Kosaka Takeo 小坂威雄

… Alternative Names

TAKEO Kosaka 小坂威雄

KOSAKA Takeo 小坂威雄

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Researcher Number	30445407
Other IDs	https://orcid.org/0000-0002-1624-6676
Affiliation (Current)	2024: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 慶應義塾大学, 医学部(信濃町), 講師 2017: 慶應義塾大学, 医学部, 助教 2017: 慶應義塾大学, 医学部, 講師 2016: 慶應義塾大学, 医学部(信濃町), 講師 2014 – 2015: 慶應義塾大学, 医学部, 講師 … More 2014: 慶応義塾大学, 医学部, 助教 2012 – 2014: 慶應義塾大学, 医学部, 助教 2010: Keio University, 医学部, 研究員 2009 – 2010: Keio University, 医学部, 研究員(非常勤) Less
Review Section/Research Field	Principal Investigator Urology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56030:Urology-related Except Principal Investigator Basic Section 56030:Urology-related / Urology / Human pathology / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator 前立腺癌 / 薬剤耐性 / シングルセル解析 / 去勢抵抗性前立腺癌 / 次世代シーケンサー / リキッドバイオプシー / 血液循環腫瘍細胞 / 神経内分泌がん / 腫瘍内不均一性 / リプログラミング … More / C4-2AT6 / アンドロゲン / 個別化治療 / オルガノイド / 免疫逃避機構 / 代謝リプログラミング / 尿路上皮癌 / 血液循環がん細胞 / セルフリーDNA / 遺伝子パネル検査 / cfDNA / 遺伝子ネットワーク / がん幹細胞 / 再プログラム化 / CRPC / リプログラミング療法 / ドラッグリポジショニング / バイオインフォマティクス / 幹細胞 / 去勢抵抗性 / 5α還元酵素 / VASH1 / 微小環境 / 血管新生 / 精子幹細胞 / iPS細胞 / エピジェネシス / 多能性幹細胞 … More Except Principal Investigator 血管新生 / 分子標的治療 / 腎細胞癌 / 上皮間葉転換 / 尿路上皮癌 / 膀胱癌 / 免疫チェックポイント阻害剤 / 耐性 / MUC1 / 前立腺癌 / 神経内分泌前立腺癌 / 腫瘍内不均一性 / 免疫治療 / がん微小環境 / 癌化 / バソヒビン / 血管新生阻害剤 / 抗体療法 / 抗癌剤耐性 / 次世代シーケンサー / バイオマーカー / シスプラチン / 喫煙 / 予後 / 癌幹細胞 / 浸潤 / 転移 / リキッドバイオプシー / 尿路上皮がん / がん免疫ゲノミクス / 多様性解析 / Myc / NeuroD1 / ASCL1 / DN修復経路 / タキサン系抗癌剤耐性 / DNA修復経路 / DNA損傷応答 / 去勢抵抗性前立腺癌 / アンドロゲンレセプター / SWISNF / クロマチンリモデリング / ARID1A / BRG1 / SWI/SNF / がん組織不均一性 / 循環腫瘍細胞 / 膨張顕微鏡法 / 免疫微小環境 / ライトシート顕微鏡 / RNAシークエンス / 免疫療法 / シークエンス / イメージング / ドラッグ・リポジショニング / 膀胱内注入療法 / PDE5阻害薬 / 筋層非浸潤性性膀胱癌 / PDE５阻害薬 / 抗癌剤膀胱内注入 / Mitomycin C / 酸化ストレス / Tadalafil / 筋層非浸潤性膀胱癌 / 免疫応答 / 癌微小環境 / 前向き研究 / 放射線治療 / 高線量率組織内照射 / 高線量率組織内放射線照射 / 根治的前立腺全摘術 / 高リスク前立腺癌 / QOL調査 / 放射線療法 / 小線源療法 / 治療戦略 / 薬剤耐性 / 免疫 / ソラフェニブ / スニチニブ / VEGF-TKI / コンパニオン診断 / 腫瘍免疫 / 微小血管密度 / VASH1 / PD-L1 / PD-1 / プレシージョンメディスン / 微小環境 / 癌 / 免疫チェックポイント阻害薬 / リスク分類 / 治療抵抗性 / 副腎皮質 / KCNJ5 / アルドステロン産生細胞クラスター / pAATL / APCC / CYP11B2 / イオンポンプ (イオントランスポーター) / イオンチャネル / 体細胞変異 / アルドステロン産生細胞クラスター (APCC) / アルドステロン合成酵素 / 原発性アルドステロン症 / アルドステロン産生腺腫 / アルドステロン / MCP-1 / 単球 / 好中球 / ケモカイン / 耐性機序 / ユビキチン / 抗がん剤耐性 / FBXO32 / シグナル伝達 / 転写因子 / 抗癌剤 / 腎盂尿管癌 / 分子標的 / 併用効果 / 抗腫瘍効果 / PI3K/mTOR阻害剤 / アンドロゲン受容体阻害剤 / ドセタキセル抵抗性前立腺癌細胞株 / 治療耐性 / 分子標的薬 / 上皮ー間葉転換 / 上皮－間葉転換 / RANK / RANKL / 骨転移 / E-cadherin / Snail / 上皮-間葉転換 Less

Elucidation of the molecular control mechanism of refractory prostate cancer that includes lineage plasticity and establishment of individualized treatment strategiesPrincipal Investigator
- Principal Investigator
  
  小坂威雄
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
神経内分泌前立腺癌からダブルネガティブ前立腺癌への脱分化機構の解明
- Principal Investigator
  
  安水洋太
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
Elucidation of tumor development mechanism by immune escape mechanism through metabolic reprogramming of anticancer drug-resistant cancerPrincipal Investigator
- Principal Investigator
  
  小坂威雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Keio University
尿路上皮癌の腫瘍血管微小環境の不均一性に着目したバソヒビンによる革新的治療戦略
- Principal Investigator
  
  宮崎保匡
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
In situな尿路上皮がん免疫ゲノミクス多様性解析とリキッドバイオプシーの確立
- Principal Investigator
  
  田中伸之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
抗癌剤耐性前立腺癌のゲノム不安定性の解析と合成致死を利用した新規治療戦略
- Principal Investigator
  
  本郷周
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
Single-cell analysis of neuroendocrine prostate cancer to elucidate pathophysiology and establish novel treatment strategyPrincipal Investigator
- Principal Investigator
  
  Kosaka Takeo
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Keio University
Significance of MUC1 and chromatin remodeling factor complexes in neuroendocrine prostate cancer
- Principal Investigator
  
  Yasumizu Yota
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
Integrated analysis of ITH in drug resistant prostate cancer by single cell analysisPrincipal Investigator
- Principal Investigator
  
  Kosaka Takeo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
Targeting cancer stem cells and spatial niches in kidney cancer: Unravelling intratumoral heterogeneity
- Principal Investigator
  
  TANAKA NOBUYUKI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
A prospective observational study of comparison between radical prostatectomy and radiation therapy for high risk prostate cancer
- Principal Investigator
  
  Oyama Masafumi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Saitama Medical University
Establishment of new therapy targeting immune response and angiogenesis regulator vasohibin in prostate cancer
- Principal Investigator
  
  Miyazaki Yasumasa
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
Drug repositioning approaches for novel intravesical treatment against bladder cancer
- Principal Investigator
  
  MATSUMOTO Kazuhiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
Development of novel therapeutic modality by integrated analysis of immune environment of renal cell carcinoma and remodeling after inhibition of angiogenesis
- Principal Investigator
  
  OYA Mototsugu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
Establishment of the novel treatment strategy against urothelial carcinoma controlling for cancer stem-like property
- Principal Investigator
  
  Kikuchi Eiji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  St. Marianna University School of Medicine
  Keio University
Search for biomarkers and novel therapeutic strategies targeting heterogeneity and plasticity in prostate cancerPrincipal Investigator
- Principal Investigator
  
  KOSAKA Takeo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Keio University
Study of the tumor microenvironment during progression and acquisition of treatment resistance of renal cell carcinoma
- Principal Investigator
  
  Mikami Shuji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
Role of chemokine in urothelial cancer progression
- Principal Investigator
  
  MIYAJIMA Akira
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Tokai University
  Keio University
Ealucidation of progression from aldosterone-producing cell cluster leading to aldosterone-producing adenoma
- Principal Investigator
  
  Nishimoto Koshiro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Saitama Medical University
  Keio University
Elucidation of refractory mechanism to the molecular targeted therapy for renal cell carcinoma
- Principal Investigator
  
  Oya Mototsugu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Keio University
Novel anti-cancer therapeutic strategy with mTORC1/2 inhibitor against bladder cancer
- Principal Investigator
  
  KIKUCHI EIJI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Keio University
Tumor microenvironment and ubiquitin system in platinum resistance urothelial carcinoma
- Principal Investigator
  
  TANAKA NOBUYUKI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Keio University
New strategy of Identifying a candidate drug of reprogramming prostate cancer by targeting gene networkPrincipal Investigator
- Principal Investigator
  
  KOSAKA TAKEO
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Keio University
Analysis of effect and resistance of molecular-targeted therapy in renal cell carcinoma
- Principal Investigator
  
  Mikami Shuji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
New treatment strategy of refractory prostate cancer by regulation of androgen-androgen receptor axis and PI3K/Akt pathway
- Principal Investigator
  
  ISHIOKA KATSURA
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Keio University
Castration resistant prostate cancer with drug resistance and tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  TAKEO Kosaka
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Urology
- Research Institution
  Keio University
Microenviroment and organ specific metastases in urological cancers as tools to elucidate molecular mechanism of carcinogenesis and tumor development.
- Principal Investigator
  
  OYA Mototsugu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Keio University
The prospective analysis in generation of pluripotency in primordial germ cellsPrincipal Investigator
- Principal Investigator
  
  KOSAKA Takeo
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Keio University

[Book] 前立腺癌-基礎・臨床研究の最新知見2016
- Author(s)
  小坂威雄, 大家基嗣　（分担執筆）
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-26861299
[Journal Article] IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer2023
- Author(s)
  Shigeta Keisuke、Hasegawa Masanori、Hishiki Takako、Naito Yoshiko、Baba Yuto、Mikami Shuji、Matsumoto Kazuhiro、Mizuno Ryuichi、Miyajima Akira、Kikuchi Eiji、Saya Hideyuki、Kosaka Takeo、Oya Mototsugu
- Journal Title
  
  The EMBO Journal
  
  Volume: 42 Issue: 4 Pages: 1-27
- DOI
  10.15252/embj.2022110620
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-21K19579, KAKENHI-PROJECT-21K20811
[Journal Article] Prognostic role of the innate immune signature CD163 and “eat me” signal calreticulin in clear cell renal cell carcinoma2023
- Author(s)
  Anno Tadatsugu、Tanaka Nobuyuki、Takamatsu Kimiharu、Hakozaki Kyohei、Kufukihara Ryohei、Baba Yuto、Takeda Toshikazu、Matsumoto Kazuhiro、Morita Shinya、Kosaka Takeo、Mikami Shuji、Nishihara Hiroshi、Mizuno Ryuichi、Oya Mototsugu
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: - Issue: 6 Pages: 1779-1788
- DOI
  10.1007/s00262-023-03369-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09411, KAKENHI-PROJECT-21K19414, KAKENHI-PROJECT-22K16794, KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-23K24476
[Journal Article] Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy2022
- Author(s)
  Kosaka Takeo、Hongo Hiroshi、Hayashi Hideyuki、Nakamura Kohei、Nishihara Hiroshi、Mikami Shuji、Beltran Himisha、Oya Mototsugu
- Journal Title
  
