HONDA Tomoyuki 本田朋之

Researcher Number	30447635
Affiliation (based on the past Project Information) *help	2011 – 2015: 新潟大学, 医歯学総合病院, 医員 2008 – 2010: Niigata University, 医歯学系, 特任助教 2007: Niigata University, 医歯学総合病院, 医員
Review Section/Research Field	Principal Investigator Periodontal dentistry / Periodontology Except Principal Investigator Periodontology / Periodontal dentistry
Keywords	Principal Investigator Porphyromonas gingivalis / Lipopolysaccharide / 歯周病原細菌 / 小胞体ストレス / 歯周炎 / TNF-α / 炎症性サイトカイン / IL-17A / IL-17R / IL-17 … More / 歯肉上皮細胞 / 免疫回避 / miR-146a / microRNA / LPS / Toll-like receptor / マクロファージ / IRAK-M … More Except Principal Investigator 内毒素血症 / 腸内細菌 / Porphyromonas gingivalis / ペリオドンタルメディスン / メタボリックシンドローム / Porhyromonas gingivalis / 腸内細菌叢 / 全身疾患 / 歯周病 / XBP-1 / CHOP / ATF-4 / BiP / porphyromonas gingivalis / マウス実験的歯周炎 / 加齢 / 小胞体ストレス / 歯周炎 / 歯周免疫機能学 Less

小胞体ストレスを介した歯周組織破壊機構の分子基盤解明Principal Investigator
- Principal Investigator
  
  本田朋之
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
New hypothesis for the pathogenesis of periodontal medicine
- Principal Investigator
  
  YAMAZAKI Kazuhisa
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
Establishment of the new concept "pathogenic mechanism of periodontal disease by the induction of senescence of the tissues".
- Principal Investigator
  
  YAMAZAKI Kazuhisa
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
The role of interactions between IL-17 and periodontopathic bacteria in the pathogenesis of periodontitisPrincipal Investigator
- Principal Investigator
  
  HONDA Tomoyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
Elucidation of immune escape mechanisms by periodontopathic bacteriaPrincipal Investigator
- Principal Investigator
  
  HONDA Tomoyuki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
Elucidation of immune escape mechanisms by periodontopathic bacteriaPrincipal Investigator
- Principal Investigator
  
  HONDA Tomoyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University

All 2015 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Endoplasmic reticulum stress response and bone loss in experimental periodontitis in mice．2015
- Author(s)
  Yamada H, Nakajima T, Domon H, Honda T, Yamazaki K
- Journal Title
  
  J Periodontal Res.
  
  Volume: 未定 Issue: 4 Pages: 1-1
- DOI
  10.1111/jre.12232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25463216, KAKENHI-PROJECT-25670882, KAKENHI-PROJECT-26463131, KAKENHI-PROJECT-26861570
[Journal Article] Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis2012
- Author(s)
  Miyashita H., et. al.
- Journal Title
  
  Arch Oral Biol
  
  Volume: (in press) Issue: 6 Pages: 820-829
- DOI
  10.1016/j.archoralbio.2011.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390555, KAKENHI-PROJECT-23390476, KAKENHI-PROJECT-23792470
[Journal Article] Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration2012
- Author(s)
  宮沢、土門, ら
- Journal Title
  
  Clin Chim Acta
  
  Volume: 413 Issue: 1-2 Pages: 154-159
- DOI
  10.1016/j.cca.2011.09.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J01295, KAKENHI-PROJECT-23390476, KAKENHI-PROJECT-23659974, KAKENHI-PROJECT-23792469, KAKENHI-PROJECT-23792470
[Journal Article] The effects of systemic sitafloxacin on periodontal infection control in elderly patients2012
- Author(s)
  Nakajima T, Ito H, Yamazaki K, 他5名
- Journal Title
  
  Gerodontology
  
  Volume: (in press) Issue: 2 Pages: 1024-32
- DOI
  10.1111/j.1741-2358.2011.00605.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390555, KAKENHI-PROJECT-23659974, KAKENHI-PROJECT-23792469
[Journal Article] The presence of IL-17^+/FOXP3^+ double-positive cells in periodontitis2012
- Author(s)
  Okui T, Aoki Y, Ito H, Honda T, Yamazaki K
- Journal Title
  
