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Kosaka Takeo  小坂 威雄

… Alternative Names

TAKEO Kosaka  小坂 威雄

KOSAKA Takeo  小坂 威雄

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Researcher Number 30445407
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1624-6676
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help 2018 – 2024: 慶應義塾大学, 医学部(信濃町), 講師
2017: 慶應義塾大学, 医学部, 助教
2017: 慶應義塾大学, 医学部, 講師
2016: 慶應義塾大学, 医学部(信濃町), 講師
2014 – 2015: 慶應義塾大学, 医学部, 講師 … More
2014: 慶応義塾大学, 医学部, 助教
2012 – 2014: 慶應義塾大学, 医学部, 助教
2010: Keio University, 医学部, 研究員
2009 – 2010: Keio University, 医学部, 研究員(非常勤) Less
Review Section/Research Field
Principal Investigator
Urology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56030:Urology-related
Except Principal Investigator
Basic Section 56030:Urology-related / Urology / Human pathology / Basic Section 52040:Radiological sciences-related
Keywords
Principal Investigator
前立腺癌 / 薬剤耐性 / シングルセル解析 / 去勢抵抗性前立腺癌 / 次世代シーケンサー / リキッドバイオプシー / 血液循環腫瘍細胞 / 神経内分泌がん / 腫瘍内不均一性 / リプログラミング … More / C4-2AT6 / アンドロゲン / 免疫逃避機構 / 代謝リプログラミング / 尿路上皮癌 / 個別化治療 / オルガノイド / 血液循環がん細胞 / セルフリーDNA / 遺伝子パネル検査 / cfDNA / 遺伝子ネットワーク / がん幹細胞 / 再プログラム化 / CRPC / リプログラミング療法 / ドラッグリポジショニング / バイオインフォマティクス / 幹細胞 / 去勢抵抗性 / 5α還元酵素 / VASH1 / 微小環境 / 血管新生 / 精子幹細胞 / iPS細胞 / エピジェネシス / 多能性幹細胞 … More
Except Principal Investigator
血管新生 / 分子標的治療 / 腎細胞癌 / 上皮間葉転換 / 尿路上皮癌 / 膀胱癌 / 免疫チェックポイント阻害剤 / 耐性 / MUC1 / 前立腺癌 / 神経内分泌前立腺癌 / 腫瘍内不均一性 / 免疫治療 / がん微小環境 / 癌化 / バソヒビン / 血管新生阻害剤 / 抗体療法 / 抗癌剤耐性 / 次世代シーケンサー / バイオマーカー / シスプラチン / 喫煙 / 予後 / 癌幹細胞 / 浸潤 / 転移 / Myc / ASCL1 / NeuroD1 / リキッドバイオプシー / 尿路上皮がん / がん免疫ゲノミクス / 多様性解析 / DN修復経路 / 薬剤スクリーニング / DNA修復経路 / タキサン系抗癌剤耐性 / DNA損傷応答 / 去勢抵抗性前立腺癌 / アンドロゲンレセプター / SWISNF / クロマチンリモデリング / ARID1A / BRG1 / SWI/SNF / がん組織不均一性 / 循環腫瘍細胞 / 膨張顕微鏡法 / 免疫微小環境 / ライトシート顕微鏡 / RNAシークエンス / 免疫療法 / シークエンス / イメージング / ドラッグ・リポジショニング / 膀胱内注入療法 / PDE5阻害薬 / 筋層非浸潤性性膀胱癌 / PDE5阻害薬 / 抗癌剤膀胱内注入 / Mitomycin C / 酸化ストレス / Tadalafil / 筋層非浸潤性膀胱癌 / 免疫応答 / 癌微小環境 / 前向き研究 / 放射線治療 / 高線量率組織内照射 / 高線量率組織内放射線照射 / 根治的前立腺全摘術 / 高リスク前立腺癌 / QOL調査 / 放射線療法 / 小線源療法 / 治療戦略 / 薬剤耐性 / 免疫 / ソラフェニブ / スニチニブ / VEGF-TKI / コンパニオン診断 / 腫瘍免疫 / 微小血管密度 / VASH1 / PD-L1 / PD-1 / プレシージョンメディスン / 微小環境 / 癌 / 免疫チェックポイント阻害薬 / リスク分類 / 治療抵抗性 / 副腎皮質 / KCNJ5 / アルドステロン産生細胞クラスター / pAATL / APCC / CYP11B2 / イオンポンプ (イオントランスポーター) / イオンチャネル / 体細胞変異 / アルドステロン産生細胞クラスター (APCC) / アルドステロン合成酵素 / 原発性アルドステロン症 / アルドステロン産生腺腫 / アルドステロン / MCP-1 / 単球 / 好中球 / ケモカイン / 耐性機序 / ユビキチン / 抗がん剤耐性 / FBXO32 / シグナル伝達 / 転写因子 / 抗癌剤 / 腎盂尿管癌 / 分子標的 / 併用効果 / 抗腫瘍効果 / PI3K/mTOR阻害剤 / アンドロゲン受容体阻害剤 / ドセタキセル抵抗性前立腺癌細胞株 / 治療耐性 / 分子標的薬 / 上皮ー間葉転換 / 上皮-間葉転換 / RANK / RANKL / 骨転移 / E-cadherin / Snail / 上皮-間葉転換 Less
  • Research Projects

    (28 results)
  • Research Products

    (198 results)
  • Co-Researchers

    (50 People)
  •  Elucidation of the molecular control mechanism of refractory prostate cancer that includes lineage plasticity and establishment of individualized treatment strategiesPrincipal Investigator

    • Principal Investigator
      小坂 威雄
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  Elucidation of tumor development mechanism by immune escape mechanism through metabolic reprogramming of anticancer drug-resistant cancerPrincipal Investigator

    • Principal Investigator
      小坂 威雄
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Keio University
  •  神経内分泌前立腺癌からダブルネガティブ前立腺癌への脱分化機構の解明

    • Principal Investigator
      安水 洋太
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  尿路上皮癌の腫瘍血管微小環境の不均一性に着目したバソヒビンによる革新的治療戦略

    • Principal Investigator
      宮崎 保匡
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  In situな尿路上皮がん免疫ゲノミクス多様性解析とリキッドバイオプシーの確立

    • Principal Investigator
      田中 伸之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  Analysis of Genomic Instability in Drug-Resistant Prostate Cancer and Novel Therapeutic Strategies Using Synthetic Lethality

    • Principal Investigator
      Hongo Hiroshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  Single-cell analysis of neuroendocrine prostate cancer to elucidate pathophysiology and establish novel treatment strategyPrincipal Investigator

    • Principal Investigator
      Kosaka Takeo
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Keio University
  •  Significance of MUC1 and chromatin remodeling factor complexes in neuroendocrine prostate cancer

    • Principal Investigator
      Yasumizu Yota
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  Integrated analysis of ITH in drug resistant prostate cancer by single cell analysisPrincipal Investigator

    • Principal Investigator
      Kosaka Takeo
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  Targeting cancer stem cells and spatial niches in kidney cancer: Unravelling intratumoral heterogeneity

    • Principal Investigator
      TANAKA NOBUYUKI
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  A prospective observational study of comparison between radical prostatectomy and radiation therapy for high risk prostate cancer

    • Principal Investigator
      Oyama Masafumi
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Saitama Medical University
  •  Establishment of new therapy targeting immune response and angiogenesis regulator vasohibin in prostate cancer

    • Principal Investigator
      Miyazaki Yasumasa
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  Drug repositioning approaches for novel intravesical treatment against bladder cancer

    • Principal Investigator
      MATSUMOTO Kazuhiro
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  Development of novel therapeutic modality by integrated analysis of immune environment of renal cell carcinoma and remodeling after inhibition of angiogenesis

    • Principal Investigator
      OYA Mototsugu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  Establishment of the novel treatment strategy against urothelial carcinoma controlling for cancer stem-like property

    • Principal Investigator
      Kikuchi Eiji
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      St. Marianna University School of Medicine
      Keio University
  •  Search for biomarkers and novel therapeutic strategies targeting heterogeneity and plasticity in prostate cancerPrincipal Investigator

    • Principal Investigator
      KOSAKA Takeo
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Keio University
  •  Study of the tumor microenvironment during progression and acquisition of treatment resistance of renal cell carcinoma

    • Principal Investigator
      Mikami Shuji
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Keio University
  •  Role of chemokine in urothelial cancer progression

    • Principal Investigator
      MIYAJIMA Akira
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Tokai University
      Keio University
  •  Ealucidation of progression from aldosterone-producing cell cluster leading to aldosterone-producing adenoma

    • Principal Investigator
      Nishimoto Koshiro
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Saitama Medical University
      Keio University
  •  Elucidation of refractory mechanism to the molecular targeted therapy for renal cell carcinoma

    • Principal Investigator
      Oya Mototsugu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Urology
    • Research Institution
      Keio University
  •  Novel anti-cancer therapeutic strategy with mTORC1/2 inhibitor against bladder cancer

    • Principal Investigator
      KIKUCHI EIJI
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Keio University
  •  Tumor microenvironment and ubiquitin system in platinum resistance urothelial carcinoma

    • Principal Investigator
      TANAKA NOBUYUKI
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Keio University
  •  New strategy of Identifying a candidate drug of reprogramming prostate cancer by targeting gene networkPrincipal Investigator

    • Principal Investigator
      KOSAKA TAKEO
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Urology
    • Research Institution
      Keio University
  •  Analysis of effect and resistance of molecular-targeted therapy in renal cell carcinoma

    • Principal Investigator
      Mikami Shuji
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Keio University
  •  New treatment strategy of refractory prostate cancer by regulation of androgen-androgen receptor axis and PI3K/Akt pathway

    • Principal Investigator
      ISHIOKA KATSURA
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Urology
    • Research Institution
      Keio University
  •  Castration resistant prostate cancer with drug resistance and tumor microenvironmentPrincipal Investigator

    • Principal Investigator
      TAKEO Kosaka
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Urology
    • Research Institution
      Keio University
  •  Microenviroment and organ specific metastases in urological cancers as tools to elucidate molecular mechanism of carcinogenesis and tumor development.

