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ISHIHARA Tomoko  石原 朋子

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石原 朋子  イシハラ トモコ

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Researcher Number 30450555
Other IDs
Affiliation (Current) 2025: 国立健康危機管理研究機構, 国立感染症研究所 研究企画調整センター, 室長
Affiliation (based on the past Project Information) *help 2023: 国立感染症研究所, 研究企画調整センター, 室長
2021: 国立感染症研究所, 研究企画調整センター, 室長
2019 – 2020: 国立感染症研究所, 細菌第一部, 主任研究官
2017 – 2018: 国立感染症研究所, 細菌第一部, 客員研究員
2014 – 2016: 国立感染症研究所, 細菌第一部, 主任研究官
2007 – 2011: National Institute of Infectious Diseases, 細菌第一部, 研究員
Review Section/Research Field
Principal Investigator
Hygiene and public health / Bacteriology (including Mycology)
Except Principal Investigator
Basic Section 58040:Forensics medicine-related
Keywords
Principal Investigator
細菌 / 微生物 / 感染症 / EHEC / 腸管出血性大腸菌 / ESBL産生菌 / 薬剤耐性 / 病原細菌 / 食中毒
Except Principal Investigator
迅速同定 … More / 高病原性微生物 / ナノポアシーケンス / 高病原性細菌 / 同属近縁種 / 亜種 / WIMP / 識別ツール / 野兎病菌 / リード / ナノポアシーケンサー Less
  • Research Projects

    (5 results)
  • Research Products

    (43 results)
  • Co-Researchers

    (4 People)
  •  Establishment of high-pathogenic microorganism identification technology with discrimination tools using nanopore sequence data

    • Principal Investigator
      武藤 淳二
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58040:Forensics medicine-related
    • Research Institution
      National Research Institute of Police Science
  •  Grasp of actual situation and analyzing the resistance mechanism of ESBL-producing enterohemorrhagic Escherichia coli in JapanPrincipal Investigator

    • Principal Investigator
      Ishihara Tomoko
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hygiene and public health
    • Research Institution
      National Institute of Infectious Diseases
  •  Analysis of new pathogenic bacteria as a cause substance of unknown food-borne infectious diseasePrincipal Investigator

    • Principal Investigator
      ISHIHARA Tomoko
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hygiene and public health
    • Research Institution
      National Institute of Infectious Diseases
  •  Analysis of an inhibition mechanism of cell destruction in infected epithelial cells by ShigellaPrincipal Investigator

    • Principal Investigator
      ISHIHARA Tomoko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      National Institute of Infectious Diseases
  •  Analysis of virulence factors on the inhibition mechanism of cell destruction by Shigella infectionPrincipal Investigator

    • Principal Investigator
      ISHIHARA Tomoko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      National Institute of Infectious Diseases

All 2024 2019 2018 2017 2016 2015 2014 2011 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] Large-scale genome analysis of bovine commensal Escherichia coli reveals that bovine-adapted E. coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains.2019

    • Author(s)
      Arimizu Y, Kirino Y, Sato MP, Uno K, Sato T, Gotoh Y, Auvray F, Brugere H, Oswald E, Mainil JG, Anklam KS, Dopfer D, Yoshino S, Ooka T, Tanizawa Y, Nakamura Y, Iguchi A, Morita-Ishihara T, Ohnishi M, Akashi K, Hayashi T, Ogura Y
    • Journal Title

      Genome Research

      Volume: 29 Issue: 9 Pages: 1495-1505

    • DOI

      10.1101/gr.249268.119

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09183, KAKENHI-PROJECT-17H04077, KAKENHI-PROJECT-16H06279
  • [Journal Article] Epidemiology and genotypic characterisation of dissemination patterns of uropathogenic Escherichia coli in a community2019

