Kobayashi Ken 小林謙

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KOBAYASHI KEN 小林謙

KOBAYASHI Ken 小林謙

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Researcher Number	30449003
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 農学研究院, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 北海道大学, 農学研究院, 准教授 2016: 北海道大学, 農学研究院, 准教授 2015: 北海道大学, (連合)農学研究科(研究院), 准教授 2012 – 2014: 北海道大学, (連合)農学研究科(研究院), 助教 2010: 北海道大学, 大学院・農学研究院, 助教 2010: Keio University, 大学院・農学研究院, 助教 2008 – 2009: Keio University, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 42010:Animal production science-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Integrative animal science / Basic veterinary science/Basic zootechnical science / General physiology Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator 乳腺上皮細胞 / タイトジャンクション / TRPチャネル / 乳分泌 / 乳産生 / 泌乳期 / 乳腺 / 乳腺発達 / 形態形成 / 温度受容体 … More / 乳成分 / 乳房炎 / 乳汁 / クローディン / 血液 / 灌流培養 / 乳タンパク質 / 乳糖 / 乳脂質 / 培養乳 / 物理化学的刺激 / 機械刺激受容体 / 物理的刺激 / ライブイメージング / 黄色ブドウ球菌 / 細胞内寄生 / 熱ショックタンパク質 / 乳分泌培養モデル / 寒冷ストレス / 暑熱ストレス / 血液乳関門 / ヒートショックプロテイン / TRP チャネル / 乳腺胞上皮細胞 / blood-milk barrier / TRPV4 / TRPM8 / コルチコイド / リポ多糖 / バリア / プロラクチン / 泌乳 / ミルク / クローデイン / 上皮層 / 分娩 / 早産 / 絨毛膜羊膜炎 / 傍細胞経路 / 羊水 / 羊膜 … More Except Principal Investigator 再生医療 / 移植 / 多分化能 / 脂肪組織由来細胞 Less

物理的刺激を起点として乳腺上皮細胞の乳分泌を調節する機構の解明Principal Investigator
- Principal Investigator
  
  小林謙
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Hokkaido University
血流と搾乳を模した2系統の灌流培養システムを基盤とする培養乳生産技術の開発Principal Investigator
- Principal Investigator
  
  小林謙
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Hokkaido University
Staphylococcus aureus parasitizes mammary epithelial cells to weaken the infection defense barrier.Principal Investigator
- Principal Investigator
  
  Kobayashi Ken
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Hokkaido University
物理化学的刺激を感知するTRPチャネルが乳腺組織の形態形成と乳分泌を制御する機構Principal Investigator
- Principal Investigator
  
  小林謙
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Hokkaido University
temperature-responsive molecules in mammary epithelial cells regulate the morphogenesis and functional expression of mammary epithelial cells.Principal Investigator
- Principal Investigator
  
  Kobayashi Ken
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Hokkaido University
Regulatory mechanism of milk secretion by temperature-sensitive TRP channelsPrincipal Investigator
- Principal Investigator
  
  Kobayashi Ken
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrative animal science
- Research Institution
  Hokkaido University
Influence of tight junctions on milk secretion ability in lactating mammary alveolar epithelial cellsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI KEN
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Hokkaido University
Development of collection process and implant procedure of freshly isolated adipose-derived stromal vascular fraction cells (SVF) in the operation.
- Principal Investigator
  
  SUZUKI Teruhisa
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Fukushima Medical University
The regulatory mechanism of claudins for paracellular pathway of the human amniotic epithelium.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Ken
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2017 2016 2015 2014 2013 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Effects of hydrostatic compression on milk production-related signaling pathways in mouse mammary epithelial cells2023
- Author(s)
  Kobayashi Ken、Han Liang、Lu Shan-Ni、Ninomiya Kazuki、Isobe Naoki、Nishimura Takanori
- Journal Title
  
  Experimental Cell Research
  
  Volume: 431 Issue: 1 Pages: 113762-113762
- DOI
  10.1016/j.yexcr.2023.113762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18070, KAKENHI-PROJECT-23K21258
[Journal Article] Potential effects of gingerol topical application on components of the innate immunity in lactating goat mammary glands2023
- Author(s)
  Tsugami Yusaku、Nii Takahiro、Kobayashi Ken、Isobe Naoki
- Journal Title
  
