Nakamura Hideaki 中村秀明

… Alternative Names

NAKAMURA Hideaki 中村秀明

Less

Researcher Number	30435151
Other IDs
Affiliation (Current)	2025: 崇城大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 崇城大学, 薬学部, 准教授 2017 – 2021: 崇城大学, 薬学部, 講師 2013 – 2015: 崇城大学, 薬学部, 助教 2006 – 2010: 崇城大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Physical pharmacy / Pediatrics Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Physical pharmacy / Biological Sciences / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Tumor therapeutics
Keywords	Principal Investigator 腫瘍 / ポリマー / ブラジキニン / 高分子性抗がん剤 / ナノメディシン / HPMAポリマー / 血管 / 血管透過性 / 腫瘍血流 / がん … More / pH応答性 / 抗がん効果 / EPR効果 / 抗腫瘍効果 / 高分子抗がん剤 / 高分子化抗がん剤 / HPMA / 高分子ポリマー / ピラルビシン / すい臓がん / 活性酸素 / FAD / 慢性肉芽腫 / 感染症 / PEG-DAO / 小児感染症学 … More Except Principal Investigator ペプチド / ドラッグデリバリー / DDS / 白血病 / 細胞死 / 中分子薬 / がん / 乳がん / アポトーシス / ペプチド化合物 / ドラッグデリバリーシステム / ペプチドメティック / がん治療 / ネクローシス / リポソーム / 人工酵素 / グルタチオンペルオキシダーぜ / 抗酸化酵素 / セレン / グルタチオンペルオキシダーゼ / セレノール / アセトアミノフェン誘発肝障害 / 抗酸化 / 水酸化フラーレン / 生体内での凝集安定性 / がん光線力学療法 / Sugammadex / フラーレン / 吸着 / 尿毒症 / 慢性腎不全 / フラーレンＣ60 / 吸着炭素 / 抗酸化剤 / 光増感剤 / ナノ粒子 / シクロデキストリン / フラーレンC60 / Tumor imaging / プロトポルフィリン / 腫瘍イメージング / 亜鉛プロトポルフィリン / PDT / NOの寿命 / PEG化医薬 / ナノメディシン / NOの寿命延長 / 水可溶化 / 降圧剤 / 徐放性 / XO阻害剤 / 腫瘍ターゲティング / 腫瘍ターゲラィング / PEG化制癌剤 / 新しい光化学療法 / Znプロトポルフィリン / 腫瘍ターゲッティング / 高分子型制癌剤 / HO-1阻害剤 / HSP32阻害剤 / SMA-ミセル化制癌剤 / HSP-32 / 光増感療法 / PEG-ZnP(亜鉛プロトポルフィリン) / D-アミノ酸酸化酵素 / ZnPP / HSP32 / HO-1 / オキシストレス誘導 / 腫瘍選択性 / 高分子化製剤 / ミセル化製剤 / EPR-効果 Less

ナノメディシンの腫瘍への送達経路を整備する血管作動性ペプチドの開発Principal Investigator
- Principal Investigator
  
  中村秀明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Sojo University
Development of anti-cancer therapy based on cell-selective induction of lysosome membrane permeabilization
- Principal Investigator
  
  國安明彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Sojo University
Synthesis of tumor-selective bradykinin enhancing tumor accumulation of nanomedicinePrincipal Investigator
- Principal Investigator
  
  Hideaki Nakamura
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Sojo University
Development of the necrosis-inducing agents for the drug-resistant tumor treatment
- Principal Investigator
  
  國安明彦
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Sojo University
Synthesis of selenol-bearing membrane-bound antioxidative enzyme and its rescue effect from cell death due to the GPx-4 knockdown
- Principal Investigator
  
  HARATAKE Mamoru
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Sojo University
Augmentation of tumor-target delivery of nanomedicine by an acid-responsive N-(2-hydroxypropyl)methacrylamide-based polymer-bradykinin conjugate.Principal Investigator
- Principal Investigator
  
