamura T
- Organizer
  29th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19292
[Presentation] 細胞膜脂質非対称バイオセンサーの開発2019
- Author(s)
  小原圭介、安田　有那、嘉村巧
- Organizer
  第71回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] 細胞膜脂質非対称バイオセンサーの開発2019
- Author(s)
  小原圭介、安田有那、嘉村巧
- Organizer
  第71回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-18K19292
[Presentation] 細胞外刺激と細胞膜脂質非対称の関係性の解析2019
- Author(s)
  安田有那、小原圭介、嘉村巧
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19292
[Presentation] 細胞膜脂質非対称バイオセンサー開発の試み2018
- Author(s)
  安田有那、小原圭介、嘉村巧
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19292
[Presentation] 細胞膜脂質非対称バイオセンサー開発の試み2018
- Author(s)
  安田有那、小原圭介、嘉村巧
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] 細胞膜脂質非対称センサーが細胞内外のストレスを感知する仕組み2017
- Author(s)
  小原　圭介
- Organizer
  日本遺伝学会第89回大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] 細胞膜脂質非対称の感知機構と細胞応答の解明2017
- Author(s)
  小原　圭介
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] 細胞膜脂質非対称センシング機構と細胞応答2016
- Author(s)
  小原　圭介、西野　佳菜子、内堀　健矢、山内　佐織、木原　章雄
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] Sensing mechanism of alterations in plasma membrane lipid asymmetry and external alkalization.2016
- Author(s)
  Obara K, Nishino K, Kihara A
- Organizer
  14th International Congress on Yeasts (ICY14)
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県淡路市）
- Year and Date
  2016-09-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07288
[Presentation] Mechanism for sensing lipid asymmetry of the plasma membrane and external alkalization.2015
- Author(s)
  Obara K, Nishino K, and Kihara A
- Organizer
  27th International Conference on Yeast Genetics and Molecular Biology (ICYGMB)
- Place of Presentation
  Levico Terme (Italy)
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440038
[Presentation] 脂質非対称センサーRim21はERストレスを感知して適応反応に寄与する2015
- Author(s)
  小原圭介、木原章雄
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440038
[Presentation] ユビキチンとESCRT複合体による細胞膜脂質非対称および外界アルカリ化シグナルの伝達2015
- Author(s)
  小原圭介、西野佳菜子、木原章雄
- Organizer
  第67回日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-25440038
[Presentation] Rim21は細胞質領域の荷電アミノ酸残基を用いて細胞膜の脂質非対称を感知する2015
- Author(s)
  西野佳菜子、小原圭介、木原章雄
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440038
[Presentation] リン脂質のフロップに関与する新規酵母因子Opt2の単離・解析2013
- Author(s)
  山内佐織, 小原圭介, 木原章雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-25650059
[Presentation] 細胞膜脂質非対称センサーの同定2013
- Author(s)
  小原圭介, 山本林, 木原章雄
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  ウインク愛知（愛知県）
- Data Source
  KAKENHI-PROJECT-25650059
[Presentation] ユビキチン化が脂質非対称および外界アルカリ化シグナルを細胞膜上で媒介する2013
- Author(s)
  小原圭介, 木原章雄
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Data Source
  KAKENHI-PROJECT-25650059
[Presentation] Rim21 はRim101 経路のセンサータンパク質として中心的な役割を果たす2012
- Author(s)
  小原圭介
- Organizer
  第35 回日本分子生物学会年会
- Place of Presentation
  マリンメッセ福岡（福岡県）
- Data Source
  KAKENHI-PROJECT-23770135
[Presentation] Rim21はRim101経路のセンサータンパク質として中心的な役割を果たす2012
- Author(s)
  小原圭介、山本林、木原章雄
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-23770135
[Presentation] 小胞輸送における極長鎖脂肪酸の機能解析2012
- Author(s)
  小原圭介
- Organizer
  酵母遺伝学フォーラム第45回研究報告会
- Place of Presentation
  京都大学（宇治市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 乱れた脂質非対称への応答に関与する新規因子の単離・解析2012
- Author(s)
  山内佐織,小原圭介,木原章雄
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-23770135
[Presentation] Rim21はRim101経路のセンサータンパク質として中心的な役割を果たす2012
- Author(s)
  小原圭介
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場/マリンメッセ福岡(福岡県)
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23657120
[Presentation] Rim21はRim101経路のセンサータンパク質として中心的な役割を果たす2012
- Author(s)
  小原圭介
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場／マリンメッセ福岡（福岡県）
- Data Source
  KAKENHI-PROJECT-23657120
[Presentation] 脂質非対称の乱れに対する細胞応答の網羅的解析2011
- Author(s)
  小原圭介、山内佐織、神村章子、安住薫、木原章雄
- Organizer
  第34回日本分子生物学会年会(招待講演)
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-23770135
[Presentation] 脂質非対称の乱れに対する細胞応答の網羅的解析2011
- Author(s)
  小原圭介、山内佐織、神村章子、安住薫、木原章雄
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-23770135
[Presentation] 脂質非対称の乱れに対する細胞応答の網羅的解析2011
- Author(s)
  小原圭介
- Organizer
  第34回日本分子生物学会年会,横浜
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23657120
[Presentation] 脂質非対称の乱れに対する細胞応答の網羅的解析2011
- Author(s)
  小原圭介
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23657120
[Presentation] 窒素飢餓応答におけるスフィンゴ脂質の役割2010
- Author(s)
  山形麻旗、小原圭介、木原章雄
- Organizer
  日本薬学会北海道支部第134回例会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21770129
[Presentation] 酵母を用いたオートファジー誘導におけるスフィンゴ脂質の機能解析2009
- Author(s)
  山形麻旗、小原圭介、木原章雄
- Organizer
  第51回日本脂質生化学会
- Place of Presentation
  ウィル愛知(名古屋)
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-21770129
[Presentation] 酵母を用いたオートファジー誘導におけるスフィンゴ脂質の機能解析2009
- Author(s)
  山形麻旗、小原圭介、木原章雄
- Organizer
  第51回日本脂質生化学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21770129
[Presentation] 細胞膜脂質非対称センサーの同定
- Author(s)
  小原圭介、山本林、木原章雄
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  ウインク愛知（愛知）
- Data Source
  KAKENHI-PROJECT-25440038
[Presentation] リン脂質のフロップに関わる新規因子Opt2の発見
- Author(s)
  小原圭介, 山内佐織, 木原章雄
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂／東大寺総合文化センター（奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25650059
[Presentation] Rim21 senses alteration in plasma membrane lipid asymmetry and elicits the signal at the plasma membrane in a ubiquitination-dependent manner
- Author(s)
  Obara K, Nishino K and Kihara A
- Organizer
  The FEBS EMBO 2014 conference
- Place of Presentation
  Paris
- Year and Date
  2014-08-30 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25440038
[Presentation] ユビキチン化が脂質非対称および外界アルカリ化シグナルを細胞膜上で媒介する
- Author(s)
  小原圭介､　木原章雄
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際展示場（兵庫）
- Data Source
  KAKENHI-PROJECT-25440038
[Presentation] Rim21 senses alteration in plasma membrane lipid asymmetry and elicits the signal at the plasma membrane in a ubiquitination-dependent manner
- Author(s)
  Obara K, Nishino K, Kihara A
- Organizer
  FEBS-EMBO
- Place of Presentation
  パリ（フランス）
- Year and Date
  2014-08-30 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25650059
[Presentation] リン脂質のフロップに関わる新規因子Opt2の発見
- Author(s)
  小原圭介、山内佐織、木原章雄
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25440038
[Presentation] リン脂質のフロップに関与する新規酵母因子Opt2の単離・解析
- Author(s)
  山内佐織、小原圭介、木原章雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-25440038