  Innate Immunity
  
  Volume: 29 Issue: 7 Pages: 135-149
- DOI
  10.1177/17534259231191252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05893, KAKENHI-PROJECT-23K21258
[Journal Article] Culture Models to Investigate Mechanisms of Milk Production and Blood-Milk Barrier in Mammary Epithelial Cells: a Review and a Protocol2023
- Author(s)
  Kobayashi Ken
- Journal Title
  
  Journal of Mammary Gland Biology and Neoplasia
  
  Volume: 28 Issue: 1 Pages: 1-14
- DOI
  10.1007/s10911-023-09536-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18070, KAKENHI-PROJECT-23K21258
[Journal Article] Sweet taste receptor subunit T1R3 regulates casein secretion and phosphorylation of STAT5 in mammary epithelial cells2023
- Author(s)
  Kobayashi Ken、Han Liang、Koyama Taku、Lu Shan-Ni、Nishimura Takanori
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1870 Issue: 4 Pages: 119448-119448
- DOI
  10.1016/j.bbamcr.2023.119448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21258
[Journal Article] Menthol application on healthy and inflamed goat udders changes antimicrobial components in milk.2023
- Author(s)
  Ohno R, Suzuki N, Tsugami Y, Nii T, Kobayashi K, Isobe N
- Journal Title
  
  Animal Science Journal
  
  Volume: 94(1) Issue: 1 Pages: 1-10
- DOI
  10.1111/asj.13832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05893, KAKENHI-PROJECT-23K21258
[Journal Article] Isoflavones and their metabolites influence the milk production ability of bovine mammary epithelial cells in a type-specific manner2022
- Author(s)
  Tsugami Y, Wakasa H, Kawahara M, Nishimura T, Kobayashi K.
- Journal Title
  
  Animal science journal
  
  Volume: 93 Issue: 1
- DOI
  10.1111/asj.13720
- Data Source
  KAKENHI-PROJECT-23K21258
[Journal Article] Lactose on the basolateral side of mammary epithelial cells inhibits milk production concomitantly with signal transducer and activator of transcription 5 inactivation2022
- Author(s)
  Kobayashi Ken、Wakasa Haruka、Han Liang、Koyama Taku、Tsugami Yusaku、Nishimura Takanori
- Journal Title
  
  Cell and Tissue Research
  
  Volume: 389 Issue: 3 Pages: 501-515
- DOI
  10.1007/s00441-022-03651-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21258
[Journal Article] Adverse Effects of High Temperature On Mammary Alveolar Development In Vitro2022
- Author(s)
  Wakasa Haruka、Tsugami Yusaku、Koyama Taku、Han Liang、Nishimura Takanori、Isobe Naoki、Kobayashi Ken
- Journal Title
  
  Journal of mammary gland biology and neoplasia
  
  Volume: 27 Issue: 2 Pages: 155-170
- DOI
  10.1007/s10911-022-09518-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21258
[Journal Article] Early effects of lipoteichoic acid from Staphylococcus aureus on milk production-related signaling pathways in mouse mammary epithelial cells2022
- Author(s)
  Kobayashi Ken、Omatsu Naoki、Han Liang、Shan-Ni Lu、Nishimura Takanori
- Journal Title
  
  Experimental Cell Research
  
  Volume: 420 Issue: 1 Pages: 113352-113352
- DOI
  10.1016/j.yexcr.2022.113352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19174
[Journal Article] Lipopolysaccharide and lipoteichoic acid influence milk production ability via different early responses in bovine mammary epithelial cells.2021
- Author(s)
  Tsugami Y, Wakasa H, Kawahara M, Nishimura T, Kobayashi K
- Journal Title
  
  Experimental cell Research
  
  Volume: 15 Issue: 2 Pages: 112472-112472
- DOI
  10.1016/j.yexcr.2021.112472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02320, KAKENHI-PROJECT-18H02321, KAKENHI-PROJECT-19J10189
[Journal Article] IL-1β is a key inflammatory cytokine that weakens lactation-specific tight junctions of mammary epithelial cells2021
- Author(s)
  Kobayashi K, Matsunaga K, Tsugami Y, Wakasa H, Nishimura T.
- Journal Title
  