  Asian Journal of Andrology
  
  Volume: 24 Issue: 1 Pages: 116-116
- DOI
  10.4103/aja.aja_37_21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K09436, KAKENHI-PROJECT-21K19579, KAKENHI-PROJECT-20K18232
[Journal Article] Characterizing cyclin-dependent kinase 12(CDK12)-altered aggressive prostate cancer: a twelve-case series2022
- Author(s)
  Iwasawa Tomohiro、Kosaka Takeo、Yasumizu Yota、Hongo Hiroshi、Yanai Yoshinori、Baba Yuto、Matsumoto Kazuhiro、Nakamura Kohei、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 27 Issue: 12 Pages: 1867-1873
- DOI
  10.1007/s10147-022-02248-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K19579
[Journal Article] Influence of response to prior docetaxel on sensitivity to cabazitaxel in prostate cancer patients with PTEN alterations2022
- Author(s)
  Kamisawa Ken、Kosaka Takeo、Nakamura Kohei、Yasumizu Yota、Hongo Hiroshi、Takeda Toshikazu、Matsumoto Kazuhiro、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 9 Pages: 3161-3168
- DOI
  10.1111/cas.15473
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K19579
[Journal Article] Hybridisation chain reaction-based visualisation and screening for lncRNA profiles in clear-cell renal-cell carcinoma2022
- Author(s)
  Kufukihara Ryohei、Tanaka Nobuyuki、Takamatsu Kimiharu、Niwa Naoya、Fukumoto Keishiro、Yasumizu Yota、Takeda Toshikazu、Matsumoto Kazuhiro、Morita Shinya、Kosaka Takeo、Aimono Eriko、Nishihara Hiroshi、Mizuno Ryuichi、Oya Mototsugu
- Journal Title
  
  British Journal of Cancer
  
  Volume: 127 Issue: 6 Pages: 1133-1141
- DOI
  10.1038/s41416-022-01895-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09356, KAKENHI-PROJECT-21K19414, KAKENHI-PROJECT-22K16794, KAKENHI-PROJECT-23K24476
[Journal Article] The first Japanese case of intraductal cancer of the prostate with checkpoint kinase 2 mutation2022
- Author(s)
  Hongo Hiroshi、Kosaka Takeo、Nakamura Kohei、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  Asian Journal of Urology
  
  Volume: 9 Issue: 4 Pages: 480-482
- DOI
  10.1016/j.ajur.2022.02.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09436, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-21K19579
[Journal Article] Genomic analysis of aggressive ductal adenocarcinoma of the prostate2022
- Author(s)
  Kobayashi Hiroaki、Kosaka Takeo、Nakamura Kohei、Kimura Tokuhiro、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 7 Pages: 8445-8451
- DOI
  10.1002/cam4.5573
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817
[Journal Article] Squamous cell carcinoma of the prostate with SMARCA4 alteration in a Japanese patient2022
- Author(s)
  Kaneko Yuta、Kosaka Takeo、Nakamura Kohei、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  IJU Case Reports
  
  Volume: 5 Issue: 5 Pages: 323-326
- DOI
  10.1002/iju5.12466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-19K07468
[Journal Article] A long-term survivor of metastatic neuroendocrine prostate cancer treated with multimodal therapy: genetic consideration from next-generation sequencing2021
- Author(s)
  Hongo Hiroshi、Kosaka Takeo、Nakatsuka Seishi、Oya Mototsugu
- Journal Title
  
  International Cancer Conference Journal
  
  Volume: - Issue: 3 Pages: 174-180
- DOI
  10.1007/s13691-021-00482-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22822, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K09436, KAKENHI-PROJECT-21K19579
[Journal Article] Prominent response to platinum‐based chemotherapy in a patient with BRCA2 mutant‐neuroendocrine prostate cancer and MDM2 amplification2021
- Author(s)
  Daimon Tatsuaki、Kosaka Takeo、Hongo Hiroshi、Aimono Eriko、Nakamura Kohei、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  IJU Case Reports
  
  Volume: 4 Issue: 4 Pages: 216-219
- DOI
  10.1002/iju5.12287
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K18232
[Journal Article] Discovery of a new candidate drug to overcome cabazitaxel-resistant gene signature in castration-resistant prostate cancer by in silico screening2021
- Author(s)
  Hongo Hiroshi、Kosaka Takeo、Suzuki Yoko、Oya Mototsugu
- Journal Title
  
  Prostate Cancer and Prostatic Diseases
  
  Volume: - Issue: 1 Pages: 59-66
- DOI
  10.1038/s41391-021-00426-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22822, KAKENHI-PROJECT-21K09436
[Journal Article] First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations2021
- Author(s)
  Omura Minami、Kosaka Takeo、Aimono Eriko、Nakamura Kohei、Hongo Hiroshi、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  IJU Case Reports
  
  Volume: 5 Issue: 1 Pages: 41-44
- DOI
  10.1002/iju5.12383
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19579, KAKENHI-PROJECT-20K18232
[Journal Article] Topoisomerase II alpha inhibition can overcome taxane-resistant prostate cancer through DNA repair pathways.2021
- Author(s)
  Hongo H, Kosaka T, Suzuki Y, Mikami S, Fukada J, Oya M.
- Journal Title
  
  Scientific Report
  
  Volume: - Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-021-01697-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22822, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K07606, KAKENHI-PROJECT-21K09436
[Journal Article] CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer2021
- Author(s)
  Yanai Yoshinori、Kosaka Takeo、Mikami Shuji、Hongo Hiroshi、Yasumizu Yota、Takeda Toshikazu、Matsumoto Kazuhiro、Miyauchi Jun、Kitano Shigehisa、Oya Mototsugu
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-7
- DOI
  10.1038/s41598-021-01900-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03817
[Journal Article] A first case of ductal adenocarcinoma of the prostate having characteristics of neuroendocrine phenotype with PTEN, RB1 and TP53 alterations2021
- Author(s)
  Kobayashi Hiroaki、Kosaka Takeo、Nakamura Kohei、Shojo Kazunori、Hongo Hiroshi、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  BMC Medical Genomics
  
  Volume: 14 Issue: 1 Pages: 1-4
- DOI
  10.1186/s12920-021-01093-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19579
[Journal Article] Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer2021
- Author(s)
  Takayama Ken-ichi、Kosaka Takeo、Suzuki Takashi、Hongo Hiroshi、Oya Mototsugu、Fujimura Tetsuya、Suzuki Yutaka、Inoue Satoshi
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 3766-3766
- DOI
  10.1038/s41467-021-23974-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-20K21667, KAKENHI-PROJECT-21H04829, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K07350
[Journal Article] First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion2021
- Author(s)
  Shojo Kazunori、Kosaka Takeo、Nakamura Kohei、Hongo Hiroshi、Kobayashi Hiroaki、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  IJU Case Reports
  
  Volume: 4 Issue: 3 Pages: 176-179
- DOI
  10.1002/iju5.12274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K18232
[Journal Article] A first Japanese case of BRCA2 and RB1 co-loss organ-confined prostate cancer successfully treated by radical prostatectomy2021
- Author(s)
  Matsumoto Kazuhiro、Kosaka Takeo、Nakamura Kohei、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  International Cancer Conference Journal
  
  Volume: 10(3) Issue: 3 Pages: 170-173
- DOI
  10.1007/s13691-021-00469-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K18232
[Journal Article] Significance of tumor microenvironment in acquiring resistance to vascular endothelial growth factor‐tyrosine kinase inhibitor and recent advance of systemic treatment of clear cell renal cell carcinoma2020
- Author(s)
  Mikami Shuji、Mizuno Ryuichi、Kosaka Takeo、Tanaka Nobuyuki、Kuroda Naoto、Nagashima Yoji、Okada Yasunori、Oya Mototsugu
- Journal Title
  
  Pathology International
  
  Volume: 70 Issue: 10 Pages: 712-723
- DOI
  10.1111/pin.12984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-18H02939
[Journal Article] Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report2020
- Author(s)
  Hongo Hiroshi、Kosaka Takeo、Aimono Eriko、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  Diagnostic Pathology
  
  Volume: 15 Issue: 1 Pages: 916-919
- DOI
  10.1186/s13000-019-0916-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11158
[Journal Article] Role of the MUC1‐C oncoprotein in the acquisition of cisplatin resistance by urothelial carcinoma2020
- Author(s)
  Shigeta Keisuke、Hasegawa Masanori、Kikuchi Eiji、Yasumizu Yota、Kosaka Takeo、Mizuno Ryuichi、Mikami Shuji、Miyajima Akira、Kufe Donald、Oya Mototsugu
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 10 Pages: 3639-3652
- DOI
  10.1111/cas.14574
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-18H02939, KAKENHI-PROJECT-19K18599
[Journal Article] CDK12 and HER2 coamplification in two urothelial carcinomas with rapid and aggressive clinical progression2020
- Author(s)
  Yanai Yoshinori、Kosaka Takeo、Nakamura Kohei、Aimono Eriko、Matsumoto Kazuhiro、Morita Shinya、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 12 Pages: 4652-4655
- DOI
  10.1111/cas.14672
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817
[Journal Article] Pulmonary metastasis secondary to abiraterone‐resistant prostate cancer with homozygous deletions of BRCA2: First Japanese case2020
- Author(s)
  Izawa Mizuki、Kosaka Takeo、Nakamura Kohei、Oba Junna、Hishida Tomoyuki、Hongo Hiroshi、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  IJU Case Reports
  
  Volume: 4 Issue: 1 Pages: 14-17
- DOI
  10.1002/iju5.12224
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817
[Journal Article] A first Japanese case of neuroendocrine prostate cancer accompanied by lung and brain metastasis with somatic and germline BRCA2 mutation2019
- Author(s)
  Kosaka Takeo、Hongo Hiroshi、Aimono Eriko、Matsumoto Kazuhiro、Hayashida Tetsu、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
- Journal Title
  
  Pathology International
  
  Volume: 69 Issue: 12 Pages: 715-720
- DOI
  10.1111/pin.12860
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11158
[Journal Article] Factors affecting renal function preservation among patients not achieving trifecta after laparoscopic partial nephrectomy for clinical T1a renal masses2019
- Author(s)
  Takeda Toshikazu、Komatsuda Akari、Yanai Yoshinori、Tanaka Nobuyuki、Matsumoto Kazuhiro、Morita Shinya、Kosaka Takeo、Mizuno Ryuichi、Shinojima Toshiaki、Asanuma Hiroshi、Oya Mototsugu
- Journal Title
  
