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OGAWA TAKUYA  小川 拓哉

… Alternative Names

小川 拓哉  オガワ タクヤ

OGAWA Takuya  小川 拓哉

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Researcher Number 30457147
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-9194-3079
Affiliation (Current) 2025: 国際医療福祉大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 国際医療福祉大学, 薬学部, 准教授
2012 – 2015: 国際医療福祉大学, 薬学部, 講師
2011: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 研究員
2008 – 2010: Nara Institute of Science and Technology, バイオサイエンス研究科, 助教
Review Section/Research Field
Principal Investigator
Orthopaedic surgery / Basic Section 47060:Clinical pharmacy-related / Integrated Nutrition Science
Except Principal Investigator
Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords
Principal Investigator
L-セリン / 破骨細胞 / セリン / 分化 / 骨・軟骨代謝学 / シグナル伝達 / 発現制御 / 発生・分化 / 細胞・組織 / アミノ酸 … More / 近接依存性標識法 / CRISPRスクリーニング / DC-STAMP / 細胞融合 / マクロファージ / 腫瘍 / Phgdh / アミノ酸飢餓ストレス / RANK … More
Except Principal Investigator
琉球弧 / CRE / smad / 骨格筋細胞 / 骨芽細胞 / 骨形成 / ロコモティブシンドローム / 骨粗しょう症 Less
  • Research Projects

    (5 results)
  • Research Products

    (44 results)
  • Co-Researchers

    (6 People)
  •  Exploration of the regulatory mechanism of cell-cell fusion in osteoclastogenesis by CRISPR screening and proximity labelingPrincipal Investigator

    • Principal Investigator
      小川 拓哉
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      International University of Health and Welfare
  •  ロコモ改善を志向した骨代謝を制御する天然機能分子の探索

    • Principal Investigator
      矢作 忠弘
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      Nihon University
  •  Significance of L-serine in intercellular communication between cancer cells and tumor-associated macrophagesPrincipal Investigator

    • Principal Investigator
      Ogawa Takuya
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Integrated Nutrition Science
    • Research Institution
      International University of Health and Welfare
  •  L-serine starvation response in osteoclast precursors and its physiological significance in the bone marrow microenvironmentPrincipal Investigator

    • Principal Investigator
      OGAWA Takuya
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Nara Institute of Science and Technology
  •  L-serine regulation of RANK signaling machinery and its role in bone metabolismPrincipal Investigator

    • Principal Investigator
      OGAWA Takuya
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Nara Institute of Science and Technology

All 2022 2016 2015 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] Effects of a Whole Plant Extract of Scutellaria rubropunctata var. rubropunctata on Bone Metabolism with Estrogen Receptor Activation.2022

    • Author(s)
      Watanabe M, Yahagi T, Shirayama T, Miyake K, Kotani H, Ogawa T, Matsuzaki K
    • Journal Title

      Plants

      Volume: 11 (16) Issue: 16 Pages: 2075-2075

    • DOI

      10.3390/plants11162075

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06670
  • [Journal Article] Adaptive response to L-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts2016

    • Author(s)
      Tomoko Sayano, Yuki Kawano, Wataru Kusada, Yashiho Arimoto, Kayoko Esaki, Momoko Hamano, Miyako Udono, Yoshinori Katakura, Takuya Ogawa, Hisanori Kato, Yoshio Hirabayashi, Shigeki Furuya
    • Journal Title

      FEBS Open Bio

      Volume: 6 Issue: 4 Pages: 303-316

    • DOI

      10.1002/2211-5463.12038

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K12346, KAKENHI-PROJECT-15K19754, KAKENHI-PROJECT-14J05809, KAKENHI-PROJECT-24614007
  • [Journal Article] L-Serine deficiency elicits intracellular accumulation of cytotoxic deoxy-sphingolipids and lipid body formation.2015

    • Author(s)
      Esaki K, Sayano T, Sonoda C, Akagi T, Suzuki T, Ogawa T, Okamoto M, Yoshikawa T, Hirabayashi Y, and Furuya S.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 23 Pages: 14595-14609

    • DOI

      10.1074/jbc.m114.603860

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19754, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-14J05809, KAKENHI-PROJECT-24614007, KAKENHI-ORGANIZER-24116001
  • [Journal Article] Cyclodextrin Complexed [60]Fullerene Derivatives with High Levels of Photodynamic Activity by Long Wavelength Excitation.2013

    • Author(s)
      Ikeda A, Iizuka T, Maekubo N, Aono R, Kikuchi J, Akiyama M, Konishi T, Ogawa T, Ishida-Kitagawa N, Tatebe H, Shiozaki K
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 4 Issue: 8 Pages: 752-756