    • Principal Investigator
      OYA Mototsugu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Urology
    • Research Institution
      Keio University
  •  The prospective analysis in generation of pluripotency in primordial germ cellsPrincipal Investigator

    • Principal Investigator
      KOSAKA Takeo
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Urology
    • Research Institution
      Keio University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

  • [Book] 前立腺癌-基礎・臨床研究の最新知見2016

    • Author(s)
      小坂 威雄, 大家 基嗣 (分担執筆)
    • Publisher
      日本臨床
    • Data Source
      KAKENHI-PROJECT-26861299
  • [Journal Article] Profiling Fibroblast Growth Factor Receptor 3 Expression Based on the Immune Microenvironment in Upper Tract Urothelial Carcinoma2024

    • Author(s)
      Shigeta Keisuke、Matsumoto Kazuhiro、Kitaoka Sotaro、Omura Minami、Umeda Kota、Arita Yuki、Mikami Shuji、Fukumoto Keishiro、Yasumizu Yota、Tanaka Nobuyuki、Takeda Toshikazu、Morita Shinya、Kosaka Takeo、Mizuno Ryuichi、Hara Satoshi、Oya Mototsugu
    • Journal Title

      European Urology Oncology

      Volume: NA Issue: 6 Pages: 1338-1349

    • DOI

      10.1016/j.euo.2024.01.013

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K18344
  • [Journal Article] Vasohibin-1 Expression Can Predict Pathological Complete Remission of Advanced Bladder Cancer with Neoadjuvant Chemotherapy2024

    • Author(s)
      Omura Minami、Kosaka Takeo、Kobayashi Hiroaki、Shigeta Keisuke、Matsumoto Kazuhiro、Hara Satoshi、Kikuchi Eiji、Mikami Shuji、Saya Hideyuki、Sato Yasufumi、Oya Mototsugu
    • Journal Title

      Annals of Surgical Oncology

      Volume: 31 Issue: 5 Pages: 2951-2958

    • DOI

      10.1245/s10434-024-15009-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K18344
  • [Journal Article] IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer2023

    • Author(s)
      Shigeta Keisuke、Hasegawa Masanori、Hishiki Takako、Naito Yoshiko、Baba Yuto、Mikami Shuji、Matsumoto Kazuhiro、Mizuno Ryuichi、Miyajima Akira、Kikuchi Eiji、Saya Hideyuki、Kosaka Takeo、Oya Mototsugu
    • Journal Title

      The EMBO Journal

      Volume: 42 Issue: 4 Pages: 1-27

    • DOI

      10.15252/embj.2022110620

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-21K19579, KAKENHI-PROJECT-21K20811
  • [Journal Article] G-protein signaling of oxytocin receptor as a potential target for cabazitaxel-resistant prostate cancer2023

    • Author(s)
      Hongo Hiroshi、Kosaka Takeo、Takayama Ken-Ichi、Baba Yuto、Yasumizu Yota、Ueda Koji、Suzuki Yutaka、Inoue Satoshi、Beltran Himisha、Oya Mototsugu
    • Journal Title

      PNAS Nexus

      Volume: 3 Issue: 1 Pages: 002-002

    • DOI

      10.1093/pnasnexus/pgae002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K06408, KAKENHI-PROJECT-21K09436, KAKENHI-PROJECT-21H04829
  • [Journal Article] Prognostic role of the innate immune signature CD163 and “eat me” signal calreticulin in clear cell renal cell carcinoma2023

    • Author(s)
      Anno Tadatsugu、Tanaka Nobuyuki、Takamatsu Kimiharu、Hakozaki Kyohei、Kufukihara Ryohei、Baba Yuto、Takeda Toshikazu、Matsumoto Kazuhiro、Morita Shinya、Kosaka Takeo、Mikami Shuji、Nishihara Hiroshi、Mizuno Ryuichi、Oya Mototsugu
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: - Issue: 6 Pages: 1779-1788

    • DOI

      10.1007/s00262-023-03369-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09411, KAKENHI-PROJECT-21K19414, KAKENHI-PROJECT-22K16794, KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-23K24476
  • [Journal Article] Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy2022

    • Author(s)
      Kosaka Takeo、Hongo Hiroshi、Hayashi Hideyuki、Nakamura Kohei、Nishihara Hiroshi、Mikami Shuji、Beltran Himisha、Oya Mototsugu
    • Journal Title

      Asian Journal of Andrology

      Volume: 24 Issue: 1 Pages: 116-116

    • DOI

      10.4103/aja.aja_37_21

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K09436, KAKENHI-PROJECT-21K19579, KAKENHI-PROJECT-20K18232
  • [Journal Article] Characterizing cyclin-dependent kinase 12(CDK12)-altered aggressive prostate cancer: a twelve-case series2022

    • Author(s)
      Iwasawa Tomohiro、Kosaka Takeo、Yasumizu Yota、Hongo Hiroshi、Yanai Yoshinori、Baba Yuto、Matsumoto Kazuhiro、Nakamura Kohei、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 27 Issue: 12 Pages: 1867-1873

    • DOI

      10.1007/s10147-022-02248-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K19579
  • [Journal Article] Influence of response to prior docetaxel on sensitivity to cabazitaxel in prostate cancer patients with PTEN alterations2022

    • Author(s)
      Kamisawa Ken、Kosaka Takeo、Nakamura Kohei、Yasumizu Yota、Hongo Hiroshi、Takeda Toshikazu、Matsumoto Kazuhiro、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 9 Pages: 3161-3168

    • DOI

      10.1111/cas.15473

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K19579
  • [Journal Article] Hybridisation chain reaction-based visualisation and screening for lncRNA profiles in clear-cell renal-cell carcinoma2022

    • Author(s)
      Kufukihara Ryohei、Tanaka Nobuyuki、Takamatsu Kimiharu、Niwa Naoya、Fukumoto Keishiro、Yasumizu Yota、Takeda Toshikazu、Matsumoto Kazuhiro、Morita Shinya、Kosaka Takeo、Aimono Eriko、Nishihara Hiroshi、Mizuno Ryuichi、Oya Mototsugu
    • Journal Title

      British Journal of Cancer

      Volume: 127 Issue: 6 Pages: 1133-1141

    • DOI

      10.1038/s41416-022-01895-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09356, KAKENHI-PROJECT-21K19414, KAKENHI-PROJECT-22K16794, KAKENHI-PROJECT-23K24476
  • [Journal Article] The first Japanese case of intraductal cancer of the prostate with checkpoint kinase 2 mutation2022

    • Author(s)
      Hongo Hiroshi、Kosaka Takeo、Nakamura Kohei、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      Asian Journal of Urology

      Volume: 9 Issue: 4 Pages: 480-482

    • DOI

      10.1016/j.ajur.2022.02.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09436, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-21K19579
  • [Journal Article] Genomic analysis of aggressive ductal adenocarcinoma of the prostate2022

    • Author(s)
      Kobayashi Hiroaki、Kosaka Takeo、Nakamura Kohei、Kimura Tokuhiro、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      Cancer Medicine

      Volume: 12 Issue: 7 Pages: 8445-8451

    • DOI

      10.1002/cam4.5573

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817
  • [Journal Article] Squamous cell carcinoma of the prostate with SMARCA4 alteration in a Japanese patient2022

    • Author(s)
      Kaneko Yuta、Kosaka Takeo、Nakamura Kohei、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      IJU Case Reports

      Volume: 5 Issue: 5 Pages: 323-326

    • DOI

      10.1002/iju5.12466

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-19K07468
  • [Journal Article] A long-term survivor of metastatic neuroendocrine prostate cancer treated with multimodal therapy: genetic consideration from next-generation sequencing2021

    • Author(s)
      Hongo Hiroshi、Kosaka Takeo、Nakatsuka Seishi、Oya Mototsugu
    • Journal Title

      International Cancer Conference Journal

      Volume: - Issue: 3 Pages: 174-180

    • DOI

      10.1007/s13691-021-00482-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K22822, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K09436, KAKENHI-PROJECT-21K19579
  • [Journal Article] Prominent response to platinum‐based chemotherapy in a patient with BRCA2 mutant‐neuroendocrine prostate cancer and MDM2 amplification2021

    • Author(s)
      Daimon Tatsuaki、Kosaka Takeo、Hongo Hiroshi、Aimono Eriko、Nakamura Kohei、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      IJU Case Reports

      Volume: 4 Issue: 4 Pages: 216-219

    • DOI

      10.1002/iju5.12287

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K18232
  • [Journal Article] Discovery of a new candidate drug to overcome cabazitaxel-resistant gene signature in castration-resistant prostate cancer by in silico screening2021

    • Author(s)
      Hongo Hiroshi、Kosaka Takeo、Suzuki Yoko、Oya Mototsugu
    • Journal Title

      Prostate Cancer and Prostatic Diseases

      Volume: - Issue: 1 Pages: 59-66

    • DOI

      10.1038/s41391-021-00426-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K22822, KAKENHI-PROJECT-21K09436
  • [Journal Article] First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations2021

    • Author(s)
      Omura Minami、Kosaka Takeo、Aimono Eriko、Nakamura Kohei、Hongo Hiroshi、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      IJU Case Reports

      Volume: 5 Issue: 1 Pages: 41-44

    • DOI

      10.1002/iju5.12383

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19579, KAKENHI-PROJECT-20K18232
  • [Journal Article] Topoisomerase II alpha inhibition can overcome taxane-resistant prostate cancer through DNA repair pathways.2021

    • Author(s)
      Hongo H, Kosaka T, Suzuki Y, Mikami S, Fukada J, Oya M.
    • Journal Title

      Scientific Report

      Volume: - Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-021-01697-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K22822, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K07606, KAKENHI-PROJECT-21K09436
  • [Journal Article] CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer2021

    • Author(s)
      Yanai Yoshinori、Kosaka Takeo、Mikami Shuji、Hongo Hiroshi、Yasumizu Yota、Takeda Toshikazu、Matsumoto Kazuhiro、Miyauchi Jun、Kitano Shigehisa、Oya Mototsugu
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1-7

    • DOI

      10.1038/s41598-021-01900-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817
  • [Journal Article] A first case of ductal adenocarcinoma of the prostate having characteristics of neuroendocrine phenotype with PTEN, RB1 and TP53 alterations2021

    • Author(s)
      Kobayashi Hiroaki、Kosaka Takeo、Nakamura Kohei、Shojo Kazunori、Hongo Hiroshi、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      BMC Medical Genomics

      Volume: 14 Issue: 1 Pages: 1-4

    • DOI

      10.1186/s12920-021-01093-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19579
  • [Journal Article] Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer2021

    • Author(s)
      Takayama Ken-ichi、Kosaka Takeo、Suzuki Takashi、Hongo Hiroshi、Oya Mototsugu、Fujimura Tetsuya、Suzuki Yutaka、Inoue Satoshi
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 3766-3766

    • DOI

      10.1038/s41467-021-23974-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-20K21667, KAKENHI-PROJECT-21H04829, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K07350
  • [Journal Article] First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion2021

    • Author(s)
      Shojo Kazunori、Kosaka Takeo、Nakamura Kohei、Hongo Hiroshi、Kobayashi Hiroaki、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      IJU Case Reports

      Volume: 4 Issue: 3 Pages: 176-179

    • DOI

      10.1002/iju5.12274

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K18232
  • [Journal Article] A first Japanese case of BRCA2 and RB1 co-loss organ-confined prostate cancer successfully treated by radical prostatectomy2021

    • Author(s)
      Matsumoto Kazuhiro、Kosaka Takeo、Nakamura Kohei、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      International Cancer Conference Journal

      Volume: 10(3) Issue: 3 Pages: 170-173

    • DOI

      10.1007/s13691-021-00469-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K18232
  • [Journal Article] Significance of tumor microenvironment in acquiring resistance to vascular endothelial growth factor‐tyrosine kinase inhibitor and recent advance of systemic treatment of clear cell renal cell carcinoma2020

    • Author(s)
      Mikami Shuji、Mizuno Ryuichi、Kosaka Takeo、Tanaka Nobuyuki、Kuroda Naoto、Nagashima Yoji、Okada Yasunori、Oya Mototsugu
    • Journal Title

      Pathology International

      Volume: 70 Issue: 10 Pages: 712-723

    • DOI

      10.1111/pin.12984

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-18H02939
  • [Journal Article] Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report2020

    • Author(s)
      Hongo Hiroshi、Kosaka Takeo、Aimono Eriko、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      Diagnostic Pathology

      Volume: 15 Issue: 1 Pages: 916-919

    • DOI

      10.1186/s13000-019-0916-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Journal Article] Role of the MUC1‐C oncoprotein in the acquisition of cisplatin resistance by urothelial carcinoma2020

    • Author(s)
      Shigeta Keisuke、Hasegawa Masanori、Kikuchi Eiji、Yasumizu Yota、Kosaka Takeo、Mizuno Ryuichi、Mikami Shuji、Miyajima Akira、Kufe Donald、Oya Mototsugu
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 10 Pages: 3639-3652