  Asian Journal of Endoscopic Surgery
  
  Volume: － Issue: 4 Pages: 526-531
- DOI
  10.1111/ases.12776
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02939
[Journal Article] Prognostic value of serum C-reactive protein level prior to second-line treatment in intermediate risk metastatic renal cell carcinoma patients2019
- Author(s)
  Kimiharu Takamatsu, Ryuichi Mizuno, Nobuyuki Tanaka, Toshikazu Takeda, Shinya Morita, Kazuhiro Matsumoto, Takeo Kosaka, Toshiaki Shinojima, Eiji Kikuchi, Hiroshi Asanuma, Masafumi Oyama, Shuji Mikami, Mototsugu Oya
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 24 Issue: 9 Pages: 1069-1074
- DOI
  10.1007/s10147-019-01459-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09150, KAKENHI-PROJECT-18H02939, KAKENHI-PROJECT-17K11159
[Journal Article] Japanese Case of Enzalutamide-Resistant Prostate Cancer Harboring a SPOP Mutation With Scattered Allelic Imbalance: Response to Platinum-Based Therapy.2019
- Author(s)
  Watanabe K, Kosaka T, Aimono E, Hongo H, Mikami S, Nishihara H, Oya M
- Journal Title
  
  Clinical Genitourinary Cancer
  
  Volume: 17 Issue: 5 Pages: e897-e902
- DOI
  10.1016/j.clgc.2019.06.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-17K11158
[Journal Article] Complete response with early introduction of cabazitaxel in a patient with multiple lung metastases of castration-resistant prostate cancer following the early detection of metastases using liquid biopsy: a case report2019
- Author(s)
  Kosaka Takeo、Hongo Hiroshi、Oya Mototsugu
- Journal Title
  
  BMC Cancer
  
  Volume: 19 Issue: 1 Pages: 5782-5784
- DOI
  10.1186/s12885-019-5782-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11158
[Journal Article] TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells.2019
- Author(s)
  Niwa N, Tanaka N, Hongo H, Miyazaki Y, Takamatsu K, Mizuno R, Kikuchi E, Mikami S, Kosaka T, Oya M.
- Journal Title
  
  Laboratory Investigation
  
  Volume: 99 Issue: 11 Pages: 1702-1713
- DOI
  10.1038/s41374-019-0285-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-18K19482, KAKENHI-PUBLICLY-18H04906, KAKENHI-PROJECT-19H03792
[Journal Article] Sulfasalazine could modulate the CD 44v9‐xCT system and enhance cisplatin‐induced cytotoxic effects in metastatic bladder cancer2019
- Author(s)
  Ogihara Koichiro、Kikuchi Eiji、Okazaki Shogo、Hagiwara Masayuki、Takeda Toshikazu、Matsumoto Kazuhiro、Kosaka Takeo、Mikami Shuji、Saya Hideyuki、Oya Mototsugu
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 4 Pages: 1431-1441
- DOI
  10.1111/cas.13960
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-16K08657, KAKENHI-PROJECT-17K16812, KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-17K11158
[Journal Article] Evaluation of prostate-specific antigen density in the diagnosis of prostate cancer combined with magnetic resonance imaging before biopsy in men aged 70 years and older with elevated PSA.2018
- Author(s)
  Yanai Y, Kosaka T, Hongo H, Matsumoto K, Shinojima T, Kikuchi E, Miyajima A, Mizuno R, Mikami S, Jinzaki M, Oya M.
- Journal Title
  
  Mol Clin Oncol.
  
  Volume: 9 Pages: 656-660
- DOI
  10.3892/mco.2018.1725
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08657
[Journal Article] PKM2 under hypoxic environment causes resistance to mTOR inhibitor in human castration resistant prostate cancer2018
- Author(s)
  Yasumizu Yota、Hongo Hiroshi、Kosaka Takeo、Mikami Shuji、Nishimoto Koshiro、Kikuchi Eiji、Oya Mototsugu
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 45 Pages: 27698-27707
- DOI
  10.18632/oncotarget.25498
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-17K16813
[Journal Article] Analysis of cabazitaxel-resistant mechanism in human castration-resistant prostate cancer2018
- Author(s)
  Hongo Hiroshi、Kosaka Takeo、Oya Mototsugu
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 9 Pages: 2937-2945
- DOI
  10.1111/cas.13729
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-17K16813
[Journal Article] Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer2018
- Author(s)
  Hagiwara Masayuki, Kikuchi Eiji, Tanaka Nobuyuki, Kosaka Takeo, Mikami Shuji, Saya Hideyuki, Oya Mototsugu
- Journal Title
  
  BMC Cancer
  
  Volume: 18 Issue: 1
- DOI
  10.1186/s12885-018-3988-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08657, KAKENHI-PROJECT-17K11157
[Journal Article] No significant impact of patient age and prior treatment profile with docetaxel on the efficacy of cabazitaxel in patient with castration-resistant prostate cancer2018
- Author(s)
  Kosaka Takeo、Hongo Hiroshi、Watanabe Keitaro、Mizuno Ryuichi、Kikuchi Eiji、Oya Mototsugu
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: 82 Issue: 6 Pages: 1061-1066
- DOI
  10.1007/s00280-018-3698-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-17K16813
[Journal Article] Single-cell RNA-seq analysis reveals the platinum resistance gene COX7B and the surrogate marker CD632018
- Author(s)
  Tanaka Nobuyuki、Katayama Shintaro、Reddy Aparna、Nishimura Kaneyasu、Niwa Naoya、Hongo Hiroshi、Ogihara Koichiro、Kosaka Takeo、Mizuno Ryuichi、Kikuchi Eiji、Mikami Shuji、Miyakawa Ayako、Arenas Ernest、Kere Juha、Oya Mototsugu、Uhl?n Per
- Journal Title
  
  Cancer Medicine
  
  Volume: 7 Issue: 12 Pages: 6193-6204
- DOI
  10.1002/cam4.1828
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-18K19482, KAKENHI-PUBLICLY-18H04906, KAKENHI-PROJECT-16K08657
[Journal Article] Prognostic Value of Baseline Serum C-Reactive Protein Level in Intermediate-Risk Group Patients With Metastatic Renal-Cell Carcinoma Treated by First-Line Vascular Endothelial Growth Factor-Targeted Therapy.2018
- Author(s)
  Takamatsu K1, Mizuno R2, Omura M1, Morita S1, Matsumoto K1, Shinoda K1, Kosaka T1, Takeda T1, Shinojima T1, Kikuchi E1, Asanuma H1, Oyama M3, Mikami S4, Oya M1.
- Journal Title
  
  Clin Genitourin Cancer
  
  Volume: 16（4） Issue: 4 Pages: e927-e933
- DOI
  10.1016/j.clgc.2018.03.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11159, KAKENHI-PROJECT-18K09150, KAKENHI-PROJECT-18H02939
[Journal Article] Clinical outcome of high dose rate brachytherapy with external beam radiotherapy for high-risk prostate cancer: a single institutional retrospective study2018
- Author(s)
  Shirotake Suguru、Makino Soichi、Suzuki Kenjiro、Araki Ryuichiro、Kosaka Takeo、Nishimoto Koshiro、Oyama Masafumi、Kato Shingo
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 49 Issue: 1 Pages: 87-91
- DOI
  10.1093/jjco/hyy174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07642
[Journal Article] Vasohibin-1 as a novel microenvironmental biomarker for patient risk reclassification in low-risk prostate cancer2018
- Author(s)
  Kobayashi Hiroaki, Kosaka Takeo, Mikami Shuji, Miyazaki Yasumasa, Matsumoto Kazuhiro, Kikuchi Eiji, Miyajima Akira, Kameyama Kaori, Sato Yasufumi, Oya Mototsugu
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 12 Pages: 10203-10210
- DOI
  10.18632/oncotarget.23011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08657, KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-15K10609
[Journal Article] Prognostic significance of grade 3/4 neutropenia in Japanese prostate cancer patients treated with cabazitaxel.2018
- Author(s)
  Kosaka T, Shinojima T, Morita S, Oya M.
- Journal Title
  
  Cancer Sci.
  
  Volume: in press Issue: 5 Pages: 1570-1575
- DOI
  10.1111/cas.13556
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11158
[Journal Article] Aldosterone and 18-oxocortisol coaccumulation in aldosterone-producing lesions2018
- Author(s)
  Sugiura Yuki, Takeo Emi, Shimma Shuichi, Yokota Mai, Higashi Tatsuya, Seki Tsugio, Mizuno Yosuke, Oya Mototsugu Kosaka Takeo, Omura Masao, Nishikawa Tetsuo, Suematsu Makoto, Nishimoto Koshiro
- Journal Title
  
  Hypertension
  
  Volume: 72 Issue: 6 Pages: 1345-1354
- DOI
  10.1161/hypertensionaha.118.11243
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08250, KAKENHI-PROJECT-18K09205, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-18J20250, KAKENHI-PROJECT-15K10650
[Journal Article] Increased vasohibin-1 expression is associated with metastasis and poor prognosis of renal cell carcinoma patients.2017
- Author(s)
  Mikami S, Oya M, Kosaka T, Mizuno R, Miyazaki Y, Sato Y, Okada Y.
- Journal Title
  
  Lab Invest.
  
  Volume: － Issue: 7 Pages: 854-862
- DOI
  10.1038/labinvest.2017.26
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08657, KAKENHI-PROJECT-15H04977
[Journal Article] Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism2017
- Author(s)
  Nishimoto, K., Koga, M., Seki, T., Oki, K., Gomez-Sanchez, E.P., Gomez-Sanchez, C.E., Naruse, M., Sakaguchi, T., Morita, S., Kosaka, T., Oya, M., Ogishima, T., Yasuda, M., Suematsu, M., Kabe, T., Omura, M., Nishikawa, T., Mukai, K.
- Journal Title
  
  Mol. Cell. Endocrinol.
  
  Volume: 441 Pages: 124-133
- DOI
  10.1016/j.mce.2016.10.014
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461387, KAKENHI-PROJECT-26860707, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-15K10650
[Journal Article] Reactive oxygen species induction by cabazitaxel through inhibiting Sestrin-3 in castration resistant prostate cancer.2017
- Author(s)
  prostate cancer. Kosaka T, Hongo H, Miyazaki Y, Nishimoto K, Miyajima A, Oya M.
- Journal Title
  
  Oncotarget.
  
  Volume: 8(50) Issue: 50 Pages: 87675-87683
- DOI
  10.18632/oncotarget.21147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11158, KAKENHI-PROJECT-15K10609
[Journal Article] Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma2017
- Author(s)
  Daimon T, Kosaka T, Kikuchi E, Mikami S, Miyazaki Y, Hashimoto A, Hashimoto S, Mizuno R, Miyajima A, Okada Y, Sabe H, and Oya M
- Journal Title
  
  Urol Oncol
  
  Volume: 35(9) Issue: 9 Pages: 543.e17-543.e24
- DOI
  10.1016/j.urolonc.2017.04.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07151, KAKENHI-PROJECT-17K08614, KAKENHI-PROJECT-15K10609
[Journal Article] Somatic KCNJ5 mutation occurring early in adrenal development may cause a novel form of juvenile primary aldosteronism.2017
- Author(s)
  Tamura A, Nishimoto K, Seki T, Matsuzawa Y, Saito J, Omura M, Gomez-Sanchez CE, Makita K, Matsui S, Moriya N, Inoue A, Nagata M, Sasano H, Nakamura Y, Yamazaki Y, Kabe Y, Mukai K, Kosaka T, Oya M, Suematsu S, Nishikawa T.
- Journal Title
  
  Mol Cell Endocrinol.
  