  Experimental Cell Research
  
  Volume: 409 Issue: 2 Pages: 112938-112938
- DOI
  10.1016/j.yexcr.2021.112938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19174
[Journal Article] Local heat treatment of goat udders influences innate immune functions in mammary glands2021
- Author(s)
  Tsugami Y, Ishiba Y, Suzuki N, Nii T, Kobayashi K, Isobe N
- Journal Title
  
  Journal of Mammary Gland Biology and Neoplasia
  
  Volume: 26 Issue: 4 Pages: 387-397
- DOI
  10.1007/s10911-022-09509-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05893, KAKENHI-PROJECT-23K21258
[Journal Article] Genistein Directly Represses the Phosphorylation of STAT5 in Lactating Mammary Epithelial Cells2021
- Author(s)
  Tsugami Y, Wakasa H, Nishimura T, Kobayashi K.
- Journal Title
  
  ACS Omega
  
  Volume: 25 Issue: 35 Pages: 22765-22772
- DOI
  10.1021/acsomega.1c03107
- Data Source
  KAKENHI-PROJECT-23K21258
[Journal Article] Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells.2021
- Author(s)
  Tsugami Y, Wakasa H, Kawahara M, Watanabe A, Suzuki T, Nishimura T, Kobayashi K
- Journal Title
  
  Cell and Tissue Research
  
  Volume: ahead of print Issue: 2 Pages: 435-448
- DOI
  10.1007/s00441-020-03344-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02320, KAKENHI-PROJECT-18H02321, KAKENHI-PROJECT-19J10189
[Journal Article] Suppressive effects of curcumin on milk production without inflammatory responses in lactating mammary epithelial cells.2021
- Author(s)
  Kobayashi K, Tsugami Y, Suzuki N, Suzuki T, Nishimura T
- Journal Title
  
  Phytomedicine
  
  Volume: 80 Pages: 153360-153360
- DOI
  10.1016/j.phymed.2020.153360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02320
[Journal Article] Menthol from Mentha piperita suppresses the milk production of lactating mammary epithelial cells in vivo and in vitro.2020
- Author(s)
  Suzuki N, Tsugami Y, Wakasa H, Suzuki T, Nishimura T, Kobayashi K
- Journal Title
  
  Molecular Nutrition and Food Research
  
  Volume: 14 Issue: 24
- DOI
  10.1002/mnfr.202000853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02320
[Journal Article] Distinct expression patterns of fibrillar collagen types I, III, and V in association with mammary gland remodeling during pregnancy, lactation and weaning.2020
- Author(s)
  Tsutsui S, Wakasa H, Tsugami Y, Suzuki T, Nishimura T, Kobayashi K
- Journal Title
  
  Journal of Mammary Gland Biology and Neoplasia
  
  Volume: 25 Issue: 3 Pages: 219-219
- DOI
  10.1007/s10911-020-09457-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02320
[Journal Article] Adverse effects of coumestrol and genistein on mammary morphogenesis and future milk production ability of mammary epithelial cells.2020
- Author(s)
  Kumai A, Tsugami Y, Suzuki N, Suzuki T, Nishimura T, Kobayashi K
- Journal Title
  
  Advanced Biosystems
  
  Volume: in press Issue: 4 Pages: 1900187-1900187
- DOI
  10.1002/adbi.201900187
- NAID
  120007000860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02320
[Journal Article] Establishment of an in vitro culture model to study milk production and the blood-milk barrier with bovine mammary epithelial cells.2020
- Author(s)
  Tsugami Y, Suzuki N, Kawahara M, Suzuki T, Nishimura T, Kobayashi K
- Journal Title
  
  Animal Science Journal
  
  Volume: 91 Issue: 1 Pages: 1-12
- DOI
  10.1111/asj.13355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02320, KAKENHI-PROJECT-19J10189
[Journal Article] Nicotine directly affects milk production in lactating mammary epithelial cells concurrently with inactivation of STAT5 and glucocorticoid receptor in vitro.2020
- Author(s)
  Kobayashi K, Tsugami Y, Suzuki N, Suzuki T, Nishimura T
- Journal Title
  