    • DOI

      10.1111/cas.14574

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-18H02939, KAKENHI-PROJECT-19K18599
  • [Journal Article] CDK12 and HER2 coamplification in two urothelial carcinomas with rapid and aggressive clinical progression2020

    • Author(s)
      Yanai Yoshinori、Kosaka Takeo、Nakamura Kohei、Aimono Eriko、Matsumoto Kazuhiro、Morita Shinya、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 12 Pages: 4652-4655

    • DOI

      10.1111/cas.14672

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817
  • [Journal Article] Pulmonary metastasis secondary to abiraterone‐resistant prostate cancer with homozygous deletions of BRCA2: First Japanese case2020

    • Author(s)
      Izawa Mizuki、Kosaka Takeo、Nakamura Kohei、Oba Junna、Hishida Tomoyuki、Hongo Hiroshi、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      IJU Case Reports

      Volume: 4 Issue: 1 Pages: 14-17

    • DOI

      10.1002/iju5.12224

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817
  • [Journal Article] A first Japanese case of neuroendocrine prostate cancer accompanied by lung and brain metastasis with somatic and germline BRCA2 mutation2019

    • Author(s)
      Kosaka Takeo、Hongo Hiroshi、Aimono Eriko、Matsumoto Kazuhiro、Hayashida Tetsu、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      Pathology International

      Volume: 69 Issue: 12 Pages: 715-720

    • DOI

      10.1111/pin.12860

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Journal Article] Factors affecting renal function preservation among patients not achieving trifecta after laparoscopic partial nephrectomy for clinical T1a renal masses2019

    • Author(s)
      Takeda Toshikazu、Komatsuda Akari、Yanai Yoshinori、Tanaka Nobuyuki、Matsumoto Kazuhiro、Morita Shinya、Kosaka Takeo、Mizuno Ryuichi、Shinojima Toshiaki、Asanuma Hiroshi、Oya Mototsugu
    • Journal Title

      Asian Journal of Endoscopic Surgery

      Volume: - Issue: 4 Pages: 526-531

    • DOI

      10.1111/ases.12776

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Journal Article] Prognostic value of serum C-reactive protein level prior to second-line treatment in intermediate risk metastatic renal cell carcinoma patients2019

    • Author(s)
      Kimiharu Takamatsu, Ryuichi Mizuno, Nobuyuki Tanaka, Toshikazu Takeda, Shinya Morita, Kazuhiro Matsumoto, Takeo Kosaka, Toshiaki Shinojima, Eiji Kikuchi, Hiroshi Asanuma, Masafumi Oyama, Shuji Mikami, Mototsugu Oya
    • Journal Title

      Int J Clin Oncol

      Volume: 24 Issue: 9 Pages: 1069-1074

    • DOI

      10.1007/s10147-019-01459-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09150, KAKENHI-PROJECT-18H02939, KAKENHI-PROJECT-17K11159
  • [Journal Article] Japanese Case of Enzalutamide-Resistant Prostate Cancer Harboring a SPOP Mutation With Scattered Allelic Imbalance: Response to Platinum-Based Therapy.2019

    • Author(s)
      Watanabe K, Kosaka T, Aimono E, Hongo H, Mikami S, Nishihara H, Oya M
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: 17 Issue: 5 Pages: e897-e902

    • DOI

      10.1016/j.clgc.2019.06.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-17K11158
  • [Journal Article] Complete response with early introduction of cabazitaxel in a patient with multiple lung metastases of castration-resistant prostate cancer following the early detection of metastases using liquid biopsy: a case report2019

    • Author(s)
      Kosaka Takeo、Hongo Hiroshi、Oya Mototsugu
    • Journal Title

      BMC Cancer

      Volume: 19 Issue: 1 Pages: 5782-5784

    • DOI

      10.1186/s12885-019-5782-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Journal Article] TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells.2019

    • Author(s)
      Niwa N, Tanaka N, Hongo H, Miyazaki Y, Takamatsu K, Mizuno R, Kikuchi E, Mikami S, Kosaka T, Oya M.
    • Journal Title

      Laboratory Investigation

      Volume: 99 Issue: 11 Pages: 1702-1713

    • DOI

      10.1038/s41374-019-0285-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-18K19482, KAKENHI-PUBLICLY-18H04906, KAKENHI-PROJECT-19H03792
  • [Journal Article] Sulfasalazine could modulate the CD 44v9‐xCT system and enhance cisplatin‐induced cytotoxic effects in metastatic bladder cancer2019

    • Author(s)
      Ogihara Koichiro、Kikuchi Eiji、Okazaki Shogo、Hagiwara Masayuki、Takeda Toshikazu、Matsumoto Kazuhiro、Kosaka Takeo、Mikami Shuji、Saya Hideyuki、Oya Mototsugu
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 4 Pages: 1431-1441

    • DOI

      10.1111/cas.13960

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-16K08657, KAKENHI-PROJECT-17K16812, KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-17K11158
  • [Journal Article] Evaluation of prostate-specific antigen density in the diagnosis of prostate cancer combined with magnetic resonance imaging before biopsy in men aged 70 years and older with elevated PSA.2018

    • Author(s)
      Yanai Y, Kosaka T, Hongo H, Matsumoto K, Shinojima T, Kikuchi E, Miyajima A, Mizuno R, Mikami S, Jinzaki M, Oya M.
    • Journal Title

      Mol Clin Oncol.

      Volume: 9 Pages: 656-660

    • DOI

      10.3892/mco.2018.1725

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08657
  • [Journal Article] PKM2 under hypoxic environment causes resistance to mTOR inhibitor in human castration resistant prostate cancer2018

    • Author(s)
      Yasumizu Yota、Hongo Hiroshi、Kosaka Takeo、Mikami Shuji、Nishimoto Koshiro、Kikuchi Eiji、Oya Mototsugu
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 45 Pages: 27698-27707

    • DOI

      10.18632/oncotarget.25498

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-17K16813
  • [Journal Article] Analysis of cabazitaxel-resistant mechanism in human castration-resistant prostate cancer2018

    • Author(s)
      Hongo Hiroshi、Kosaka Takeo、Oya Mototsugu
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 9 Pages: 2937-2945

    • DOI

      10.1111/cas.13729

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-17K16813
  • [Journal Article] Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer2018

    • Author(s)
      Hagiwara Masayuki, Kikuchi Eiji, Tanaka Nobuyuki, Kosaka Takeo, Mikami Shuji, Saya Hideyuki, Oya Mototsugu
    • Journal Title

      BMC Cancer

      Volume: 18 Issue: 1

    • DOI

      10.1186/s12885-018-3988-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08657, KAKENHI-PROJECT-17K11157
  • [Journal Article] No significant impact of patient age and prior treatment profile with docetaxel on the efficacy of cabazitaxel in patient with castration-resistant prostate cancer2018

    • Author(s)
      Kosaka Takeo、Hongo Hiroshi、Watanabe Keitaro、Mizuno Ryuichi、Kikuchi Eiji、Oya Mototsugu
    • Journal Title

      Cancer Chemotherapy and Pharmacology

      Volume: 82 Issue: 6 Pages: 1061-1066

    • DOI

      10.1007/s00280-018-3698-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-17K16813
  • [Journal Article] Single-cell RNA-seq analysis reveals the platinum resistance gene COX7B and the surrogate marker CD632018

    • Author(s)
      Tanaka Nobuyuki、Katayama Shintaro、Reddy Aparna、Nishimura Kaneyasu、Niwa Naoya、Hongo Hiroshi、Ogihara Koichiro、Kosaka Takeo、Mizuno Ryuichi、Kikuchi Eiji、Mikami Shuji、Miyakawa Ayako、Arenas Ernest、Kere Juha、Oya Mototsugu、Uhl?n Per
    • Journal Title

      Cancer Medicine

      Volume: 7 Issue: 12 Pages: 6193-6204

    • DOI

      10.1002/cam4.1828

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-18K19482, KAKENHI-PUBLICLY-18H04906, KAKENHI-PROJECT-16K08657
  • [Journal Article] Prognostic Value of Baseline Serum C-Reactive Protein Level in Intermediate-Risk Group Patients With Metastatic Renal-Cell Carcinoma Treated by First-Line Vascular Endothelial Growth Factor-Targeted Therapy.2018

    • Author(s)
      Takamatsu K1, Mizuno R2, Omura M1, Morita S1, Matsumoto K1, Shinoda K1, Kosaka T1, Takeda T1, Shinojima T1, Kikuchi E1, Asanuma H1, Oyama M3, Mikami S4, Oya M1.
    • Journal Title

      Clin Genitourin Cancer

      Volume: 16(4) Issue: 4 Pages: e927-e933

    • DOI

      10.1016/j.clgc.2018.03.012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11159, KAKENHI-PROJECT-18K09150, KAKENHI-PROJECT-18H02939
  • [Journal Article] Clinical outcome of high dose rate brachytherapy with external beam radiotherapy for high-risk prostate cancer: a single institutional retrospective study2018

    • Author(s)
      Shirotake Suguru、Makino Soichi、Suzuki Kenjiro、Araki Ryuichiro、Kosaka Takeo、Nishimoto Koshiro、Oyama Masafumi、Kato Shingo
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 49 Issue: 1 Pages: 87-91

    • DOI

      10.1093/jjco/hyy174

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07642
  • [Journal Article] Vasohibin-1 as a novel microenvironmental biomarker for patient risk reclassification in low-risk prostate cancer2018

    • Author(s)
      Kobayashi Hiroaki, Kosaka Takeo, Mikami Shuji, Miyazaki Yasumasa, Matsumoto Kazuhiro, Kikuchi Eiji, Miyajima Akira, Kameyama Kaori, Sato Yasufumi, Oya Mototsugu
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 12 Pages: 10203-10210

    • DOI

      10.18632/oncotarget.23011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08657, KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-15K10609
  • [Journal Article] Prognostic significance of grade 3/4 neutropenia in Japanese prostate cancer patients treated with cabazitaxel.2018

    • Author(s)
      Kosaka T, Shinojima T, Morita S, Oya M.
    • Journal Title

      Cancer Sci.

      Volume: in press Issue: 5 Pages: 1570-1575

    • DOI

      10.1111/cas.13556

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Journal Article] Aldosterone and 18-oxocortisol coaccumulation in aldosterone-producing lesions2018

    • Author(s)
      Sugiura Yuki, Takeo Emi, Shimma Shuichi, Yokota Mai, Higashi Tatsuya, Seki Tsugio, Mizuno Yosuke, Oya Mototsugu Kosaka Takeo, Omura Masao, Nishikawa Tetsuo, Suematsu Makoto, Nishimoto Koshiro
    • Journal Title

      Hypertension

      Volume: 72 Issue: 6 Pages: 1345-1354

    • DOI

      10.1161/hypertensionaha.118.11243

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08250, KAKENHI-PROJECT-18K09205, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-18J20250, KAKENHI-PROJECT-15K10650
  • [Journal Article] Increased vasohibin-1 expression is associated with metastasis and poor prognosis of renal cell carcinoma patients.2017

    • Author(s)
      Mikami S, Oya M, Kosaka T, Mizuno R, Miyazaki Y, Sato Y, Okada Y.
    • Journal Title

      Lab Invest.