  Nakamura Hideaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Sojo University
Development of Surface Modified C60 Nanoparticles for a Carbon-Based Nanomedicine
- Principal Investigator
  
  IOHARA Daisuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Sojo University
In vivo evaluation of macromolecular antitumor agent, P-THP, in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Hideaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Sojo University
Design and evaluation of the theranostic potential of tumor-targeted polymeric micelle of zinc protoporphyrin
- Principal Investigator
  
  FANG Jun
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Sojo University
Therapeutic application of PEG-DAO in chronic granulomatous diseasePrincipal Investigator
- Principal Investigator
  
  NAKAMURA Hideaki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Sojo University
Macromolecular anticancer agent, PEGylated Zinc protoporphyrin (ZnP) targeting HSP32
- Principal Investigator
  
  MAEDA Hiroshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sojo University
New miceller agent for antioxidation therapy based on XO inhibition using AHPP
- Principal Investigator
  
  MAEDA Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Sojo University
EPR効果に基づく活性酸素生成型高分子薬の固形癌ターゲティング療法
- Principal Investigator
  
  MAEDA Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sojo University

[Journal Article] Chemical modification of bradykinin-polymer conjugates for optimum delivery of nanomedicines to tumors2024
- Author(s)
  Appiah Enoch、Nakamura Hideaki、Assumang Anthony、Etrych Tomas、Haratake Mamoru
- Journal Title
  
  Nanomedicine: Nanotechnology, Biology and Medicine
  
  Volume: 57 Pages: 102744-102744
- DOI
  10.1016/j.nano.2024.102744
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06704
[Journal Article] Acid-responsive HPMA copolymer-bradykinin conjugate enhances tumor-targeted delivery of nanomedicine2021
- Author(s)
  2.E. Appiah, H. Nakamura, R. Pola, E. Grossmanova, O. Lidicky, A. Kuniyasu, T. Etrych, M. Haratake
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 337 Pages: 546-556
- DOI
  10.1016/j.jconrel.2021.08.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06617, KAKENHI-PROJECT-21K06704, KAKENHI-PROJECT-21K07206
[Journal Article] Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization2020
- Author(s)
  E. Randarova, H. Nakamura, R. Islam, M. Studenovsky, Mamoru Haratake, J. Fang, P. Chytil, T. Etrych
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 106 Pages: 256-266
- DOI
  10.1016/j.actbio.2020.02.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06617, KAKENHI-PROJECT-19K07743
[Journal Article] Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid2019
- Author(s)
  Hideaki Nakamura, Eva Koziolova, Petr Chytil, Tomas Etrych, Mamoru Haratake, Hiroshi Maed
- Journal Title
  
  Molecuar Pharmaceutics
  
  Volume: 16 Issue: 8 Pages: 3452-3459
- DOI
  10.1021/acs.molpharmaceut.9b00248
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06773
[Journal Article] HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases.2016
- Author(s)
  Dozono H, Yanazume S, Nakamura H, Etrych T, Chytil P, Ulbrich K, Fang J, Arimura T, Douchi T, Kobayashi H, Ikoma M, Maeda H.
- Journal Title
  
  Target Oncol
  
  Volume: 11 Issue: 1 Pages: 101-106
- DOI
  10.1007/s11523-015-0379-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860031
[Journal Article] pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect.2016
- Author(s)
  Saisyo A, Nakamura H, Fang J, Tsukigawa K, Greish K, Furukawa H, Maeda H.
- Journal Title
  
  Colloids Surf B Biointerfaces
  
  Volume: 138 Pages: 128-137
- DOI
  10.1016/j.colsurfb.2015.11.032
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860031
[Journal Article] Effect of different chemical bonds in pegylation of zinc protoporphyrin that affects drug release, intracellular uptake, and therapeutic effect in the tumor.2015
- Author(s)
  Tsukigawa K, Nakamura H, Fang J, Otagiri M, Maeda H
- Journal Title
  
  Eur J Pharm Biopharm.
  