  J Dent Res
  
  Volume: 91(6) Issue: 6 Pages: 574-579
- DOI
  10.1177/0022034512446341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390476, KAKENHI-PROJECT-23792469, KAKENHI-PROJECT-23792470
[Journal Article] Porphyromonas gingivalis lipopolysaccharide induces miR-146a without altering the production of inflammatory cytokines.2012
- Author(s)
  Tomoyuk Honda
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 420 Issue: 4 Pages: 918-925
- DOI
  10.1016/j.bbrc.2012.03.102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659974, KAKENHI-PROJECT-23792470
[Journal Article] Increased expression of C-reactive protein gene in inflamed gingival tissues could be derived from endothelial cells stimulated with interleukin-62011
- Author(s)
  Maekawa T., et al.
- Journal Title
  
  Arch Oral Biol
  
  Volume: 56(11) Issue: 11 Pages: 1312-1318
- DOI
  10.1016/j.archoralbio.2011.04.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390555, KAKENHI-PROJECT-23390476, KAKENHI-PROJECT-23659974
[Journal Article] Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the up-regulation of early growth response-1 transcription in human coronary artery endothelial cells.2010
- Author(s)
  Maekawa T, Takahashi N, Honda T, Yonezawa D, Miyashita H, Okui T, Tabeta K, Yamazaki K.
- Journal Title
  
  J Vasc Res. 47(4)
  
  Pages: 346-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792112
[Journal Article] Periodontitis associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease.2010
- Author(s)
  Nakajima T, Honda T, Domon H, Okui T, Kajita K, Ito H, Takahashi N, Maekawa T, Tabeta K, Yamazaki K.
- Journal Title
  
  J Periodont Res. 45(1)
  
  Pages: 116-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792112
[Journal Article] Periodontitis associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease.2010
- Author(s)
  Nakajima T, Honda T, et al.
- Journal Title
  
  J Periodont Res 46
  
  Pages: 116-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792112
[Journal Article] IL-1 receptor-associated kinase-M in gingival epithelial cells attenuates the inflammatory response elicited by Porphyromonas gingivalis.2010
- Author(s)
  Takahashi N, Honda T, Domon H, Nakajima T, Tabeta K, Yamazaki K.
- Journal Title
  
  J Periodont Res. 45(4)
  
  Pages: 512-519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792112
[Journal Article] IL-1 receptor-associated kinase-M in gingival epithelial cells attenuates the inflammatory response elicited by Porphyromonas gingivalis.2010
- Author(s)
  Takahashi N, Honda T, et al.
- Journal Title
  
  J Periodont Res
  
  Volume: 45 Pages: 512-519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792112
[Journal Article] Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the up-regulation of early growth response-1 transcription in human coronary artery endothelial cells.2009
- Author(s)
  Maekawa T, Takahashi N, Honda T, et al.
- Journal Title
  
  J Vasc Res 47
  
  Pages: 346-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792112
[Journal Article] Up-regulation of the endoplasmic reticulum stress-response in periodontal disease2009
- Author(s)
  Domon H, Takahashi N, Honda T, Nakajima T, Tabeta K, Abiko Y, Yamazaki K
- Journal Title
  
  Clin Chim Acta 40
  
  Pages: 134-140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791610
[Journal Article] Early and preferential induction of IL-1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis2008
- Author(s)
  Domon H., Honda T., Oda T., Yoshie H., Yamazaki K.
- Journal Title
  
  Journal of Leukocyte Biology 83
  
  Pages: 672-679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791610
[Journal Article] Early and preferential induction of IL-1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis2008
- Author(s)
  Domon H, Honda T, Oda T, Yoshie H, Yamazaki K
- Journal Title
  
  J Leukoc Biol 83
  
  Pages: 672-679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791610
[Journal Article] Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease2008
- Author(s)
  Honda T, Aoki Y, Takahashi N, Maekawa T, Nakajima T, Ito H, Tabeta K, Okui T, Kajita K, Domon H, Yamazaki K
- Journal Title
  
  Clin Chim Acta 395
  
  Pages: 137-141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791610
[Journal Article] Elevated expression of IL-17 and IL-12 genes in chronic inflamm atory periodontal disease2008
- Author(s)
  Honda T, et.al.
- Journal Title
  