  Toxicology in Vitro
  
  Volume: 63 Issue: 2 Pages: 104741-104741
- DOI
  10.1016/j.yexcr.2018.06.038
- NAID
  120006980036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02320
[Journal Article] Distinct expression patterns of aquaporin 3 and 5 in ductal and alveolar epithelial cells in mouse mammary glands before and after parturition.2020
- Author(s)
  Kaihoko Y, Tsugami Y, Suzuki N, Suzuki T, Nishimura T, Kobayashi K
- Journal Title
  
  Cell and Tissue Research
  
  Volume: in press Issue: 3 Pages: 513-526
- DOI
  10.1007/s00441-020-03168-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02320
[Journal Article] Distinct roles of prolactin, epidermal growth factor, and glucocorticoids in β-casein secretion pathway in lactating mammary epithelial cells.2017
- Author(s)
  Kobayashi K, Oyama S, Kuki T, Tsugami Y, Matsunaga K, Suzuki T, Nishimura T
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: 440 Pages: 16-24
- DOI
  10.1016/j.mce.2016.11.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26450441, KAKENHI-PROJECT-16K18788
[Journal Article] Pro-inflammatory cytokine TNF-α is a key inhibitory factor for lactose synthesis pathway in lactating mammary epithelial cells.2016
- Author(s)
  Kobayashi K, Kuki T, Oyama S, Kumura H
- Journal Title
  
  Experimental Cell Research
  
  Volume: 340 Issue: 2 Pages: 295-304
- DOI
  10.1016/j.yexcr.2015.10.030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26450441
[Journal Article] Prolactin and glucocorticoid signalling induces lactation-specific tight junctions concurrent with β-casein expression in mammary epithelial cells.2016
- Author(s)
  Kobayashi K, Tsugami Y, Matsunaga K, Oyama S, Kuki T, Kumura H
- Journal Title
  
  Biochimica et Biophysica Acta - Molecular and Cell Research
  
  Volume: 1863 Issue: 8 Pages: 2006-2016
- DOI
  10.1016/j.bbamcr.2016.04.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26450441
[Journal Article] Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions.2015
- Author(s)
  Kloepper JE, Baris OR, Reuter K, Kobayashi K, Weiland D, Vidali S, Paus R
- Journal Title
  
  The Journal of Investigative Dermatology
  
  Volume: 135 Issue: 3 Pages: 679-689
- DOI
  10.1038/jid.2014.475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26450441
[Journal Article] Early down-regulation of milk production after weaning by pup removal and prior to involution in mouse mammary glands.2015
- Author(s)
  Uejyo T, Oyama S, Kuki T, Kumura H, Kobayashi K
- Journal Title
  
  Cell and Tissue Research
  
  Volume: 359 Issue: 2 Pages: 643-653
- DOI
  10.1007/s00441-014-2013-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26450441
[Journal Article] Stimulatory effect of Brazilian propolis on hair growth through proliferation of keratinocytes in mice2014
- Author(s)
  Miyata S, Oda Y, Matsuo C, Kumura H, Kobayashi K
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: 62 Issue: 49 Pages: 11854-11861
- DOI
  10.1021/jf503184s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26450441
[Journal Article] Underlying mechanisms involved in the decrease of milk secretion during Escherichia coli endotoxin induced mastitis in lactating mice2013
- Author(s)
  Kobayashi K, Oyama S, Uejyo T, Kuki T, Rahman MM, Kumura H
- Journal Title
  
  Cell and Tissue Research
  
  Volume: 44 Pages: 119-119
- NAID
  120005372283
- Data Source
  KAKENHI-PROJECT-24780281
[Journal Article] Lipopolysaccharide Disrupts the Milk-Blood Barrier by Modulating Claudins in Mammary Alveolar Tight Junctions2013
- Author(s)
  Ken Kobayashi, Shoko Oyama, Atsushi Numata, Md. Morshedur Rahman, Haruto Kumura
- Journal Title
  