  Volume: 89 Pages: 259-270
- DOI
  10.1016/j.ejpb.2014.12.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-26860031, KAKENHI-PROJECT-25430162
[Journal Article] Synthesis and therapeutic effect of styrene-maleic acid copolymer-conjugated pirarubicin.2015
- Author(s)
  Tsukigawa K, Liao L, Nakamura H, Fang J, Greish K, Otagiri M, Maeda H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Issue: 3 Pages: 270-278
- DOI
  10.1111/cas.12592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-26860031
[Journal Article] Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin.2015
- Author(s)
  Fang J, Liao L, Yin H, Nakamura H, Subr V, Ulbrich K, Maeda H.
- Journal Title
  
  Future Sci. OA.
  
  Volume: 1 Issue: 3
- DOI
  10.4155/fso.15.2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430162
[Journal Article] Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls.2015
- Author(s)
  Nakamura H, Jun F, Maeda H.
- Journal Title
  
  Expert opinion on drug delivery
  
  Volume: 12 Issue: 1 Pages: 53-64
- DOI
  10.1517/17425247.2014.955011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860031
[Journal Article] Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice.2015
- Author(s)
  Nakamura H, Koziolova E, Etrych T, Chytil P, Fang J, Ulbrich K, Maeda H.
- Journal Title
  
  European journal of pharmaceutics and biopharmaceutics
  
  Volume: 90 Pages: 90-96
- DOI
  10.1016/j.ejpb.2014.10.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860031
[Journal Article] Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage.2014
- Author(s)
  Nakamura H, Etrych T, Chytil P, Ohkubo M, Fang J, Ulbrich K, Maeda H.
- Journal Title
  
  J Control Release
  
  Volume: 174C Pages: 81-87
- DOI
  10.1016/j.jconrel.2013.11.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430162
[Journal Article] Enhanced Bacterial Tumor Delivery by Modulating the EPR Effect and Therapeutic Potential of Lactobacillus casei.2014
- Author(s)
  Fang J, Liao L, Yin H, Nakamura H, Shin T, Maeda H.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 103 Issue: 10 Pages: 3235-43
- DOI
  10.1002/jps.24083
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430162, KAKENHI-PROJECT-26860031
[Journal Article] Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease.2014
- Author(s)
  Yin H, Fang J, Liao L, Nakamura H, Maeda H.
- Journal Title
  
  J Control Release.
  
  Volume: 187 Pages: 14-21
- DOI
  10.1016/j.jconrel.2014.05.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430162, KAKENHI-PROJECT-26860031
[Journal Article] Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involve suppression of oxidative stress and inflammatory cytokines.2013
- Author(s)
  Fang J, Seki T, Tsukamoto T, Qin H, Yin H, Liao L, Nakamura H, Maeda H.
- Journal Title
  
  Carcinogenesis
  
  Volume: 34 Issue: 12 Pages: 2833-2841
- DOI
  10.1093/carcin/bgt309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430162
[Journal Article] Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)2013
- Author(s)
  Nakamura H, Liao L, Hitaka Y, Tsukigawa K, Subr V, Fang J, Ulbrich K, Maeda H.
- Journal Title
  
  J Control Release
  
  Volume: 165 Issue: 3 Pages: 191-198
- DOI
  10.1016/j.jconrel.2012.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700927, KAKENHI-PROJECT-25430162
[Journal Article] Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo.2013
- Author(s)
  Maeda H, Nakamura H, Fang J. The EPR effect for macromolecular drug delivery to solid tumors
- Journal Title
  
  Adv Drug Deliv Rev.
  
