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OHTA Akinobu  太田 明伸

… Alternative Names

Ota Akinobu  太田 明伸

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Researcher Number 30438048
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-6296-2921
Affiliation (Current) 2025: 金城学院大学, 生活環境学部, 教授
Affiliation (based on the past Project Information) *help 2025: 金城学院大学, 生活環境学部, 教授
2023: 金城学院大学, 生活環境学部, 教授
2015 – 2023: 愛知医科大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related / Hematology
Except Principal Investigator
Basic Section 54010:Hematology and medical oncology-related / Basic Section 53030:Respiratory medicine-related / Basic Section 49020:Human pathology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 49030:Experimental pathology-related / Surgical dentistry / Gastroenterology
Keywords
Principal Investigator
悪性化 / 多発性骨髄腫 / 治療標的分子 / ノックアウトマウス / 分子病態 / PBK / ゲノム編集 / 創薬 / セルベースアッセイ / ゲノム異常 … More / 薬剤スクリーニング / 細胞生物学 / マウス / 治療 / トランスレーショナルリサーチ / 治療薬 / 造腫瘍性 / キナーゼ / 分子標的薬 / スクリーニング / 遺伝子発現解析 / 細胞増殖 / GSEA analysis / Gene Ontology analysis / Multiple myeloma / CRISPR/Cas9 / cDNAマイクロアレイ / Interleukin-6 … More
Except Principal Investigator
ゲノム編集 / CRISPR-cas9 / 阻害剤 / cDNAマイクロアレイ / 遺伝子編集技術 / 癌抑制遺伝子 / 悪性胸膜中皮腫 / 嗅受容体 / 癌 / GPCR / CRISPR/Cas9 / 嗅覚受容体 / KIマウス / KOマウス / 精巣 / PBK / 大腸癌 / 標的治療 / 骨髄腫 / gene editing / CRISPR-Cas9 / target therapy / myeloma / RAS / KRAS / BAP1 / 遺伝子変異 / alemtuzumab / ヒト急性白血病 / アレンツムマブ / 化合物ライブラリー / アレンツズマブ / CRISPR-Csa9 / ITD / アレムツズマブ / 白血病 / CD52 / FLT3 / 胸膜中皮腫 / 診断マーカー / ゲノム編集技術 / 侵害受容ニューロン / 筋・組織再生法 / 神経障害性疼痛 / 瘢痕形成 / ノイロトロピン / 遺伝子解析 / 瘢痕性疼痛 / 慢性疼痛 / warburg effect / cancer / olfactory receptor / GCPR / Warburg effect / OR7C1 / CRISPR./Cas9 / 糖代謝 / ワールブルグ効果 / 腫瘍 / マイクロアレイ / ゲノム / 実験腫瘍学 / エナメル上皮腫 / reactive oxygen species / TLR / ameloblastoma / 遺伝子ターゲッティング法 / 細胞増殖能 / 細胞老化 / 内在性遺伝子改変 / CRSPR/Cas9 / TP53遺伝子 / p53アイソフォーム / tumor suppression / cellular senescence / p53beta / delta133p53 / delta40p53 / 肝細胞癌 / p53 isoform / アポトーシス / 細胞周期 / p53β / p53α / 肝癌 / CRSPR/CAS9 / isoform / p53 Less
  • Research Projects

    (14 results)
  • Research Products

    (90 results)
  • Co-Researchers

    (33 People)
  •  ハイリスク多発性骨髄腫におけるFIRRMの機能的意義の解明と新規治療薬の創出Principal Investigator

    • Principal Investigator
      太田 明伸
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kinjo Gakuin University
  •  PBKリン酸化標的遺伝子を介した大腸癌悪性形質制御機構の解析と治療応用の可能性

    • Principal Investigator
      稲熊 真悟
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Nagoya City University
  •  癌・精巣特異的嗅覚受容体を介した癌転移機構の解明と臨床応用

    • Principal Investigator
      武井 則雄
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Hokkaido University
  •  癌抑制遺伝子BAP1を標的とした胸膜中皮種新規阻害薬の開発

    • Principal Investigator
      細川 好孝
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Aichi Medical University
  •  ゲノム編集を利用したKRAS変異骨髄腫に対する新規治療標的薬の探索

    • Principal Investigator
      花村 一朗
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Aichi Medical University
  •  Establishment of the platform for a drug discovery of multiple myeloma by targeting PBK-related signaling pathwayPrincipal Investigator

    • Principal Investigator
      Ota Akinobu
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kinjo Gakuin University
      Aichi Medical University
  •  Research on pathophysiology toward a treatment method for painful scars by regenerating the skeletal muscle system

    • Principal Investigator
      Ushida Takahiro
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Aichi Medical University
  •  Search for diagnostic markers and molecular-targeted compounds for the treatment of malignant mesothelioma

    • Principal Investigator
      Hosokawa Yoshitaka
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Aichi Medical University
  •  Development of the novel target therapy for leukemia with FLT3 mutations, using genetically modified FLT3-mutation knock-in human myeloid leukemia cells

    • Principal Investigator
      Hanamura Ichiro
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Aichi Medical University
  •  Elucidation of the mechanism of action of the olfactory receptor involved in cancer-specific metabolism

    • Principal Investigator
      Takei Norio
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Hokkaido University
  •  Investigation of molecular mechanism by which PBK contributes to tumorigenesis in myeloma cellsPrincipal Investigator

    • Principal Investigator
      Ota Akinobu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Aichi Medical University
  •  The analysis of the p53 isoforms in hepatocellular carcinoma cells using endogenous gene modification.