  Volume: 441 Pages: 134-139
- DOI
  10.1016/j.mce.2016.07.031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04711, KAKENHI-PROJECT-26461387, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-15K10650
[Journal Article] Plasma fibrinogen level: An independent prognostic factor for disease-free survival and cancer-specific survival in patients with localized renal cell carcinoma2016
- Author(s)
  Obata J, Tanaka N, Mizuno R, Kanao K, Mikami S, Matsumoto K, Kosaka T, Kikuchi E, Jinzaki M, Oya M
- Journal Title
  
  BJU Int
  
  Volume: Epub ahead of print Issue: 4 Pages: 598-603
- DOI
  10.1111/bju.13414
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04977, KAKENHI-PROJECT-26462429
[Journal Article] A case report: Nodule development from subcapsular aldosterone-producing cell clusters causes hyperaldosteronism2016
- Author(s)
  Nishimoto K, Seki T, Kurihara I, Yokota K, Omura M, Nishikawa T, Shibata H, Kosaka T, Oya M, Suematsu M, Mukai K
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 101 Issue: 1 Pages: 6-9
- DOI
  10.1210/jc.2015-3285
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10650, KAKENHI-PROJECT-26461387, KAKENHI-PROJECT-25461254, KAKENHI-PROJECT-25461397
[Journal Article] Human adrenocortical remodeling leading to aldosterone-producing cell cluster generation2016
- Author(s)
  Nishimoto, K., Seki, T., Hayashi, Y., Mikami, S., Al-Eyd, G., Nakagawa, K., Morita, S., Kosaka, T., Oya, M., Mitani, F., Suematsu, M., Kabe, T., Mukai, K.
- Journal Title
  
  Int. J. Endocrinol.
  
  Volume: 2016 Pages: 7834356-7834356
- DOI
  10.1155/2016/7834356
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461387, KAKENHI-PROJECT-15K10650
[Journal Article] Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.2016
- Author(s)
  Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhl P, Suematsu M, Oya M.
- Journal Title
  
  JCI Insight
  
  Volume: 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10609
[Journal Article] Relationship between increased expression of the Axl/Gas6 signal cascade and prognosis of patients with upper tract urothelial carcinoma.2016
- Author(s)
  Hattori S, Kikuchi E, Kosaka T, Miyazaki Y, Tanaka N, Miyajima A, Mikami S, Oya M
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 23 Issue: 2 Pages: 663-670
- DOI
  10.1245/s10434-015-4848-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462428, KAKENHI-PROJECT-26861296
[Journal Article] Acquired platinum resistance involves epithelial-to-mesenchymal transition through ubiquitin ligase FBXO32 dysregulation2016
- Author(s)
  Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhlen P, Suematsu M, Oya M
- Journal Title
  
  JCI insight
  
  Volume: 1 Issue: 18
- DOI
  10.1172/jci.insight.83654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04723, KAKENHI-PROJECT-26293057, KAKENHI-PROJECT-26462429, KAKENHI-PROJECT-15K15057, KAKENHI-PROJECT-26670163, KAKENHI-PROJECT-15K20110
[Journal Article] Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.2016
- Author(s)
  Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhlen P, Suematsu M, Oya M.
- Journal Title
  
  JCI Insight
  
  Volume: 1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08657
[Journal Article] High Absolute Monocyte Count Predicts Poor Clinical Outcome in Patients with Castration-Resistant Prostate Cancer Treated with Docetaxel Chemotherapy.2016
- Author(s)
  Shigeta K, Kosaka T, Kitano S, Yasumizu Y, Miyazaki Y, Mizuno R, Shinojima T, Kikuchi E, Miyajima A, Tanoguchi H, Hasegawa S, Oya M.
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 23(12) Issue: 12 Pages: 4115-4122
- DOI
  10.1245/s10434-016-5354-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460981, KAKENHI-PROJECT-15K10609
[Journal Article] Should We Try Antiandrogen Withdrawal in Castration-Resistant Prostate Cancer Patients? Insights From a Retrospective Study.2016
- Author(s)
  Hongo H, Kosaka T, Mizuno R, Ezaki T, Matsumoto K, Morita S, Shinoda K, Shinojima T, Kikuchi E, Miyajima A, Oya M.
- Journal Title
  
  Clinical Genitourinary Cancer
  
  Volume: Epub ahead of print Issue: 6 Pages: e569-e573
- DOI
  10.1016/j.clgc.2016.02.014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K20109, KAKENHI-PROJECT-26861299, KAKENHI-PROJECT-16K20161
[Journal Article] The prognostic significance of OCT4 expression in patients with prostate cancer. Human Pathology 2016 in press2016
- Author(s)
  Kosaka T, Mikami S, Yoshimine S, Miyazaki Y, Daimin T, Kikuchi E, Miyajima A, Oya M.
- Journal Title
  
  Human Pathology 2016 in press
  
  Volume: in press Pages: 1-8
- DOI
  10.1016/j.humpath.2015.12.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26861299
[Journal Article] Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer.2015
- Author(s)
  Y. Ito, E. Kikuchi, N. Tanaka, T. Kosaki, E. Suzuki, R. Mizuno, T. Shinojima, A. Miyajima, K. Umezawa and M. Oya
- Journal Title
  
  BMC Cancer
  
  Volume: 15 Issue: 1 Pages: 324-324
- DOI
  10.1186/s12885-015-1315-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-26462429, KAKENHI-PROJECT-26750362
[Journal Article] Impact of Combined Use of Blood-based Inflammatory Markers on Patients with Upper Tract Urothelial Carcinoma Following Radical Nephroureterectomy: Proposal of a Cumulative Marker Score as a Novel Predictive Tool for Prognosis2015
- Author(s)
  Nobuyuki Tanaka, Eiji Kikuchi, Kent Kanao, Kazuhiro Matsumoto, Suguru Shirotake, Yasumasa Miyazaki, Hiroaki Kobayashi, Gou Kaneko, Masayuki Hagiwara, Hiroki Ide, Jun Obata, Katsura Hoshino, Nozomi Hayakawa, Takeo Kosaka, Satoshi Hara, Ken Nakagawa, Masahiro Jinzaki, Mototsugu Oya
- Journal Title
  
  European Urology Focus
  
  Volume: 1 Issue: 1 Pages: 54-63
- DOI
  10.1016/j.euf.2015.02.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462429
[Journal Article] Renin-angiotensin system blockade: Its contribution and controversy.2015
- Author(s)
  Miyajima A, Kosaka T, Kikuchi E, Oya M.
- Journal Title
  
  Int J Urol
  
  Volume: 22 Issue: 8 Pages: 721-730
- DOI
  10.1111/iju.12827
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10609
[Journal Article] Prognostic Impact of Renin-Angiotensin System Blockade on Renal Cell Carcinoma After Surgery.2015
- Author(s)
  Miyajima A, Yazawa S, Kosaka T, Tanaka N, Shirotake S, Mizuno R, Kikuchi E, Oya M.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 22 Issue: 11 Pages: 3751-3759
- DOI
  10.1245/s10434-015-4436-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10609, KAKENHI-PROJECT-15H04977
[Journal Article] Efficacy of treatment with a GnRH antagonist in prostate cancer patients previously treated with a GnRH agonist.2015
- Author(s)
  Ezaki T, Kosaka T, Mizuno R, Shinojima T, Kikuchi E, Miyajima A, Oya M.
- Journal Title
  
  Cancer Chemother Pharmacol. 2015 Aug;76(2):301-6.
  
  Volume: Aug;76(2): Issue: 2 Pages: 301-6
- DOI
  10.1007/s00280-015-2798-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26861299
[Journal Article] アルドステロン合成酵素の免疫組織化学による新しい副腎組織病理学2015
- Author(s)
  西本紘嗣郎、北村陽典、中川健、関次男、小坂　威雄、大家基嗣、向井邦晃
- Journal Title
  
  日本内分泌・甲状腺外科学会雑誌
  
  Volume: 32 Pages: 230-233
- NAID
  130005133176
- Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10650
[Journal Article] Identification of drug candidate against prostate cancer from the aspect of somatic cell reprogramming.2014
- Author(s)
  Kosaka T, Nagamatsu G, Saito S, Oya M, Suda T, Horimoto K
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Issue: 8 Pages: 1017-1026
- DOI
  10.1111/cas.12183
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130004, KAKENHI-PROJECT-23618011, KAKENHI-PUBLICLY-24116522, KAKENHI-PROJECT-24890230
[Journal Article] Prognostic value of preoperative multiparametric magnetic resonance imaging (MRI) for predicting biochemical recurrence after radical prostatectomy2014
- Author(s)
  Hattori S, Kosaka T, Mizuno R, Kanao K, Miyajima A, Yasumizu Y, Yazawa S, Nagata H, Kikuchi E, Mikami S, Jinzaki M, Nakagawa K, Tanimoto A, Oya M
- Journal Title
  
  BJU Int
  
  Volume: 113(5) Issue: 5 Pages: 741-7
- DOI
  10.1111/bju.12329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890230
[Journal Article] A Multi-Institutional Validation of the Prognostic Value of the Neutrophil-to-Lymphocyte Ratio for Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy.2014
- Author(s)
  Tanaka N, Kikuchi E, Kanao K, Matsumoto K, Shirotake S, Miyazaki Y, Kobayashi H, Kaneko G, Hagiwara M, Ide H, Obata J, Hoshino K, Hayakawa N, Kosaka T, Hara S, Oyama M, Momma T, Nakajima Y, Jinzaki M, Oya M
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 21(12) Issue: 12 Pages: 4041-8
- DOI
  10.1245/s10434-014-3830-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390374, KAKENHI-PROJECT-26462429
[Journal Article] Dual PI3K/mTOR inhibitor NVP-BEZ235 sensitizes docetaxel in castration resistant prostate cancer2014
- Author(s)
  Yasumizu Y, Miyajima A, Kosaka T, Miyazaki Y, Kikuchi E, Oya M
- Journal Title
  
  J Urol
  
  Volume: 191(1) Issue: 1 Pages: 227-34
- DOI
  10.1016/j.juro.2013.07.101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890230
[Journal Article] Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas.2014
- Author(s)
  Mikami S, Mizuno R, Kosaka T, Saya H, Oya M and Okada Y
- Journal Title
  
  Int J Cancer
  
  Volume: 136 Issue: 7 Pages: 1504-1514
- DOI
  10.1002/ijc.29137
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390374, KAKENHI-PROJECT-25460422
[Journal Article] Invasion and metastasis of renal cell carcinoma2014
- Author(s)
  Mikami S, Oya M, Mizuno R, Kosaka T, Katsube K, Okada Y.
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460422
[Journal Article] Activation of aryl hydrocarbon receptor promotes invasion of clear cell renal cell carcinoma and is associated with poor prognosis and cigarette smoke.2014
- Author(s)
  Ishida M, Mikami S, Shinojima T, Kosaka T, Mizuno R, Kikuchi E, Miyajima A, Okada Y, Oya M
- Journal Title
  
  Int J Cancer
  
  Volume: Epub ahead of print Issue: 2 Pages: 299-310
- DOI
  10.1002/ijc.29398
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390374, KAKENHI-PROJECT-15H04977
[Journal Article] Invasion and metastasis of renal cell carcinoma.2014
- Author(s)
  Mikami S, Oya M, Mizuno R, Kosaka T, Katsube KI, Okada Y.
- Journal Title
  
  Med Mol Morphol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890230
[Journal Article] Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelialcarcinoma.2013
- Author(s)
  Shunsuke Yoshimine, Eiji Kikuchi, Takeo Kosaka, Shuji Mikami, Akira Miyajima, Yasunori Okada, Mototsugu Oya.
- Journal Title
  
  British Journal of Cancer (2013)
  
  Volume: 108 Issue: 11 Pages: 1-9
- DOI
  10.1038/bjc.2013.216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791784, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24890230
[Journal Article] Human castrationresistant prostate cancer rather prefer to decreased 5α-reductase activity.2013
- Author(s)
  Kosaka T, Miyajima A, Nagata H, Maeda T, Kikuchi E, Oya M.
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 1268-1268
- DOI
  10.1038/srep01268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591777, KAKENHI-PROJECT-24890230
[Journal Article] The prognostic significance of vasohibin-1 expression in patients with prostate cancer.2013
- Author(s)
  Kosaka T, Miyazaki Y, Miyajima A, Mikami S, Hayashi Y, Tanaka N, Nagata H, Kikuchi E, Nakagawa K, Okada Y, Sato Y, Oya M
- Journal Title
  
  Br J Cancer.
  