    • Author(s)
      Matsukawa M.、Igarashi M.、Watanabe H.、Qin L.、Ohnishi M.、Terajima J.、Iyoda S.、Morita-Ishihara T.、Tateda K.、Ishii Y.、Saga T.、Aoki K.、Bonomo R. A.
    • Journal Title

      Epidemiology and Infection

      Volume: 147

    • DOI

      10.1017/s0950268819000426

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09183
  • [Journal Article] A Geographically Widespread Outbreak Investigation and Development of a Rapid Screening Method Using Whole Genome Sequences of Enterohemorrhagic Escherichia coli O1212017

    • Author(s)
      Lee Ken-ichi、Morita-Ishihara Tomoko、Iyoda Sunao、Ogura Yoshitoshi、Hayashi Tetsuya、Sekizuka Tsuyoshi、Kuroda Makoto、Ohnishi Makoto、EHEC Working Group in Japan
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 701-701

    • DOI

      10.3389/fmicb.2017.00701

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08486, KAKENHI-PROJECT-17K09183, KAKENHI-PROJECT-26870873
  • [Journal Article] Molecular epidemiological analyses using whole genome sequencing of enterohemorrhagic Escherichia coli2017

    • Author(s)
      Lee KI, Morita-Ishihara T, Izumiya H, Iyoda S, Ohnishi M
    • Journal Title

      化学療法の領域

      Volume: 33 Pages: 137-141

    • Data Source
      KAKENHI-PROJECT-17K09183
  • [Journal Article] Molecular epidemiological analyses using whole genome sequencing of enterohemorrhagic Escherichia coli2017

    • Author(s)
      Lee KI, Morita-Ishihara T, Izumiya H, Iyoda S, Ohnishi M
    • Journal Title

      化学療法の領域

      Volume: 33 Pages: 137-141

    • Data Source
      KAKENHI-PROJECT-26870873
  • [Journal Article] Characterization of Shiga toxin-producing <i>Escherichia coli</i> from feces of sika deer (<i>Cervus nippon</i>) in Japan using PCR binary typing analysis to evaluate their potential human pathogenicity2017

    • Author(s)
      Kabeya H, Sato S, Oda S, Kawamura M, Nagasaka M, Kuranaga M, Yokoyama E, Hirai S, Iguchi A, Ishihara T, Kuroki T, Morita-Ishihara T, Iyoda S, Terajima J, Ohnishi M, Maruyama S.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 79 Issue: 5 Pages: 834-841

    • DOI

      10.1292/jvms.16-0568

    • NAID

      130005635466

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26450412, KAKENHI-PROJECT-17K09183, KAKENHI-PROJECT-26870873
  • [Journal Article] Secondary Shiga Toxin-Producing Escherichia coli Infection, Japan, 2010-2012.2016

    • Author(s)
      Morita-Ishihara T, Iyoda S, Iguchi A, Ohnishi M.
    • Journal Title

      Emerg Infect Dis.

      Volume: 22(12) Issue: 12 Pages: 2181-2184

    • DOI

      10.3201/eid2212.160783

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08486, KAKENHI-PROJECT-26870873
  • [Journal Article] Molecular Subtyping in Cholera Outbreak, Lao People's Democratic Republic, 20102011

    • Author(s)
      Sithivong N, Morita-Ishihara T, Vongdouangchanh A, Phouthavane T, Chomlasak K, Sisavath L, Khamphaphongphane B, Sengkeopraseuth B, Vongprachanh P, Keosavanh O, Southalack K, Jiyoung L, Tsuyuoka R, Ohinishi M, Izumiya H
    • Journal Title

      Emerging Infectious Diseases

      Volume: 17 Issue: 11 Pages: 2060-2062

    • DOI

      10.3201/eid1711.110280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Journal Article] Interaction between Enterohemorrhagic Escherichia coli O157 : H7 EspFu and IRSp53 induces dynamic membrane remodeling in epithelial cells2009

    • Author(s)
      Morita-Ishihara T, Terajima J, Watanabe H, Izumiya H
    • Journal Title