  Clinica chimica acta 395
  
  Pages: 137-141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791610
[Presentation] Periostin up-regulated by Th2 cytokines promotes periodontal inflammation2013
- Author(s)
  Honda T, Miyauchi S, Ozawa M, Murakami S, Yamazaki K
- Organizer
  91st General Session & Exhibition of the IADR
- Place of Presentation
  Seattle, USA
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-23792470
[Presentation] Periostin Up-regulated by Th2 Cytokines Promotes Periodontal Inflammation2013
- Author(s)
  Tomoyuki Honda
- Organizer
  IADR General Session and Exhibition
- Place of Presentation
  Washington State Convention Center
- Data Source
  KAKENHI-PROJECT-23792470
[Presentation] Porphyromonas gingivalis LPSがmicroRNA発現に及ぼす影響2011
- Author(s)
  本田朋之
- Organizer
  第135回日本歯科保存学会2011年度秋季学術大会
- Place of Presentation
  大阪国際交流センター（大阪府）
- Data Source
  KAKENHI-PROJECT-23792470
[Presentation] Porphyromonas gingivalis LPS が microRNA 発現に及ぼす影響2011
- Author(s)
  本田朋之,高橋直紀,宮内小百合,奥井隆文,多部田康一,中島貴子,山崎和久
- Organizer
  第135回日本歯科保存学会2011年度秋季学術大会
- Place of Presentation
  大阪
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-23792470
[Presentation] Porphyromonas gingivalis LPS がmicroRNA発現に及ぼす影響2010
- Author(s)
  本田朋之, 高橋直樹, 奥井桂子, 奥井隆文, 中島貴子, 多部田康一, 山崎和久
- Organizer
  第53回秋季日本歯周病学会学術大会
- Place of Presentation
  高松市
- Year and Date
  2010-09-19
- Data Source
  KAKENHI-PROJECT-21792112
[Presentation] bFGFがヒト歯根膜細胞のmicroRNA 発現に及ぼす影響2010
- Author(s)
  奥井桂子, 本田朋之, 奥井隆文, 高橋直紀, 土門久哲, 宮内小百合, 山崎和久
- Organizer
  第133回日本歯科保存学会2010年度秋季学術大会
- Place of Presentation
  岐阜市
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-21792112
[Presentation] Porphyromonas gingivalis LPSがmicroRNA発現に及ぼす影響2010
- Author(s)
  本田朋之, ら
- Organizer
  第53回秋季日本歯周病学会学術大会
- Place of Presentation
  サンポートホール高松(香川県)
- Year and Date
  2010-09-19
- Data Source
  KAKENHI-PROJECT-21792112
[Presentation] Periodontal treatment improves arterial stiffness.2010
- Author(s)
  Nakajima T, Honda T, Okui T, Kajita K,Domon H, Takahashi N, Maekawa T, TabetaK, Yamazaki K.
- Organizer
  AAP 2010 Annual Meeting in Honolulu
- Year and Date
  2010-11-01
- Data Source
  KAKENHI-PROJECT-21792112
[Presentation] ヒト歯肉上皮細胞のケモカイン産生におけるinterleukin (IL)-17の関与-IL-17受容体の発現とその機能解析-2010
- Author(s)
  高橋直紀, 前川知樹, 奥井隆文, 本田朋之, 多部田康一, 中島貴子, 山崎和久
- Organizer
  第53回春季日本歯周病学会学術大会
- Place of Presentation
  盛岡市
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21792112
[Presentation] Porphyromonas gingivalis modulates chemokine expression in gingival epithelial cells.2009
- Author(s)
  Takahashi N, Honda T, Tabeta K, YamazakiK.
- Organizer
  87th General session of the IADR
- Place of Presentation
  Miami
- Year and Date
  2009-04-02
- Data Source
  KAKENHI-PROJECT-21792112
[Presentation] 歯周炎患者におけるPorphyromonas gingivalisに対する抗体価と高感度CRPの関連性2009
- Author(s)
  宮下博孝, 米澤大輔, 本田朋之, 奥井隆文, 梶田桂子, 前川知樹, 高橋直紀, 伊藤晴江, 中島貴子, 多部田康一, 山崎和久
- Organizer
  第52回秋季日本歯周病学会学術大会
- Place of Presentation
  宮崎
- Year and Date
  2009-10-11
- Data Source
  KAKENHI-PROJECT-21792112
[Presentation] Porphyromonas gingivalis modulates chemokine expression in gingival epithelial cells.2009
- Author(s)
  Takahashi N, Honda T, et al.
- Organizer
  87^<th> General session of the IADR
- Place of Presentation
  Miami, FL, USA
- Year and Date
  2009-04-02
- Data Source
  KAKENHI-PROJECT-21792112
[Presentation] Antibody levels to Porphyromonas gingivalis and CRP in periodontitis patients.2009
- Author(s)
  Miyashita H, Honda T, Okui T,Kajita-Okui K, Maekawa T, TakahashiN,Ito H, Nakajima T, Tabeta K, Yamazaki K.
- Organizer
  2nd Meeting of the IADR Pan Asian Pacific Federation.
- Place of Presentation
  Wuhan
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-21792112
[Presentation] Porphyromonas gingivalis 抗原およびIL-6刺激は血管内皮細胞において転写因子Egr-1を介してMCP-1の産生を増強する2009
- Author(s)
  前川知樹, 高橋直紀, 本田朋之, 宮下博孝, 米澤大輔, 奥井隆文, 多部田康一, 山崎和久
- Organizer
  第131回日本歯科保存学会2009年度秋季学術大会
- Place of Presentation
  仙台市
- Year and Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-21792112
[Presentation] ヒト歯肉上皮細胞のケモカイン産生におけるIRAK-Mの関与2008
- Author(s)
  高橋直紀, 本田朋之, ら
- Organizer
  第51回秋季日本歯周病学会学術大会
- Place of Presentation
  三重県四日市市
- Year and Date
  2008-10-19
- Data Source
  KAKENHI-PROJECT-19791610
[Presentation] ヒト歯肉上皮細胞のケモカイン産生におけるIRAK-M の関与2008
- Author(s)
  高橋直紀,本田朋之,奥井隆文,土門久哲,吉江弘正,多部田康一,山崎和久
- Organizer
  第51回秋季日本歯周病学会学術大会
- Place of Presentation
  四日市市
- Year and Date
  2008-10-19
- Data Source
  KAKENHI-PROJECT-19791610
[Presentation] Differential induction of interleukin-1 receptor-associated kinase-M in THP-1 cells by lipopolysaccharide derived from porphyromonas gingivalis2007
- Author(s)
  Domon H., Honda T., Oda T., Yamazaki K.
- Organizer
  13th International congress of mucosal immunology
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2007-07-11
- Data Source
  KAKENHI-PROJECT-19791610
[Presentation] Differential induction of interleukin-1 receptor-associated kinase-M in THP-1 cells by lipopolysaccharide derived from Porphyromonas gingivalis2007
- Author(s)
  Domon H, Honda T, Oda T, Yamazaki K
- Organizer
  13th International congress of mucosal immunology
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2007-07-11
- Data Source
  KAKENHI-PROJECT-19791610
[Presentation] ER stress response and bone loss in experimental periodontitis mouse model.
- Author(s)
  Yamada H, Nakajima T, Domon H, Honda T, Yamazaki K.
- Organizer
  第62回JADR総会・学術大会
- Place of Presentation
  KKRホテル大阪（大阪市）
- Year and Date
  2014-12-04 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-26463131

