Hirose Akira 廣瀬享

… Alternative Names

HIROSE Akira 廣瀬享

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Researcher Number	30457395
Other IDs
Affiliation (Current)	2025: 高知大学, 教育研究部医療学系臨床医学部門, 講師
Affiliation (based on the past Project Information) *help	2019 – 2023: 高知大学, 教育研究部医療学系臨床医学部門, 講師 2015 – 2016: 高知大学, 教育研究部医療学系臨床医学部門, 助教 2014: 高知大学, 教育研究部医療学系, 助教 2011: 高知大学, 教育研究部・医療学系, 助教 2010: 高知大学, 教育研究部医療学系, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator NASH / 肝臓学 / 肝線維化 / RAGE / NAFLD / レニンーアンギオテンシン系 / 終末糖化産物(AGE) / レニン-アンギオテンシン系 / ＮＡＳＨ / アンギオテンシン

Elucidation of the mechanism of increased expression of RAGE in the development of NASH and development of liver fibrosis markersPrincipal Investigator
- Principal Investigator
  
  Hirose Akira
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kochi University
The mechanisms for the progression of hepatic fibrosis through AGE-RAGE system and renin-angiotensin systemPrincipal Investigator
- Principal Investigator
  
  HIROSE Akira
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University
Involvement of renin-angiotensin system for the development of NASHPrincipal Investigator
- Principal Investigator
  
  HIROSE Akira
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University

All 2016 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] 非アルコール性脂肪性肝疾患における血清尿酸値2010
- Author(s)
  小笠原光成, 廣瀬享, 他
- Data Source
  KAKENHI-PROJECT-22790650
[Journal Article] NASHの疾患概念．2014
- Author(s)
  西原利治，廣瀬享，小笠原光成
- Journal Title
  
  最新医;學
  
  Volume: 69 Pages: 1791-1794
- Data Source
  KAKENHI-PROJECT-26461011
[Journal Article] NASHの疾患概念2014
- Author(s)
  西原利治，廣瀬享，小笠原光成
- Journal Title
  
  最新医學
  
  Volume: 69 Pages: 1791-1794
- Data Source
  KAKENHI-PROJECT-26461011
[Journal Article] Bofutsushosan, a Japanese herbal (Kampo) medicine, attenuates progression of nonalcoholic steatohepatitis in mice2013
- Author(s)
  Masafumi Ono, Mitsunari Ogasawara, Akira Hirose, Sachiko Mogami, Nobuhiro Ootake, Kosuke Aritake, Takuma Higuchi, Nobuto Okamoto, Shuji Sakamoto, Masahiro Yamamoto, Yoshihiro Urade, Toshiji Saibara, Jude A. Oben.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 49(6) Issue: 6 Pages: 1065-1173
- DOI
  10.1007/s00535-013-0852-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J10660, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460371, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011
[Journal Article] Usefulness of Technetium-99m-2-methoxy-isobutyl-isonitrile liver scintigraphy for evaluating disease activity of non-alcoholic fatty liver disease2012
- Author(s)
  Masuda K, Ono M, Fukumoto M, Hirose A, Munekage K, Ochi T, Okamoto N, Akagi N, Ogawa Y, Saibara T
- Journal Title
  
  Hepatol Res
  
  Volume: 42 Issue: 3 Pages: 273-279
- DOI
  10.1111/j.1872-034x.2011.00923.x
- NAID
  10031144236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790650, KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981
[Journal Article] A novel and comprehensive mouse model of human non-alcoh olic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet2011
- Author(s)
  Ogasawara M, Hirose A, Ono M,
- Journal Title
  
  Liver Int
  
  Volume: 31 Pages: 542-551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790650
[Journal Article] Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis2011
- Author(s)
  Ono M, Ochi T, Munekage K, Ogasawara M, Saibara T
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Issue: 12 Pages: 1223-1229
- DOI
  10.1111/j.1872-034x.2011.00883.x
- NAID
  10031144201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590849, KAKENHI-PROJECT-22790650, KAKENHI-PROJECT-23590979
[Journal Article] Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease2010
- Author(s)
  Asanuma T, Ono M, Kubota K, Hirose A, Hayashi Y, Saibara T
- Journal Title
  