  Volume: 65 Issue: 1 Pages: 71-79
- DOI
  10.1016/j.addr.2012.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700927, KAKENHI-PROJECT-25430162
[Journal Article] Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents ; Unique intracellular disintegration of SMA micelles2011
- Author(s)
  H.Nakamura, J.Fang, B.Gahininath, K.Tsukigawa, H.Maeda
- Journal Title
  
  J.Controlled Release
  
  Volume: (accepted)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents ; Unique intracellular disintegration of SMA micelles2011
- Author(s)
  H.Nakamura, J.Fang, B.Gahininath, K.Tsukigawa, H.Maeda
- Journal Title
  
  J.Controlled Release (accepted)
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] EPR effect : the unique characteristics of tumor blood vessels for drug delivery, factors involved, its limitation and augmentation2011
- Author(s)
  J.Fang, H.Nakamura, H.Maeda
- Journal Title
  
  Advanced Drug Delivery Reviews
  
  Volume: (available online)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] EPR effect: the unique characteristics of tumor blood vessels for drug delivery, factors involved, its limitation and augmentation2010
- Author(s)
  J. Fang, H. Nakamura, H. Maeda
- Journal Title
  
  Adv. Drug Deliv. Rev. (in press)
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] EPR effect : the unique characteristics of tumor blood vessels for drug delivery, factors involved, its limitation and augmentation2010
- Author(s)
  J.Fang, H.Nakamura, H.Maeda
- Journal Title
  
  Adv.Drug Delivery Reviews (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] SMA-copolymer conjugate of AHPP : a polymeric inhibitor of xanthineoxidase with potential antihyper tensive effect2009
- Author(s)
  J.Fang, A.K.Iyer, H.Nakamura, T.Seki, K.Greish, H.Maeda
- Journal Title
  
  J.Cont.Release 135
  
  Pages: 211-217
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] SMA-copolymer conjugate of AHPP : a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect2009
- Author(s)
  J.Fang, A.K.Iyer, H.Nakamura, T.Seki, K.Greish, H.Maeda
- Journal Title
  
  Journal of Controlled Release 135
  
  Pages: 211-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590049
[Journal Article] Oxystress indusing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase.2008
- Author(s)
  J. Fang(1/8番目), H. Nakamura(3/8番目), et al, H. Maeda(8/8番目)
- Journal Title
  
  Int. J. Cancer 122
  
  Pages: 1135-1144
- Data Source
  KAKENHI-PROJECT-20015045
[Journal Article] Oxystress indusing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated d-amino acid oxidase.2008
- Author(s)
  J. Fang, D. Deng, H. Nakamura, T. Akuta, H. Quin, A. Iyer, K. Greish, H. Maeda
- Journal Title
  
  Int. J. Cancer 122
  
  Pages: 1135-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Targeting of heat shock protein 32(Hsp32)/heme oxygenase-I (HO-1) in leukmic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib.2008
- Author(s)
  M. Mayerhofer, K. V. Gleixner, G. HOrmann, K. Sonnecek, K. j. Aichberger, R. G. Ott, K. Greish, H. Nakamura, S. Derdak, P. Samorapoomipichit, w. F. Pickl. V.sexl, H. Esterbauer, C.Sillaber. H. Maeda. P. Valent.
- Journal Title
  
  Blood 111
  
  Pages: 2200-2210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Tumor-targeted induction of oxystress for cancer therapy.2007
- Author(s)
  J. Fang, H. Nakamura & A.K.
- Journal Title
  
  J Drug Targeting 15
  
  Pages: 475-486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Targeting of heat shock protein 32 (Hsp32) / heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia : a novel approach to overcome resistance against imatinib2007
- Author(s)
  M.Mayerhofer, H.Nakamura, V.Sexl, H.Maeda, P.Valent, et al.
- Journal Title
  
  Blood (in press)
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase2007
- Author(s)
  J.Fang, D.Deng, H.Nakamura, T.Akuta, A.K.Iyer, K.Greish, H.Maeda
- Journal Title
  
  Int J Cancer (in press)
- Data Source
  KAKENHI-PROJECT-17016076
[Journal Article] Polymeric xanthine oxidase inhibitor with antiinflammatory and antihypertensive properties : PEG-conjugated micelle of 4-amino-6-hydroxypyrazolo [3,4-d] pyrimidine (AHPP)
- Author(s)
  G.Y.Bharate, J.Fang, H.Nakamura, K.Nakahara, T.Yamaguchi, S.Shinkai, H.Maeda
- Journal Title
  
