Hayashi Akihiro 林明宏

… Alternative Names

林明宏ハヤシアキヒロ

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Researcher Number	30459573
Other IDs
Affiliation (Current)	2025: 旭川医科大学, 医学部, 客員助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 旭川医科大学, 医学部, 客員助教 2021: 旭川医科大学, 医学部, 助教 2020: 旭川医科大学, 医学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator ゲノム診断 / デジタルPCR / 低侵襲診断 / 膵癌 / 膵胆道癌 / 胆道癌 / 遺伝子変異 / 膵腫瘍 / リキッドバイオプシー / digital 細胞診 / digital PCR / ドライバー遺伝子

On-site cancer diagnosis by high-sensitivity detection of genomic abnormalities in residual tumor samplesPrincipal Investigator
- Principal Investigator
  
  Hayashi Akihiro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Novel method for capturing a minimal amount of pancreatic tumor-derived mutations using digital PCRPrincipal Investigator
- Principal Investigator
  
  Hayashi Akihiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Multiplex Digital PCR Assay to Detect Multiple KRAS and GNAS Mutations Associated with Pancreatic Carcinogenesis from Minimal Specimen Amounts2023
- Author(s)
  Maeda Chiho、Ono Yusuke、Hayashi Akihiro、Takahashi Kenji、Taniue Kenzui、Kakisaka Rika、Mori Miyuki、Ishii Takahiro、Sato Hiroki、Okada Tetsuhiro、Kawabata Hidemasa、Goto Takuma、Tamamura Nobue、Omori Yuko、Takahashi Kuniyuki、Katanuma Akio、Karasaki Hidenori、Liss Andrew Scott、Mizukami Yusuke
- Journal Title
  
  The Journal of Molecular Diagnostics
  
  Volume: 23 Issue: 6 Pages: 1525-1578
- DOI
  10.1016/j.jmoldx.2023.02.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07954, KAKENHI-PROJECT-21KK0283, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-20K07671, KAKENHI-PROJECT-19K17480, KAKENHI-PROJECT-21K20855, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-23K06759, KAKENHI-PROJECT-22K16010, KAKENHI-PROJECT-21H02758
[Journal Article] Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway2022
- Author(s)
  Kawabata Hidemasa、Ono Yusuke、Tamamura Nobue、Oyama Kyohei、Ueda Jun、Sato Hiroki、Takahashi Kenji、Taniue Kenzui、Okada Tetsuhiro、Fujibayashi Syugo、Hayashi Akihiro、ほか
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 57 Issue: 3 Pages: 208-220
- DOI
  10.1007/s00535-021-01846-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16947, KAKENHI-PUBLICLY-20H04896, KAKENHI-PROJECT-19K07261, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-21K07954, KAKENHI-PROJECT-20K17009, KAKENHI-PROJECT-21KK0283, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-19H03448, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-20K07671, KAKENHI-PROJECT-20K09070, KAKENHI-PROJECT-19K17480, KAKENHI-PROJECT-19K06452, KAKENHI-PROJECT-21H02758
[Journal Article] Prognostic significance of skeletal muscle decrease in unresectable pancreatic cancer: Survival analysis using the Weibull exponential distribution model2021
- Author(s)
  Sato Hiroki、Goto Takuma、Hayashi Akihiro、Kawabata Hidemasa、Okada Tetsuhiro、Takauji Shuhei、Sasajima Junpei、Enomoto Katsuro、Fujiya Mikihiro、Oyama Kyohei、Ono Yusuke、Sugitani Ayumu、Mizukami Yusuke、Okumura Toshikatsu
- Journal Title
  
  Pancreatology
  
  Volume: 21 Issue: 5 Pages: 892-902
- DOI
  10.1016/j.pan.2021.03.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16947, KAKENHI-PROJECT-20K07671, KAKENHI-PROJECT-19K17480, KAKENHI-PROJECT-20H03655
[Journal Article] Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR2020
- Author(s)
  Ono Y, Hayashi A, Maeda C, Suzuki M, Wada R, Sato H, Kawabata H, Okada T, Goto T, Karasaki H, Mizukami Y, Okumura T
- Journal Title
  
