SANBE Atsushi 三部篤

Researcher Number	30425706
Other IDs
Affiliation (Current)	2025: 岩手医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2015: 岩手医科大学, 薬学部, 教授 2011: 岩手医科大学, 薬学部, 教授 2010: 独立行政法人国立成育医療研究センター, 薬剤治療研究部, 共同研究員 2009: National Research Institute for Child Health and Development, 薬剤治療研究部, 室長 2008: National Research Institute for Child Health and Development, 薬剤治療研究部実験薬理研究室, 室長 2007 – 2008: National Research Institute for Child Health and Development, 薬剤治療研究部, 室長
Review Section/Research Field	Principal Investigator General pharmacology / Pharmacology in pharmacy Except Principal Investigator General pharmacology
Keywords	Principal Investigator 心筋症 / デスミン / ストレスタンパク質 / 循環 / 熱ショックストレスタンパク質 / ミトコンドリア / ミオパシー / 心不全 / アポトーシス / ストレス … More / 熱ショックタンパク質 / 不溶性凝集体 / バルプロ酸 / HDAC / α-βクリスタリン / HSPB5 / HDAC6 / アグレゾーム / 低分子HSP / α-β-クリスタリン / トランスジェニックマウス / ランスジェニックマウス / アミロイド … More Except Principal Investigator ナトリウム－グルコース共輸送機構１ / ナトリウムーグルコース共輸送機構１ / 心室性不整脈 / 心筋肥大 / 急性虚血 / 高血圧症 / 心不全 / SGLT1 Less

New therapeutic approach of myofibrillar myopathy by mitochondrial protectionPrincipal Investigator
- Principal Investigator
  
  Sanbe Atsushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Iwate Medical University
Relationship between SGLT1 and ventricular arrhythmia
- Principal Investigator
  
  HIROSE MASAMICHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Iwate Medical University
Development of new therapeutic strategy for rescuing cardiomyopathy via inhibition of protein aggregationPrincipal Investigator
- Principal Investigator
  
  SANBE Atsushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Iwate Medical University
  National Research Institute for Child Health and Development
Development of new therapeutic strategy for rescuing cardiomyopathy using small heat shock proteinsPrincipal Investigator
- Principal Investigator
  
  SANBE Atsushi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  National Research Institute for Child Health and Development

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Upregulation of Inorganic pyrophosphatase 1 in hypothyroid embryonic chick cerebellum.2015
- Author(s)
  100)Tezuka Y., Herai N., Inomata Y., Kagami K., Yamauchi J., Nishigori H. and Sanbe A.
- Journal Title
  
  Life Sciences
  
  Volume: 128 Pages: 94-100
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460105
[Journal Article] Molecular mechanisms ofα-crystallinopathy and its therapeutic strategy2011
- Author(s)
  Sanbe A
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 34 Pages: 1653-1658
- Data Source
  KAKENHI-PROJECT-21590299
[Journal Article] Molecular mechanisms of α-crystallinopathy and its therapeutic strategy2011
- Author(s)
  Sanbe A
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 34 Pages: 1653-1658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590299
[Journal Article] Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R12OG transgenic mice2011
- Author(s)
  Sanbe A., et al
- Journal Title
  
  PloS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590299
[Journal Article] Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice2011
- Author(s)
  Sanbe A., Marunouchi T., Yamauchi J., Tanonaka K., Nishigori H. and Akito Tanoue
- Journal Title
  
  PloS One
  
  Volume: 6
- Data Source
  KAKENHI-PROJECT-21590299
[Journal Article] Enhanced Vascular Contractility in Alphal-Adrenergic Receptor-Deficient Mice2009
- Author(s)
  Sanbe A., et al
- Journal Title
  
  Life Sciences 84
  
  Pages: 713-718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590299
[Journal Article] Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.2009
- Author(s)
  Sanbe A., Daicho T., Mizutani R., Endo T., Miyauchi N., Yamauchi J., Tanonaka K., Glabe C. and Tanoue A.
- Journal Title
  
  PloS One 4
  
  Pages: 5351-5351
- Data Source
  KAKENHI-PROJECT-19590266
[Journal Article] Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy2009
- Author(s)
  Sanbe A., et al
- Journal Title
  
  PloS One 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590299
[Journal Article] Inhibitory Effects of Cigarette Smoke Extract on Neural Crest Migration occur through suppression of R-spondin1 expression via Aryl Hydrocarbon Receptor2009
- Author(s)
  Sanbe A., et al
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology 380
  
  Pages: 569-576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590299
[Journal Article] Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy2009
- Author(s)
  Sanbe A., et al.
- Journal Title
  