  J.Drug Targeting (in preparation)
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] 腫瘍への薬物送達経路を整備するポリマー結合型レトロインバーソブラジキニンの合成2024
- Author(s)
  Assumang Anthony, Hideaki Nakamura, Appiah Enoch, Mamoru Haratake
- Organizer
  第144年会日本薬学会
- Data Source
  KAKENHI-PROJECT-21K06704
[Presentation] 抗がん剤の腫瘍集積増強を企図したポリマー結合型レトロインバーソブラジキニンの合成2023
- Author(s)
  中村秀明、Appiah Enoch、Asman Anthony、原武衛
- Organizer
  日本薬学会143年会
- Data Source
  KAKENHI-PROJECT-21K06704
[Presentation] 血中安定性を高めたポリマー結合型レトロインバーソブラジキニンの合成2023
- Author(s)
  Assumang Anthony, Hideaki Nakamura, Appiah Enoch, Tomas Etrych, Mamoru Haratake
- Organizer
  第39回日本DDS学会
- Data Source
  KAKENHI-PROJECT-21K06704
[Presentation] Synthesis and Evaluation of Biological Properties of Retro-inverso Bradykinin2023
- Author(s)
  Assumang Anthony, Hideaki Nakamura, Appiah Enoch, Tomas Etrych, Mamoru Haratake
- Organizer
  第40回薬学会九州山口支部会
- Data Source
  KAKENHI-PROJECT-21K06704
[Presentation] 抗がん剤の腫瘍集積を増強するポリマー結合型レトロインバーソブラジキニンの創製2022
- Author(s)
  堂園健太郎、Appiah Enoch、中村秀明、高橋舎那、中尾恵、仲谷唯、原武衛
- Organizer
  日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-21K06704
[Presentation] pH応答性ポリマー結合型ブラジキニンによる高分子性抗がん剤の腫瘍集積増強作用2022
- Author(s)
  Enoch Appiah, Hideaki Nakamura, Robert Pola, Tomas Etrych, Mamoru Haratake
- Organizer
  日本DDS学会
- Data Source
  KAKENHI-PROJECT-21K06704
[Presentation] 腫瘍指向性高分子化ブラジキニンによる抗がん剤の腫瘍集積増強法2022
- Author(s)
  Enoch Appiah, Hideaki Nakamura, Robert Pola, Kuniyasu Akihiko, Tomas Etrych, Mamoru Haratake
- Organizer
  日本薬学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06704
[Presentation] pH応答性ポリマー結合型ブラジキニンを用いた高分子性抗がん剤の腫瘍集積増強法2021
- Author(s)
  Appiah Enoch、Nakamura Hideaki、Pola Robert、Grossmanova Eliska、Lidicky Ondrej、Kuniyasu Akihiko、Etrych Tomas、Haratake Mamoru
- Organizer
  日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06704
[Presentation] 腫瘍指向性高分子化ブラジキニンによる血流改善に基づく抗がん剤の腫瘍集積増強法2021
- Author(s)
  Appiah Enoch、中村秀明、Pola Robert、Grossmanova Eliska、 Lidicky Ondrej、國安明彦、Etrych Tomas、原武衛
- Organizer
  第38回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-21K07206
[Presentation] 腫瘍指向性高分子化ブラジキニンによる血流改善に基づく抗がん剤の腫瘍集積増強法2021
- Author(s)
  Appiah Enoch、Nakamura Hideaki、Pola Robert、Grossmanova Eliska、Lidicky Ondrej、Kuniyasu Akihiko、Etrych Tomas、Haratake Mamoru
- Organizer
  日本薬学会九州山口支部
- Data Source
  KAKENHI-PROJECT-21K06704
[Presentation] ポリマー結合型ブラジキニンを用いた高分子性抗がん剤の腫瘍集積増強法2021
- Author(s)
  Appiah Enoch、Nakamura Hideaki、Pola Robert、Etrych Tomas、Haratake Mamoru
- Organizer
  第141回日本薬学会
- Data Source
  KAKENHI-PROJECT-18K06773
[Presentation] ポリマー結合型ブラジキニンを用いた腫瘍への薬物送達増強法の検討2020
- Author(s)
  中村秀明、Enoch Appiah、Pola Robert、Etrych Tomas、原武衛
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-18K06773
[Presentation] 血管透過性亢進ペプチドを用いた高分子性抗がん剤のがん組織集積増強法の検討2020
- Author(s)
  Enoch APPIAH、Hideaki NAKAMURA, Robert POLA, Tomas ETRYCH, Mamoru HARATAKE
- Organizer
  日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06617
[Presentation] Bradykinin conjugates of N-（2-hydroxypropyl）methacrylamide based polymer for enhancing tumor delivery of nanomedicines2020
- Author(s)
  Appiah Enoch、中村秀明、Pola Robert、Etrych Tomas、原武衛
- Organizer
  第36回日本DDS学会
- Data Source
  KAKENHI-PROJECT-18K06773
[Presentation] An improvement of tumor drug delivery by conjugation of vasopressin with HPMA polymer2019
