Sasaki Daisuke 佐々木大輔

… Alternative Names

佐々木大輔ササキダイスケ

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Researcher Number	30453327
Other IDs
Affiliation (Current)	2025: 岩手医科大学, 歯学部, 教授
Affiliation (based on the past Project Information) *help	2025: 岩手医科大学, 歯学部, 特任教授 2023: 岩手医科大学, 歯学部, 特任教授 2019 – 2022: 岩手医科大学, 歯学部, 准教授 2018: 岩手医科大学, 歯学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 57080:Social dentistry-related Except Principal Investigator Basic Section 57020:Oral pathobiological science-related / Basic Section 57010:Oral biological science-related
Keywords	Except Principal Investigator 歯周病 / ジペプチジルペプチダーゼ / 歯周病原細菌 / タンパク代謝 / ジペプチド / 糖尿病 / 苦味受容体 / 血管内皮細胞 / 歯周病原菌 / 血管新生因子 … More / 低体重出生 / 口腔細菌 / トランスポーター / DPP / ジペプチジルぺプチダーゼ / P. gingivalis Less

国民皆歯科健診に向けた非侵襲的アプローチによる潜在糖尿病患者の発掘Principal Investigator
- Principal Investigator
  
  佐々木大輔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Iwate Medical University
Function of dipeptidyl-peptidases of periodontal bacteria in proliferation and pathogenicity
- Principal Investigator
  
  根本孝幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Iwate Medical University
Effects of periodontal pathogenic bacteria mediated by bitter taste receptors related to low birth weight
- Principal Investigator
  
  Ishikawa Taichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Iwate Medical University
The growth mechanism of Porphyromonas gingivalis, a member of periodontpathic bacteria, via incorporation of dipeptides.
- Principal Investigator
  
  Shimoyama Yu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Iwate Medical University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Immunoelectron Microscopic Analysis of Dipeptidyl-Peptidases and Dipeptide Transporter Involved in Nutrient Acquisition in Porphyromonas gingivalis2023
- Author(s)
  Shimoyama Yu、Sasaki Daisuke、Ohara-Nemoto Yuko、Nemoto Takayuki K.、Nakasato Manami、Sasaki Minoru、Ishikawa Taichi
- Journal Title
  
  Current Microbiology
  
  Volume: 80 Issue: 4 Pages: 106-106
- DOI
  10.1007/s00284-023-03212-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17045, KAKENHI-PROJECT-19K10045, KAKENHI-PROJECT-19K10071, KAKENHI-PROJECT-23K09125
[Journal Article] Extracellular Tryptophanyl-tRNA Synthetase from Alveolar Epithelial Cells Infected with Staphylococcus aureu s and its Inflammatory Response2023
- Author(s)
  Sato Shu、Sasaki Minoru、Shimoyama Yu、Sato Kenichi、Ishikawa Taichi
- Journal Title
  
  Dental Journal of Iwate Medical University
  
  Volume: 48 Issue: 1 Pages: 1-10
- DOI
  10.20663/iwateshigakukaishi.48.1_1
- ISSN
  0385-1311, 2424-1822
- Year and Date
  2023-06-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09925
[Journal Article] F-type proton-pumping ATPase mediates acid tolerance in Streptococcus mutans2023
- Author(s)
 Sekiya Mizuki、Ikeda Kazuya、Yonai Ayaka、Ishikawa Taichi、Shimoyama Yu、Kodama Yoshitoyo、Sasaki Minoru、Nakanishi-Matsui Mayumi
- Journal Title
 
 Journal of Applied Microbiology
 
 Volume: 134 Issue: 4
- DOI
 10.1093/jambio/lxad073
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21K06546, KAKENHI-PROJECT-20K09925, KAKENHI-PROJECT-23K21360
[Journal Article] Oral and Gut Microbial Dysbiosis and Non-alcoholic Fatty Liver Disease: The Central Role of Porphyromonas gingivalis.2022
- Author(s)
  Wang T, Ishikawa T, Sasaki M, Chiba
- Journal Title
  
  Front Med (Lausanne)
  
  Volume: No Pages: 822190-822190
- DOI
  10.3389/fmed.2022.822190
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07737, KAKENHI-PROJECT-20K09925
[Journal Article] A genomic sequence of the type II-A clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system in Mycoplasma salivarium strain ATCC 298032022
- Author(s)
  Harumi Mizuki, Yu Shimoyama, Taichi Ishikawa, Minoru Sasaki
- Journal Title
  