  PloS One 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590266
[Journal Article] Alpha-1 adrenoceptor is required for normal male sexual function2007
- Author(s)
  Sanbe A., et. al.
- Journal Title
  
  British Journal of Pharmacology 152
  
  Pages: 332-340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590266
[Journal Article] Alcohol preference in mice lacking the Avprla vasopressin receptor
- Author(s)
  Sanbe A., et. al.
- Journal Title
  
  American Journal of Physiology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590266
[Presentation] ストレスタンパク質と心疾患2014
- Author(s)
  三部篤
- Organizer
  第134回日本薬学会年会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-25460105
[Presentation] 低分子ストレスタンパク質によって引き起こされる心臓疾患2014
- Author(s)
  三部篤
- Organizer
  生体機能と創薬誌ポジウム2013
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-25460105
[Presentation] Cardioprotective effect of nicorandil, a mitochondrial potassium channel opener, via modification of mitochondrial permeability transition pore in myofibrilar myopathy.2014
- Author(s)
  Aoyagi T., Yamatoya Y., Natsusaka K., Tezuka Y., Sanbe A.
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25460105
[Presentation] Protein Folding Disease and ATP-sensitive Potassium Channels2014
- Author(s)
  三部篤
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-25460105
[Presentation] アミロイドと心不全2013
- Author(s)
  三部篤
- Organizer
  第23回日本循環薬理学会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-25460105
[Presentation] Nicorandil, a mitochondrial ATP-sensitive potassium channel opener, protects cardiomyocytes against alpha-B-cruystallin R120G-induced apoptosis2012
- Author(s)
  Sanbe A., Koizumi E., Tezuka Y., Nishigori H.
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] Valproic acid can hnhance heart disease in desmin-related cardiomyopathy via impairment of tubulin deacetylation2011
- Author(s)
  Sanbe A., Miyauchi N., Yamauchi J., Nishigori H. and Tanoue A.
- Organizer
  日本薬学会年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] Alpha-Crystallinopathyの病態解明と治療法の開発2011
- Author(s)
  Sanbe A.
- Organizer
  第一回トレンスレーショナル研究会
- Place of Presentation
  福島
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] Alpha-B crystallopathy in the heart.2010
- Author(s)
  Sanbe A.
- Organizer
  XX World Congress International Society for Heart Research
- Place of Presentation
  京都国際会議場
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] Cardiac histone deacetylase 6(HDAC6)activity is critical for disease progression in desmin-related cardiomyopathy2010
- Author(s)
  Sanbe A.
- Organizer
  The 82th Scientific Sessions of American Heart Association
- Place of Presentation
  Chicago IL.USA.
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] Protective Effect of Nicorandil, a Mitochondrial ATP-sensitive Potassium(mK_<ATP>)Channel Opener, on Mitochondrial Impairments Can Prolong Survival in Alpha-Beta-Crystallin R120G Transgenic Mice2010
- Author(s)
  Sanbe A.
- Organizer
  The 82th Scientific Sessions of American Heart Association/Resuscitation Science symposium.
- Place of Presentation
  Chicago IL.USA.
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] Cardiac histone deacetylase 6(HDAC6) activity is critical for disease progression in desmin-related cardiomyopathy2010
- Author(s)
  Sanbe A., Miyauchi N., Nishigori H. and Tanoue A.
- Organizer
  The 82th Scientific Sessions of American Heart Association.
- Place of Presentation
  Chicago IL., USA.
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] ヒストン脱アセチル化酵素(HDAC)阻害薬のデスミン心筋症病態への影響2009
- Author(s)
  Sanbe A.
- Organizer
  第19回循環薬理学会
- Place of Presentation
  京都大学
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] Impairment of tubulin deacetylation can enhance heart disease in desmin-related cardiomyopathy2009
- Author(s)
  Sanbe A., Miyauchi N., Yamauchi J. and Tanoue A.
- Organizer
  The 26th Annual Meeting of ISHR Japanese Section
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] Impairment of tubulin deacetylation can enhance heart disease in desmin-related cardiomyopathy2009
- Author(s)
  Sanbe A.
- Organizer
  The 26th Annual Meeting of ISHR Japanese Section
- Place of Presentation
  北海道大学
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] ヒストン脱アセチル化酵素(HDAC)阻害薬のデスミン心筋症病態への影響2009
- Author(s)
  Sanbe A., Miyauchi N., Yamauchi J. and Tanoue A.
- Organizer
  第19回循環薬理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590299
[Presentation] Protective effects of HSP22 on Desmin related cardiomyopathy2008
- Author(s)
  Sanbe A
- Organizer
  The 25th Annual Meeting of ISHR Japanese Section
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-19590266
[Presentation] Enhancement of HSP22 induction by geranylgeranylacetone (GGA) in desmin-related cardiomyopathy2008
- Author(s)
  Sanbe A
- Organizer
  The 80th Scientific Sessions of American Heart Association. New Orleans, USA
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-19590266
[Presentation] Induction of small heat shock protein by geranylgeranylacetone is protective against CryAB R120G cardiomyopathy P 1072008
- Author(s)
  Sanbe A, Daicho T, Mizutani R, Endo T, Miyauchi N, Yamauchi J, Tanonaka K, Glabe C and Tanoue A.
- Organizer
  International Society for Heart Research (ISHR)
- Place of Presentation
  North American Section meeting, Cincinnati, OH, USA
- Data Source
  KAKENHI-PROJECT-19590266
[Presentation] Enhancement of HSP22 induction by geranylgeranylacetone (GGA) in desmin-related cardiomyopathy.2008
- Author(s)
  Sanbe A, Daicho T, Mizutani R, Endo T, Miyauchi N, Yamauchi J, Tanonaka K, Glabe C and Tanoue A.
- Organizer
  The 80th Scientific Sessions of American Heart Association
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-19590266
[Presentation] Alteration of male sexual function ln alphal A-, 1B- and 1D-adrenergic receptor triple knockout mouse2007
- Author(s)
  Sanbe A.
- Organizer
  7th World Congress on Neurohypophysial Hormones
- Place of Presentation
  Rosenburg, Germany
- Data Source
  KAKENHI-PROJECT-19590266
[Presentation] SGLT1 participates in cardiac remodeling in pressure-overload-induced cardiomyopathy
- Author(s)
  Masamichi Hirose, Naoko Matsushita, Atsushi Sanbe, Sayuri Matsuda, Risa Metoki, Yoshihiro Morino, Hermann Koepsell, Eiichi Taira
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-24590326
[Presentation] 大学院生シンポジウム GS01 循環器疾患に関した新規病態病態制御メカニズムメカニズム-心血管疾患をターゲットとした薬学基礎研究の現状と治療への展望-　「神経筋疾患におけるBCL2関連athanogene 3の機能的役割」
- Author(s)
  猪俣結衣、日野千鶴、手塚優、東尾里英子、青柳利紀、三部篤
- Organizer
  第135回日本薬学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-30
- Invited
- Data Source
  KAKENHI-PROJECT-25460105
[Presentation] Histon deacetylase (HDAC) 6 in cardiac disease. Symposium 1S07 Cardiac Disease-Regenerative Medicine and Drug Development
- Author(s)
  Sanbe Atsushi
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-25460105