- Author(s)
  Appiah Enoch、中村秀明、Robert Pola、Tomas Etrych、原武衛
- Organizer
  日本薬学会九州支部
- Data Source
  KAKENHI-PROJECT-18K06773
[Presentation] An improvement of tumor drug delivery by HPMA based polymer conjugates of vascular permeability enhancing peptide2019
- Author(s)
  Hideaki Nakamura, Enoch Appiah, Robert Pola, Tomas Etrych, Mamoru Haratake
- Organizer
  日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06773
[Presentation] An improvement of tumor drug delivery by HPMA based polymer conjugates of vascular permeability enhancing peptide2019
- Author(s)
  中村　秀明
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06773
[Presentation] 血管透過性亢進ペプチドによる高分子抗がん剤のがん組織デリバリー増強法の検討2019
- Author(s)
  Enoch Appiah, Hideaki Nakamura, Robert Pola, Tomas Etrych, Mamoru Haratake
- Organizer
  日本DDS学会
- Data Source
  KAKENHI-PROJECT-18K06773
[Presentation] 血管透過性増強に基づく高分子性抗癌剤のがん組織集積増強法の検討2019
- Author(s)
  中村　秀明
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06773
[Presentation] 環境応答高分子型抗癌剤（P-THP）の作製と抗癌効果の基礎的検討2016
- Author(s)
  中村　秀明
- Organizer
  臨床腫瘍薬学会
- Place of Presentation
  鹿児島市民ホール（鹿児島県、鹿児島市）
- Year and Date
  2016-03-12
- Data Source
  KAKENHI-PROJECT-26860031
[Presentation] 腫瘍標的型亜鉛プロトポルフィリンP-HPMAミセルを用いる癌光化学治療とイメージング2015
- Author(s)
  方　軍、寥　龍、中村　秀明、Vladimir Subr、Karel Ulbrich、前田　浩
- Organizer
  第３１回日本DDS学会
- Place of Presentation
  京王プラザホテル（東京都、新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation.2015
- Author(s)
  Jun Fang, Hideaki Nakamura, Vladmimir Subr, Karel Ulbrich, Hiroshi Maeda.
- Organizer
  Symposium of 30 Years Anniversary of the EPR Effect: Revolution in Tumor Drug Delivery using Nanomedicine.
- Place of Presentation
  Changchun, P.R.China
- Year and Date
  2015-11-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation2015
- Author(s)
  Jun Fang, Hideaki Nakamura, Vladmimir Subr, Karel Ulbrich, Hiroshi Maeda.
- Organizer
  International conference on Clinical Sciences and Drug Discovery (CSDD-2015)
- Place of Presentation
  Baltimore, MA, USA
- Year and Date
  2015-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] 高分子結合型アントラサイクリン系抗がん剤の比較2015
- Author(s)
  中村　秀明
- Organizer
  日本DDS学会
- Place of Presentation
  京王プラザホテル（東京都、新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26860031
[Presentation] Preparation of a water soluble carbon monoxide donor, SMA-CORM2 micelles, and therapeutic potential for inflammatory bowel diseases.2014
- Author(s)
  Jun Fang, Haibo Qin, Hongzhuan Yin, Hideaki Nakamura, Hiroshi Maeda.
- Organizer
  The 40th Annual Meeting and Exposition of the Controlled Release Society
- Place of Presentation
  Hawaii Convention Center, Honolulu, Hawaii, U.S.A.
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] Evaluation of the targeted photodynamic therapeutic effect of HPMA-zinc protoporphyrin micelle in different tumor models.2013
- Author(s)
  Jun Fang, Long Liao, Hongzhuan Yin, Hideaki Nakamura, Hiroshi Maeda.
- Organizer
  第７２回日本癌学会
- Place of Presentation
  神奈川県、横浜市、パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] 水溶性DDS型COドナーSMAミセルの作製とその抗炎症作用2013
- Author(s)
  方　軍、殷　紅専、寥　龍、中村　秀明、前田　浩
- Organizer
  第２９回日本DDS学会
- Place of Presentation
  京都府、京都市、京都テルサ
- Data Source
  KAKENHI-PROJECT-25430162