1. TAKAHASHI Naoki

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
2. YAMAZAKI Kazuhisa (00182478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. NAKAMURA Shota (90432434)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OKUI Takafumi

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. DOMON Hisanori

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. KAJITA Keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. MIYAUCHI Sayuri

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. YAMADA Hitomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中島貴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 伊藤晴江

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HONDA Tomoyuki 本田 朋之

Research Projects

Research Products

Co-Researchers

小胞体ストレスを介した歯周組織破壊機構の分子基盤解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New hypothesis for the pathogenesis of periodontal medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of the new concept "pathogenic mechanism of periodontal disease by the induction of senescence of the tissues".

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of interactions between IL-17 and periodontopathic bacteria in the pathogenesis of periodontitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of immune escape mechanisms by periodontopathic bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of immune escape mechanisms by periodontopathic bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Endoplasmic reticulum stress response and bone loss in experimental periodontitis in mice．2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effects of systemic sitafloxacin on periodontal infection control in elderly patients2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The presence of IL-17^+/FOXP3^+ double-positive cells in periodontitis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Porphyromonas gingivalis lipopolysaccharide induces miR-146a without altering the production of inflammatory cytokines.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased expression of C-reactive protein gene in inflamed gingival tissues could be derived from endothelial cells stimulated with interleukin-62011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the up-regulation of early growth response-1 transcription in human coronary artery endothelial cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Periodontitis associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease.2010

HONDA Tomoyuki 本田朋之