    • Principal Investigator
      NAKAO HARUHISA
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Aichi Medical University
  •  Genomic diagnosis of ameloblastoma by high-resolution array comparative genomic hybridization and development of molecular target drug

    • Principal Investigator
      KAZAOKA YOSHIAKI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Aichi Medical University
  •  Uncovering malignant mechanisms in multiple myeloma cells using CRISPR/Cas9 systemPrincipal Investigator

    • Principal Investigator
      Ota Akinobu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Aichi Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book Patent

  • [Book] Toxicological Risk Assessment and Multi-System Health Impacts from Exposure 1st edition2021

    • Author(s)
      Ekhtear Hossain, Md Wahiduzzaman, Akinobu Ota
    • Total Pages
      684
    • Publisher
      Elsevier
    • ISBN
      9780323853583
    • Data Source
      KAKENHI-PROJECT-21K08426
  • [Book] Current Understanding of Apoptosis: Arsenic-Based Anticancer-Combined Therapy: Novel Mechanism Inducing Apoptosis of Cancer Cells2018

    • Author(s)
      Ota Akinobu、Wahiduzzaman Md、Hosokawa Yoshitaka
    • Total Pages
      22
    • Publisher
      IntechOpen
    • ISBN
      9781789235012
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Journal Article] ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells.2024

    • Author(s)
      Karnan S, Hanamura I, Ota A, Vu LQ, Uchino K, Horio T, Murakami S, Mizuno S, Rahman ML, Wahiduzzaman M, Hasan MN, Biswas M, Hyodo T, Ito H, Suzuki A, Konishi H, Tsuzuki S, Hosokawa Y, Takami A.
    • Journal Title

      Cell Death Discov.

      Volume: 10(1):56. Issue: 1 Pages: 56-56

    • DOI

      10.1038/s41420-024-01814-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08516, KAKENHI-PROJECT-22K08985, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-21K08427, KAKENHI-PROJECT-21K15579
  • [Journal Article] Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis.2024

    • Author(s)
      Hyodo T, Asano-Inami E, Ito S, Sugiyama M, Nawa A, Rahman ML, Hasan MN, Mihara Y, Lam VQ, Karnan S, Ota A, Tsuzuki S, Hamaguchi M, Hosokawa Y, Konishi H.
    • Journal Title

      FEBS J.

      Volume: 291(5) Issue: 5 Pages: 927-944

    • DOI

      10.1111/febs.17017

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08985, KAKENHI-PROJECT-21K08426
  • [Journal Article] Simultaneous Expression of CD70 and POSTN in Cancer-Associated Fibroblasts Predicts Worse Survival of Colorectal Cancer Patients2024

    • Author(s)
      Komura Masayuki、Wang Chengbo、Ito Sunao、Kato Shunsuke、Ueki Akane、Ebi Masahide、Ogasawara Naotaka、Tsuzuki Toyonori、Kasai Kenji、Kasugai Kunio、Takiguchi Shuji、Takahashi Satoru、Inaguma Shingo
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 5 Pages: 2537-2551

    • DOI

      10.3390/ijms25052537

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K06427, KAKENHI-PROJECT-23K06446
  • [Journal Article] Neurotropin ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response2024

    • Author(s)
      Zhou Xuan、Iida Hiroki、Li Yugiang、Ota Akinobu、Zhuo Lisheng、Nobuhara Reiko、Terajima Yuki、Naiki Mitsuru、Reddi A. Hari、Kimata Koji、Ushida Takahiro
    • Journal Title

      Molecular Pain

      Volume: ND

    • DOI

      10.1177/17448069241245420

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08426
  • [Journal Article] <scp>PDZ</scp> ‐binding kinase inhibitor <scp>OTS514</scp> suppresses the proliferation of oral squamous carcinoma cells2023

    • Author(s)
      Kato Mikako、Ota Akinobu、Ono Takayuki、Karnan Sivasundaram、Hyodo Toshinori、Rahman Md Lutfur、Hasan Muhammad Nazmul、Onda Maho、Kondo Sayuri、Ito Kunihiro、Furuhashi Akifumi、Hayashi Tomio、Konishi Hiroyuki、Tsuzuki Shinobu、Hosokawa Yoshitaka、Kazaoka Yoshiaki
    • Journal Title

      Oral Diseases

      Volume: in press Issue: 2 Pages: 223-234

    • DOI

      10.1111/odi.14533

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08985
  • [Journal Article] CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma2023

    • Author(s)
      Karnan Sivasundaram、Ota Akinobu、Murakami Hideki、Rahman Md. Lutfur、Wahiduzzaman Md、Hasan Muhammad Nazmul、Vu Lam Quang、Hanamura Ichiro、Inoko Akihito、Riku Miho、Ito Hideaki、Kaneko Yoshifumi、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Hosokawa Yoshitaka
    • Journal Title

      Cell Death Discovery

      Volume: 9 Issue: 1 Pages: 257-257

    • DOI

      10.1038/s41420-023-01552-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14488, KAKENHI-PROJECT-22K06988, KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08516, KAKENHI-PROJECT-21K08426
  • [Journal Article] Characterization of colorectal cancer by hierarchical clustering analyses of five immune cell markers2023

    • Author(s)
      Ito Sunao、Koshino Akira、Komura Masayuki、Kato Shunsuke、Otani Takahiro、Wang Chengbo、Ueki Akane、Takahashi Hiroki、Ebi Masahide、Ogasawara Naotaka、Tsuzuki Toyonori、Kasai Kenji、Kasugai Kunio、Takiguchi Shuji、Takahashi Satoru、Inaguma Shingo
    • Journal Title

      Pathology International

      Volume: 74 Issue: 1 Pages: 13-25

    • DOI

      10.1111/pin.13391

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K11791, KAKENHI-PROJECT-23K06427, KAKENHI-PROJECT-23K06446
  • [Journal Article] Long noncoding RNA profile of the intracranial artery in patients with moyamoya disease2023

    • Author(s)
      Mamiya Takashi、Kanamori Fumiaki、Yokoyama Kinya、Ota Akinobu、Karnan Sivasundaram、Uda Kenji、Araki Yoshio、Maesawa Satoshi、Yoshikawa Kazuhiro、Saito Ryuta
    • Journal Title

      Journal of Neurosurgery

      Volume: 138 Issue: 3 Pages: 709-716

    • DOI

      10.3171/2022.5.jns22579

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-20K17961, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-22K08985
  • [Journal Article] Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma.2023

    • Author(s)
      Onda M, Ota A, Ito K, Ono T, Karnan S, Kato M, Kondo S, Furuhashi A, Hayashi T, Hosokawa Y, Kazaoka Y.
    • Journal Title

      Cancer Med.