[Presentation] Evaluation of (styrene-co-maleic acid) telomer micelles encapsulated-zinc protoporphyrin (SMA-ZnPP) : A stability study for three different types of SMA micelles2011
- Author(s)
  G.Y.Bharate, H.Nakamura, J.Fang, B.Klumperman, S.Shinkai, H.Maeda
- Organizer
  International Conference on Biomaterials Science 2011
- Place of Presentation
  つくば市(茨城県)
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Nanopa rticles of styrene-co-maleic acid (SMA) telomer containing anthracyclin and zinc-protoporphyrin (ZnPP) as new miceller anticancer agents, and SMA conjugate of AHPP, a xanthine oxidase inhibitor for oxystress diseases <Review>2011
- Author(s)
  H.Maeda, H.Nakamura, G.Y.Bharate, K.Tsukigawa, H.Qin, J.Fang
- Organizer
  International Conference on Biomaterials Science 2011
- Place of Presentation
  茨城県(つくば市)
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Nanoparticles of styrene-co-maleic acid (SMA) telomer containing anthracyclin and zinc-protoporphyrin (ZnPP) as new miceller anticancer agents, and SMA conjugate of AHPP, a xanthine oxidase inhibitor for oxystress diseases2011
- Author(s)
  H.Maeda, H.Nakamura, G.Y.Bharate, K.Tsukigawa, H.Qin, J.Fang
- Organizer
  International Conference on Biomaterials Science 2011
- Place of Presentation
  つくば市(茨城県)(Review)
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Evaluation of (styrene-co-maleicacid) telomer micelles encapsulated-zinc protoporphyrin (SMA-ZnPP) : A stability study for three different types of SMA micelles2011
- Author(s)
  G.Y.Bharate, H.Nakamura, J.Fang, B.Klumperman, S.Shinkai, H.Maeda
- Organizer
  International Conference on Biomaterials Science 2011
- Place of Presentation
  茨城県(つくば市)
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Intracellular uptake of water soluble ZnPP micelles (SMA-ZnPP and PEG-ZnPP) and the unique release mechanism of the drug from their micelles.2010
- Author(s)
  中村秀明
- Organizer
  Controlled release society
- Place of Presentation
  Portland, Oregon
- Data Source
  KAKENHI-PROJECT-21791016
[Presentation] ニトロ剤による腫瘍デリバリーの増強とその臨床成績、基礎2010
- Author(s)
  前田浩、方軍、中村秀明、J.Daruwalla
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Nitroglycerin facilitates tumor drug delivery via augmentation of vascular permeability involving NO generation in the hypoxic tumor tissue2010
- Author(s)
  H.Maeda, H.Nakamura, J.Fang
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  京都
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Limitations and augmentations of the EPR effect in solid tumor2010
- Author(s)
  H.Maeda, H.Nakamura, J.Fang
- Organizer
  8^<th> Int'l Symposium Polymer Therapeutic
- Place of Presentation
  バレンシア(スペイン)
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] Limitations and augmentations of the EPR effect in solid tumor2010
- Author(s)
  H.Maeda, H.Nakamura, J.Fang
- Place of Presentation
  スペイン(バレンシア)
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-20590049
[Presentation] 成人T細胞白血病細胞に対するミセル化亜鉛プロトポルフィリンの増殖抑制作用(Growth inhibition of pegylated zinc protoporphyrin(PEG-ZnPP)on adult T-cell leukemia cells)2009
- Author(s)
  覃海波、方軍、中村秀明、前田浩
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] 成人T細胞白血病細胞に対するミセル化亜鉛プロトポルフィリンの増殖抑制作用2009
- Author(s)
  覃海波、方軍、中村秀明、前田浩
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] PEG-ZnPPとSMA-ZnPPの細胞内取り込みとその挙動(Intracellular uptake of pegylated ZnPP(PEG-ZnPP)and poly(styrene-co-maleic acid)micells encapsulated ZnPP(SMA-ZnPP))2009