  Volume: 108 Issue: 10 Pages: 2123-2129
- DOI
  10.1038/bjc.2013.169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591777, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24890230
[Journal Article] Invasion and metastasis of renal cell carcinoma2013
- Author(s)
  Mikami S, Oya M, Mizuno R, Kosaka T, Katsube KI, Okada Y
- Journal Title
  
  Med Mol Morphol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890230
[Journal Article] Bisebromoamide, an extract from Lyngbya species, induces apoptosis through ERK and mTOR inhibitions in renal cancer cells2013
- Author(s)
  K. Suzuki, R. Mizuno, K. Suenaga, T. Teruya, N. Tanaka, T. Kosaka, M. Oya
- Journal Title
  
  Cancer Medicine
  
  Volume: 2 Issue: 1 Pages: 32-39
- DOI
  10.1002/cam4.53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21221009, KAKENHI-PROJECT-24390374, KAKENHI-PROJECT-24890230
[Journal Article] Patient characteristics and outcomes in metastatic upper tract urothelial carcinoma after radical nephroureterectomy: the experience of Japanese multi-institutions2013
- Author(s)
  Nobuyuki Tanaka, Eiji Kikuchi, Kent Kanao, Kazuhiro Matsumoto, Hiroaki Kobayashi, Yasumasa Miyazaki, Hiroki Ide, Jun Obata, Katsura Hoshino, Suguru Shirotake, Nozomi Hayakawa, Takeo Kosaka, Akira Miyajima, Tetsuo Momma, Ken Nakagawa, Shintaro Hasegawa, Yosuke Nakajima, Mototsugu Oya
- Journal Title
  
  British Journal of Urology
  
  Volume: 112 Issue: 2 Pages: 741-747
- DOI
  10.1111/bju.12133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791671, KAKENHI-PROJECT-24890230
[Journal Article] The prognostic significance of vasohibin-1 expression in patients with prostate cancer2013
- Author(s)
  Takeo Kosaka
- Journal Title
  
  Br J Cancer
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890230
[Journal Article] Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells.2011
- Author(s)
  Taisuke Kinoshita, Go Nagamatsu, Takeo Kosaka, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications 407(2)
  
  Pages: 321-326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791527
[Journal Article] A Germ Cell-specific Gene, Prmt5, Works in Somatic Cell Reprogramming.2011
- Author(s)
  Go Nagamatsu, Takeo Kosaka, et al.
- Journal Title
  
  The Journal of Biological Chemistry. 286(12)
  
  Pages: 321-326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791527
[Journal Article] A Germ Cell-specific Gene, Prmt5, Works in Somatic Cell Reprogramming2011
- Author(s)
  Go Nagamatsu, Takeo Kosaka, et al
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286(12) Pages: 10641-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791527
[Journal Article] Cis-dichlorodiammineplatinum upregulates angiotensin II type 1 receptors through reactive oxygen species generation and enhances VEGF production in bladder cancer.2010
- Author(s)
  Tanaka N, Miyajima A, Kosaka T, Shirotake S, Hasegawa M, Kikuchi E, Oya M.
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 9(11) Pages: 2982-2992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390445
[Journal Article] Expression of Snail in upper urinary tract urothelial carcinoma : Prognostic significance and implications for tumor invasion.2010
- Author(s)
  Kosaka T, Kikuchi E, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M
- Journal Title
  
  Clin Cancer Res
  
  Volume: 16(23) Pages: 5814-5823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390445
[Journal Article] Activation of the Aryl hydrocarbon receptor pathway enhances cancer cell invasion by up-regulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer.2010
- Author(s)
  Ishida M, Mikami S, Kikuchi E, Kosaka T, Miyajima A, Nakagawa K, Mukai M, Okada Y, Oya M
- Journal Title
  
  Carcinogenesis
  
  Volume: 31(2) Pages: 287-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390445
[Journal Article] Ets-1 and hypoxia inducible factor-lalpha inhibition by angiotensin II type-1 receptoe blockade in hormone-refractory prostate cancer2010
- Author(s)
  Kosaka T, et al
- Journal Title
  
  Prostate 70(2)
  