  Journal of Oral Microbiology
  
  Volume: 14 Issue: 1 Pages: 2008153-2008153
- DOI
  10.1080/20002297.2021.2008153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09925
[Journal Article] Abiotrophia defectiva DnaK Promotes Fibronectin-Mediated Adherence to HUVECs and Induces a Proinflammatory Response2021
- Author(s)
  Sasaki Minoru、Shimoyama Yu、Kodama Yoshitoyo、Ishikawa Taichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 16 Pages: 8528-8528
- DOI
  10.3390/ijms22168528
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09925
[Journal Article] Uptake of Nanotitania by Gingival Epithelial Cells Promotes Inflammatory Response and Is Accelerated by Porphyromonas gingivalis Lipopolysaccharide: An In Vitro Study2021
- Author(s)
  Sugawara Shiho、Ishikawa Taichi、Sato Shu、Kihara Hidemichi、Taira Masayuki、Sasaki Minoru、Kondo Hisatomo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 15 Pages: 8084-8084
- DOI
  10.3390/ijms22158084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09925, KAKENHI-PROJECT-20K18642
[Journal Article] The Role of Lactic Acid on Wound Healing, Cell Growth, Cell Cycle Kinetics, and Gene Expression of Cultured Junctional Epithelium Cells in the Pathophysiology of Periodontal Disease2021
- Author(s)
  Taichi Ishikawa、Daisuke Sasaki、Ryo Aizawa、Matsuo Yamamoto、Takashi Yaegashi、Tarou Irie、Minoru Sasaki
- Journal Title
  
  Pathogens
  
  Volume: 10 Issue: 11 Pages: 1507-1507
- DOI
  10.3390/pathogens10111507
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10073, KAKENHI-PROJECT-20K09925, KAKENHI-PROJECT-20K09978
[Journal Article] Titanium nanoparticles potentially affect gingival tissue through IL-13α2 receptor expression2021
- Author(s)
  Ishikawa Taichi、Sugawara Shiho、Kihara Hidemichi、Hanasaka Tomohito、Hatakeyama Wataru、Sasaki Minoru、Kondo Hisatomo
- Journal Title
  
  Journal of Oral Science
  
  Volume: 63 Issue: 3 Pages: 263-266
- DOI
  10.2334/josnusd.21-0130
- NAID
  130008058457
- ISSN
  1343-4934, 1880-4926
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09925, KAKENHI-PROJECT-20K18642
[Journal Article] Effect of Butyric Acid in the Proliferation and Migration of Junctional Epithelium in the Progression of Periodontitis: An In Vitro Study2021
- Author(s)
  Taichi Ishikawa、Daisuke Sasaki、Ryo Aizawa、Yu Shimoyama、Matsuo Yamamoto、Tarou Irie、 Minoru Sasaki
- Journal Title
  
  Dentistry Journal
  
  Volume: 9 Issue: 4 Pages: 44-44
- DOI
  10.3390/dj9040044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10073, KAKENHI-PROJECT-20K09925, KAKENHI-PROJECT-20K09978
[Journal Article] Tryptophanyl tRNA Synthetase from Human Macrophages Infected by Porphyromonas gingivalis Induces a Proinflammatory Response Associated with Atherosclerosis2021
- Author(s)
  Sasaki Minoru、Shimoyama Yu、Kodama Yoshitoyo、Ishikawa Taichi
- Journal Title
  
  Pathogens
  
  Volume: 10 Issue: 12 Pages: 1648-1648
- DOI
  10.3390/pathogens10121648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09925
[Journal Article] Tyrosine tRNA synthetase as a novel extracellular immunomodulatory protein in Streptococcus anginosus2020
- Author(s)
  Shimoyama Yu、Ishikawa Taichi、Kodama Yoshitoyo、Kimura Shigenobu、Sasaki Minoru
- Journal Title
  
  FEMS Microbiology Letters
  
  Volume: 367 Issue: 18
- DOI
  10.1093/femsle/fnaa153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K12036, KAKENHI-PROJECT-18K09557
[Journal Article] Contribution of different adherent properties of Granulicatella adiacens and Abiotrophia defectiva to their associations with oral colonization and the risk of infective endocarditis2020
- Author(s)
 Sasaki Minoru、Shimoyama Yu、Ishikawa Taichi、Kodama Yoshitoyo、Tajika Shihoko、Kimura Shigenobu
- Journal Title
 