      Volume: - Issue: 7 Pages: 854-862

    • DOI

      10.1038/labinvest.2017.26

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08657, KAKENHI-PROJECT-15H04977
  • [Journal Article] Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism2017

    • Author(s)
      Nishimoto, K., Koga, M., Seki, T., Oki, K., Gomez-Sanchez, E.P., Gomez-Sanchez, C.E., Naruse, M., Sakaguchi, T., Morita, S., Kosaka, T., Oya, M., Ogishima, T., Yasuda, M., Suematsu, M., Kabe, T., Omura, M., Nishikawa, T., Mukai, K.
    • Journal Title

      Mol. Cell. Endocrinol.

      Volume: 441 Pages: 124-133

    • DOI

      10.1016/j.mce.2016.10.014

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461387, KAKENHI-PROJECT-26860707, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-15K10650
  • [Journal Article] Reactive oxygen species induction by cabazitaxel through inhibiting Sestrin-3 in castration resistant prostate cancer.2017

    • Author(s)
      prostate cancer. Kosaka T, Hongo H, Miyazaki Y, Nishimoto K, Miyajima A, Oya M.
    • Journal Title

      Oncotarget.

      Volume: 8(50) Issue: 50 Pages: 87675-87683

    • DOI

      10.18632/oncotarget.21147

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-15K10609
  • [Journal Article] Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma2017

    • Author(s)
      Daimon T, Kosaka T, Kikuchi E, Mikami S, Miyazaki Y, Hashimoto A, Hashimoto S, Mizuno R, Miyajima A, Okada Y, Sabe H, and Oya M
    • Journal Title

      Urol Oncol

      Volume: 35(9) Issue: 9 Pages: 543.e17-543.e24

    • DOI

      10.1016/j.urolonc.2017.04.008

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07151, KAKENHI-PROJECT-17K08614, KAKENHI-PROJECT-15K10609
  • [Journal Article] Somatic KCNJ5 mutation occurring early in adrenal development may cause a novel form of juvenile primary aldosteronism.2017

    • Author(s)
      Tamura A, Nishimoto K, Seki T, Matsuzawa Y, Saito J, Omura M, Gomez-Sanchez CE, Makita K, Matsui S, Moriya N, Inoue A, Nagata M, Sasano H, Nakamura Y, Yamazaki Y, Kabe Y, Mukai K, Kosaka T, Oya M, Suematsu S, Nishikawa T.
    • Journal Title

      Mol Cell Endocrinol.

      Volume: 441 Pages: 134-139

    • DOI

      10.1016/j.mce.2016.07.031

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04711, KAKENHI-PROJECT-26461387, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-15K10650
  • [Journal Article] Plasma fibrinogen level: An independent prognostic factor for disease-free survival and cancer-specific survival in patients with localized renal cell carcinoma2016

    • Author(s)
      Obata J, Tanaka N, Mizuno R, Kanao K, Mikami S, Matsumoto K, Kosaka T, Kikuchi E, Jinzaki M, Oya M
    • Journal Title

      BJU Int

      Volume: Epub ahead of print Issue: 4 Pages: 598-603

    • DOI

      10.1111/bju.13414

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04977, KAKENHI-PROJECT-26462429
  • [Journal Article] A case report: Nodule development from subcapsular aldosterone-producing cell clusters causes hyperaldosteronism2016

    • Author(s)
      Nishimoto K, Seki T, Kurihara I, Yokota K, Omura M, Nishikawa T, Shibata H, Kosaka T, Oya M, Suematsu M, Mukai K
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 101 Issue: 1 Pages: 6-9

    • DOI

      10.1210/jc.2015-3285

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10650, KAKENHI-PROJECT-26461387, KAKENHI-PROJECT-25461254, KAKENHI-PROJECT-25461397
  • [Journal Article] Human adrenocortical remodeling leading to aldosterone-producing cell cluster generation2016

    • Author(s)
      Nishimoto, K., Seki, T., Hayashi, Y., Mikami, S., Al-Eyd, G., Nakagawa, K., Morita, S., Kosaka, T., Oya, M., Mitani, F., Suematsu, M., Kabe, T., Mukai, K.
    • Journal Title

      Int. J. Endocrinol.

      Volume: 2016 Pages: 7834356-7834356

    • DOI

      10.1155/2016/7834356

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461387, KAKENHI-PROJECT-15K10650
  • [Journal Article] Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.2016

    • Author(s)
      Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhl P, Suematsu M, Oya M.
    • Journal Title

      JCI Insight

      Volume: 1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10609
  • [Journal Article] Relationship between increased expression of the Axl/Gas6 signal cascade and prognosis of patients with upper tract urothelial carcinoma.2016

    • Author(s)
      Hattori S, Kikuchi E, Kosaka T, Miyazaki Y, Tanaka N, Miyajima A, Mikami S, Oya M
    • Journal Title

      Ann Surg Oncol

      Volume: 23 Issue: 2 Pages: 663-670

    • DOI

      10.1245/s10434-015-4848-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462428, KAKENHI-PROJECT-26861296
  • [Journal Article] Acquired platinum resistance involves epithelial-to-mesenchymal transition through ubiquitin ligase FBXO32 dysregulation2016

    • Author(s)
      Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhlen P, Suematsu M, Oya M
    • Journal Title

      JCI insight

      Volume: 1 Issue: 18

    • DOI

      10.1172/jci.insight.83654

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04723, KAKENHI-PROJECT-26293057, KAKENHI-PROJECT-26462429, KAKENHI-PROJECT-15K15057, KAKENHI-PROJECT-26670163, KAKENHI-PROJECT-15K20110
  • [Journal Article] Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.2016

    • Author(s)
      Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhlen P, Suematsu M, Oya M.
    • Journal Title

      JCI Insight

      Volume: 1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08657
  • [Journal Article] High Absolute Monocyte Count Predicts Poor Clinical Outcome in Patients with Castration-Resistant Prostate Cancer Treated with Docetaxel Chemotherapy.2016

    • Author(s)
      Shigeta K, Kosaka T, Kitano S, Yasumizu Y, Miyazaki Y, Mizuno R, Shinojima T, Kikuchi E, Miyajima A, Tanoguchi H, Hasegawa S, Oya M.
    • Journal Title

      Annals of Surgical Oncology

      Volume: 23(12) Issue: 12 Pages: 4115-4122

    • DOI

      10.1245/s10434-016-5354-5

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460981, KAKENHI-PROJECT-15K10609
  • [Journal Article] Should We Try Antiandrogen Withdrawal in Castration-Resistant Prostate Cancer Patients? Insights From a Retrospective Study.2016

    • Author(s)
      Hongo H, Kosaka T, Mizuno R, Ezaki T, Matsumoto K, Morita S, Shinoda K, Shinojima T, Kikuchi E, Miyajima A, Oya M.
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: Epub ahead of print Issue: 6 Pages: e569-e573

    • DOI

      10.1016/j.clgc.2016.02.014

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K20109, KAKENHI-PROJECT-26861299, KAKENHI-PROJECT-16K20161
  • [Journal Article] The prognostic significance of OCT4 expression in patients with prostate cancer. Human Pathology 2016 in press2016

    • Author(s)
      Kosaka T, Mikami S, Yoshimine S, Miyazaki Y, Daimin T, Kikuchi E, Miyajima A, Oya M.
    • Journal Title

      Human Pathology 2016 in press

      Volume: in press Pages: 1-8

    • DOI

      10.1016/j.humpath.2015.12.008

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26861299
  • [Journal Article] Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer.2015

    • Author(s)
      Y. Ito, E. Kikuchi, N. Tanaka, T. Kosaki, E. Suzuki, R. Mizuno, T. Shinojima, A. Miyajima, K. Umezawa and M. Oya
    • Journal Title

      BMC Cancer

      Volume: 15 Issue: 1 Pages: 324-324

    • DOI

      10.1186/s12885-015-1315-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-26462429, KAKENHI-PROJECT-26750362
  • [Journal Article] Impact of Combined Use of Blood-based Inflammatory Markers on Patients with Upper Tract Urothelial Carcinoma Following Radical Nephroureterectomy: Proposal of a Cumulative Marker Score as a Novel Predictive Tool for Prognosis2015

    • Author(s)
      Nobuyuki Tanaka, Eiji Kikuchi, Kent Kanao, Kazuhiro Matsumoto, Suguru Shirotake, Yasumasa Miyazaki, Hiroaki Kobayashi, Gou Kaneko, Masayuki Hagiwara, Hiroki Ide, Jun Obata, Katsura Hoshino, Nozomi Hayakawa, Takeo Kosaka, Satoshi Hara, Ken Nakagawa, Masahiro Jinzaki, Mototsugu Oya
    • Journal Title

      European Urology Focus

      Volume: 1 Issue: 1 Pages: 54-63

    • DOI

      10.1016/j.euf.2015.02.001

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462429
  • [Journal Article] Renin-angiotensin system blockade: Its contribution and controversy.2015

    • Author(s)
      Miyajima A, Kosaka T, Kikuchi E, Oya M.
    • Journal Title

      Int J Urol

      Volume: 22 Issue: 8 Pages: 721-730

    • DOI

      10.1111/iju.12827

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10609
  • [Journal Article] Prognostic Impact of Renin-Angiotensin System Blockade on Renal Cell Carcinoma After Surgery.2015

    • Author(s)
      Miyajima A, Yazawa S, Kosaka T, Tanaka N, Shirotake S, Mizuno R, Kikuchi E, Oya M.
    • Journal Title

      Ann Surg Oncol

      Volume: 22 Issue: 11 Pages: 3751-3759

    • DOI

      10.1245/s10434-015-4436-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10609, KAKENHI-PROJECT-15H04977
  • [Journal Article] Efficacy of treatment with a GnRH antagonist in prostate cancer patients previously treated with a GnRH agonist.2015

    • Author(s)
      Ezaki T, Kosaka T, Mizuno R, Shinojima T, Kikuchi E, Miyajima A, Oya M.
    • Journal Title

      Cancer Chemother Pharmacol. 2015 Aug;76(2):301-6.