      Volume: 12(15) Issue: 15 Pages: 16416-16430

    • DOI

      10.1002/cam4.6282

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08985, KAKENHI-PROJECT-21K08426
  • [Journal Article] Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene.2023

    • Author(s)
      Hasan MN, Hyodo T, Biswas M, Rahman ML, Mihara Y, Karnan S, Ota A, Tsuzuki S, Hosokawa Y, Konishi H.
    • Journal Title

      PLoS One.

      Volume: 18(11) Issue: 11 Pages: 16416-16430

    • DOI

      10.1371/journal.pone.0294146

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08294, KAKENHI-PROJECT-22K08985, KAKENHI-PROJECT-21K08426
  • [Journal Article] PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer2022

    • Author(s)
      Koshino Akira、Nagano Aya、Ota Akinobu、Hyodo Toshinori、Ueki Akane、Komura Masayuki、Sugimura-Nagata Akane、Ebi Masahide、Ogasawara Naotaka、Kasai Kenji、Hosokawa Yoshitaka、Kasugai Kunio、Takahashi Satoru、Inaguma Shingo
    • Journal Title

      Frontiers in Pharmacology

      Volume: 12 Pages: 772926-772935

    • DOI

      10.3389/fphar.2021.772926

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K07486, KAKENHI-PROJECT-20K07410, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-19K08668
  • [Journal Article] Correction of a CD55 mutation to quantify the efficiency of targeted knock-in via flow cytometry2022

    • Author(s)
      Rahman Md. Lutfur、Hyodo Toshinori、Hasan Muhammad Nazmul、Mihara Yuko、Karnan Sivasundaram、Ota Akinobu、Tsuzuki Shinobu、Hosokawa Yoshitaka、Konishi Hiroyuki
    • Journal Title

      Molecular Biology Reports

      Volume: - Issue: 7 Pages: 6241-6248

    • DOI

      10.1007/s11033-022-07422-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-22K08985
  • [Journal Article] BCL6 inhibition ameliorates resistance to ruxolitinib in &lt;i&gt;CRLF2&lt;/i&gt;-rearranged acute lymphoblastic leukemia2022

    • Author(s)
      Tsuzuki Shinobu、Yasuda Takahiko、Goto Hiroaki、Maeda Naoko、Akahane Koshi、Inukai Takeshi、Yamamoto Hideyuki、Karnan Sivasundaram、Ota Akinobu、Hyodo Toshinori、Konishi Hiroyuki、Hosokawa Yoshitaka、Kiyoi Hitoshi、Hayakawa Fumihiko
    • Journal Title

      Haematologica

      Volume: 108 Issue: 2 Pages: 394-408

    • DOI

      10.3324/haematol.2022.280879

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-21K19505, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-23K24118, KAKENHI-PROJECT-23K24298, KAKENHI-PROJECT-23K24362
  • [Journal Article] Clostridium butyricum-induced ω-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-λ upregulation2022

    • Author(s)
      Hagihara Mao、Yamashita Makoto、Ariyoshi Tadashi、Eguchi Shuhei、Minemura Ayaka、Miura Daiki、Higashi Seiya、Oka Kentaro、Nonogaki Tsunemasa、Mori Takeshi、Iwasaki Kenta、Hirai Jun、Shibata Yuichi、Umemura Takumi、Kato Hideo、Asai Nobuhiro、Yamagishi Yuka、Ota Akinobu、Takahashi Motomichi、Mikamo Hiroshige
    • Journal Title

      Cell Reports

      Volume: 41 Issue: 11 Pages: 111755-111755

    • DOI

      10.1016/j.celrep.2022.111755

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-22K08591
  • [Journal Article] Plumbagin-induced anticancer effects are associated with mitochondrial- encoded respiratory gene downregulation in oral squamous cell carcinoma.2022

    • Author(s)
      Ono T, Ota A, Kato M, Karnan S, Hyodo T, Rahman ML, Hasan MN, Onda M, Nishio Y, Matsuyama R, Takigawa Y, Kondo S, Ito K, Furuhashi A, Hayashi T, Konishi H, Tsuzuki S, Hosokawa Y, Kazaoka Y
    • Journal Title

      J Oral Maxillofac Surg Med Pathol.

      Volume: 34(6) Pages: 805-812

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K08294
  • [Journal Article] PBK expression predicts favorable survival in colorectal cancer patients2021

    • Author(s)
      Nagano-Matsuo A, Inoue S, Koshino A, Ota A, Nakao K, Komura M, Kato H, Naiki-Ito A, Watanabe K, Nagayasu Y, Hosokawa Y, Takiguchi S, Kasugai K, Kasai K, Inaguma S, Takahashi S
    • Journal Title

      Virchows Archiv

      Volume: - Issue: 2 Pages: 277-284

    • DOI

      10.1007/s00428-021-03062-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07486, KAKENHI-PROJECT-20K07410, KAKENHI-PROJECT-20K16225, KAKENHI-PROJECT-17K08706, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-21K08426
  • [Journal Article] Flow cytometry-based quantification of targeted knock-in events in human cell lines using a GPI-anchor biosynthesis gene <i>PIGP</i>2021

    • Author(s)
      Rahman Md.?Lutfur、Hyodo Toshinori、Hasan Muhammad?Nazmul、Mihara Yuko、Karnan Sivasundaram、Ota Akinobu、Tsuzuki Shinobu、Hosokawa Yoshitaka、Konishi Hiroyuki
    • Journal Title

      Bioscience Reports

      Volume: 41 Issue: 12

    • DOI

      10.1042/bsr20212231

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-19K09292
  • [Journal Article] Transcriptome-wide analysis of intracranial artery in patients with moyamoya disease showing upregulation of immune response, and downregulation of oxidative phosphorylation and DNA repair2021

    • Author(s)
      Kanamori Fumiaki、Yokoyama Kinya、Ota Akinobu、Yoshikawa Kazuhiro、Karnan Sivasundaram、Maruwaka Mikio、Shimizu Kenzo、Ota Shinji、Uda Kenji、Araki Yoshio、Okamoto Sho、Maesawa Satoshi、Wakabayashi Toshihiko、Natsume Atsushi
    • Journal Title