  Pages: 162-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390445
[Presentation] がんゲノム医療の臨床（腎がん/尿路上皮がん/前立腺がん）2023
- Author(s)
  小坂　威雄
- Organizer
  クリニカルバイオバンク学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03817
[Presentation] バイオインフォマティクスを用いたカバジタキセル耐性前立腺癌リプログラミング薬剤のスクリーニング2022
- Author(s)
  本郷周, 小坂威雄, 安水洋太, 田中伸之, 武田利和, 森田伸也, 松本一宏, 水野隆一, 大家基嗣
- Organizer
  前立腺シンポジウム　2022年
- Invited
- Data Source
  KAKENHI-PROJECT-20H03817
[Presentation] ゲノム医療の臨床（腎がん　尿路上皮がん　前立腺がん）2022
- Author(s)
  小坂　威雄
- Organizer
  クリニカルバイオバンク学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19579
[Presentation] 「Think different in mCSPC treatment strategies!」前立腺癌の臨床的・生物学的特徴から考えるmHNPC転移性前立腺癌に対する個別化医療2022
- Author(s)
  小坂　威雄
- Organizer
  第87回日本泌尿器科学会東部総会シンポジウム1
- Invited
- Data Source
  KAKENHI-PROJECT-20H03817
[Presentation] 前立腺がん細胞の低酸素環境における細胞遊走-増殖ダイコトミーに関わるO-結合型糖鎖の解析2022
- Author(s)
  山本大樹, 小坂威雄, 大家基嗣, 佐藤智典
- Organizer
  第81回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-21K19579
[Presentation] バイオインフォマティクスを用いたカバジタキセル耐性前立腺癌リプログラミング薬剤のスクリーニング2022
- Author(s)
  本郷周, 小坂威雄, 安水洋太, 田中伸之, 武田利和, 森田伸也, 松本一宏, 水野隆一, 大家基嗣
- Organizer
  前立腺シンポジウム　2022年
- Invited
- Data Source
  KAKENHI-PROJECT-21K19579
[Presentation] 前立腺がん細胞の低酸素環境における細胞遊走-増殖ダイコトミーに関わるO-結合型糖鎖の解析2022
- Author(s)
  山本大樹, 小坂威雄, 大家基嗣, 佐藤智典
- Organizer
  第81回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-20H03817
[Presentation] シンポジウム1Think different in mCSPC treatment strategies前立腺癌の臨床的生物学的特徴から考えるmHNPC転移性前立腺癌に対する個別化医療2022
- Author(s)
  小坂　威雄
- Organizer
  第87回日本泌尿器科学会東部総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19579
[Presentation] HBOC診療の課題とこれから　これからの遺伝性乳癌卵巣癌(HBOC)診療体制を再考する　慶應HBOCセンターの取り組み2022
- Author(s)
  小林佑介, 増田健太, 関朋子, 小坂威雄, 北郷実, 小野伊久美, 三須久美子, 中村康平, 内田明花, 舩越建, 竹内麻理, 小崎健次郎, 青木大輔
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03817
[Presentation] 若手臨床医が基礎研究に携わる意義と方法2021
- Author(s)
  大家基嗣、小坂威雄
- Organizer
  第80回　日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19579
[Presentation] もう知らないとは言わせないHBOC　前立腺癌2021
- Author(s)
  小坂威雄
- Organizer
  第109回日本泌尿器科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03817
[Presentation] 進行性去勢感受性前立腺癌の治療戦略：ドセタキセル2021
- Author(s)
  小坂威雄
- Organizer
  第109回日本泌尿器科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03817
[Presentation] 前立腺神経内分泌がんにおける血中循環腫瘍細胞のシングルセル解析と空間的遺伝子発現解析システムを統合した腫瘍内不均一性の解明と革新的新規治療戦略の確立2021
- Author(s)
  小坂　威雄
- Organizer
  第109回日本泌尿器科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19579
[Presentation] 前立腺癌におけるBRCA1/2遺伝学的検査と遺伝カウンセリング　遺伝性乳癌卵巣癌(HBOC)診療ガイドライン2021と前立腺癌2021
- Author(s)
  小坂　威雄
- Organizer
  第109回日本泌尿器科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19579
[Presentation] Single-cell RNA-seq analysis of intra-tumor heterogeneity dynamics reveals the novel platinum resistance gene COX7B in patients with urinary bladder cancer2020
- Author(s)
  田中伸之、丹羽直也、本郷周、安水洋太、武田利和、松本一宏、森田伸也、小坂威雄、水野隆一、浅沼宏、Per Uhlen、大家基嗣
- Organizer
  第108回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-19H03792
[Presentation] 腫瘍免疫学的分類（Immuno-clustering）による腎細胞癌の新しいサブクラス分類と臨床的有用性2020
- Author(s)
  髙松公晴, 田中伸之, 三上修治, 箱崎恭平, 髙橋遼平, 武田利和, 森田伸也, 松本一宏, 小坂威雄, 水野隆一, 浅沼宏, 垣見和宏, 大家基嗣
- Organizer
  第108回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-18H02939
[Presentation] 進行性去勢感受性前立腺癌の治療戦略：ドセタキセル2020
- Author(s)
  小坂威雄、大家基嗣
- Organizer
  第58回日本癌治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03817
[Presentation] 転移性腎癌における転移巣完全切除の臨床的効果2020
- Author(s)
  高松公晴, 水野隆一, 安水洋太, 田中伸之, 武田利和, 森田伸也, 松本一宏, 小坂威雄, 浅沼宏, 大東貴志, 大家基嗣
- Organizer
  第58回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02939
[Presentation] mCRPCの未来予想図：タキサン系抗がん剤の位置づけを再考する2020
- Author(s)
  小坂威雄
- Organizer
  第6回日本泌尿器腫瘍学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03817
[Presentation] 進行性腎細胞癌favorableリスク群における予後因子の検討2020
- Author(s)
  水野隆一, 高松公晴, 安水洋太, 田中伸之, 森田伸也, 松本一宏, 武田利和, 小坂威雄, 浅沼宏, 大家基嗣
- Organizer
  第58回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02939
[Presentation] 淡明細胞型腎細胞癌におけるAXL発現の腫瘍内不均一性と予後の検討2020
- Author(s)
  箱崎恭平, 田中伸之, 高松公晴, 安水洋太, 武田利和, 松本一宏, 森田伸也, 小坂威雄, 水野隆一, 浅沼宏, 大家基嗣
- Organizer
  第58回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02939
[Presentation] 透析患者に発生する腎細胞癌のOmics解析と腫瘍免疫微小環境の統合的理解2020
- Author(s)
  高橋遼平, 田中伸之, 宮冬樹, 鎌谷高志, 武田利和, 松本一宏, 森田伸也, 小坂威雄, 水野隆一, 三上修治, 垣見和宏, 角田達彦, 大家基嗣
- Organizer
  第108回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-18H02939
[Presentation] 淡明型腎細胞癌における三次リンパ様構造(TLS)の臨床病理学的検討2020
- Author(s)
  桝田司, 田中伸之, 箱崎恭平, 高松公晴, 安水洋太, 武田利和, 松本一宏, 森田伸也, 小坂威雄, 水野隆一, 浅沼宏, 三上修治, 大家基嗣
- Organizer
  第58回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02939
[Presentation] タキサン系抗癌剤耐性前立腺癌に対するトポイソメラーゼ阻害剤の有用性2019
- Author(s)
  本郷, 周小坂, 威雄安水, 洋太宮崎, 保匡田中, 伸之武田, 利和松本, 一宏森田, 伸也水野, 隆一大家, 基嗣
- Organizer
  57回日本癌治療学会
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] Innovative approach for cancer by advanced microscopy　Visualizing Intratumoral Heterogeneity by 3D Light Sheet Microscopy: Cell-by-Cell Protein/RNA Analysis in Intact Tumors2019
- Author(s)
  田中, 伸之三上, 修治小坂, 威雄水野, 隆一大家, 基嗣
- Organizer
  78回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] 癌幹細胞を標的としたスルファサラジン膀胱内注入治療の効果2019
- Author(s)
  荻原広一郎、菊地栄次、田中伸之、小坂威雄、佐谷秀行、大家基嗣
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K11157
[Presentation] 3次元ライトシート顕微鏡による腫瘍内不均一性の可視化：スライドフリーな1細胞レベルのタンパク/RNA発現解析2019
- Author(s)
  田中伸之、三上修治、小坂威雄、水野隆一、大家基嗣
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03792
[Presentation] 前立腺癌薬物治療のパラダイムシフト　バイオマーカーのパラダイムシフト　Precision medicineに向けて2019
- Author(s)
  小坂, 威雄大家, 基嗣
- Organizer
  107回日本泌尿器科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] 3次元ライトシート顕微鏡を用いた次世代泌尿器癌イメージング:腫瘍内不均一性の可視化2019
- Author(s)
  田中伸之、三上修治、桝田司、武田利和、松本一宏、森田伸也、小坂威雄、浅沼宏、水野隆一、大家基嗣
- Organizer
  第57回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03792
[Presentation] ゲムシタビン耐性膀胱癌は癌蛋白MUC1Cを介して、シスプラチンへの交叉耐性を獲得する2019
- Author(s)
  茂田, 啓介菊地, 栄次長谷川, 政徳荻原, 広一郎小坂, 威雄水野, 隆一宮嶋, 哲大家, 基嗣
- Organizer
  107回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] Prognostic value of serum C-reactive protein level prior to second-line treatment in intermediate risk metastatic renal cell carcinoma patients.2019
- Author(s)
  Takamatsu K, Mizuno R, Hayakawa N, Kikuchi E, Kosaka T, Oya M
- Organizer
  ASCO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02939
[Presentation] G2/M期制御因子を標的としたカバジタキセル耐性前立腺癌克服薬剤のIn silico screening2019
- Author(s)
  本郷, 周小坂, 威雄楊井, 祥典安水, 洋太宮崎, 保匡水野, 隆一菊地, 栄次大家, 基嗣
- Organizer
  107回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] Efficacy of systemic therapy for metastatic renal cell carcinoma in patients over 75 years of age.2019
- Author(s)
  Mizuno R, Takamatsu K, Hayakawa N, Kosaka T, Tanaka N, Oya M
- Organizer
  ASCO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02939
[Presentation] Network Medicine to Overcome Drug Resistance in CRPC or NEPC: Drug Efficacy Reprogramming2018
- Author(s)
  小坂威雄
- Organizer
  第106回日本泌尿器科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] Constitutive activation of mTOR pathways in renal cell carcinoma arising in dialyzed patients.2018
- Author(s)
  Mizuno R, Mikami S, Takamatsu K, Hayakawa N, Kosaka T, Kikuchi E, Oya M
- Organizer
  ASCO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02939
[Presentation] In silico screening using RNA-seq data sets of Neuroendocrine prostate cancer has identified candidate drugs for reprogramming NEPC-specific signatures2018
- Author(s)
  Kosaka T, Hongo H, Mikami S, Matsumoto K, Kikuchi E, Oya M:
- Organizer
  AUA Annual Meeting　San Francisco: 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] The clinical impact of serum C-reactive protein levels in metastatic renal-cell carcinoma patients treated by second-line molecular targeted therapies.2018
- Author(s)
  Takamatsu K, Mizuno R, Hayakawa N, Kosaka T, Kikuchi E, Mikami S, Oya M
- Organizer
  ASCO Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02939
[Presentation] CRPC に対する抗がん化学療法の現況と課題：リアルワールドデータから考察する2018
- Author(s)
  小坂威雄
- Organizer
  日本泌尿器腫瘍学会第4回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] 前立腺癌のリキッドバイオプシー（血液循環腫瘍細胞：CTC）の現状と課題2018
- Author(s)
  小坂威雄、本郷周、大家基嗣
- Organizer
  第56回日本癌治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] Imaging mass spectrometry co-accumlation and 18-oxocortisol with CYP11B2 in pre-adenomatous states of primary aldosteronism2018
- Author(s)
  Yuki Sugiura, Emi Takeo, Shuichi Shimma, Mai Yokota, Tatsuya Higashi, Tsugio Seki, Mototsugu Oya, Takeo Kosaka, Tetsuo Nishikawa, Koshiro Nishimoto, Motoko Suematsu
- Organizer
  AUA2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10650
[Presentation] Aldosterone specific visualization in primary aldosteronism using imaging mass spectrometry2018
- Author(s)
  Shuichi Shimma, Emi Takeo, Koshiro Nishimoto, Eiichiro Fukusaki, Yuki Sugiura
- Organizer
  XXII International Mass Spectrometry Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10650
[Presentation] MALDIイメージングから視えてきたアルドステロン(aldo)産生病変の進展様式2018
- Author(s)
  西本紘嗣郎, 杉浦悠毅, 竹尾映美, 新間秀一, 東達也, 西川哲男, 小坂威雄, 大家基嗣, 末松誠
- Organizer
  第106回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-15K10650
[Presentation] Roles of topoisomerase inhibitors and cisplatin for CRPC in the post-cabazitaxel setting2018
- Author(s)
  Kosaka T, Hongo H, Yasumizu Y, Miyazaki Y, Kikuchi E, Oya M
- Organizer
  AUA Annual Meeting　San Francisco: 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] 転移性腎細胞癌に対するニボルマブの効果予測因子の検討2018
- Author(s)
  高松公晴, 水野隆一, 田中伸之, 武田利和, 森田伸也, 松本一宏, 小坂威雄, 篠島利明, 菊地栄次, 浅沼宏, 三上修治, 大家基嗣
- Organizer
  第56回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08657
[Presentation] 上部尿路上皮癌におけるPD-1発現の臨床的検討2017
- Author(s)
  弓削和之, 菊地栄次, 早川望, 福本桂資郎, 小坂威雄, 三上修治, 宮嶋哲, 飯沼誠一, 大家基嗣
- Organizer
  日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-16K08657
[Presentation] 尿路上皮癌細胞における糖尿病治療薬メトホルミンを用いた CD44v 制御2017
- Author(s)
  萩原正幸、菊地栄次、小坂威雄、宮嶋哲、中川健、佐谷秀行
- Organizer
  第105回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-17K11157
[Presentation] 前立腺癌における予後因子としてのバソヒビン2発現の検討2017
- Author(s)
  宮崎保匡, 小坂威雄, 三上修治, 安水洋太, 田中伸之, 菊地栄次, 佐藤靖史, 大家基嗣
- Organizer
  日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16K08657
[Presentation] 有効性と安全性の狭間から見えてきたカバジタキセル使用の実際2017
- Author(s)
  小坂威雄、篠島利明、森田伸也、大家基嗣
- Organizer
  第82回日本泌尿器科学会東部総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] 前立腺癌におけるLiquid Biopsyの現状と課題2017
- Author(s)
  小坂威雄、大家基嗣
- Organizer
  第82回日本泌尿器科学会東部総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] ニボルマブ関連間質性肺炎に対してステロイドが有効であった転移性腎細胞癌の1例2017
- Author(s)
  岩佐俊、水野隆一、寺西悠、森田伸也、篠田和伸、小坂威雄、篠島利明、菊地栄次、浅沼宏、秋田大宇、陣崎雅弘、額賀重成、大家基嗣
- Organizer
  第82回日本泌尿器科学会東部総会
- Data Source
  KAKENHI-PROJECT-15H04977
[Presentation] BCL6を標的としたエンザルタミド耐性去勢抵抗性前立腺癌克服戦略2017
- Author(s)
  本郷周、小坂威雄、宮崎保匡、菊地栄次、大家基嗣
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] Visualization of aldosteronerelated steroids on adrenal frozen sections.2017
- Author(s)
  Nishimoto K, Higashi T, Nishikawa T, Seki T, Oyama M, Kosaka T, Oya M, Suematsu M, Sugiura Y.
- Organizer
  European Urology Association 2017
- Place of Presentation
  London、イギリス
- Year and Date
  2017-03-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10650
[Presentation] 血管新生阻害薬に対して初期耐性を示した進行性腎細胞癌症例の特徴2017
- Author(s)
  篠島利明、水野隆一、松本一宏、森田伸也、篠田和伸、小坂威雄、菊地栄次、浅沼宏、宮嶋哲、大家基嗣
- Organizer
  第105回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-15H04977
[Presentation] 上皮間葉移行に着目したカバジタキセル耐性去勢抵抗性前立腺癌克服戦略2017
- Author(s)
  本郷周、小坂威雄、菊地栄次、宮嶋哲、大家基嗣
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11158
[Presentation] 当院における腹腔鏡下副腎部分切除術の術式確立の試み2017
- Author(s)
  勝井政博、宮嶋哲、森田伸也、松本一宏、篠田和伸、小坂威雄、水野隆一、篠島利明、菊地栄次、浅沼宏、大家基嗣
- Organizer
  第105回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-15H04977
[Presentation] 前立腺癌のがん幹細胞性遺伝子ネットワークを標的とした薬剤耐性克服を目指す新規治療戦略2016
- Author(s)
  小坂威雄
- Organizer
  第11回ＴＲワークシップ
- Place of Presentation
  都市センターホテル（東京都千代田区）
- Year and Date
  2016-01-15
- Invited
- Data Source
  KAKENHI-PROJECT-26861299
[Presentation] 尿路上皮癌細胞におけるニコチンのPI3K/Akt/mTOR経路を介した抗癌剤耐性獲得に関わる基礎的研究2016
- Author(s)
  弓削和之、菊地栄次、荻原広一郎、福本桂資郎、萩原正幸、安水洋太、田中伸之、松本一宏、小坂威雄、宮嶋哲、大家基嗣
- Organizer
  第25回泌尿器科分子・細胞研究会
- Place of Presentation
  ハイアットリージェンシー大阪（大阪府大阪市）
- Year and Date
  2016-02-26
- Data Source
  KAKENHI-PROJECT-26462428
[Presentation] Nicotine induces aggressiveness and acquiring chemoresistance in bladder cancer cells2016
- Author(s)
  Yuge K, Kikuchi E, Ogihara K, Fukumoto K, Hagiwara M, Yasumizu Y, Tanaka N, Matsumoto K, Kosaka T, Miyajima A, Iinuma S, Oya M
- Organizer
  第104回日本泌尿器科学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-04-23
- Data Source
  KAKENHI-PROJECT-26462428
[Presentation] アルドステロン産生細胞クラスターからアルドステロン産生腺腫への移行を示唆する新規病変の同定とその体細胞遺伝子変異解析2016
- Author(s)
  西本紘嗣郎、関次男、栗原勲、横田健一、大村昌夫、西川哲男、柴田洋孝、小坂威雄、大家基嗣、末松誠、向井邦晃
- Organizer
  第3回PA・Aldosterone関連疾患研究会
- Place of Presentation
  フクラシア東京ステーション (東京都千代田区)
- Year and Date
  2016-02-06
- Data Source
  KAKENHI-PROJECT-15K10650
[Presentation] 血管新生阻害薬に対して内因性耐性を示した進行性腎細胞癌症例の転帰2016
- Author(s)
  篠島利明、水野隆一、松本一宏、森田伸也、篠田和伸、小坂威雄、菊地栄次、浅沼宏、宮嶋哲、大家基嗣
- Organizer
  第104回日本泌尿器科学会総会
- Place of Presentation
  仙台国際センター（仙台市青葉区）
- Year and Date
  2016-04-23
- Data Source
  KAKENHI-PROJECT-15H04977