1. KIHARA Akio (50333620)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. SASSA Takayuki (20342793)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. OHNO Yusuke (50611498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Kamura Takumi (40333455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 大隅良典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Obara Keisuke 小原 圭介

OBARA Keisuke 小原 圭介

Research Projects

Research Products

Co-Researchers

細胞膜との相互作用を介した脂質非対称センシングの分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Sensing mechanism and signal output of plasma membrane lipid asymmetryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a lipid asymmetry biosensor that dramatically facilitates studies on biomembranes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of sensing mechanism of lipid asymmetry and establishment of bases for its applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sensing and mending mechanism of altered lipid asymmetryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the molecular mechanism sensing lipid asymmetry and transducing the signals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the synthetic mechanism, disorders, and physiological functions of very long-chain fatty acids

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the sensor molecule that senses lipid asymmetry and elucidation of the molecular mechanism of its intracellular signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sensing mechanism of lipid asymmetry and cellular responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the molecular mechanism of autophagosome formation from the viewpoint of lipid moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of intracellular phosphatidylinositol trafficking by the Phs1 family

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 細胞膜脂質非対称の感知と細胞応答2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] The Rim101 pathway mediates adaptation to external alkalization and altered lipid asymmetry: hypothesis describing the detection of distinct stresses by the Rim21 sensor protein2020

Author(s)

Journal Title

DOI

Obara Keisuke 小原圭介

OBARA Keisuke 小原圭介