      Neurosurgical Focus

      Volume: 51 Issue: 3 Pages: E3-E3

    • DOI

      10.3171/2021.6.focus20870

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-20K17961, KAKENHI-PROJECT-19K09292
  • [Journal Article] CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia2021

    • Author(s)
      Karnan Sivasundaram、Hanamura Ichiro、Uchino Kaori、Murakami Satsuki、Wahiduzzaman Md、Quang Vu Lam、Rahman Md Lutfur、Hasan Muhammad Nazmul、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Yoshikawa Kazuhiro、Suzuki Susumu、Ueda Ryuzo、Ejiri Masayuki、Hosokawa Yoshitaka、Takami Akiyoshi
    • Journal Title

      Cell Death Discovery

      Volume: 7 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41420-021-00446-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-19K08825, KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-21K08427, KAKENHI-PROJECT-19K09292
  • [Journal Article] Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells2021

    • Author(s)
      Yusuke Azami, Naohiro Tsuyama, Yu Abe, Misaki Sugai-Takahashi, Ken-Ichi Kudo, Akinobu Ota, Karnan Sivasundaram , Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Shigehira Saji, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai.
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 5216-5216

    • DOI

      10.1038/s41598-021-84628-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08738, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-20K21846, KAKENHI-PROJECT-19K17275, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-18H02844, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K11647, KAKENHI-PROJECT-21K07681, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-19K09292
  • [Journal Article] Experimental strategies to achieve efficient targeted knock-in via tandem paired nicking2021

    • Author(s)
      Rahman Md. Lutfur、Hyodo Toshinori、Karnan Sivasundaram、Ota Akinobu、Hasan Muhammad Nazmul、Mihara Yuko、Wahiduzzaman Md、Tsuzuki Shinobu、Hosokawa Yoshitaka、Konishi Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41598-021-01978-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-19K09292
  • [Journal Article] Bi-allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells2020

    • Author(s)
      Kanasugi J, Hanamura I, Ota A, Karnan S, Vu LQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A
    • Journal Title

      Cancer Science

      Volume: - Issue: 5 Pages: 999-999

    • DOI

      10.1111/cas.14386

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-17K07263
  • [Journal Article] Identification of cisplatin-resistant factor by integration of transcriptomic and proteomic data using head and neck carcinoma cell lines2020

    • Author(s)
      Inukai D, Nishimura K, Okamoto H, Sano R, Ueda H, Ota A, Karnan S, Hosokawa Y, Yoshikawa K, Suzuki S, Ueda R, Murotani K, Bradford CR, Ogawa T
    • Journal Title

      Nagoya Journal of Medical Science

      Volume: 82 Issue: 3 Pages: 519-531

    • DOI

      10.18999/nagjms.82.3.519

    • NAID

      120006881553

    • ISSN
      2186-3326
    • URL

      https://nagoya.repo.nii.ac.jp/records/30422

    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K18327, KAKENHI-PROJECT-18K08342
  • [Journal Article] CRISPR-Casシステムを用いた骨髄腫の悪性化に関わる分子機構の解明2020

    • Author(s)
      太田明伸, 花村一朗, 細川好孝
    • Journal Title

      Precision Medicine

      Volume: 4(1) Pages: 60-64

    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Journal Article] Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells2020

    • Author(s)
      Ota Akinobu、Hanamura Ichiro、Karnan Sivasundaram、Inaguma Shingo、Takei Norio、Lam Vu Quang、Mizuno Shohei、Kanasugi Jo、Wahiduzzaman Md、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Ikeda Hiroshi、Takami Akiyoshi、Hosokawa Yoshitaka
    • Journal Title

      Journal of Interferon & Cytokine Research

      Volume: 40 Issue: 8 Pages: 389-405

    • DOI

      10.1089/jir.2020.0111

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K07060, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-20K06613, KAKENHI-PROJECT-17K07263
  • [Journal Article] Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma2020

    • Author(s)
      Kondo Sayuri、Ota Akinobu、Ono Takayuki、Karnan Sivasundaram、Wahiduzzaman Md、Hyodo Toshinori、Lutfur Rahman Md、Ito Kunihiro、Furuhashi Akifumi、Hayashi Tomio、Konishi Hiroyuki、Tsuzuki Shinobu、Hosokawa Yoshitaka、Kazaoka Yoshiaki
    • Journal Title

      Cancer Medicine

      Volume: 9 Issue: 8 Pages: 2904-2917

    • DOI

      10.1002/cam4.2931

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
  • [Journal Article] CRISPR-Casシステムを用いたゲノム編集と骨髄腫の新たな悪性化因子の同定2020

    • Author(s)
      太田明伸, 花村一朗, 細川好孝
    • Journal Title

      Precision Medicine

      Volume: 3(6) Pages: 571-575

    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Journal Article] Novel mechanistic insights into the anti-cancer mode of arsenic trioxide2020

    • Author(s)
      Wahiduzzaman M, Ota A, Hosokawa Y.
    • Journal Title

      Current Cancer Drug Targets

      Volume: 20(2) Issue: 2 Pages: 115-129

    • DOI

      10.2174/1568009619666191021122006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Journal Article] Interferon-γ-induced HLA Class II expression on endothelial cells is decreased by inhibition of mTOR and HMG-CoA reductase2020

    • Author(s)
      Maenaka A, Kenta I, Ota A, Miwa Y, Ohashi W, Horimi K, Matsuoka Y, Ohnishi M, Uchida K, Kobayashi T
    • Journal Title

      FEBS Open Bio

      Volume: - Issue: 5 Pages: 927-936

    • DOI

      10.1002/2211-5463.12854

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K19593, KAKENHI-PROJECT-19K09680
  • [Journal Article] Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma2020

    • Author(s)
      KarnanS, Ota A, Murakami H, Rahman ML, Hasan  MN, Wahiduzzaman MD, Hanamura I, Vu LQ, Inoko A, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y.
    • Journal Title

      Cell Death Discovery

      Volume: 18 Issue: 1 Pages: 127-139

    • DOI

      10.1038/s41420-020-00364-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K07031, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-20K06613, KAKENHI-PROJECT-17K07263
  • [Journal Article] Establishment of a mouse model for injury-induced scar formation and the accompanying chronic pain: Comprehensive microarray analysis of molecular expressions in fibrosis and hyperalgesia.2019

