OHTSUBO Toshio 大坪俊夫

Researcher Number	30423974
Affiliation (based on the past Project Information) *help	2016: 九州大学, 医学研究院, 准教授 2013 – 2015: 九州大学, 大学病院, 講師 2014: 九州大学, 病院, 講師 2011 – 2012: 九州大学, 大学病院, 助教 2007 – 2008: Kyushu University, 大学病院, 助教 2006: 九州大学, 大学病院, 助手
Review Section/Research Field	Principal Investigator Kidney internal medicine Except Principal Investigator Applied pharmacology / Public health/Health science
Keywords	Principal Investigator キサンチンオキシドリダクターゼ / 虚血再灌流障害 / 活性酸素 / 亜硝酸 / キサンチンオキシダーゼ / 虚血再灌流 / キサンチン産生酵素 / 一酸化窒素 / キサンチン酸化還元酵素 / 血管 … More / 国際情報交流　USA / 国際情報交換　USA / インスリン抵抗性 / 白色脂肪細胞 / メタボリックシンドローム / 肥満 / 尿酸産生酵素 / 腎不全 / 脂肪分化 / 尿細管上皮間葉形質転換 / 脂肪 / 腎臓 / 尿酸 … More Except Principal Investigator 高血圧 / トランスポーター / ファーマコゲノミクス / 副作用 / 薬物トランスポーター / 薬理ゲノム学 / ABCG2 / BCRP / ABCC4 / MRP4 / 遺伝子多型 / 尿酸 / 利尿薬 / チアジド / 一般市民 / 久山町研究 / コホート研究 / 一般住民 / 虚血性心疾患 / 脳卒中 / 家庭血圧 Less

The role of nitric oxide derived from xanthine oxidoreductase in renal vascular systemPrincipal Investigator
- Principal Investigator
  
  Ohtsubo Toshio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyushu University
The relationship between trichlormethiazide-induced hyperuricemia and the genotypes of uric acid transporters
- Principal Investigator
  
  TOSHIYUKI Sasaguri
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
Role of xanthine oxidoreductase enzyme and uric acid in ischemic renal damage and metabolic syndromePrincipal Investigator
- Principal Investigator
  
  OHTSUBO Toshio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyushu University
Physiological role of xanthine oxidoreductasePrincipal Investigator
- Principal Investigator
  
  OOTSUBO Toshio
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyushu University
The impact of home blood pressure on cardiovascular events in a general population : the Hisayama Study
- Principal Investigator
  
  KIYOHARA Yutaka
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Public health/Health science
- Research Institution
  Kyushu University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes.2014
- Author(s)
  Murakami, N., Ohtsubo, T., Kansui, Y., Goto, K., Noguchi, H., Haga, Y., Nakabeppu, Y., Matsumura, K., and Kitazono, T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 34 Issue: 1 Pages: 44-51
- DOI
  10.1161/atvbaha.113.302214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-23591195
[Journal Article] Mice heterozygous for the Xanthine Oxidoreductase Gene Facilitate Lipid Accumulation in Adipocytes.2014
- Author(s)
  Murakami N, Ohtsubo T, Kansui Y, Goto K, Noguchi H, Haga Y, Nakabeppu Y, Matsumura K, Kitazono T
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 34 Pages: 44-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591195
[Journal Article] Impact of antihypertensive medication adherence on blood pressure control in hypertension: the COMFORT study.2013
- Author(s)
  Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y, Otonari T, Kawasaki J, Kato I, Tsuchihashi T,; The Comfort Investigators
- Journal Title
  
  QJM
  
  Volume: 106 Issue: 10 Pages: 909-914
- DOI
  10.1093/qjmed/hct121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390140
[Journal Article] Effects of the Superoxide Dismutase Mimetic Tempol on Impaired Endothelium-Dependent and Endothelium-Independent Relaxations in Type II Diabetic Rats.2012
- Author(s)
  Oniki H, Goto K, Fujii K, Kansui Y, Murakami N, Ohtsubo T, Matsumura K, Kitazono T.
- Journal Title
  