      Volume: Aug;76(2): Issue: 2 Pages: 301-6

    • DOI

      10.1007/s00280-015-2798-4

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26861299
  • [Journal Article] アルドステロン合成酵素の免疫組織化学による新しい副腎組織病理学2015

    • Author(s)
      西本 紘嗣郎、北村 陽典、中川 健、関 次男、小坂 威雄、大家 基嗣、向井 邦晃
    • Journal Title

      日本内分泌・甲状腺外科学会雑誌

      Volume: 32 Pages: 230-233

    • NAID

      130005133176

    • Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Journal Article] Identification of drug candidate against prostate cancer from the aspect of somatic cell reprogramming.2014

    • Author(s)
      Kosaka T, Nagamatsu G, Saito S, Oya M, Suda T, Horimoto K
    • Journal Title

      Cancer Sci

      Volume: 104 Issue: 8 Pages: 1017-1026

    • DOI

      10.1111/cas.12183

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130004, KAKENHI-PROJECT-23618011, KAKENHI-PUBLICLY-24116522, KAKENHI-PROJECT-24890230
  • [Journal Article] Prognostic value of preoperative multiparametric magnetic resonance imaging (MRI) for predicting biochemical recurrence after radical prostatectomy2014

    • Author(s)
      Hattori S, Kosaka T, Mizuno R, Kanao K, Miyajima A, Yasumizu Y, Yazawa S, Nagata H, Kikuchi E, Mikami S, Jinzaki M, Nakagawa K, Tanimoto A, Oya M
    • Journal Title

      BJU Int

      Volume: 113(5) Issue: 5 Pages: 741-7

    • DOI

      10.1111/bju.12329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Journal Article] A Multi-Institutional Validation of the Prognostic Value of the Neutrophil-to-Lymphocyte Ratio for Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy.2014

    • Author(s)
      Tanaka N, Kikuchi E, Kanao K, Matsumoto K, Shirotake S, Miyazaki Y, Kobayashi H, Kaneko G, Hagiwara M, Ide H, Obata J, Hoshino K, Hayakawa N, Kosaka T, Hara S, Oyama M, Momma T, Nakajima Y, Jinzaki M, Oya M
    • Journal Title

      Ann Surg Oncol

      Volume: 21(12) Issue: 12 Pages: 4041-8

    • DOI

      10.1245/s10434-014-3830-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390374, KAKENHI-PROJECT-26462429
  • [Journal Article] Dual PI3K/mTOR inhibitor NVP-BEZ235 sensitizes docetaxel in castration resistant prostate cancer2014

    • Author(s)
      Yasumizu Y, Miyajima A, Kosaka T, Miyazaki Y, Kikuchi E, Oya M
    • Journal Title

      J Urol

      Volume: 191(1) Issue: 1 Pages: 227-34

    • DOI

      10.1016/j.juro.2013.07.101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Journal Article] Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas.2014

    • Author(s)
      Mikami S, Mizuno R, Kosaka T, Saya H, Oya M and Okada Y
    • Journal Title

      Int J Cancer

      Volume: 136 Issue: 7 Pages: 1504-1514

    • DOI

      10.1002/ijc.29137

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390374, KAKENHI-PROJECT-25460422
  • [Journal Article] Invasion and metastasis of renal cell carcinoma2014

    • Author(s)
      Mikami S, Oya M, Mizuno R, Kosaka T, Katsube K, Okada Y.
    • Journal Title

      Medical Molecular Morphology

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460422
  • [Journal Article] Activation of aryl hydrocarbon receptor promotes invasion of clear cell renal cell carcinoma and is associated with poor prognosis and cigarette smoke.2014

    • Author(s)
      Ishida M, Mikami S, Shinojima T, Kosaka T, Mizuno R, Kikuchi E, Miyajima A, Okada Y, Oya M
    • Journal Title

      Int J Cancer

      Volume: Epub ahead of print Issue: 2 Pages: 299-310

    • DOI

      10.1002/ijc.29398

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390374, KAKENHI-PROJECT-15H04977
  • [Journal Article] Invasion and metastasis of renal cell carcinoma.2014

    • Author(s)
      Mikami S, Oya M, Mizuno R, Kosaka T, Katsube KI, Okada Y.
    • Journal Title

      Med Mol Morphol.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Journal Article] Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelialcarcinoma.2013

    • Author(s)
      Shunsuke Yoshimine, Eiji Kikuchi, Takeo Kosaka, Shuji Mikami, Akira Miyajima, Yasunori Okada, Mototsugu Oya.
    • Journal Title

      British Journal of Cancer (2013)

      Volume: 108 Issue: 11 Pages: 1-9

    • DOI

      10.1038/bjc.2013.216

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791784, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24890230
  • [Journal Article] Human castrationresistant prostate cancer rather prefer to decreased 5α-reductase activity.2013

    • Author(s)
      Kosaka T, Miyajima A, Nagata H, Maeda T, Kikuchi E, Oya M.
    • Journal Title

      Sci Rep

      Volume: 3 Issue: 1 Pages: 1268-1268

    • DOI

      10.1038/srep01268

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591777, KAKENHI-PROJECT-24890230
  • [Journal Article] The prognostic significance of vasohibin-1 expression in patients with prostate cancer.2013

    • Author(s)
      Kosaka T, Miyazaki Y, Miyajima A, Mikami S, Hayashi Y, Tanaka N, Nagata H, Kikuchi E, Nakagawa K, Okada Y, Sato Y, Oya M
    • Journal Title

      Br J Cancer.

      Volume: 108 Issue: 10 Pages: 2123-2129

    • DOI

      10.1038/bjc.2013.169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591777, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24890230
  • [Journal Article] Invasion and metastasis of renal cell carcinoma2013

    • Author(s)
      Mikami S, Oya M, Mizuno R, Kosaka T, Katsube KI, Okada Y
    • Journal Title

      Med Mol Morphol

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Journal Article] Bisebromoamide, an extract from Lyngbya species, induces apoptosis through ERK and mTOR inhibitions in renal cancer cells2013

    • Author(s)
      K. Suzuki, R. Mizuno, K. Suenaga, T. Teruya, N. Tanaka, T. Kosaka, M. Oya
    • Journal Title

      Cancer Medicine

      Volume: 2 Issue: 1 Pages: 32-39

    • DOI

      10.1002/cam4.53

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21221009, KAKENHI-PROJECT-24390374, KAKENHI-PROJECT-24890230
  • [Journal Article] Patient characteristics and outcomes in metastatic upper tract urothelial carcinoma after radical nephroureterectomy: the experience of Japanese multi-institutions2013

    • Author(s)
      Nobuyuki Tanaka, Eiji Kikuchi, Kent Kanao, Kazuhiro Matsumoto, Hiroaki Kobayashi, Yasumasa Miyazaki, Hiroki Ide, Jun Obata, Katsura Hoshino, Suguru Shirotake, Nozomi Hayakawa, Takeo Kosaka, Akira Miyajima, Tetsuo Momma, Ken Nakagawa, Shintaro Hasegawa, Yosuke Nakajima, Mototsugu Oya
    • Journal Title

      British Journal of Urology

      Volume: 112 Issue: 2 Pages: 741-747

    • DOI

      10.1111/bju.12133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791671, KAKENHI-PROJECT-24890230
  • [Journal Article] The prognostic significance of vasohibin-1 expression in patients with prostate cancer2013

    • Author(s)
      Takeo Kosaka
    • Journal Title

      Br J Cancer

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Journal Article] Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells.2011

    • Author(s)
      Taisuke Kinoshita, Go Nagamatsu, Takeo Kosaka, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 407(2)

      Pages: 321-326

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Journal Article] A Germ Cell-specific Gene, Prmt5, Works in Somatic Cell Reprogramming.2011

    • Author(s)
      Go Nagamatsu, Takeo Kosaka, et al.
    • Journal Title

      The Journal of Biological Chemistry. 286(12)

      Pages: 321-326

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Journal Article] A Germ Cell-specific Gene, Prmt5, Works in Somatic Cell Reprogramming2011

    • Author(s)
      Go Nagamatsu, Takeo Kosaka, et al
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286(12) Pages: 10641-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Journal Article] Cis-dichlorodiammineplatinum upregulates angiotensin II type 1 receptors through reactive oxygen species generation and enhances VEGF production in bladder cancer.2010

    • Author(s)
      Tanaka N, Miyajima A, Kosaka T, Shirotake S, Hasegawa M, Kikuchi E, Oya M.
    • Journal Title

      Mol Cancer Ther

      Volume: 9(11) Pages: 2982-2992

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390445
  • [Journal Article] Expression of Snail in upper urinary tract urothelial carcinoma : Prognostic significance and implications for tumor invasion.2010

    • Author(s)
      Kosaka T, Kikuchi E, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M
    • Journal Title

      Clin Cancer Res

      Volume: 16(23) Pages: 5814-5823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390445
  • [Journal Article] Activation of the Aryl hydrocarbon receptor pathway enhances cancer cell invasion by up-regulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer.2010

    • Author(s)
      Ishida M, Mikami S, Kikuchi E, Kosaka T, Miyajima A, Nakagawa K, Mukai M, Okada Y, Oya M
    • Journal Title

      Carcinogenesis

      Volume: 31(2) Pages: 287-295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390445
  • [Journal Article] Ets-1 and hypoxia inducible factor-lalpha inhibition by angiotensin II type-1 receptoe blockade in hormone-refractory prostate cancer2010

    • Author(s)
      Kosaka T, et al
    • Journal Title

      Prostate 70(2)

      Pages: 162-169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390445
  • [Presentation] がんゲノム医療の臨床(腎がん/尿路上皮がん/前立腺がん)2023

    • Author(s)
      小坂 威雄
    • Organizer
      クリニカルバイオバンク学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03817
  • [Presentation] バイオインフォマティクスを用いたカバジタキセル耐性前立腺癌リプログラミング薬剤のスクリーニング2022

    • Author(s)
      本郷 周, 小坂 威雄, 安水 洋太, 田中 伸之, 武田 利和, 森田 伸也, 松本 一宏, 水野 隆一, 大家 基嗣
    • Organizer
      前立腺シンポジウム 2022年
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03817
  • [Presentation] ゲノム医療の臨床(腎がん 尿路上皮がん 前立腺がん)2022

    • Author(s)
      小坂 威雄
    • Organizer
      クリニカルバイオバンク学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19579
  • [Presentation] 「Think different in mCSPC treatment strategies!」 前立腺癌の臨床的・生物学的特徴から考えるmHNPC転移性前立腺癌に対する個別化医療2022

    • Author(s)
      小坂 威雄
    • Organizer
      第87回日本泌尿器科学会東部総会 シンポジウム1
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03817
  • [Presentation] 前立腺がん細胞の低酸素環境における細胞遊走-増殖ダイコトミーに関わるO-結合型糖鎖の解析2022

    • Author(s)
      山本 大樹, 小坂 威雄, 大家 基嗣, 佐藤 智典
    • Organizer
      第81回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-21K19579
  • [Presentation] バイオインフォマティクスを用いたカバジタキセル耐性前立腺癌リプログラミング薬剤のスクリーニング2022

    • Author(s)
      本郷 周, 小坂 威雄, 安水 洋太, 田中 伸之, 武田 利和, 森田 伸也, 松本 一宏, 水野 隆一, 大家 基嗣
    • Organizer
      前立腺シンポジウム 2022年
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19579
  • [Presentation] 前立腺がん細胞の低酸素環境における細胞遊走-増殖ダイコトミーに関わるO-結合型糖鎖の解析2022

    • Author(s)
      山本 大樹, 小坂 威雄, 大家 基嗣, 佐藤 智典
    • Organizer
      第81回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-20H03817
  • [Presentation] シンポジウム1Think different in mCSPC treatment strategies前立腺癌の臨床的生物学的特徴から考えるmHNPC転移性前立腺癌に対する個別化医療2022

    • Author(s)
      小坂 威雄
    • Organizer
      第87回日本泌尿器科学会東部総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19579
  • [Presentation] HBOC診療の課題とこれから これからの遺伝性乳癌卵巣癌(HBOC)診療体制を再考する 慶應HBOCセンターの取り組み2022

    • Author(s)
      小林 佑介, 増田 健太, 関 朋子, 小坂 威雄, 北郷 実, 小野 伊久美, 三須 久美子, 中村 康平, 内田 明花, 舩越 建, 竹内 麻理, 小崎 健次郎, 青木 大輔
    • Organizer
      第60回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03817
  • [Presentation] 若手臨床医が基礎研究に携わる意義と方法2021

    • Author(s)
      大家基嗣、小坂威雄
    • Organizer
      第80回 日本癌学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19579
  • [Presentation] もう知らないとは言わせないHBOC 前立腺癌2021

    • Author(s)
      小坂威雄
    • Organizer
      第109回 日本泌尿器科学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03817
  • [Presentation] 進行性去勢感受性前立腺癌の治療戦略:ドセタキセル2021

    • Author(s)
      小坂威雄
    • Organizer
      第109回 日本泌尿器科学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03817
  • [Presentation] 前立腺神経内分泌がんにおける血中循環腫瘍細胞のシングルセル解析と空間的遺伝子発現解析システムを統合した腫瘍内不均一性の解明と革新的新規治療戦略の確立2021