  Gut
  
  Volume: 59 Issue: 2 Pages: 258-266
- DOI
  10.1136/gut.2009.176651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590849, KAKENHI-PROJECT-22790650
[Journal Article] A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet2010
- Author(s)
  Ogasawara M, Ogasawara M, Hirose A, Ono M, Aritake K, Nozaki Y, Takahashi M, Okamoto N, Sakamoto S, Iwasaki S, Asanuma T, Taniguchi T, Urade Y, Onishi S, Saibara T, Oben JA
- Journal Title
  
  Liver Int
  
  Volume: 31 Issue: 4 Pages: 542-551
- DOI
  10.1111/j.1478-3231.2010.02443.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380081, KAKENHI-PROJECT-21590849, KAKENHI-PROJECT-22790650, KAKENHI-PROJECT-23590979
[Presentation] PNPLA3 IS INVOLVED IN HEPATIC LIPIDS METABOLISM THROUGH XBP1 AND MODUALATION OF ENDOPLASMIC RETICULUM SYRESS IN MICE．2016
- Author(s)
  Ono M，Ochi T，Munegage K，Ogasawara M，Hirose A，Nozaki-Fujimura Y，Okamoto N， Iwasaki S，Oben J，Saibara T
- Organizer
  EASL（51th Annual Meeting of The European Association For The Study of The Liver）
- Place of Presentation
  Spain, Barcelona
- Year and Date
  2016-04-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461011
[Presentation] INVOLVEMENT OF AGE-RAGE SYSTEM FOR THE DEVEL-OPMENT OF HEPATIC FIBROSIS IN NASH．2016
- Author(s)
  Munegage K，Ono M，Ochi T，Ogasawara M，Hirose A，Fujimura Y ，Iwasaki S，Saibara T
- Organizer
  uegweek2016（24th United European Gastroenterology Week）
- Place of Presentation
  Vienna, Austria
- Year and Date
  2016-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461011
[Presentation] NAFLD患者における肝脂肪化に対する肝脂肪酸β酸化能の影響-男女の比較解析結果より-．2014
- Author(s)
  小野正文，増田弘誠，宗景玄祐，越智経浩，廣瀬享，西原利治，福本光孝，西岡明人，小川恭弘
- Organizer
  第10回消化器病における性差医学・医療研究会．
- Place of Presentation
  TKPガーデンシティ品川（東京）
- Year and Date
  2014-07-26
- Data Source
  KAKENHI-PROJECT-26461011
[Presentation] 治療による合併症等に難渋した重症自己免疫性肝炎の1例．2014
- Author(s)
  石川洋一，羽柴基，坪井麻記子，藤村靖子，小笠原光成，廣瀬享，高橋昌也，小野正文，岩﨑信二，西原利治
- Organizer
  第110回日本内科学会四国地方会．
- Place of Presentation
  あわぎんホール（徳島）
- Year and Date
  2014-06-08
- Data Source
  KAKENHI-PROJECT-26461011
[Presentation] 治療による合併症等に難渋した重症自己免疫性肝炎の1例2014
- Author(s)
  石川洋一，羽柴基，坪井麻記子，藤村靖子，小笠原光成，廣瀬享，高橋昌也，小野正文，岩﨑信二，西原利治
- Organizer
  第110回日本内科学会四国地方会
- Place of Presentation
  あわぎんホール（徳島）
- Year and Date
  2014-06-08
- Data Source
  KAKENHI-PROJECT-26461011
[Presentation] NAFLD患者における肝脂肪化に対する肝脂肪酸β酸化能の影響-男女の比較解析結果より-2014
- Author(s)
  小野正文，増田弘誠，宗景玄祐，越智経浩，廣瀬享，西原利治，福本光孝，西岡明人，小川恭弘
- Organizer
  第10回消化器病における性差医学・医療研究会
- Place of Presentation
  TKPガーデンシティ品川（東京）
- Year and Date
  2014-07-26
- Data Source
  KAKENHI-PROJECT-26461011
[Presentation] 糖原病Ⅰ型に合併した肝細胞癌の1例．
- Author(s)
  北川達也，石川洋一，宗景匡哉，小笠原光成，廣瀬享，小野正文，岩﨑信二，小林道也，花﨑和弘，西原利治
- Organizer
  第101回日本消化器病学会四国支部例会．
- Place of Presentation
  松山市総合コミュニティセンター（愛媛）
- Year and Date
  2014-06-14 – 2014-06-25
- Data Source
  KAKENHI-PROJECT-26461011
[Presentation] 糖原病Ⅰ型に合併した肝細胞癌の1例
- Author(s)
  北川達也，石川洋一，宗景匡哉，小笠原光成，廣瀬享，小野正文，岩﨑信二，小林道也，花﨑和弘，西原利治
- Organizer
  第101回日本消化器病学会四国支部例会
- Place of Presentation
  松山市総合コミュニティセンター（愛媛）
- Year and Date
  2014-09-12 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26461011
[Presentation] 門脈圧亢進症に対するダナパロイドナトリウムの有用性についての検討
- Author(s)
  廣瀬享，越智経浩，岩﨑信二
- Organizer
  第21回日本門脈圧亢進症学会総会
- Place of Presentation
  京王プラザホテル(東京）
- Year and Date
  2014-09-12 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26461011
[Presentation] IgG4関連疾病に合併した門脈血栓症の一例．
- Author(s)
  江渕みのり，羽柴基，小笠原光成，廣瀬享，藤村靖子，麻植啓輔，小野正文，耕﨑拓大，岩﨑信二，西原利治，伊達慶一，岡林雄大，尾崎和秀
- Organizer
  第102回日本消化器病学会四国支部例会．
- Place of Presentation
  かがわ国際会議場（高松）
- Year and Date
  2014-11-02 – 2014-11-03
- Data Source
  KAKENHI-PROJECT-26461011
[Presentation] gG4関連疾病に合併した門脈血栓症の一例
- Author(s)
  江渕みのり，羽柴基，小笠原光成，廣瀬享，藤村靖子，麻植啓輔，小野正文，耕﨑拓大，岩﨑信二，西原利治，伊達慶一，岡林雄大，尾崎和秀
- Organizer
  第102回日本消化器病学会四国支部例会
- Place of Presentation
  かがわ国際会議場（高松）
- Year and Date
  2014-11-02 – 2014-11-03
- Data Source
  KAKENHI-PROJECT-26461011