  Clin Exp Hypertens
  
  Volume: 35 Pages: 112-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591195
[Journal Article] Upregulation of endothelium-derived hyperpolarizing factor compensates for the loss of nitric oxide in mesenteric arteries of dahl salt-sensitive hypertensive rats.2012
- Author(s)
  Goto K, Kansui Y, Oniki H, Ohtsubo T, Matsumura K, Kitazono T
- Journal Title
  
  Hypertens Res
  
  Volume: 35 Pages: 849-854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591195
[Journal Article] for the COMFORT Investigators. Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?2012
- Author(s)
  Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y, Otonari T, Kawasaki J, Kato I, Tsuchihashi T
- Journal Title
  
  Circ J.
  
  Volume: 76 Pages: 1415-1422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591195
[Journal Article] Association of Body Mass Index with Glomerular Filtration Rate in Japanese: A Cross-Sectional Study in Work-Site Population.2012
- Author(s)
  Kansui Y, Ohtsubo T, Goto K, Oniki H, Yamasaki T, Fukuhara M, Ohta Y, Matsumura K.
- Journal Title
  
  Clin Exp Hypertens.
  
  Volume: 34 Pages: 140-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591195
[Journal Article] Facilitation of sympathetic neurotransmission by phosphatidylinositol-4,5-bisphosphate-dependent regulation of KCNQ channels in rat mesenteric arteries.2012
- Author(s)
  Kansui Y, Goto K, Ohtsubo T, Murakami N, Ichishima K, Matsumura K, Kitazono T.
- Journal Title
  
  Hypertens Res
  
  Volume: 35 Pages: 909-916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591195
[Journal Article] – A Randomized Controlled Trial –2012
- Author(s)
  Matsunura K, Arima H. Toninaga M, Ohtsubo T. Sasaguri T, Fujii K. Fukuhara M, Uezono K, Morinaga Y, Ohta Y Otonari T. Kavasaki J, Kato I, Tsuchihashi T for the COMFORT invest igators
- Journal Title
  
  Circ J
  
  Volume: 76 Issue: 6 Pages: 1415-1422
- DOI
  10.1253/circj.CJ-11-1481
- NAID
  10030316225
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390140
[Journal Article] Xanthine oxidoreductase is a regulator of adipogenesis and PPARγ activity2007
- Author(s)
  Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM.
- Journal Title
  
  Cell Metabolism 5
  
  Pages: 115-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590954
[Journal Article] Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity2007
- Author(s)
  Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM.
- Journal Title
  
  Cell Metab 5
  
  Pages: 115-128
- Data Source
  KAKENHI-PROJECT-19590954
[Journal Article] Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension2007
- Author(s)
  Ohtsubo T, Ohya Y, Nakamura Y, Kansui Y, Furuichi M, Matsumura K, Fujii K, Iida M and Nakabeppu Y
- Journal Title
  