  Scientific Reports
  
  Volume: 10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16947
[Presentation] 十二指腸液由来遊離核酸を用いた膵癌リキッドバイオプシーの有用性．2022
- Author(s)
  高橋賢治、林　明宏、水上裕輔．
- Organizer
  第108回日本消化器病学会総会　ワークショップ16：胆膵疾患の遺伝子解析による病態解明・臨床展開
- Data Source
  KAKENHI-PROJECT-20K16947
[Presentation] Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway.2022
- Author(s)
  Hidemasa Kawabata, Yusuke Ono, Hiroki Sato, Kenji Takahashi, Tetsuhiro Okada, Syugo Fujibayashi, Akihiro Hayashi, Takuma Goto, Mikihiro Fujiya, Yusuke Mizukami, Toshiktsu Okumura.
- Organizer
  第26回国際膵臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16010
[Presentation] Tumor-suppressive effect of mutant GNAS through the restriction of tumor aggressiveness in established pancreatic cancer.2022
- Author(s)
  Hidemasa Kawabata, Yusuke Ono, Nobue Tamamura, Hiroki Sato, Kenji Takahashi, Kenzui Taniue, Tetsuhiro Okada, Syugo Fujibayashi, Akihiro Hayashi, Takuma Goto, Hiroaki Konishi, Mikihiro Fujiya, Hidenori Karasaki, Andrew S. Liss, Yusuke Mizukami, Toshikatsu Okumura.
- Organizer
  DDW2022/AGA2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16010
[Presentation] The application of EV RNA panel as liquid biopsy for pancreatic ductal adenocarcinoma.2022
- Author(s)
  Kenji Takahashi, Hiroki Sato, Shugo Fujibayashi, Akihiro Hayashi, Hidemasa Kawabata, Hidetaka Iwamoto, Takuma Goto, Yohei Kitano, Yusuke Mizukami, Toshikatsu Okumura
- Organizer
  第26回国際膵臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16010
[Presentation] Molecular barcode sequencing using duodenal fluid for profiling genomic alterations in pancreatic neoplasms.2022
- Author(s)
  Yusuke Ono, Kenji Takahashi, Akihiro Hayashi, Toru Kawamoto, Tetsuhiro Okada, Keisuke Kimura, Nobuyuki Yanagawa, Hirotoshi Iwano, Kuniyuki Takahashi, Hidenori Karasaki, Yusuke Mizukami．
- Organizer
  第26回国際膵臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16010
[Presentation] 細胞外小胞によるmiR-425の細胞間伝達は上皮間葉形質転換を促進し膵癌進展を制御する2022
- Author(s)
  小山一也、高橋賢治、藤林周吾、林　明宏、河端秀賢、岩本英孝、後藤拓磨、北野陽平、藤谷幹浩、水上裕輔、奥村利勝.
- Organizer
  第30回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-22K16010
[Presentation] 切除不能膵癌化学療法例において骨格筋量低下は予後不良因子である．2021
- Author(s)
  佐藤裕基、岡田哲弘、河端秀賢、林明宏、藤林周吾1、後藤拓磨、小野裕介、杉谷　歩、水上裕輔、藤谷幹浩、奥村利勝．
- Organizer
  第107回日本消化器病学会総会　口演：膵3
- Data Source
  KAKENHI-PROJECT-20K16947
[Presentation] FNB微量検体を用いたデジタルPCRによる膵癌の新規診断技術の開発：Water-burst 遺伝子解析法2021
- Author(s)
  林　明宏、水上裕輔、佐藤裕基、岡田哲弘、河端秀賢、後藤拓磨、唐崎秀則、奥村利勝
- Organizer
  第51回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-20K16947
[Presentation] EUS-FNA検体と血清を用いた膵癌診断における長鎖ノンコーディングRNAの有用性．2021
- Author(s)
  高橋賢治、小山一也、川尻はるな、佐藤裕基、藤林周吾、林　明宏、河端秀賢、岩本英孝、後藤拓磨、山北圭介、北野陽平、水上裕輔、奥村利勝．
- Organizer
  第52回日本膵臓学会大会ワークショップ5：リキッドバイオプシー、内視鏡下採取検体による分子プロファイリング
- Data Source
  KAKENHI-PROJECT-20K16947
[Presentation] 膵多発SPN（solid-pseudopapillary neoplasm）の1例．2021
- Author(s)
  林　明宏、佐藤裕基、藤林周吾、河端秀賢、岩本英孝、高橋賢治、後藤拓磨、山北圭介、北野陽平、水上裕輔、奥村利勝．
- Organizer
  第52回日本膵臓学会大会一般演題（ポスター）P10-3
- Data Source
  KAKENHI-PROJECT-20K16947

1. 水上裕輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 谷上賢瑞

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 小野裕介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 高橋賢治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Akihiro 林 明宏

林 明宏 ハヤシ アキヒロ

Research Projects

Research Products

Co-Researchers

On-site cancer diagnosis by high-sensitivity detection of genomic abnormalities in residual tumor samplesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel method for capturing a minimal amount of pancreatic tumor-derived mutations using digital PCRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Multiplex Digital PCR Assay to Detect Multiple KRAS and GNAS Mutations Associated with Pancreatic Carcinogenesis from Minimal Specimen Amounts2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic significance of skeletal muscle decrease in unresectable pancreatic cancer: Survival analysis using the Weibull exponential distribution model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR2020

Author(s)

Journal Title

Data Source

[Presentation] 十二指腸液由来遊離核酸を用いた膵癌リキッドバイオプシーの有用性．2022

Author(s)

Organizer

Data Source

[Presentation] Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway.2022

Author(s)

Organizer

Data Source

[Presentation] Tumor-suppressive effect of mutant GNAS through the restriction of tumor aggressiveness in established pancreatic cancer.2022

Author(s)

Organizer

Data Source

[Presentation] The application of EV RNA panel as liquid biopsy for pancreatic ductal adenocarcinoma.2022

Author(s)

Organizer

Data Source

[Presentation] Molecular barcode sequencing using duodenal fluid for profiling genomic alterations in pancreatic neoplasms.2022

Author(s)

Organizer

Data Source

[Presentation] 細胞外小胞によるmiR-425の細胞間伝達は上皮間葉形質転換を促進し膵癌進展を制御する2022

Author(s)

Organizer

Data Source

[Presentation] 切除不能膵癌化学療法例において骨格筋量低下は予後不良因子である．2021

Author(s)

Organizer

Data Source

[Presentation] FNB微量検体を用いたデジタルPCRによる膵癌の新規診断技術の開発：Water-burst 遺伝子解析法2021

Author(s)

Organizer

Data Source

[Presentation] EUS-FNA検体と血清を用いた膵癌診断における長鎖ノンコーディングRNAの有用性．2021

Author(s)

Organizer

Data Source

[Presentation] 膵多発SPN（solid-pseudopapillary neoplasm）の1例．2021

Author(s)

Organizer

Data Source

Hayashi Akihiro 林明宏

林明宏ハヤシアキヒロ