  PLOS ONE
  
  Volume: 8
- NAID
  120005394539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780281
[Journal Article] Lipopolysaccharide disrupts the milk-blood barrier by modulating claudins in mammary alveolar tight junctions.2013
- Author(s)
  Kobayashi K, Oyama S, Numata A, Rahman MM, Kumura H
- Journal Title
  
  PLOS ONE
  
  Volume: 23 Issue: 4 Pages: e62187-e62187
- DOI
  10.1371/journal.pone.0062187
- NAID
  120005394539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780281
[Journal Article] Underlying mechanisms involved in the decrease of milk secretion during Escherichia coli endotoxin induced mastitis in lactating mice.2013
- Author(s)
  Kobayashi K, Oyama S, Uejyo T, Kuki T, Rahman MM, Kumura H
- Journal Title
  
  Veterinary Research
  
  Volume: 44 Issue: 1 Pages: 119-119
- DOI
  10.1186/1297-9716-44-119
- NAID
  120005372283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780281
[Journal Article] Histological analysis of mammary gland remodeling caused by lipopolysaccharide in lactating mice2013
- Author(s)
  Kobayashi K, Uejyo T, Oyama S, Rahman MM, Kumura H
- Journal Title
  
  Cell and Tissue Research
  
  Volume: 354 Issue: 2 Pages: 495-506
- DOI
  10.1007/s00441-013-1688-5
- Data Source
  KAKENHI-PROJECT-24780281
[Journal Article] Progesterone maintains amniotic tight junctions during midpregnancy in mice.2011
- Author(s)
  Kobayashi K, Miwa H, Yasui M
- Journal Title
  
  Molecular and Cellular Endocrinology 337
  
  Pages: 36-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Journal Article] Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway.2011
- Author(s)
  Kobayashi K, Umezawa K, Yasui M
- Journal Title
  
  Biology of Reproduction 84
  
  Pages: 248-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Journal Article] Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway.2011
- Author(s)
  Kobayashi K.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 84 Pages: 248-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Journal Article] Progesterone maintains amniotic tight junctions during midpregnancy in mice.2011
- Author(s)
  Kobayashi K.
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: 337 Pages: 36-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Journal Article] Expression and distribution of tight junction proteins in human amnion during late pregnancy.2010
- Author(s)
  KEN KOBAYASHI
- Journal Title
  
  Placenta 31
  
  Pages: 34-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Journal Article] Bio-engineered scaffold with fibroblast for tracheal regeneration in a rabbit model.2010
- Author(s)
  Okano W, Nomoto Y, Kobayashi K, Miyake M, Suzuki T, Tada Y, Nakamura T, Watanabe M, Omori K.
- Journal Title
  
  Inflammation and Regeneration 30
  
  Pages: 34-39
- NAID
  10026094188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791631
[Journal Article] A tissue-engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose-derived stem cells.2010
- Author(s)
  Kobayashi K, Suzuki T, Nomoto Y, Tada Y, Miyake M, Hazama A, Wada I, Nakamura T, Omori K.
- Journal Title
  
  Biomaterials 31(18)
  
  Pages: 4855-4863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791631
[Journal Article] Inflammatory mediators weaken the amniotic membrane barrier throngh disruption of tight junctions.2010
- Author(s)
  Kobayashi K.
- Journal Title
  
  The Journal of Physiology
  
  Volume: 588 Pages: 4859-4869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Journal Article] Inflammatory mediators weaken the amniotic membrane barrier through disruption of tight junctions.2010
- Author(s)
  Kobayashi K, Miwa H, Yasui M
- Journal Title
  
  The Journal of Physiology 588
  
  Pages: 4859-4869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Journal Article] Expression and distribution of tight junction proteins in human amnion during late pregnancy.2010
- Author(s)
  Kobayashi K, Kadohira I, Tanaka M, Yoshimura Y, Ikeda K, Yasui, M
- Journal Title
  
  Placenta 31
  
  Pages: 158-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Journal Article] Bio-engineered scaffold with fibroblast for tracheal regeneration in a rabbit model2010
- Author(s)
  Okano W, Nomoto Y, Kobayashi K, Miyake M, Suzuki T, Tada Y, Nakamura T, Watanabe M, Omori K
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: Vol.30 Pages: 34-39
- NAID
  10026094188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791631
[Journal Article] Cellular and subcellular localization of aquaporins 1, 3, 8, and 9 in amniotic membranes during pregnancy in mice.2010
- Author(s)
  Kobayashi K, Yasui M
- Journal Title
  