 Journal of Oral Science
 
 Volume: 62 Issue: 1 Pages: 36-39
- DOI
 10.2334/josnusd.19-0021
- NAID
 130007791543
- ISSN
 1343-4934, 1880-4926
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-18K09557, KAKENHI-PROJECT-17K11623, KAKENHI-PROJECT-17K12036
[Journal Article] Effects of denture adhesives on growth and morphological transformation of Candida albicans2019
- Author(s)
 Nomura Taro、Murakami Tomohiko、Shimoyama Yu、Kobayashi Takuya、Furuya Junichi、Sasaki Minoru、Kondo Hisatomo
- Journal Title
 
 J Prosthodont Res
 
 Volume: 64 Issue: 1 Pages: 78-84
- DOI
 10.1016/j.jpor.2019.04.006
- NAID
 130007845613
- ISSN
 1883-1958, 1883-9207
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-18K09557
[Journal Article] Proton-pumping F-ATPase plays an important role in Streptococcus mutans under acidic conditions2019
- Author(s)
  Sekiya Mizuki、Izumisawa Shintaro、Iwamoto-Kihara Atsuko、Fan Yang、Shimoyama Yu、Sasaki Minoru、Nakanishi-Matsui Mayumi
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 666 Pages: 46-51
- DOI
  10.1016/j.abb.2019.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06629, KAKENHI-PROJECT-18K06661, KAKENHI-PROJECT-18K09557, KAKENHI-PROJECT-16K07357
[Journal Article] Distribution of dipeptidyl peptidase (DPP) 4, DPP5, DPP7, and DPP11 in human oral microbiota ? potent biomarkers indicating presence of periodontopathic bacteria2018
- Author(s)
  Ohara-Nemoto Yuko、Shimoyama Yu、Nakasato Manami、Nishimata Haruka、Ishikawa Taichi、Sasaki Minoru、Kimura Shigenobu、Nemoto Takayuki K
- Journal Title
  
  FEMS Microbiology Letters
  
  Volume: 365 Pages: 1-7
- DOI
  10.1093/femsle/fny221
- NAID
  120006987966
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K12036, KAKENHI-PROJECT-18K09557, KAKENHI-PROJECT-17K17286, KAKENHI-PROJECT-17K17336, KAKENHI-PROJECT-16K11481
[Journal Article] Porphyromonas gingivalis is highly sensitive to inhibitors of a proton-pumping ATPase.2018
- Author(s)
  Mizuki Sekiya, Yu Shimoyama, Taichi Ishikawa, Minoru Sasaki, Masamitsu Futai, Mayumi Nakanishi-Matsui.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 498 Issue: 4 Pages: 837-841
- DOI
  10.1016/j.bbrc.2018.03.066
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17286, KAKENHI-PROJECT-15K07939, KAKENHI-PROJECT-16K18877, KAKENHI-PROJECT-17K11623, KAKENHI-PROJECT-18K09557
[Journal Article] The fibronectin-binding protein homologue Fbp62 of Streptococcus anginosus is a potent virulence factor2018
- Author(s)
  Kodama Y, Ishikawa T, Shimoyama Y, Sasaki D, Kimura S, Sasaki M.
- Journal Title
  
  Microbiol. Immunol.
  
  Volume: 62 Issue: 10 Pages: 624-634
- DOI
  10.1111/1348-0421.12646
- NAID
  40021702616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11623, KAKENHI-PROJECT-18K09557, KAKENHI-PROJECT-17K17286
[Journal Article] Aciduricity and acid tolerance mechanisms of Streptococcus anginosus2018
- Author(s)
 Sasaki M, Kodama Y, Shimoyama Y, Ishikawa T, Kimura S.
- Journal Title
 