1. 小野正文 (70304681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. 西原利治 (60145125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
3. 越智経浩 (30617840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. MUNEKAGE Kensuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 裏出良博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 裏出令子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirose Akira 廣瀬 享

HIROSE Akira 廣瀬 享

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of increased expression of RAGE in the development of NASH and development of liver fibrosis markersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanisms for the progression of hepatic fibrosis through AGE-RAGE system and renin-angiotensin systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of renin-angiotensin system for the development of NASHPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 非アルコール性脂肪性肝疾患における血清尿酸値2010

Author(s)

Data Source

[Journal Article] NASHの疾患概念．2014

Author(s)

Journal Title

Data Source

[Journal Article] NASHの疾患概念2014

Author(s)

Journal Title

Data Source

[Journal Article] Bofutsushosan, a Japanese herbal (Kampo) medicine, attenuates progression of nonalcoholic steatohepatitis in mice2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Usefulness of Technetium-99m-2-methoxy-isobutyl-isonitrile liver scintigraphy for evaluating disease activity of non-alcoholic fatty liver disease2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A novel and comprehensive mouse model of human non-alcoh olic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet2011

Author(s)

Journal Title

Data Source

[Journal Article] Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet2010

Author(s)

Journal Title

DOI

Data Source

[Presentation] PNPLA3 IS INVOLVED IN HEPATIC LIPIDS METABOLISM THROUGH XBP1 AND MODUALATION OF ENDOPLASMIC RETICULUM SYRESS IN MICE．2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] INVOLVEMENT OF AGE-RAGE SYSTEM FOR THE DEVEL-OPMENT OF HEPATIC FIBROSIS IN NASH．2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] NAFLD患者における肝脂肪化に対する肝脂肪酸β酸化能の影響-男女の比較解析結果より-．2014

Author(s)

Organizer

Hirose Akira 廣瀬享

HIROSE Akira 廣瀬享