  Cell and Tissue Research 342
  
  Pages: 307-316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Journal Article] A tissue-engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose-derived stem cells.2010
- Author(s)
  Kobayashi K, Suzuki T, Nomoto Y, Tada Y, Miyake M, Hazama A, Wada I, Nakamura T, Omori K
- Journal Title
  
  Biomaterials
  
  Volume: 31(18) Pages: 4855-4863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791631
[Journal Article] Dynamic changes in amniotic tight junctions during pregnancy.2009
- Author(s)
  Kobayashi K, Inai T, Shibata Y, Yasui, M
- Journal Title
  
  Placenta 30
  
  Pages: 840-847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Journal Article] Dynamic changes in amniotic tight junctions during pregnancy.2009
- Author(s)
  KEN KOBAYASHI
- Journal Title
  
  Placenta 30
  
  Pages: 840-847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790177
[Presentation] レプチンが乳腺上皮細胞の乳産生能力に及ぼす影響2023
- Author(s)
  呂　サンニ、韓　セイ、西邑　隆徳、小林謙
- Organizer
  日本畜産学会第１３１大会
- Data Source
  KAKENHI-PROJECT-23K21258
[Presentation] TRPV4チャネルの活性化が乳腺上皮細胞の乳タンパク質分泌に与える影響2023
- Author(s)
  上原　環、呂　サンニ、韓　セイ、西邑　隆徳、小林　謙
- Organizer
  第28回日本乳房炎研究会
- Data Source
  KAKENHI-PROJECT-23K21258
[Presentation] 三種類の線維性コラーゲンが乳腺上皮組織の形態形成に果たす役割を三次元培養モデルで検証する2023
- Author(s)
  二宮　和己、韓　セイ、安井　裕貴、西邑　隆徳、小林　謙
- Organizer
  第28回日本乳房炎研究会
- Data Source
  KAKENHI-PROJECT-23K21258
[Presentation] 乳腺上皮細胞における泌乳の調節機構2023
- Author(s)
  小林　謙
- Organizer
  第 126 回日本小児学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21258
[Presentation] ブロモクリプチンが乳腺上皮細胞の乳産生を低下させる機序に関する研究2022
- Author(s)
  韓セイ、呂サン霓、小山大空、西邑隆徳、小林謙
- Organizer
  第27回日本乳房炎研究会学術集会
- Data Source
  KAKENHI-PROJECT-21K19174
[Presentation] ブロモクリプチンが乳腺上皮細胞の乳産生を低下させる機序に関する研究2022
- Author(s)
  韓セイ、呂サンニ、小山大空、西邑隆徳、小林謙
- Organizer
  第２７回日本乳房炎研究会学術集会
- Data Source
  KAKENHI-PROJECT-23K21258
[Presentation] 暑熱ストレスが妊娠期の乳腺胞発達に及ぼす影響を培養モデルにより検証する2021
- Author(s)
  若狹遥、呂サンニ、小山大空、西邑隆徳、小林謙
- Organizer
  第２６回　日本乳房炎研究会学術集会
- Data Source
  KAKENHI-PROJECT-23K21258
[Presentation] 乳房炎について乳腺上皮細胞の視点から考える2021
- Author(s)
  小林　謙
- Organizer
  第 164 回日本獣医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19174
[Presentation] ヤギ乳房局所のメントール塗布が抗菌因子産生に及ぼす影響2021
- Author(s)
  大野瑠璃、新居隆浩、吉村幸則、小林謙、磯部直樹
- Organizer
  日本畜産学会第128回大会
- Data Source
  KAKENHI-PROJECT-18H02320
[Presentation] 暑熱ストレス下の高温状態が乳腺上皮細胞の細胞内シグナル経路と乳腺胞形成に及ぼす影響のin vitro検証2021
- Author(s)
  若狹遥、津上優作、草野楓也、西邑隆徳、磯部直樹、小林謙
- Organizer
  日本畜産学会第128回大会
- Data Source
  KAKENHI-PROJECT-18H02320
[Presentation] クルクミンは乳腺上皮細胞に対して影響力の大きい生理活性物質である2019
- Author(s)
  小林　謙, 津上優作, 隈井　仰, 鈴木徳宏, 鈴木貴弘, 西邑隆徳
- Organizer
  第２４回日本乳房炎研究会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02320
[Presentation] リポ多糖とリポタイコ酸がウシ乳腺上皮細胞の乳産生とタイトジャンクションに及ぼす影響2019
- Author(s)
  津上優作, 隈井　仰, 鈴木徳宏, 鈴木貴弘, 西邑隆徳, 小林　謙
- Organizer
  第２４回日本乳房炎研究会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02320
[Presentation] 温度変化が乳腺上皮細胞の乳成分産生能力に及ぼす影響2017
- Author(s)
  小林　謙、津上優作、松長康太、鈴木貴弘、西邑隆徳
- Organizer
  日本畜産学会第１２２回大会
- Place of Presentation
  神戸大学（兵庫県・神戸市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] イソフラボンが乳腺上皮細胞の乳産生へ及ぼす影響2017
- Author(s)
  津上優作、小林　謙、松長康太、鈴木貴弘、西邑隆徳