 J. Gen. Appl. Microbiol.
 
 Volume: 64 Issue: 4 Pages: 174-179
- DOI
 10.2323/jgam.2017.11.005
- NAID
 130007494295
- ISSN
 0022-1260, 1349-8037
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-17K11623, KAKENHI-PROJECT-18K09557
[Presentation] Localization of DPPs and dipeptide transporter Pot in Porphyromonas gingivalis defined by IEM2021
- Author(s)
  Yu Shimoyama, Yuko Ohara-Nemoto, Takayuki K. Nemoto, Taichi Ishikawa, Daisuke Sasaki, Yoshitoyo Kodama, Shigenobu Kimura and Minoru Sasaki
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K09557
[Presentation] The effect of bacterial lipopolysaccharide on the expression of angiogenic factors in HUVEC2020
- Author(s)
  Taichi Ishikawa, Yu Shimoyama, Yoshitoyo Kodama, Masahito Ogasawara, Minoru Sasaki
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-20K09925
[Presentation] A periodontopathic bacterial metabolite effects on exacerbation of ameloblastoma2019
- Author(s)
  Taichi Ishikawa, Yu Shimoyama, Yoshitoyo Kodama and Minoru Sasaki
- Organizer
  第61回歯科基礎医学会総会
- Data Source
  KAKENHI-PROJECT-18K09557
[Presentation] Expressions Of TAS2Rs On HUVEC By The Periodontopathic Bacterial Infectio2019
- Author(s)
  Taichi Ishikawa, Yu Shimoyama, Yoshitoyo Kodama, Masahito Ogasawara and Minoru Sasaki
- Organizer
  97th International assosiation of dental research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09557
[Presentation] Comparison of CRISPR sequences among five Mycoplasma salivarium strains2019
- Author(s)
  Yu Shimoyama, Taichi Ishikawa, Yoshitoyo Kodama, Shigenobu Kimura and Minoru Sasaki
- Organizer
  第61回歯科基礎医学会総会
- Data Source
  KAKENHI-PROJECT-18K09557
[Presentation] The effect of bacterial infection on the expression of TAS2R in human umbilical vein endothelial cells.2019
- Author(s)
  Taichi Ishikawa, Yu Shimoyama, Yoshitoyo Kodama, Masahito Ogasawara and Minoru Sasaki
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K09557
[Presentation] Signal transduction pathway of an extracellular antigen from Streptococcus anginosus for inflammatory responses2019
- Author(s)
  Yu Shimoyama, Taichi Ishikawa, Yoshitoyo Kodama, Shigenobu Kimura and Minoru Sasaki
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K09557
[Presentation] Streptococcus anginosus 新規病原因子としてのaminoacyl-tRNA synthetase2018
- Author(s)
  下山　佑，石河　太知，古玉　芳豊，佐々木　実
- Organizer
  第72回日本細菌学会東北支部総会
- Data Source
  KAKENHI-PROJECT-18K09557
[Presentation] Streptococcus anginosus 菌体外タンパク質抗原の炎症応答誘導2018
- Author(s)
  下山　佑，石河　太知，古玉　芳豊，木村　重信，佐々木　実
- Organizer
  第60歯科基礎医学会総会
- Data Source
  KAKENHI-PROJECT-18K09557

1. Ishikawa Taichi (10569247)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. Shimoyama Yu (90453331)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. 根本優子 (10164667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 佐々木実 (40187133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
5. 木村重信 (10177917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 小笠原正人 (00325367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 馬場長 (60508240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小山理恵 (20291619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 三浦利貴 (00976582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 根本孝幸 (90164665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 鈴木茉那美 (10823841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. WANG Tei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. SEKIYA Mizuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 中里茉那美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 入江太朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Sasaki Daisuke 佐々木 大輔

佐々木 大輔 ササキ ダイスケ

Research Projects

Research Products

Co-Researchers

国民皆歯科健診に向けた非侵襲的アプローチによる潜在糖尿病患者の発掘Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Function of dipeptidyl-peptidases of periodontal bacteria in proliferation and pathogenicity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of periodontal pathogenic bacteria mediated by bitter taste receptors related to low birth weight

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The growth mechanism of Porphyromonas gingivalis, a member of periodontpathic bacteria, via incorporation of dipeptides.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Immunoelectron Microscopic Analysis of Dipeptidyl-Peptidases and Dipeptide Transporter Involved in Nutrient Acquisition in Porphyromonas gingivalis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular Tryptophanyl-tRNA Synthetase from Alveolar Epithelial Cells Infected with Staphylococcus aureu s and its Inflammatory Response2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] F-type proton-pumping ATPase mediates acid tolerance in <i>Streptococcus mutans</i>2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oral and Gut Microbial Dysbiosis and Non-alcoholic Fatty Liver Disease: The Central Role of Porphyromonas gingivalis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A genomic sequence of the type II-A clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system in Mycoplasma salivarium strain ATCC 298032022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abiotrophia defectiva DnaK Promotes Fibronectin-Mediated Adherence to HUVECs and Induces a Proinflammatory Response2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uptake of Nanotitania by Gingival Epithelial Cells Promotes Inflammatory Response and Is Accelerated by Porphyromonas gingivalis Lipopolysaccharide: An In Vitro Study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Role of Lactic Acid on Wound Healing, Cell Growth, Cell Cycle Kinetics, and Gene Expression of Cultured Junctional Epithelium Cells in the Pathophysiology of Periodontal Disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Titanium nanoparticles potentially affect gingival tissue through IL-13α2 receptor expression2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

Sasaki Daisuke 佐々木大輔

佐々木大輔ササキダイスケ