[Presentation] A case report: Nodule development from subcapsular aldosterone-producing cell clusters causes hyperaldosteronism2016
- Author(s)
  Koshiro Nishimoto, Tsugio Seki, Isao Kurihara, Kenichi Yokota, Masao Omura, Tetsuo Nishikawa, Hirotaka Shibata, Takeo Kosaka, Mototsugu Oya, Makoto Suematsu, Kuniaki Mukai
- Organizer
  ENDO 2016
- Place of Presentation
  Boston (USA)
- Year and Date
  2016-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10650
[Presentation] A novel pathology related to subcapsular aldosterone-producing cell clusters causes hyperaldosteronism.2016
- Author(s)
  Koshiro Nishimoto, Tsugio Seki, Isao Kurihara, Kenichi Yokota, Masao Omura, Tetsuo Nishikawa, Hirotaka Shibata, Takeo Kosaka, Mototsugu Oya, Makoto Suematsu, Kuniaki Mukai.
- Organizer
  AUA 2016
- Place of Presentation
  San Diago、アメリカ合衆国
- Year and Date
  2016-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10650
[Presentation] POSSIBLE INVOLVEMENT OF A NOVEL INTERMEDIATE LESION BETWEEN APCC AND APA IN A PRIMARY HYPERALDOSTERONISM PATIENT2016
- Author(s)
  Minae Koga, Koshiro Nishimoto, Tsugio Seki, Kuniaki Mukai, Makoto Suematsu, Takeo Kosaka, Mototsugu Oya, Kohzoh Makita, Seishi Matsui, Yuya Tsurutani, Yoko Matsuzawa, Jun Saito, Masao Omura, Tetsuo Nishikawa
- Organizer
  Conference on the Adrenal Cortex 2016
- Place of Presentation
  Boston (USA)
- Year and Date
  2016-03-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10650
[Presentation] 加齢によるアルドステロン産生細胞クラスターの発生とヒト副腎皮質リモデリング.2016
- Author(s)
  西本紘嗣郎, 森田伸也, 小坂威雄, 大家基嗣
- Organizer
  第28回日本内分泌外科学会総会
- Place of Presentation
  横浜
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-15K10650
[Presentation] 前立腺がんの病理に基づく治療戦略低リスク前立腺癌におけるがん微小環境マーカーとしてのVasohibin-1発現の臨床的意義2016
- Author(s)
  小林裕章, 小坂威雄, 三上修治, 宮崎保匡, 松本一宏, 菊地栄次, 宮嶋哲, 亀山香織, 佐藤靖史, 大家基嗣
- Organizer
  第54回日本癌治療学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-20
- Data Source
  KAKENHI-PROJECT-16K08657
[Presentation] A Case Report: Nodule Development from Subcapsular Aldosterone-Producing Cell Clusters Causes Hyperaldosteronism.2016
- Author(s)
  Nishimoto K, Seki T, Kurihara I, Yokota K, Omura M, Nishikawa T, Shibata H, Kosaka T, Oya M, Suematsu M, Mukai K.
- Organizer
  ENDO 2016
- Place of Presentation
  Boston、アメリカ合衆国
- Year and Date
  2016-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10650
[Presentation] 前立腺癌進展の分子メカニズムと去勢抵抗性前立腺癌に対する治療戦略2015
- Author(s)
  小坂　威雄
- Organizer
  日本癌学会
- Place of Presentation
  愛知県　名古屋市　名古屋国際会議場
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-26861299
[Presentation] Plasma fibrinogen level independently predicts the prognosis of patients with non-metastatic renal cell carcinoma2015
- Author(s)
  Obata J, Tanaka N, Mizuno R, Morita S, Shinoda K, Kosaka T, Shinojima T, Kikuchi E, Asanuma H, Miyajima A, Oya M
- Organizer
  The 110th American Urological Association Annual Meeting
- Place of Presentation
  ニューオーリンズ（アメリカ）
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04977
[Presentation] 難治性前立腺癌に対する再プログラム化戦略2015
- Author(s)
  小坂　威雄
- Organizer
  第７４回日本癌学会学術集会　臓器別シンポジウム、前立腺癌進展の分子メカニズムと去勢抵抗性前立腺癌に対する治療戦略
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2015-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-26861299
[Presentation] AXL-Gas6カスケード亢進と上部尿路上皮癌術後の予後との関連2015
- Author(s)
  服部盛也、菊地栄次、小坂威雄、宮嶋哲、三上修治、大家基嗣
- Organizer
  第103回日本泌尿器科学会総会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-04-18
- Data Source
  KAKENHI-PROJECT-26462428
[Presentation] Predictors of renal dysfunction during everolimus treatment in patients with metastatic renal cell carcinoma2015
- Author(s)
  Mizuno R, Takahashi R, Shinojima T, Kosaka T, Miyajima A, Oya M
- Organizer
  2015 ASCO Annual Meeting
- Place of Presentation
  シカゴ（アメリカ）
- Year and Date
  2015-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04977
[Presentation] 常識を疑う前立腺癌の挙動2015
- Author(s)
  小坂　威雄
- Organizer
  第3回泌尿器画像診断・治療技術研究会
- Place of Presentation
  ウェスティン都ホテル京都（京都府京都市）
- Year and Date
  2015-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-26861299
[Presentation] 前立腺癌がん治療の治療個別化ストラテジー2015
- Author(s)
  小坂　威雄
- Organizer
  日本がん治療学会
- Place of Presentation
  京都府　京都市　国立京都国際会館
- Year and Date
  2015-10-30
- Invited
- Data Source
  KAKENHI-PROJECT-26861299
[Presentation] 尿路上皮癌におけるニコチン曝露がPI3K/Akt pathwayに及ぼす影響の基礎的検討2015
- Author(s)
  弓削和之、菊地栄次、安水洋太、萩原正幸、小坂威雄、宮嶋哲、飯沼誠一、大家基嗣
- Organizer
  第103回日本泌尿器科学会総会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-04-18
- Data Source
  KAKENHI-PROJECT-26462428
[Presentation] ドセタキセル療法抵抗性前立腺癌に対するリバビリン併用ドセタキセル療法に関する非盲検非無作為化前向きパイロット臨床試験2015
- Author(s)
  小坂威雄、前田高宏、長田浩彦、吉峰俊輔、篠島利明、水野隆一、篠田和伸、森田伸也、菊地栄次、宮嶋哲、大家基嗣
- Organizer
  第103回日本泌尿器科学会総会
- Place of Presentation
  ホテル日航金沢（金沢県金沢市）
- Year and Date
  2015-04-18
- Data Source
  KAKENHI-PROJECT-26861299
[Presentation] 難治性前立腺癌に対する遺伝子発現プロファイルを標的とした新規治療戦略2015
- Author(s)
  小坂　威雄
- Organizer
  第第53回日本癌治療学会学術集会　前立腺癌：前立腺癌がん治療個別化の最前線：臓器別シンポジウム　去勢抵抗性前立腺癌に対する治療戦略
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-10-30
- Invited
- Data Source
  KAKENHI-PROJECT-26861299
[Presentation] 去勢抵抗性前立腺癌におけるアンドロゲン産生系の生化学的解析2013
- Author(s)
  小坂威雄,宮嶋哲,安水洋太,菊地栄次,大家基嗣
- Organizer
  第32回アンドロロジー学会
- Place of Presentation
  大阪グランキューブ大阪
- Year and Date
  2013-07-26
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 「腎癌up to date　個別化医療をめざして」腎細胞癌における上皮-間葉転換と分子標的治療2013
- Author(s)
  三上修治, 水野隆一, 小坂威男, 大家基嗣, 岡田保典
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-25460422
[Presentation] A new strategy for castration resistant prostate cancer with targeting to feedback mechanisms of PI3K/AKT/mTOR pathway2013
- Author(s)
  5: Yasumizu Y, Miyajima A, Kosaka T, Kikuchi E, Oya M
- Organizer
  American Urological Association Annual Meeting
- Place of Presentation
  Sandiego USA
- Year and Date
  2013-05-06
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 前立腺癌における新規血管新生マーカーの発現の検討2013
- Author(s)
  小坂威雄,宮崎保匡,宮嶋哲、三上修治,安水洋太,菊地栄次,田中川健,岡田保典,佐藤靖史,大家基嗣
- Organizer
  第29回前立腺シンポジウム
- Place of Presentation
  東京品川コンベンションセンター
- Year and Date
  2013-12-14
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 去勢抵抗性前立腺癌における5α還元酵素活性の解析2013
- Author(s)
  小坂　威雄
- Organizer
  第22回　泌尿器科分子細胞研究会
- Place of Presentation
  高知
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] Intracrine dynamics of CYP17A1 activities in human castration resistant prostate cancer2013
- Author(s)
  Kosaka T, Miyajima A, Nagata H, Maeda T,Kikuchi E, Oya M
- Organizer
  American Urological Association Annual Meeting
- Place of Presentation
  Sandiego USA
- Year and Date
  2013-05-05
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] アンドロゲン産生系に着目した去勢抵抗性前立腺癌の生化学的解析2013
- Author(s)
  小坂威雄,宮嶋哲,長田浩彦、前田高宏、安水洋太,菊地栄次,大家基嗣
- Organizer
  第101回日本泌尿器科学会総会
- Place of Presentation
  札幌ロイトン札幌
- Year and Date
  2013-04-25
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 上部尿路上皮癌における新規血管新生制御因子Vasohibin-1発現の臨床的意義2013
- Author(s)
  宮崎保匡,小坂威雄,三上修治,菊地栄次,田中伸之,前田高宏,石田勝,宮嶋哲,中川健,岡田保典,佐藤靖史,大家基嗣
- Organizer
  日本癌治療学会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2013-09-14
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] アンドロゲン産生系に着目した去勢抵抗性前立腺癌の生化学的解析2013
- Author(s)
  小坂　威雄
- Organizer
  第101回　日本泌尿器科学会総会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] PI3K-mTORシグナル阻害剤は去勢抵抗性前立腺癌においてドセタキセルへの感受性を増大させる2013
- Author(s)
  安水洋太,宮嶋哲,小坂威雄,宮崎保匡、菊地栄次,大家基嗣
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 去勢抵抗性前立腺癌におけるCYP17A1活性(Direct evidence of dual CYP17A1 activities in human castration resistant prostate cancer)2012
- Author(s)
  小坂威雄,宮嶋哲,菊地栄次,大家基嗣
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌ロイトン札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 進行前立腺癌におけるアンドロゲン産生系の解析2012
- Author(s)
  小坂　威雄
- Organizer
  前立腺シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 去勢抵抗性前立腺癌に対するPI3K・mTORC1/2阻害剤とドセタキセル併用効果についての検討(Combination Therapy with PI3K-mTOR Pathway Inhibitor and Docetaxel in Castration Resistant Prostate Cancer)2012
- Author(s)
  安水洋太,宮嶋哲,小坂威雄,城武卓,菊地栄次,大家基嗣
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌ロイトン札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 上部尿路上皮癌におけるVasohibin-1の発現に関する予後因子として検討(The prognostic significance of vasohibin-1 expression in patients with upper urinary tract urothelial carcinoma)2012
- Author(s)
  宮崎保匡,小坂威雄,三上修治,菊地栄次,田中伸之,前田高宏,石田勝,宮嶋哲,中川健,岡田保典,佐藤靖史,大家基嗣
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌ロイトン札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 始原生殖細胞からの多能性幹細胞分化2011
- Author(s)
  永松剛、小坂威雄, 他3名
- Organizer
  第10回日本再生医療学会総会
- Place of Presentation
  新宿、東京
- Year and Date
  2011-03-02
- Data Source
  KAKENHI-PROJECT-21791527
[Presentation] 始原生殖細胞からの多能性幹細胞分化2011
- Author(s)
  永松剛、小坂威雄, 他3名
- Organizer
  第10回日本再生医療学会総会
- Place of Presentation
  新宿、東京
- Year and Date
  2011-03-02
- Data Source
  KAKENHI-PROJECT-21791527
[Presentation] Reprogramming primordial germ cells into pluripotent stem cells.2010
- Author(s)
  小坂威雄, 他5名
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路、兵庫
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21791527
[Presentation] ATM deficiency decreases reprogramming efficiency in iPS cells.2010
- Author(s)
  木下泰輔、永松剛、小坂威雄, 他3名
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路、兵庫
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21791527
[Presentation] Activation of the aryl hydrocarbon receptor is associated with cigarette smoke, poor prognosis and cancer cell invasion in renal cell carcinoma.2010
- Author(s)
  Ishida M., Mikami S., Kosaka T., Kono H., Kikuchi E., Nagata H., Miyajima A., Nakagawa K., Mukai M., Okada Y., Oya M.
- Organizer
  25^<th> Anniversary Congress of the European Association of Urology
- Place of Presentation
  Barcelona
- Year and Date
  2010-04-17
- Data Source
  KAKENHI-PROJECT-21390445
[Presentation] ATM deficiency decreases reprogramming efficiency in iPS cells.2010
- Author(s)
  木下泰輔、永松剛、小坂威雄, 他3名
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路、兵庫
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21791527
[Presentation] Reprogramming primordial germ cells into pluripotent stem cells without basic FGF.2010
- Author(s)
  小坂威雄, 他5名
- Organizer
  幹細胞シンポジウム
- Place of Presentation
  淡路、兵庫
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21791527
[Presentation] Reprogramming Primordial germ cells into pluripotent stem cells without basic FGF.2009
- Author(s)
  小坂威雄, 他5名
- Organizer
  幹細胞シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-05-16
- Data Source
  KAKENHI-PROJECT-21791527
[Presentation] Prospective analysis of reprogramming process in primordial germ cells.2009
- Author(s)
  小坂威雄, 他5名
- Organizer
  第7回幹細胞シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-05-16
- Data Source
  KAKENHI-PROJECT-21791527
[Presentation] 去勢抵抗性前立腺癌におけるアンドロゲン産生系の生化学的解析
- Author(s)
  小坂　威雄、宮嶋　哲、安水　洋太、菊地　栄次、大家　基嗣
- Organizer
  第32回　アンドロロジー学会
- Place of Presentation
  グランキュ－ブ大阪（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 尿路上皮癌における抗がん剤耐性克服とEMT制御
- Author(s)
  田中伸之　小坂威雄　宮﨑保匡　丹羽直也水野隆一　菊地栄次　宮嶋哲　大家基嗣
- Organizer
  第24回泌尿器科分子・細胞研究会
- Place of Presentation
  JPタワー（東京都千代田区）
- Year and Date
  2015-02-27 – 2015-02-28
- Data Source
  KAKENHI-PROJECT-26462429
[Presentation] Intracrine dynamics of CYP17A1 activities in human castration resistant prostate cancer
- Author(s)
  Kosaka T, Miyajima A, Nagata H, Maeda T, Kikuchi E, Oya M.
- Organizer
  American Urological Asociation Annual Meeting
- Place of Presentation
  Sandiego (USA)
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 抗がん剤耐性前立腺癌における、がん幹細胞関連遺伝子ネットワークを標的とした新規治療戦略
- Author(s)
  小坂　威雄、永松　剛、宮嶋　哲、三上　修治、斎藤　秀、宮崎　保匡、安水　洋太、水野　隆一、菊地　栄次、中川　健、堀本　勝久、岡田　保典、須田　年生、大家　基嗣
- Organizer
  第102回　日本泌尿器科学会総会
- Place of Presentation
  神戸国際展示場（神戸）
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] PI3K-mTORシグナル阻害剤は去勢抵抗性前立腺癌においてドセタキセルへの感受性を増大させる
- Author(s)
  安水　洋太、宮嶋　哲、小坂　威雄、宮崎　保匡、菊地　栄次、大家　基嗣
- Organizer
  第72回　日本癌学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 前立腺癌のがん幹細胞性遺伝子ネットワークを標的とした革新的新規治療戦略の確立
- Author(s)
  小坂　威雄、永松　剛、宮嶋　哲、三上　修治、斎藤　秀、宮崎　保匡、安水　洋太、水野　隆一、菊地　栄次、中川　健、堀本　勝久、岡田　保典、須田　年生、大家　基嗣
- Organizer
  第23回泌尿器科分子細胞研究会
- Place of Presentation
  ホテルメトロポリタン（山形）
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 上部尿路上皮癌における新規術予後予測因子の検索
- Author(s)
  服部盛也、菊地栄次、小坂威雄、、宮嶋哲、三上修治、大家基嗣
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26462428
[Presentation] A new strategy for castration resistant prostate cancer with targeting to feedback mechanism of PI3K/AKT/mTOR pathway
- Author(s)
  Yasumizu Y, Kosaka T, Miyajima A,Kikuchi E, Oya M.
- Organizer
  American Urological Asociation Annual Meeting
- Place of Presentation
  Sandiego (USA)
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] アンドロゲン産生系に着目した去勢抵抗性前立腺癌の生化学的解析
- Author(s)
  小坂　威雄、宮嶋　哲、長田　浩彦、前田　高宏、安水　洋太、服部　盛也、菊地　栄次、中川　健、大家　基嗣
- Organizer
  第101回　日本泌尿器科学会総会
- Place of Presentation
  ロイトン札幌（北海道）
- Data Source
  KAKENHI-PROJECT-24890230
[Presentation] 前立腺癌における新規血管新生関連マーカーの発現の検討
- Author(s)
  小坂　威雄、宮崎　保匡、宮嶋　哲、三上　修治、安水　洋太、菊地　栄次、中川　健、岡田　保典、佐藤　靖史、大家　基嗣
- Organizer
  第29回前立腺シンポジウム
- Place of Presentation
  品川コンベンションセンター（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-24890230