    • Author(s)
      小坂 威雄
    • Organizer
      第109回 日本泌尿器科学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19579
  • [Presentation] 前立腺癌におけるBRCA1/2遺伝学的検査と遺伝カウンセリング 遺伝性乳癌卵巣癌(HBOC)診療ガイドライン2021と前立腺癌2021

    • Author(s)
      小坂 威雄
    • Organizer
      第109回 日本泌尿器科学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19579
  • [Presentation] Single-cell RNA-seq analysis of intra-tumor heterogeneity dynamics reveals the novel platinum resistance gene COX7B in patients with urinary bladder cancer2020

    • Author(s)
      田中伸之、丹羽直也、 本郷周、安水洋太、武田利和、松本一宏、森田伸也、小坂威雄、水野隆一、浅沼宏、Per Uhlen、大家基嗣
    • Organizer
      第108回日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-19H03792
  • [Presentation] 腫瘍免疫学的分類(Immuno-clustering)による腎細胞癌の新しいサブクラス分類と臨床的有用性2020

    • Author(s)
      髙松 公晴, 田中 伸之, 三上 修治, 箱崎 恭平, 髙橋 遼平, 武田 利和, 森田 伸也, 松本 一宏, 小坂 威雄, 水野 隆一, 浅沼 宏, 垣見 和宏, 大家 基嗣
    • Organizer
      第108回日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Presentation] 進行性去勢感受性前立腺癌の治療戦略:ドセタキセル2020

    • Author(s)
      小坂威雄、大家基嗣
    • Organizer
      第58回日本癌治療学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03817
  • [Presentation] 転移性腎癌における転移巣完全切除の臨床的効果2020

    • Author(s)
      高松 公晴, 水野 隆一, 安水 洋太, 田中 伸之, 武田 利和, 森田 伸也, 松本 一宏, 小坂 威雄, 浅沼 宏, 大東 貴志, 大家 基嗣
    • Organizer
      第58回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Presentation] mCRPCの未来予想図:タキサン系抗がん剤の位置づけを再考する2020

    • Author(s)
      小坂威雄
    • Organizer
      第6回日本泌尿器腫瘍学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03817
  • [Presentation] 進行性腎細胞癌favorableリスク群における予後因子の検討2020

    • Author(s)
      水野 隆一, 高松 公晴, 安水 洋太, 田中 伸之, 森田 伸也, 松本 一宏, 武田 利和, 小坂 威雄, 浅沼 宏, 大家 基嗣
    • Organizer
      第58回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Presentation] 淡明細胞型腎細胞癌におけるAXL発現の腫瘍内不均一性と予後の検討2020

    • Author(s)
      箱崎 恭平, 田中 伸之, 高松 公晴, 安水 洋太, 武田 利和, 松本 一宏, 森田 伸也, 小坂 威雄, 水野 隆一, 浅沼 宏, 大家 基嗣
    • Organizer
      第58回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Presentation] 透析患者に発生する腎細胞癌のOmics解析と腫瘍免疫微小環境の統合的理解2020

    • Author(s)
      高橋 遼平, 田中 伸之, 宮 冬樹, 鎌谷 高志, 武田 利和, 松本 一宏, 森田 伸也, 小坂 威雄, 水野 隆一, 三上 修治, 垣見 和宏, 角田 達彦, 大家 基嗣
    • Organizer
      第108回日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Presentation] 淡明型腎細胞癌における三次リンパ様構造(TLS)の臨床病理学的検討2020

    • Author(s)
      桝田 司, 田中 伸之, 箱崎 恭平, 高松 公晴, 安水 洋太, 武田 利和, 松本 一宏, 森田 伸也, 小坂 威雄, 水野 隆一, 浅沼 宏, 三上 修治, 大家 基嗣
    • Organizer
      第58回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Presentation] タキサン系抗癌剤耐性前立腺癌に対するトポイソメラーゼ阻害剤の有用性2019

    • Author(s)
      本郷, 周 小坂, 威雄 安水, 洋太 宮崎, 保匡 田中, 伸之 武田, 利和 松本, 一宏 森田, 伸也 水野, 隆一 大家, 基嗣
    • Organizer
      57回日本癌治療学会
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] Innovative approach for cancer by advanced microscopy Visualizing Intratumoral Heterogeneity by 3D Light Sheet Microscopy: Cell-by-Cell Protein/RNA Analysis in Intact Tumors2019

    • Author(s)
      田中, 伸之 三上, 修治 小坂, 威雄 水野, 隆一 大家, 基嗣
    • Organizer
      78回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] 癌幹細胞を標的としたスルファサラジン膀胱内注入治療の効果2019

    • Author(s)
      荻原広一郎、菊地栄次、田中伸之、小坂威雄、佐谷秀行、大家基嗣
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K11157
  • [Presentation] 3次元ライトシート顕微鏡による腫瘍内不均一性の可視化:スライドフリーな1細胞レ ベルのタンパク/RNA発現解析2019

    • Author(s)
      田中 伸之、三上 修治、小坂 威雄、水野 隆一、大家 基嗣
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19H03792
  • [Presentation] 前立腺癌薬物治療のパラダイムシフト バイオマーカーのパラダイムシフト Precision medicineに向けて2019

    • Author(s)
      小坂, 威雄 大家, 基嗣
    • Organizer
      107回日本泌尿器科学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] 3次元ライトシート顕微鏡を用いた次世代泌尿器癌イメージング:腫瘍内不均一 性の可視化2019

    • Author(s)
      田中 伸之、三上 修治、桝田 司、武田 利和、松本 一宏、森田 伸也、小坂 威雄、浅沼 宏、水野 隆一、大家 基嗣
    • Organizer
      第57回 日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03792
  • [Presentation] ゲムシタビン耐性膀胱癌は癌蛋白MUC1Cを介して、シスプラチンへの交叉耐性を獲得する2019

    • Author(s)
      茂田, 啓介 菊地, 栄次 長谷川, 政徳 荻原, 広一郎 小坂, 威雄 水野, 隆一 宮嶋, 哲 大家, 基嗣
    • Organizer
      107回日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] Prognostic value of serum C-reactive protein level prior to second-line treatment in intermediate risk metastatic renal cell carcinoma patients.2019

    • Author(s)
      Takamatsu K, Mizuno R, Hayakawa N, Kikuchi E, Kosaka T, Oya M
    • Organizer
      ASCO Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Presentation] G2/M期制御因子を標的としたカバジタキセル耐性前立腺癌克服薬剤のIn silico screening2019

    • Author(s)
      本郷, 周 小坂, 威雄 楊井, 祥典 安水, 洋太 宮崎, 保匡 水野, 隆一 菊地, 栄次 大家, 基嗣
    • Organizer
      107回日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] Efficacy of systemic therapy for metastatic renal cell carcinoma in patients over 75 years of age.2019

    • Author(s)
      Mizuno R, Takamatsu K, Hayakawa N, Kosaka T, Tanaka N, Oya M
    • Organizer
      ASCO Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Presentation] Network Medicine to Overcome Drug Resistance in CRPC or NEPC: Drug Efficacy Reprogramming2018

    • Author(s)
      小坂威雄
    • Organizer
      第106回日本泌尿器科学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] Constitutive activation of mTOR pathways in renal cell carcinoma arising in dialyzed patients.2018

    • Author(s)
      Mizuno R, Mikami S, Takamatsu K, Hayakawa N, Kosaka T, Kikuchi E, Oya M
    • Organizer
      ASCO Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Presentation] In silico screening using RNA-seq data sets of Neuroendocrine prostate cancer has identified candidate drugs for reprogramming NEPC-specific signatures2018

    • Author(s)
      Kosaka T, Hongo H, Mikami S, Matsumoto K, Kikuchi E, Oya M:
    • Organizer
      AUA Annual Meeting San Francisco: 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] The clinical impact of serum C-reactive protein levels in metastatic renal-cell carcinoma patients treated by second-line molecular targeted therapies.2018

    • Author(s)
      Takamatsu K, Mizuno R, Hayakawa N, Kosaka T, Kikuchi E, Mikami S, Oya M
    • Organizer
      ASCO Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02939
  • [Presentation] CRPC に対する抗がん化学療法の現況と課題:リアルワールドデータから考察する2018

    • Author(s)
      小坂威雄
    • Organizer
      日本泌尿器腫瘍学会第4回学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] 前立腺癌のリキッドバイオプシー(血液循環腫瘍細胞:CTC)の現状と課題2018

    • Author(s)
      小坂威雄、本郷周、大家基嗣
    • Organizer
      第56回日本癌治療学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] Imaging mass spectrometry co-accumlation and 18-oxocortisol with CYP11B2 in pre-adenomatous states of primary aldosteronism2018

    • Author(s)
      Yuki Sugiura, Emi Takeo, Shuichi Shimma, Mai Yokota, Tatsuya Higashi, Tsugio Seki, Mototsugu Oya, Takeo Kosaka, Tetsuo Nishikawa, Koshiro Nishimoto, Motoko Suematsu
    • Organizer
      AUA2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Presentation] Aldosterone specific visualization in primary aldosteronism using imaging mass spectrometry2018

    • Author(s)
      Shuichi Shimma, Emi Takeo, Koshiro Nishimoto, Eiichiro Fukusaki, Yuki Sugiura
    • Organizer
      XXII International Mass Spectrometry Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Presentation] MALDIイメージングから視えてきたアルドステロン(aldo)産生病変の進展様式2018

    • Author(s)
      西本 紘嗣郎, 杉浦 悠毅, 竹尾 映美, 新間 秀一, 東 達也, 西川 哲男, 小坂 威雄, 大家 基嗣, 末松 誠
    • Organizer
      第106回日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Presentation] Roles of topoisomerase inhibitors and cisplatin for CRPC in the post-cabazitaxel setting2018

    • Author(s)
      Kosaka T, Hongo H, Yasumizu Y, Miyazaki Y, Kikuchi E, Oya M
    • Organizer
      AUA Annual Meeting San Francisco: 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] 転移性腎細胞癌に対するニボルマブの効果予測因子の検討2018

    • Author(s)
      高松 公晴, 水野 隆一, 田中 伸之, 武田 利和, 森田 伸也, 松本 一宏, 小坂 威雄, 篠島 利明, 菊地 栄次, 浅沼 宏, 三上 修治, 大家 基嗣
    • Organizer
      第56回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08657
  • [Presentation] 上部尿路上皮癌におけるPD-1発現の臨床的検討2017

    • Author(s)
      弓削 和之, 菊地 栄次, 早川 望, 福本 桂資郎, 小坂 威雄, 三上 修治, 宮嶋 哲, 飯沼 誠一, 大家 基嗣
    • Organizer
      日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-16K08657
  • [Presentation] 尿路上皮癌細胞における糖尿病治療薬メトホルミンを用いた CD44v 制御2017

    • Author(s)
      萩原正幸、菊地栄次、小坂威雄、宮嶋哲、中川健、佐谷秀行
    • Organizer
      第105回日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-17K11157
  • [Presentation] 前立腺癌における予後因子としてのバソヒビン2発現の検討2017

    • Author(s)
      宮崎 保匡, 小坂 威雄, 三上 修治, 安水 洋太, 田中 伸之, 菊地 栄次, 佐藤 靖史, 大家 基嗣
    • Organizer
      日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-16K08657
  • [Presentation] 有効性と安全性の狭間から見えてきたカバジタキセル使用の実際2017