    • DOI

      10.1021/ml4001535

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592214, KAKENHI-PROJECT-24614007, KAKENHI-PROJECT-24655128, KAKENHI-PROJECT-25288037, KAKENHI-PROJECT-25440086
  • [Journal Article] Aberrant gene expression and sexually incompatible genomic imprinting in oocytes derived from XY mouse embryonic stem cells in vitro.2013

    • Author(s)
      Nitta M, Imamura M, Inoue Y, Kunitomo Y, Lin ZY, Ogawa T, Yogo K, Ishida-Kitagawa N, Fukunaga N, Okano H, Sato E, Takeya T, Miyoshi J
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e58555-e58555

    • DOI

      10.1371/journal.pone.0058555

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592214, KAKENHI-PROJECT-24614007, KAKENHI-PROJECT-25860222
  • [Journal Article] Siglec-15 regulates the formation of functional osteoclasts in concert with DNAX-activating protein of 12 KDa(DAP12)2012

    • Author(s)
      Ishida-Kitagawa N, 他11名(10番目)
    • Journal Title

      J Biol Chem

      Volume: 287(21) Issue: 21 Pages: 17493-17502

    • DOI

      10.1074/jbc.m111.324194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791382, KAKENHI-PROJECT-23592214, KAKENHI-PROJECT-24614007
  • [Journal Article] Abi-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukemic cell adhesion2012

    • Author(s)
      Maruoka M, 他8名(5番目)
    • Journal Title

      Biochem J

      Volume: 441(3) Issue: 3 Pages: 889-899

    • DOI

      10.1042/bj20110951

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791382, KAKENHI-PROJECT-23592214
  • [Journal Article] Purification and identification of lactoperoxidase(LPO) in milk basic proteins(MBP) as an inhibitor of osteoclastogenesis2011

    • Author(s)
      Morita Y, 他6名(7番目)
    • Journal Title

      J Dairy Sci

      Volume: 94(5) Issue: 5 Pages: 2270-2279

    • DOI

      10.3168/jds.2010-4039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791382, KAKENHI-PROJECT-23592214
  • [Journal Article] The L-Ser analog# 290 promotes bone recovery in OP and RA mice2011

    • Author(s)
      Bahtiar A, 他7名(7番目)
    • Journal Title

      Pharmacol Res

      Volume: 64(3) Issue: 3 Pages: 203-209

    • DOI

      10.1016/j.phrs.2011.05.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791382, KAKENHI-PROJECT-23592214
  • [Journal Article] Acid sphingomyelinase regulates osteoclastogenesis by modulating sphingosine kinases downstream of RANKL signaling2011

    • Author(s)
      Bao X, Ogawa T, 他5名(2番目)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 405(4) Issue: 4 Pages: 533-537

    • DOI

      10.1016/j.bbrc.2011.01.061

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Journal Article] 細胞外L-セリンは破骨細胞前駆細胞のアミノ酸栄養シグナル活性化に必須である2010

    • Author(s)
      小川拓哉, 他7名(1番目)
    • Journal Title

      アミノ酸研究

      Volume: 4(2) Pages: 167-169

    • Data Source
      KAKENHI-PROJECT-22791382
  • [Journal Article] 細胞外L-セリンは破骨細胞前駆細胞のアミノ酸栄養シグナル活性化に必須である2010

    • Author(s)
      小川拓哉
    • Journal Title

      アミノ酸研究

      Volume: 4 Pages: 167-169

    • Data Source
      KAKENHI-PROJECT-22791382
  • [Journal Article] 細胞外L-セリンは破骨細胞分化におけるRANKL-RANKシグナル伝達系活性化に必須である2009

    • Author(s)
      小川拓哉
    • Journal Title

      アミノ酸研究 3

      Pages: 63-65

    • Data Source
      KAKENHI-PROJECT-20791038
  • [Journal Article] 細胞外L-セリンは破骨細胞分化におけるRANKL-RANKシグナル伝達系活性化に必須である2009

    • Author(s)
      小川拓哉(1番目), 他7名
    • Journal Title

      アミノ酸研究 3

      Pages: 63-65

    • Data Source
      KAKENHI-PROJECT-20791038
  • [Journal Article] Identification of a novel L-serine analog that suppresses osteoclastogenesis in vitro and bone turnover in vivo.2009

    • Author(s)
      Bahtiar A, 他5名, Ogawa T(7番目), Takeya T.
    • Journal Title

      J Biol Chem. 284

      Pages: 34157-34166

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Journal Article] Potential involvement of Twist2 and Erk in the regulation of osteoblastogenesis by HB-EGF-EGFR signaling.