      Japanese Journal of Infectious Diseases VOL.62

      Pages: 351-355

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Journal Article] Osmotic-Response Regulation of invE Gene Expression in Shigella sonnei2009

    • Author(s)
      Mitobe J, Morita-Ishihara T, Ishihama A, Watanabe H
    • Journal Title

      BMC Microbiology

      Volume: 9 Issue: 1 Pages: 110-122

    • DOI

      10.1186/1471-2180-9-110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Journal Article] Osmotic-Response Regulation of invE Gene Expression in Shigella sonnei2009

    • Author(s)
      Mitobe J, Morita-Ishihara T, Ishihama A, Watanabe H
    • Journal Title

      BMC Microbiology VOL.9

      Pages: 110-122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Journal Article] Interaction between Enterohemorrhagic Escherichia coli O157 : H7 EspFu and IRSp53 induces dynamic membrane remodeling in epithelial cells2009

    • Author(s)
      Morita-Ishihara T, Terajima J, Watanabe H, Izumiya H
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 62 Pages: 351-355

    • URL

      http://www0.nih.go.jp/JJID/62/351.pdf

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Journal Article] Characterization of Shigella sonnei isolates from travel-associated cases in Japan2009

    • Author(s)
      Izumiya H, Tada Y, Itoh K, Nishimura K, Morita-Ishihara T, Ohnishi M, Terajima J, Watanabe H
    • Journal Title

      Journal of Medical Microbiology

      Volume: 58 Issue: 11 Pages: 1486-1491

    • DOI

      10.1099/jmm.0.011809-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Journal Article] Antimicrobial Resistance and Genetic Characteristics of Salmonella Typhim urium Isolated from Horses in Hokkaido, Japan2009

    • Author(s)
      Niwa H, Anzai T, Izumiya H, Morita-Ishihara T, Uchida I, Tozaki T, Hobo S
    • Journal Title

      Journal of Veterinary Medical Science VOL.71

      Pages: 1115-1119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Journal Article] Characterization of Shigella sonnei isolates from travel-associated casesin Japan2009

    • Author(s)
      Izumiya H, Tada Y, Itoh K, Nishimura K, Morita-Ishihara T, Ohnishi M, Terajima J, Watanabe H
    • Journal Title

      Journal of Medical Microbiology VOL.58

      Pages: 1486-1491

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Journal Article] Antimicrobial Resistance and Genetic Characteristics of Salmonella Typhimurium Isolated from Horses in Hokkaido, Japan2009

    • Author(s)
      Niwa H, Anzai T, Izumiya H, Morita-Ishihara T, Uchida I, Tozaki T, Hobo S
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 71 Issue: 8 Pages: 1115-1119

    • DOI

      10.1292/jvms.71.1115

    • NAID

      130000134465

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Journal Article] Mechanism of cell adhesion and invasion by Type III secretion machinery in Enteropathogenic bacteria2008

    • Author(s)
      Morita-Ishihara T
    • Journal Title

      Japanese Journal of Lactic acid Bacteria 19

      Pages: 37-45

    • Data Source
      KAKENHI-PROJECT-19890277
  • [Journal Article] Involvement of RNA binding protein hfq in the post-transcriptional regulation of invE gene expression in Shigella sonnei.2008

    • Author(s)
      Mitobe J, Morita-Ishihara T, Ishihama A, Watanabe H.
    • Journal Title

      The Journal of Biological Chemistry. 283

      Pages: 5738-5747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19890277
  • [Journal Article] Mechanism of cell adhesion and invasion by Type III secretion machinery in Enteropathogenic bacteria.2008

    • Author(s)
      Morita-Ishihara T.
    • Journal Title

      Japanese Journal of Lactic acid Bacteria. 19

      Pages: 37-45

    • Data Source
      KAKENHI-PROJECT-19890277
  • [Journal Article] Molecular characterization of Enterohemorrhagic Escherichia coli O157 : H7 isolates dispersed across Japan by pulsed-field gel electrophoresis and multiple-locus variable number tandem repeat analysis.2008