- Organizer
  日本畜産学会第１２２回大会
- Place of Presentation
  神戸大学（兵庫県・神戸市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] 炎症性サイトカインが乳腺上皮細胞の乳成分産生に及ぼす影響2017
- Author(s)
  松長康太、小林　謙、津上優作、鈴木貴弘、西邑隆徳
- Organizer
  日本畜産学会第１２２回大会
- Place of Presentation
  神戸大学（兵庫県・神戸市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] 暑熱ストレスによる体温上昇は乳腺上皮細胞の乳分泌能とバリア機能に影響を及ぼすか？2016
- Author(s)
  小林　謙、津上優作、松長康太、鈴木貴弘、西邑隆徳
- Organizer
  第21回日本乳房炎研究会
- Place of Presentation
  国立科学博物館（東京都・台東区）
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] イソフラボンの種類により乳腺上皮細胞の乳産生とタイトジャンクションに及ぼす影響が異なる2016
- Author(s)
  津上優作、小林　謙、松長康太、鈴木貴弘、西邑隆徳
- Organizer
  第21回日本乳房炎研究会
- Place of Presentation
  国立科学博物館（東京都・台東区）
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] イソフラボンが乳腺上皮細胞のβ-カゼイン産生とタイトジャンクションに及ぼす影響2015
- Author(s)
  津上優作、大山翔子、松長康太、玖村朗人、小林　謙
- Organizer
  第２０回日本乳房炎研究会学術集会
- Place of Presentation
  国立科学博物館（東京・台東区）
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] 泌乳期乳腺のタイトジャンクション形成におけるプロラクチンと糖質コルチコイドの役割2015
- Author(s)
  小林　謙、津上優作、筒井志織、松長康太、玖村朗人
- Organizer
  日本畜産学会　第１２０回大会
- Place of Presentation
  酪農学園大学（北海道・江別市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] 乳腺胞上皮細胞のin vitro培養モデルに関する検証2015
- Author(s)
  小林　謙、津上優作、松長康太、玖村朗人
- Organizer
  第２０回日本乳房炎研究会学術集会
- Place of Presentation
  国立科学博物館（東京・台東区）
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] Lipopolysaccharide投与によって誘発される泌乳期乳腺の早期反応2014
- Author(s)
  小林謙、九鬼千夏、大山翔子、玖村朗人
- Organizer
  日本乳房炎研究会第19回学術集会
- Place of Presentation
  東京
- Year and Date
  2014-10-10
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] Differential roles of prolactin and glucocorticoid in mammary alveolar tight junction formation during lactation in mice2014
- Author(s)
  Kobayashi K, Oyama S, Kuki C, Kumura H
- Organizer
  2014 ASCB/IFCB Meeting
- Place of Presentation
  Philadelphia
- Year and Date
  2014-12-07
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] 炎症性サイトカインが乳腺上皮細胞の乳糖産生経路に及ぼす影響2014
- Author(s)
  九鬼千夏、大山翔子、玖村朗人、小林謙
- Organizer
  日本乳房炎研究会第19回学術集会
- Place of Presentation
  東京
- Year and Date
  2014-10-10
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] Effect of prolactin, EGF and dexamethasone on mechanism for regulating β-casein expression and secretion2014
- Author(s)
  Oyama S, Kuki C, Kumura H, Kobayashi K
- Organizer
  2014 ASCB/IFCB Meeting
- Place of Presentation
  Philadelphia
- Year and Date
  2014-12-07
- Data Source
  KAKENHI-PROJECT-26450441
[Presentation] 乳房炎モデルマウスを用いた乳分泌停止機序に関する研究2013
- Author(s)
  小林謙
- Organizer
  日本畜産学会
- Place of Presentation
  新潟大学
- Year and Date
  2013-09-09
- Data Source
  KAKENHI-PROJECT-24780281
[Presentation] 離乳後の乳腺におけるβ-カゼインと脂肪滴の経時的な局在変化
- Author(s)
  上條敬明・九鬼千夏・大山翔子・玖村朗人・小林謙
- Organizer
  日本畜産学会
- Place of Presentation
  新潟大学（新潟市）
- Data Source
  KAKENHI-PROJECT-24780281
[Presentation] 分娩前後に増減する因子がβ‐カゼイン分泌調節機序に及ぼす影響
- Author(s)
  大山翔子・九鬼千夏・上條敬明・玖村朗人・小林謙
- Organizer
  日本畜産学会
- Place of Presentation
  新潟大学（新潟市）
- Data Source
  KAKENHI-PROJECT-24780281
[Presentation] 乳房炎モデルマウスを用いた乳分泌停止機序に関する研究
- Author(s)
  小林謙・大山翔子・九鬼千夏・上條敬明・玖村朗人
- Organizer
  日本畜産学会
- Place of Presentation
  新潟大学（新潟市）
- Data Source
  KAKENHI-PROJECT-24780281