    • Author(s)
      Nakamura T, 他4名, Ogawa T(6番目), Takeya T, Ishida-Kitagawa N.
    • Journal Title

      Cell Struct Funct. (in press)

    • NAID

      130004053875

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Presentation] 天然資源に着目した骨代謝を調節する骨疾患治療薬の探索2022

    • Author(s)
      渡辺美咲、矢作忠弘、三宅克典、小谷仁司、小川拓哉、松野倫代、川原信夫、松﨑桂一
    • Organizer
      第24回日本骨粗鬆症学会
    • Data Source
      KAKENHI-PROJECT-22K06670
  • [Presentation] マクロファージの細胞外セリンの取り込みに関わるアミノ酸トランスポーターの同定2015

    • Author(s)
      小川拓哉
    • Organizer
      第5回国際医療福祉大学学会学術大会
    • Place of Presentation
      国際医療福祉大学大田原キャンパス
    • Year and Date
      2015-08-30
    • Data Source
      KAKENHI-PROJECT-24614007
  • [Presentation] 細胞内セリン充足度と脂質代謝関連遺伝子発現の連動2011

    • Author(s)
      月野真理子, 草田航, 佐矢野智子, 濱野桃子, 小川拓哉, 加藤久典, 平林義雄, 古屋茂樹
    • Organizer
      日本アミノ酸学会第5回学術大会
    • Place of Presentation
      名古屋大学シンポシオン(名古屋)(一般演題)(ポスター発表)
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] 破骨細胞における新規DAP12会合膜タンパク質の機能解析2011

    • Author(s)
      北川(石田)教弘, 小川拓哉
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)(一般演題)(ポスター発表)
    • Year and Date
      2011-07-29
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] セリン欠乏による遺伝子発現応答にAtf4は関与するか?2011

    • Author(s)
      佐矢野智子, 和田晃, 濱野桃子, 鵜殿美弥子, 片倉喜範, 小川拓哉, 加藤久典, 古屋茂樹
    • Organizer
      日本アミノ酸学会第5回学術大会
    • Place of Presentation
      名古屋大学シンポシオン(名古屋)(一般演題)(ポスター発表)
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] 破骨細胞分化におけるセリン要求性とセリン供給細胞としての骨芽細胞の検討2011

    • Author(s)
      小川拓哉, 北川(石田)教弘
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)(一般演題)(ポスター発表)
    • Year and Date
      2011-07-30
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] 破骨細胞における新規DAP12会合膜タンパク質Siglec-15の機能解析2011

    • Author(s)
      北川(石田)教弘, 田中國太郎, Bao Xilinqiqige, 木村貴徳, 三浦格, 北岡良基, 小川拓哉
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)(一般演題)(口頭・ポスター発表)
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] 破骨細胞分化におけるセリン要求性とセリン供給細胞としての骨芽細胞の検討2011

    • Author(s)
      小川拓哉
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-07-30
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] 細胞外セリンを介した新たな破骨細胞分化制御機構2011

    • Author(s)
      小川拓哉
    • Organizer
      第65回日本栄養・食料学会大会
    • Place of Presentation
      お茶の水女子大学(東京)
    • Year and Date
      2011-05-14
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] セリン欠乏により惹起される細胞内情報伝達系解析2011

    • Author(s)
      川野裕輝, 佐矢野智子, 有本八潮, 小川拓哉, 平林義雄, 古屋茂樹
    • Organizer
      日本アミノ酸学会第5回学術大会
    • Place of Presentation
      名古屋大学シンポシオン(名古屋)(一般演題)(ポスター発表)
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] 細胞外セリンを介した新たな破骨細胞分化制御機構2011

    • Author(s)
      小川拓哉
    • Organizer
      第65回日本栄養・食料学会大会
    • Place of Presentation
      お茶の水女子大学(東京)(シンポジウム)(口頭発表)
    • Year and Date
      2011-05-14
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] セリン合成酵素Phgdh欠損線維芽細胞に惹起される炎症反応の分子機序2011

    • Author(s)
      濱野桃子, 佐矢野智子, 小川拓哉, 加藤久典, 古屋茂樹
    • Organizer
      日本アミノ酸学会第5回学術大会
    • Place of Presentation
      名古屋大学シンポシオン(名古屋)(一般演題)(ポスター発表)
    • Year and Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] 細胞外L-セリンはアミノ酸栄養シグナルを介して破骨細胞分化を制御する2010