    • Author(s)
      Pei Y, Terajima J, Saito Y, Suzuki R, Takai N, Izumiya H, Morita-Ishihara T, Ohnishi M, Miura M, Iyoda S, Mitobe J, Wang B, Watanabe H.
    • Journal Title

      Japanese Journal of Infectious Diseases. 61

      Pages: 58-64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19890277
  • [Presentation] 国立感染症研究所感染症危機管理研究センターのセキュリティ部門との連携・協力について2024

    • Author(s)
      北山明子、濵田優一、太田雅之、村上耕介、高橋健一郎、石原朋子、齋藤智也
    • Organizer
      第29回日本災害医学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-23K09781
  • [Presentation] The increased incidence and epidemic strain of Shiga toxin-producing Escherichia coli O146 infection in Japan2018

    • Author(s)
      Tomoko Morita-Ishihara, Sunao Iyoda, Jun Terajima, Hidemasa Izumiya, Makoto Ohnishi, EHEC Working group
    • Organizer
      10th International Symposium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli Infections agnosticians
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09183
  • [Presentation] 2015年のNon-O157/O26/O111 腸管出血性大腸菌における分子疫学解析2016

    • Author(s)
      石原朋子,伊豫田淳,泉谷秀昌,大西真
    • Organizer
      第37回日本食品微生物学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-15
    • Data Source
      KAKENHI-PROJECT-26870873
  • [Presentation] Trend of enterohemorrhagic E.coli O146 in Japan2016

    • Author(s)
      石原朋子、伊豫田淳、寺嶋淳、泉谷秀昌、大西真、EHEC Working group
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2016-03-23
    • Data Source
      KAKENHI-PROJECT-26870873
  • [Presentation] 2015-2016年におけるEHEC広域PFGE型の発生動向2016

    • Author(s)
      石原朋子、伊豫田淳、泉谷秀昌、李謙一、大西真
    • Organizer
      第20回腸管出血性大腸菌感染症研究会
    • Place of Presentation
      富山
    • Year and Date
      2016-11-10
    • Data Source
      KAKENHI-PROJECT-26870873
  • [Presentation] Potential risk of Shiga-toxin producing E. coli (STEC) infection: investigation of STEC isolates from asymptomatic carrier in Japan2015

    • Author(s)
      Tomoko Morita-Ishihara、Sunao Iyoda、Atsushi Iguchi、Makoto Ohnishi
    • Organizer
      VTEC 2015 The 9th Triennial International Symposium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli Infections
    • Place of Presentation
      米国、Boston
    • Year and Date
      2015-09-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26870873
  • [Presentation] O157、O26、O111以外の腸管出血性大菌2014 年分離株におけるPFGE解析2015

    • Author(s)
      石原朋子、伊豫田淳、泉谷秀昌、大西真、EHECワーキング グループ
    • Organizer
      第19回腸管出血性大菌感染症研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-09
    • Data Source
      KAKENHI-PROJECT-26870873
  • [Presentation] 健常者糞便由来の腸管出血性大腸菌についての解析2014

    • Author(s)
      石原朋子、伊豫田淳、井口純、大西真
    • Organizer
      第18回腸管出血性大腸菌感染症研究会
    • Place of Presentation
      京都
    • Year and Date
      2014-07-15
    • Data Source
      KAKENHI-PROJECT-26870873
  • [Presentation] Enterohaemorrhagic Escherichia coli O157 delivers a type 3 effector EspO1-2 into host cells to suppress RhoA activity enhanced by another type 3 effector EspM2 which acts as a RhoA GEF2011

    • Author(s)
      石原朋子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Presentation] An EHEC type 3 effector EspO1-2 controls EspM2-mediated RhoA signaling pathway by protein-protein interaction to prevent detachment of EHEC-infected host cells2011