1. OYA Mototsugu (00213885)

# of Collaborated Projects: 8 results

# of Collaborated Products: 44 results
2. KIKUCHI Eiji (10286552)

# of Collaborated Projects: 8 results

# of Collaborated Products: 28 results
3. MIKAMI Syuuji (20338180)

# of Collaborated Projects: 7 results

# of Collaborated Products: 36 results
4. MIYAJIMA Akira (90245572)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. MIZUNO RYUICHI (60383824)

# of Collaborated Projects: 5 results

# of Collaborated Products: 33 results
6. TANAKA NOBUYUKI (60445244)

# of Collaborated Projects: 5 results

# of Collaborated Products: 19 results
7. MATSUMOTO Kazuhiro (80366153)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
8. Yasumizu Yota (40464854)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. 植田幸嗣 (10509110)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 西原広史 (50322805)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
11. Nishimoto Koshiro (00365363)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
12. Miyazaki Yasumasa (80445329)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 篠島利明 (60306777)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
14. 浅沼宏 (70245570)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
15. 本郷周 (10626675)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
16. 北野滋久 (60402682)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
17. NAKAGAWA Ken (50227740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. ISHIOKA KATSURA (80573352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Oyama Masafumi (70276351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 丹羽直也 (40626743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 沖健司 (30638995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 向井邦晃 (80229913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
23. 城武卓 (10528805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 加藤眞吾 (00370875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 荒木隆一郎 (00168006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. 武田利和 (10383829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 茂田啓介 (10649875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 渡辺貴志 (50406815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 安田浩之 (70365261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. NAGAMATSU Go

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. KATO Shingo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. HIGASHI Tatuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. YAMAZAKI Yuto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 宮島哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 21 results
35. 吉峰俊輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 須田年生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 中村康平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
38. 梅沢一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 荻島正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 佐谷秀行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 末永聖武

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 橋本茂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 久冨木原良平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 岡崎章悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 南嶋洋司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 鈴木貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 中村保宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 笹野公伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. Gomez-Sanchez Celso E

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 案納忠譜

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kosaka Takeo 小坂 威雄

TAKEO Kosaka 小坂 威雄

KOSAKA Takeo 小坂 威雄

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Elucidation of the molecular control mechanism of refractory prostate cancer that includes lineage plasticity and establishment of individualized treatment strategiesPrincipal Investigator

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Elucidation of tumor development mechanism by immune escape mechanism through metabolic reprogramming of anticancer drug-resistant cancerPrincipal Investigator

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Single-cell analysis of neuroendocrine prostate cancer to elucidate pathophysiology and establish novel treatment strategyPrincipal Investigator

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Integrated analysis of ITH in drug resistant prostate cancer by single cell analysisPrincipal Investigator

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Kosaka Takeo 小坂威雄

TAKEO Kosaka 小坂威雄

KOSAKA Takeo 小坂威雄