    • Author(s)
      小坂威雄、篠島利明、森田伸也、大家基嗣
    • Organizer
      第82回日本泌尿器科学会東部総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] 前立腺癌におけるLiquid Biopsyの現状と課題2017

    • Author(s)
      小坂威雄、大家基嗣
    • Organizer
      第82回日本泌尿器科学会東部総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] ニボルマブ関連間質性肺炎に対してステロイドが有効であった転移性腎細胞癌の1例2017

    • Author(s)
      岩佐俊、水野隆一、寺西悠、森田伸也、篠田和伸、小坂威雄、篠島利明、菊地栄次、浅沼宏、秋田大宇、陣崎雅弘、額賀重成、大家基嗣
    • Organizer
      第82回日本泌尿器科学会東部総会
    • Data Source
      KAKENHI-PROJECT-15H04977
  • [Presentation] BCL6を標的としたエンザルタミド耐性去勢抵抗性前立腺癌克服戦略2017

    • Author(s)
      本郷周、小坂威雄、宮崎保匡、菊地栄次、大家基嗣
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] Visualization of aldosteronerelated steroids on adrenal frozen sections.2017

    • Author(s)
      Nishimoto K, Higashi T, Nishikawa T, Seki T, Oyama M, Kosaka T, Oya M, Suematsu M, Sugiura Y.
    • Organizer
      European Urology Association 2017
    • Place of Presentation
      London、イギリス
    • Year and Date
      2017-03-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Presentation] 血管新生阻害薬に対して初期耐性を示した進行性腎細胞癌症例の特徴2017

    • Author(s)
      篠島利明、水野隆一、松本一宏、森田伸也、篠田和伸、小坂威雄、菊地栄次、浅沼宏、宮嶋哲、大家基嗣
    • Organizer
      第105回日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-15H04977
  • [Presentation] 上皮間葉移行に着目したカバジタキセル耐性去勢抵抗性前立腺癌克服戦略2017

    • Author(s)
      本郷周、小坂威雄、菊地栄次、宮嶋哲、大家基嗣
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K11158
  • [Presentation] 当院における腹腔鏡下副腎部分切除術の術式確立の試み2017

    • Author(s)
      勝井政博、宮嶋哲、森田伸也、松本一宏、篠田和伸、小坂威雄、水野隆一、篠島利明、菊地栄次、浅沼宏、大家基嗣
    • Organizer
      第105回日本泌尿器科学会総会
    • Data Source
      KAKENHI-PROJECT-15H04977
  • [Presentation] 前立腺癌のがん幹細胞性遺伝子ネットワークを標的とした薬剤耐性克服を目指す新規治療戦略2016

    • Author(s)
      小坂威雄
    • Organizer
      第11回TRワークシップ
    • Place of Presentation
      都市センターホテル(東京都千代田区)
    • Year and Date
      2016-01-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-26861299
  • [Presentation] 尿路上皮癌細胞におけるニコチンのPI3K/Akt/mTOR経路を介した抗癌剤耐性獲得に関わる基礎的研究2016

    • Author(s)
      弓削和之、菊地栄次、荻原広一郎、福本桂資郎、萩原正幸、安水洋太、田中伸之、松本一宏、小坂威雄、宮嶋哲、大家基嗣
    • Organizer
      第25回泌尿器科分子・細胞研究会
    • Place of Presentation
      ハイアット リージェンシー 大阪(大阪府大阪市)
    • Year and Date
      2016-02-26
    • Data Source
      KAKENHI-PROJECT-26462428
  • [Presentation] Nicotine induces aggressiveness and acquiring chemoresistance in bladder cancer cells2016

    • Author(s)
      Yuge K, Kikuchi E, Ogihara K, Fukumoto K, Hagiwara M, Yasumizu Y, Tanaka N, Matsumoto K, Kosaka T, Miyajima A, Iinuma S, Oya M
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-04-23
    • Data Source
      KAKENHI-PROJECT-26462428
  • [Presentation] アルドステロン産生細胞クラスターからアルドステロン産生腺腫への移行を示唆する新規病変の同定とその体細胞遺伝子変異解析2016

    • Author(s)
      西本紘嗣郎、関 次男、栗原 勲、横田 健一、大村 昌夫、西川 哲男、柴田 洋孝、小坂 威雄、大家 基嗣、末松 誠、向井 邦晃
    • Organizer
      第3回PA・Aldosterone関連疾患研究会
    • Place of Presentation
      フクラシア東京ステーション (東京都千代田区)
    • Year and Date
      2016-02-06
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Presentation] 血管新生阻害薬に対して内因性耐性を示した進行性腎細胞癌症例の転帰2016

    • Author(s)
      篠島利明、水野隆一、松本一宏、森田伸也、篠田和伸、小坂威雄、菊地栄次、浅沼宏、宮嶋哲、大家基嗣
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2016-04-23
    • Data Source
      KAKENHI-PROJECT-15H04977
  • [Presentation] A case report: Nodule development from subcapsular aldosterone-producing cell clusters causes hyperaldosteronism2016

    • Author(s)
      Koshiro Nishimoto, Tsugio Seki, Isao Kurihara, Kenichi Yokota, Masao Omura, Tetsuo Nishikawa, Hirotaka Shibata, Takeo Kosaka, Mototsugu Oya, Makoto Suematsu, Kuniaki Mukai
    • Organizer
      ENDO 2016
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2016-04-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Presentation] A novel pathology related to subcapsular aldosterone-producing cell clusters causes hyperaldosteronism.2016

    • Author(s)
      Koshiro Nishimoto, Tsugio Seki, Isao Kurihara, Kenichi Yokota, Masao Omura, Tetsuo Nishikawa, Hirotaka Shibata, Takeo Kosaka, Mototsugu Oya, Makoto Suematsu, Kuniaki Mukai.
    • Organizer
      AUA 2016
    • Place of Presentation
      San Diago、アメリカ合衆国
    • Year and Date
      2016-05-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Presentation] POSSIBLE INVOLVEMENT OF A NOVEL INTERMEDIATE LESION BETWEEN APCC AND APA IN A PRIMARY HYPERALDOSTERONISM PATIENT2016

    • Author(s)
      Minae Koga, Koshiro Nishimoto, Tsugio Seki, Kuniaki Mukai, Makoto Suematsu, Takeo Kosaka, Mototsugu Oya, Kohzoh Makita, Seishi Matsui, Yuya Tsurutani, Yoko Matsuzawa, Jun Saito, Masao Omura, Tetsuo Nishikawa
    • Organizer
      Conference on the Adrenal Cortex 2016
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2016-03-29
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Presentation] 加齢によるアルドステロン産生細胞クラスターの発生とヒト副腎皮質リモデリング.2016

    • Author(s)
      西本 紘嗣郎, 森田 伸也, 小坂 威雄, 大家 基嗣
    • Organizer
      第28回日本内分泌外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-05-26
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Presentation] 前立腺がんの病理に基づく治療戦略 低リスク前立腺癌におけるがん微小環境マーカーとしてのVasohibin-1発現の臨床的意義2016

    • Author(s)
      小林 裕章, 小坂 威雄, 三上 修治, 宮崎 保匡, 松本 一宏, 菊地 栄次, 宮嶋 哲, 亀山 香織, 佐藤 靖史, 大家 基嗣
    • Organizer
      第54回日本癌治療学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-20
    • Data Source
      KAKENHI-PROJECT-16K08657
  • [Presentation] A Case Report: Nodule Development from Subcapsular Aldosterone-Producing Cell Clusters Causes Hyperaldosteronism.2016

    • Author(s)
      Nishimoto K, Seki T, Kurihara I, Yokota K, Omura M, Nishikawa T, Shibata H, Kosaka T, Oya M, Suematsu M, Mukai K.
    • Organizer
      ENDO 2016
    • Place of Presentation
      Boston、アメリカ合衆国
    • Year and Date
      2016-04-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10650
  • [Presentation] 前立腺癌進展の分子メカニズムと去勢抵抗性前立腺癌に対する治療戦略2015

    • Author(s)
      小坂 威雄
    • Organizer
      日本癌学会
    • Place of Presentation
      愛知県 名古屋市 名古屋国際会議場
    • Year and Date
      2015-10-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-26861299
  • [Presentation] Plasma fibrinogen level independently predicts the prognosis of patients with non-metastatic renal cell carcinoma2015

    • Author(s)
      Obata J, Tanaka N, Mizuno R, Morita S, Shinoda K, Kosaka T, Shinojima T, Kikuchi E, Asanuma H, Miyajima A, Oya M
    • Organizer
      The 110th American Urological Association Annual Meeting
    • Place of Presentation
      ニューオーリンズ(アメリカ)
    • Year and Date
      2015-05-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04977
  • [Presentation] 難治性前立腺癌に対する再プログラム化戦略2015

    • Author(s)
      小坂 威雄
    • Organizer
      第74回日本癌学会学術集会 臓器別シンポジウム、前立腺癌進展の分子メカニズムと去勢抵抗性前立腺癌に対する治療戦略
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-26861299
  • [Presentation] AXL-Gas6カスケード亢進と上部尿路上皮癌術後の予後との関連2015

    • Author(s)
      服部盛也、菊地栄次、小坂威雄、宮嶋哲、三上修治、大家基嗣
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂(石川県金沢市)
    • Year and Date
      2015-04-18
    • Data Source
      KAKENHI-PROJECT-26462428
  • [Presentation] Predictors of renal dysfunction during everolimus treatment in patients with metastatic renal cell carcinoma2015

    • Author(s)
      Mizuno R, Takahashi R, Shinojima T, Kosaka T, Miyajima A, Oya M
    • Organizer
      2015 ASCO Annual Meeting
    • Place of Presentation
      シカゴ(アメリカ)
    • Year and Date
      2015-05-29
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04977
  • [Presentation] 常識を疑う前立腺癌の挙動2015

    • Author(s)
      小坂 威雄
    • Organizer
      第3回泌尿器画像診断・治療技術研究会
    • Place of Presentation
      ウェスティン都ホテル京都(京都府京都市)
    • Year and Date
      2015-09-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-26861299
  • [Presentation] 前立腺癌がん治療の治療個別化ストラテジー2015

    • Author(s)
      小坂 威雄
    • Organizer
      日本がん治療学会
    • Place of Presentation
      京都府 京都市 国立京都国際会館
    • Year and Date
      2015-10-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-26861299
  • [Presentation] 尿路上皮癌におけるニコチン曝露がPI3K/Akt pathwayに及ぼす影響の基礎的検討2015

    • Author(s)
      弓削和之、菊地栄次、安水洋太、萩原正幸、小坂威雄、宮嶋哲、飯沼誠一、大家基嗣
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂(石川県金沢市)
    • Year and Date
      2015-04-18
    • Data Source
      KAKENHI-PROJECT-26462428
  • [Presentation] ドセタキセル療法抵抗性前立腺癌に対するリバビリン併用ドセタキセル療法に関する非盲検非無作為化前向きパイロット臨床試験2015

    • Author(s)
      小坂威雄、前田高宏、長田浩彦、吉峰俊輔、篠島利明、水野隆一、篠田和伸、森田伸也、菊地栄次、宮嶋哲、大家基嗣
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      ホテル日航金沢(金沢県金沢市)
    • Year and Date
      2015-04-18
    • Data Source
      KAKENHI-PROJECT-26861299
  • [Presentation] 難治性前立腺癌に対する遺伝子発現プロファイルを標的とした新規治療戦略2015