  DNA repair(Amst) 6
  
  Pages: 760-769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] 腎虚血再灌流障害におけるXanthine Oxidoreductaseの役割2015
- Author(s)
  6.芳賀祥江、大坪俊夫、関拓紀、寒水康雄、後藤健一、松村潔、北園孝成
- Organizer
  38回日本高血圧学会総会
- Place of Presentation
  松山
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26461232
[Presentation] ロサルタン/ヒドロクロロチアジド合剤とロサルタン以外のアンジオテンシン受容体拮抗薬およびサイアザイド系利尿薬併用との比較：COMFORT試験2013
- Author(s)
  有馬久富、松村潔、冨永光裕、大坪俊夫、笹栗俊之、藤井弘二、福原正代、上園慶子、守永友希、大田祐子、土橋卓也、COMFORT試験グループ
- Organizer
  第34回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Xanthine Oxidoreductaseは、酸化ストレスを介して腎臓の虚血再灌流障害を引き起こす2013
- Author(s)
  芳賀芳江、村上昇、大坪俊夫、寒水康雄、後藤健一、松村潔、北園孝成
- Organizer
  第３６回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] Xanthine Oxidoreductaseは、酸化ストレスを介して腎臓の虚血再灌流障害を引き起こす2013
- Author(s)
  芳賀祥江、村上昇、大坪俊夫、寒水康雄、後藤健一、松村潔、北園孝成
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] Does a combination pill of antihypertensive drugs improve medication adherence in Japanese? : the COMFORT study2012
- Author(s)
  Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y Otonari T, Kawasaki J, Kato I, Tsuchihashi T for the COMFORT investigators
- Organizer
  24th Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  シドニー
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] COMFORT試験グループ　服薬アドヒアランスが血圧コントロールに及ぼす影響：COMFORT試験サブ解析2012
- Author(s)
  寒水康雄、松村潔、貴田春子、大坪俊夫、笹栗俊之、藤井弘二、福原正代、上園慶子、守永友希、大田祐子、乙成孝俊、川崎純也、土橋卓也、
- Organizer
  第３５回日本高血圧学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] Xanthine oxidoreductaseの発現低下は白色脂肪組織における脂肪合成促進を来し、インスリン抵抗性を伴う肥満を促進する：ＸＯＲ遺伝子改変マウスを用いた検討2012
- Author(s)
  村上昇、大坪俊夫、寒水康雄、後藤健一、松村潔、北園孝成
- Organizer
  第３５回日本高血圧学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] Reduced activity of SKCa channels accounts for the impaired EDHF-mediated relaxation in mesenteric arteries of stroke-prone spontaneously hypertensive rats2012
- Author(s)
  Kenichi Goto, Yasuo Kansui, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari Kitazono
- Organizer
  International Society of Hypertension
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] Heterozygous deletion of xanthine oxidoreducatase augments adipogenesis in white adipose tissue and induces obesity with insulin resistance2012
- Author(s)
  Noboru Murakami, Toshio Ohtsubo, Yasuo Kansui, Kenichi Goto , Kiyoshi Matsumura and Takanari Kitazono
- Organizer
  The 24th Scientific Meeting of the international Society of Hypertension
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] Heterozygous deletion of xanthine oxidoreducatase augments adipogenesis in white adipose tissue and induces obesity with insulin resistance.2012
- Author(s)
  Noboru Murakami, Toshio Ohtsubo, Yasuo Kansui, Kenichi Goto , Kiyoshi Matsumura and Takanari Kitazono
- Organizer
  International Society of Hypertension
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] 加齢におけるxanthine oxidoreductaseの役割：XOR遺伝子改変マウスを用いた検討2012
- Author(s)
  村上昇、大坪俊夫、土橋卓也
- Organizer
  第45回日本痛風・核酸代謝学会総会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] 加齢におけるxanthine oxidoreductaseの役割:XOR遺伝子改変マウスを用いた検討2012
- Author(s)
  村上昇、大坪俊夫、土橋卓也
- Organizer
  第45回日本痛風・核酸代謝学会総会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] Impact of antihypertensive Dedication adherence on blood pressure control in hypertension : the COMFORT study2012
- Author(s)
  Matsuiura K, Anna H, Toninaga M, Ohtsubo T, Sasaguri T, Fujii K Fukuhara M, Dezono K, Norinaga Y, Ohta Y Otonari T, Kawasaki J, Kato I. Tsuchihashi T for the COMFORT investigators
- Organizer
  24 th Scientific Meeting 01 tne International Society of Hyoertension
- Place of Presentation
  シドニー
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] 血管周囲脂肪組織はGuanylate Cyclaseを抑制して一酸化窒素に対する血管弛緩作用を減弱させる2012
- Author(s)
  寒水康雄、後藤健一、大坪俊夫、村上昇、市島久仁彦、松村潔、北園孝成
- Organizer
  第３５回日本高血圧学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] 一酸化窒素合成阻害による血圧上昇におけるキサンチンオキシドリダクターゼ（ＸＯＲ）の役割2011
- Author(s)
  村上昇、大坪俊夫、寒水康雄、後藤健一、松村潔、北園孝成
- Organizer
  第３４回日本高血圧学会総会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] 一酸化窒素合成阻害による血圧上昇におけるキサンチンオキシドリダクターゼ(XOR)の役割:XOR遺伝子改変マウスを用いた検討2011