    • Author(s)
      石原朋子
    • Organizer
      The International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-07
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Presentation] Enterohaemorrhagic Escherichia coli O157 delivers a type 3 effector EspO1-2 into host cells to suppress RhoA activity enhanced by another type 3 effector EspM2 which acts as a RhoA GEF2011

    • Author(s)
      石原朋子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Presentation] An EHEC type 3 effector EspO1-2 controls EspM2-mediated RhoA signaling pathway by protein-protein interaction to prevent detachment of EHEC-infected host cells2011

    • Author(s)
      石原朋子
    • Organizer
      The International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-07
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Presentation] タイプ3エフェクターEspO1-2は、腸管出血性大腸菌の感染細胞内においてEspM2を介したRhoA活性を制御する2011

    • Author(s)
      石原朋子
    • Organizer
      第94回日本細菌学会関東支部総会
    • Place of Presentation
      北里大学(東京都)
    • Year and Date
      2011-10-06
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Presentation] タイプ3エフェクターEspO1-2は、腸管出血性大腸菌の感染細胞内においてEspM2を介したRhoA活性を制御する2011

    • Author(s)
      石原朋子
    • Organizer
      第94回日本細菌学会関東支部総会
    • Place of Presentation
      東京都
    • Year and Date
      2011-10-06
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Presentation] Membrane remodeling in epithelial cells induced by interaction between EHEC EspFu and IRSp532010

    • Author(s)
      石原朋子
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-27
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Presentation] Membrane remodeling in epithelial cells induced by interaction between EHEC EspFu and IRSp532010

    • Author(s)
      石原朋子、泉谷秀昌、寺嶋淳、渡辺治雄
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Presentation] Interaction between Enterohemorrhagic Escherichia coli O157 : H7 EspFu and IRSp53 induces dynamic membrane remodeling in epithelial cells2009

    • Author(s)
      石原朋子
    • Organizer
      第92回日本細菌学会関東支部総会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Presentation] 赤痢菌による感染上皮細胞の破壊抑制機構についての解析2009

    • Author(s)
      石原朋子
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-12
    • Data Source
      KAKENHI-PROJECT-19890277
  • [Presentation] Interaction between Enterohemorrhagic Escherichia coli O157:H7 EspFu and IRSp53 induces dynamic membrane remodeling in epithelial cells2009

    • Author(s)
      石原朋子、寺嶋淳、渡邉治雄、泉谷秀昌
    • Organizer
      第92回日本細菌学会関東支部総会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2009-11-05
    • Data Source
      KAKENHI-PROJECT-21790433
  • [Presentation] Analysis on the inhibition mechanism of cell destruction by Shigella Infection2008

    • Author(s)
      石原朋子
    • Organizer
      Forum of the Network of Research Centers on Infectious Diseases
    • Place of Presentation
      ベトナム
    • Year and Date
      2008-10-06
    • Data Source
      KAKENHI-PROJECT-19890277
  • [Presentation] 赤痢菌感染による細胞破壊抑制機構の解析2008

    • Author(s)
      石原朋子
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-26
    • Data Source
      KAKENHI-PROJECT-19890277
  • [Presentation] Analysis on the inhibition mechanism of cell destruction by Shigella infection2008

    • Author(s)
      石原朋
    • Organizer
      Forum of the Network of Research Centers on Infectious Diseases
    • Place of Presentation
      ベトナム
    • Year and Date
      2008-10-06
    • Data Source
      KAKENHI-PROJECT-19890277
  • [Presentation] 日本における健常者由来腸管出血性大腸菌の解析

    • Author(s)
      石原朋子、伊豫田淳、井口純、大西真
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26870873
  • 1.  武藤 淳二 (80432186)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  堀田 明豊 (90392323)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  SETO Kazuko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  伊豫田 淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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