    • Author(s)
      Li Y, Iida H, Kimata K, Zhuo L, Ota A, Kimura S, Yin X, Deie M, Ushida T.
    • Journal Title

      Molecular Pain

      Volume: - Pages: 174480691989238-174480691989238

    • DOI

      10.1177/1744806919892389

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-19K07853
  • [Journal Article] Establishment and characterization of CRISPR/Cas9-mediated NF2-/- human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma.2019

    • Author(s)
      Wahiduzzaman M, Karnan S, Ota A, Hanamura I, Murakami H, Inoko A, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y.
    • Journal Title

      Cancer Science

      Volume: 110 Pages: 180-193

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08668
  • [Journal Article] 多発性骨髄腫の進展に関わる分子機構とPBKの関与2019

    • Author(s)
      太田 明伸, 花村 一朗
    • Journal Title

      BIO Clinica

      Volume: 34(6) Pages: 86-92

    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Journal Article] Tandem paired nicking promotes precise genome editing with scarce interference by p532019

    • Author(s)
      Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H.
    • Journal Title

      Cell Rep.

      Volume: 30 Issue: 4 Pages: 1195-1207

    • DOI

      10.1016/j.celrep.2019.12.064

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-19J40240, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
  • [Journal Article] 多発性骨髄腫におけるPBK 発現の意義と 治療標的としての可能性2019

    • Author(s)
      太田明伸,花村一朗,細川好孝
    • Journal Title

      BIO Clinica

      Volume: 34(13) Pages: 65-69

    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Journal Article] Establishment and characterization of CRISPR/Cas9-mediated NF2(-/-) human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma2019

    • Author(s)
      Wahiduzzaman Md、Karnan Sivasundaram、Ota Akinobu、Hanamura Ichiro、Murakami Hideki、Inoko Akihito、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Hosokawa Yoshitaka
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 1 Pages: 180-193

    • DOI

      10.1111/cas.13871

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
  • [Journal Article] 多発性骨髄腫の進展に関わる分子機構とPBKの関与2019

    • Author(s)
      太田明伸、花村一朗
    • Journal Title

      BIO Clinica

      Volume: 451 Pages: 86-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Journal Article] ゲノム編集法を用いた骨髄腫の悪性化に関わる分子機構の解析2019

    • Author(s)
      太田 明伸, 細川好孝
    • Journal Title

      Medical Science Digest

      Volume: 45(9) Pages: 8-11

    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Journal Article] Inhibition of NADPH oxidase 2 induces apoptosis in osteosarcoma: The role of reactive oxygen species in cell proliferation2018

    • Author(s)
      Kitamoto Kazumasa、Miura Yuji、Karnan Sivasundaram、Ota Akinobu、Konishi Hiroyuki、Hosokawa Yoshitaka、Sato Keiji
    • Journal Title

      Oncology Letters

      Volume: 15 Pages: 7955-7962

    • DOI

      10.3892/ol.2018.8291

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07263
  • [Journal Article] The plant alkaloid conophylline inhibits matrix formation of fibroblasts2018

    • Author(s)
      Tezuka Takehiko、Ota Akinobu、Karnan Sivasundaram、Matsuura Katsuhiko、Yokoo Kazuhisa、Hosokawa Yoshitaka、Vigetti Davide、Passi Alberto、Hatano Sonoko、Umezawa Kazuo、Watanabe Hideto
    • Journal Title

      Journal of Biological Chemistry

      Volume: 293 Issue: 52 Pages: 20214-20226

    • DOI

      10.1074/jbc.ra118.005783

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18H02646
  • [Journal Article] Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo2018

    • Author(s)
      Wahiduzzaman Md、Ota Akinobu、Karnan Sivasundaram、Hanamura Ichiro、Mizuno Shohei、Kanasugi Jo、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Takami Akiyoshi、Hosokawa Yoshitaka
    • Journal Title

      Cancer Letters

      Volume: 433 Pages: 117-130

    • DOI

      10.1016/j.canlet.2018.06.027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-17K07263
  • [Journal Article] Establishment and characterization of a novel vincristine-resistant diffuse large B-cell lymphoma cell line containing the 8q24 homogeneously staining region2018

    • Author(s)
      Mizuno S、Hanamura I、Ota Akinobu、Karnan S、Kanasugi J、Nakamura A、Takasugi S、Uchino Ki、Horio T、Goto、Murakami S、Gotou M、Yamamoto H、Watarai M、Shikami M、Hosokawa Y、Miwa H、Taniwaki M、Ueda R、Nitta M、Takami A
    • Journal Title

      FEBS Open Bio

      Volume: 8 Issue: 12 Pages: 1977-1991

    • DOI

      10.1002/2211-5463.12538

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-16K09856
  • [Journal Article] Generation of PTEN?knockout (-/-) murine prostate cancer cells using the CRISPR/Cas9 system and comprehensive gene expression profiling2018

    • Author(s)
      Takao Akiko、Yoshikawa Kazuhiro、Karnan Sivasundaram、Ota Akinobu、Uemura Hirotsugu、De Velasco Marco、Kura Yurie、Suzuki Susumu、Ueda Ryuzo、Nishino Tokiko、Hosokawa Yoshitaka
    • Journal Title

      Oncology Reports

      Volume: 40 Pages: 2455-2466

    • DOI

      10.3892/or.2018.6683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11165, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K11301
  • [Journal Article] Versican A-subdomain is required for its adequate function in dermal development.2017

    • Author(s)
      Hatano S, Nagai N, Sugiura N, Tsuchimoto J, Isogai z, Kimata K, Ota A, Karnan S, Hosokawa Y, Watanabe H
    • Journal Title

      Connect Tissue Res

      Volume: 印刷中 Issue: 2 Pages: 178-190

    • DOI

      10.1080/03008207.2017.1324432

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293096, KAKENHI-PROJECT-15K19561, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-17K07352
  • [Journal Article] Delta40p53 suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells2017