    • Author(s)
      小川拓哉
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-07-22
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] 細胞外L-セリンはアミノ酸栄養シグナルを介して破骨細胞分化を制御する2010

    • Author(s)
      小川拓哉
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京都新宿区
    • Year and Date
      2010-07-22
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] Extracellular L-Serine Regulates Intracellular Amino Acid Levels and mTORC1 Activation in Mouse Osteoclast Precursors.2010

    • Author(s)
      Takuya Ogawa
    • Organizer
      32nd Annual Meeting of The American Society for Bone and Mineral Research
    • Place of Presentation
      Toronto, Ontario, Canada
    • Year and Date
      2010-10-17
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] 細胞外L-セリンは破骨細胞前駆細胞のアミノ酸栄養シグナル活性化に必須である2010

    • Author(s)
      小川拓哉
    • Organizer
      日本アミノ酸学会第4回学術大会
    • Place of Presentation
      栃木県日光市
    • Year and Date
      2010-09-17
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] 細胞外L-セリンは破骨細胞前駆細胞のアミノ酸栄養シグナル活性化に必須である2010

    • Author(s)
      小川拓哉
    • Organizer
      日本アミノ酸学会第4回学術大会
    • Place of Presentation
      ホテルサンシャイン鬼怒川(日光)
    • Year and Date
      2010-09-17
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] Extracellular L-Serine Regulates Intracellular Amino Acid Levels and mTORC1 Activation in Mouse Osteoclast Precursors2010

    • Author(s)
      Ogawa T
    • Organizer
      32nd Annual Meeting of The American Society for Bone and Mineral Research
    • Place of Presentation
      Metro Toronto Convention Centre(Toronto)
    • Year and Date
      2010-10-17
    • Data Source
      KAKENHI-PROJECT-22791382
  • [Presentation] Identification of a Novel Inhibitor for Osteoclastogenesis in Vitro and Bone Turnover in Vivo.2009

    • Author(s)
      Anton Bahtiar(代:小川拓哉)
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Presentation] 細胞外L-セリンは破骨細胞分化におけるRANKL-RANKシグナル伝達系活性化に必須である2009

    • Author(s)
      小川拓哉
    • Organizer
      日本アミノ酸学会第3回学術大会
    • Place of Presentation
      京都府立大学
    • Year and Date
      2009-09-30
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Presentation] 細胞外L-セリンは破骨細胞分化におけるRANL-RANKシグナル伝達系活性化に必須である2009

    • Author(s)
      小川拓哉
    • Organizer
      第3回日本アミノ酸学会学術大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Presentation] Identification of a novel inhibitor for osteoclastogenesis in vitro and bone turnover in vivo2009

    • Author(s)
      Bahtiar A(代:小川拓哉)
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Presentation] Lactoperoxidase, a Major Component of Milk Basic Protein, Attenuates in Vitro Osteoclast Differentiation2009

    • Author(s)
      小川拓哉
    • Organizer
      the 31th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Denver, CO, U.S.A.
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Presentation] Lactoperoxidase, a Major Component of Milk Basic Protein, attenuates in vitro Osteoclast Differentitaion.2009

    • Author(s)
      Ogawa T
    • Organizer
      31st Annual Meeting of The American Society for Bone and Mineral Research
    • Place of Presentation
      Colorado Convention Center
    • Year and Date
      2009-09-13
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Presentation] L-セリンによるRANKL-RANKシグナル伝達系活性化機構の解析2008

    • Author(s)
      Ogawa T
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Presentation] A novel role of L-serine for the activation of receptor activator of nuclear factor kappa B ligand (RANKL)-RANK signaling machinery in osteoclastogenesis in Vitro2008

    • Author(s)
      Ogawa T
    • Organizer
      30th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Palais des congres de Montreal
    • Year and Date
      2008-09-13
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Presentation] A Novel Role of L-Serine for the Activation of Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL)-RANK Signaling Machinery in Osteoclastogenesis in yitro2008

    • Author(s)
      小川拓哉
    • Organizer
      30^<th> Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Montr・ al, Qu・ bec, Canada
    • Data Source
      KAKENHI-PROJECT-20791038
  • [Presentation] L-セリンによるRANKL-RANKシグナル伝達系活性化機構の解析2008

    • Author(s)
      小川 拓哉
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-20791038
  • 1.  Norihiro Kitagawa (30294284)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  矢作 忠弘 (40632766)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  石田 教弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 4.  古屋 茂樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  濱野 桃子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  江崎 加代子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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