1. 磯部直樹 (80284230)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. 川原学 (70468700)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. SUZUKI Teruhisa (80508812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. OKANO Wataru (10554420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. SUZUKI Masahiro (90513268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 津上優作 (10911563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 長澤裕哉 (20759352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 新居隆浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kobayashi Ken 小林 謙

KOBAYASHI KEN 小林 謙

KOBAYASHI Ken 小林 謙

Research Projects

Research Products

Co-Researchers

物理的刺激を起点として乳腺上皮細胞の乳分泌を調節する機構の解明Principal Investigator

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血流と搾乳を模した2系統の灌流培養システムを基盤とする培養乳生産技術の開発Principal Investigator

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Staphylococcus aureus parasitizes mammary epithelial cells to weaken the infection defense barrier.Principal Investigator

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物理化学的刺激を感知するTRPチャネルが乳腺組織の形態形成と乳分泌を制御する機構Principal Investigator

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temperature-responsive molecules in mammary epithelial cells regulate the morphogenesis and functional expression of mammary epithelial cells.Principal Investigator

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Regulatory mechanism of milk secretion by temperature-sensitive TRP channelsPrincipal Investigator

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Influence of tight junctions on milk secretion ability in lactating mammary alveolar epithelial cellsPrincipal Investigator

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Development of collection process and implant procedure of freshly isolated adipose-derived stromal vascular fraction cells (SVF) in the operation.

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The regulatory mechanism of claudins for paracellular pathway of the human amniotic epithelium.Principal Investigator

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[Journal Article] Effects of hydrostatic compression on milk production-related signaling pathways in mouse mammary epithelial cells2023

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[Journal Article] Potential effects of gingerol topical application on components of the innate immunity in lactating goat mammary glands2023

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[Journal Article] Culture Models to Investigate Mechanisms of Milk Production and Blood-Milk Barrier in Mammary Epithelial Cells: a Review and a Protocol2023

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[Journal Article] Sweet taste receptor subunit T1R3 regulates casein secretion and phosphorylation of STAT5 in mammary epithelial cells2023

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Kobayashi Ken 小林謙

KOBAYASHI KEN 小林謙

KOBAYASHI Ken 小林謙