    • Author(s)
      Ota A, Nakao H, Sawada Y, Karnan S, Wahiduzzaman M, Inoue T, Kobayashi Y, Yamamoto T, Ishii N, Ohashi T, Nakade Y, Sato K, Itoh K, Konishi H, Hosokawa Y, Yoneda M
    • Journal Title

      J Cell Sci

      Volume: 130 Issue: 3 Pages: 614-625

    • DOI

      10.1242/jcs.190736

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-15K19561, KAKENHI-PROJECT-16K09381, KAKENHI-PROJECT-17K09442, KAKENHI-PROJECT-17K07263
  • [Journal Article] Inhibition of Nox1 induces apoptosis by attenuating the AKT signaling pathway in oral squamous cell carcinoma cell lines2016

    • Author(s)
      Ito K, Ota A, Ono T, Nakaoka T, Wahiduzzaman M, Karnan S, Konishi H, Furuhashi A, Hayashi T, Yamada Y, Hosokawa Y, and Kazaoka Y
    • Journal Title

      Oncol Rep

      Volume: 36 Issue: 5 Pages: 2991-2998

    • DOI

      10.3892/or.2016.5068

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-15K19561
  • [Journal Article] Improved methods of AAV-mediated gene targeting for human cell lines using ribosome-skipping 2A peptide2016

    • Author(s)
      Karnan S, Ota A, Konishi Y, Wahiduzzaman M, Hosokawa Y, and Konishi H
    • Journal Title

      Nucleic Acids Research

      Volume: 44 Issue: 6 Pages: e54-e54

    • DOI

      10.1093/nar/gkv1338

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107, KAKENHI-PROJECT-15K19561
  • [Journal Article] Overexpression of salivary-type amylase reduces the sensitivity to bortezomib in multiple myeloma cells2015

    • Author(s)
      Mizuno, S., Hanamura, I., Ota, A., Karnan, S., Narita, T., Ri, M., Mizutani, M., Goto, M., Gotou, M., Tsunekawa, N., Shikami, M., Iida, S., Hosokawa, Y., Miwa, H., Ueda, R., Nitta, M. and Takami, A
    • Journal Title

      Int J Hematol

      Volume: 102 Issue: 5 Pages: 569-78

    • DOI

      10.1007/s12185-015-1859-0

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09513, KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-15K19561
  • [Patent] RAS遺伝子変異体癌治療薬2022

    • Inventor(s)
      シバスンダラン カルナン、太田 明伸、花村 一朗、細川 好孝
    • Industrial Property Rights Holder
      シバスンダラン カルナン、太田 明伸、花村 一朗、細川 好孝
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-169541
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-21K08426
  • [Patent] 悪性中皮腫の治療薬2021

    • Inventor(s)
      シバスンダラン カルナン、太田 明伸、細川 好孝
    • Industrial Property Rights Holder
      シバスンダラン カルナン、太田 明伸、細川 好孝
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-169563
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-21K08426
  • [Presentation] DISCOVERY OF NOVEL TARGETED DRUGS FOR K-RAS-MUTATED MYELOMA USING ISOGENIC K-RASMUTANT CELLS2024

    • Author(s)
      Ichiro Hanamura, Karnan Sivasundaram, Akinobu Ota, Keichiro Mihara, Yoshitaka Hosokawa, Akiyoshi Takami
    • Organizer
      EHA2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08516
  • [Presentation] A Rapid and Sensitive FCM-Based Assay for Monitoring CRISPR/Cas9 Genome Editing in L1CAM Gene2023

    • Author(s)
      Muhammad Nazmul Hasan, Toshinori Hyodo, Mrityunjoy Biswas, Md. Lutfur Rahman, Yuko Mihara, Sivasundaram Karnan, Akinobu Ota, Shinobu Tsuzuki, Yoshitaka Hosokawa, and Hiroyuki Konishi
    • Organizer
      第46回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-21K08426
  • [Presentation] LUZP1, a novel CPC colocalizing protein, regulates the constriction velocity of the contractile ring during cytokinesis.2023

    • Author(s)
      Toshinori Hyodo, Muhammad Nazmul Hasan, Mrityunjoy Biswas, Eri Inami, Sivasundaram Karnan, Akinobu Ota, Shinobu Tsuzuki, Yoshitaka Hosokawa, Hiroyuki Konishi.
    • Organizer
      第46回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-21K08426
  • [Presentation] Generation and analysis of Olfactory receptor Knock-out and Knock-in mice.2023

    • Author(s)
      武井 則雄, 太田明伸, 桜井敬之
    • Organizer
      第8回 日本ゲノム編集学会
    • Data Source
      KAKENHI-PROJECT-23K07801
  • [Presentation] PBK阻害剤OTS514は口腔扁平上皮癌細胞においてE2F標的遺伝子の下方制御と細胞増殖を抑制する2023

    • Author(s)
      太田 明伸、カルナン シバスンラダン、小西 裕之、都築 忍、細川 好孝、風岡 宜暁
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K08426
  • [Presentation] 慢性疼痛によるマウス有痛性瘢痕モデルにおける損傷組織部位へのノイロトロピン直接投与の効果2022

    • Author(s)
      周 軒, 飯田 博己, 木全 弘治, 李 玉強, 太田 明伸, 牛田 享宏
    • Organizer
      第95回日本生化学学会
    • Data Source
      KAKENHI-PROJECT-19K07853
  • [Presentation] Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia2022

    • Author(s)
      Shinobu Tsuzuki, Takahiko Yasuda, Masahito Kawazu, Toshihide Ueno, Sivasundaram Karnan, Akinobu Ota, Masashi Sanada, Hirokazu Nagai, Akihiro Tomita, Yoshiyuki Takahashi, Yasushi Miyazaki, Itaru Matsumura, Hitoshi Kiyoi, Yoshitaka Hosokawa, Hiroyuki Mano, Fumihiko Hayakawa
    • Organizer
      日本癌学会
    • Data Source
      KAKENHI-PROJECT-21K08426
  • [Presentation] ゲノム編集法を用いた不死化ヒト中皮細胞株の形質転換に関わる分子機構の解析と悪性中皮腫に対する新規治療標的分子の探索2021