1. HIROSE MASAMICHI (40273081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

SANBE Atsushi 三部 篤

Research Projects

Research Products

Co-Researchers

New therapeutic approach of myofibrillar myopathy by mitochondrial protectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relationship between SGLT1 and ventricular arrhythmia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapeutic strategy for rescuing cardiomyopathy via inhibition of protein aggregationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapeutic strategy for rescuing cardiomyopathy using small heat shock proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Upregulation of Inorganic pyrophosphatase 1 in hypothyroid embryonic chick cerebellum.2015

Author(s)

Journal Title

Data Source

[Journal Article] Molecular mechanisms ofα-crystallinopathy and its therapeutic strategy2011

Author(s)

Journal Title

Data Source

[Journal Article] Molecular mechanisms of α-crystallinopathy and its therapeutic strategy2011

Author(s)

Journal Title

Data Source

[Journal Article] Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R12OG transgenic mice2011

Author(s)

Journal Title

Data Source

[Journal Article] Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice2011

Author(s)

Journal Title

Data Source

[Journal Article] Enhanced Vascular Contractility in Alphal-Adrenergic Receptor-Deficient Mice2009

Author(s)

Journal Title

Data Source

[Journal Article] Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.2009

Author(s)

Journal Title

Data Source

[Journal Article] Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy2009

Author(s)

Journal Title

Data Source

[Journal Article] Inhibitory Effects of Cigarette Smoke Extract on Neural Crest Migration occur through suppression of R-spondin1 expression via Aryl Hydrocarbon Receptor2009

Author(s)

Journal Title

Data Source

[Journal Article] Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy2009

Author(s)

Journal Title

Data Source

[Journal Article] Alpha-1 adrenoceptor is required for normal male sexual function2007

Author(s)

Journal Title

Data Source

[Journal Article] Alcohol preference in mice lacking the Avprla vasopressin receptor

Author(s)

Journal Title

Data Source

[Presentation] ストレスタンパク質と心疾患2014

Author(s)

Organizer

Place of Presentation

SANBE Atsushi 三部篤