- Author(s)
  村上昇、大坪俊夫、寒水康雄、後藤健一、松村潔、北園孝成
- Organizer
  第34回日本高血圧学会総会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] 長期高脂肪食負荷による脂肪性肝障害の進行におけるキサンチンオキドリダクターゼ(XOR)の役割2011
- Author(s)
  村上昇、大坪俊夫、土橋卓也東京
- Organizer
  第44回日本痛風・核酸代謝学会総会
- Place of Presentation
  東京
- Year and Date
  2011-02-18
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] Role of xanthine oxidoreductase in high fat diet-induced obesity mice2010
- Author(s)
  Toshio Ohtsubo, Kiyoshi Matsumura, Kenichi Goto, Hideyuki Oniki, Tomoko Ymasaki, Masayo Fukuhara, Yuko Ohta and Mitsuo Iida
- Organizer
  The 23rd Scientific Meeting of the international Society of Hypertension
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] The association between serum uric acid and blood pressure in Japanese men2010
- Author(s)
  Toshio Ohtsubo, Kiyoshi Matsumura, Kenichi Goto, Hideko Noguchi, Hideyuki Oniki, and Mitsuo Iida
- Organizer
  The 23rd Scientific Meeting of the international Society of Hypertension
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-23591195
[Presentation] メタボリックシンドロームモデルマウスにおけるキサンチンオキシドリダクターゼの役割2009
- Author(s)
  大坪俊夫
- Organizer
  第42回日本痛風・核酸代謝学会総会
- Place of Presentation
  東京、京王プラザホテル
- Year and Date
  2009-02-19
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] Xanthine oxidoreductase遺伝子欠損マウスの解析2008
- Author(s)
  大坪俊夫
- Organizer
  第41回日本痛風・核酸代謝学会総会
- Place of Presentation
  福井商工会議所(福井市)
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] メタボリックシンドロームモデルマウスにおけるキサンチンオキシドリダクターゼの役割2008
- Author(s)
  大坪俊夫
- Organizer
  第42回日本痛風・核酸代謝学会総会
- Place of Presentation
  東京
- Year and Date
  2008-02-19
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] Xanthine oxidoreductase遺伝子欠損マウスの解析2008
- Author(s)
  大坪俊夫
- Organizer
  第41回日本痛風・核酸代謝学会総会
- Place of Presentation
  福井
- Year and Date
  2008-02-14
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] キサンチンオキシドリダクターゼ(XOR)と腎虚血再濯流障害-XOR遺伝子欠損マウスを用いて-2008
- Author(s)
  大坪俊夫, 坂上香苗, 松村潔, 飯田三雄
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌、ロイトン札幌
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] Physiological role of xanthine oxidoreductase in kidney2008
- Author(s)
  Toshio Ohtsubo, Kiyoshi Matsumura, Hideko Noguchi and Mitsuo Iida
- Organizer
  The 22nd Scientific Meeting of the international Society of Hypertension
- Place of Presentation
  Berlin, Germany
- Year and Date
  2008-06-16
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] キサンチンオキシドリダクターゼ(XOR)と腎虚血再灌流障害-XOR遺伝子欠損マウスを用いて-2008
- Author(s)
  大坪俊夫、坂上香苗、松村潔、飯田三雄
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] Physiological role of xanthine oxidoreductase in kidney.2008
- Author(s)
  Toshlo Ohtsubo, Kiyoshi Matsumura, Hideko Noguchi, Mitsuo Iida.
- Organizer
  The 22nd Scientific Meeting of theinternational Society of Hypertension.
- Place of Presentation
  Berlin, Germany
- Year and Date
  2008-06-16
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] キサンチンオキシドリダクターゼ遺伝子欠損は尿細管上皮間葉転換を介した腎間質線維化を引き起こす2007
- Author(s)
  大坪俊夫、松村潔、飯田三雄
- Organizer
  第30回日本高血圧学会総会
- Place of Presentation
  沖縄コンベンションゼンター(沖縄)
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] キサンチンオキシドリダクターゼ遺伝子欠損は尿細管上皮間葉転換を介した腎間質線維化を引き起こす2007
- Author(s)
  大坪俊夫、松村潔、飯田三雄
- Organizer
  第30回日本高血圧学会総会
- Place of Presentation
  沖縄
- Year and Date
  2007-10-25
- Data Source
  KAKENHI-PROJECT-19590954
[Presentation] Disruption of xanthine oxidoreductase gene attenuates renal ischemia-reperfusion injury in mice.
- Author(s)
  Yoshie Haga, Toshio Ohtsubo, Noboru Murakami, Yasuo Kansui, Kenichi Goto, Takunori Seki, Kiyoshi Matsumura and Takanari Kitazono
- Organizer
  The 25nd Scientific Meeting of the international Society of Hypertension.
- Place of Presentation
  Athens, Greece
- Year and Date
  2014-06-13 – 2014-06-16
- Data Source
  KAKENHI-PROJECT-26461232
[Presentation] 腎虚血再灌流障害におけるXanthine Oxidoreductaseの２つの働き
- Author(s)
  芳賀祥江、大坪俊夫、土橋卓也
- Organizer
  第48回日本痛風・核酸代謝学会
- Place of Presentation
  東京
- Year and Date
  2015-02-19 – 2015-02-20
- Data Source
  KAKENHI-PROJECT-26461232