    • Author(s)
      小坂 威雄
    • Organizer
      第第53回日本癌治療学会学術集会 前立腺癌:前立腺癌がん治療個別化の最前線:臓器別シンポジウム 去勢抵抗性前立腺癌に対する治療戦略
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-10-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-26861299
  • [Presentation] 去勢抵抗性前立腺癌におけるアンドロゲン産生系の生化学的解析2013

    • Author(s)
      小坂威雄,宮嶋哲,安水洋太,菊地栄次,大家基嗣
    • Organizer
      第32回アンドロロジー学会
    • Place of Presentation
      大阪グランキューブ大阪
    • Year and Date
      2013-07-26
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 「腎癌up to date 個別化医療をめざして」 腎細胞癌における上皮-間葉転換と分子標的治療2013

    • Author(s)
      三上 修治, 水野 隆一, 小坂 威男, 大家 基嗣, 岡田 保典
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Invited
    • Data Source
      KAKENHI-PROJECT-25460422
  • [Presentation] A new strategy for castration resistant prostate cancer with targeting to feedback mechanisms of PI3K/AKT/mTOR pathway2013

    • Author(s)
      5: Yasumizu Y, Miyajima A, Kosaka T, Kikuchi E, Oya M
    • Organizer
      American Urological Association Annual Meeting
    • Place of Presentation
      Sandiego USA
    • Year and Date
      2013-05-06
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 前立腺癌における新規血管新生マーカーの発現の検討2013

    • Author(s)
      小坂威雄,宮崎保匡,宮嶋哲、三上修治,安水洋太,菊地栄次,田中川健,岡田保典,佐藤靖史,大家基嗣
    • Organizer
      第29回前立腺シンポジウム
    • Place of Presentation
      東京品川コンベンションセンター
    • Year and Date
      2013-12-14
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 去勢抵抗性前立腺癌における5α還元酵素活性の解析2013

    • Author(s)
      小坂 威雄
    • Organizer
      第22回 泌尿器科分子細胞研究会
    • Place of Presentation
      高知
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] Intracrine dynamics of CYP17A1 activities in human castration resistant prostate cancer2013

    • Author(s)
      Kosaka T, Miyajima A, Nagata H, Maeda T,Kikuchi E, Oya M
    • Organizer
      American Urological Association Annual Meeting
    • Place of Presentation
      Sandiego USA
    • Year and Date
      2013-05-05
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] アンドロゲン産生系に着目した去勢抵抗性前立腺癌の生化学的解析2013

    • Author(s)
      小坂威雄,宮嶋哲,長田浩彦、前田高宏、安水洋太,菊地栄次,大家基嗣
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      札幌ロイトン札幌
    • Year and Date
      2013-04-25
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 上部尿路上皮癌における新規血管新生制御因子Vasohibin-1発現の臨床的意義2013

    • Author(s)
      宮崎保匡,小坂威雄,三上修治,菊地栄次,田中伸之,前田高宏,石田勝,宮嶋哲,中川健,岡田保典,佐藤靖史,大家基嗣
    • Organizer
      日本癌治療学会
    • Place of Presentation
      横浜パシフィコ横浜
    • Year and Date
      2013-09-14
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] アンドロゲン産生系に着目した去勢抵抗性前立腺癌の生化学的解析2013

    • Author(s)
      小坂 威雄
    • Organizer
      第101回 日本泌尿器科学会総会
    • Place of Presentation
      北海道
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] PI3K-mTORシグナル阻害剤は去勢抵抗性前立腺癌においてドセタキセルへの感受性を増大させる2013

    • Author(s)
      安水洋太,宮嶋哲,小坂威雄,宮崎保匡、菊地栄次,大家基嗣
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜パシフィコ横浜
    • Year and Date
      2013-10-05
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 去勢抵抗性前立腺癌におけるCYP17A1活性(Direct evidence of dual CYP17A1 activities in human castration resistant prostate cancer)2012

    • Author(s)
      小坂威雄,宮嶋哲,菊地栄次,大家基嗣
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌ロイトン札幌
    • Year and Date
      2012-09-20
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 進行前立腺癌におけるアンドロゲン産生系の解析2012

    • Author(s)
      小坂 威雄
    • Organizer
      前立腺シンポジウム
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 去勢抵抗性前立腺癌に対するPI3K・mTORC1/2阻害剤とドセタキセル併用効果についての検討(Combination Therapy with PI3K-mTOR Pathway Inhibitor and Docetaxel in Castration Resistant Prostate Cancer)2012

    • Author(s)
      安水洋太,宮嶋哲,小坂威雄,城武卓,菊地栄次,大家基嗣
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌ロイトン札幌
    • Year and Date
      2012-09-20
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 上部尿路上皮癌におけるVasohibin-1の発現に関する予後因子として検討(The prognostic significance of vasohibin-1 expression in patients with upper urinary tract urothelial carcinoma)2012

    • Author(s)
      宮崎保匡,小坂威雄,三上修治,菊地栄次,田中伸之,前田高宏,石田勝,宮嶋哲,中川健,岡田保典,佐藤靖史,大家基嗣
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌ロイトン札幌
    • Year and Date
      2012-09-20
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 始原生殖細胞からの多能性幹細胞分化2011

    • Author(s)
      永松剛、小坂威雄, 他3名
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      新宿、東京
    • Year and Date
      2011-03-02
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Presentation] 始原生殖細胞からの多能性幹細胞分化2011

    • Author(s)
      永松剛、小坂威雄, 他3名
    • Organizer
      第10回 日本再生医療学会総会
    • Place of Presentation
      新宿、東京
    • Year and Date
      2011-03-02
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Presentation] Reprogramming primordial germ cells into pluripotent stem cells.2010

    • Author(s)
      小坂威雄, 他5名
    • Organizer
      第8回幹細胞シンポジウム
    • Place of Presentation
      淡路、兵庫
    • Year and Date
      2010-05-14
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Presentation] ATM deficiency decreases reprogramming efficiency in iPS cells.2010

    • Author(s)
      木下泰輔、永松剛、小坂威雄, 他3名
    • Organizer
      第8回幹細胞シンポジウム
    • Place of Presentation
      淡路、兵庫
    • Year and Date
      2010-05-14
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Presentation] Activation of the aryl hydrocarbon receptor is associated with cigarette smoke, poor prognosis and cancer cell invasion in renal cell carcinoma.2010

    • Author(s)
      Ishida M., Mikami S., Kosaka T., Kono H., Kikuchi E., Nagata H., Miyajima A., Nakagawa K., Mukai M., Okada Y., Oya M.
    • Organizer
      25^<th> Anniversary Congress of the European Association of Urology
    • Place of Presentation
      Barcelona
    • Year and Date
      2010-04-17
    • Data Source
      KAKENHI-PROJECT-21390445
  • [Presentation] ATM deficiency decreases reprogramming efficiency in iPS cells.2010

    • Author(s)
      木下泰輔、永松剛、小坂威雄, 他3名
    • Organizer
      第8回 幹細胞シンポジウム
    • Place of Presentation
      淡路、兵庫
    • Year and Date
      2010-05-14
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Presentation] Reprogramming primordial germ cells into pluripotent stem cells without basic FGF.2010

    • Author(s)
      小坂威雄, 他5名
    • Organizer
      幹細胞シンポジウム
    • Place of Presentation
      淡路、兵庫
    • Year and Date
      2010-05-14
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Presentation] Reprogramming Primordial germ cells into pluripotent stem cells without basic FGF.2009

    • Author(s)
      小坂威雄, 他5名
    • Organizer
      幹細胞シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-05-16
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Presentation] Prospective analysis of reprogramming process in primordial germ cells.2009

    • Author(s)
      小坂威雄, 他5名
    • Organizer
      第7回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-05-16
    • Data Source
      KAKENHI-PROJECT-21791527
  • [Presentation] 去勢抵抗性前立腺癌におけるアンドロゲン産生系の生化学的解析

    • Author(s)
      小坂 威雄、宮嶋 哲、安水 洋太、菊地 栄次、大家 基嗣
    • Organizer
      第32回 アンドロロジー学会
    • Place of Presentation
      グランキュ-ブ大阪(大阪)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 尿路上皮癌における抗がん剤耐性克服とEMT制御

    • Author(s)
      田中伸之 小坂威雄 宮﨑保匡 丹羽直也 水野隆一 菊地栄次 宮嶋哲 大家基嗣
    • Organizer
      第24回泌尿器科分子・細胞研究会
    • Place of Presentation
      JPタワー(東京都千代田区)
    • Year and Date
      2015-02-27 – 2015-02-28
    • Data Source
      KAKENHI-PROJECT-26462429
  • [Presentation] Intracrine dynamics of CYP17A1 activities in human castration resistant prostate cancer

    • Author(s)
      Kosaka T, Miyajima A, Nagata H, Maeda T, Kikuchi E, Oya M.
    • Organizer
      American Urological Asociation Annual Meeting
    • Place of Presentation
      Sandiego (USA)
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 抗がん剤耐性前立腺癌における、がん幹細胞関連遺伝子ネットワークを標的とした新規治療戦略

    • Author(s)
      小坂 威雄、永松 剛、宮嶋 哲、三上 修治、斎藤 秀、宮崎 保匡、安水 洋太、水野 隆一、菊地 栄次、中川 健、堀本 勝久、岡田 保典、須田 年生、大家 基嗣
    • Organizer
      第102回 日本泌尿器科学会総会
    • Place of Presentation
      神戸国際展示場(神戸)
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] PI3K-mTORシグナル阻害剤は去勢抵抗性前立腺癌においてドセタキセルへの感受性を増大させる

    • Author(s)
      安水 洋太、宮嶋 哲、小坂 威雄、宮崎 保匡、菊地 栄次、大家 基嗣
    • Organizer
      第72回 日本癌学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 前立腺癌のがん幹細胞性遺伝子ネットワークを標的とした革新的新規治療戦略の確立

    • Author(s)
      小坂 威雄、永松 剛、宮嶋 哲、三上 修治、斎藤 秀、宮崎 保匡、安水 洋太、水野 隆一、菊地 栄次、中川 健、堀本 勝久、岡田 保典、須田 年生、大家 基嗣
    • Organizer
      第23回 泌尿器科分子細胞研究会
    • Place of Presentation
      ホテルメトロポリタン(山形)
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 上部尿路上皮癌における新規術予後予測因子の検索

    • Author(s)
      服部盛也、菊地栄次、小坂威雄、、宮嶋哲、三上修治、大家基嗣
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26462428
  • [Presentation] A new strategy for castration resistant prostate cancer with targeting to feedback mechanism of PI3K/AKT/mTOR pathway

    • Author(s)
      Yasumizu Y, Kosaka T, Miyajima A,Kikuchi E, Oya M.
    • Organizer
      American Urological Asociation Annual Meeting
    • Place of Presentation
      Sandiego (USA)
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] アンドロゲン産生系に着目した去勢抵抗性前立腺癌の生化学的解析

    • Author(s)
      小坂 威雄、宮嶋 哲、長田 浩彦、前田 高宏、安水 洋太、服部 盛也、菊地 栄次、中川 健、大家 基嗣
    • Organizer
      第101回 日本泌尿器科学会総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Data Source
      KAKENHI-PROJECT-24890230
  • [Presentation] 前立腺癌における新規血管新生関連マーカーの発現の検討

    • Author(s)
      小坂 威雄、宮崎 保匡、宮嶋 哲、三上 修治、安水 洋太、菊地 栄次、中川 健、岡田 保典、佐藤 靖史、大家 基嗣
    • Organizer
      第29回前立腺シンポジウム
    • Place of Presentation
      品川コンベンションセンター(東京)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24890230
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