    • Author(s)
      太田 明伸、シバスンダラン カルナン、細川 好孝
    • Organizer
      第2回日本石綿・中皮腫学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08426
  • [Presentation] Tandem paired nicking法による高精度でDNA損傷反応を誘起しない塩基置換の特性解析2021

    • Author(s)
      小西裕之, 兵頭寿典, Md. Lutfur Rahman, Muhammad Nazmul Hasan, 三原 優子, Sivasundaram Karnan, 太田 明伸, 都築 忍, 細川 好孝. Tandem paired nicking法による高精度でDNA損傷反応を誘起しない塩基置換の特性解析
    • Organizer
      日本ゲノム編集学会第6回大会
    • Data Source
      KAKENHI-PROJECT-21K08426
  • [Presentation] CD52 is a novel target for the treatment of FLT3-ITD mutated leukemia2021

    • Author(s)
      花村 一朗, カルナン シバンスンダラン, 太田 明伸, 鈴木 進, 高杉 壮一, 中村 文乃, 高橋 美裕希, 村上 五月, 上田 龍三, 細川 好孝, 高見 昭良
    • Organizer
      第83回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08825
  • [Presentation] Deletion of Pbk Locus by using CRISPR/Cas9-based gene editing without apparent phenotype in C57BL/6 Mice2020

    • Author(s)
      武井則雄, 太田明伸, シバスンダランカルナン, 稲熊真悟, 細川好孝
    • Organizer
      日本動物学会第91回大会
    • Data Source
      KAKENHI-PROJECT-18K07060
  • [Presentation] ノイロトロピンの疼痛緩和効果に関わる遺伝子発現変化の網羅的解析2020

    • Author(s)
      飯田博己, 李玉強,木全弘治,太田明伸,周軒,木村伸也,牛田享宏
    • Organizer
      第42回日本疼痛学会
    • Data Source
      KAKENHI-PROJECT-19K07853
  • [Presentation] Identification of Genome-wide Molecular Characteristics in Ameloblastoma:Role of Tlr2 in Ameloblastoma Cells2019

    • Author(s)
      S.Kondo, A.Ota, T.Ono, S.Karnan, M.Wahiduzzaman, T.Hyodo, M.L.Rahman, K.Ito, A.Furuhashi, T.Hayashi, H.Konishi, S.Tuzuki, Y.Hosokawa, Y.Kazaoka
    • Organizer
      ASCB/EMBO 2019 Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] CRISPRCas9を用いたNF2及びCDKN2Aノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析2019

    • Author(s)
      Sivasundaram Karnan, Akinobu ota, Ichiro Hanamura, Hideki Murakami, Toshinori Hyodo, Wahiduzzanan Md, Hiroyuki Konishi , Shinobu Tsuzuki, Yoshitaka Hosokawa
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] CRISPR/Cas9 nickase によるサイレント変異不要のノックイン2019

    • Author(s)
      兵頭寿典、Md Lutfur Rahman、豊田敦、Sivasundaram Karnan、太田明伸、都築忍、 細川好孝、小西裕之
    • Organizer
      第4回日本ゲノム編集学会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] 骨髄腫細胞におけるPBZ binding kinaseの腫瘍促進作用と治療標的分子としての可能性2019

    • Author(s)
      太田明伸、花村一朗、Karnan Sivasundaram、高見昭良、細川好孝
    • Organizer
      第44回日本骨髄腫学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] Biallelic Loss of FAM46C Promotes the Proliferation of Multiple Myeloma Cells with Concomitant Upregulation of P13K-AKT Signaling2019

    • Author(s)
      Jo Kanasugi, Ichiro Hanamura, Akinobu Ota, Sivasundaram Karnan, Lam Quang Vu, Yoshitaka Hosokawa, Akiyoshi Takami
    • Organizer
      第10回日本血液学会(JSH)国際シンポジウム
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] Role of PBK in multiple myeloma cell growth: implication of PBK in novel molecular targets for anti-myeloma therapy2019

    • Author(s)
      太田明伸, 花村一朗, KARNAN Sivasundaram, 高見昭良, 細川好孝
    • Organizer
      第44回日本骨髄腫学会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定2019

    • Author(s)
      シバスンダラン カルナン、太田明伸、花村一朗、村上秀樹、兵頭寿典、小西裕之、 都築忍、細川好孝
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] Chromosomal translocation t(11;14) and p53 deletion in B cell-derived iPS cells by CRISPR/Cas92019

    • Author(s)
      Aki Yanagi, Naohiro Tsuyama, Misaki Sugai, Yu Abe, Yukari Yanai, Akinobu Ota, Karnan Sivasundaram, Lobna Alkebsi, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, Yuko Hashimoto, Kenji Kamiya, Ichiro Hanamura, Takayuki Ikezoe, Masafumi Onodera, Akira Sakai.
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] Introduction of Chromosomal Translocation t(11; 14) and a p53 Deletion into Normal B Cell-derived iPSCs to Elucidate the Cellular Origin of Myeloma Cells.2019

    • Author(s)
      Yanagi A, Tsuyama N, Sugai M, Abe Y, Azami Y, Yanai Y, Ota A, Sivasundaram K, Muramatsu M, Shigemura T, Sasatani M, Hashimot Y, Kamiya K, Hanamura I, Ikezoe T, Onodera M, Sakai A.
    • Organizer
      61th ASH Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] DNA二重鎖切断を介さない変異ノックイン法(Targeted knock-in without introducing double-stranded DNA breaks)2019

    • Author(s)
      兵頭寿典、Md Lutfur Rahman、豊田敦、Sivasundaram Karnan、太田明伸、都築忍、 細川好孝、小西裕之
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] Tandem paired nicking using Cas9 nickases permits targeted knock-in without significant inhibition by p532019

    • Author(s)
      Toshinori Hyodo, Md Lutfur Rahman, Atsushi Toyoda, Sivasundaram Karnan, Akinobu Ota, Shinobu Tuzuki, Yoshitaka Hosokawa, Hiroyuki Konishi
    • Organizer
      Frontiers in Genome Engineering 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] CRISPR/Cas9 nickaseによるノックインはp53を活性化しない2019