1. MATSUMURA Kiyoshi (70285469)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. ARIMA Hisatomi (20437784)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. KIYOHARA Yutaka (80161602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. FUKUHARA Masayo (90360057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TOSHIYUKI Sasaguri (30261209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. MATSUMURA Kiyoshi (70285409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKAHASHI Fumi (50274436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOSHIHARA Tatsuya (80419613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IKEMATU Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIRAISHI Fumie

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HAGA Yoshie

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. MURAKAMI Noboru

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. KANSUI Yasuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. GOTO Kenichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. NOGUCHI Hideko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中別府雄作

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHTSUBO Toshio 大坪 俊夫

Research Projects

Research Products

Co-Researchers

The role of nitric oxide derived from xanthine oxidoreductase in renal vascular systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The relationship between trichlormethiazide-induced hyperuricemia and the genotypes of uric acid transporters

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of xanthine oxidoreductase enzyme and uric acid in ischemic renal damage and metabolic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological role of xanthine oxidoreductasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The impact of home blood pressure on cardiovascular events in a general population : the Hisayama Study

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mice heterozygous for the Xanthine Oxidoreductase Gene Facilitate Lipid Accumulation in Adipocytes.2014

Author(s)

Journal Title

Data Source

[Journal Article] Impact of antihypertensive medication adherence on blood pressure control in hypertension: the COMFORT study.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of the Superoxide Dismutase Mimetic Tempol on Impaired Endothelium-Dependent and Endothelium-Independent Relaxations in Type II Diabetic Rats.2012

Author(s)

Journal Title

Data Source

[Journal Article] Upregulation of endothelium-derived hyperpolarizing factor compensates for the loss of nitric oxide in mesenteric arteries of dahl salt-sensitive hypertensive rats.2012

Author(s)

Journal Title

Data Source

[Journal Article] for the COMFORT Investigators. Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?2012

Author(s)

Journal Title

Data Source

[Journal Article] Association of Body Mass Index with Glomerular Filtration Rate in Japanese: A Cross-Sectional Study in Work-Site Population.2012

Author(s)

Journal Title

Data Source

[Journal Article] Facilitation of sympathetic neurotransmission by phosphatidylinositol-4,5-bisphosphate-dependent regulation of KCNQ channels in rat mesenteric arteries.2012

Author(s)

Journal Title

Data Source

[Journal Article] &ndash; A Randomized Controlled Trial &ndash;2012

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Xanthine oxidoreductase is a regulator of adipogenesis and PPARγ activity2007

Author(s)

Journal Title

Data Source

OHTSUBO Toshio 大坪俊夫

[Journal Article] – A Randomized Controlled Trial –2012

[Presentation] COMFORT試験グループ　服薬アドヒアランスが血圧コントロールに及ぼす影響：COMFORT試験サブ解析2012