- Author(s)
  中村秀明等
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20015045
[Presentation] Inhibition of heme oxygenase-1(HO-1) is a novel approach to overcome imatinib resistance in chronic myeloid lekumia.2007
- Author(s)
  中村秀明
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜(日本)
- Data Source
  KAKENHI-PROJECT-17016076
[Presentation] がん組織集積性と酸性環境応答性を併せ持つ高分子型抗がん剤の有用性評価
- Author(s)
  中村　秀明, Tomas Etrych, 方　軍，Karel Ulbrich, 前田　浩
- Organizer
  第8回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  熊本大学　（熊本県熊本市）
- Year and Date
  2014-11-15 – 2014-11-16
- Invited
- Data Source
  KAKENHI-PROJECT-26860031
[Presentation] Improved pharmacokinetics and antitumor activity of poly(N-(2-hydroxypropyl)methacrylamide) conjugates of pirarubicin
- Author(s)
  Nakamura H, Koziolova E, Etrych T, Chytil P, Fang J, Ulbrich K, Maeda H.
- Organizer
  10th International symposium on polymer therapeutics
- Place of Presentation
  Valencia (Spain)
- Year and Date
  2014-05-19 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-26860031
[Presentation] Micelles of CO releasing molecules encapsulated by styrene-maleic acid copolymer, exhibit therapeutic potential for inflammatory bowel disease with disease-targeting property by EPR effect.
- Author(s)
  Jun Fang, Haibo Qin, Hongzhuan Yin, Hideaki Nakamura, Hiroshi Maeda.
- Organizer
  10th International Symposium on Polymer Therapeutics: From laboratory to Clinical Practice.
- Place of Presentation
  Valencia (Spain)
- Year and Date
  2014-05-19 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-25430162

1. FAN Jun (20412736)

# of Collaborated Projects: 4 results

# of Collaborated Products: 36 results
2. MAEDA Hiroshi (90004613)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
3. 國安明彦 (90241348)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 牧瀬正樹 (80433001)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. IOHARA Daisuke (40454954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ANRAKU Makoto (60398245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HARATAKE Mamoru (40325668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 赤池孝章 (20231798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小田切優樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nakamura Hideaki 中村 秀明

NAKAMURA Hideaki 中村 秀明

Research Projects

Research Products

Co-Researchers

ナノメディシンの腫瘍への送達経路を整備する血管作動性ペプチドの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthesis of tumor-selective bradykinin enhancing tumor accumulation of nanomedicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Augmentation of tumor-target delivery of nanomedicine by an acid-responsive N-(2-hydroxypropyl)methacrylamide-based polymer-bradykinin conjugate.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vivo evaluation of macromolecular antitumor agent, P-THP, in pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic application of PEG-DAO in chronic granulomatous diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Chemical modification of bradykinin-polymer conjugates for optimum delivery of nanomedicines to tumors2024

Author(s)

Journal Title

DOI

Data Source

Nakamura Hideaki 中村秀明

NAKAMURA Hideaki 中村秀明