    • Author(s)
      兵頭寿典、Md Lutfur Rahman、Sivasundaram Karnan、太田明伸、都築忍、細川好孝、 小西裕之
    • Organizer
      第4回日本ゲノム編集学会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] Experimental conditions permitting efficient targeted koock-in using CRISPR/Cas9 nickase2019

    • Author(s)
      Md Lutfur Rahman, Toshinori Hyodo, Sivasundaram Karnan, Akinobu Ota, Shinobu Tsuzuki, Yoshitaka Hosokawa, Hiroyuki Konishi
    • Organizer
      第4回日本ゲノム編集学会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] 骨髄腫細胞のレナリドマイド耐性に関連する付加的ゲノム異常と遺伝子発現変化の基礎的検討2018

    • Author(s)
      太田明伸, 花村一朗, KARNAN Sivasundaram, 高見昭良, 細川好孝
    • Organizer
      第43回日本骨髄腫学会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] Delta40p53 suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells.2018

    • Author(s)
      Haruhisa Nakao, Akinobu Ota, Yumi Sawada, Sivasundaram Karnan, Md Wahiduzzaman, Tadashi Inoue, Yuji Kobayashi,Norimitsu Ishii, Tomohiko Ohashi, Yukiomi Nakade, Yoshio Sumida, Kiyoaki Itoh, Hiroyuki Konishi, Yoshitaka Hosokawa, Masashi Yoneda
    • Organizer
      the European Association for the Study of Liver: The International Liver Congress 2018 in Paris
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09381
  • [Presentation] 内在性遺伝子改変法を用いた肝癌におけるp53 splicing isoformの機能解析2018

    • Author(s)
      中尾春壽 , 太田明伸 , 北野礼奈 , 坂本和賢 , 大橋知彦 , 中出幸臣 , 角田圭雄 , 伊藤清顕 , 米田政志
    • Organizer
      第54回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-16K09381
  • [Presentation] 多発性骨髄腫の腫瘍増殖におけるPDZ binding kinaseの関与2018

    • Author(s)
      太田明伸、花村一朗、シバスンダラン カルナン、小西裕之、都築忍、細川好孝
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] 悪性中皮腫細胞の増殖を特異的に抑制するAkt阻害剤の探索と同定2018

    • Author(s)
      太田明伸、山地 雅之、 ワヒドッジャマン ムハマド、シバスンダラン カルナン、 兵頭 寿典、小西 裕之、都築 忍、羽生田 正行、細川 好孝
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] P16/NF2 遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定2018

    • Author(s)
      シバスンダラン カルナン、太田明伸、花村一朗、村上秀樹、 ムハマド ワヒドッジャマン、兵頭寿典、小西裕之、都築忍、細川好孝
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K08342
  • [Presentation] Delta133p53, One of the p53 Isoforms, Suppresses Tumor Cell Proliferation and Induces Cellular Senescence in Hepatocellular Carcinoma Cells2018

    • Author(s)
      Haruhisa Nakao, Akinobu Ota, Mayu Ibusuki, Rena Kitano, Satoshi Kimoto, Tomohiko Ohashi, Yukiomi Nakade, Yoshio Sumida, Kiyoaki Itoh, Hiroyuki Konishi, Yoshitaka Hosokawa, Masashi Yoneda
    • Organizer
      the American Association for the Study of Liver Diseases. : The Liver Meeting&reg; 2018 in San Francisco
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09381
  • [Presentation] delta40p53(p53蛋白質splicing isoform)の肝細胞癌における機能解析2017

    • Author(s)
      中尾春壽、太田明伸、坂本和賢、山本高也、大橋知彦、中出幸臣、角田圭雄、伊藤清顕、米田政志
    • Organizer
      第53回日本肝臓学会 総会
    • Data Source
      KAKENHI-PROJECT-16K09381
  • [Presentation] 遺伝子ターゲティング法を用いたp53蛋白質splicing isoformの肝細胞癌における機能解析2016

    • Author(s)
      中尾春壽、太田明伸、山本高也
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-16K09381
  • [Presentation] 肝がん細胞株におけるp53アイソフォームdelta40p53の性状解析2016

    • Author(s)
      太田 明伸、ワヒドゥザマン ムハマド、カルナン シバスンダラン、小西 裕之、細川 好孝
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-15K19561
  • [Presentation] Combined arsenic trioxide-cisplatin treatment enhances apoptosis in chronic myelogenous leukemia cell lines2016

    • Author(s)
      Md Wahiduzzaman、Akinobu Ota、Sivasundaram Karnan、Hiroyuki Konishi、Yoshitaka Hosokawa
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-15K19561
  • [Presentation] NOX1はAKTシグナルを介して口腔扁平上皮がん細胞の生存に寄与する2016

    • Author(s)
      太田 明伸、カルナン シバスンダラン、小西 裕之、風岡 宜暁、細川 好孝
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15K19561
  • [Presentation] 悪性胸膜中皮腫の早期診断の腫瘍マーカーの検討2016

    • Author(s)
      カルナン シバスンダラン、太田 明伸、ワヒドゥーズマン ムハマド、小西 裕之、細川 好孝
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-15K19561
  • 1.  シバスンダラン カルナン (30557096)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 15 results
  • 2.  Takei Norio (50523461)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 3.  Hanamura Ichiro (70440740)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 21 results
  • 4.  Hosokawa Yoshitaka (60229193)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 10 results
  • 5.  稲熊 真悟 (80410786)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  桜井 敬之 (80317825)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  NAKAO HARUHISA (60326139)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 8.  KAZAOKA YOSHIAKI (30233696)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  Ushida Takahiro (60304680)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  山田 陽一 (20345903)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  大野 隆之 (20434623)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  木全 弘治 (10022641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  鈴木 進 (70518422)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  兵頭 寿典 (40710645)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 15.  NAGAI Naoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  TSUCHIMOTO Jun
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  UEMURA Hirotsugu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  DEVELASCO Marco
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  KONISHI Hiroyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 20.  内木 綾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  高橋 智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 22.  加藤 寛之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 23.  高見 昭良
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 24.  渡辺 秀人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  杉浦 信夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  陸 美穂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  岡田 洋平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  伊藤 卓治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  大谷 隆浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  小村 理行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  津山 尚宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  坂井 晃
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  阿部 悠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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